1038 Correspondence In-vitro activity of cefditoren ...

1038

Correspondence

In-vitro activity of cefditoren against clinical isolates of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae, Haemophilus influenza* and Neisseria meningitidis J Amimicrob Chemother 1996; 37: 1037-1039

Table. In-vitro activity of cefditoren and other antibiotics against clinical isolates of 5. pneumoniae, influenzae and N meningitidis S. pneumoniae MIG»/MBG» (mg/L) Penicillin-sensitive benzylpenicillin ampicillin cefditoren cefotaxime ceftnaxone meropenem vancomycin

(no.) (47) 0.015/0.03 0.03/0.03 0.015/0.015 O.O15/O.O3 0.015/0.015 0.015/0.015 0.5/0.5

Penicillin-intermediate* benzylpenicillin ampicillin cefditoren cefotaxime ceftnaxone meropenem vancomycin

(no.) (13) 1/2 2/2 0.5/1 I/I 0.5/1 0.5/0.5 0.5/0 5

Penicillin-resistant' benzylpenicillin ampicillin cefditoren cefotaxime ceftnaxone meropenem vancomycin

(no.) (12) 2/4 4/8 11 2/2 1/1 1/2 0 5/0.5

H. influenzae

MIC«/MBG» (mg/L) (27) 1/2 1/1

0.008/0.015 0.015/0.015 £0.004/0.008 0.06/0.06

N. meningitidis MIG»/MBC« (mg/L) (35) 0.06/0.06 0.06/0 12 £0.004/0.008 £0.004/£0.004 £0.004/£0.004 0.008/0.015

— (7) 2/4 2/2

£0.OO4/£0.OO4 £ 0.004/£0.004 £ 0.004/£0.004 0 015/0.015

H.

(35) 0.25/0.25 0.5/1 0.008/0 008 O.O15/O.OI5 £0.004/£0.004 0.06/0.06

—

(8) 8/>8 8/>8 £0.004/£0.004 £0.004/0.008 £0.004/£0.004 0.015/0.03 —

"Penicillin-sensitive: MICs = S. pneumoniae: