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Apr 24, 2008 - Abstract Trichomoniasis, caused by the protozoan parasite. Trichomonas vaginalis, is a major nonviral sexually transmitted disease. Clinical ...
Parasitol Res (2008) 103:305–312 DOI 10.1007/s00436-008-0971-y

ORIGINAL PAPER

Antitrichomonas IgG, IgM, IgA, and IgG subclass responses in human intravaginal trichomoniasis Simernjeet Kaur & Sumeeta Khurana & Rashmi Bagga & Ajay Wanchu & Nancy Malla

Received: 10 October 2007 / Accepted: 24 March 2008 / Published online: 24 April 2008 # Springer-Verlag 2008

Abstract Trichomoniasis, caused by the protozoan parasite Trichomonas vaginalis, is a major nonviral sexually transmitted disease. Clinical spectrum varies from an asymptomatic state to mild, moderate, or severe symptoms. However, the exact factors leading to the variations in symptoms have not been well elucidated. Host’s immune response to the parasite may be playing a role in varied symptomatology. The present study reports antitrichomonas IgM, IgA, IgG and its subclasses in doubling dilutions of serum and diluted vaginal washes of six T. vaginalisinfected symptomatic and four T. vaginalis-infected asymptomatic women and uninfected controls by enzyme-linked immunosorbent assay (ELISA). No significant difference was observed in serum IgG ELISA absorbance values from symptomatic compared to asymptomatic subjects (p>0.05) while a significant difference (p