Antenatal and postnatal combined therapy for ... - BioMedSearch
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Antenatal and postnatal combined therapy for ... - BioMedSearch
Nov 29, 2013 - In cases of 3rd degree CHB often pacemaker implantation is needed. Keyword: Autoantibody-associated congenital heart block, Combination ...
Di Mauro et al. BMC Pregnancy and Childbirth 2013, 13:220 http://www.biomedcentral.com/1471-2393/13/220
CASE REPORT
Open Access
Antenatal and postnatal combined therapy for autoantibody-related congenital atrioventricular block Antonio Di Mauro1*, Vita Caroli Casavola2, Giovanna Favia Guarnieri1, Grazia Calderoni1, Ettore Cicinelli2 and Nicola Laforgia1
Abstract Background: Autoantibody-related congenital heart block (CHB) is an autoimmune condition in which trans placental passage of maternal autoantibodies cause damage to the developing heart conduction system of the foetus. Case presentation: We report a case of an Italian 31–year-old woman, in a good clinical status, referred to our Centre at 26 weeks of her first pregnancy, because of foetal bradycardia, found during routine foetal ultrasonography. Foetal echocardiography revealed a 3rd degree CHB, without any anatomical defects. Despite the mother was asymptomatic for autoimmune disease, anti-Ro/La were searched for, because of the hypothesis of autoantibody-related CHB. High title of maternal anti-Ro/SSA antibodies was found and diagnosis of an autoantibody-related CHB was made. A combination treatment protocol of the mother was started with oral betamethasone, plasmapheresis and IVIG. An emergency C-section was performed at 32 + 3 weeks of gestation because of a non-reassuring cardiotocography pattern. A male newborn (BW 1515 g, NGA, Apgar 8–10) was treated since birth with high-flow O2 for mild RDS. IVIG administration was started at one week, and then every two weeks, until complete disappearance of maternal antibodies from blood. Because of persistent low ventricular rate (
