and ceruloplasmin), antioxidant molecules (reduced glutathione), antioxidant enzymes (glutathione peroxidase and superoxide dismutase), antioxidant vitamins ...
Indian Journal of Clinical Biochemistry, 2007 / 22 (1) 45-51
ANTIOXIDANT STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Neela Patil, Vishwas Chavan, N.D.Karnik* Department of Biochemistry and *Department of Medicine, L.T.M.Medical College and General Hospital, Mumbai 400022, India. ABSTRACT Free radicals play an important role in the pathogenesis of tissue damage in many clinical disorders, including atherosclerosis. Antioxidants protect the body from damage caused by free radicals. In this study we investigated oxidative stress, antioxidants and inflammatory molecules in patients with acute myocardial infarction. This study has been carried out on 106 patients with acute myocardial infarction, (89 men and 17 females). The control group consisted of 50 healthy, age-matched subjects (40 men and 10 females). Levels of Glucose, lipid profile, glutathione reduced, glutathione peroxidase, Superoxide dismutase, Glycosylated hemoglobin, fibrinogen, vitamin C, vitamin E, malondialdehyde, ceruloplasmin, adenosine deaminase, lysozyme and sialic acid were measured. Malondialdehyde and ceruloplasmin levels were significantly high and antioxidants such as vitamin C, vitamin E, glutathione reduced, glutathione peroxidase and superoxide dismutase were significantly decreased in diabetic and non-diabetic AMI patients as compared with control (p
