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Nov 18, 2015 - luminal diagnostiqués au service d'anatomie pathologique et suivi au service ...... mandibule, pancréas, os) s'étaient toujours révélées malignes. ...... manual after loading with caesium source, 35 GY to point A, in one session, ...

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International Conference on Cancer in Africa

A BST R A C T PUBLICATION AORTIC 2015 10th International Conference on Cancer in Africa Marrakech, Morocco 18 - 22 NOVEMBER 2015 In collaboration with the Lalla Salma Foundation for Cancer Prevention & Treatment

ROADMAP TO CANCER CONTROL IN AFRICA LA FEUILLE DE ROUTE VERS LE CONTROLE DU CANCER EN AFRIQUE

POSTER MP001 Moroccan Poster Room Friday–Sunday 20–22 November 2015

Abbass, Fouad LES TUMEURS LUMINALES DU CANCER DU SEIN ET LEUR PRONOSTIC: EXPERIENCE DU CHU HASSAN II DE FES APROPS DE 265 CAS Abbass, Fouad*1; Akasbi, Yousra2; Bennis, Sanae1; Nejjari, Chakib3; El Mesbahi, Omar2; Amarti Riffi, Afaf1 1 Laboratoire d’Anatomie Pathologique, CHU Hassan II, Fès, Morocco; 2 Service d’Oncologie Médicale, CHU Hassan II, Fès, Morocco; 3Laboratoire d’Épidémiologie, Recherche Clinique et Santé Communautaire, Fès, Morocco

Correspondance Abbass, Fouad Email: [email protected]

Objectif La classification du cancer du sein s’est affinée grâce à l’émergence des analyses génomiques, protéomiques et de leur application en clinique. En se basant sur l’expression des récepteurs hormonaux (aux œstrogènes (RE) et à la progestérone) (RP) on peut distinguer différents groupes moléculaires: luminal A, luminal B, basal-like et Her2+. Les tumeurs du groupe luminal A et B expriment les récepteurs hormonaux, mais présentent des caractéristiques clinico-pathologiques différentes. L’objectif de cette étude est de déterminer les caractéristiques clinque, histologique et moléculaire de 256 tumeurs de cancer du sein de type luminal puis d’évaluer leur pronostic en déterminant la survie globale et la survie sans récidives. Méthode Etude rétrospective étalée sur 3 ans, comportant 265 cas de cancer du sein de type luminal diagnostiqués au service d’anatomie pathologique et suivi au service d’oncologie médicale du CHU Hassan II de Fès. Les tumeurs sont analysées histologiquement et classées après étude immunohistochimique en deux groupes: luminal A (RE positif et/ou RP positif, Her2 négatif) et luminal B (RE positif et/ou RP positif, Her2 positif). La survie globale et la survie sans progression est déterminée par la méthode de Kaplan-Meier. Résultats 77% des tumeurs sont du groupe luminal A et 23% luminal B. 44% des patientes de type luminal B sont âgées de moins de 40 ans contre 33% des patientes de type luminal A. La taille tumorale moyenne dans le groupe luminal B (4 cm) est aussi importante que dans le groupe luminal A (3,5 cm). Par contre, 29% des tumeurs luminales B sont de grade histologique III de SBR versus 23% pour les tumeurs luminales A. Les patientes de type luminal B renferme des taux importants d’atteinte ganglionnaire, de métastase à distance et d’emboles vasculaire (74%; 31% et 40% respectivement) que celles de type luminal A (63%; 23% et 37% respectivement).

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 20151

POSTER MP002

Abbass, Fouad

Moroccan Poster Room Friday–Sunday 20–22 November 2015

Abbass, Fouad*1; Akasbi, Yousra2; Bennis, Sanae3; Nejjari, Chakib4; El Mesbahi, Omar2; Amarti Riffi, Afaf1 1 Laboratoire d’Anatomie Pathologique, CHU Hassan II, Fès, Maroc, Morocco; 2 Service d’Oncologie Médicale, CHU Hassan II, Fès, Maroc, Morocco; 3 Faculté de Médecine et de Pharmacie de Fès, Maroc, Morocco; 4Laboratoire d’Épidémiologie, Recherche Clinique et Santé Communautaire, Fès, Morocco

PHENOTYPE MOLECULAIRE ET PRONOSTIC DES CANCERS DU SEIN DIAGNOSTIQUES AU CHU HASSAN II, FES MAROC

Correspondance Abbass, Fouad Email: [email protected]ahoo.fr

Objectif L’analyse des profils d’expression des tumeurs a permis d’améliorer la classification du cancer du sein et d’identifier au moins cinq groupes des tumeurs d’évolution hétérogène. Le but de cette étude est de classer 366 tumeurs de cancer du sein invasif en cinq grands groupes selon leurs profils protéiques par immunohistochimie, de déterminer leur caractéristiques cliniques, pathologiques et pronostiques. Méthode Il s’agit d’une étude rétrospective de 366 patientes atteintes d’un cancer du sein invasif, diagnostiqués au sein du laboratoire d’anatomie pathologique CHU Hassan II. Nous avons classé par immunohistochimie les tumeurs en cinq groupes: luminal A (ER+ et/ou PR+, HER2-,CK8/18+), luminal B (ER+ et/ou PR+, HER2+,CK8/18+), Her2+ (ER-, PR-, HER2+), basal-like (ER-, PR-, HER2-, CK 5/6+ et/ou CK14+ et /ou EGFR1+) et non classés (ER-, PR-, HER2-, CK5/6- et EGFR1- et CK14-). 181 patientes ont été suivies au service d’oncologie médicale. La survie globale (SG) et la survie sans progression (SSP) à 3 ans est estimée par la méthode de Kaplan-Meier. Résultats 53,6% des tumeurs sont du groupe luminal A, 16,4% luminal B, 12,6% Her2+, 12,6% basal-like et 4,9% non-classées. Le groupe luminal A renferme le plus faible taux de grade III (23%), d’embols vasculaires (36%) et de métastases à distance (23%); alors que le groupe des non-classées et basal-like représentent un taux élevé de grade III (53%, 48% et 42% respectivement), une faible proportion d’embols vasculaires (22% et 28% respectivement) et d’envahissement ganglionnaire (55% et 61,5% respectivement). L’envahissement ganglionnaire est plus élevé dans les deux groupes luminal B et Her2+ (74% et 67% respectivement). 31% des patientes luminal B et 26% du groupe Her2+ ont développé des métastases à distance. Le taux de SSP à 3 ans diffère significativement (p=0.002) entre le groupe luminal A (59%) et les autres groupes: luminal B (41%), Her2+ (38%) et triples négatives (basal-like et non-classé).

2AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

WORKSHOP Free Communication of Abstracts 2 11:00–13:00 Friday 20 November 2015

Abdallah, Fatmah CHALLENGES IN THE PHARMACOLOGICAL MANAGEMENT OF CHILDREN WITH NONHODGKINS LYMPHOMA IN KENYATTA NATIONAL HOSPITAL Abdallah, Fatmah*; Mwangi, Winnie; Karimi, Peter; Githinji, Charles University of Nairobi, Kenya

Correspondence Abdallah, Fatmah Email: [email protected]

Background Non Hodgkin’s lymphoma is the commonest childhood cancer in equatorial Africa and Kenya. It is a chemo sensitive tumor with a five year event free survival of greater than 90% in the west and a one year survival rate of 40–50% in developing countries. There have been no documented studies done in Kenya on the various challenges faced by patients/guardians that may hinder its optimal management. Objective To investigate the challenges faced in the management of Non Hodgkin’s lymphoma in children during maintenance. Methodology: A hospital based cross-sectional study, on 19 children with Non Hodgkin’s Lymphoma in the maintenance phase of therapy at Kenyatta National Hospital. Data was collected using structured questionnaires and from patient files and was analysed using SPSS version 17.0 and Fischer’s exact test. Results Most of the patients, 13(68.4%) were male, with a male:female ratio of 2:1. The mean age was 9.84 yrs (95% CI: 8.3, 11.3). 42.1% of the patients had missed their oral medication. The method of acquisition of oral medication, estimated expenditure on medication per month and whether the guardian was counseled on the side effects of the medication, were found to be statistically significant (p value 0.037, 0.02 and 0.037 respectively) reasons for this lack of adherence to oral medication. The most prevalent side effects of chemotherapy, were, hairloss (94.7%) and change in nail/skin pigmentation (73.7%). Most patients (63%) had cumulative doses of doxorubicin below 400mg/m2, while 10% were above this. Conclusion Overall adherence to oral chemotherapy was 57.9%. Method of acquisition of the medication, estimated expenditure on medication per month and counseling on medication and its side effects were significant barriers to optimal management. Recommendation Oral chemotherapy should be made available and at a subsidized rate at Kenyatta National Hospital. Clinicians and pharmacists must counsel the parents on effects of chemotherapy.

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 20153

WORKSHOP Bladder Cancer 14:30–15:45 Saturday 21 November 2015

Abdelhalim, Inas CONCURRENT CHEMO-RADIATION FOR MUSCLE INVASIVE BLADDER CANCER Abdelhalim, Inas Mansoura University Hospitals, Egypt

Correspondence Abdelhalim, Inas Email: [email protected]

Background Bladder cancer is the 3rd most common malignancy in men & the 4th in women in Egypt. Radical cystectomy is the standard treatment for muscle invasion. CCRT is based on micrometastases are associated with muscle invasion & increased frequencies of metastases. The aim of the study is to evaluate the efficacy of CCRT for patients with muscle invasion bladder cancer. The primary end point was RR & the secondary end points were toxicities, PFS & OS. Patients and methods 100 patients with pathologically diagnosed muscle invasive bladder cancer, clinical stage T2–3 N0 M0 were enrolled in the study. The initial therapy consisted of transurethral resection of the tumor followed by 3 cycles of weekly paclitaxel 90 mg/m2 D1, D8, D15 & carboplatin AUC 5 D1 then RT with concurrent cisplatin 20 mg/m2 weekly. RT consisted of 2 phases, a fractionated dose of 45Gy/4 1/2 weeks (180cGy daily in 5 consecutive days to the whole pelvis) followed by phase II in which 20Gy/ 2 weeks was given to the bladder. Results All patients were evaluable for response & toxicities, median age was 52 years (42-65 years) males to females ratio was 3:1, ORR was 90% (CR 80%, PR 10%), 3 patients were having progressive disease, 2 patients died due to other causes & 5 patients refused to do cystoscope & biopsy. Toxicities were G2 anemia & neutropenia (10%) during chemotherapy, (20%) experienced late GI toxicity G2 in the form of diarrhea & tenesmus & (20%) developed G2 urinary toxicity in the form of reduced bladder capacity with less voiding intervals < 2 hours. There were no grade 3&4 toxicities & no treatment related deaths. The 2 years DFS was 77.7% and the 2 years and the 5 years OS were 95% and 83%. Conclusion CCRT after transurethral resection are therapeutic option that result in high rate of longterm survival retaining the bladder function. Even if radical cystectomy remains the standard of care for muscle invasive bladder cancer, CCRT can be an option to carefully selected patients.

4AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

POSTER P151 General Poster Display Saturday & Sunday 21 & 22 November 2015

Abdelkrim, Messafeur INCIDENCE DES CANCERS DANS LA WILAYA DE SIDI BEL ABBES EN 2012–2013: DONNÉES DU REGISTRE DES CANCERS DE SIDI BELABBÉS, ALGÉRIE Abdelkrim, Messafeur*; Abdelnacer, Tou; Abdelkrim, Soulimane Registre du Cancer, Algeria

Correspondance Abdelkrim, Messafeur Email: [email protected]

Introduction Ce registre de population du cancer couvre la wilaya de sidi bel abbés qui compte jusqu’à 650 000 habitants Objectif L’objectif principal est de fournir des données sur le cancer dans la wilaya de sidi bel abbés. Ceci permettant de dresser le profil épidémiologique des cancers de la wilaya Matériel et méthode Le recueil actif de tous les cas incidents de 2012 et 2013 de la wilaya de sidi bel abbés à partir des dossiers médicaux des malades hospitalisés au CHU de Sidi Bel Abbés, les laboratoires d’anatomopathologie hospitalier et privés. Le codage de la localisation et la morphologie des tumeurs se fait par la CIM-O et la CIM-10.La saisie et l’analyse des données se font par le CanReg5. Résultats Le nombre de cas incidents en 2012 et 2013 est de 1484(sauf C44 1492) cas avec prédominance féminine (sex ratio 0.8). Chez la femme les tumeurs du sein occupent la première place avec une incidence (59,2/100000hts) suivie du col (7,6/100000 hts) tandis que chez l’homme, ce sont les cancers broncho-pulmonaires (10,8/100 000 hts) suivi des cancers du colon (10,2/100 000 hts).

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 20155

WORKSHOP Free Communication of Abstracts 5 14:30–15:45 Saturday 21 November 2015

Abdellaoui Maane, Imane A NEW APPROACH FOR PROSTATE CANCER MOLECULAR DIAGNOSTIC (PRELIMINARY STUDY) Abdellaoui Maane, Imane*1; Sefrioui, Hasssan1; Al Bouzidi, Abderrahmane2; Bakri, Youssef3; Dakka, Nadia3; Moumen, Abdeladim1 1 Mascir Moroccan Foundation for Advanced Sciences Innovation and Research, Morocco; 2Hôpital Militaire d’Instruction Mohammed V (HMIMV), Morocco; 3 Faculté des Sciences de Rabat, Université Mohamed V, Morocco; 3Faculté des Sciences de Rabat, Université Mohamed V, Morocco

Correspondence Abdellaoui Maane, Imane Email: [email protected]

Prostate cancer (PCa) diagnosis has two major problems: evolutivity and over diagnosis, therefore identifying new and more specific biomarkers that allow discriminate between PCa and benign disease is an urgent requirement. The objective of this work is to develop a non-invasive diagnostic method that could replace or at least complete the serum PSA (prostate specific antigen) test to better indicate a prostate biopsy. Method and method The analysis of the differential expression of two Prostate specific genes PCA3 (Prostate Cancer Antigen 3) and AMACR (-methylacyl-coaracemase) was performed by RT-qPCR (Reverse Real time transcription quantitative polymerase chain reaction), on 104 paraffin embedded biopsies. The relative quantification is based on the normalization by a reference gene that has been selected by GeNorm and Normfinder software. A statistical test using XLSTAT macros was used to establish both the threshold of the target gene expression and the relevance of the quantification method were established by a statistical test using XLSTAT macros. Results The selected reference gene was successfully amplified in all samples. XLSTAT analysis showed: For PCA3 an AUC value (Area Under Curve) of 0.735, a sensitivity ‘SE’ and specificity ‘SP’, of 72% and 71% respectively. For AMACR an AUC value of 0.871, a SE and SP of 84% and 86% respectively. The combination of AMACR with PCA3 leads to a better test performances, since the SE and SP increase to 93%, 75% respectively. Conclusion The results of this preliminary study are very promising. The parameters studied showed the relevance and accuracy of our test, however, it remains to confirm these results using urine samples for a new non-invasive diagnostic approach.

6AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

POSTER MP003 Moroccan Poster Room Friday–Sunday 20–22 November 2015

Abdoul Salam, Diarra CERVICAL CANCER KNOWLEDGE, RISK FACTORS AND SCREENING AMONG ADULT MOROCCAN WOMEN IN A PRIMARY HEALTH CARE SETTING Abdoul Salam, Diarra*1; El Fakir, Samira1; Abousselham, Loubna2; Belakhel, Latifa3; Bekkali, Rachid4; Nejjari, Chakib1 1 Dept of Epidemiology and Public Health, Fac. of Med., Univ. Sidi Mohammed Ben Abdellah, Fez, Morocco; 2Direction of Population, Rabat, Morocco; 3 Directory of Epidemiology & Fight against Diseases (DELM), Ministry of Health, Rabat; 4Fondation Lalla Salma Prevention & Treatment of Cancers, Rabat

Correspondence Abdoul Salam, Diarra | [email protected] Objective To describe the risk factors of cervical cancer and to investigate the factors associated with the acceptability of cervical cancer screening in Morocco. Method It was a cross sectional study, which started in July 2011 based on consultants and eligible women for early detection programs in a primary care health center (primary level) in five prefectures of Morocco. Our target population was represented by all the consultants and consenting women from30 to 50 years old. Results A total 1444 women were included in the study. The mean age was 40.6± 10.2 years (range, 30–50 years). Only 3.1% of women reported a personal history of cancer; family history of cancer was present in 26.2% of the study population. Acceptability of cervical examination was 86. 7%. 92.7% of the women had their first sexual intercourse at 16 or above. Increased accepting rates were found among married women (OR 0.42) and among women living in urban area (ORs of 0.16). The screening acceptance is associated with using of condom, using of hormonal contraceptive and nulliparous women. Conclusion This results of survey on eligible women in cervical cancer early detection program for regions where program are being started was not still satisfactory, to show a positive attitude vis-à-vis screening. It highlighted the factors determining behaviors of women for early screening cervical.

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 20157

POSTER P152 General Poster Display Saturday & Sunday 21 & 22 November 2015

Abdulkarim, Nura RADIATION-FREE TREATMENTS FOR CERVICAL CANCER: LOW RESOURCE SETTING PERSPECTIVE Abdulkarim, Nura*; Lawal, Ishak; Abdulfatah, Lukman Federal Medical Centre Katsina, Nigeria

Correspondence Abdulkarim, Nura Email: [email protected]

Objective Radiation therapy with teletherapy and brachytherapy remains an important component of treatment for most stages of cervical cancer. However, in most developing countries radiation treatment protocols and equipment are difficult to access due to large patient turnout, electric power failure, and little number of qualified personnel, thus, a large number of patients die from the disease without having access to treatment at all, even the palliative radiation therapy. We search for effective, acceptable and affordable treatment protocols for various stages of cervical cancer within the available limited resources that are comparable to worldwide standard treatments. Method We adopted the available facilities and treatment options in the management of various stages of cervical cancer in other to overcome some of the peculiar challenges mitigating against timely intervention in management of clinically diagnosed cervical cancer. We also conducted a literature search Results Eight patients with different stages of cervical cancer were managed, 3 patients with stage 1b1 disease had simple total abdominal hysterectomy plus adjuvant chemotherapy, 2 with stage 1b2 disease had modified radical hysterectomy plus adjuvant chemotherapy and 3 with locally advanced disease had primary chemotherapy alone. Preliminary evaluation shows that this protocol of radiation free management of cervical cancer is acceptable alternative to radiation therapy that is not accessible. Conclusion Cervical cancer patients, who live in developing countries with limited resources, would require newer radiation-free therapeutic options. The feasibility and therapeutic values of these potential forms of management need to be prospectively evaluated.

8AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

WORKSHOP Free Communication of Abstracts 8 11:00–12:00 Sunday 22 November 2015

Abid, Larbi LE PLAN CANCER ALGÉRIE 2015–2019 PR. LARBI ABID SERVICE DE CHIRURGIE VISCÉRALE & ONCOLOGIQUE HÔPITAL BOLOGHINE, ALGER, ALGÉRIE Abid, Larbi Hôpital Bologhine, Alger, Algeria

Correspondence Abid, Larbi Email: [email protected]

Le plan cancer Algérie 2015–2019 Pr. Larbi ABID En Algérie, on comptabilise 45.000 nouveaux cas de cancers chaque année avec 24.000 décès, chiffres qui s’expliquent par le caractère particulièrement accéléré de la transition démographique. Ce fléau représente une charge particulièrement lourde par les souffrances et drames qu’il entraine ainsi que par la charge financière particulièrement élevée et en constante augmentation risquant de déséquilibrer toute l’architecture financière de notre système de santé. Aussi un plan cancer pour les années 2015-2019 ayant pour principal objectif la réduction de la mortalité et la morbidité des patients par cancer et l’amélioration de la démarche préventive contre les facteurs de risque et de la qualité de vie pendant et après le traitement, vient d’etre mis en place dans notre pays. Ce plan se décline en 8 axes stratégiques (prévention contre les facteurs de risque; amélioration du dépistage de certains cancers; amélioration du diagnostic; redynamisation du traitement; organisation de l’orientation, l’accompagnement et le suivi des patients; développement du système d’information et de communication sur les cancers; renforcement de la formation et de la recherche sur les cancers; renforcement des capacités de financement de la prise en charge des cancers), 19 objectifs, 60 actions et 239 mesures. La mise en œuvre de ces objectifs ne pourra être abordée qu’après la mise en place de procédures élaborées de manière précise. Ces procédures définissent les taches successives à réaliser. La majorité des actions exigent des efforts pour une organisation innovante, une coordination plus importante et une exploitation plus pertinente et valorisante du capital humain. La mise en œuvre des différentes mesures a été estimée et des évaluations régulières seront réalisées afin de prendre les décisions appropriées: évaluer l’efficacité, corriger ou abandonner des mesures qui n’auraient pas atteint leur objectif.

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 20159

PLENARY Cervix Plenary 09:10–10:30 Saturday 21 November 2015

Abousselham, Loubna IMPLANTATION DU PROGRAMME ORGANISE DE DETECTION PRECOCE DES CANCERS DU SEIN ET DU COL DE L’UTERUS AU MAROC Abousselham, Loubna Ministère de La Santé, Morocco

Correspondance Abousselham, Loubna Email: [email protected]

Introduction Les cancers du sein et du col de l’utérus représentent respectivement 34.3% et 13.3% des cancers de la femme. L’incidence et la mortalité élevées ont justifié la mise en place d’un programme organisé de détection précoce de ces deux cancers. Objectif Améliorer la prise en charge des cas de cancers du sein et du col utérin en mettant en place un programme organisé de détection précoce de ces 2 cancers. Matériel et méthode L’implantation du programme de détection précoce des cancers du sein et du col utérin été basée sur l’analyse des données épidémiologiques et de l’offre de soins existante. Ceci a permis de définir les aspects programmatiques adaptés aux spécificités du pays: populations cibles, tests de dépistage et d’adapter le circuit d’orientation et du recours et de fixer les axes d’intervention du programme. Résultats Un grand investissement en matière de construction et d’équipements des structures. 2596 prestataires de soins sont formés en technique de détection précoce. Une campagne médiatique de sensibilisation sur le dépistage du cancer du sein est organisée annuellement par la Fondation Lalla Salma – Prévention et Traitement des Cancers (FLSC). Ainsi, 1843770 femmes âgées de 45 à 69 ans ont bénéficiées de la détection précoce du cancer du sein en 2013–2014, soit un taux de participation de 53.3%. 1544 cancers du sein diagnostiqués. Pour la détection précoce du cancer du col utérin, 107679 femmes ont bénéficiées du dépistage par IVA en 2014, 456 lésions précancéreuses du col dépistées, 107 cancers invasifs diagnostiqués. Conclusion L’analyse des réalisations de l’expérience marocaine dans l’implantation du programme révèle: • Rôle partenariat stratégique entre le Ministère de la Santé et FLSC; • Importance de la mise en place de stratégie de dépistage adaptée et adaptable aux spécificités du système de soins du pays; • Expérience marocaine transposable au niveau des pays en voie de développement.

10AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

WORKSHOP Free Communication of Abstracts 3 14:30–15:45 Friday 20 November 2015

Abuidris, Dafalla INCIDENCE AND SURVIVAL RATES OF OVARIAN CANCER IN SUDAN Abuidris, Dafalla*1; Sidahamed Ibnoof, Rehab2; Elsanousi, Mohamed3; Eltayeb, Elgaylani1; Elhaj, Ahmed1; Mohamed, Sulma4 1 National Cancer Institute, Sudan; 2Minstery of Health, Sudan; 3University of Gezira, Sudan; 4Purdue University, United States

Correspondence Abuidris, Dafalla Email: [email protected]

Background Ovarian cancer is the second most common gynecological cancer worldwide. Little is known about the disease in Sudan. The objectives of the study are to evaluate the incidence rate, age and stage at diagnosis, and median survival time of patients seen at the National Cancer Institute – University of Gezira. Method Data was collected in a prospective study of women with ovarian cancer during a period of eleven (2000–2011) years of follow-up. Descriptive statistics were used to summarize the distribution of the demographics of the sample. The sirect method was used to compute age-standardized rate (ASR) using 1966 and 2000 World Standard Populations (WSPs). The Kaplan-Meier method was used to estimate survival functions and median survival time. Log-rank tests were used to statistically compare between the survival functions. Results There were steady increases in ovarian cancer incidence rates during 2000–2009, with slight decline in 2010 and 2011. Patients’ age range was 9–90. The age-specific incidence rate increased greatly in women aged 55 years or older. The majority had stage III or IV disease. The annual ASR using WSPs 1966 and 2000 as standard populations were 3.3 and 3.7 per 100,000 women, respectively. The median survival time was 31 months (95% confidence interval 19–43). The 5-year cumulative survival rate was 38%. Conclusion In Sudan, ovarian cancer affects postmenopausal women akin to what is reported in the developed world with low incidence rate. Women present with advanced stage disease that result in short survival time.

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 201511

WORKSHOP Gynaecologic Oncologic Pathology (2) 11:00–13:00 Wednesday 18 November 2015

Adams, Tracey Sheridan GENETICS OF OVARIAN CANCER, AN OVERVIEW Adams, Tracey Sheridan Groote Schuur Hospital/University of Cape Town, South Africa

Correspondence Adams, Tracey Email: [email protected]

Ovarian cancer is not the commonest gynaecological malignancy in Africa but it has the highest case fatality ratio. More than 80% of women present with advanced stage 3 and 4 disease with a 5 year survival of 30%. There is currently no evidence for screening for ovarian cancer as there is no known precancerous lesion. Transvaginal ultrasound and tumour markers such as CA125 only assist with detecting established cancer. Once the diagnosis of ovarian cancer is suspected, the standard of care is cyto-reductive surgery. In the majority of cases, adjuvant platinum-based chemotherapy is required after surgery. There have been many advances in chemotherapy over the last decade, but unfortunately, this has not translated into improved survival. Approximately 90% of ovarian cancers are epithelial tumours. In the past, all ovarian cancer would be treated in the same manner. We now know that ovarian cancer is a heterogeneous disease, each with its own distinct origin, genetic alteration and clinic pathological features. We are moving towards understanding the genetic origin of disease and hence towards a more personalised approach. This could impact on tumour behaviour, chemo-sensitivity and overall prognosis. Approximately 10% of women with ovarian cancer are known to have a hereditary component. Identifying high risk women and their offspring could assist in prevention by offering risk-reducing surgery.

12AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

POSTER P002 General Poster Display Thursday & Friday 19 & 20 November 2015

Adamu, Stella-Maris CERVICAL CANCER PREVENTION: REVIEW OF A MEDICAL MISSION APPROACH TO ‘SCREEN & TREAT’ WOMEN IN CAMEROON Adamu, Stella-Maris Michael and Mauritia Patcha Foundation, United States

Correspondence Adamu, Stella-Maris Email: [email protected]

Objective Cervical cancer is the second most prevalent female cancer in Cameroon, with a mortality rate of 80%. There is no country wide cervical cancer screening program. Cancer awareness is marginal and diagnosis often occurs in advanced stage of the disease. The Michael and Mauritia Patcha Foundation (MMPF) is a non-profit organization based in Maryland, USA that advocates for increased access to cancer prevention, diagnosis and treatment resources in Cameroon, Africa. The objective of this review is to evaluate the impact of the cervical cancer screening program carried out during its medical missions. Method MMPF has organized two medical mission trips to Cameroon since 2013 during which it partners with Cameroon Baptist Convention Health Service (CBCHS) to perform cervical screening using the Visual Inspection with Acetic Acid (VIA) method. Using the ‘screen and treat’ guidelines women between the ages of 26 and 65 were screened. For these women this is the only opportunity to receive cancer screening. Precancerous lesions are immediately treated with cryotherapy. Those needing loop electrosurgical excision procedure (LEEP) or biopsy in the event of more advanced disease are referred back to CBCHS clinics. All participants receive valuable oral and/or written information about cancer risk factors, prevention and symptoms with emphasis on dispelling myths and stigma. Results In two years 943 women have undergone the VIA screening procedure during the medical missions. 47 or 4.98% were diagnosed with abnormal cervical cells. 33 or 3.49% received treatment with cryotherapy and 14 or 1.48% were referred for LEEP or further diagnosis. Of those referred 4 or 28% had cancer and were referred to an oncology service for treatment. Conclusion The MMPF cervical cancer screening campaign is making a positive impact in preventing cervical cancer, increasing awareness and reducing the cancer burden. There is benefit in continuing the cervical screening program

AORTIC 2015|MARRAKECH|18–22 NOVEMBER 201513

POSTER P003 General Poster Display Thursday & Friday 19 & 20 November 2015

Adejimi, Adebola KNOWLEDGE OF CERVICAL CANCER, HUMAN PAPILLOMAVIRUS INFECTIONS AND THEIR PREVENTIVE METHODS AMONG WOMEN IN OSOGBO, SOUTH-WESTERN NIGERIA Adejimi, Adebola*; Sabageh, Olukemi; Egbewale, Bolaji Ladoke Akintola University of Technology, Nigeria

Correspondence Adejimi, Adebola Email: [email protected]

Objective Cervical cancer is preventable but yet the leading cause of death among women in developing countries. It is important to understand the level of awareness about cervical cancer and the preventive methods in developing the strategies for an effective intervention. The objectives of this study were to assess the awareness and knowledge of cervical cancer, Human papillomavirus (HPV) infections, their preventive methods and the screening practices among women in Osogbo, South-Western Nigeria. Method A cross-sectional study was conducted using a multi-stage sampling technique. A pretested, semi-structured and interviewer administered questionnaire was used in data collection. Chi square statistics was used at level of significance of 5%. Results A total of 443 women were interviewed. The mean age of the respondents was 29.8±7.8 years. About 61.4% were married with 20.2% of them in polygamous marriage. Majority (81.7%) of the respondents were sexually active with 51.1% of them having multiple sexual partners. However, 151 (34.1%) had heard of cervical cancer, 70 (15.8%) had heard of the screening tests for cervical cancer, 39(8.8%) had heard of HPV infections and 28(6.3%) had heard of HPV vaccination. Of the respondents, only 15 (3.4%) of them had good knowledge of cervical cancer, HPV infections and their preventive methods. About 10(2.3%) had done Papaniculaou smear for cervical cancer screening but 341 (77.0%) of the respondents were willing to be screened for cervical cancer if the services are available and affordable. Significantly higher proportion of those who had more than twelve years of education were aware of cervical cancer, HPV infections and their preventive methods. Conclusion There is a very low level of knowledge about cervical cancer, HPV infections and their preventive methods among this sample of women. Effective information, education and communication strategies are required to improve their knowledge about cervical cancer and HPV.

14AORTIC 2015|MARRAKECH|18–22 NOVEMBER 2015

WORKSHOP Cancer risk assessment and genetic counselling (2) 11:00–13:00 Wednesday 18 November 2015

Adejumo, Prisca ESTABLISHING A CANCER RISK AND PREVENTION CLINIC IN NIGERIA: LESSONS FROM THE FIELD Adejumo, Prisca*1; Oluwatosin, Abimbola1; Ogundiran, Temidayo1; Adedokun, Babatund1; Ademola, Oluyinka1; Olopade, Olufunmilayo2 1 University of Ibadan, Nigeria; 2University of Chicago, United States

Correspondence Adejumo, Prisca Email: [email protected]

Introduction The World Health Organization projects that cancer will be the leading cause of death globally by year 2030 unless urgent strategies are implemented to curb the rising epidemic. We sought to establish a cancer risk and prevention clinic and to determine the effects of genetic nursing education on nurses’ competencies in genetic counseling of cancer patients and their relatives in selected teaching hospitals in Nigeria. Method A 2-group quasi-experimental design was utilized using a structured questionnaire adapted from the University of Chicago Cancer Risk Clinic and multistage sampling technique to select 491 nurses, 100 cancer patients and 35 family members. Knowledge, attitude and skills were compared between intervention and control groups using paired t test and independent sample t test. Results We have successfully delivered educational intervention in the three hospitals. The mean age of respondents in the experimental and control groups was 41.5 ± 7.6 and 39.2 ± 9.1years respectively. Overall, less than a quarter (21.3%) of the respondents knew the difference between genetics and genomics. The mean knowledge scores between the two groups were not significantly different at baseline (p=0.510). However, the experimental group had higher mean scores compared to controls at 6 weeks (p