1 Left ventricular regional wall curvedness and wall stress ... - CiteSeerX

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Jan 2, 2009 -
Articles in PresS. Am J Physiol Heart Circ Physiol (January 2, 2009). doi:10.1152/ajpheart.00525.2008

Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy Liang ZHONG1, Yi SU2, Si-Yong YEO2, Ru-San TAN1, Dhanjoo N GHISTA3, Ghassan KASSAB4,5,6 1

Deparment of Cardiology, National Heart Centre, Mistri Wing, 17 Third Hospital Avenue,

Singapore; 2Institute of High Performance Computing, Agency for Science, Technology and Research, Singapore; 3Parkway Health, Singapore; 4Biomedical Engineering; 5Surgery, and 6

Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

Mail correspondence to: Ghassan S. Kassab, Ph.D. Department of Biomedical Engineering Indiana University Purdue University Indianapolis Indianapolis, IN 46202 Email: [email protected]

1 Copyright © 2009 by the American Physiological Society.

ABSTRACT Geometric remodeling of the left ventricle (LV) following myocardial infarction is associated with changes in myocardial wall stress. The objective of this study was to determine the regional curvatures and wall stress based on 3D reconstructions of the LV using magnetic resonance imaging (MRI). Ten ischemic dilated cardiomyopathy (IDCM) and ten normal subjects underwent MRI scan. The former also underwent delayed gadolinium-enhancement imaging to delineate the extent of myocardial infarct. Regional curvedness (C), local radii of curvature and wall thickness were calculated. The % curvedness change (∆C) between enddiastole and end-systole was also calculated. In normal heart, a short-axis and long-axis 2D analysis showed a 41% ± 11% and 45% ± 12% increase of the mean of peak systolic wall stress between basal and apical sections, respectively. There was no significant difference, however, in peak systolic wall stress from basal and apical sections (ANOVA, P=0.298) using the 3D analysis. The LV shape in patients with IDCM differed from normal subjects in several ways. First, the LV had more spherical shape (sphericity index, 0.62 ± 0.08 vs. 0.52 ± 0.06, p