Dec 15, 2008 ... Myasthenia Gravis (MG) is an autoimmune disease characterized by weakness
and ... represent one end of the spectrum of myasthenia gravis.
Correspondence: Robert M. Pascuzzi, MD. Department of Neurology. Emerson Hall 125. 545 Barnhill Drive. Indiana University School of Medicine. Indianapolis ...
Correspondence: Robert M. Pascuzzi, MD. Department of Neurology. Emerson Hall 125. 545 Barnhill Drive. Indiana University School of Medicine. Indianapolis ...
(A Reference for Health Care Professionals) .... data). Participants in a study by Lehky et al. all developed abnromal repetitive nerve ... significant.46 Patients given Mg++ immediately upon recovery from vecuronium block or one hour later.
sessment of myasthenia gravis and the interplay between thymoma and ... complications reported in the study included anti- .... Randomized Trial of Thymec-.
RESUMO â Avaliamos 41 pacientes com miastenia grave timomatosa sob os aspectos epidemiológico, clÃnico e ... mais de 40 anos de idade. ... 7. Arq Neuropsiquiatr 1999;57(1). At the Hospital das Clinicas (General Hospital) of the ...
a positive result in more than 80% of cases. ... Acquired myasthenia gravis (MG) is an immunological disease with antibody activity against the acetylcholine nicotine receptor (antiAChR) of the neuromuscular junction, with fluctuant weakness.
Immediatly before anesthesia was induced, the face mask was removed. The fresh gas flow of the anesthesia machine was adjusted 4. L/min (N2O/O2 70%) and ...
Antibodies are thought to inhibit the function of the post-synaptic ace- tylcholine receptor either by binding to the acetylcholine recognition site ... went trans-sternal thymectomy for myasthenia gravis ... Positive response to edrophonium. 12.
age in those who had the associ- ated myasthenic syndrome. ⡠Key words myasthenia gravis ·. Lambert-Eaton myasthenic syndrome · thymoma · small cell.
Keywords: myasthenia gravis; seronegative MG; AChR antibodies; IgG subclasses; complement .... three with Lambert Eaton myasthenic syndrome, two with.
MYASTHENIA GRAVIS is a disease that presents clinically ... The test for every action of every physician, of ... acetylcholine receptor antibody, are also cross-.
well as in patients with MS, MG, and Graves disease. ... The 10 patients with Graves disease came from ..... We thank Corey Levenson, Dragan Spasic, and Lauri.
Jul 13, 2017 - Late onset: F = M. Tissue pathology. Damage of the thyroid gland. Enlarged thyroid (diffuse goiter). Thymic pathologies, hyperplasia among the ...
be used to make specific decisions. Since each patient's situation is unique and the types of thymectomy being performed
Sep 19, 1988 - An Autoantigenic Site of the Acetylcholine Receptor a-Subunit That Has Biologic Activity ... thetic peptides to identify antibodies in sera of myasthenia .... Positive binding of MG sera was defined as a value greater than the.
Apr 25, 2012 - after onset of myasthenia gravis using the UK General. Practice Research .... Lambert–Eaton type myasthenic syndrome, which mimics. MG.
Autoantibodies to acetylcholine receptor (AChR) are not detectable in approximately 15% of patients with generalized myasthenia gravis. (MG). Antibodies to ...
Thymectomy was performed in 42.6% (n=52) of myasthenic patients. A thymoma was present in 10 patients. Serum ... Key words: myasthenia gravis, clinical evaluation, epidemiology. Miastenia gravis ... The aim of the present study was to explore the cli
Acetylcholine Receptor-induced Clinical Experimental. Autoimmune ... Experimental autoimmune myasthenia gravis (EAMG) is an animal model of human myasthe- nia gravis (MG). ... AChlL antibody levels compared with those in the WT mice. Comparatively ..
122 pacientes: 85 (69,7%) do sexo feminino e 37 (30,3%) do sexo ... de doença variou de 5 meses a 50 anos (8,9±8,1 anos). A idade de inicio da doença.
Two included randomized clinical trials showed superiority of the surgical treatment over the ... Keywords: Myasthenia gravis, Thymectomy, Drug therapy.
in dorsal feet interosseous and anterior tibial, and decreased deep tendon reflexes. Repetitive nerve stimulation of the ulnar and fibular nerves showed a ...
Acquired autoimmune myasthenia gravis (MG) is the most prevalent myasthenia type, and .... Randomized trial of thymectomy in myasthenia gravis. N Engl J ...
CANADIAN JOURNAL OF ANAESTHESIA ume teaching unit, on a regular basis, in order to maintain their expertise and to learn new techniques. The second ...
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ume teaching unit, on a regular basis, in order to maintain their expertise and to learn new techniques. The second concern relates to the management of potential complications when an anaesthetist may not be physically present. This concern also relates to higher volume units where the anaesthetist may be "tied up" in an operating room with a surgical case. In fact the guidelines actually contain the answer in that they state that "an appropriate protocol for the management of these epidurals is in place. ''1 I would suggest that the setting up of these protocols is the most important aspect of this document. It is essential that the nurses caring for these parturients be educated in the recognition of complications and their initial management. This education, in the low-volume units, must not be a one-time event. It should be repeated and reemphasized at regular intervals. Additionally, other physicians who might be physically present in the hospital should be educated and trained in the management of these complications. This would include obstetricians, family and emergency physicians. The other recommendation is that all hospitals practicing obstetrics should have a regular program of CPR training with emphasis on the parturient. 3 The importance of uterine displacement in critical situations may not be recognized unless specifically included in the protocols. The normal response to finding a hypotensive, apnoeic patient is to place him/her supine in the Trendelenburg position. This could prove fatal in the parturient. M. Joanne Douglas MD
Division of Obstetric Anaesthesia Grace Hospital Vancouver, B.C. V6H 3V5 REFERENCES 1 Appendix IV Epidural analgesia during childbirth. In: Guidelines to the Practice of Anaesthesia as Recommended by the Canadian Anaesthetists' Society. Revised Edition. 2 Palahniuk RJ. Obstetrical epidural anaesthesia in remote hospitals (Editorial). Can J Anaesth 1988: 35: 488-50. 3 Rees GAD, Willis BA. Resuscitation in late pregnancy. Anaesthesia 1988; 43: 347-9.
Anaesthesia and myasthenia
gravis To the Editor: I was disappointed that the comprehensive review article by Baraka I made little or no mention of the benefits of
C A N A D I A N J O U R N A L OF A N A E S T H E S I A
combined regional/general anaesthesia in these patients. Although Dr. Baraka pointed out that the use of regional or local anaesthesia "seems warranted in these patients," he did not expand on this concept when discussing the management of retrosternal thymectomy. A thoracic or high lumbar epidural anaesthetic in combination with balanced general anaesthesia provides excellent analgesia both intraoperatively and during the period following the thymectomy.2 This decreases the stress response to the sternotomy, decreases opioid requirements and perhaps even the dose of neuromuscular blocking agents. This in turn allows these patients to meet extubation criteria earlier and in some individuals prevents the need for postoperative ventilation. The current trend for anaesthetists to emphasize aggressive pain management, 3 not only for aesthetic reasons, has seemed to miss a beat in this article. I hope this letter may perhaps remind readers of the obvious benefits of a combined regional/general anaesthetic technique, using an indwelling epidural catheter for retrosternal thymectomy. David R. Gambling MB DRCOGFRCPC Vancouver, B.C. REFERENCES 1 Baraka A. Anaesthesia and myasthenia gravis. Can J
lumbar epidural morphine improves postoperative analgesia and ventilatory function after transsternal thymectomy in patients with myasthenia gravis. Crit Care Med 1991; 19: 1474-9. 3 Commission on the Provision of Surgical Services. Report of the Working Party on Pain after Surgery. The Royal College of Surgeons of England and College of Anaesthetists. September 1990. REPLY Thank you for referring to me the letter o f Dr. Gambling. 1 agree
with him that thoracic or simply high lumbar epidural analgesia using local anaesthetic and~or narcotic, in combination with a balanced general anaesthesia, provides excellent analgesia both intraoperatively and postoperatively. The benefits of this combination are not limited to myasthenic patients undergoing thymectomy t but also apply to other patients undergoing any thoracic; or major abdominal and vascular surgery. 3However, the concept is still controversial. 4 Many of our patients do not accept the idea of having a needle or a catheter in their "back" as a modality for pain relief. Also, because o f the possible delayed respiratory depression, all patients having epidural morphine must be observed in an ICU setup for at least 12-24 hr postoperatively.
Anis Baraka FRCAnaesth(Hon) American University of Beirut Beirut - Lebanon