Medical Sciences · Vol. 55 · 2010 · DOI: ... ... ... · Advances©inMedical University of Bialystok, Poland
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N-acetyl-β-D-hexosaminidase in Gestational Diabetes Mellitus - a preliminary study
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Dudzik D1,3*, Skotnicki M2, Zarzycki W3, Wiśniewska RJ1, Górska M3, Zwierz K4 1 Department of Pharmacology, Medical University of Bialystok, Poland 2 Clinical Department of Perinatology, Medical University of Bialystok, Poland 3 Clinical Department of Endocrinology, Diabetology and Internal Diseases, Medical University of Bialystok, Poland 4 Medical Institute, College of Computer Science and Business Administration in Lomza, Poland
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* CORRESPONDING AUTHOR: Department of Pharmacology, Medical University of Bialystok, 2A Mickiewicza Str., 15-089 Bialystok, Poland. telephone: +48 85 7485570; Fax: +48 85 7485575; e-mail:
[email protected] (Danuta Dudzik)
Received 27.10.2010 Accepted 26.11.2010 Advances in Medical Sciences Vol. 55 · 2010 DOI: ... ... ... © Medical University of Bialystok, Poland
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ABSTRACT Purpose: N-acetyl-β-D-hexosaminidase (HEX) is an exoglycosidase which has been extensively studied and which has been used as a marker for inflammation. It was therefore thought that measurement of the activity of this enzyme might be useful in diagnosing gestational diabetes mellitus (GDM) as this condition is frequently associated with inflammation. The main object of the study was the determination of N-acetyl-β-D-hexosaminidase activity in women with GDM and 3 months postpartum in comparison with control groups of non-pregnant and healthy pregnant women. Material and Methods: Twenty-five blood serum samples from women with GDM and women 3 months postpartum; 20 blood serum samples from non-pregnant and healthy pregnant women (control groups) were enrolled into the study. Serum was prepared from all blood samples and HEX activity was measured by the method of Chateriee et al. (modified by Zwierz et al). Results: A statistically significantly increase in the activity of HEX in the GDM blood serum was found as compared to the control groups (p
