A Distributed, Collaborative Intelligent Agent System ...

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Detroit, Michigan 48201 USA (email: [email protected]). R. Michael Massanari ..... suspected drug-ADR signal pairs based on pre-marketing clinical trials, and ... In our case, the Management Agent works as a server that provides services ..... that (1) the dedicated ADRMonitor agent of a real physician possessed a ...
This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication.

TITB-00030-2008.R2

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A Distributed, Collaborative Intelligent Agent System Approach for Proactive Postmarketing Drug Safety Surveillance Yanqing Ji, Hao Ying, Senior Member, IEEE, Margo S. Farber, John Yen, Fellow, IEEE, Peter Dews, Richard E. Miller, R. Michael Massanari

Abstract—Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is of great importance. The current approach to postmarketing surveillance primarily relies on spontaneous reporting. It is a passive surveillance system and limited by gross underreporting (