A micromethod for the in vitro micronucleus assay - Semantic Scholar

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Methyl methanesulfonate. MMS. 66-27-3. Al. 99%. FM0. 1-Methyl-3-nitro-nitrosoguanidine. MNNG. 70-25-7. F. 97%. DMSO. 4-Nitroquinoline N-oxide. 4-NQO.
Mutagenesis vol.14 no.4 pp.403–410, 1999

A micromethod for the in vitro micronucleus assay

Fabrice Nesslany1 and Daniel Marzin1,2,3 1Laboratoire de Toxicologie Ge ´ ne´tique, Institut Pasteur de Lille, 59019 Lille Cedex and 2De´partement Toxicologie–Hydrologie–Hygie`ne, Universite´ de

Lille II, Droit et Sante´, Faculte´ des Sciences Pharmaceutiques et Biologiques, 59006 Lille Cedex, France

A micromethod for the in vitro micronucleus assay was developed using L5178Y cells to enable the rapid screening of a large number of molecules. The method is quick, simple to perform and needs very small amounts of compound, i.e.