Aditya Mittal - Indian Institute of Technology Delhi

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M. Tech. thesis work in Biochemical Engineering and Biotechnology”. ..... Invited lecture: Dynamics and self-assembly in biological systems: Peeking into the.
Aditya Mittal Kusuma School of Biological Sciences Block IA, Rm 304 Indian Institute of Technology (IIT) Delhi Hauz Khas, New Delhi 110016, India. Tel: +91-11-26591052 Fax: +91-11-25682037 e-mail: [email protected]

Home Address: 30 New Campus, IIT Delhi, Hauz Khas, New Delhi 110016, India. Tel: +91-11-26591530 www: http://web.iitd.ac.in/~amittal

RESEARCH INTERESTS - Kinetics and self-assembly in biological systems EDUCATION 1997 - 2002 1992 - 1996

Ph. D. (Biological Sciences) B. Tech. (Biochemical Engineering)

Drexel University, Philadelphia, PA, USA Harcourt Butler Technological Institute (HBTI), Kanpur, UP, India

EMPLOYMENT 2012 - present 2008 - 2012

2004 - 2008 2002 - 2004 1998 - 2002 1996 - 1997

Professor, School of Biological Sciences, IIT Delhi, India. Associate Professor, School of Biological Sciences (12/2008 – 12/2012), Centre for Biomedical Engineering (08/2008 – 11/2008), Dept. of Biochemical Engineering and Biotechnology (08/2008), IIT Delhi, India. Assistant Professor, Dept. of Biochemical Engineering and Biotechnology, IIT Delhi, India. Visiting Fellow, Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Bethesda, MD, USA. Teaching/Research Assistant, Dept. of Biology, Drexel University. Brewer/Management Trainee, Breweries Division, Shaw Wallace and Co. Ltd., Mumbai, Maharashtra, India.

ACADEMIC HONORS 2015 2008 - 2013 2005 - 2009 2001 2000 1997 1997 1993 1992 1989, 1990

Teaching Excellence Award, IIT Delhi. Outstanding Young Faculty Fellow, IIT Delhi. Associate, Indian Academy of Sciences, Bangalore, India. Best Graduate Poster Award, Drexel and MCP Hahnemann Universities. Best Graduate Poster Award, Sigma Xi Scientific Society, Philadelphia. Dean’s Fellow, Drexel University. Nominee, Govt. of India for Commonwealth Scholarships in UK. Academic Merit Scholarship, HBTI Kanpur. Merit Certificate for top score (Mathematics) in the AISSCE at the national level. Merit Certificates in the Indian Mathematics Olympiads.

OTHER HONORS 2014

2011, 2015

Thesis Supervisor of Ms. Suneyna Bansal - recipient of the American Society for Cell Biology (ASCB) International Travel Award (USD 1500), IIT Delhi for presenting her work titled "On the symbiotic origins of eukaryotic plasma membranes" at the 2014 ASCB/IFCB Meeting in Philadelphia, PA, USA, from December 6-10, 2014. Co-Chair with Bengt Norden (Chairman of the Nobel Committee for Chemistry 2001-2004), Session on “Proteins-I: New in Dynamics & Folding” in Albany 2011:

Aditya Mittal

2006 - 2014

2008 2007 2006 2006 2005 2004 2001 1993 - 1994 1986

[email protected] Conversation 17 (June 14-18, 2011), and, Chair for session on “Enzymes: Design and Dynamics” in Albany 2015: Conversation 19 (June 9-13, 2015) at SUNY Albany, USA. Gold medalist: Badminton (2008) & Chess (2009), Silver medalist: Badminton (2007, 2013, 2014), Bronze medalist: Badminton (2006, 2009, 2012) - Inter-IIT staff sports meets. Thesis Supervisor of BOSS Award recipient Mr. Vivek Hasija, IIT Delhi for “Best M. Tech. thesis work in Biochemical Engineering and Biotechnology”. Thesis Supervisor of BOSS Award recipient Miss. Megha Sharma, IIT Delhi. “Asia 21 Young Leader”, Asia Society, NY, USA. “India’s Young Blood” in Cover Feature, Chemical & Engineering News, (American Chemical Society). Invited Participant, Indo-US Frontiers of Science symposium: US National Academy of Sciences & Indo-US Science and Technology Forum. Co-Chair, Sub-Committee (Education) On Postdoctoral Training (SCOPT), American Society for Cell Biology, USA (elected in Dec. 2003 Annual mtg.). Pennsylvania State Collegiate Chess Champion (Team: Drexel University). Cultural Secretary (WCH-II), HBTI Kanpur. Diploma in Indian Classical Music (instrumental: Tabla), Prayag Sangeet Samiti.

EXTRAMURAL POSITIONS AND SERVICES 2010 - present 2016 2016 2015 - 2016 2012 2007 - 2009 2009, 2012, 2013, 2015 2010 - 2015 2008 - 2009 2007 - 2009 2006 - 2008 2004 - present

Editorial Board, Journal of Biomolecular Structure and Dynamics (Taylor and Francis, UK). Member, Faculty selection committee, Dept. of Technology, Savitribai Phule Pune University. Chairman, Selection Committee for Commonwealth Fellowships UK – Biotechnology, Ministry of Human Resource Development (MHRD), Govt. of India. Member, Kendriya Vidyalaya (KV) Management Committee, KV JNU, Delhi. Guest Editor, Journal of Biosciences (Indian Academy of Sciences, India and Springer). Asian Editor, Journal of Biomedical Nanotechnology (American Scientific Publishers, USA). Selection panel Chair (2015)/Member (2009)/Reviewer (2012, 2013), United States – India Educational Foundation (USIEF) for Fulbright-Nehru Doctoral and Professional Research Fellowships. Member, Board of Mentors, Innovative Ideators, Indore. Member, Board of Mentors, Sanghvi Institute of Management and Science, Indore, India. Director (Advisory), Honorary, Appin Knowledge Solutions, New Delhi, India. National review committee member, USIEF for International Fulbright Science and Technology Award for Outstanding Foreign Students. Ad-hoc reviewer: FASEB J., Eur. J. Biophys., J. Am. Chem. Soc., Mol. Membr. Biol., J. Biosci., J. Biomed. Nanotechnol., J. Nanosci. Nanotechnol., Chem. Eng. Sci., Chem. Eng. J., Curr. Sci., Microbiol. Res., J. Biol. Eng., Appl. Phys. Lett., Geomicrobiology J., Sci. Rep., ANR - the French National Research Agency.

POSITIONS AND SERVICES AT IIT DELHI 2017 - 2018 2016 - 2017 2014 - 2016 2013, 2014 2010 - 2012

Chairman JEE (Advanced) - 2018 Vice-Chairman JEE (Advanced) - 2017 Associate Dean, Student Affairs (Events) Chairman, TRYST (annual science & technology student festival). President, Board for Recreational and Creative Activities (BRCA).

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Aditya Mittal

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2009 - 2011 2008, 2009, 2013, 2014

2007 - 2010 2005 - 2008 2005 - 2011

2004 - present

Member, Golden Jubilee Committee. Contingent Leader, IIT Delhi team for the inter-IIT staff sports meets. Vice-President, BRCA. Coordinator, National Cadet Corps (NCC). Coordinator/Organizational member for International and National conferences & workshops (e.g. CHEMCON – 2005, Intl. Conf. on Nanosci. & Tech. – 2006, InCoB – 2006, IASc Annual Meeting – 2008, Laser Spectroscopy and Nanophotonics – 2008, Nucleic Acids in Disease and Disorders – 2011). Member of the team conducting IIT-JEE (up to 2012), GATE, JAM operations.

EXTRAMURAL RESEARCH FUNDING Years Funding Agency 2012-2022 Kusuma Trust UK 2013 Hira Group, Raipur 2011-2014 DST, Govt. of India 2008-2011 DBT - Swiss Agency for Dev. and Coop. 2007-2011 DBT, Govt. of India 2007-2010 DBT, Govt. of India 2006-2009 DST, Govt. of India 2006-2009 CSIR, Govt. of India 2006-2007 M/s. GENOM Biotech. Pvt. Ltd., Nasik, India

Amount (INR)

215397000 450000 4033000 4934000 4088000 3268000 1134000 1300000 1036000

PI/Co-PI PI (2017-2022), Co-PI (2012-2016) Co-PI, Co-PI: T.R.Sreekrishnan Co-PI, PI: Sanat Mohanty Co-PI, PI: Vikram Sahai PI Co-PI, PI: P.K.Roychoudhary PI PI Co-PI, PI: Subhash Chand

PROFESSIONAL AFFILIATION/MEMBERSHIP • American Society for Cell Biology (USA) – Member since 2001 • Biophysical Society (USA) – Member since 2001 • Indian Institute of Chemical Engineers (India) – Life member since 2004 • The Asia Society (USA) – Asia 21 Young Leader 2006 TEACHING 2009 - present (Semester System)

2004 - 2009 (Semester System)

1998 - 2002 (Quarter System)

Instructor, School of Biological Sciences, IIT Delhi: 1. Introductory Biology for Engineers (SBL100) 2. Modern Biology for Engineers (SBL101) 3. Introduction to Practical Modern Biology (SBP200) 4. Biometry (SBL701) 5. Advanced Cell Biology (SBL703; co-taught) 6. Biological Membranes (SBV882) 7. Current Topics in Computational Biology (SBV887) Instructor, Dept. of Biochemical Engineering and Biotechnology, IIT Delhi: 1. Enzyme Engineering and Technology (BEL403; co-taught 2004-2009) 2. Bioprocess Calculations (BEL102; 2006-2009) 3. Bionanotechnology (BEL721; co-taught 2004-2008) 4. Membrane Applications in Bioprocessing (BEL416; co-taught 2004-2007) 5. Current Topics (BEL719; co-taught 2006-2008) 6. Physical and Chemical Properties of Biomolecules (BEL311; 2007-2008) 7. Design of Bioprocesses (BEP303; 2004-2005) 8. Transport Processes – II (CHL204; 2005-2006) TA, Dept. of Biology (formerly Bioscience & Biotechnology), Drexel University: 1. Chemical and Biological Foundations for Engineers (CBFE III) – Honors Sections, Instructor: Prof. Donald McEachron 2. Applied Biology, Instructor: Prof. Donald McEachron 3. Human Physiology (I and II), Instructor: Prof. Donald McEachron 4. Biochemistry (I and II), Instructor: Prof. Joe Bentz 5. Comparative Physiology, Instructor: Prof. Michael O’ Connor

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Aditya Mittal

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PUBLICATIONS Research Articles (reverse chronological, indexed peer-reviewed journals only, 4 cover illustrations since 2007) 1. Mittal, A. and S. Singh. 2017. Insights into eukaryotic evolution from transmembrane domain lengths. J. Biomol. Struct. Dyn. Jul 6:1-7. doi: 10.1080/07391102.2017.1345699. 2. Sharma, A., S. Sharma, A. Mittal and S. N. Naik. 2016. Evidence for the involvement of nematocidal toxins of Purpureocillium lilacinum 6029 cultured on Karanja deoiled cake liquid medium. World J. Microb. Biot. 32:82 (doi: 10.1007/s11274-016-2038-z) 3. Singh, S. and A. Mittal. 2016. Transmembrane domain lengths serve as signatures of organismal complexity and viral transport mechanisms. Sci. Rep. 6: 22352 (doi: 10.1038/srep22352). 4. Bansal, S. and A. Mittal. 2015. A statistical anomaly indicates symbiotic origins of eukaryotic membranes. Mol. Biol. Cell 26: 1238-1248. 5. Mishra, A., P. S. Rana, A. Mittal and B. Jayaram. 2014. D2N: Distance to the native. BBA-Proteins Proteom. 1844: 1798-1807. 6. Sharma, A., S. Sharma, A. Mittal and S. N. Naik. 2014. Statistical optimization of growth media for Paecilomyces lilacinus 6029 using non-edible oilcakes. Ann. Microbiol. 64: 515-520. 7. Mittal, A. and C. Acharya. 2013. Protein folding: Is it simply surface to volume minimization? J. Biomol. Struct. Dyn. 31: 953-955. 8. Bansal, S. and A. Mittal. 2013. Extracting curvature preferences of lipids assembled in flat bilayers shows possible kinetic windows for genesis of bilayer asymmetry and domain formation in biological membranes. J. Membrane Biol. 246: 557-570. 9. Mishra, A., S. Rao, A. Mittal and B. Jayaram. 2013. Capturing native/native like structures with a physico-chemical metric (pcSM) in protein folding. BBA-Proteins Proteom. 1834: 1520-1531. 10. Mittal, A. and C. Acharya. 2012. Extracting signatures of spatial organization for biomolecular nanostructures. J. Nanosci. Nanotechnol. 12: 8249-8257. 11. Kohli, S., Y. Singh, K. Sharma, A. Mittal, N. Z. Ehtesham and S. E. Hasnain. 2012. Comparative genomic and proteomic analyses of PE/PPE multigene family of Mycobacterium tuberculosis H37Rv and H37Ra reveal novel and interesting differences with implications in virulence. Nucleic Acids Res. 40: 7113-7122. 12. Mittal, A. and B. Jayaram. 2012. A possible molecular metric for biological evolvability. J. Biosci. 37: 573-577. 13. Naresh, M., S. Das, P. Mishra and A. Mittal. 2012. The chemical formula of a magnetotactic bacterium. Biotechnol. Bioeng. 109: 1205-1216. 14. Mittal, A. 2012. Self-generated and reproducible dynamics in “gene years” represent life. J. Biomol. Struct. Dyn. 29: 609-611. 15. Naresh, M., M. Sharma and A. Mittal. 2011. Intracellular magneto-spatial organization of magnetic organelles inside intact bacterial cells. J. Biomed. Nanotechnol. 7: 572-577. 16. Mittal, A.* and B. Jayaram*. 2011. The newest view on protein folding: Stoichiometric and spatial unity in structural and functional diversity. J. Biomol. Struct. Dyn. 28: 669-674. (*equal contribution, corresponding authors) 17. Mittal, A.* and B. Jayaram*. 2011. Backbones of folded proteins reveal novel invariant amino acid neighborhoods. J. Biomol. Struct. Dyn. 28: 443-454. (Cover Illustration). (*equal contribution, corresponding authors) 18. Mittal, A.*, B. Jayaram*, S. R. Shenoy and T. S. Bawa. 2010. A stoichiometry driven universal spatial organization of backbones of folded proteins: Are there Chargaff’s rules for protein folding? J. Biomol. Struct. Dyn. 28:133-142. (Cover Illustration). (*equal contribution, corresponding authors) 19. Taneja, N. K., S. Dhingra, A. Mittal, M. Naresh and J. S. Tyagi. 2010. Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C. PLoS One 5(5): e10860 (doi:10.1371/journal.pone.0010860). 20. Naresh, M.*, V. Hasija, M. Sharma and A. Mittal*. 2010. Synthesis of cellular organelles containing nano-magnets stunts growth of magnetotactic bacteria. J. Nanosci. Nanotechnol. 10: 4135-4144. (Cover Illustration). (*equal contribution)

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21. Mittal, A. and R. Grover. 2010. Self-assembly of biological membranes into 200-400 nm aqueous compartments. J. Nanosci. Nanotechnol. 10: 3085-3090. 22. Naresh, M., K. Gopinadhan, S. Sekhar, P. Juneja, M. Sharma and A. Mittal. 2009. NSOM/HRTEM characterization of biologically derived cubo-octahedral nano-magnets. IEEE T. Magn. 45: 48614864. 23. Gupta, R., P. Mishra and A. Mittal. 2009. Enhancing nucleic acid detection sensitivity of Propidium Iodide by a three nanometer interaction inside cells and in solutions. J. Nanosci. Nanotechnol. 9: 2607–2615. 24. Gupta, V., K. Saharan, L. Kumar, R. Gupta, V. Sahai and A. Mittal. 2008. Spectrophotometric ferric ion biosensor from Pseudomonas fluorescens culture. Biotechnol. Bioeng. 100: 284-296. 25. Gupta, V., R. Gupta, R. Grover, R. Khanna, V. Jangra and A. Mittal. 2008. Delivery of molecules to cancer cells using liposomes from bacterial cultures. J. Nanosci. Nanotechnol. 8: 2328–2333. 26. Sharma, M., V. Hasija, M. Naresh and A. Mittal. 2008. Functional control by codon bias in magnetic bacteria. J. Biomed. Nanotechnol. 4: 44-51. Covered as Research Highlight titled "Magnetic charm in the genes" in Nature India (www.nature.com/nindia), doi:10.1038/nindia.2008.138 (10 March 2008). 27. Arora, S., V. Bhat and A. Mittal. 2007. Correlating single cell motility with population growth dynamics for flagellated bacteria. Biotechnol. Bioeng. 97: 1644-1649. 28. Gattegno, T.*, A. Mittal*, C. Valansi, K. C. Q. Nguyen, D. H. Hall, L. V. Chernomordik and B. Podbilewicz. 2007. Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Mol. Biol. Cell (Cover Illustration) 18: 1153-1166. (*equal contribution) 29. Sharma, M., M. Naresh and A. Mittal. 2007. Morphological changes in magnetotactic bacteria in presence of magnetic fields. J. Biomed. Nanotechnol. 3: 75–80. 30. Gupta, R., M. Sharma and A. Mittal. 2006. Effects of membrane tension on nanopropeller driven bacterial motion. J. Nanosci. Nanotechnol. 6: 3854-3862. 31. Zaitseva, E., A. Mittal, D.E. Griffin and L. V. Chernomordik. 2005. Class II fusion protein of alphaviruses drives membrane fusion through the same pathway as class I proteins. J. Cell Biol. 169: 167-177. 32. Tran, T. T., A. Mittal, T. M. Aldinger, J. W. Polli, A. D. Ayrton, H. Ellens, and J.Bentz. 2005. The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKIIhMDR1 cells. Biophys. J. 88: 715-738. 33. Leikina, E., A. Mittal, M. Cho, K. Melikov, M. M. Kozlov and L. V. Chernomordik. 2004. Influenza hemagglutinins outside of the contact zone are necessary for fusion pore expansion. J. Biol. Chem. 279: 26526–26532. 34. Tran, T. T., A. Mittal, T. Gales, B. Maleef, J. Kratz, E. Yang, T. Aldinger, P. Gorycki, J. W. Polli, A. Ayrton, H. Ellens and J. Bentz. 2004. Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier. J. Pharma. Sci. 93: 2108-2123. 35. Mittal, A., E. Leikina, L. V. Chernomordik and J. Bentz. 2003. Kinetically differentiating influenza hemagglutinin fusion and hemifusion machines. Biophys. J. 85: 1713-24. 36. Bentz, J. and A. Mittal. 2003. Architecture of the influenza hemagglutinin membrane fusion site. BBA-Biomembranes 1614: 24-35. 37. Mittal, A., T. Shangguan and J. Bentz. 2002. Measuring pKa of activation and pKi of inactivation for influenza hemagglutinin from the kinetics of membrane fusion. Biophys. J. 83: 2652-2666. 38. Mittal, A., E. Leikina, J. Bentz and L.V. Chernomordik. 2002. Kinetics of influenza hemagglutinin mediated membrane fusion as a function of technique. Anal. Biochem. 303: 145-152. 39. Bradley J. C., S. Babu, B. Carroll and A. Mittal. 2002. A study of spatially coupled bipolar electrochemistry on the sub-micrometer scale: colloidal particles on surfaces and cylinders in nucleartrack etched membranes. J. Electroanal. Chem. 522: 75-85. 40. Mittal, A. and J. Bentz. 2001. Comprehensive kinetic analysis of influenza hemagglutinin-mediated membrane fusion: Role of sialate binding. Biophys. J. 81: 1521-1535. 41. Bradley J. C., S. Babu, A. Mittal, P. Ndungu, B. Carroll, and B. Samuel. 2001. Pulsed bipolar electrodeposition of palladium onto graphite powder. J. Electrochem. Soc. 148: C647-651. 42. Bentz, J. and A. Mittal. 2000. Deployment of membrane fusion protein domains during fusion. Cell Biol. Intl. 24: 819-838.

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Aditya Mittal

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Invited Articles and Book Contributions (reverse chronological) 43. Jayaram, B., A. Mittal, A. Mishra, C. Acharya and G. Khandelwal. 2013. Chapter titled “Universalities in Protein Tertiary Structures: Some New Concepts” in Biomolecular forms and functions, World Scientific Publishing Co. Pte. Ltd., Singapore, Editors: M. Bansal and N. Srinivasan, pp 210-219. 44. Bansal, M., B. Jayaram and A. Mittal. 2012. Editorial titled “Nucleic Acids in Disease and Disorder – Understanding the language of life emerging from the ‘ABC’ of DNA”, J. Biosci., Vol. 37(3): 375378. 45. Mittal, A., M. Naresh and V. Hasija. 2011. Chapter titled “Biological Synthesis of Metallic Nanocrystals and Bio-Imprinting” in the Encyclopedia of Nanoscience & Nanotechnology, Vol. 12: 17-26, Editor: H. S. Nalwa, American Scientific Publishers. 46. Mittal, A., V. Hasija, V. Bhat, S. Arora, M. Sharma and R. Gupta. 2011. Chapter titled “Bacterial Nanopropellers” in the Encyclopedia of Nanoscience & Nanotechnology, Vol. 11: 439-448, Editor: H. S. Nalwa, American Scientific Publishers. 47. Mittal, A. 2009. Commentary titled "Pay commission will 'degrade' IIT faculty", Nature India, doi:10.1038/nindia.2009.278. 48. Mittal, A. 2009. Commentary titled "Michael Jackson and science", Nature India, doi:10.1038/nindia.2009.165. 49. Mittal, A. 2009. Book review for “Protocells: Bridging Nonliving and Living Matter” by Rasmussen et al. (eds). MIT Press, 55, Hayward Street, Cambridge, MA 02142. 2009. 684 pp. Curr. Sci. 96(11): 1530-1532. 50. Mittal, A. 2008. Commentary titled "Women are from Venus, are magnetic bacteria from Mars?" Nature India, doi:10.1038/nindia.2008.216. 51. Mittal, A. 2008. Chapter titled “Enzymes” in the e-book Microbial Physiology and Biochemistry, National Science Digital Library (NDSL), the National Institute of Science Communication and Information Resources (NISCAIR), Council for Scientific and Industrial Research, Govt. of India. 52. Mittal, A. 2008. Chapter titled “Nanotechnology in Biological Sciences” in InnoativeIndia Rises: 244-246, Editor: L. K. Sharma, Medialand London. 53. Mittal, A. and J. Bentz. 2004. Chapter titled "Viral Fusion Mechanisms" in The Structure of Biological Membranes, 2nd edition: 511-528, Editor: P. Yeagle, CRC Press. Books and Edited Volumes 1. Bansal, M., B. Jayaram and A. Mittal. 2012. Guest Editors: Special issue on Nucleic acids in disease and disorder, J. Biosci., Vol. 37(3): 375-577, Indian Academy of Sciences and Springer, pp. 202. PATENTS AND TECHNOLOGY TRANSFER 1. Sharma, S., S. N. Naik, A. Mittal, N. Sabir and A. Sharma. A composition for enhancement of pathogenicity of Paecilomyces lilacinus and uses thereof. Application no. 3590/DEL/2013 (filed 10/12/2013; published 12/06/2015). 2. Sharma A., S. Sharma, S. N. Naik, N. Sabir and A. Mittal. A composition for enhancement of pathogenicity of Paecilomyces lilacinus – Technology transferred (through license agreement by FITT, IIT Delhi dated 30th June 2017) to Care Pro Bioscience Private Limited, I-59, U.P.S.I.D.C., Surajpur Site V, Kasna, Gautam Buddh Nagar, Greater Noida, Uttar Pradesh – 201308. MISCELLANEOUS 1. A. Mittal. 2016. ‘Tis the season - Of viral fevers, chikungunya, dengue, brain fevers, even diabetes? Nature India | Indigenus 16 Sep 2016 | 09:29 BST (http://blogs.nature.com/indigenus/2016/09/tis-theseason-of-dengue-chikungunya.html) 2. A. Mittal. 2011. Signatures of spatial organizations – From the universe of proteins to the universe in general. Nature Precedings, doi:10.1038/npre.2011.6038.1.

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Aditya Mittal

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RESEARCH THESIS SUPERVISION (Ongoing/incomplete work not listed) Doctoral 1. Assessing diagnostic approaches with clinical data on Human Immunodeficiency Virus infected Tuberculosis patients at National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India. (2017, Dr. (Ms.) Upasna Agarwal, MD). 2. Extraction of unbiased and universal signatures from three-dimensional structures of naturally occurring soluble proteins. (2017, Ms. Chanchal Acharya). 3. Deriving functional signatures of membrane proteins from their transmembrane domains. (2017, Ms. Snigdha Singh). 4. Development of scoring functions for predicting protein structures and functions. (2016, Mr. Avinash Mishra, jointly supervised by B. Jayaram). 5. Functional assembly of biological membranes: A structural approach. (2016, Ms. Suneyna Bansal). 6. Production and characterization of bacterial nano-magnets. (2011, Mr. Mohit Naresh). 7. Probing molecular interactions of PLGA particles with cell membranes for the delivery of pharmaceuticals. (2009, Ms. Roohi Gupta). M. Sc. (Chemistry) 1. FRET Based Experimental Investigation of Solute Structure in Aqueous Solution. (2010, Ms. Vrinda Khetarpal). 2. Biological self-assembly. (2009, Ms. Aditi Gupta). 3. Kinetics of F1 ATPase: Is this “Splendid Molecular Machine” really an enzyme? (2005, Mr. Srikanth Iyer). M. Tech. (Biochemical Engineering and Biotechnology) 1. Characterizing the biological membranes of magnetotactic bacteria. (2009, Miss. Preeti Shrimal). 2. Studies on cultivation of magnetotactic bacteria. (2008, Mr. Vivek Hasija, BOSS Award for Best experimental M. Tech. work in Biochemical Engineering and Biotechnology). 3. Experimental studies on engineering of liposomal preparations. (2008, Mr. Rahul Grover). 4. Delivery of molecules to cancer cells using liposomes. (2007, Miss. Vibhuti Gupta). 5. Microbial nanomagnetite production. (2007, Miss. Megha Sharma, BOSS Award for Best experimental M. Tech. work in Biochemical Engineering and Biotechnology). 6. Studies on Fluorescent iron-biosensor development. (2007, Mr. Varun Gupta). 7. Building a peptide library using enzymatic hydrolysis of some naturally available proteins (2007, Miss. Rashi Goyal). 8. Characterization of entrapment efficiency of liposomes. (2007, Mr. Rajat Khanna). 9. Theoretical Analysis of Molecular Shapes of Lipids for Engineering Liposomes. (2006, Mr. Vikas Bansal). 10. Encapsulation studies on biodegradable polymer (PLGA) particles. (2006, Mr. Shubhendu Pathak). Selected Under-graduate research alumni from the group 1. Ashesh (2013, B. Tech., Comp. Sc.) 2. Saurabh Anand (2013, B. Tech., Comp. Sc.) 3. Anshul Jain (2013, Int. M. Tech., Mathematics and Computing) 4. Harvineet Singh (2013, Int. M. Tech., Mathematics and Computing) 5. Deepak Vasisht (2012, B. Tech., Comp. Sc.) 6. Mohit Kumar (2012, B. Tech., Electrical Engg.) 7. Ankit Tomar (2011, B. Tech., Comp. Sc.) 8. Ankur Dahiya (2011, B. Tech., Comp. Sc.) 9. Swapnil Jain (2011, B. Tech., Comp. Sc.) 10. Deepak Menon (2009, B. Tech., Biotech., Amity) 11. Sucheta Arora (2009, B.Tech, M. Tech., DBEB) 12. Vidya Bhat (2009, B.Tech, M. Tech., DBEB) 13. Anshul Rana (2009, B.Tech, M. Tech., DBEB)

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INVITED LECTURES & REFEREED CONFERENCE ABSTRACTS (Not accepting invitations for lectures/talks in 2017 and 2018 due to other professional commitments) 1.

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A. Mittal. 2016. Invited lecture: Peeking into the “small” of the living world towards exploring biological selfassembly. NCERT Nurturance Programme for National Talent Search (NTS) Awardees, IIT Delhi, November 29 – December 1. A. Mittal. 2016. Invited lecture: Transmembrane domain lengths as signatures of organismal complexity. MBU, Indian Institute of Science (IISc) Bangalore, May 12. A. Mittal. 2016. Invited lecture: Transmembrane domain lengths as signatures of organismal complexity. Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, March 14. A. Mittal. 2016. Invited lecture: Transmembrane domain lengths as signatures of organismal complexity. International Symposium “Accelerating Biology 2016: Decoding the Deluge”, C-DAC, Pune, Maharashtra, January 19-21. Singh, S.* and A. Mittal. 2015. Transmembrane Domains of Viral Proteins Show Signatures of Entry and Exit Mechanisms. MCB75: from Molecules to Organisms, Indian Institute of Science (IISc), Bengaluru, India, December 11-14. Poster No. 49, Book of Abstracts MBC75: Pg95. A. Mittal. 2015. Invited lecture: Teaching Biology as a core course at IIT Delhi: Concept of Open Book, Open Notes, Open Web evaluations. Workshop for senior biology teachers, Navy Children School, Chanakyapuri, New Delhi, May 6. Bansal, S.* and A. Mittal. 2014. On the symbiotic origins of eukaryotic plasma membranes. American Society for Cell Biology Annual Meeting (2014 ASCB/IFCB Meeting), Philadelphia, PA, USA, December 6-10. Mol. Biol. Cell 25: P1322. A. Mittal. 2014. Invited lecture: Geometric universalities and stoichiometric constraints in naturally occurring folded proteins. Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, March 21. A. Mittal. 2014. Invited lecture: Peeking into the “small” of the living world towards exploring biological selfassembly. “Scintillations” – The Inter-college science festival of Gargi College, Delhi University, February 1920. A. Mittal. 2013. Invited lecture: Reflections on the 2013 Nobel Prize in Physiology and Medicine, IIT Delhi, October 31. Dhingra, P., A. Mishra*, R. Kaushik, M. Hassan, P. Rana, A. Mittal and B. Jayaram. 2013. Going Beyond ‘Lamarckism’ in Protein Tertiary Structure Prediction. Albany 2013: Conversation 18, SUNY Albany, USA, June 11-15. A. Mittal. 2013. Invited lecture: A geometrical interpretation of parametric universality in protein structures. Refresher course in Interdisciplinary Basic Sciences, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia (Central University) Jamia Nagar, New Delhi India, May 18. A. Mittal. 2013. Invited lecture: Geometric understanding and applications of universal spatial organization of naturally occurring folded proteins. Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, April 11. A. Mittal. 2013. Invited lecture: Dynamics and self-assembly in biological systems: Peeking into the "small" of the living world. Indian Institute of Technology Roorkee, Uttarakhand, March 16. A. Mittal. 2013. Invited lecture: A geometrical interpretation of parametric universality in protein structures. National Symposium “Ramachandran Manifestation: Peptide to Proteome” organized by Dept. of Biochemistry, Sri Venkateswara College and Dept. of Biochemistry, Delhi University, South Campus, New Delhi, March 1415. A. Mittal. 2013. Invited lecture: A geometrical interpretation of parametric universality in protein structures. International Symposium “Accelerating Biology 2013: The next wave”, C-DAC, Pune, Maharashtra, February 20-22. A. Mittal. 2012. Invited lecture: Signatures of spatial organization in the universe of proteins. National Conference on “New Trends in Bioinformatics”, IIT Delhi, July 30-31. A. Mittal. 2012. Invited lecture: Newest view on protein folding: Analytical and experimental evidence towards a paradigm shift. Refresher course in Interdisciplinary Basic Sciences, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia (Central University) Jamia Nagar, New Delhi India, May 12. A. Mittal. 2012. Invited Keynote lecture: Biological (r)Evolution at IIT Delhi. Open House - i2tech 2012, IIT Delhi, April 21. A. Mittal. 2012. Invited lecture: Wireless technology in medicine and applications in the developing world. Indo-US Telestroke Meeting, University of Massachusetts, Worcester, MA, USA, April 6-8. A. Mittal. 2012. Invited lecture: Newest view on protein folding: Analytical and experimental evidence towards a paradigm shift. National Seminar on Drug Design and Its Industrial Applications, Interdisciplinary

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Programme in Life Science & Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry, India, March 7-9. A. Mittal. 2012. Invited lecture: Newest view on protein folding: Analytical and experimental evidence towards a paradigm shift. Bioepoch 2012, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, February 24-25. A. Mittal. 2012. Invited lecture: Newest view on protein folding: Analytical and experimental evidence towards a paradigm shift. Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, February 22. A. Mittal. 2012. Invited lecture: Role of “blood brain barrier (BBB)” after HIBI: A window of opportunity for intervention after HIBI? ICMR Workshop on Hypoxic-Ischemic Brain Injury, AIIMS, New Delhi, February 45. B. Jayaram and A. Mittal. 2011. Universality of the spatial distribution of the backbones and a narrow band of amino acid stoichiometries amidst the structural and functional diversity of folded proteins. Albany 2011: Conversation 17, SUNY Albany, USA, June 14-18. J. Biomol. Struct. Dyn. 28: 998. A. Mittal. 2011. Invited lecture: Newest view of Protein folding. AIIMS, New Delhi, February 25. A. Mittal. 2010. Invited lecture: Newest view of Protein folding. 2nd Indo-Japan Symposium on Bioinformatics, IIT Delhi, December 10-11. A. Mittal. 2010. Invited lecture: Quantitative analyses of molecular interactions: Extracting stoichiometry and binding constants from experimental data. AIIMS, New Delhi, December 9. A. Mittal. 2010. Invited lecture: Biological Self-assembly. AIIMS, New Delhi, April 3. A. Mittal. 2009. Invited lecture: Analytical imaging in biological engineering. National Institute of Technical Teachers and Training & Research (NITTTR), Chandigarh, November 25. Mittal, A.* and R. Grover. 2009. Experimental Studies on Engineering of Liposomal Preparations. International Conference on Materials for Advanced Technologies (ICMAT 2009), Singapore from June 28 – July 3. Naresh, M.*, M. Sharma, A. Mittal. 2009. Biological synthesis and characterization of cubo-octahedral nanomagnets. International Conference on Materials for Advanced Technologies (ICMAT 2009), Singapore from June 28 – July 3. A. Mittal. 2009. Invited lecture: Bacterial nanomagnets: A fascinating example of biological assembly. AIIMS, New Delhi, March 15. A. Mittal. 2009. Invited lecture: Bacterial nanomagnets: A fascinating example of biological assembly. ISTE/AICTE (India) sponsored training program on “Recent Trends in Drug Development - A Focus on Novel Drug Delivery Systems” at P.D.M. College of Pharmacy, Sarai Aurangabad, Bahadurgarh, from February 2-6. A. Mittal. 2008. Invited lecture: Bacterial nanomagnets: A fascinating example of biological assembly. National Symposium on Nano-Biotechnology organized by Seshadripuram First Grade College, Bangalore, Karnataka, India, in association with Department of IT, Biotechnology, S & T, Govt. of Karnataka, from August 25-28. A. Mittal. 2008. Invited lecture: Bacterial nanomagnets: A fascinating example of biological assembly. Continuing Education Program on Nanomaterials, Defence Research and Development Organization (DRDO), New Delhi, August 28. A. Mittal. 2008. Invited lecture: Biological Nanosystems: Peeking into the “Small” Living World. Workshop on Laser Spectroscopy and Nanophotonics, organized by FITT, IIT Delhi, from March 14-15. A. Mittal. 2008. Invited lecture: Unraveling Cellular Geography for Drug Delivery: In vitro Spatio-temporal Deconvolution. 8th International symposium on Advances in Technology and Business Potential of New Drug Delivery Systems, organized by the Controlled Release Society Indian Chapter in Ahmedabad, Gujarat, India from February 26-27. A. Mittal. 2007. Invited lecture: Biological Nanosystems: Peeking into the “Small” Living World. International symposium titled “Science of Life: The New Horizon”, organized by Miranda House, University of Delhi, in New Delhi, India from November 21-23. A. Mittal. 2007. Invited lecture: Micron and nano-scale targeting in biological systems. The 5th Global Knowledge Millennium Summit B2B in Biotechnology & Nanotechnology, organized by the Associated Chambers of Commerce and Industry of India (ASSOCHAM), in New Delhi, India from September 18-21. Bansal, V., V. Gupta and A. Mittal*. 2007. Engineering of Liposomes: From Lipid Molecular Shapes to SubMicron Vesicles. The 4th International Conference on Materials for Advanced Technologies (ICMAT 2007), Singapore from July 1-6. A. Mittal. 2007. Regulating Nanopores: Lessons from Viral Fusion. The 4th International Conference on Materials for Advanced Technologies (ICMAT 2007), Singapore from July 1-6.

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[email protected]

43. R. Gupta*, P. Mishra and A. Mittal. 2007. Cellular Uptake of Biodegradable Nanoparticles by HeLa cells. The 4th International Conference on Materials for Advanced Technologies (ICMAT 2007), Singapore from July 16. 44. A. Mittal. 2007. Invited lecture: Fluorescence microscopy: Principles and Applications in Drug Delivery Research. First summer school on “Nanotechnology in Advanced Drug Delivery” organized by NIPER, S. A. S. Nagar, Punjab, India from May 1-5. 45. A. Mittal. 2007. Invited lecture: Nanotechnology: Principles and application to medicine. Molecular Medicine module of M. Biotechnology at the AIIMS, New Delhi, April 14. 46. A. Mittal. 2007. Invited lecture: Bacterial Nanomagnets. Workshop on “Nanotechnology – Current Status and Challenges” organized by Foundation for Innovation and Technology Transfer, IIT-Delhi from March 17-18. 47. A. Mittal. 2007. Invited lecture: Bacterial Nanomagnets. Workshop on “Biomaterials for Medical Devices and Drug Delivery” organized by Dept. of Biotechnology, Govt. of India, at IIT-Delhi from February 17. 48. A. Mittal. 2007. Invited lecture: In vitro Functional Validation of Nanoformulations for Drug Delivery. Nanotechnology Enclave organized by the Confederation of Indian Industries (CII) and, the Department of Science and Technology, Govt. of India, in New Delhi, India from February 15-16. 49. Gupta, V.*, V. Jangra and A. Mittal. 2006. Preparation and Characterization of Liposomes from Bacterial Lipids. CHEMCON 2006, The 56th Annual Conference of Indian Institute of Chemical Engineers, Ankleshwar, Gujrat, India from December 27-30. 50. Arora, S.*, V. Bhat and A. Mittal. 2006. Correlating single cell motility with population growth dynamics for flagellated bacteria. CHEMCON 2006, The 56th Annual Conference of Indian Institute of Chemical Engineers, Ankleshwar, Gujrat, India from December 27-30. 51. A. Mittal. 2006. Invited lecture: Engineering Challenges in Drug Delivery: From Nanopores to Nanoparticles. Indo-US Symposium on Nanotechnology in Advanced Drug Delivery, NIPER, S. A. S. Nagar, Punjab, India from October 5-6. 52. Sharma, M.*, M. Naresh and A. Mittal. 2006. Morphological changes in magnetotactic bacteria in presence of magnetic fields. Indo-US Symposium on Nanotechnology in Advanced Drug Delivery, NIPER, S. A. S. Nagar, Punjab, India from October 5-6. 53. Gupta, R.*, P. Mishra and A. Mittal. 2006. Monitoring uptake and degradation of PLGA nanoparticles using fluorescence microscopy. Indo-US Symposium on Nanotechnology in Advanced Drug Delivery, NIPER, S. A. S. Nagar, Punjab, India from October 5-6. 54. A. Mittal. 2006. Invited lecture: New Perspective of Bioprocess Engineering: Emerging Paradigm of Scaledown. National seminar on “Emerging trends in Bioprocess and Food Processing Industries” at HBTI Kanpur, UP, India from March 25-26. 55. Gupta, R.*, M. Sharma* and A. Mittal. 2006. Effects of Phospholipid Density in Nanopropeller Driven Bacterial Motion. International Conference on Nanoscience and Technology (ICONSAT2006), India Habitat Center, New Delhi, India from March 16-18. 56. Podbilewicz, B*., G. Shemer, M. Suissa, T. Gattegno, A. Mittal, C. Valansi, K. C. Q. Nguyen, D. H. Hall and L. V. Chernomordik. 2005. Dissection of syncytiogenesis: EFF-1 proteins fuse cells from beginning to end. European Life Scientist Organization (ELSO) Meeting, Dresden, Germany from September 3-6. Abstract: 463. 57. Podbilewicz, B.*, T. Gattegno, A. Mittal, C. Valansi, K. C. Q. Nguyen, D. H. Hall and L. V. Chernomordik. 2005. Syncytiogenesis: EFF-1 proteins fuse cells from beginning to end. International Worm Meeting, University of California, LA, USA from June 25-29. Citation ID 11988761, WBPaper00006396. 58. Mittal, A.*, T. Gattegno, L. V. Chernomordik and B. Podbilewicz. 2005. Kinetic Mapping of Developmental Cell Fusion in Live C. elegans Embryos. Gordon Conference on Molecular Membrane Biology, Proctor Academy, Andover, NH, USA from July 10–15. 59. Mittal, A. 2005. Invited seminar: From Kinetics to Molecular Machines: Unraveling Biological Membrane Fusion. National Technology Day celebration at IIT-Delhi. 60. Mittal, A. 2005. Invited Poster: Exhausting the Options by Exhaustive Fitting: From Kinetics to Molecular Machines in Biological Systems. The first Indo-US Frontiers of Science Symposium organized by National Academy of Sciences, USA and the Indo-US S&T forum, Jan. 8-11, at IISc Bangalore, India. 61. Mittal, A. 2004. Invited seminar: From Kinetics to Molecular Machines: The Case of Influenza HemagglutininMediated Membrane Fusion. The first Indo-US joint conference in chemical engineering (Global Environment in Chemical Engineering) organized by IIChE and AIChE in concurrence with the annual IIChE conference (Chemcon 2004), Dec. 27-30, Mumbai, India. 62. Gattegno, T., G. Shemer, A. Mittal, M. Suissa, C. Valansi, I. Kolotuev, K. C. Q. Nguyen, D. H. Hall , L. V. Chernomordik and B. Podbilewicz*. 2004. Poster: Cell Fusion in C. elegans: What have we learned from viral fusion? 4th Frederick Workshop on the Cell Biology of Viral Entry, National Cancer Institute, Frederick, MD, USA.

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[email protected]

63. Mittal, A.*, B. Podbilewicz and L. V. Chernomordik. 2004. Characterizing kinetics of cell fusion in developing C. elegans embryos. The Biophysical Society Annual Meeting, Baltimore, MD. Biophys. J. 86(1), Part 2 (229A): 45a. 64. Tran, T. T.*, A. Mittal and J. Bentz. 2004. The elementary mass action rate constants of P-gp transport across a confluent MDCKII-hMDR1 cell monolayer obtained by exhaustive fitting. The Biophysical Society Annual Meeting, Baltimore, MD. Biophys. J. 86(1), Part 2 (3176A): 612a. 65. Zaitseva, E.*, E. Leikina, A. Mittal and L. V. Chernomordik. 2004. Structurally diverse Sindbis virus E1 protein and influenza virus hemagglutinin drive cell fusion through similar membrane intermediates. The Biophysical Society Annual Meeting, Baltimore, MD. Biophys. J. 86(1), Part 2 (215A): 43a. 66. Mittal, A.*, B. Podbilewicz and L. V. Chernomordik. 2003. Kinetics of Cell Fusion in Developing C. elegans Embryos. The American Society for Cell Biology Annual Meeting, San Francisco, CA. Late Abstract (L224). 67. Mittal, A.*, E. Leikina, L. V. Chernomordik and J. Bentz. 2003. Kinetically Differentiating Influenza Hemagglutinin Fusion and Hemifusion Machines. Gordon Conference in Molecular Membrane Biology, Proctor Academy, Andover, NH from July 13–18. 68. Mittal, A.*, E. Leikina, L. V. Chernomordik and J. Bentz. 2003. Kinetic Differentiation of HA Fusion and Hemifusion. The Biophysical Society Annual Meeting, San Antonio, TX. Biophys. J. 84(2), Supp.(195A): 948a. 69. Leikina, E.*, A. Mittal, M. M. Kozlov and L. V. Chernomordik. 2003. Fusion Proteins Located Outside of the Contact Zone are Involved in Membrane Fusion. The Biophysical Society Annual Meeting, San Antonio, TX. . Biophys. J. 84(2), Supp.(194A): 947a. 70. L.V.Chernomordik*, M.M.Kozlov, E.Leikina, I. Markovic, A. Mittal, C. Ramos, M. Zhukovsky and J. Zimmerberg. 2003. Protein-lipid interplay in fusion mediated by influenza virus hemagglutinin. (Symposium by L. V. Chernomordik) The Biophysical Society Annual Meeting, San Antonio, TX. Biophys. J. 84(2), Supp.(11A): 49-Symp. 71. Mittal, A.*, E. Leikina,L. V. Chernomordik and J. Bentz. 2002. Kinetics and phenotypes of fusion and hemifusion of HA expressing cells with RBCs resolved by automated video microscopy. 3rd Frederick Workshop on the Cell Biology of Viral Entry, National Cancer Institute, Frederick, MD. 72. Mittal, A.*, E. Leikina,L. V. Chernomordik and J. Bentz. 2001. Monitoring Single Cell Fusion Kinetics from Automated Video Fluorescence Microscopy. The American Society for Cell Biology Annual Meeting Washington, DC. Mol. Biol. Cell 12,Supp.(404A): 74a. 73. Mittal, A.* and J. Bentz. 2001. Influenza Hemagglutinin Mediated Membrane Fusion: Minimal Aggregate Size, Minimal Fusion Unit and Role of Sialate Binding. The Annual Research Day of Drexel and MCP Hahnemann universities, Philadelphia, PA. (Best Poster Award) 74. Bentz, J.*, A. Mittal, E. Leikina, and L. V. Chernomordik. 2001. Kinetics of RBC Fusion with Influenza Hemagglutinin-expressing Cells as a Function of Technique. The Biophysical Society Annual Meeting, Boston, MA. Biophys. J. 80(1), Part 2(1770A): 417a. 75. Mittal, A.* and J. Bentz. 2001. Role of Sialate Bound Influenza Hemagglutinin during Fusion. The Biophysical Society Annual Meeting, Boston, MA. Biophys. J. 80(1), Part 2(1774A): 418a. (Finalist: Student Research Achievement Award) 76. Mittal, A.* and J. Bentz. 2000. Kinetics of Lipidic Channel Formation in Influenza Hemagglutinin-mediated Membrane Fusion. The Annual Drexel and MCP Hahnemann University Research Day in association with the 12th Annual Sigma-Xi Research Symposium, Philadelphia, PA. (Best Poster Award) 77. Manvendra* and A. Mittal. 1995. Treatment of Distillery effluent. Invited talk at The Annual National Student Seminar of Osmania University, Hyderabad, India. 78. Mittal, A. 1995. Interferon X Protoplast fusion. A reviewed paper presentation at TRYST: The Annual Student Seminar of I.I.T., Delhi, India.

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