ABCD - PLOS

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specific lysis. BHRF1-specific CD8+ T cell clones. D. EBNA2-specific CD8+ T cell clones. 0. 0.5. 1. QPR. IFNγ (ng/ml). 0. 1. TSS. MVA EBNA2. MVA EBNA3B.
B IFNg (ng/ml)

Peptide pool # HLA-A 1 2 25 68 1 2 1 3 2 24 2 11 2 24 1

-B 39 40 15 39 8 39 7 40 27 35 40 51 44 55 8 57

14.1 14.2 14.3 14.4 14.5

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

IFNg (ng/ml)

Donor 8 0.4 0.3 0.2 0.1 0

BHRF1 Donor 9 0.8 0.6 0.4 0.2 0 1 2 3 4 5 6 Peptide pool #

Peptide #

-C 0304 12 0303 12 7 0304 7 2 4 0304 15 0303 16 6 8

HLA-A 68

-B 44

Peptide #

-C 7

3 68 35 44 4 5 1 2 44 55 3 5 12 2 8 44 3 11

2 11 15 40 3 7 0 1 2 3 IFNg (ng/ml)

0 0.5 1 1.5 2 2.5 IFNg (ng/ml)

Peptide sequence 14.2 KPGGPWRPEPNTSSPSMPEL 14.3 WRPEPNTSSPSMPELSPVLG 14.4 NTSSPSMPELSPVLGLHQGQ TSSPSMPEL No peptide

C

3.1 3.2 3.3 3.4 3.5 3.6

EBNA2

A

EBNA2-specific CD8+ T cell clones

IFNg (ng/ml)

Peptide sequence

IFNg (ng/ml)

0.45

3.1 NSETFTETWNRFITH ETFTETWNR No peptide

0.57 0.6 0.0

0.6 0.09

D

BHRF1-specific CD8+ T cell clones vBHRF1

MVA EBNA2 MVA EBNA3B

TSS 0

0 0.5 1 IFNg (ng/ml)

vTK-

QPR

1

ETF

SRV

0 10 20 30 40 0 10 20 % specific lysis

30