Acute renal failure in SARS patients: more than ...
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Acute renal failure in SARS patients: more than ...
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Acute renal failure in SARS patients: more than rhabdomyolysis Vin-Cent Wu1,2, Po-Ren Hsueh3, Wei-Chou Lin4, Jenq-Wen Huang2, Hung-Bin Tsai1, Yung-Ming Chen2, Kwan-Dun Wu2 and The SARS Research Group of the National Taiwan University College of Medicine and National Taiwan University Hospital 1
Department of Internal Medicine, Far Eastern Memorial Hospital, and Departments of 2Internal Medicine, 3Laboratory and 4Pathology Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
failure;
histopathology;
Severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) has been identified as the causal agent of SARS. Although not common, acute renal failure (ARF) in SARS patients usually has a catastrophic outcome, with a mortality rate of 77% [1]. The causes of ARF in association with SARS are unknown. An increase in creatine kinase (CK) may play a role [2]. We present two patients who met the definition of probable SARS.
Case 1 A 78-year-old man presented with fever and dyspnoea. SARS-CoV was detected using reverse transcription– polymerase chain reaction (RT–PCR) from his nasopharyngeal aspirate (NPA) and a search for serum IgG antibodies to the SARS-CoV was positive. On the 7th day, his IgG antibody titre against SARS-CoV was 1 : 200, and serum creatinine (SCre) was 1.3 mg/dl. On the 10th day, SCre increased to 1.9 mg/dl in spite of stable haemodynamics; serum myoglobin level was 271 ng/ml (normal
