Nov 5, 2013 - Walter J. Paulus3, Pedro Brugada1. 1 Heart Rhythm Management ...... Okin PM, Devereux RB, Nieminen MS, Jern S, Oikarinen L et al. (2001).
A Novel Electrocardiographic Index for the Diagnosis of Diastolic Dysfunction Mehdi Namdar1,2,4*☯, Patric Biaggi2☯, Barbara Stähli2, Bernhard Bütler2, Rubén Casado-Arroyo1, Danilo Ricciardi1, Moisés Rodríguez-Mañero1, Jan Steffel2, David Hürlimann2, Christian Schmied2, Carlo de Asmundis1, Gian-Battista Chierchia1, Andrea Sarkozy1, Thomas F. Lüscher2, Rolf Jenni2, Firat Duru2, Walter J. Paulus3, Pedro Brugada1 1 Heart Rhythm Management Centre, Cardiovascular Division, UZ Brussel — VUB, Brussels, Belgium, 2 Cardiovascular Centre, Cardiology, University Hospital of Zurich, Zurich, Switzerland, 3 Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands, 4 Service de Cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland
Abstract Background: Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD. Methods and Results: ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422±24ms and 434±32ms vs. 409±25ms, p
