May 23, 2002 - lane Ave., SL-38, New Orleans, LA 70112. Phone: (504) ... kindly donated by John Balliet and Priscilla Schaffer (Harvard University, Bos- ton).
Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1 Bruno Sainz, Jr., and William P. Halford* Department of Microbiology and Immunology, Tulane University Health Sciences Center, Program in Molecular Pathogenesis and Immunity, New Orleans, Louisiana 70112 Received 23 May 2002/Accepted 14 August 2002
In vivo evidence suggests that T-cell-derived gamma interferon (IFN-␥) can directly inhibit the replication of herpes simplex virus type 1 (HSV-1). However, IFN-␥ is a weak inhibitor of HSV-1 replication in vitro. We have found that IFN-␥ synergizes with the innate IFNs (IFN-␣ and -) to potently inhibit HSV-1 replication in vitro and in vivo. Treatment of Vero cells with either IFN- or IFN-␥ inhibits HSV-1 replication by
