Amino Acids and Their Derivatives

Amino Acids and Their Derivatives

　

Fmoc-L-Amino Acids and Fmoc-Peptides …………… 292 Fmoc-D-Amino Acids ………………………………… 295 　

Acids for Peptide Synthesis ………………… 297 Acids for Peptide Synthesis………………… 299 Amino Acid Derivatives and Esters ………………… 301 L-Amino

D-Amino

– 283 –

Amino Acids Derivatives

Boc-L-Amino Acids …………………………………… 284 Boc-D-Amino Acids …………………………………… 288 Z-Amino Acids ………………………………………… 291

Boc-L-Amino Acids Optical purity of Boc-L-amino acid is determined by RP-HPLC using chiral derivatization method. Homogeneity of Boc-group is determined by gas-chromatographic method, and the purity grade of products is guaranteed according to our Purity Criteria on page III (XV). Code

Compound

Grade

2051

Boc-Ala

2～10

t-Butyloxycarbonyl-L-alanine

　 (M.W. 189.21)

C8H15NO4

Boc-β-Ala

2～10

t-Butyloxycarbonyl-β-alanine

　 (M.W. 189.21)

C8H15NO4

Boc-Arg(NO2)*

-20

N α-t-Butyloxycarbonyl-N g-nitro-L-arginine C11H21N5O6

Boc-Arg(Tos)*

2～10

N α-t-Butyloxycarbonyl-N g-tosyl-L-arginine C18H28N4O6S

Boc-Asn

2～10

t-Butyloxycarbonyl-L-asparagine C9H16N2O5

Boc-Asn-ONp

-20

t-Butyloxycarbonyl-L-asparagine p-nitrophenyl ester C15H19N3O7

Boc-Asp(OBzl)

2～10

t-Butyloxycarbonyl-L-aspartic acid β-benzyl ester C16H21NO6

Boc-Asp(OcHex)

2～10

t-Butyloxycarbonyl-L-aspartic acid β-cyclohexyl ester C15H25NO6

AA-A

5g 25 g 100 g

2,800 9,000 27,000

AA

5g 25 g 100 g

4,000 13,500 47,000

AA-A

5g 25 g 100 g

1,500 3,300 10,000

B

5g 25 g 100 g

9,000 36,000 126,000

AA

5g 25 g 100 g

2,500 6,000 20,000

AA

5g 25 g 100 g

2,500 6,000 20,000

[7536-58-5]

2132

　 (M.W. 315.36)

2,000 5,000 17,000

[4587-33-1]

2059

　 (M.W. 323.34)

5g 25 g 100 g

[7536-55-2]

2077

　 (M.W. 353.33)

AA

[13836-37-8]

2060

　 (M.W. 232.23)

1,500 3,000 9,000

[2188-18-3]

2125

　 (M.W. 428.50)

5g 25 g 100 g

[3303-84-2]

2058

　 (M.W. 319.31)

AA [15761-38-3]

2131

Price:Yen

[73821-95-1]

1) J.P. Tam, T.-W. Wong, M.W. Riemen, F.-S. Tjoeng, and R.B. Merrifield, Tetrahedron Lett., 42, 4033 (1979).

2121

Boc-Cys(Acm)

2～10

t-Butyloxycarbonyl-S-acetamidomethyl-L-cysteine (M.W. 292.35)

AA C11H20N2O5S

[19746-37-3]

5g 25 g 100 g

3,000 11,000 33,000

1) D.F. Veber, J.D. Milkowski, S.L. Varga, R.G. Denkewalter, and R. Hirschmann, J. Am. Chem. Soc., 94, 5456 (1972). 2) 　 B. Kamber, A. Hartmann, K. Eisler, B. Riniker, H. Rink, P. Sieber, and W. Rittel, Helv. Chim. Acta, 63, 899 (1980).

*

These compounds typically co-crystallize with between

1/ 4

- 1 molecule of water and / or ethyl acetate per molecule of amino acid

derivatives. The exact analytical data are provided to customers with each shipment.

– 284 –

Boc-L-Amino Acids (continued) Code

Compound

2061

Boc-Cys(Bzl)

2～10

t-Butyloxycarbonyl-S-benzyl-L-cysteine

　 (M.W. 311.40)

Grade

C15H21NO4S

Boc-Cys(But )

2～10

t-Butyloxycarbonyl-S-t-butyl-L-cysteine

　 (M.W. 277.38)

C12H23NO4S

Boc-Cys(4-CH3Bzl)

2～10

t-Butyloxycarbonyl-S-4-methylbenzyl-L-cysteine C16H23NO4S

5g 25 g 100 g

3,000 11,000 33,000

AA

5g 25 g 100 g

4,000 13,500 47,000

AA

5g 25 g 100 g

3,200 12,000 36,000

5g 25 g 100 g

3,200 12,000 36,000

AA-A

5g 25 g 100 g

1,800 4,500 15,000

A-B

5g 25 g 100 g

9,000 36,000 126,000

AA

5g 25 g 100 g

2,500 6,000 20,000

AA

5g 25 g 100 g

2,500 6,000 20,000

[56976-06-8]

2129

　 (M.W. 325.42)

AA [5068-28-0]

2130

Price:Yen

[61925-77-7]

1) W.F. Heath, J.P. Tam, and R.B. Merrifield, Int. J. Pept. Protein Res., 28, 498 (1986).

2078

Boc-Cys(MBzl)

2～10

t-Butyloxycarbonyl-S-p-methoxybenzyl-L-cysteine

　 (M.W. 341.42)

C16H23NO5S

AA [18942-46-6]

1) M. Platen and E. Steckhan, Liebigs Ann. Chem., 9, 1563 (1984).

2062

Boc-Gln

2～10

t-Butyloxycarbonyl-L-glutamine

　 (M.W. 246.26)

C10H18N2O5

[13726-85-7]

Boc-Gln-ONp

-20

t-Butyloxycarbonyl-L-glutamine p-nitrophenyl ester

　 (M.W. 367.35)

C16H21N3O7

[15387-45-8]

2103

Boc-Glu(OBzl)

2～10

t-Butyloxycarbonyl-L-glutamic acid γ-benzyl ester

　 (M.W. 337.37)

C17H23NO6

[13574-13-5]

2134

Boc-Glu(OcHex)

2～10

t-Butyloxycarbonyl-L-glutamic acid γ-cyclohexyl ester

　 (M.W. 329.39)

C16H27NO6

[73821-97-3]

1) J.P. Tam, T.-W. Wong, M.W. Riemen, F.-S. Tjoeng, and R.B. Merrifield, Tetrahedron Lett., 42, 4033 (1979).

2054

Boc-Gly

2～10

t-Butyloxycarbonylglycine

　 (M.W. 175.18)

C7H13NO4

Boc-His(Bom)

2～10

N α-t-Butyloxycarbonyl-N π-benzyloxymethyl-L-histidine C19H25N3O5

5g 25 g 100 g

1,500 3,000 9,000

AA

5g 25 g 100 g

10,000 40,000 140,000

5g 25 g 100 g

5,000 18,000 60,000

[4530-20-5]

2138

　 (M.W. 375.42)

AA

[79950-65-5]

1) T. Brown, J.H. Jones, and J.D. Richards, J. Chem. Soc. Perkin Trans I, 1982, 1553.

2109

Boc-His(Tos)

-20

N α-t-Butyloxycarbonyl-N τ-tosyl-L-histidine (M.W. 409.46)

A C18H23N3O6S

[35899-43-5]

　

– 285 –


2079


Compound

Grade

2116

Boc-Hyp(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-L-hydroxyproline

　 (M.W. 321.37) 1/ 2

C17H23NO5

Boc-Ile •

2～10

t-Butyloxycarbonyl-L-isoleucine hemihydrate

H2 O

　 (M.W. 231.29 • 9.01)

C11H21NO4 • 1/2 H2O

5g 25 g 100 g

8,000 30,000 105,000

AA

5g 25 g 100 g

1,500 3,000 9,000

AA

5g 25 g 100 g

1,500 3,000 9,000

AA

5g 25 g 100 g

4,500 16,000 56,000

AA

5g 25 g 100 g

3,000 11,000 33,000

AA

5g 25 g 100 g

1,500 3,300 10,000

AA

5g 25 g 100 g

1,500 3,000 9,000

AA

5g 25 g 100 g

1,500 3,000 9,000

AA

5g 25 g 100 g

2,700 8,000 24,000

AA

5g 25 g 100 g

3,200 12,000 42,000

AA

5g 25 g 100 g

3,200 12,000 42,000

A

5g 25 g 100 g

1,700 4,000 12,000

[13139-16-7]

2055

Boc-Leu • H2O

2～10

t-Butyloxycarbonyl-L-leucine monohydrate

　 (M.W. 231.29 • 18.02)

AA [54631-81-1]

2065

C11H21NO4 • H2O

[13139-15-6]

2135

Boc-Lys(Cl-Z)

2～10

N α-t-Butyloxycarbonyl-N ε-2-chlorobenzyloxycarbonyl-L-lysine

　 (M.W. 414.88)

C19H27N2O6Cl

[54613-99-9]

2108

Boc-Lys(Z)

2～10

N α-t-Butyloxycarbonyl-N ε-benzyloxycarbonyl-L-lysine

　 (M.W. 380.44)

C19H28N2O6

[2389-45-9]

2104

Boc-Met

2～10

t-Butyloxycarbonyl-L-methionine

　 (M.W. 249.33)

C10H19NO4S

[2488-15-5]

2068

Boc-Phe

2～10

t-Butyloxycarbonyl-L-phenylalanine

　 (M.W. 265.30)

C14H19NO4

[13734-34-4]

2056

Boc-Pro

2～10

t-Butyloxycarbonyl-L-proline

　 (M.W. 215.25)

C10H17NO4

[15761-39-4]

2120

Boc-Sar

2～10

t-Butyloxycarbonylsarcosine

　 (M.W. 189.21)

C8H15NO4

[13734-36-6]

2102

Boc-Ser(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-L-serine

　 (M.W. 295.33)

C15H21NO5

[23680-31-1]

2070

Boc-Thr(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-L-threonine

　 (M.W. 309.36)

C16H23NO5

[15260-10-3]

2057

Boc-Trp

2～10

N α-t-Butyloxycarbonyl-L-tryptophan (M.W. 304.34)

C16H20N2O4

[13139-14-5]

　

– 286 –

Price:Yen


Compound

2115

Boc-Trp(CHO)

2～10

N α-t-Butyloxycarbonyl-N in-formyl-L-tryptophan

　 (M.W. 332.35)

Grade

C17H20N2O5

AA [47355-10-2]

Price:Yen 5g 25 g 100 g

5,000 18,000 60,000

1) M. Ohno, S. Tsukamoto, S. Sato, and N. Izumiya, Bull. Chem. Soc. Jpn., 46, 3280 (1973).

2139

Boc-Trp(Hoc)

2～10

N α-t-Butyloxycarbonyl-N in-cyclohexyloxycarbonyl-L-tryptophan

　 (M.W. 430.49)

A C23H30N2O6

5g 25 g

50,000 200,000

[177897-92-6]

1) Y. Nishiuchi, H. Nishio, T. Inui, T. Kimura, and S. Sakakibara, Tetrahedron Lett., 37, 7529 (1996).

2114

Boc-Tyr(Br-Z)

2～10

t-Butyloxycarbonyl-O-2-bromobenzyloxycarbonyl-L-tyrosine

　 (M.W. 494.33)

A C22H24NO7Br

Boc-Tyr(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-L-tyrosine C21H25NO5

Boc-Tyr(Cl2-Bzl)

2～10

t-Butyloxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine C21H23NO5Cl2

AA

5g 25 g 100 g

5,000 18,000 60,000

AA

5g 25 g 100 g

4,500 16,000 56,000

[2130-96-3]

2119

　 (M.W. 440.32)

5,300 19,000 68,000

[47689-67-8]

2071

　 (M.W. 371.43)

5g 25 g 100 g

[40298-71-3]

2105

Boc-Val

2～10

t-Butyloxycarbonyl-L-valine

　 (M.W. 217.26)

AA C10H19NO4

[13734-41-3]

– 287 –

5g 25 g 100 g

1,500 3,000 9,000


1) D. Yamashiro and C.H. Li, J. Am. Chem. Soc., 95, 1310 (1980). 2) Y. Kiso, M. Satomi, K. Ukawa, and T. Akita, J. Chem. Soc. Chem. Commun., 22, 1063 (1980).

Boc-D-Amino Acids The amount of L-amino acid in each compound is determined in our laboratory and the data are provided to customers with each shipment. All products are purified to avoid contamination with the sec-Boc-amino acid derivatives and the purity grade of products is guaranteed according to our Purity Criteria on page III (XV). Code

Compound

Grade

2606

Boc-D-Ala

AA

2～10

t-Butyloxycarbonyl-D-alanine

1g 5g 25 g

2,000 3,000 10,000

AA

1g 5g 25 g

3,000 12,000 42,000

AA-A

1g 5g 25 g

4,500 16,000 64,000

B

1g 5g 25 g

5,500 20,000 80,000

AA

1g 5g 25 g

3,500 12,000 42,000

AA

1g 5g 25 g

3,500 12,000 42,000

AA

1g 5g 25 g

8,000 32,000 128,000

AA-A

1g 5g 25 g

3,000 12,000 48,000

A-B

1g 5g 25 g

5,500 20,000 80,000

　 (M.W. 189.21)

C8H15NO4

[7764-95-6]

2609

Boc-D-Arg(Tos)*

2～10

N α-t-Butyloxycarbonyl-N g-tosyl-D-arginine

　 (M.W. 428.50)

C18H28N4O6S

[61315-61-5]

2626

Boc-D-Asn

2～10

t-Butyloxycarbonyl-D-asparagine

　 (M.W. 232.23)

C9H16N2O5

[75647-01-7]

2620

Boc-D-Asn-ONp

-20

t-Butyloxycarbonyl-D-asparagine p-nitrophenyl ester

　 (M.W. 353.33)

C15H19N3O7

[104199-82-8]

2616

Boc-D-Asp(OBzl)

2～10

t-Butyloxycarbonyl-D-aspartic acid β-benzyl ester

　 (M.W. 323.34)

C16H21NO6

[51186-58-4]

2617

Boc-D-Asp(OcHex)

2～10

t-Butyloxycarbonyl-D-aspartic acid β-cyclohexyl ester

　 (M.W. 315.36)

C15H25NO6

[112898-18-7]

2611

Boc-D-Cys(4-CH3Bzl)

2～10

t-Butyloxycarbonyl-S-4-methylbenzyl-D-cysteine

　 (M.W. 325.42)

C16H23NO4S

[61925-78-8]

2623

Boc-D-Gln

2～10

t-Butyloxycarbonyl-D-glutamine

　 (M.W. 246.26)

C10H18N2O5

[61348-28-5]

2621

Boc-D-Gln-ONp

-20

t-Butyloxycarbonyl-D-glutamine p-nitrophenyl ester (M.W. 367.35)

*

C16H21N3O7

[74086-23-0]

This compound 　 typically co-crystallizes with between

1/ 4

Price:Yen

- 1 molecule of water and / or ethyl acetate per molecule of amino acid derivative.

The exact analytical data are provided to customers with each shipment.

– 288 –

Boc-D-Amino Acids (continued) Code

Compound

Grade

2625

Boc-D-Glu(OBzl)

2～10

t-Butyloxycarbonyl-D-glutamic acid γ-benzyl ester

　 (M.W. 337.37)

C17H23NO6

Boc-D-His(Tos) • DCHA

2～10

N α-t-Butyloxycarbonyl-N τ-tosyl-D-histidine monodicyclohexylammonium salt

　 (M.W. 409.46 • 181.32) 1/ 2

C18H23N3O6S • C12H23N

2629

Boc-D-Ile •

2～10

t-Butyloxycarbonyl-D-isoleucine hemihydrate C11H21NO4 • 1/2 H2O

3,500 12,000 42,000

B

1g 5g 25 g

inquiry inquiry inquiry

AA

1g 5g

30,000 120,000

AA

1g 5g 25 g

2,000 4,000 16,000

AA

1g 5g 25 g

4,500 16,000 64,000

A

1g 5g 25 g

2,500 7,000 28,000

AA

1g 5g 25 g

2,000 3,000 12,000

AA

1g 5g 25 g

4,500 16,000 64,000

AA

1g 5g 25 g

4,000 15,000 62,000

AA

1g 5g 25 g

4,000 15,000 62,000

A

1g 5g 25 g

2,000 4,000 16,000

AA

1g 5g 25 g

4,000 14,000 56,000

[55721-65-8]

2603

Boc-D-Leu • H2O

2～10

t-Butyloxycarbonyl-D-leucine monohydrate

　 (M.W. 231.29 • 18.02)

1g 5g 25 g

[210694-29-4]

H2 O

　 (M.W. 231.29 • 9.01)

AA [35793-73-8]

2605

C11H21NO4 • H2O

[16937-99-8]

2628

Boc-D-Lys(Cl-Z)

2～10

N α-t-Butyloxycarbonyl-N ε-2-chlorobenzyloxycarbonyl-D-lysine

　 (M.W. 414.88 )

C19H27N2O6Cl

[57096-11-4]

Boc-D-Met

2～10

t-Butyloxycarbonyl-D-methionine

　 (M.W. 249.33)

C10H19NO4S

[5241-66-7]

2604

Boc-D-Phe

2～10

t-Butyloxycarbonyl-D-phenylalanine

　 (M.W. 265.30)

C14H19NO4

[18942-49-9]

2610

Boc-D-Pro

2～10

t-Butyloxycarbonyl-D-proline

　 (M.W. 215.25)

C10H17NO4

[37784-17-1]

2627

Boc-D-Ser(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-D-serine

　 (M.W. 295.33)

C15H21NO5

[47173-80-8]

2624

Boc-D-Thr(Bzl)

2～10

t-Butyloxycarbonyl-O-benzyl-D-threonine

　 (M.W. 309.36)

C16H23NO5

[69355-99-3]

2602

Boc-D-Trp

2～10

N α-t-Butyloxycarbonyl-D-tryptophan

　 (M.W. 304.34)

C16H20N2O4

[5241-64-5]

2614

Boc-D-Trp(CHO)

2～10

N α-t-Butyloxycarbonyl-N in-formyl-D-tryptophan (M.W. 332.35)

C17H20N2O5

[64905-10-8]

　

– 289 –


2608

Price:Yen

Boc-D-Amino Acids (continued) Code

Compound

2612

Boc-D-Tyr(Br-Z)

2～10

t-Butyloxycarbonyl-O-2-bromobenzyloxycarbonyl-D-tyrosine

　 (M.W. 494.33)

Grade

C22H24NO7Br

A

Boc-D-Tyr(Cl2-Bzl)

2～10

t-Butyloxycarbonyl-O-2,6-dichlorobenzyl-D-tyrosine

　 (M.W. 440.32)

C21H23NO5Cl2

2619

Boc-D-Val

2～10

t-Butyloxycarbonyl-D-valine

　 (M.W. 217.26)

C10H19NO4

1g 5g 25 g

4,500 16,000 64,000

AA

1g 5g 25 g

5,500 20,000 80,000

AA

1g 5g 25 g

2,000 6,000 21,000

[81189-61-9]

2622

[69541-62-4]

[22838-58-0]

– 290 –

Price:Yen

Z-Amino Acids The purity grade of the following products is guaranteed as described in our Purity Criteria on page III (XV). Code

Compound

2117

Z-Pyr

2～10

Benzyloxycarbonyl-L-pyroglutamic acid (N-Benzyloxycarbonyl-L-pyrrolidonecarboxylic acid)

　 (M.W. 263.25)

Grade

C13H13NO5

Z-D-Pyr

2～10

Benzyloxycarbonyl-D-pyroglutamic acid (N-Benzyloxycarbonyl-D-pyrrolidonecarboxylic acid) C13H13NO5

A

5g 25 g 100 g

7,500 20,000 60,000

AA

1g 5g 25 g

4,300 15,000 60,000

[32159-21-0]

2613

　 (M.W. 263.25)

Price:Yen

[78339-57-8]


– 291 –

Fmoc-L-Amino Acids and Fmoc-Peptides [1] L.A. Carpino and G.Y. Han, J. Org. Chem., 37, 3404 (1972). [2] L.A. Carpino, Acc. Chem. Res., 20, 401 (1987). [3] G. Barany, N. Kneib-Cordonier, and D.G. Mullen, Int. J. Pept. Protein Res., 30, 705 (1987).

The purity grade of the following products is guaranteed as described in our Purity Criteria on page III (XV). Code

Compound

2301

Fmoc-Ala • H2O

2～10

9-Fluorenylmethoxycarbonyl-L-alanine monohydrate

2350

New

2～10

Price:Yen

　 (M.W. 311.33•18.02)

C18H17NO4 • H2O

5g 25 g

2,000 8,000

1g

20,000

[35661-39-3]

Fmoc-Ala-Cys(Trt) 9-Fluorenylmethoxycarbonyl-L-alanyl-S-trityl-L-cysteine (M.W. 656.79)

C40H36N2O5S

　 Component of Cysteinyl Prolyl Ester (CPE) Autoactivation Unit 1) 2) 3) •

T. Kawakami and S. Aimoto, Chem. Lett., 36, 76 (2007). T. Kawakami and S. Aimoto, Tetrahedron Lett., 48, 1903 (2007). T. Kawakami and S. Aimoto, Tetrahedron, 65, 3871 (2009). This compound is produced by Peptide Institute, Inc. under the license of Osaka University and Osaka Foundation for Trade and Industry (previous: Osaka Industrial Promotion Organization).

2324

Fmoc-Arg(Pbf)

2～10

N α-9-Fluorenylmethoxycarbonyl-N g-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

　 (M.W. 648.77)

C34H40N4O7S

Fmoc-Asn

2～10

9-Fluorenylmethoxycarbonyl-L-asparagine C19H18N2O5

Fmoc-Asn(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N ω-trityl-L-asparagine C38H32N2O5

[132388-59-1]

2305

Fmoc-Asp(OBut )

2～10

9-Fluorenylmethoxycarbonyl-L-aspartic acid β-t-butyl ester

　 (M.W. 411.45)

C23H25NO6

[71989-14-5]

2322

Fmoc-Cys(Acm)

2～10

9-Fluorenylmethoxycarbonyl-S-acetamidomethyl-L-cysteine

　 (M.W. 414.47)

C21H22N2O5S

[86060-81-3]

2323

Fmoc-Cys(Trt)

2～10

9-Fluorenylmethoxycarbonyl-S-trityl-L-cysteine (M.W. 585.71)

C37H31NO4S

[103213-32-7]

2307

Fmoc-Gln 　

2～10

9-Fluorenylmethoxycarbonyl-L-glutamine (M.W. 368.38)

C20H20N2O5

5g 25 g

2,000 8,000

1g 5g 25 g

3,000 9,300 41,000

1g 5g 25 g

2,000 6,500 26,000

1g 5g 25 g

3,000 10,000 40,000

1g 5g 25 g

2,000 7,000 30,000

5g 25 g

2,000 7,000

[71989-16-7]

2325

　 (M.W. 596.67)

3,100 9,700 43,000

[154445-77-9]

2304

　 (M.W. 354.36)

1g 5g 25 g

[71989-20-3]

　

– 292 –

Fmoc-L-Amino Acids and Fmoc-Peptides (continued) Code

Compound

2326

Fmoc-Gln(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N ω-trityl-L-glutamine

　 (M.W. 610.70)

Price:Yen

C39H34N2O5

[132327-80-1]

2308

Fmoc-Glu(OBut ) • H2O

2～10

9-Fluorenylmethoxycarbonyl-L-glutamic acid γ-t-butyl ester monohydrate

　 (M.W. 425.47 • 18.02)

C24H27NO6 • H2O

2309

Fmoc-Gly

2～10

9-Fluorenylmethoxycarbonylglycine

2351

New

2～10

　 (M.W. 297.31)

C17H15NO4

1g 5g 25 g

3,000 9,300 41,000

1g 5g 25 g

2,000 8,000 36,000

5g 25 g

2,000 8,000

1g

20,000

[204251-24-1]

[29022-11-5]

Fmoc-Gly-Cys(Trt) 9-Fluorenylmethoxycarbonylglycyl-S-trityl-L-cysteine (M.W. 642.76)

C39H34N2O5S



Fmoc-His(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N τ-trityl-L-histidine [109425-51-6]

1g 5g 25 g

2,000 7,000 33,000

2311

Fmoc-Ile

2～10

9-Fluorenylmethoxycarbonyl-L-isoleucine

5g 25 g

2,000 8,000

5g 25 g

2,000 8,000

1g

20,000

　 (M.W. 619.71)

　 (M.W. 353.41)

C40H33N3O4

C21H23NO4

[71989-23-6]

2312

Fmoc-Leu

2～10

9-Fluorenylmethoxycarbonyl-L-leucine

2352

New

2～10

　 (M.W. 353.41)

C21H23NO4

[35661-60-0]

Fmoc-Leu-Cys(Trt) 9-Fluorenylmethoxycarbonyl-L-leucyl-S-trityl-L-cysteine (M.W. 698.87)

C43H42N2O5S



2313

Fmoc-Lys(Boc)

2～10

N α-9-Fluorenylmethoxycarbonyl-N ε-t-butyloxycarbonyl-L-lysine

　 (M.W. 468.54)

C26H32N2O6

[71989-26-9]

– 293 –

1g 5g 25 g

2,000 8,000 36,000


2310

Fmoc-L-Amino Acids and Fmoc-Peptides (continued) Code

Compound

2314

Fmoc-Met

2～10

9-Fluorenylmethoxycarbonyl-L-methionine

　 (M.W. 371.45)

Price:Yen

C20H21NO4S

Fmoc-Phe

2～10

9-Fluorenylmethoxycarbonyl-L-phenylalanine C24H21NO4

Fmoc-Pro

2～10

9-Fluorenylmethoxycarbonyl-L-proline C20H19NO4

2317 2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-L-serine C22H25NO5

[71989-33-8]

2318

t Fmoc-Thr(Bu ) 　

2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-L-threonine (M.W. 397.46)

C23H27NO5

[71989-35-0]

2319

　 Fmoc-Trp

2～10

N α-9-Fluorenylmethoxycarbonyl-L-tryptophan

　 (M.W. 426.46)

C26H22N2O4

Fmoc-Trp(Boc)

2～10

N α-9-Fluorenylmethoxycarbonyl-N in-t-butyloxycarbonyl-L-tryptophan C31H30N2O6 Purity: higher than 97%

[143824-78-6]

2320

Fmoc-Tyr(But )

2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-L-tyrosine

　 (M.W. 459.53)

C28H29NO5

[71989-38-3]

2321

Fmoc-Val

2～10

9-Fluorenylmethoxycarbonyl-L-valine

　 (M.W. 339.39)

C20H21NO4

5g 25 g

2,000 8,000

1g 5g 25 g

2,000 8,000 36,000

1g 5g 25 g

2,000 7,000 33,000

5g 25 g

2,000 8,000

1g 5g 25 g

3,300 11,100 47,100

1g 5g 25 g

2,000 7,000 33,000

5g 25 g

2,000 8,000

[35737-15-6]

2327

(M.W. 526.58)

2,000 8,000

[71989-31-6]

　 Fmoc-Ser(But ) (M.W. 383.44)

5g 25 g

[35661-40-6]

2316

(M.W. 337.37)

2,000 8,000

[71989-28-1]

2315

　 (M.W. 387.43)

5g 25 g

[68858-20-8]

– 294 –

Fmoc-D-Amino Acids [1] L.A. Carpino and G.Y. Han, J. Org. Chem., 37, 3404 (1972). [2] L.A. Carpino, Acc. Chem. Res., 20, 401 (1987). [3] G. Barany, N. Kneib-Cordonier, and D.G. Mullen, Int. J. Pept. Protein Res., 30, 705 (1987).

The purity grade of the following products is guaranteed as described in our Purity Criteria on page III (XV). Code

Compound

Price:Yen

2401

Fmoc-D-Ala • H2O

2～10

9-Fluorenylmethoxycarbonyl-D-alanine monohydrate

　 (M.W. 311.33•18.02)

C18H17NO4 • H2O

[79990-15-1]

2421

Fmoc-D-Arg(Pbf)

2～10

N-9-Fluorenylmethoxycarbonyl-N g-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-D-arginine (M.W. 648.77)

C34H40N4O7S

2403 2～10

9-Fluorenylmethoxycarbonyl-D-asparagine C19H18N2O5

[108321-39-7]

2422

Fmoc-D-Asn(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N ω-trityl-D-asparagine (M.W. 596.67)

C38H32N2O5

[180570-71-2]

2～10

9-Fluorenylmethoxycarbonyl-D-aspartic acid β-t-butyl ester C23H25NO6

[112883-39-3]

2405

Fmoc-D-Cys(Trt)

2～10

9-Fluorenylmethoxycarbonyl-S-trityl-D-cysteine

　 (M.W. 585.71)

C37H31NO4S

[167015-11-4]

2406

Fmoc-D-Gln

2～10

9-Fluorenylmethoxycarbonyl-D-glutamine

　 (M.W. 368.38)

C20H20N2O5

[112898-00-7]

2423

Fmoc-D-Gln(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N ω-trityl-D-glutamine (M.W. 610.70)

2407 2～10

C39H34N2O5

[200623-62-7]

　 Fmoc-D-Glu(OBut ) • H2O 9-Fluorenylmethoxycarbonyl-D-glutamic acid γ-t-butyl ester monohydrate

　 (M.W. 425.47 • 18.02)

1g 5g 25 g

7,500 30,000 120,000

1g 5g 25 g

3,700 13,000 52,000

1g 5g 25g

7,500 30,000 120,000

1g 5g 25 g

7,000 25,000 100,000

1g 5g 25 g

7,500 30,000 120,000

1g 5g 25 g

6,000 24,000 110,000

1g 5g 25 g

9,000 36,000 144,000

1g 5g 25 g

7,000 25,000 100,000

C24H27NO6 • H2O

[104091-08-9]

– 295 –


2404

　 Fmoc-D-Asp(OBut ) 　 (M.W. 411.45)

2,300 7,000 30,000

[187618-60-6]

　 Fmoc-D-Asn 　 (M.W. 354.36)

1g 5g 25 g

Fmoc-D-Amino Acids (continued) Code

Compound

Price:Yen

2408

Fmoc-D-His(Trt)

2～10

N α-9-Fluorenylmethoxycarbonyl-N τ-trityl-D-histidine [135610-90-1]

1g 5g 25 g

8,000 30,000 120,000

2420

D-Ile Fmoc　

2～10

9-Fluorenylmethoxycarbonyl-D-isoleucine

1g 5g

25,000 100,000

1g 5g 25 g

4,000 16,000 64,000

1g 5g 25 g

8,000 32,000 140,000

1g 5g 25 g

3,800 15,000 60,000

1g 5g 25 g

3,500 14,000 56,000

1g 5g 25 g

3,800 15,000 60,000

1g 5g 25 g

7,000 25,000 100,000

1g 5g 25 g

7,000 25,000 100,000

1g 5g 25 g

3,000 10,500 45,000

1g 5g 25 g

7,500 30,000 120,000

1g 5g 25 g

8,500 38,000 172,000

1g 5g 25 g

3,000 10,500 45,000

(M.W. 619.71)

(M.W. 353.41)

C40H33N3O4

C21H23NO4

[143688-83-9]

2410

　 Fmoc-D-Leu

2～10

9-Fluorenylmethoxycarbonyl-D-leucine (M.W. 353.41)

C21H23NO4

[114360-54-2]

2411

D-Lys(Boc) Fmoc　

2～10

N α-9-Fluorenylmethoxycarbonyl-N ε-t-butyloxycarbonyl-D-lysine

　 (M.W. 468.54)

C26H32N2O6

[92122-45-7]

2412

Fmoc-D-Met

2～10

9-Fluorenylmethoxycarbonyl-D-methionine

　 (M.W. 371.45)

C20H21NO4S

[112883-40-6]

2413

Fmoc-D-Phe

2～10

9-Fluorenylmethoxycarbonyl-D-phenylalanine

　 (M.W. 387.43)

C24H21NO4

[86123-10-6]

2414

Fmoc-D-Pro

2～10

9-Fluorenylmethoxycarbonyl-D-proline

　 (M.W. 337.37)

C20H19NO4

[101555-62-8]

2415

Fmoc-D-Ser(But )

2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-D-serine

　 (M.W. 383.44)

C22H25NO5

[128107-47-1]

2416

Fmoc-D-Thr(But )

2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-D-threonine

　 (M.W. 397.46)

C23H27NO5

[138797-71-4]

2417

Fmoc-D-Trp

2～10

Nα-Fluorenylmethoxycarbonyl-D-tryptophan (M.W. 426.46) C26H22N2O4 Purity: higher than 97%

[86123-11-7]

2424

Fmoc-D-Trp(Boc)

2～10

N α-9-Fluorenylmethoxycarbonyl-N in-t-butyloxycarbonyl-D-tryptophan (M.W. 526.58)

C31H30N2O6

[163619-04-3]

2418

　 Fmoc-D-Tyr(But )

2～10

9-Fluorenylmethoxycarbonyl-O-t-butyl-D-tyrosine

　 (M.W. 459.53)

C28H29NO5

[118488-18-9]

2419

Fmoc-D-Val

2～10

9-Fluorenylmethoxycarbonyl-D-valine

　 (M.W. 339.39)

C20H21NO4

[84624-17-9]

– 296 –

L-Amino

Acids for Peptide Synthesis

Each of these products will give a mono-spot when 50 µg is subjected to TLC. The content of D-amino acid is guaranteed to be less than 0.1 % except in the case of L-Ser. Code

Compound

2701

L-Alanine 　 (M.W. 89.09)

RT

2702 RT

2703 RT

2704 RT

2705

2706 RT

2708 RT

2707 RT

2709 RT

2710 RT

2711 RT

2712 RT

C3H7NO2

L-Arginine • HCl 　 (M.W. 174.20 • 36.46)

L-Asparagine

[56-41-7]

C6H14N4O2 • HCl

[1119-34-2]

C4H8N2O3 • H2O

[5794-13-8]

• H2 O

(M.W. 132.12 • 18.02)

L-Aspartic Acid 　　 (M.W. 133.10) C4H7NO4

[56-84-8]

L-Cysteine • HCl • H2O 　 (M.W. 121.16 • 36.46 • 18.02)

L-Cystine 　 (M.W. 240.30)

C6H12N2O4S2

L-Glutamic Acid 　 (M.W. 147.13) C5H9NO4

L-Glutamine 　 (M.W. 146.14)

Glycine 　 (M.W. 75.07)

C5H10N2O3

C2H5NO2

L-Isoleucine 　 (M.W. 131.17)

C6H13NO2

[7048-04-6]

[56-89-3]

[56-86-0]

[56-85-9]

[56-40-6]

L-Histidine • HCl • H2O 　 (M.W. 155.15 • 36.46 • 18.02)

L-Hydroxyproline 　 (M.W. 131.13) C5H9NO3

C3H7NO2S • HCl • H2O

C6H9N3O2 • HCl • H2O

[51-35-4]

[73-32-5]

– 297 –

[5934-29-2]

25 g 100 g 500 g

2,200 4,000 11,000

100 g 500 g

3,000 8,000

25 g 100 g 500 g

3,000 6,000 21,000

100 g 500 g

2,100 4,500

100 g 500 g

4,500 13,000

100 g 500 g

4,000 12,000

100 g 500 g

2,100 4,500

100 g 500 g

3,500 9,500

100 g 500 g

2,000 3,000

100 g 500 g

4,500 14,000

25 g 100 g 500 g

6,800 18,000 68,000

25 g 100 g 500 g

3,500 8,000 27,000


RT

Price:Yen

L-Amino Code 2713 RT

2714 RT

2715 RT

2716 RT

2717 RT

2718 RT

2719 RT

2720 RT

2721 RT

2722 RT

2723 RT

Acids for Peptide Synthesis (continued)

Compound

Price:Yen 25 g 100 g 500 g

2,500 4,500 14,000

100 g 500 g

2,100 4,500

100 g 500 g

6,000 20,000

25 g 100 g 500 g

3,000 6,000 21,000

[63-91-2]

25 g 100 g 500 g

2,400 4,500 13,000

[147-85-3]

25 g 100 g 500 g

2,500 4,500 14,000

25 g 100 g 500 g

3,100 6,300 23,000

25 g 100 g 500 g

3,100 6,300 23,000

25 g 100 g 500 g

3,100 6,300 23,000

L-Leucine

(M.W. 131.17)

C6H13NO2

L-Lysine • HCl 　　 (M.W. 146.19 • 36.46)

C6H14N2O2 • HCl

L-Methionine 　 (M.W. 149.21) C5H11NO2S

L-Ornithine

[61-90-5]

[657-27-2]

[63-68-3]

• HCl

(M.W. 132.16 • 36.46)

C5H12N2O2 • HCl

　 L-Phenylalanine 　 (M.W. 165.19) C9H11NO2

L-Proline 　 (M.W. 115.13)

C5H9NO2

[3184-13-2]

L-Serine

(M.W. 105.09)

C3H7NO3 [56-45-1] D-Ser Contamination: less than 2%

L-Threonine 　 (M.W. 119.12)

C4H9NO3

[72-19-5]

L-Tryptophan

(M.W. 204.23)

C11H12N2O2

L-Tyrosine 　　 (M.W. 181.19)

C9H11NO3

[60-18-4]

100 g 500 g

6,000 20,000

L-Valine 　 (M.W. 117.15)

C5H11NO2

[72-18-4]

100 g 500 g

4,200 12,800

[73-22-3]

– 298 –

D-Amino

Acids for Peptide Synthesis

Each of these products will give a mono-spot when 50 µg is subjected to TLC. The amount of L-amino acid in each compound is determined in our laboratory, and the data are provided to customers with each shipment. Code

Compound

2801

D-Alanine 　 (M.W. 89.09)

RT

2802 RT

2815 RT

2814 RT

2817 RT

RT

2805 RT

2819 RT

2806 RT

2813 RT

2807 RT

2808 RT

2816 RT

2818 RT

5g 25 g

2,500 6,000

5g 25 g

7,000 21,000

5g 25 g

5,300 13,000

5g 25 g

3,000 6,000

5g 25 g

6,000 15,000

[6893-26-1]

5g 25 g

2,500 5,000

C6H9N3O2

[351-50-8]

5g 25 g

6,000 15,000

D-Isoleucine 　 (M.W. 131.17) C6H13NO2

[319-78-8]

1g 5g

21,500 100,000

[328-38-1]

5g 25 g

4,000 9,000

5g 25 g

4,500 10,000

5g 25 g

4,000 10,000

5g 25 g

3,500 7,000

D-Arginine 　 (M.W. 174.20)

C3H7NO2

[338-69-2]

C6H14N4O2

[157-06-2]

D-Asparagine • H2O 　 (M.W. 132.12 • 18.02) C4H8N2O3 • H2O

D-Aspartic Acid 　 (M.W. 133.10) C4H7NO4

[1783-96-6]

D-Cysteine • HCl • H2O 　 (M.W. 121.16 • 36.46 • 18.02)

D-Glutamic Acid 　 (M.W. 147.13) C5H9NO4

D-Histidine 　 (M.W. 155.15)

[5794-24-1]

C3H7NO2S • HCl • H2O

D-Leucine

(M.W. 131.17)

C6H13NO2

　 D-Lysine • HCl 　 (M.W. 146.19 • 36.46)

C6H14N2O2 • HCl

D-Methionine 　 (M.W. 149.21) C5H11NO2S

D-Phenylalanine 　 (M.W. 165.19) C9H11NO2

D-Proline 　 (M.W. 115.13)

[7274-88-6]

[348-67-4]

[673-06-3]

C5H9NO2

[344-25-2]

5g 25 g

8,000 20,000

C3H7NO3

[312-84-5]

5g 25 g

4,000 10,000

D-Serine

(M.W. 105.09)

[32443-99-5]

　

– 299 –


2804

Price:Yen

D-Amino

Acids for Peptide Synthesis (continued)

Code

Compound

2809

D-Threonine 　 (M.W. 119.12) C4H9NO3

RT

2810 RT

2812 RT

2811 RT

Price:Yen

D-Tryptophan 　 (M.W. 204.23) C11H12N2O2

[632-20-2]

[153-94-6]

5g 25 g

10,500 28,000

5g 25 g

3,500 7,500

D-Tyrosine 　 (M.W. 181.19)

C9H11NO3

[556-02-5]

5g 25 g

4,500 10,000

D-Valine 　 (M.W. 117.15)

C5H11NO2

[640-68-6]

5g 25 g

3,000 6,000

– 300 –

Amino Acid Derivatives and Esters The purity grade of the following products is guaranteed according to our Purity Criteria on page III (XV). Code

Compound

Grade

2005

Arg(NO2)

2～10

N g-Nitro-L-arginine (N ω-Nitro-L-arginine)

AA

(M.W. 219.20)

C6H13N5O4

Price:Yen 5g 25 g 100 g

2,000 4,000 12,000

[2149-70-4]

　 Nitric Oxide Synthase Inhibitor 1) Y.Kobayashi and K.Hattori, Jpn. J. Pharmacol., 52, 167 (1990). 2) A. Gibson, S. Mirzazadeh, A.J. Hobbs, and P.K. Moore, Br. J. Pharmacol., 99, 602 (1990).

2048

Arg(NO2)-OBzl • Tos

2～10

N g-Nitro-L-arginine benzyl ester monotosylate (M.W. 309.32 • 172.20)

B C13H19N5O4 • C7H8O3S

2045

Asp(OBzl)-OBzl • Tos 　

2～10

L-Aspartic

3,500 11,000 33,000

A

5g 25 g 100 g

2,500 6,000 18,000

A

5g 25 g 100 g

2,600 6,400 19,800

A

5g 25 g 100 g

2,500 6,000 18,000

A

5g 25 g 100 g

2,500 6,000 18,000

A

5g 25 g 100 g

3,000 7,000 20,000

A

5g 25 g 100 g

3,000 7,000 20,000

A

5g 25 g 100 g

3,000 7,000 20,000

B

5g 25 g 100 g

4,500 13,000 40,000

[10342-07-1]

acid α,β-dibenzyl ester monotosylate

　 (M.W. 313.35 • 172.20)

2003

Glu(OBzl)

2～10

L-Glutamic

C18H19NO4 • C7H8O3S

[2886-33-1]

acid γ-benzyl ester

　 (M.W. 237.25)

C12H15NO4

2046

Glu(OBzl)-OBzl • Tos

2～10

L-Glutamic

[1676-73-9]

acid α,γ-dibenzyl ester monotosylate

　 (M.W. 327.37 • 172.20)


2047

Gly-OBzl • Tos

2～10

Glycine benzyl ester monotosylate (M.W. 165.19 • 172.20)

2111

Ile-OBzl • Tos 　

2～10

L-Isoleucine


[2791-84-6]

[1738-76-7]

benzyl ester monotosylate

　 (M.W. 221.30 • 172.20)

2112

Leu-OBzl • Tos

2～10

L-Leucine


[16652-75-8]


(M.W. 221.30 • 172.20)

2110

　 Phe-OBzl • Tos

2～10

L-Phenylalanine


[1738-77-8]


　 (M.W. 255.31 • 172.20)

2049

Pro-OBzl • HCl

2～10

L-Proline


[1738-78-9]

benzyl ester monohydrochloride

(M.W. 205.25 • 36.46)

C12H15NO2 • HCl

[16652-71-4]

　

– 301 –


5g 25 g 100 g

– 302 –