American Society for Investigative Pathology
American Society for Nutrition
American Society for Pharmacology and Experimental Therapeutics
TRANSFORMING THE FUTURE THROUGH SCIENCE
CHICAGO
APRIL 22-26 PROGRAM
2017
EXPERIMENTAL BIOLOGY 2017 Transforming the Future through Science McCormick Place Convention Center April 22–26, 2017 AN ANNUAL MEETING OF PROFESSIONAL RESEARCH SCIENTISTS HOST SOCIETIES
American Association of Anatomists (AAA) The American Physiological Society (APS) American Society for Biochemistry and Molecular Biology (ASBMB) American Society for Investigative Pathology (ASIP) American Society for Nutrition (ASN) American Society for Pharmacology and Experimental Therapeutics (ASPET)
GUEST SOCIETIES American College of Pediatrics (ACP) American Society of Animal Science (ASAS) Chinese Society for Anatomical Sciences (CSAS) Association of Nutrition Departments and Programs (ANDP) Society for Vertebrate Paleontology (SVP) Brazilian Society for Food and Nutrition (BSFN) Canadian Nutrition Society (CNS-SCN) APS Chinese Nutrition Society (CNS) American College of Sports Medicine (ACSM) Collegiate and Professional Sports Dietitians American Federation for Medical Research (AFMR) Association (CPSDA) Brazilian Society of Physiology (SBFiS) Friedman Fellows Biomedical Engineering Society (BMES) ILSI North America (ILSI) Microcirculatory Society (MCS) Institute of Food Technologists (IFT) The Physiological Society (PhySoc) International Colleges for the Advancement of Nutrology (ICAN) International Society for Research in Human ASBMB Milk and Lactation (ISRHML) Biochemical Society Japan Society of Nutrition and Food Science (JSNFS) Division of Biological Chemistry–American Chemical Society (ACS) Korean Nutrition Society (KNS) Panamerican Association for Biochemistry and Molecular National Board of Physician Nutrition Specialists (NBPNS) Biology (PABMB) North American Society for Pediatric Gastroenterology, RNA Society (RNA) Hepatology and Nutrition (NASPGHAN) Society for Experimental Biology and Medicine (SEBM) Nutrition Society of Taiwan (NST) Plant Phenolics and Human Health Research Interest Group ASIP (PhenHRIG) American Society for Matrix Biology (ASMB) Society for Nutrition Education and Behavior (SNEB) American College of Veterinary Pathologists (ACVP) Society for Pediatric Research (SPR) Association of Pathology Chairs (APC) Southern Society for Clinical Investigation (SSCI) American Physician Scientists Association (APSA) The Nutrition Society UK (NSUK) The Histochemical Society (HCS) Vitamin Society of Japan (VJS) The Society for Cardiovascular Pathology (SCVP) Società Italiana di Patologia e Medicina Traslazionale/Italian ASPET Society of Pathology and Translational Medicine (SIPMeT) Behavioral Pharmacology Society (BPS) Society of Toxicologic Pathology (STP) Global GI Club (GGC) Japanese Pharmacological Society (JPS) ASN
AAA
Academy of Nutrition and Dietetics (AND) African Graduate Nutrition Students Network (AGSNET) American Academy of Pediatrics (AAP)
Experimental Biology Management Office 9650 Rockville Pike, Bethesda, MD 20814 Phone: 301-634-7010; Fax: 301-634-7014; Email:
[email protected] Web: www.experimentalbiology.org Copyright © 2010 by the Federation of American Societies for Experimental Biology
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TABLE OF CONTENTS 2017 Host and Guest Societies............................................i Host Society Officers......................................................... iii 2017 EB Committees......................................................... iv Office * Locations * Hours * Telephone Numbers...........v Code of Conduct................................................................ vi General Information........................................................ vii Registration........................................................................ vii Society Ticketed Events.................................................... viii Attire/Dress Code................................................................ ix Badge Pick-Up.................................................................... ix Certificate of Attendance..................................................... ix Coat Check/Luggage Storage............................................. ix Conference Photo Consent.................................................. ix Drinking Policy................................................................... ix EB17 App............................................................................ ix EB2018—San Diego........................................................... ix E-Posters and Poster Pick-Up............................................. ix Online Poster Access.............................................................x Exhibits.................................................................................x Product Workshops and Exhibitor Showcases......................x Family Room and Nursing Lounge.......................................x First Aid................................................................................x Food And Beverage...............................................................x Housing Inquiries..................................................................x Internet Access......................................................................x Wireless Access.....................................................................x Lost and Found.....................................................................x Message Center/Literature Tables.........................................x Poster Presentations And Policy...........................................x Recording............................................................................ xi Restaurant Reservations And City Information.................. xi Speaker Information and Speaker Preview Rooms............ xi Special Needs..................................................................... xii Transportation.................................................................... xii Ground Transportation....................................................... xii Young Experimental Scientists (Y.E.S.) Mixer.................. xii
Diagrams McCormick Place Convention Center.............................. xiii Hyatt Regency McCormick Place.................................... xvii Hilton Chicago.................................................................. xix EB-Sponsored Special Programs NIH Grant Seminar Workshop Series..................... xxii NIH Career Development (K) Awards...................xxii NIH Fellowship (F) Awards............................................. xxii Career Development Seminars & Workshops................ xxiii Oral Sessions by Day/Society Friday, April 21.....................................................................1 Saturday, April 22.................................................................3 Sunday, April 23..................................................................37 Monday, April 24................................................................82 Tuesday, April 25..............................................................120 Wednesday, April 26.........................................................169 Poster Sessions by Day/Society Sunday, April 23................................................................185 Monday, April 24..............................................................282 Tuesday, April 25..............................................................381 Wednesday, April 26.........................................................477 Exhibits General Information..........................................................493 Floor Plan..........................................................................494 Company Index.................................................................496 Government Exhibits........................................................529 Product Index....................................................................530 Books, Journals, Publications........................................533 Exhibitor Workshops......................................................551 Exhibitor Showcases.......................................................552 Indexes Author/Speaker Index.......................................................553
HOST SOCIETY OFFICERS
K. Topp, President P. Brauer, President-Elect L. Opperman, President Emeritus V. DeLeon, Secretary-Treasurer P. Trainor, Program Co-chair M. Dunnwald, Program Co-chair S. Boynes, Executive Director
J. Reckelhoff, President P. Molina, Past President D. Brown, President-Elect M. Frank, Executive Director R. Hester, Joint Program Committee Chair
N. Ahn, President and Program Co-Chair S. McKnight, Past President and Program Co-Chair T. M. Antalis, Treasurer J. DuBois, Secretary B. A. Gordon, Executive Director
G.K. Michalopoulos, President W.B. Coleman, Past President D.G. Remick, President-Elect A. Nusrat, Vice President S.P. Monga, Secretary-Treasurer R.N. Mitchell, Program Committee Chair M. E. Sobel, Executive Officer
M. L. Neuhouser, President M. A. Johnson, Vice President C. J. Field, Vice-President Elect P. M. Coates, Treasurer S. Percival, Secretary R. M. Russell, Foundation Chair J. E. Courtney, Executive Officer S. K. Fried, Program Chair
D.R. Sibley, President J.D. Schuetz, President-Elect K.E. Thummel, Past President C.P. France, Secretary/Treasurer J.A. Siuciak, Executive Officer S.A. Waldman, Program Committee Chair
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2017 EB COMMITTEES
EXPERIMENTAL BIOLOGY BOARD R. Hester, APS, Chair M. Dunnwald, AAA M. B. Furie, ASIP J. Hill, ASN P. F. Hollenberg, ASPET L. Justement, AAI D. Raben, ASBMB
MANAGEMENT COMMITTEE J. Courtney, ASN, Chair S. Boynes, AAA M. Frank, APS B. Gordon, ASBMB J. Siuciak, ASPET M. E. Sobel, ASIP
EXHIBITS ADVISORY COMMITTEE J. Zacka, Chair, Worthington Biochemical Corp B. Archibald, Pro Scientific, Inc. J. Kearney, Exhibits Manager, FASEB OSMC C. Locke, Drummond Scientific O. Padilla, Bio-Rad Laboratories H. Santos, Scientific Industries, Inc. A. Waluszko, UVP/Analytik Jena
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OFFICE * LOCATIONS * HOURS * TELEPHONE NUMBERS AAA McCormick Place, Room W176C Saturday–Tuesday, 7:30 AM–5:30 PM APS ....................................................................... 312-528-8204 Hyatt Regency McCormick Place, Jackson Park A Saturday–Tuesday, 7:00 AM–5:00 PM Wednesday, 7:00 AM–3:00 PM ASBMB ............................................................... 312-949-8601 McCormick Place, Room W185D Sunday- Tuesday, 9:00 AM–4:30 PM Wednesday, 9:00 AM- 12:00 PM ASIP...................................................................... 312-949-8615 McCormick Place, Room W181C Saturday–Tuesday, 8:00 AM–5:00 PM ASN....................................................................... 312-791-6600 McCormick Place, Room S101B Saturday–Tuesday, 7:30 AM–5:30 PM ASPET.................................................................. 312-949-8600 McCormick Place, Room W471B Saturday, 11:00 PM–4:00 PM, Sunday, 7:30 AM–6:00 PM Monday–Tuesday, 7:30 AM–6:30 PM Wednesday, 7:30 AM–4:00 PM
INFORMATION DESK ..................................... 312-528-6778 Hyatt Regency McCormick Place, Boardroom 5 Meeting Management Office Saturday–Wednesday, 8:00 AM–5:00 PM INFORMATION DESK ..................................... 312-294-6621 Hilton Chicago, Room PDR6 Saturday–Wednesday, 8:00 AM–5:00 PM LOST AND FOUND ........................................... 312-949-8604 McCormick Place, Hall F, Registration B Meeting Management Office MEETING MANAGEMENT OFFICE ............ 312-949-8604 McCormick Place, Hall F, Registration B Thursday, 7:30 AM–5:00 PM Friday–Saturday, 7:30 AM–6:00 PM Sunday–Wednesday, 7:30 AM–5:00 PM REGISTRATION .............................................. 312-791-7104 McCormick Place, Hall F, Registration B Friday, 1:00 PM–6:00 PM, Saturday, 7:00 AM–8:00 PM Sunday–Tuesday, 7:00 AM–5:00 PM Wednesday, 7:00 AM–3:00 PM SPECIAL NEEDS/ADA...................................... 888-441-7575 McCormick Place, Hall F, Registration B
AV HEADQUARTER OFFICE ........................ 312-949-8616 McCormick Place, Room 195 Friday–Wednesday, 7:00 AM–6:00 PM
SPEAKER PRACTICE ROOM McCormick Place, Room W182........................... 312-949-8620 Saturday–Wednesday, 7:00 AM–6:00 PM
CAREER RESOURCES Registration Lobby Saturday, 9:00 AM– 5:00 PM
McCormick Place, Room W191........................... 312-949-8621 Saturday–Wednesday, 7:00 AM–6:00 PM
McCormick Place, Hall F2 Sunday–Monday, 9:00 AM–5:00 PM, Tuesday, 9:00 AM–4:00 PM McCormick Place, Skyline Ballroom Wednesday, 9:00 AM–12:00 PM EXHIBIT MANAGEMENT .............................. 312-949-8609 McCormick Place, Hall F Thursday–Tuesday, 8:00 AM–5:00 PM EXHIBITOR REGISTRATION ....................... 312-949-8611 McCormick Place, Hall F, Registration C Friday–Tuesday, 8:00 AM–4:00 PM FIRST AID ........................................................... 312-791-6060 McCormick Place, Transportation Gates 43 and 44, Level 1 Friday–Wednesday, 7:30 AM–6:00 PM
McCormick Place, Room S101A ......................... 312-949-8622 Saturday-Wednesday, 7:00 AM–6:00 PM MCCORMICK PLACE 2301 S. King Drive Chicago, IL 60616 Main #: 312-791-7000 HYATT REGENCY MCCORMICK PLACE 2233 S. Dr. Martin Luther King Jr. Dr. Chicago, IL 60616 Main #: 312-567-1234 HILTON CHICAGO 720 South Michigan Avenue Chicago, IL 60605 Main #: 312-922-4400
EB INFO/HOUSING DESK .............................. 312-949-8612 McCormick Place, Hall F, Registration B Friday, 1:00 PM–6:00 PM, Saturday, 7:00 AM–6:00 PM Sunday 7:00 AM–5:00 PM
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CODE OF CONDUCT Experimental Biology is committed to providing a friendly, safe, and welcoming environment for all, regardless of gender, sexual orientation, disability, race, ethnicity, religion, national origin, or other protected characteristics. We expect all attendees, media, speakers, volunteers, organizers, venue staff, guests, and exhibitors to help us ensure a safe and positive conference experience for everyone.
♦♦Sustained disruption of scientific sessions or other events ♦♦Unwelcome and uninvited attention or contact ♦♦Physical assault (including unwelcome touch or groping) ♦♦Real or implied threat of physical harm
We expect all participants at EB2017 to abide by this ♦♦Real or implied threat of professional or financial damage or harm Code of Conduct in all venues, including ancillary events and all social gatherings. What To Do If You Witness or Experience Conduct ♦♦Exercise consideration and respect in your speech That Violates the Code: and actions. EB and participating Society staff will be happy to help ♦♦Refrain from demeaning, discriminatory, or participants contact convention center/hotel/venue security or local law enforcement, and otherwise assist harassing behavior and speech. those experiencing harassment, to enable them to feel ♦♦Be mindful of your surroundings and of your fellow safe for the duration of the conference. We value your participants. Alert the EB Management Office if you attendance, and want to make your experience as notice a dangerous situation, someone in distress, or productive and professionally stimulating as possible. violations of this Code of Conduct. Please contact the EB Management Office or Unacceptable Behaviors the nearest participating Society office or email
[email protected] to file a Unacceptable Behaviors Include: complaint. All reports will be confidential. ♦♦Intimidating, harassing, abusive, discriminatory, derogatory or demeaning speech or actions by any Consequences of Unacceptable Behavior participant at EB2017 and at all related events Unacceptable behavior from any participant at ♦♦Harmful or prejudicial verbal or written comments or visual images related to gender, sexual orientation, race, religion, disability, or other personal characteristics
EB2017, including attendees, sponsors , exhibitors, contractors, volunteer leaders, vendors, venue staff, and anyone with decision-making authority, will not be tolerated. Anyone asked to stop unacceptable behavior is expected to comply immediately.
♦♦Inappropriate use of nudity and/or sexual images in If a participant engages in unacceptable behavior, public spaces (including presentation slides) Experimental Biology staff may take any action they ♦♦Deliberate intimidation, stalking, or following deem appropriate, including removal from EB2017, without refund, and/or future EB meetings. Egregious ♦♦Harassing photography violations will result in more severe sanctions, ♦♦Photographing slides of oral presentations and including the possibility of reporting to local law posters without the express permission of the enforcement. presenter/author See the Scientific Integrity Policy for more information. ♦♦Recording of scientific and other sessions without the express permission of the participants
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GENERAL INFORMATION REGISTRATION McCormick Place, Hall F, Registration B Hours Friday: 1:00 pm–6:00 pm Saturday: 7:00 am–8:00 pm Sunday–Tuesday: 7:00 am–5:00 pm Wednesday: 7:00 am–3:00 pm Fees Host/Guest Society Member $560 Nonmember $750 Retired Society Member $160 Retired Nonmember $190 *Graduate Student Member $95 *Graduate Student Nonmember $120 **Undergraduate Member/Nonmember $30 ***Postdoctoral Trainee Member $435 ***Postdoctoral Trainee Nonmember $435 1-Day Member $205 1-Day Nonmember $350 ****High School Teachers and High School Students Free
****High School Teachers and High School Students: You must be a certified High School Teacher currently teaching High School students. You do not qualify for this category if you are currently teaching at a University or a Hospital. Credentials or a letter from the school principal will need to be provided on-site to receive your badge. High School Students should bring a student ID card or a letter signed by your teacher to receive your badge. Guest Registration: Spouses and other non-scientist family members who wish to see a family member’s presentation may pick up a guest pass at a participating Society office or the Meeting Management Office. Guest passes allow admittance to a family member’s session but does not include other exhibits, scientific sessions, or social activities.
Cancellation and Refund Policy: The registration receipt and a letter requesting a refund of the registration fee must be received by March 23, 2017. A $50 non-refundable processing fee will be deducted and after March 23, 2017 no refunds *Graduate Student Registration: You must have will be issued. Please mail to: Experimental Biology a department head or research advisor certify your Registration Office 9650 Rockville Pike Bethesda, student eligibility. If registering online, enter the MD 20814-3998 name and email address of your department head. If registering at the meeting, bring your ID card or Exhibitor Registration: a letter signed by your department head. “Student” Company representatives and guests of exhibitors may will be indicated on your badge. Postdoctoral fellows, register at the Exhibitor Registration Desk in Hall F, hospital residents, interns and laboratory technicians Registration B and C on the 2nd level at the McCormick do not qualify as students. Place. Registration will be open Friday–Tuesday. **Undergraduate Students and High School Students: Registration will be accepted in advance. To receive your badge on-site, bring a student ID card or a letter signed by your department head, research advisor or teacher. ***Postdoctoral Trainee: Trainees have obtained their doctoral degree within the last five years and are currently enrolled in a postdoctoral trainee program.
New in 2017! EB Welcome Reception Saturday, April 22, 7:00 pm–8:30 pm Join fellow attendees for our first-ever, interdisciplinary meet and mingle. Appreciate the power and energy of the EB Meeting as all career levels come together for fun and networking. Light refreshments will be served. Member-attendees receive one complimentary drink ticket when they sign up for the event during EB Meeting registration. Cash bar also available.
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SOCIETY TICKETED EVENTS The following special Society activities have been planned and may require a fee in addition to the Experimental Biology 2017 registration fee.
XVIIth Annual ASIP/AAA Career Development and Mentoring Program and Lunch: Developing Your Core Message: An Interactive Session on Crafting an Effective Elevator Speech Sunday, April 23, 2017 at 11:45 am AAA TICKETED EVENT: *ASIP Trainee members and AAA Student Members AAA Closing Awards Ceremony & Reception— will receive a complimentary ticket* Tuesday, April 25 $15 for ASIP/AAA Members Join the American Association of Anatomists at the $30 for Non-Members Closing Awards Ceremony on Tuesday, April 25, 2017. The Awards Ceremony is from 7:00 pm to 10:00 pm at Scientific Interest Group Networking Sessions the Hilton Chicago and will feature a cocktail reception, and Poster Discussions dinner, & presentation of AAA awards. Tickets are Tuesday, April 25, 2017 at 5:30 pm FREE FOR ALL ATTENDEES $85 on-site. APS TICKETED EVENT: APS Closing Party—Wednesday, April 26, 2017 7:00 pm to 10:00 pm in the Hyatt Regency McCormick Place. Tickets are $30 in advance and $40 onsite. The closing party will include live bands GI Distress and the winner of the battle of the band. ADMISSION IS BY TICKET ONLY.
Please sign up for these events when registering for Experimental Biology by checking the boxes on the registration form.
ASN TICKETED EVENTS: ASN on Demand Purchase access to the ASN at Experimental Biology 2017 sessions via ASN on Demand. Slide-synced Please sign up for this event when registering audio or podcasts can be accessed at your convenience for the meeting by checking the boxes on the on your computer or mobile device 24/7. Sessions registration form. offered are subject to permission by the presenter. Advance Purchase: $100 • Post-Meeting: $350 ASBMB TICKETED EVENT: ASBMB Presents a Day of Development for ASN Emerging Leaders Poster Competition Graduate Students and Postdoctoral Fellows Saturday, April 22 at 5:00 pm–7:00 pm McCormick Place Hall F Saturday, April 22nd, 8:30 am–4:30 pm Details at www.asbmb.org/meeting2017 Poster viewing is free of charge. Advance registration Sign up during EB meeting registration (limited space). is advised. $25, ASBMB Members, $35, all other EB registrants ASN Presidential Symposium Events include career panel, workshops, speakers Sunday, April 23 at 8:30 am–10:00 am luncheon and networking. McCormick Place Ballroom S100BC Chair: Marian L. Neuhouser, PhD, President, ASIP TICKETED EVENTS: American Society for Nutrition. Session is free of XVIIth Annual Workshop on Graduate charge. Advance registration is advised. Education in Pathology: PhD Workforce Saturday, April 22, 2017 at 11:45 am ASN Awards Ceremony $15 for ASIP Members Sunday, April 23 at 6:00 pm–7:30 pm $30 for Non-Members McCormick Place Ballroom S100BC Ceremony is free of charge. Advance registration Committee for Career Development & Diversity is advised. Workshop and Breakfast: Developing Your Personal Brand for Career Success Sunday, April 23, 2017, at 7:00 am $10 for ASIP Members $20 for Non-Members
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Fellows, 50-Year Members, and Past Presidents Luncheon Monday, April 24 at 11:30 am–2:00 pm Hilton Chicago Join ASN in celebrating the accomplishments and achievements of our past and present Fellows, 50Year members, and former society presidents over lunch at the annual meeting. This luncheon will include a presentation honoring the newly inducted class of 2017 ASN Fellows. All members are invited to attend; guests are permitted. *All newly inducted Fellows will receive two complimentary tickets. $25 for ASN Members • $50 for Non-Members
COAT CHECK/LUGGAGE STORAGE McCormick Place, Level 1 Gate 44 Luggage storage and coat check will be available Friday through Wednesday. It costs $3 per coat checked and $4 per bag checked. Please do not bring luggage to the meeting rooms. CONFERENCE PHOTO CONSENT Upon registering for Experimental Biology 2017, you affirmed that you agreed to allow official Experimental Biology photographers to record your participation and reproduce your likeness in publications, online, etc.
DRINKING POLICY Alcoholic beverages will be offered at various social ASN Sunrise Boot Camp activities and the Experimental Biology participating Sunday, Monday & Tuesday Mornings Societies, the McCormick Place, the Hyatt Regency 6:30 am–7:30 am McCormick Place, and the Hilton Chicago, encourage Grant Park, Across from Hilton Chicago Join your fellow EB attendees for an early morning responsible drinking. Alcohol will only be served to those over the age of 21 and some participants may workout with ASN. You’ll feel better all day! be required to provide photo identification. Alcoholic Please sign up for these activities when registering for beverages are allowed only in specific areas and must Experimental Biology by checking the boxes on the not be taken out of those immediate areas. registration screen. EB17 APP ATTIRE/DRESS CODE Download the mobile app today to easily search for Attire is business casual. Wear comfortable shoes and sessions, speakers, exhibitors, and connect with your dress in layers. colleagues—all in the palm of your hand. Search for Experimental Biology 2017 in the App store BADGE PICK-UP or navigate to http://m.core-apps.com/eb2017 on Badges were not mailed in advance. There will your device. be on-site kiosks to print badges at the McCormick Place, Hall F Registration B and C on the 2nd level. EB2018—SAN DIEGO Lost or forgotten badges can only be replaced at EB18 will be held in San Diego, CA April 21–25, 2018. the Replacement Badge Counter at the cost of $25. Start planning NOW for your participation at EB18! Program information will ONLY be available online prior to the meeting for individual downloading. You E-POSTERS AND POSTER PICK-UP should also plan to download the meeting app prior McCormick Place, Hall F Mira has arranged for pre-ordering of poster printing to arriving. and delivery to the Experimental Biology 2017 NOTE: Badges must be worn at all times and no meeting. Information was sent in advance with access will be granted to the Exhibit Hall or scientific confirmation information. Posters may be picked up sessions without a badge. Children under the age during registration hours (Friday, 1:00 pm–6:00 pm, of 16 are not required to wear a badge but must be Saturday, 7:00 am–6:00 pm, Sunday–Wednesday, 7:00 am–5:00 pm). Onsite printing will be available accompanied by a registered attendee. using FedEx Kinkos on Level 2 in the West Building. CERTIFICATE OF ATTENDANCE Visit FedEx online to order, or contact FedEx at the Beginning on Monday, April 24, Certificate McCormick Place by calling (312) 949-2100. of attendance can be printed at a kiosk located at the Registration Desk in the McCormick Place, Hall F, Registration B and C.
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ONLINE POSTER ACCESS Following the EB 2017 meeting, all registered attendees will have access to PDFs of the online posters through the e-poster link on the EB 2017 website. All presenters are requested to upload a PDF file of their poster starting on February 21. Only registered attendees will be able to access the e-poster site.
FOOD AND BEVERAGE Concessions will be open in the West Food Court, Saturday–Wednesday. Food service offers continental breakfast, hot foods, sandwiches, salads, light snacks and beverages. A number of concessions throughout the exhibit halls will be open offering a variety of “grab and go” foods.
EXHIBITS McCormick Place, Hall F Exhibits will be open from 9:00 am–4:00 pm, Sunday– Tuesday. See pages 496–550 for complete list of exhibiting companies and products and visit the EB17 app to customize your visit and itinerary. Visit www.experimentalbiology.org and click on Floor plan and Current Exhibitors to organize your booth visits. Admission to the Exhibits is by official badge only. Children under the age of 16 are permitted access to the Exhibit Hall without a badge during show hours but must be accompanied by a registered adult. Children are not permitted in exhibit halls during set up or dismantling hours.
HOUSING INQUIRIES McCormick Place, Hall F, Registration B An Experient housing bureau representative will be located in Hall F, at the Information Kiosk to manage hotel questions and concerns.
PRODUCT WORKSHOPS AND EXHIBITOR SHOWCASES Exhibitor workshops and showcases provide exhibiting companies with opportunities to talk about new product lines and services and offers audience interaction and informal discussion beyond the exhibit hall. Product workshop and showcase descriptions, times and locations are listed on pages 551–552.
LOST AND FOUND Please visit the Meeting Management Office located in Hall F, of the McCormick Place to look for items lost or turned in items found.
FAMILY ROOM AND NURSING LOUNGE McCormick Place, Hall F (See EB Management Office) The family room will be open during registration hours. The area is intended to provide a quiet environment where children can be taken for a break.
INTERNET ACCESS Cyber Café McCormick Place, Hall F, Registration B Internet kiosks will be provided for checking email. WIRELESS ACCESS Complimentary wireless access will be available Friday through Wednesday at both the McCormick Place and the Hyatt Regency McCormick Place.
MESSAGE CENTER/LITERATURE TABLES McCormick Place, Hall F, Registration B The message center and free literature tables will be located in Hall F. Registrants can check for messages and post fliers advertising social events or upcoming meetings. Exhibitors are not permitted to display any materials on the literature tables.
POSTER PRESENTATIONS AND POLICY McCormick Place, Hall F All poster presentations are scheduled in Hall F FIRST AID and the Skyline Ballroom at McCormick place. McCormick Place, Transportation Gates 43 and Late-breaking posters are scheduled in the Skyline 44 on Level 1 Ballroom (Wednesday only). Presenters must hang A First Aid room will be located on the Mezzanine their posters on the appropriate poster board no later Level the McCormick Place conference center. A than 9:00 am on the day of presentation. Presentation nurse/First aid administrator will be on duty during times for each author are listed at the beginning of key hours. the session. Your poster board number is the alpha/ numerical listing next to your abstract number.
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Sunday–Tuesday Wednesday
Location
Poster Set-up
Poster Viewing
Poster Presentation
Poster Tear-down
Hall F
7:00 am 9:00 am
9:00 am–4:00 pm
Times vary; see individual Society
4:00 pm–6:00 pm
Skyline Ballroom
7:00 am 9:00 am
9:00 am–4:00 pm
Times vary; see individual Society
4:00 pm–6:00 pm
Presenters are to stand at their poster board during the assigned time. Do not leave belongings, poster containers or any materials under the poster boards or in the poster area. EB Management is not responsible for articles left in the poster area. Pushpins are available at the Poster Attendant stations.
RESTAURANT RESERVATIONS AND CITY INFORMATION McCormick Place, West Level 3 Center Lobby Participants may obtain information about local restaurants and things to do in Chicago at the Concierge Desk located at the West Level 3 Center Lobby.
SPEAKER INFORMATION AND SPEAKER PREVIEW ROOMS McCormick Place, W182, W191, S101A Speakers are not required to bring a laptop! All Presenters must be at their poster boards during session rooms will be equipped with a data projector assigned session presentation times, as designated by and computer. Bring presentations on a Windowseach society. readable USB flash drive or CD. Back-up presentation Posters must remain on display all day from formats are recommended. Please visit our website under general information for instructions on preparing 9:00 am–4:00 pm. your presentation www.experimentalbiology.org. Posters that do not remain on display all day during their assigned day may, at the discretion of the Speakers should visit the Speaker Preview Room to review and check presentation compatibility at programming society, be ineligible for awards. least 4 hours prior to their session. Speakers must Recording (photographing, audio taping or videotaping) arrive half an hour prior to scheduled start time any presentation/session is PROHIBITED, except by to allow technicians time to load the presentation an EB-authorized agent or by first authors who want onto the computer. Additional audio visual to photograph their poster presentation. equipment must be requested in advance via email at
[email protected] or by contacting the Society that programmed your Program Printed programs WILL NOT be distributed. Program abstract or invited you to give a talk. information as well as the app will be available for The Speaker Preview Rooms will be open during the online downloading prior to the meeting. following times: RECORDING Room W182, Phone: 312-949-8620 Photographing, audio taping, videotaping any Saturday–Wednesday, 7:00 am–6:00 pm presentation (oral or poster) or exhibit display is Room W191, Phone: 312-949-8621 prohibited, except by an Experimental Biology Saturday–Wednesday, 7:00 am–6:00 pm authorized agent for official purposes, or by first Room S101A, Phone: 312-949-8622 authors who want to photograph their own poster Saturday–Wednesday, 7:00 am–6:00 pm presentation. Any policy violations will result in being asked to leave. Poster Presentation Policy: Presenters must hang their posters no later than 9:00 am on their day of presentation.
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SPECIAL NEEDS Registrants with special needs should contact the EB Meeting Management Office in advance at
[email protected]. For onsite inquiries, please contact the Meeting Management Office in Hall F, Registration B of the McCormick Place. For specific information on the McCormick Place’s accessibility, contact the Guest Services Department at 312-791-7104. The McCormick Place staffs the Information Desk in the West Level 3 Center Lobby of the McCormick Place and is able to provide accessibility information for local area attractions. For information on Chicago area attractions, visit our EB2017/Chicago Microsite for more information www.choosechicago.com/ExperimentalBiology2017.
Taxi Service Taxis are plentiful and easy-to-hail in downtown, and offer a convenient way to get around the city. Taxis charge a base rate of $2.25 for the first 1/9 mile, plus, $.20 for each additional 1/9 mile. If a gas surcharge is in effect, a sign will be displayed inside the taxicab and a surcharge may apply. Tolls are an extra charge; taxis charge $1 for the first additional passenger over age 12 and under age 65. Each additional passenger after first passenger, over 12 and under 65 is $.50. It is standard to tip the driver about 15–20 percent of the fare, plus $1–2 per bag if the driver helps you with luggage.
TRANSPORTATION O’Hare International Airport, located 13 miles from downtown, is one of the largest airports in the world. For visitors needing information or directions, airport information booths are located on the lower levels of the domestic terminals and on the upper and lower levels of the International Terminal.
METRA Commuter Rail The high-speed Metra train connects outlying suburbs to downtown and is an easy way to get into the heart of the city fast. For fares and maps, visit METRA’s website at metrarail.com.
Please note that all fares are subject to change.
YOUNG EXPERIMENTAL SCIENTISTS (Y.E.S.) MIXER Midway International Airport is located 10 Hilton Chicago, Continental Ballroom miles from downtown Chicago and offers another The Y.E.S. Mixer is open to all EB registrants and is scheduled Monday, April 24, 8:00 pm–11:30 pm. You convenient travel option for visitors. must wear your badge to gain admittance. Dance, relax, and network while enjoying complimentary GROUND TRANSPORTATION Both airports offer plentiful taxi service to downtown snacks and soft drinks. EB host societies encourage and the suburbs. Rates range from $40–$50 from responsible drinking and will only serve alcohol to O’Hare, and $30–$40 from Midway. Rates vary based those above the age of 21 with proper identification. on travel time and are subject to change. Hotel Shuttle Service: Complimentary bus service is available between the McCormick Place and the contracted EB hotel community. Please reference below for specific pickup locations/routes. A transportation agent will be available at each designated hotel, during the morning hours. The shuttle bus drivers will not make additional stops. The shuttle bus drop-off and pick-up location at the McCormick Place is at Transportation Gates 43 and 44 on Level 1. If you need special assistance, such as a wheelchair lift, please contact the Transportation Services desk at: 1-888-441-7575. Buses run on average every 10–15 minutes.
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Experimental Biology exhibitors offer the best tools and resources available in research today! Join the exhibitors at 10:00 am for coffee and 2:00 pm for snacks and learn the latest and greatest from more than 300 companies.
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Hilton Chicago Lobby Level 720 South Michigan Avenue Chicago, IL 60605 Phone: 312-922-4400
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Hilton Chicago Second Floor 720 South Michigan Avenue Chicago, IL 60605 Phone: 312-922-4400
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EB-SPONSORED SPECIAL PROGRAMS NIH GRANT SEMINAR WORKSHOP SERIES Convention Center, Career Center Area, Hall F2
equivalent). Among the K awards discussed will be the K01 Mentored Research Scientist Development Award, the K02 Independent Scientist Award, the K22 Career Transition Award, the K08 Mentored Clinical Scientist Development Award, the K23 Mentored Patient Oriented Career Development Award, the K24 Mid-Career patient Oriented Career Award, and K25 Mentored Quantitative Scientist Career Development Award. The interactive discussion will give attendees an opportunity to ask questions of and obtain insight from an NIH representative on these and other awards available for beginning investigators.
The FASEB Office of MARC and Professional Development Programs in association with the Experimental Biology 2017 (EB2017) Management Committee will sponsor career development seminars and a NIH Grant Seminar Workshop in the EB2017 Career Center located in Hall F2 of the McCormick Convention Center. There is no fee or pre-registration associated with the workshops and seminars; however, EB2017 meeting registration NIH FELLOWSHIP (F) AWARDS is required to participate in all seminars/ sessions. Handouts and resource materials will be provided onsite. Advance seating reservations are 1:00 pm–2:30 pm, Monday/Tuesday, Career Center, Hall F2 not required. This presentation will focus on the NIH’s Ruth Critiquing of CV/resumes and the career coaching/ L. Kirschstein National Research Service Awards counseling sessions will be by appointment only (NRSA). The NRSA research training fellowship (F) and the times are as follows: Saturday, April 22, awards are targeted to individuals with or seeking in the registration area, Sunday, April 23–Monday, research doctoral degrees (Ph.D. and equivalent) April 24, 9:00 am–5:00 pm and Tuesday, April 25, and clinical doctoral degrees (M.D. and equivalent). 9:00 am–4:00 pm in the FASEB Career Center. Among the F awards discussed will be the F30, Wednesday, April 26, 9:00 am–12:00 pm will take NRSA Individual Predoctoral MD/PhD or Other place in the Skyline Ball Room West 375A. Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual Predoctoral Fellowship, the F31 NRSA Individual Predoctoral Fellowship to Promote NIH CAREER DEVELOPMENT Diversity in Health-Related Research Award, the F32 (K) AWARDS NRSA Individual Postdoctoral Fellowship Award, and the NRSA Individual Senior Fellowship Award. 9:00 am–10:30 am, Monday/Tuesday, The interactive discussion will give attendees an Career Center, Hall F2 opportunity to ask questions of and obtain insight This presentation will focus on the NIH’s Career from an NIH representative on these and other awards Development Awards (K) including the most recent available for pre- and postdoctoral fellows and K99/00 Pathways to Independence Award (for senior investigators. postdoctoral scientists) and other K awards targeted to individuals with research doctoral degrees (Ph.D. and equivalent) and clinical doctoral degrees (M.D. and
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CAREER DEVELOPMENT SEMINARS & WORKSHOPS
Career/Planning for Academic/Career/Life Success.
9:30 am—How to Choose Your Ideal Career; presented by Bill Lindstaedt. Do you want to find a The following Seminars and Workshops will be held career path that you’ll enjoy and find rewarding? Of in the EB2017 Career Center. There is no fee or course! But HOW do you find such a path, especially pre-registration associated with the workshops and since there are so many different directions scientists can go with their careers? seminars; just walk in and sit down! Sunday, April 23, 2017 9:00 am—Networking: Optimizing Your Time at EB2017; presented by Joe Tringali. You surely have heard that networking is a key component of the successful job search. The term itself often conjures up negative thoughts and reactions to the uninitiated, sometimes to the point of paralysis. Professional conferences (such as EB 2017) provide endless networking opportunities. If, however, your perception of networking means tackling someone at the coffee station while thrusting your CV in his/ her hands, you may want to stop in on this session. The practice of networking has become so much easier with the advent of the internet. We will discuss what you hope to get out of your presence at the meeting, how to set objectives beforehand, and how to meet those objectives once you arrive (while minimizing anxiety). 9:00 am—Get Up With Something On Your Mind; presented by Howard Adams. Planning for academic/career/personal success is a process—a mode of striving to excel at any and all endeavors one undertakes. It is an ongoing process of planning, reviewing, refining, adjusting and/or changing goals, strategies and tactics to realize planned outcomes— achievement, success, recognition, rewards, power, etc. This seminar is designed to encourage individual responsibility for: 1) taking charge of one’s own success; 2) focusing on being proactive; 3) being open and responsive to change; 4) applying strategies to assess one’s skills, interests, and values on an ongoing basis; and 5) building support systems through effective utilization of mentoring and networking. Key topics: The Success Mind-set, Defining Purpose, Performance Curve, The Personal Audit, Academic/
There are more than FIFTY career options available to biomedical sciences PhD’s. If you’d like to see a list of these career options, while learning about how to select the best option for you, then don’t miss this thought-provoking and interactive workshop! Here you will learn about a logical, step-by-step process for exploring your career options and deciding which will provide the best fit for your own set of skills, values and interests. 10:00 am—Negotiation Strategies for Scientists; presented by Debra Behrens. This session introduces effective methods of negotiating with potential employers. Topics: The basic elements of successful negotiation, contexts of gender and culture, avoiding common pitfalls, leveraging your strengths, handling multiple offers, and closing the deal. 10:30 am—Understanding Search Committees & Finding Job Announcements; presented by Andrew Green. Are Postdocs Always Essential? What do search committees look for? How do I find academic jobs offered in my field, or within a specific geographical area? Answers to these and other questions presented by Andrew Green, a veteran of the academic job search and numerous search committees. 1:00 pm—But I Have No Skills! Exploring Myths and Exploring Career Options for PhDs; presented by John Lombardo. Are the skills you developed in graduate training really useful outside of the academic lab? Many PhD candidates and postdocs exploring careers beyond the academy assume— incorrectly—that employers will not find them or their skills attractive. In this session you will have the opportunity to identify skills that you currently possess, and also to find career fields that might be a good fit for these skills.
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11:00 am—Making Mistakes When Speaking: How to Handle Them; presented by Judy Blumenthal. Much attention, time and money are spent on polishing our interview behaviors. But when it comes to the real thing, we frequently find ourselves saying afterwards, “I can’t believe I said that or did this.”
1:00 pm—Creating Effective CV’s, Cover Letters, Research & Teaching Statements; presented by Andrew Green. Most of the cuts in the applicant pool are made solely on the basis of your written application materials. Do yours represent you in the strongest possible fashion? How should a cover letter and CV for Stanford differ from one addressed to faculty at San Jose State? And what exactly is a Statement of Teaching Philosophy. Advice will be provided on creating these documents and more for the academic job search.
Dr. Blumenthal will teach you how to identify “triggers”, antecedents to behaviors that cause us to say things or behave in ways we wish we didn’t. She will teach you how to identify triggers before they happen and increase your chance of demonstrating the right behaviors for winning the job. 1:00 pm—Networking With Strangers Is Required for Your Future; presented by Judy Blumenthal. 1:00 pm—Job Hunting in Biotech Part 1: Finding Networking is a crucial dimension of a job offer; from & Applying for Scientist Positions; presented by developing a resume to interviewing to the job offer. Bill Lindstaedt. In this seminar, you will learn how Where do I begin? What do I take for granted? How to prepare resumes and cover letters so you will do I communicate the right behaviors for the job? And be ready to search for research jobs in the biotech/ to whom? How much of the employer’s business do pharma industry. Then, you will learn how to find and I really have to know? To be at the right place at the connect with scientists working at companies. Finally, right time, sometimes it takes just one person. But you will learn how to execute job search strategies who is this person? necessary for success on the biotech/pharma job market. After this seminar you will understand how to In this seminar, you will learn how to move in the conduct the four job hunting techniques that comprise right direction and identify and approach the right people to help you obtain a job offer. You will learn a comprehensive job search in the biotech industry. essential behaviors that promote your case and that (This is part 1 of a 3-part series. Each seminar can be can be used quite favorably. taken separately but together they provide comprehensive 2:30 pm—Networking: A Required Life Skill; information about the industry job search process.) presented by Howard Adams. To succeed in today’s 1:00 pm—Handshakes, Eye Contact, Small Talk: competitive world of work, who you know can be as Networking Successfully as a Student or Postdoc; critical as what you know. Successfully networking, presented by Naledi Saul. In this interactive session, to develop contacts, is a required skill. Networking we’ll learn how to initiate, organize and maintain your involves 1) making contacts, 2) establishing cordial network to promote your academic and professional relationships, and 3) ultimately bonding to mutually success. You will practice starting conversations support each other and share information. This seminar about your professional interests and goals, and we explores skills and techniques germane to successful will discuss professional etiquette and strategies to networking. During the session, Dr. Howard Adams network. You will also sketch your own networking will cover the following key topics: 1) Dimensions of plan for a conference. Networking; 2) Networking to enhance one’s career/ professional development; 3) Networking concerns: How? When? Where? Why? 4) Tips for Successful Networking; 5) Do’s and Don’ts of Networking.
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3:00 pm—Job Hunting in Biotech Part 2: Interviewing for Scientist Positions; presented by Bill Lindstaedt. This seminar is designed to help you improve your interview skills so that you will be better prepared to land a scientist position in industry. At the end of the seminar, you will be able to:
3:30 pm—Making the Grade: Job Talk/Chalk Talk; presented by Debra Behrens. Participants will learn to plan, structure and deliver an effective job talk. This seminar will key elements of the job talk and finally, how to capture the interest of a diverse (faculty, administrators, students) audience.
˗˗ Respond effectively to the most common 4:00 pm—Nailing the Job Talk & Interview Prep; presented by Andrew Green. Going Live: questions asked during industry interviews Conference Interviews, On-Campus Interviews, The ˗˗ Answer behavior-based questions in an All-Important Job Talk, and Negotiating the Offer. organized manner Monday, April 24, 2017 ˗˗ Begin and end the interview experience with poise and professionalism 9:00 am—Beyond the Bench: Preparing for Your Career Transition in the Life Sciences; presented (This is part 2 of a 3-part series. Each seminar by Joe Tringali. Is there a way to move your skills can be taken separately but together they provide from the bench to a related career? There is, assuming comprehensive information about the industry job one is focused and willing to invest some time in search process.) making the switch. We will explore different paths to alternative scientific careers. 3:30 pm—Networking: Optimizing Your Time at EB2017; presented by Joe Tringali. You surely 9:00 am—Goal Setting, Prioritizing, Time have heard that networking is a key component of the Management; presented by Howard Adams. Most successful job search. The term itself often conjures students have dreams and aspirations regarding up negative thoughts and reactions to the uninitiated, academic, career and life ambitions. However, too sometimes to the point of paralysis. Professional often many fall short of realizing their dreams for conferences (such as EB 2016) provide endless lack of established goals and prioritized action steps. networking opportunities. If, however, your perception So they are left with questions such as these: 1) what of networking means tackling someone at the coffee am I going to do with the rest of my life? 2) What station while thrusting your CV in his/her hands, you are my academic/career goals and objectives? and may want to stop in on this session. The practice of 3) How do I use my time wisely to get from where networking has become so much easier with the advent I am now to where I want to be in the future? This of the internet. We will discuss what you hope to get out seminar is designed to answer these questions in the of your presence at the meeting, how to set objectives context of goal setting, prioritizing, time, and stress beforehand, and how to meet those objectives once you management. Key topics: Decoding the Goals Setting arrive (while minimizing anxiety). Process, Prioritizing to Determine what is Important, Translating Goals into Time Based Action Steps, Time Management and Avoiding Procrastination, Handling Stress and Anxiety.
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10:00 am—Interviewing Well: Interviewing While Pregnant: Successful Strategies; presented by Naledi Saul. Students/postdocs who are job/postdoc seeking pregnant can find it difficult to know when and how to disclose their pregnancy during a hiring process. The decision of how and when to discuss a pregnancy a personal one; based on a candidate’s personal values, how visible their pregnancy is, their tolerance for risk, their awareness of how family friendly their potential employer is, and their level of confidence about their ability to negotiate this situation skillfully. In this interactive session, we’ll give you the information and framework to determine the best time to disclose your pregnancy during the hiring process, as well as the language to discuss your pregnancy professionally. So whether you or someone you know is presently pregnant, you are thinking about expanding your family in the future, or plan to lead a team in the future and would like to know how to manage this skillfully, this session is for you! By the end of this session, you will be able to:
10:30 am—Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions; presented by Bill Lindstaedt. So you’ve landed a job offer for an industry scientist position! Now, how do you know if the compensation package is competitive, and how do you ask for more? In this seminar you will learn how to: ˗˗ Separate out the typical components of an industry job offer letter, so you know what to ask for ˗˗ Determine if an offer is competitive and when to ask for more ˗˗ Ask for additional compensation in a way that represents your interests while maintaining positive relationships (This is part 3 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.)
10:30 am—Identifying Your Options Using ˗˗ Describe factors that make it challenging to know ScienceCareers.org, LinkedIn & More; presented when and how to discuss your pregnancy during by Andrew Green. This presentation is designed a hiring process to provide you with strategies and resources for beginning to think about what kinds of professional ˗˗ Explain the protections and limits of The options outside of academia might be a good Pregnancy Discrimination Act (PDA)/ Title VII match for your skills and interests, and how to gain of the Civil Rights Act of 1964 access to additional information about those career ˗˗ Distinguish the five stages of a hiring process, and possibilities that will help clarify which options formulate a plan about what stage to discuss your warrant further interest and investigation. pregnancy during the hiring process ˗˗ Practice the professionally appropriate language to disclose your pregnancy to an employer
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11:00 am—Developing Your Core Message/”Elevator Pitch”; presented by John Lombardo. Your core message statement is a brief spoken statement (30-second mini-abstract) about you that lets people know who you are as a professional, what you do well, and what you expect to contribute. It is a wellprepared answer to the question, “Tell me a little bit about yourself.” A positive core message statement will enhance your professional presence and stature, boost self-confidence, and reduce anxiety. It helps you establish your identity as a professional scientist, and it helps open doors for connection, collaboration, and employment. This seminar will provide guidance in a safe place to develop and practice your statement. 1:00 pm—Job Hunting in Biotech Part 1: Finding & Applying for Scientist Positions; presented by Bill Lindstaedt. (This is part 1 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Sunday’s listing. 1:00 pm—Successful Behaviors for Winning an Interview; presented by Judy Blumenthal. Eye contacts, arriving on time- these are given behaviors for any interview of any type and everyone knows them. The successful behaviors for winning an interview are those that categorize you as a high risk or low risk for the next recruitment step. In this seminar, you will learn what behaviors are important to exhibit on an interview, and how employers evaluate these behaviors to determine whether or not you are a low risk and move you on to the next recruitment step, or a high risk and don’t.
1:00 pm—Building Your Skills, Networking & Informational Interviews; presented by Andrew Green. You’ve begun to identify some potential new career paths, but how do you build on these sparks of interest, learn more about the day-to-day content of a given field, and find individuals working in that career who can answer your questions and help you build a network in your emergent profession. This presentation will discuss how to utilize Linkedln, professional associations, and other networking opportunities to increase your knowledge base and create opportunities for informational interviews. 2:30 pm—Job Search in Academia & Industry: Timelines and Effective Strategies; presented by Debra Behrens. Are you on the market for both academic and industry jobs, but aren’t sure where to start? Learn strategies for successfully navigating the two-track job search. Topics: Organizing your search, timelines/logistics, researching employer organizations, presenting your qualifications and evaluating job offers. 2:30 pm—Ten Tough Industrial Interview Questions (and Ten Pretty Good Responses); presented by Joe Tringali. You’ve been invited to interview with that drug development company that you’ve always wanted to work for. You’ve soaked up the position description, and are confident in your ability to do the job, as well as answer any/all technical questions during the interview process. The day is yours…until that first question catches you by surprise and your confidence begins to wilt. Be prepared for those non-technical questions that you will almost certainly hear at some point, know why they are asked, and learn what good (if not great) responses to those questions might be in this workshop.
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2:30 pm—Making the Case for Graduate School; presented by Howard Adams. Advanced degree level training has emerged as a key requirement for garnering positions of leadership in academia, government, and industry and for careering in today’s workplace. Beyond this, an advanced degree signal scholarship, maturity, and the capacity to do rigorous work; all attributes that can provide an edge in the workplace. This seminar explores graduate education in the context of: 1) a career enhancement strategy; 2) graduate study opportunities/options; 3) how-to negotiate the graduate school admission and financial aid process, and 4) placing graduate studies in one’s overall academic/career/life plans. Key topics: Making the Case for Graduate School, The Application/ Admissions Process, funding for Graduate Work, and Putting the Pieces Together for a Smart Application. 3:00 pm—Ten Ways to Get Lucky in the Job Search; presented by Phil Clifford & John Lombardo. Although it is important to have a plan for your career progression, it is just as important to take advantage of unexpected events along the way. This seminar will suggest specific ways to foster chance occurrences that may influence your job search. We will examine ten practical suggestions to prepare you to make happenstance work positively for you. 4:00 pm—Job Hunting in Biotech Part 2: Interviewing for Scientist Positions; presented by Bill Lindstaedt. (This is part 2 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Sunday’s listing. 4:00 pm—Making the Grade: Job Talk/Chalk Talk; presented by Debra Behrens. See description on Sunday’s listing.
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4:00 pm—Attitude & Behaviors: How Are You Perceived?; presented by Judy Blumenthal. Every person carries within them thoughts, feelings, and emotions that influence the way we are perceived by others, and the way we behave. This interaction (perceptions of others and our behavior) is so very complex, and happens so quickly, that perceptions are not necessarily at a conscious level and therefore opinions about you can be formed before you even have a chance to make any corrections to your attitude or behavior. This is a serious consequence during the job search, and a consequence we want to do without. Dr. Blumenthal will teach you how to present yourself in your resume, on the interview, and subsequent follow ups, including the job offer. She will teach you what goes on behind the scenes regarding attitudes and behaviors so that you have more leverage on your side. The end result is a positive consequence increasing the likelihood of job interviews and a job offer. Tuesday, April 25, 2017 9:00 am—Attitudes in Academic and Employment Achievement; presented by Judy Blumenthal and John Lombardo. Attitude is one of the strongest nonverbal determinants of academic and employment achievement especially in competitive settings, yet it is rarely addressed as an important behavior for applicants to focus on. Attitudes are complex circular designs since each established attitude creates a perception, which establishes an attitude, and the cycle continues. Attitude and dyadic interactions are known to be complex. Add group and panel interviews to this, and attitudes of the applicant can catapult the individual to a successful outcome, or discontinue the applicant’s competition early in the process. The authors will present a behavioral analysis of an
attitude, teach how to modify or change attitudes for success and effectiveness, and present cases they experienced pertaining to attitudes in academic and employment competition. Attendees will learn how to generalize the material to their own social function opportunities that can provide additional benefits to competition in their respective settings. They will learn highly effective attitudes and how to develop them for competitive job search and educational promotion situations for professionals.
10:30 am—Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions; presented by Bill Lindstaedt. (This is part 3 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Monday’s listing.
10:30 am—But I Have No Skills! Exploding Myths and Exploring Career Options for PhDs; presented by John Lombardo. See description on 9:00 am—What You Seek Is What You Get; Sunday’s listing. presented by Howard Adams. It is generally agreed that sharing in a mentoring relationship can 1:00 pm—How to Choose Your Ideal Career; boost one’s career/professional/technical growth presented by Bill Lindstaedt. See description on and development. One common concern of some Sunday’s listing. professionals in today’s workplace regarding mentoring is this: “Since I am not privileged to have formal mentoring available to me, how do I find and choose a mentor on my own?” This seminar provides an overview of essential strategies for identifying, screening, selecting, and using a mentor(s). Key topics: ˗˗ Decoding the Language of Mentoring. ˗˗ Establishing Mentoring Needs and Expectations. ˗˗ Identifying, Screening, and Selecting a Mentor. ˗˗ Building a Mentorship Alliance.
1:00 pm—Talking About Yourself: How to Interview Well; presented by Naledi Saul. In this session, we will help you learn how to interview successfully, by looking at the interview process from employer’s perspective. We will discuss the overall hiring process and the all-day interview format, as well as the steps to prepare for an interview, effectively use the different types of interview questions to both present your skills and experience, and assess the employer’s needs, and criteria to ultimately determine if the position is a good fit for you.
˗˗ Developing Mentorship Goals and Action Steps. 10:00 am—Translating Your Credentials on Paper (CV=>Resume) and in Person; presented by Andrew Green. Now that you’ve completed the exploration phase, and honed in on your new professional areas of interest, how do you present yourself on paper and in-person as a compelling, credible candidate. This presentation focuses on how to transform your academic CV into an effective resume, as well as, how to write a strong cover letter and prepare for future interviews.
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1:00 pm—Navigating Doctoral Work Protocols/ Milestones/Requirements; presented by Howard Adams. Success in graduate school starts with goal setting and the formation of an action plan to achieve desired results -obtaining the degree sought. The graduate study plan should delineate 1) what is to be accomplished in terms of expectations, degree requirements, and program milestones; 2) action steps that establish priorities for tasks to be completed; 3) process for implementing action steps; and 4) time frame for meeting program requirements and milestones. Session participants will be guided through exercises and provided with templates for developing a graduate program plan. Session topics: Planning in the context of the Graduate School Process, Establishing Realistic Program Goals, Objectives, and Milestones, the Planning ProcessWriting and Implementing a Graduate Degree Plan, and Charting Milestones to Monitor Progress and Refine Actions Steps. 2:30 pm—Selling Yourself to the Life Sciences Industry; presented by Joe Tringali. The industrial employer is often looking for a different set of skills, attitudes, and interview responses than those sought by academic or government research institutions. In this workshop, we will explore the who, what and why of the pharmaceutical and biotechnology industries as they pertain to their hiring processes. Discussions will focus on the development and positioning of your marketing message in order to improve the odds of a successful industry job search.
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3:00 pm—Global Interview Skills: A Practice Workshop for International Candidates; presented by Debra Behrens. This interview practice workshop is customized for international job candidates. The key topics are: The four central questions in virtually every employment interview, understanding cultural and communication dynamics, the STAR method, and how to use “small talk” for big results. 3:00 pm—The Strategic Postdoc: How to Find & Leverage Your Postdoc Experience; presented by Andrew Green. Many PhDs just kind of fall in to a postdoc, rather than thinking about it from a strategic perspective. Your postdoc is never an end in itself; rather it’s a means to another end whether that goal is a faculty position at a research university, a small college, national lab, or perhaps an industry job. Learn how to find postdoc opportunities that will best prepare you for that next step, and how to use your postdoc experience to facilitate the transition to your next position.
FRIDAY, APRIL 21 Biochemistry and Molecular Biology 1.
ASBMB GRADUATE AND POSTDOC TRAVEL AWARD NETWORKING RECEPTION
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Special Event Fri. 5:00 pm—Hyatt Regency McCormick Place, DuSable ABC Chaired: C. Heinen and T. O’Connell Start making connections with fellow Graduate Student and Postdoctoral Travel Awardees before the meeting even begins. This is also an opportunity to meet and network with many of Saturday’s Career Development Program invited presenters. Invitation only.
Nutrition 2.
FOOD SYSTEMS, NUTRITION AND HEALTH IN A CHANGING ENVIRONMENT: A WORKSHOP TO BUILD CONNECTIONS TO ADDRESS GLOBAL PRIORITIES ASN Satellite Fri. 8:00 am—McCormick Place Convention Center, S100A Chaired: J. Finley and D.J. Raiten
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Introduction to Session I: The Challenge: The Interaction of Agriculture, Environmental Change and Nutrition in Shaping Public Health: A Global Perspective. Lynnette Neufeld. Global Alliance for Improved Nutrition. 8:15 The Global Health Context: Colliding Epidemics. Daniel Raiten. Eunice Kennedy Shriver National Inst. of Child Health and Human Development. 8:40 Shaping Food and Agricultural Policy to Address Global Health. Stuart Gillespie. International Food Policy Research Inst. 9:05 Nutrition and Food Production in Transition: Impact of Changing Demographics, Economics and Personal Choice on Nutrition and Public Health. Walter Willett. Harvard T. H. Chan Sch. of Public Health. 9:30 Global Environmental Stress. Matthew Smith. Harvard T. H. Chan Sch. of Public Health. 10:55 Introduction to Session II: Meeting the Challenge: Sustainabile Food/Agriculture Solutions for Improving Nutrition and Public Health: Possibilities and Pitfalls. Barbara Schneeman. USAID.
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Avoiding Unintended Consequences. Lindsay Allen. USDA ARS Western Human Nutrition Research Ctr. 11:20 Plant-Based Food Systems: The Place of Agriculture Products within Context of a Healthy Diet. Ross Welch. Cornell Univ. 11:40 Animal-Based Food Systems: The Place of Agriculture Products within Context of a Healthy Diet. Alison Van Eenennaam. Univ. of California, Davis. 12:00 Case Study: Dairy Research: An Example of an Integrated Approach to Production, Environment and Human Health. Greg Miller. National Dairy Council. 12:35 The Agriculture/Food System: Global Status and Challenges that Impact Public Health. Sonny Ramaswamy. USDA National Inst. of Food and Agriculture. 1:20 Food Quality vs. Quantity in a Changing Population and Environment. Naomi Fukagawa. USDA-ARS. 2:25 Introduction to Session III: Considerations for Success and Engagement for Moving Forward. Dave Gustafson. ILSI Research Foundation. 2:30 Approaches to Research at the Intersection of Agriculture, Nutrition and Environment. John Finley. USDA ARS. 2:50 Agriculture-Nutrition Linkages in USG Global Food Security Program. Robert Bertram. USAID. 3:10 Big Data, the Ontology of Agriculture, Nutrition and Public Health, and Challenges of Speaking a Common Language. Sander Janssen. Wageningen Univ. and Research. 3:30 Using Public Private Partnerships to Facilitate Big Picture Research. Sylvia Rowe. SR Strategy. 4:00 Panel Discussion 5:15 Next Steps and Closing Comments. Gerald Combs. Cornell Univ.
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THE GLOBAL NUTRITION TRANSITION AND IMMUNE FUNCTION: THE CHALLENGES OF OVERNUTRITION AND UNDERNUTRITION IN VULNERABLE POPULATIONS
FRIDAY
ASN Satellite
CARIG FORUM: MOVING TOWARDS PERSONALIZED NUTRITION OF DIETARY CAROTENOIDS: A REVIEW OF THE GENETIC AND NON-GENETIC FACTORS IMPACTING ABSORPTION, METABOLISM, AND HEALTH IMPACTS
Fri. 8:00 am—McCormick Place Convention Center, S105BCD
Forum
Impact of Nutrition in the Global Nutrition Transition and Immune Function: The Public Health Perspective. David Heber. UCLA Ctr. for Human Nutrition. 8:45 Vitamin D and Immune Function: How Much is Enough? Michael Holick. Boston Univ. Med. Ctr. 9:15 Omega-3 Fatty Acid Modulation of Immunity, Inflammation and Cardiometabolic Disease Risk. Philip Calder. Univ. of Southampton. 10:00 Nutritional Modulation of the Microbiome and Immune Function: Where We are Today and Future Research Directions. Ian Rowland. Univ. of Reading. 10:30 Vitamin A and Carotenoids as Immunoactive Compounds. Charles Stephenson. USDA ARS Western Human Nutrition Research Ctr. 11:00 Immune Function and Micronutrient Status in Overweight and Obesity. Simin Meydani. Tufts Univ.
4.
Fri. 1:00 pm—McCormick Place Convention Center, S105A
8:00
2
Chaired: J.W. Erdman and N.E. Moran 1:15
James A. Olson Memorial Lecture: New Epidemiological Evidence on the Relationship between Carotenoids and Breast Cancer Risk. A. Heather Eliassen. Harvard Sch. of Public Health. 2:00 Introduction. John Erdman. Univ. of Illinois at Urbana-Champaign. 2:10 Genetic and Non-genetic Factors Impacting Carotene Absorption, Distribution and Metabolism. Nancy Moran. USDA ARS Children’s Nutrition Research Ctr. 2:45 Health Aspects of Carotenes. John Erdman. Univ. of Illinois at Urbana-Champaign. 3:20 Break. 3:30 Factors Impacting Xanthophyll Absorption, Distribution and Metabolism and Health Aspects of Xanthophylls. Elizabeth Johnson. Tufts Univ. 4:15 Panel Discussion: What are the Critical Variables Impacting Carotenoid Responses and What are the Critical Questions yet to be Answered? John Erdman. Univ. of Illinois at Urbana-Champaign.
SATURDAY ANATOMY
SATURDAY, APRIL 22 Anatomy 5.
IS A BALANCED TEACHING/RESEARCH CAREER FACT OR FICTION
7.
Symposium
Symposium
Sat. 1:30 pm—McCormick Place Convention Center, W175AB
Sat. 8:30 am—McCormick Place Convention Center, W176AB
Chaired: J. Feng
Chaired: L. Opperman Professional Development 8:30
The Facts and How to Plan for a Balanced Career. Lynne Opperman. Texas A&M University College of Dentistry. 8:45 Perspectives from a Chair of a Teaching Intensive Institution. Judith Venuti. Oakland University William Beaumont School of Medicine. 9:00 Perspectives from a Chair of a Research Intensive Institution. Kathryn Jones. Indiana University School of Medicine. 9:15 Achieving a Research and Teaching Balance: One Junior Faculty Member’s Experience. Margaret McNulty. Indiana University School of Medicine. 9:15 Discussion.
6.
Bones/Muscle/Connective Tissue 1:30 7.1 Osteocytes Play a Key Role in the Formation and Maintenance of Mineralized Bone. Y. Ren, J.Q. Feng. Duke University School of Medicine and Texas A&M College of Dentistry. 2:00 7.2 Osteocytes, Muscle and Exercise: Role in Healthy Aging. L. Bonewald. Indiana University. 2:30 7.3 Osteocytes Orchestrate Mechanical Signal Transduction in Bone via WNT. A. Robling. Indiana University School of Medicine.
8.
Sat. 1:30 pm—McCormick Place Convention Center, W175C Chaired: J. Organ Professional Development
Symposium
Chaired: R. Lufler Professional Development 10:30
It Takes a Village: Survival Strategies for the Tenure Track. Rebecca Fisher. University of Arizona College of Medicine-Phoenix. 10:50 Gulliver’s Conundrum: Balancing life with the Constant Productivity Pressures at Research Institutes. Paul Trainor. Stowers Institute for Medical Research. 11:10 Building Your Career and Family: How to Make Your Mark while Striking a Balance. Rebecca Lufler. Tufts University School of Medicine. 11:30 How to Stumble and Make it Look Like You’re Dancing. Jason Mussell. Louisiana State University Health Sciences Center—New Orleans. 11:50 Discussion.
STORYTELLING AND THE ART OF EFFECTIVE SCIENCE COMMUNICATION Symposium
WORK-LIFE BALANCE AND MENTAL HEALTH: HOW TO MANAGE ONE WITHOUT LOSING THE OTHER
Sat. 10:30 am—McCormick Place Convention Center, W176AB
THE MIGHTY OSTEOCYTE: NO BONE ABOUT IT
1:30 1:40
Chair’s Introduction. Connecting with Your Audience. Jonathan Rossing. Gonzaga University. 2:15 Distilling Your Message. Krista Hoffmann-Longtin. Indiana University—Purdue University Indianapolis. 2:50 Wrap-up. Jason Organ. Indiana University School of Medicine.
3
S A T
ANATOMY
9.
THE ANATOMY OF CELL SHAPE
SATURDAY
11.
Symposium
Symposium
Sat. 1:30 pm—McCormick Place Convention Center, W176AB
Sat. 3:30 pm—McCormick Place Convention Center, W175AB
Chaired: T. Tootle
Chaired: M. Elsalanty
Cell Biology 1:30 9.1 Desmosomal Cadherin Association with a Dynein-Cortactin Complex Promotes Actin Rearrangements Required for Epidermal Morphogenesis. K.J. Green, O.Y. Nekrasova. Northwestern Feinberg School of Medicine. 2:00 9.2 AMPK: A Novel Link Between E-Cadherin Mechanotransduction and Cell Metabolism. K. DeMali, J. Bays, H. Miller, C. Heidema. University of Iowa. 2:30 9.3 Prostaglandins Regulate Mechanotransduction to the Nucleus. T. Tootle, E. Toombs, M. Lamb. University of Iowa.
10.
Bones/Muscle/Connective Tissue
BUILDING THE BRIDGE: CONNECTING PRIOR KNOWLEDGE TO NEW KNOWLEDGE HYBRID
3:30 11.1 Extracellular microRNA in Age-Related Bone Loss. M. Hamrick. Medical College of Georgia. 4:00 11.2 Why Does Bone Remodel, What Happens When It Doesn’t, and How Can We Use This to Change Our Therapeutic Mindset? D.B. Burr. Indiana University. 4:30 11.3 Dietary Kynurenine, the Oxidized Metabolite of Tryptophan, Suppresses Osteoprogenitor Expression of Hdac3 Resulting in Increased Marrow Adiposity and AgeRelated Bone Loss. M. McGee-Lawrence, J. Pierce, K. Yu, C. Davis, A. Dukes, Q. Zhong, J. Xu, W. Bollag, M. Elsalanty, E. Kennedy, K. Ding, W. Hill, M.W. Hamrick, C. Isales. Medical College of Georgia and University of Georgia.
Hybrid Symposium
12.
CARDIOVASCULAR BIOLOGY PLATFORM
Sat. 1:30 pm—McCormick Place Convention Center, W178A
Platform
Chaired: K. Cassidy and J.B. Barger
Sat. 3:30 pm—McCormick Place Convention Center, W175C
Education
Chaired: E. Dedkov
1:30 10.1 The Potential of Anatomy Ontology in Anatomy Education. J. Barger. University of Alabama School of Medicine. 2:00 10.2 Strategies for Enhancing Longitudinal Teaching of Anatomy Across a Revised Medical School Curriculum. A. Pearson, C.C. Pettepher, J.S. Halle, L.B. Nanney, A.F. Dalley. Vanderbilt University Medical Center and Belmont University. 2:15 Improved Medical Student Perception of Ultrasound Using a Paired Anatomy Teaching Assistant and Clinical Instructor Model. J. Smith, J. Kendall, D. Royer. University of Colorado School of Medicine. (582.23) 2:30 10.3 Previous Experience and Parental Perspectives: Influences on Study Habits in Anatomy. P. Husmann. Indiana University. 2:45 10.4 Mens Sana in Corpore Sano—A Pilot Course in Mind Body Medicine for Undergraduate Medical Students. D. Resuehr, L.T. Cotlin, S.F. Galin. UABSOM and UAB.
4
BONE REMODELING IN HEALTH, DISEASE, AND AGING
Cardiovascular Biology 3:30 Ventricular Growth and Coronary Vessel Development in the Giant Danio (Devario aequipinnatus) Heart. O. Shifatu, S. Glasshagel, P. Patel, H. Nelson, W. Tomamichel, C. Higginbotham, P.J. Lafontant. DePauw University. (586.13) 3:45 12.1 Role of Ajap1 in Cardiovascular Development. A. Poles, G. Gorski, E. Caskey, J. McEldrew, P. Ottman, C.J. Hatcher. Philadelphia College of Osteopathic Medicine. 4:00 12.2 Novel Contributions of an Extracellular Matrix Molecule to Coronary Vessel Formation. A. Bueker, A. Poles, G. Gorski, C.J. Hatcher. Philadelphia College of Osteopathic Medicine. 4:15 12.3 Genetic Lineage Tracing Analysis of Endothelial Cells in Lung Vascular Injury Identifies Two Distinct Sources of Endothelial Regeneration. M. Liu, H. Gong, L. Zhang, S. Xiong, J. Rehman, A.B. Malik. University of Illinois College of Medicine.
SATURDAY ANATOMY 4:30 12.4 Sox17-Mediated Conversion of Fibroblasts Into Endothelial Cells and Erythroblasts Enhances Neovascularization After Myocardial Infarction. L. Zhang, A. Jambusaria, Z. Hong, G. Marsboom, Y. Yuan, P. Toth, B. Herbert, A.B. Malik, J. Rehman. University of Illinois at Chicago and Indiana University School of Medicine. 4:45 12.5 HIF1α Activated Etv2 and Notch1 Signaling Biphasically Mediates ESC Differentiation to Arterial Endothelial Cells with Enhanced Sequestration in Ischemic Tissue. J. Hyun, K. Tsang, K. Cheng, M. Vargas, Y. Komarova, D. Mehta, M. Fukai, J. Rehman, A. Malik. University of Illinois at Chicago.
13.
SINGLE CELL ANALYSIS IN DEVELOPMENTAL BIOLOGY Symposium Sat. 3:30 pm—McCormick Place Convention Center, W176AB Chaired: P. Kulesa Developmental Biology/Morphology
Spatially Resolved Single-cell Transcriptomics. Jeffrey Moffitt. Harvard University. 4:00 Exploring Multi-dimensional Imaging: From Single Cell to Embryo Development. Francesco Cutrale. University of Southern California. 4:30 Single-cell Biology: Method Development and Applications on the Study of the Human Brain in Health and Disease. Spyros Darmanis. Stanford University.
14.
SO YOU WANT TO CREATE DIGITAL MEDIA FOR EDUCATION—NOW WHAT? Symposium Sat. 3:30 pm—McCormick Place Convention Center, W178A
S A T
Chaired: C. Krebs Education 3:30 14.1 If a Picture Already Tells a Thousand Words, How Many More Do We Need to Add? J. Bretschneider, Z. Rothman. VU University Medical Center Amsterdam, Netherlands and University of British Columbia, Canada. 4:00 14.2 How to create interactive digital resources that result in real learning outcomes. P. Rea, C. Krebs. University of Glasgow, United Kingdom, and University of British Columbia, Canada. 4:30 14.3 An Active Partnership: How Engaging Students as Co-Producers Will Change Your Classroom. F. Bengtson, M. Granmo. Lund University, Sweden and Linnaeus University, Sweden.
3:30
15.
WELCOME AND KEYNOTE SPEAKER Keynote Lecture Sat. 5:30 pm—McCormick Place Convention Center, W178A Welcome and introduction by AAA President, Kimberly Topp
5:30 Introduction. 5:40 15.1 Roles of Vascular Endothelial Growth Factor in Skeletal Development, Postnatal Homeostasis and Disease. B.R. Olsen, A.D. Berendsen, X. Duan, K. Hu, M. Nagao. Harvard School of Dental Medicine. 6:30 Discussion.
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BIOCHEMISTRY SATURDAY
Biochemistry and Molecular Biology 16.
ASBMB GRADUATE STUDENT AND POSTDOCTORAL FELLOW CAREER DEVELOPMENT EVENT
19.
Workshop
Special Event Sat. 8:30 am—McCormick Place Convention Center, W183C Chaired: C. Heinen and T. O’Connell Advance event registration required. Required participation by all Graduate/Postdoctoral Travel Awardees, including recipients of the Graduate Student Travel Awards supported by the ASBMB Minority Affairs Committee. Before you dig into the nitty-gritty of the very best molecular biology and biochemistry at the ASBMB annual meeting, join your peers for this day of networking, exploring careers and developing professional skills.
17.
ASBMB UNDERGRADUATE STUDENT ORIENTATION Special Event
Sat. 4:00 pm—McCormick Place Convention Center, W183AB Scientists from all career fields will meet with students and share advice about their career paths. All undergraduate students are encouraged to attend.
20.
Sat. 4:00 pm—McCormick Place Convention Center, W375C Outreach posters will be manned before and after the ASBMB Opening Lecture which takes place in the same room. Manning times: 4:00–5:15 pm and 6:30–7:00 pm. 4:00 4:00
Chaired: J. Provost
4:00
First time at a national meeting? What now? Learn how to develop a game plan to get the biggest bang for your buck during your time at the meeting.
4:00 4:00
Orientation open to all undergraduates attending the poster competition. No registration required. All ASBMB undergraduate travel award winners are required to attend.
4:00
18.
4:00
Special Event Sat. 11:30 am—McCormick Place Convention Center, W375B Chaired: K. Cornely, K. Dickson and P. Ortiz Advance competitor registration required. Competitors may check in and set up posters beginning at 11:30 (board assignments distributed at check-in). Posters must remain on display 12:30–4:00 pm. Undergraduate biochemists and molecular biologists will present their research and gain valuable practice in advance of presentations during the ASBMB annual meeting. Best Poster winners announced Sun, Apr 24, 12:30 pm, Room W184bc. Graduate program recruiters will be on hand to share exciting graduate opportunities.
6
SCIENCE OUTREACH POSTER SESSION Poster Discussion
Sat. 11:00 am—McCormick Place Convention Center, W183AB
ASBMB UNDERGRADUATE STUDENT POSTER COMPETITION
EXPLORING CAREERS SPEED NETWORKING EVENT
4:00 4:00 4:00 4:00 4:00 4:00 4:00
Board 1: CSI: Choosing Science and Innovation. B. Lehrman. Board 2: Promoting STEM awareness in East Texas: Stephen F. Austin State University ASBMB Student Chapter. C. Tovar. Board 3: Take Your Vitamins! Suffolk ASBMB Student Chapter Outreach Activities. C. Peterson. Board 4: BlastOff! with Biochemistry. G. Le. Board 5: Middle School Science Educational Outreach Programs: “Present Your Ph.D. Thesis to a 12-yearold” and “Shadow a Scientist”. G. Clark. Board 6: Project CRYSTAL (Colleagues Researching with Young Scientists: Teaching And Learning): A Scientific Outreach Program for Middle School Students. H. Holden. Board 7: Science Explorers: Small Group Mentoring/ Tutoring During the School Day to Help Underserved Chicago Public School Students Transition Into High School. J. Hatfield. Board 8: Scientific Community Outreach in Central Texas. K. Lewis. Board 9: Science in the News: Communicating science to the general public. K. Wu. Board 10: Promoting Science through a Science Club to Science Club initiative. K. Hicks. Board 11: Fostering of a Love of Science and Science Education. L. Zhao. Board 12: Teaching-learning model of science at an informal environment with an emphasis on active participation. M. Pérez-Oquendo. Board 13: Students Sharing Science: Cal Poly SLO Student Chapter Outreach. M. Hansen. Board 14: Promoting rural student enthusiasm for STEM by establishing a model biotechnology company in their high school. M. Koci.
SATURDAY BIOCHEMISTRY 4:00
4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00
21.
Board 15: Long-term research projects between students from the ASBMB student chapter at Hampden-Sydney College and Prince Edward High School, Virginia. M. Wolyniak. Board 16: Communication Training and Outreach Programs at Northwestern. M. Paulsen. Board 17: University of Texas Health Science Center at San Antonio Outreach: Meshing Science and Culture. M. Sifuentes. Board 18: “Science for the Curious” through Beer, Whiskey, Chocolate, GMOs, Pi(e), Films, and ‘Game of Thrones’. M. Metzler. Board 19: Expanding Your Horizons Connects STEM Professionals With Middle School Girls. M. Beck. Board 20: Jugando con la Ciencia—Northwestern University. N. Martinez. Board 21: New Beginnings-Our First Experience As a New ASBMB Student Chapter. P. Mullen. Board 22: Enhancing Critical Thinking Skills of High School Science Students: an Outreach Project. P. Williams. Board 23: Fired Up for Science: Engaging Community and Science Majors. T. Clark. Board 24: The ASBMB Student Chapter at Otterbein University: Best Practices and Outreach Efforts. T. Hyatt. Board 25: Discovery Outreach and The Wisconsin Science Festival—Growing a Statewide Footprint for Informal Science Engagement. W. Marner. Board 26: Outreach in New York City! The ASBMB Student Chapter at Marymount Manhattan College. A. Aguanno. Board 27: Informal STEM Education: Resources for Outreach, Engagement and Broader Impacts. C. Garibay. Board 28: “Science Fiesta!” Combining student-led community outreach with local culture. T. Block.
22.
ASBMB OPENING LECTURE: HERBERT TABOR RESEARCH AWARD Award Lecture Sat. 5:30 pm—McCormick Place Convention Center, W375C
5:30 ASBMB Business Meeting and Award Introduction. 5:45 22.1 Post-Transcriptional Regulation and the Bacterial Response to Stress. S. Gottesman. NCI, NIH.
23.
SCIENCE OUTREACH POSTER SESSION, CONTINUED Poster Discussion Sat. 6:30 pm—McCormick Place Convention Center, W375C
Outreach posters will be manned before and after the ASBMB Opening Lecture which takes place in the same room. Manning times: 4:00–5:15 pm and 6:30–7:00 pm. Refer to session 20 for presentation information.
24.
EB WELCOME RECEPTION Special Event Sat. 7:00 pm—McCormick Place Convention Center, W375DE
Join fellow attendees for our first-ever, inter-disciplinary meet and mingle and appreciate the power and energy of the EB Meeting! Light refreshments and cash bar available. Memberattendees receive one complimentary drink ticket when they sign up for the event during EB Meeting registration.
ASBMB BUSINESS MEETING Business Meeting Sat. 5:30 pm—McCormick Place Convention Center, W375C
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S A T
NUTRITION SATURDAY
Nutrition 26.
CONDUCTING A SYSTEMATIC REVIEW FOR A GLOBAL AUDIENCE: CHALLENGES IN MERGING NUTRITION AND TOXICOLOGICAL EVIDENCE FOR A SAFETY ASSESSMENT OF CAFFEINE Symposium (Sponsored by: ILSI North America) Sat. 8:30 am—McCormick Place Convention Center, S100BC Chaired: A. Kretser and D. Keefe
8:30
Welcome & Introduction. Alison Krestser. ILSI North America. 8:35 The Caffeine Landscape: Framing the Need for the Systematic Review. Dennis Keefe. US Food and Drug Administration. 8:45 Striving for the Gold Standard in the Systematic Review Process. Esther Myers. EF Myers Consulting. 9:10 The Methodology and Challenges of the Caffeine Systematic Review: An Expert Perspecive. Daniele Wikoff. ToxStrategies. 9:50 Discussion. 10:10 Break. 10:25 General Results of the Systematic Review. Daniele Wikoff. ToxStrategies. 10:35 Caffeine and Behavior. Harris Lieberman. US Army. 10:42 Caffeine and Behavior. Charles O’Brien. Univ. of Pennsylvania. 10:50 Caffeine and Reproductive & Developmental Toxicology. Jennifer Peck. Univ. of Oklahoma Health Sciences Ctr. 11:05 Caffeine & Cardiovascular Health. Daniele Wikoff. ToxStrategies. 11:20 Caffeine, Bone & Calcium. Connie Weaver. Purdue Univ. 11:35 Caffeine & Acute Toxicity & Pharmacokinetics. Milton Tenenbein. Univ. of Manitoba. 11:50 Panel Discussion with the Caffeine Systematic Review Project Team Members. Dennis Keefe.
27.
CLINICAL EMERGING LEADER AWARD ORAL COMPETITION Award Competition Sat. 9:00 am—McCormick Place Convention Center, S102BC Chaired: D. McCarron Clinical and Translational Nutrition
9:00
8
Daily Red Meat Intake Does Not Affect Improvements in Cardiovascular Disease Risk Factors Induced by Consuming the USDA’s Healthy MediterraneanStyle Eating Pattern. L.E. O’Connor, A.J. Wright, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. (966.9)
9:15
Bone Mineral Accretion Is Increased During Winter and Is Positively Related to Lean Mass Accretion and Calcium Intake in Healthy Children 2–8 y. N.R. Brett, C.A. Vanstone, H.A. Weiler. McGill University, Canada. (316.1) 9:30 The Impact of Avocado Fruit on Postprandial Satiety: An Acute Dose Response Study. Y. Huang, E. Park, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Institute for Food Safety and Health, Illinois Institute of Technology, University of California at Davis. (433.6) 9:45 Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. (447.3) 10:00 Dietary Cholesterol Lowers Risk of Type 2 Diabetes in the Framingham Offspring Study. M.M. Mott, M. Singer, M. Bradlee, L.L. Moore. Boston University School of Medicine. (167.3)
28.
POSTDOCTORAL RESEARCH AWARD COMPETITION Award Competition (Supported by DuPont Nutrition & Health) Sat. 9:30 am—McCormick Place Convention Center, S103BC Chaired: P.Y. Hsiao
9:30 9:40
Introductory Remarks. Diminished Citrulline-Arginine-Nitric Oxide Production Rates Are Associated with Necrotizing Enterocolitis Incidence in Premature Pigs. J.L. Robinson, V.A. Smith, S.M. Cruz, P.E. Lau, R. Manjarín, O.O. Olutoye, B. Stoll, J.C. Marini, D.G. Burrin. USDA/ ARS Children’s Nutrition Research Center, Baylor College of Medicine, California Polytechnic State University and Baylor College of Medicine. (164.1) 10:00 Plant-Based Diets and the Risk of Coronary Heart Disease in US Adults. A. Satija, S.N. Bhupathiraju, D. Spiegelman, S.E. Chiuve, J.E. Manson, W.C. Willett, K.M. Rexrode, E.B. Rimm, F.B. Hu. Harvard TH Chan School of Public Health, Brigham and Women’s Hospital and Brigham and Women’s Hospital. (167.4) 10:20 Oral Administration of Curcumin and Salsalate Attenuates High Fat Diet-Induced Up-Regulation of Pro-Inflammatory Colonic Cytokines and Suppresses Akt/NFκB Signaling in Azoxymethane-Treated Mice. X. Wu, A.C. Pfalzer, G. Koh, J.W. Crott, S. Tang, M.J. Thomas, M. Meydani, J.B. Mason. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Tufts Medical Center. (46.6)
SATURDAY NUTRITION 10:40 The Omega-6 to Omega-3 Fatty Acid Ratio Predicts Brain Activity During Planning Tasks in Middle Childhood. K. Sheppard, C.L. Cheatham. The Research Institute at Nationwide Children’s Hospital and University of North Carolina at Chapel Hill. (636.8) 11:00 Identification of Dietary Patterns Associated with Chronic Disease Risk Using Hybrid Dimension Reduction Techniques: Evidence from the Canadian National Nutrition Survey. M. Jessri, R.D. Wolfinger, W. Lou, M. L’Abbe. University of Toronto, Canada, North Carolina State University, University of North Carolina at Chapel Hill, Scientific Discovery and Genomics and SAS Institute. (314.4) 11:20 Transcriptome Analysis Reveals Persistent Effects of Neonatal Diet on Small Intestine Gene Expression Profile in a Porcine Model. M.K. Saraf, A.K. Bowlin, C. Chen, H. Dawson, T.M. Badger, V. Yeruva. Arkansas Children’s Nutrition Center, UAMS, USDAARS Human Nutrition Research Center and ACRI. (434.5) 11:40 Conclusion.
29.
CHILDHOOD NUTRITION EPIDEMIOLOGY Oral Sat. 10:30 am—McCormick Place Convention Center, S102D Chaired: J. Kaar and T. Crume
10:30 29.1 Dietary Intakes of the US Child and Adolescent Population and Their Adherence to the Current Dietary Guidelines: Trends from 1999 to 2012. X. Gu, K.L. Tucker. Brown University School of Public Health and University of Massachusetts Lowell. 10:45 29.2 Diet Quality Declines and Differs by Race in Early Childhood. K.A. Reynolds, H. Kalkwarf, S. Summer, P. Khoury, M. Gavin, J.G. Woo. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine. 11:00 29.3 Comparison of Fruit and Vegetable Intake from School and Packed Lunches: Intra-Individual Variation Across the School Week. J.C. Taylor, C. Sutter, L. Ontai, A. Nishina, S. Zidenberg-Cherr. University of California at Davis. 11:15 29.4 Association of Snacking Frequency with Patterning of Daily Energy Intake and Weight Among US Toddlers and Preschoolers. J.O. Fisher, A. Davey, A. Kachurak, R.K. Bailey. Temple University, University of Delaware and Purdue. 11:30 29.5 Snacking Characteristics and Patterns in the Childhood Obesity Prevention and Treatment Research Consortium. M.N. LeCroy, K.P. Truesdale, D. Matheson, A. Thomas, S. Moore, T. Robinson, S. French, J. Berge, S. Karp, H. Nicastro. University of North Carolina at Chapel Hill, Stanford University, Case Western Reserve University, University of Minnesota, Vanderbilt University, National Heart, Lung and and Blood Institute (NHLBI).
11:45 29.6 Macronutrient Composition of Early Childhood Diet Is Associated with Growth and Adiposity. T. Voortman, K.V. Braun, V.W. Jaddoe, O.H. Franco. Erasmus University Medical Center, Netherlands. 12:00 29.7 Protein Intake Is Associated with Lower Body Fat and Higher Skeletal Muscle Mass in Late Adolescence. M.M. Mott, M.R. Singer, M. Bradlee, S.R. Daniels, L.L. Moore. Boston University School of Medicine and University of Colorado School of Medicine.
30.
POLICY, SYSTEMS AND ENVIRONMENTAL APPROACHES IN PUBLIC HEALTH NUTRITION Oral Sat. 10:30 am—McCormick Place Convention Center, S103A Chaired: L. Sibeko and K. Hongu
10:30 30.1 Nutrition Facts Use by Young Adults: Predictors, Information Sought, and Relation to Dietary Intake. M.J. Christoph, N.I. Larson, M.N. Laska, D. NeumarkSztainer. University of Minnesota. 10:45 30.2 Identifying Feasible Ways for Cafeteria Operators to Comply With Calorie and Sodium Nutrition Standards in Hospitals. S. Lee-Kwan, S. Onufrak, C. Simon. Centers for Disease Control and Prevention and Partnership for a Healthier America. 11:00 30.3 Attitudes of SNAP-Approved Store Owners and Managers Regarding the Proposed USDA Rule to Strengthen Stocking Standards: A Qualitative Study in San Francisco and Oakland, California. C.W. Leung, I.H. Yen, B.A. Laraia, J.M. Tester. University of California, San Francisco, University of California, Berkeley, University of California, San Francisco and Benioff Children’s Hospital Oakland. 11:15 30.4 Impact of a Multi-Level Multi-Component Food Environment/Behavioral Intervention on Youth Leaders. A. Trude, E. Anderson Steeves, C. Shipley, P.M. Sato, L. Lachenmayr, J. Gittelsohn. Johns Hopkins University, University of Tennessee, Federal University of Sao Paulo, Brazil and Food Supplement Nutrition Education (FSNE). 11:30 30.5 Using the Wilder Collaboration Factors Inventory to Assess SNAP-Ed Coalitions in Arizona: Results from Four Counties. L. McCullough, L. Jacobs, K. Orzech, V. Farrell, D. McDonald, T. Armstrong Florian, P. Zilliox, C. Martinez, S. Misner. University of Arizona. 11:45 30.6 Development of a Healthy Eating Pattern for the Revision of Canada’s Food Guide. L. Elvidge, K. Davis, K.A. Esslinger, S. St-Pierre. Health Canada, Canada. 12:00 30.7 Does the Recent Chilean Regulation on Food Labelling Improve Chilean Population Knowledge on Nutritional Facts? A Longitudinal Comparison Between 2012 and 2016. D. Gregori, C.E. Gafare, G. Lorenzoni. University of Padova, Italy and University of Buenos Aires, Argentina. 12:15 30.8 Barriers to Healthcare Seeking and Provision Among African American Adults in the Rural Mississippi Delta: Community and Provider Perspectives. C. Connell, K. Yadrick, S. Wang. The University of Southern Mississippi and Santa Clara University.
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S A T
NUTRITION SATURDAY
31.
OBESITY AND THE METABOLIC SYNDROME Oral Sat. 10:30 am—McCormick Place Convention Center, S103D Chaired: B. Piccolo
10:30 31.1 Neonatal Nutrition Affects Adolescent Insulin Sensitivity and the Lineage Allocation of Bone Marrow Derived Mesenchymal Stem Cells in Ossabaw Pigs. W. Zhang, R. Murray, C. Stahl. University of Maryland. 10:45 31.2 E4orf1 Protein Requires the Distal but Not Proximal Insulin Signaling to Enhance Glut4 Translocation. A. Shastri, S. Peddibhotla, Z. Feizy, V. Hegde, N.V. Dhurandhar. Texas Tech University. 11:00 31.3 Weight Loss via Alternate Day Fasting Increases Circulating Endogenous Secretory RAGE and Is Associated with Markers of Adipocyte Health. E.R. Miranda, K. Varady, J.M. Haus. UIC. 11:15 31.4 High-Sucrose Diet Time-Dependently Changes Hepatic Endoplasmic Reticulum Stress from an Adaptive to Pro-Apoptotic Pattern in Young Mice. A. ‘de Andrade Paes, K.T. Flister, P.C. dos Santos, B.A. Pinto, C.C. Vale, D. Kajihara, F.M. Laurindo, L.M. França. Federal University of Maranhão, Brazil and Heart Institute of the School of Medicine of University of São Paulo, Brazil. 11:30 31.5 Cardiometabolic Status in Obese African American Women Is Linked to Glycative Stress. S.A. Nance, A.V. Duncan, K.G. Hairston, T.M. Gwathmey. Wake Forest University School of Medicine. 11:45 31.6 A Randomized Clinical Trial in Women with Polycystic Ovary Syndrome: Effects of a Pulse-Based Diet and Exercise Intervention on Blood Lipids, Body Composition and Reproductive Measures. L.E. McBreairty, M. Kazemi, J.J. Gordon, R.A. Pierson, D.R. Chizen, P.D. Chilibeck, G.A. Zello. University of Saskatchewan, Canada. 12:15 31.7 Evenly Re-Distributing Daily Dietary Protein Intake Does Not Augment Changes in Body Composition and Cardio-Metabolic Health Indexes. J.L. Hudson, J. Kim, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. 12:30 31.8 Characterization of Spontaneous Severe Hypertriglyceridemia in Diabetic Nonhuman Primates. B.C. Hansen, J.D. Newcomb, U.C. Chaudhari. University of South Florida.
10
32.
BIOAVAILABILITY AND METABOLISM OF CAROTENOIDS AND VITAMIN A Oral Sat. 10:30 am—McCormick Place Convention Center, S104B Chaired: J. Cooperstone and E. Mohn
10:30 Chair Introduction. 10:45 32.1 Increased Study Length of Retinol Isotope Dilution with Compartmental Modeling Alters Kinetic Parameters and Calculated Vitamin A Stores. B.M. Gannon, A.R. Valentine, C.R. Davis, J.A. Howe, S.A. Tanumihardjo. University of Wisconsin-Madison, Cornell University, Oregon Health & Science University and Auburn University. 11:00 32.2 Dietary Vitamin A Dose Dependently Regulates BMP4 and WNT7A in Hair Follicles. H.B. Everts, J. Reu, J.P. Sundberg, L. Suo. Texas Woman’s University, The Ohio State University and The Jackson Laboratory. 11:15 32.3 Vitamin A Supplementation Redirects the Flow of Retinyl Esters from Peripheral to Central Organs in Neonatal Rats Raised Under Vitamin A-Marginal Conditions. J.K. Hodges, L. Tan, M.H. Green, A. Ross. Pennsylvania State University and University of Alabama. 11:30 32.4 Nutritional Changes During Biofortified Maize Fermentation (Steeping) for Ogi Production. D. Ortiz, S. Nkhata, A. Buechler, T. Rocheford, M.G. Ferruzzi. Purdue University and North Carolina State University. 13 11:45 32.5 C β-Carotene Stability During Digestion in Healthy Humans. R.E. Kopec, C. Caris-Veyrat, M. Nowicki, B. Gleize, C. Desmarchelier, P. Borel. INRA/ University of Avignon—UMR 408, France, The Ohio State University and UMR 1260 INRA/1062 INSERM/Aix-Marseille University, France. 12:00 32.6 Dose-Response Effects of Soybean Oil in Salad Dressing Upon the Bioavailability of Carotenoids/FatSoluble Vitamins in Salad Vegetables. W.S. White, Y. Zhou, A. Crane, P. Dixon, F. Quadt, L.M. Flendrig. Iowa State University, Quadt Consultancy BV, Netherlands and Unilever R&D Vlaardingen, Netherlands. 12:15 32.7 A Comparison of Lutein Bioaccumulation in Infant Rhesus Macaques Fed Breast Milk, CarotenoidSupplemented Formula, or Unsupplemented Formula. S. Jeon, K.M. Ranard, M. Neuringer, E.E. Johnson, L. Renner, M. Kuchan, S.L. Pereira, E.J. Johnson, J.W. Erdman; Jr. University of Illinois at Urbana-Champaign, Oregon Health & Science University, Abbott Nutrition and Tufts University.
SATURDAY NUTRITION
33.
YOUNG MINORITY INVESTIGATOR ORAL COMPETITION
(Supported by DSM Nutritional Products)
Do Low/No-calorie Sweeteners Help or Hurt Appetite and Weight Management? Peter Rogers. Univ. of Bristol. 12:00 Low/No-Calorie Sweeteners Influence on Gut Microbiota and Interactions of Microbiota with Stevia. Ian Rowland. Univ. of Reading.
(Sponsored by: ASN Minority and Diversity Affairs Committee)
35.
Award Competition
Sat. 11:00 am—McCormick Place Convention Center, S102BC
INFORMING B-24 DIETARY GUIDELINES: FINDINGS FROM THE NEW FEEDING INFANTS AND TODDLERS STUDY 2016
Chaired: M.D. Teran-Garcia
Symposium
11:00 The Aryl Hydrocarbon Receptor is a Repressor of Colorectal Cancer Development Induced by High-fat Diet in Mice. E.J. Garcia-Villatoro, L. Davidson, E. Callaway, K. Allred, M. Hensel, A. Jayaraman, S. Safe, R. Chapkin, C.D. Allred. Texas A&M Univ. 11:15 Toddler Formulas: Nutritional Value and Marketing Claims. M.J. Romo Palafox, J.L. Harris. Univ. of Connecticut. 11:30 Effect of a Mindful Eating Intervention on Biomarkers of Prognosis and Survival in Overweight and Obese Postmenopausal Breast Cancer Survivors: A Translational Pilot Study. A.M. Washington, M. Davis, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, B.D. Jenkins, E.L. Sattler. Univ. of Georgia. 11:45 Loss of a Healthy Weight Advantage among Foreignborn Children of Mexican Origin: An Analysis of Overweight/Obesity Trends from 1988–1994 to 2007–2014. L.E. Maldonado, S.S. Albrecht. Univ. of North Carolina at Chapel Hill. 12:00 Validity and Reliability of a Nutrition Knowledge Questionnaire for Adolescents. L.D. Ruiz, A.M. Jones, R.E. Scherr. Univ. of California at Davis. 12:15 Mechanisms Mediating Effects of Eicosapentanoic Acid in Hepatic Steatosis in High Fat Fed Mice and in HepG2 Hepatoma Cells. S.M. Gonzalez, K.M. AlbrachtSchulte, L. Ramalingam, N.S. Kalupahana, N. Moustaid-Moussa. Texas Tech Univ.
34.
12:00
STEVIA LEAF TO STEVIA SWEETENER: EXPLORING ITS SCIENCE, BENEFITS AND FUTURE POTENTIAL ASN Satellite Sat. 12:00 pm—McCormick Place Convention Center, S105BCD Chaired: P. Samuel and K. Ayoob
12:00 Introduction: A Historical Perspective on the Development of Stevia as a Sweetener. Keith Ayoob. Albert Einstein Col. of Med. 12:00 The Metabolic Fate and Safety of Stevia Leaf Extract. Berna Magnuson. Health Science Consultants. 12:00 Stevia’s Impact on Blood Glucose, Diabetes and Health. Per Bendix Jeppesen. Univ. of Aarhus. 12:00 The Naturality and Processing of Stevia Leaf Extract and Emerging New Innovations. Ursula WölwerRieck. Univ. of Bonn.
Sat. 12:30 pm—McCormick Place Convention Center, S100A 12:30 FITS 2016: An Overview of Study Design and Methodology. Andrea Anater. RTI International. 12:40 FITS 2016: An Overview of Study Design and Methodology. Diane Catellier. RTI International. 12:50 The Usual Nutrient Intakes of Infants, Toddlers and Preschoolers in the USA in 2016. Regan Bailey. Purdue Univ. 1:15 The Food Intake Patterns of Infant and Toddlers in the USA in 2016. William Dietz. George Washington Univ. 1:40 The Food Intake Patterns of Preschoolers in the USA in 2016. Mary Story. Duke Global Health Inst. 2:05 Dietary Intake Behaviors Among Infants, Toddlers, and Preschoolers Participating in the WIC Program. Joanne Guthrie. USDA ERS.
36.
GRADUATE STUDENT RESEARCH AWARD COMPETITION Award Competition Sat. 12:30 pm—McCormick Place Convention Center, S103BC Chaired: S. Adams
12:30 Dietary Depletion of Bovine Milk Exosomes Elicits Changes in Amino Acid Metabolism in C57BL/6 Mice. A.L. Leiferman, A. Aguilar, E. Mutai, J. Adamec, J. Zempleni. University of Nebraska. (135.3) 12:45 Regulation of Endogenous Dusp4 by AgonistSpecific MAPK Activation in Adipocytes. W. Guo, B.S. Ferguson, R.F. Morrison. University of North Carolina Greensboro. (644.20) 1:00 Myeloid Derived Suppressor Cells (MDSC) Are Vitamin D Targets and 1α, 25 Dihydroxyvitamin D (1,25(OH)2d) Inhibits Their Ability to Suppress T Cell Function. R.D. Calvert, G.N. Burcham, T.L. Ratliff, J.C. Fleet. Purdue University and Southern Indiana Purdue Agricultural Center. (434.8) 1:15 Vitamin E δ-Tocotrienol Inhibits NF-κB Activation by Up-Regulating A20 in Macrophages and Suppresses Colitis-Promoted Colon Tumorigenesis in Mice. C. Yang, Q. Jiang. Purdue University. (135.2) 1:30 Absorption and Excretion of Vitamin K Varies by Age and Triglycerides: A Metabolic Study in Older and Younger Adults Using Deuterium-Labeled Collard Greens. J.L. Ellis, X. Fu, A. Al Rajabi, E.N. Naumova, M.A. Grusak, E. Saltzman, S.L. Booth. Tufts University and Baylor College of Medicine. (148.3)
11
S A T
NUTRITION SATURDAY 1:45 Docosahexaenoic Acid Is More Effective Than Eicosapentaenoic Acid in Increasing the Omega-3 Index Measured in Red Blood Cell Membranes. J. Allaire, W. Harris, C. Vors, A. Tchernof, P. Couture, B. Lamarche. Institute of Nutrition and Functional Foods, Laval University, Canada, Sanford School of Medicine, University of South Dakota School of Medicine, OmegaQuant, University Institute of Cardiology and Pneumology, Canada, CHU de Québec Research Center and Laval University, Canada. (146.3) 2:00 Insulin Resistance Is Inversely Associated with the Intestinal Expression of Key Genes Involved in Chylomicron Assembly and Secretion. J. DrouinChartier, A.J. Tremblay, V. Lemelin, M. Lépine, V. Guay, B. Lamarche, P. Couture. Laval University, Canada. (137.6) 2:15 Neonatal Iron Status at Birth Is Independently Regulated by Fetally Derived Hepcidin in Neonates Born to Women Carrying Multiple Fetuses. Y. Ru, E.K. Pressman, R. Guillet, E.M. Copper, P.J. Katzman, K.O. O’Brien. Cornell University and University of Rochester Medical Center. (316.3) 2:30 Effects of Saturated Fatty Acids from Butter and Cheese on High-Density Lipoprotein (HDL)Mediated Cholesterol Efflux Capacity. D. Brassard, B. Arsenault, M. Boyer, D. Bernic, M. TessierGrenier, A. Tremblay, P. Jones, E. Levy, P. Couture, B. Lamarche. Institute of Nutrition and Functional Foods (INAF), Canada, Laval University, Canada, Québec Heart and Lung Institute, Canada, University of Manitoba, Canada, CHU Sainte-Justine Research Center, Canada and CHU de Quebec Research Center (CRCHUQ), Canada. (146.1) 2:45 Hemoglobin Response to 12 Weeks of Iron Supplementation Is Substantially Lower Among Non-Pregnant Cambodian Women with Genetic Hemoglobin Disorders. C.D. Karakochuk, M.K. Barker, S.I. Barr, S.M. Vercauteren, A.M. Devlin, K.C. Whitfield, K. Hou, K.B. Harding, L.M. De Regil, K. Kraemer, T.J. Green. University of British Columbia, Canada, BC Children’s Hospital Research Institute, Canada, BC Children’s Hospital, Canada, Mount Saint Vincent University, Canada, Helen Keller International, Cambodia, Micronutrient Initiative, Canada, Sight and Life Foundation, Switzerland and South Australian Health and Medical Research Institute, Australia. (43.5)
12
3:00
3:15
37.
Meta-Analysis of the Association of Omega-3 Fatty Acids Biomarkers with Pulmonary Function. J. Xu, T.M. Bartz, G. Eiriksdottir, A.C. Frazier-Wood, V. Gudnason, L. Lahousse, A. Manichaikul, R.R. Rohde, F. Sun, N. Terzikhan, X. Zhou, R.G. Barr, G.G. Brusselle, J. Dupuis, S.A. Gharib, S.J. London, K.E. North, B.M. Psaty, A.V. Smith, L.M. Steffen, D.B. Hancock, P.A. Cassano. Cornell University, University of Washington, Icelandic Heart Association, Iceland, Baylor College of Medicine, University of Iceland, Iceland, Ghent University, Belgium, Erasmus Medical Center, Netherlands, University of Virginia School of Medicine, University of North Carolina, Boston University School of Public Health, University of Minnesota, Columbia University, National Institute of Environmental Health Sciences, NIH, DHHS and RTI International. (167.5) Local Egg Production Centers Significantly Increase Maternal and Child Egg Consumption in Rural Zambia. S. Dumas, A.J. Travis. Cornell University. (455.7)
TRANSLATIONAL RESEARCH AWARD COMPETITION Award Competition (Sponsored by: Nutrition Translation RIS) Sat. 1:00 pm—McCormick Place Convention Center, S102BC Chaired: M. Braun
1:00 Introduction. 1:15 Stem-Like Cells in Breastmilk for Hospitalized Preterm Infants. C. Briere, T. Jensen, J.M. McGrath, C. Finck. Connecticut Children’s Medical Center, University of Connecticut and University of Connecticut Health Center. (650.33) 1:30 Salt and the City: A Preliminary Examination of New York City’s Sodium Warning Labels. S. Downs, M. Bloem, M.M. Graziose. Johns Hopkins University, Wageningen University, Netherlands and Columbia University. (302.2) 1:45 Nutrition Facts Use by Young Adults: Predictors, Information Sought, and Relation to Dietary Intake. M.J. Christoph, N.I. Larson, M.N. Laska, D. Neumark-Sztainer. University of Minnesota. (30.1) 2:00 Iron in Micronutrient Powder (MNP) May Adversely Affect the Gut Microbiome in Kenyan Infants. M. Tang, D.N. Frank, A.E. Hendricks, D.L. Culbertson, F. Esamai, N.F. Krebs. University of Colorado Anschutz Medical Campus, University of Colorado Denver, Washington University in St. Louis and Moi University School of Medicine, Kenya. (965.26) 2:15 Foodomics Application: Analysis of Dietary Components of the DASH Diet Pre and Post Consumption. Y. Nkrumah-Elie, R. Reisdorph, B. Tooker, M. Tang, L. O’Connor, S. Borengasser, R. Sayer, N. Krebs, W. Campbell, N. Reisdorph. University of Colorado, Anschutz Medical Campus and Purdue University. (437.6)
SATURDAY NUTRITION
38.
39.
PHENHRIG 2017: PLANT PHENOLICS ALTER MICROBIOME AND HUMAN HEALTH
Oral
Sat. 1:00 pm—McCormick Place Convention Center, S103A
Sat. 3:00 pm—McCormick Place Convention Center, S102BC
Chaired: T. Wilson
Chaired: M. Panasevich and T-W. Liu
ASN-NNEDPRO NUTRITION EDUCATORS DISCUSSION AND NETWORKING EVENT: TRAIN NUTRITION TRAINERS
(Supported by Abbott Nutrition) Sat. 1:00 pm—Hilton Chicago, Williford A
THE CHANGING BRAIN: HOW BRAIN PLASTICITY, EXERCISE, AND NUTRITION AFFECT FUNCTION AND COGNITION Symposium (Supported by Abbott Nutrition) Sat. 3:00 pm—McCormick Place Convention Center, S100BC
3:00 3:30 4:00 4:30
41.
Neurogenesis and Brain Plasticity in the Adult Brain. Henriette van Praag. National Inst. of Aging. The Relation of Exercise, Fitness and Adiposity to Cognitive and Brain Health. Charles Hillman. Univ. of Illinois at Urbana-Champaign. Exercise, Nutrition and Brain Function: What are the Steps Toward Dietary Recommendations? Mary Ann Johnson. Univ. of Georgia. Neuroinflammatory Processes in Cognitive Disorders: Is There a Role for Nutrients in Counteracting their Detrimental Effects? Sophie Laye. Universite Bordeaux.
ROBERT SUSKIND AND LESLIE LEWINTERSUSKIND PEDIATRIC NUTRITION LIFETIME ACHIEVEMENT AWARD Award Lecture Sat. 3:00 pm—McCormick Place Convention Center, S100A
3:00 3:40
METABOLIC PHENOTYPING, METABOLOMICS AND BIOMARKERS
Special Session
Special Session
40.
42.
3:00 42.1 Metabolomics of Coffee Consumption. M. Cornelis, I. Erlund, C. Herder, J.A. Westerhuis, J. Tuomilehto. Northwestern Feinberg School of Medicine, National Institute for Health and Welfare, Finland, Institute for Clinical Diabetology, German Diabetes Center, Germany, Swammerdam Institute for Life Sciences, University of Amsterdam, Netherlands, Department of Public Health and University of Helsinki, Finland. 3:15 42.2 Combined Metabolomic and Fluxomic Assays Suggest the Existence of Multiple Pools of Glucose6-Phosphate in Perfused Muscle. S. Previs, K. Herath, A. Petrov, J. Castro-Perez. Merck. 3:30 42.3 Serum Branched Chain and Aromatic Amino Acids Are Associated to Overweight, Obesity and Metabolic Alterations in School-Aged Children. E. Ocampo-Medina, S. Moran-Ramos, L. Macias-Kauffer, B.E. Lopez-Contreras, H. Villamil-Ramirez, P. Leon-Mimila, R. Villarruel-Vazquez, I. Ibarra-Gonzalez, M. Vela-Amieva, S. Canizales-Quinteros. National Institute of Genomic Medicine, Mexico, CONACYT, Mexico, Institute of Biomedical Research, UNAM, Mexico, National Institute of Pediatrics, Mexico, School of Chemistry and UNAM, Mexico. 3:45 42.4 Incorporation of Dietary n-3 Fatty Acids Into Selective Phosphatidylcholine Lipids in Human Plasma After Salmon Intake. P. Zacek, M. Bukowski, S. Raatz, M. Picklo. USDA ARS GFHNRC. 4:00 42.5 A Shotgun Fingerprinting Approach to Document Compliance with an Almond Consumption Intervention. J. Dhillon, C.R. Ferreira, T.J. Sobreira, R.D. Mattes. Purdue University. 4:15 42.6 Plasma Fatty Acids Patterns and Hyperlipidemia: A Prospective Study. Y. Gao, J. Zhao. Chinese Academy of Science, People’s Republic of China. 4:30 42.7 Metabolomics and Lipidomics Analysis of the NIA CALERIE Trial. B.S. Kristal, R.M. Gathungu, S.S. Bird, V.R. Marur, M.J. Sniatynski, D.P. Sheldon, C. ‘CALERIE ‘Clinical Trial Consortium. Brigham and Women’s Hospital/ Harvard Medical School and Various. 4:45 42.8 Effect of Dietary Coconut Oil and Conjugated Linoleic Acid on Liver Metabolic Phenotype in Mice. K.M. Barnes, J.P. Engle, Q. Chen, A.M. DiGregorio, J.W. McFadden. West Virginia University.
Nancy F. Krebs. Univ. of Colorado Kenneth H. Brown. Bill and Melinda Gates Foundation.
13
S A T
NUTRITION SATURDAY
43.
MEASURING AND IMPROVING MICRONUTRIENT STATUS Oral (Sponsored by: Global Nutrition Council) Sat. 3:00 pm—McCormick Place Convention Center, S102D Chaired: R. Engle-Stone and A. Palmer
3:00 43.1 Effect of the Provision of a Macro- And MicroNutrient Fortified Complementary Food Supplement on Nutritional Status of Ghanaian Infants. S. Ghosh, N. Strutt, G.E. Otoo, D.J. Suri, J. Ankrah, T. Johnson, P. Nsiah, C. Furuta, H. Murakami, G. Perera, K.K. Chui, K. Bomfeh, H.A. Kuofi, K.T. Debrah, R. Uauy. NS INF, Tufts, University of Ghana, Ghana, University of Cape Coast, Ghana, Ajinomoto Inc, Japan and INTA, Chile. 3:15 43.2 Evaluating Iron Metabolism and Supplementation in Gambian Toddlers Using a Novel, HighPrecision Method Based on the Dilution of Labelled Body Iron. D. Moretti, R. Wegmüller, C. Speich, C. Zeder, M. Cichucka, C.I. Cercamondi, A.M. Prentice, G. Brittenham, M.B. Zimmermann. ETH Zürich, Switzerland, MRC Unit, The Gambia, LSHTM, UK, Columbia University Medical Center. 3:30 43.3 Maternal Vitamin D Supplementation Significantly Improved Maternal Plasma 25(OH)D but Not Infant 25(OH)D or Bone Turnover Markers in Ethiopian Lactating Women and Their Infants. M. Girma, B. Tilahun, B. Mulugeta, F. Reta, B.J. Stoecker. Oklahoma State University and Hawassa University, Ethiopia. 3:45 43.4 Differences in Hepcidin Concentrations by Sickle Cell and α+-Thalassemia Genotype: A Cross-Sectional Study Nested Within the Kenya WASH Benefits Trial. K. Byrd, G. Rao, A. Lin, C.D. Arnold, M. Kiprotich, H.N. Dentz, T.N. Williams, A. Pickering, A.C. Null, C.P. Stewart. University of California, Davis, Innovations for Poverty Action, University of California, Berkley, Imperial College, UK, Stanford University. 4:00 43.5 Hemoglobin Response to 12 Weeks of Iron Supplementation Is Substantially Lower Among Non-Pregnant Cambodian Women with Genetic Hemoglobin Disorders. C.D. Karakochuk, M.K. Barker, S.I. Barr, S.M. Vercauteren, A.M. Devlin, K.C. Whitfield, K. Hou, K.B. Harding, L.M. De Regil, K. Kraemer,T.J. Green. University of British Columbia, Canada, BC Children’s Hospital Research Institute, Canada, BC Children’s Hospital, Canada, Mount Saint Vincent University, Canada, Helen Keller International, Cambodia, Micronutrient Initiative, Canada, Sight and Life Foundation, Switzerland and South Australian Health and Medical Research Institute, Australia. 4:15 43.6 Delaying Iron Therapy by 28 Days Is Associated with Improved Long-Term Iron Status and Equivalent Hemoglobin in Children with Severe Malaria and Iron Deficiency. S.E. Cusick, R.O. Opoka, P. Bangirana, A. Ssemata, M.K. Georgieff, C.C. John. University of Minnesota, Makerere University, Uganda and Indiana University.
14
4:30 43.7 Effects of a Micronutrient Powder Containing Low-Dose Iron and Galacto-Oligosaccharides on the Gut Microbiome and Iron Absorption: A Stable Iron Isotope Study and a Randomized Controlled Trial in Kenyan Infants. D. Paganini, M. Uyoga, C. Cercamondi, D. Moretti, C. Lacroix, S. Karanja, M.B. Zimmermann. Swiss Federal Institute of Technology, Switzerland, Jomo Kenyatta University of Agriculture and Technology, Kenya. 4:45 786.17 Impact of Provitamin A Biofortified Maize Consumption on Carotenoid Status of Zambian Children. N.E. Craft, A. Palmer, K. Schulze, J. Chileshe, M. Barffour, W. Siamusantu, R. Klemm, K. West. Craft Technologies, Inc., Johns Hopkins Bloomberg School of Public Health, Tropical Diseases Research Centre, Zambia, and National Food and Nutrition Commission, Zambia.
44.
OBESITY: ADIPOSE TISSUES AND MUSCLE METABOLISM Oral Sat. 3:00 pm—McCormick Place Convention Center, S103D Chaired: J. Alvarez
3:00 44.1 Obesity Is Associated with Increased Expression of Very Low Density Lipoprotein Receptor in Adipose Tissue: A Possible Link to Increased VLDL Catabolism and Adiposity. T. Hajri, B. Johnson, T. Talishinskiy, G. Mazpule, D. Ewing, S. Eld, R. Novack Jr, H. Schmidt. Hackensack University Medical Center. 3:15 44.2 Lipocalin-2 Is Required for Retinoic AcidInduced Beiging of White Adipocytes and Insulin-Stimulated Plasma Membrane Localization of RAR-α. J. Deis, H. Guo, D. Bernlohr, X. Chen. University of Minnesota. 3:30 44.3 Nanoparticles Encapsulated with Resveratrol Induce Browning of White Adipocytes. H. Overby, Y. Zu, S. Wang, L. Zhao. University of Tennessee Knoxville and Texas Tech University. 3:45 44.4 Regulation of Inducible Brown-Like Phenotype by Dietary 18-Carbon Fatty Acids in Mouse Adipocytes. S. Shin, K. Ajuwon. Purdue University. 4:00 44.5 Prenatal Iron Deficiency Causes Long-Term Alterations in Brown Adipose Tissue Quantity and Thermogenic Capacity in Adult Rats. S.L. Bourque, S.J. Cherak, J. Yoo, P.A. Johnson, A.G. Woodman, S. Panahi, F. Gragasin. University of Alberta, Canada. 4:15 44.6 UCP1-Null Mice Display Increased Susceptibility to Ovariectomy-Associated Metabolic Dysfunction. S.L. Clookey, R.J. Welly, T.M. Zidon, M.L. Gastecki, Z.I. Grunewald, N.C. Winn, N.G. Karasseva, H.S. Sacks, J. Padilla, V.J. Vieira-Potter. University of Missouri and UCLA David Geffen School of Medicine. 4:30 44.7 Raspberry Intake Reduces Skeletal Muscle Lipid Accumulation and Improves Insulin Sensitivity in Mice Fed High Fat Diet. M. Du, T. Zou, B. Wang, X. Liang, M. Zhu. Washington State University. 4:45 44.8 Protein-Dense Whole Food Ingestion Augments Postprandial Mitochondrial Protein Synthesis in Healthy-Weight, Overweight, and Obese Young Adults. J.W. Beals, S. van Vliet, R.A. Sukiennik, J.R. Young, A.C. Dilger, A.V. Ulanov, Z. Li, P.A. Scott, N.A. Burd. University of Illinois at Champaign-Urbana and University of Illinois.
SATURDAY NUTRITION
45.
FOOD ENVIRONMENT Oral Sat. 3:00 pm—McCormick Place Convention Center, S104A Chaired: J. Nelson-Peterman and S.A. Stotz
3:00 45.1 Healthy Food Availability and Marketing in San Francisco Small Food Stores—Differences by SNAP Vendor Status. C.W. Leung, B.A. Laraia, J.M. Tester, I.H. Yen. University of California at San Francisco, University of California at Berkeley, and University of California at San Francisco Benioff Children’s Hospital Oakland. 3:15 45.2 Analysis of Food Advertising in Children’s TV Programming. E.L. Cosenza, A. Morales-Juárez, M.F. Kroker-Lobos, S. Vandevijvere, M. Ramirez-Zea. Institute of Nutrition of Central America and Panamá (INCAP), Guatemala and University of Auckland, New Zealand. 3:30 45.3 Nutrient Declarations and Nutritional Quality of Processed and Ultra-Processed Foods Sold in Guatemala. A. Alarcon-Calderon, F. Kroker-Lobos, S. Vandevijvere, M. Ramirez-Zea. Institute of Nutrition of Central America and Panamá, Guatemala and University of Auckland, New Zealand. 3:45 45.4 Are Diets with a Lower Carbon Footprint More Nutritious? Evidence in the United States from the National Health and Nutrition Examination Survey. D. Rose, A. WillitsSmith, M. Heller, R. Meyer. Tulane University and University of Michigan. 4:00 45.5 Should the Definition of Food Deserts Incorporate a Seasonal Component? A.F. DarrouzetNardi, R.L. Boehm, S.E. Stabley. Allegheny College and Tufts University. 4:15 45.6 The Latino Tienda as Food Oasis Not Food Desert. S.M. Palmer, D.M. Winham, J.L. Baier, T.A. Roe. Iowa State University. 4:30 45.7 Disparities in Healthy Food Access: Are We Improving? R. DeWeese, P. Ohri-Vachaspati. Arizona State University. 4:45 45.8 Nutrition Resilience in the Seattle Obesity Study: How to Eat Better for Less. A. Aggarwal, J.A C. Delaney, A. Drewnowski. School of Public Health and University of Washington.
3:30 46.3 Withdrawn. 3:45 46.4 Dietary Genistein Inhibits MethylglyoxalInduced Advanced Glycation End Products Formation in HighFat Diet-Fed Mice. Y. Zhao, P. Wang, S. Sang. North Carolina A&T State University. 4:00 46.5 Effects of Lactobacillus paracasei N1115 on Intestinal Microbiota and Serum Lipid of Dyslipidemias. S. Tan, A. Zhao, Y. Zheng, P. Wang, Y. Zhang. Peking University, People’s Republic of China. 4:15 46.6 Oral Administration of Curcumin and Salsalate Attenuates High Fat Diet-Induced Up-Regulation of ProInflammatory Colonic Cytokines and Suppresses Akt/NFκB Signaling in Azoxymethane-Treated Mice. X. Wu, A.C. Pfalzer, G. Koh, J.W. Crott, S. Tang, M.J. Thomas, M. Meydani, J.B. Mason. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Tufts Medical Center. 4:30 46.7 Dietary Avicularin Alleviated Type 2 Diabetes in Mice. X. Zhu, W. Ouyang, J. Miao, P. Xiong, K. Feng, M. Li, Y. Cao, H. Xiao. South China Agricultural University, People’s Republic of China, and University of Massachusetts. 4:45 46.8 Mixture of Oleanolic Acid and Ursolic Acid Mimicked the Effects of Fructus ligustri lucidi on Calcium Kinetics, Bone Properties, and Serum 1,25(OH)2D3 in Ovariectomized Rats. M. Wong, S. Cao, M.E. Wastney, P.J. Lachcik, C. Weaver. The Hong Kong Polytechnic University, Hong Kong and Purdue University.
47.
Forum Sat. 3:30 pm—McCormick Place Convention Center, S106 Chaired: S. Mayne
48.
(Supported by The Coca-Cola Company) Sat. 5:00 pm—McCormick Place Convention Center, Hall F
EFFECTS OF DIETARY BIOACTIVE COMPONENTS IN EXPERIMENTAL MODELS OF CHRONIC DISEASE RISK Oral Sat. 3:00 pm—McCormick Place Convention Center, S104B
3:00 46.1 Eucalyptol Inhibits Diabetes-Associated Renal Fibrosis Through Blocking Epithelial to Mesenchymal Transition in Tubular Epithelial Cells Under High Glucose Stimulation. D. Kim, M. Kang, Y. Kang. Hallym University, Republic of Korea. 3:15 46.2 Seven Day Blackberry Feeding Lowers the Respiratory Quotient in Males and Improves Insulin Sensitivity. P. Solverson, W. Rumpler, J.L. Leger, B. Redan, M.G. Ferruzzi, D.J. Baer, J.A. Novotny. USDA, University of Maryland, Purdue University and North Carolina State University.
EMERGING LEADER POSTER COMPETITION Poster Award Competition
5:00
46.
COMPELLING CONVERSATIONS: FDA UPDATE ON NUTRITION INITIATIVES
5:00
Daily Red Meat Intake Does Not Affect Improvements in Cardiovascular Disease Risk Factors Induced by Consuming the USDA’s Healthy MediterraneanStyle Eating Pattern. L.E. O’Connor, A.J. Wright, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. (966.9) Ten Weeks of Protein Consumption at the RDA Results in a Loss of Appendicular Lean Mass in Healthy Older Men, a Randomized Controlled Trial. C.J. Mitchell, A.M. Milan, S.M. Mitchell, N. Zeng, F. Ramzan, P. Sharma, S. Knowles, N. Roy, A. Sjödin, K. Wagner, D. Cameron-Smith. University of Auckland, New Zealand, AgResearch, New Zealand, Copenhagen University, Denmark and University of Vienna, Austria. (139.1)
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NUTRITION SATURDAY 5:00
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5:00
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Identification of p-Cresol Sulfate and Secondary Bile Salts in Human Urine as Sensitive Biomarkers of Fecal Microbiota Transplantation in R-CDI Patients. Z. Bi, Y. Lu, A.R. Weigarden, D. Yao, L. Wang, A. Khoruts, M.J. Sadowsky, A. Khoruts, C. Chen. University of Minnesota. (315.1) Prefrontal Cortex Structure Mediates the Relationship Between Plasma Phospholipid Stearidonic Acid and Fluid Intelligence in Healthy, Older Adults. M.K. Zamroziewicz, E.J. Paul, C.E. Zwilling, T. Das, S. Pereira, A.K. Barbey. University of Illinois UrbanaChampaign and Abbott Nutrition. (460.1) Genistein in Combination with Fructooligosaccharides Prevents Bone Loss in Ovariectomized Rats. S. Pourafshar, N. Navaei, S.A. Johnson, S.C. Chai, S. Hooshmand, B.H. Arjmandi. Florida State University, Center for Advancing Exercise & Nutrition Research on Aging, Florida State University, Colorado State University, University of Delaware and San Diego State University. (645.9) Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. (447.3) A Year-Long Trial to Examine the Effects of a Daily Dose of Walnuts on Cardiometabolic Risk Markers in an Elderly Population. A. Al Abdrabalnabi, E. Bitok, S. Rajaram, N. Rizzo, J. Sabaté. Loma Linda University. (447.1) The Association Among Vitamin D Status, Bone Geometry and Muscle Structure in 14 to 18 y Female Adolescents with Usual Intake of Resume) & In Person. A. Green. Univ. of California, Berkeley. 10:30 Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Position. B. Lindstaedt. UCSF. 10:30 But I have no Skills! Exploring Myths & Career Options for PhDs. J. Lombardo. Med. Col. of Wisconsin and Marquette Univ. 1:00 How to Choose Your Ideal Career. B. Lindstaedt. UCSF. 1:00 Talking About Yourself: How to Interview Well. N. Saul. UCSF. 1:00 Navigating Doctoral Work Protocols/Milestones/ Requirements. H. Adams. H.G. Adams & Assoc., Norfolk, VA. 2:30 Selling Yourself to the Life Sciences Industry. J. Tringali. Tringali & Associates, Inc., Manchester, NH. 3:00 Global Interview Skills: A Practice Workshop for International Candidates. D. Behrens. Univ. of California, Berkeley. 3:00 The Strategic Postdoc: How to Find & Leverage Your Postdoc Experience. A. Green. Univ. of California, Berkeley.
TUESDAY ANATOMY
Anatomy
Chaired: H. Adesnik
9:00 386.2 Network Models: Connecting Anatomy to Systems Biology. B. Esteve-Altava. Royal Veterinary College, United Kingdom and Howard University College of Medicine. 9:30 386.3 Diversity of the Primate Musculoskeletal System: Modularity, Integration, and Anatomical Variation in Humans and Their Relatives. J.L. Molnar. Howard University College of Medicine.
Neurobiology
387. DEVELOPMENTAL BIOLOGY AWARD HYBRID
385. NEUROBIOLOGY AWARD HYBRID Hybrid Symposium Tue. 8:30 am—McCormick Place Convention Center, W175AB
C.J. Herrick Award Lecture in Neuroanatomy featuring 2017 Young Investigator Award Recipient, Florian Merkle. 8:30 385.1 The Impact of Neuroanatomy on My Career: From Adult Neurogenesis to in Vitro Disease Modelling. F. Merkle. University of Cambridge, United Kingdom. 9:00 385.2 Histopathological Changes in the Colon Accompany Dysmotility Following Experimental Spinal Cord Injury. A.R. White, T.K. Cooper, G.M. Holmes. Penn State University College of Medicine. 9:15 385.3 Promising effects of laser therapy and the natural latex protein on sciatic nerve crushed: Ultrastructural, sensory and functional study. F.J. Dias, A.B. Simões, E.d. Carmo, D.P. Cury, S.Y. Almeida, P.E. Dias, V.S. Fazan. University of Sao Paulo—Ribeirao Preto Medical School, Brazil, Universidad de La Frontera, Chile, Institute of Biomedical Sciences—Universidade de São Paulo, Brazil and School of Pharmaceutical Sciences of Ribeirão Preto—University of Sao Paulo, Brazil. 9:30 Therapeutic Effects of Long-Term Systemic Adipose-Derived Stem Cell Conditioned Medium in a Mouse Model of Amyotrophic Lateral Sclerosis. C.L. Walker, F.M. Kennedy, C.M. Fry, A.K. Iyer, Y. Du, K. March, K.J. Jones. Indiana University School of Medicine and Roudebush VA Medical Center. (744.9) 9:45 385.4 Quantification of Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, After Nociceptive Stimulation During the Neonatal Period. A.B. Simoes, G.R. Silva, E. Carmo, C. Giorgetto, V.S. Fazan. School of Medicine of Ribeirao Preto, Brazil.
386. ANATOMY IN THE 21ST CENTURY: ANATOMICAL NETWORKS AND SYSTEMS BIOLOGY Symposium Tue. 8:30 am—McCormick Place Convention Center, W175C Chaired: R. Diogo
Hybrid Symposium Tue. 8:30 am—McCormick Place Convention Center, W176AB Chaired: M. Jenkins Developmental Biology/Morphology H.W. Mossman Award Lecture in Developmental Biology featuring 2017 Young Investigator Award Recipient, Maria Barna 8:30 387.1 Specialized Ribosomes: A New Frontier in Gene Regulation, Organismal Biology, and Evolution. M. Barna. Stanford University. 9:00 387.2 A New Role of Ronin (Thap11) in the Neural Crest and Craniofacial Development in the Mouse. A. Achilleos, X. Tong, R.A. Poché. Baylor College of Medicine. 9:15 387.3 QTL Analysis of a Trade-Off in Bone Length Within the Mouse Zygomatic Arch. C.J. Percival, R. Green, D.M. Gatti, D. Pomp, C.C. Roseman, R. Marcucio, B. Hallgrímsson. University of Calgary, Canada, The Jackson Laboratory, University of North Carolina Medical School, University of Illinois and UCSF School of Medicine. 9:30 387.4 Females Are Not Proportionally Smaller Males: Relationships Between Radius Anthropometrics. M.L. Thom, J.M. Reeves, E. Lalone, K. Willmore, T.A. Burkhart. Schulich School of Medicine and Dentistry, Canada, Western University, Canada and Lawson Health Research Institute, Canada. 9:45 387.5 Inhibiting IGF1 Activity in the Proximal Tibial Growth Plate Attenuates the Bone-Lengthening Effects of Temperature in Hindlimbs of Growing Mice. H.L. Racine, C.A. Meadows, G. Ion, M.A. Serrat. Marshall University Joan C. Edwards School of Medicine.
388. PRECEDING PROFESSIONAL PROGRAMS: SUCCESSFUL ANATOMY EDUCATION IN THE UNDERGRADUATE CLASSROOM Symposium
Evolution/Anthropology
Tue. 8:30 am—McCormick Place Convention Center, W178A
Developmental Biology/Morphology
Chaired: D.C. Bentley
This session was funded and programmed in part by the AAA Innovations Program 8:30 386.1 Evo-Devo, Epigenetics, Niche Construction and the Extended Evolutionary Synthesis: Crucial Implications for Anatomical and Medical Sciences in the 21st Century. R. Diogo. Howard University.
Education 8:30 388.1 Movement Guided Learning as an Efficacious, Effective, and Evidence-Based Teaching Strategy Within the Undergraduate Anatomy Classroom. D.C. Bentley. Toronto Rehabilitation Institute, Canada.
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ANATOMY TUESDAY 9:00 388.2 Transforming a Large Anatomy Class Into a Student Centered Learning Experience. L. Mackenzie, A. Michels, L. Anstey. Queen’s University, Canada and Western University, Canada. 9:30 388.3 Strategies to Help Students Tackle Complicated Anatomical Terminology. J. Carnegie. University of Ottawa, Canada. 10:30 389.1 Prolonged Sensory Loss Results in Altered Cortico-Cortical Connectivity Patterns. P. Voss. McGill University, Canada. 11:00 389.2 An Anatomical Basis for Cortical Crossmodal Plasticity. M. Meredith, S.G. Lomber. Virginia Commonwealth University and University of Western Ontario, Canada. 11:30 389.3 Expansion of the Functional Border of the Audiovisual Cortex Following Partial Hearing Loss in Adulthood. B. Allman. University of Western Ontario, Canada.
390. CELL BIOLOGY AWARD HYBRID Hybrid Symposium Tue. 10:30 am—McCormick Place Convention Center, W175C Chaired: K. Kramer Cell Biology R.R. Bensley Award Lecture in Cell Biology featuring 2017 Young Investigator Award Recipient, Gloria Brar 10:30 390.1 Unraveling Gene Regulatory Mechanisms in Meiotic Differentiation. G. Brar, Z. Cheng, K. Van Dalfsen, A. Eisenberg, I. Hollerer. University of California-Berkeley. 11:00 390.2 Hepatic Lipolysis by β-Adrenergic Stimulation Is Inhibited by Ethanol Exposure. M. Schott, K. Rasineni, S. Weller, R. Schulze, C. Casey, M. McNiven. Mayo Clinic and University of Nebraska Medical Center. 11:15 390.3 Enhancing Plasmin Activity Prevents DietInduced Skeletal Muscle Calcification Following Injury. S.N. Moore, G.D. Hawley, B.H. Gibson, J.G. Schoenecker. Vanderbilt University. 11:30 390.4 The Consumption of Plasminogen Following Severe Burn and Its Implications in Muscle Calcification. B. Gibson, S. Moore-Lotridge, N. Mignemi, G. Hawley, W. Oelsner, J. Schoenecker. Vanderbilt University, Vanderbilt University Medical Center and Medical University of South Carolina. 11:45 390.5 Constitutive Cardiomyocyte Proliferation in the Postnatal Leopard Gecko (Eublepharis macularius). K. Jacyniak, M.K. Vickaryous. University of Guelph, Canada.
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391. MORPHOLOGICAL SCIENCES AWARD HYBRID Hybrid Symposium Tue. 10:30 am—McCormick Place Convention Center, W176AB Chaired: C. Holliday Developmental Biology/Morphology Morphological Sciences Award Lecture featuring 2017 Young Investigator Award Recipient, Shigeki Watanabe 10:30 391.1 Ultrafast Recycling of Synaptic Vesicles. S. Watanabe. Johns Hopkins University. 11:00 391.2 Malaria Derived Extracellular Vesicles Influence Human Neutrophils Function. K.A. Babatunde, M. Walch, I. Fellay, S. Kharoubi-Hess, L. Filgueira, I. Ghiran, P.Y. Mantel. University of Fribourg, Switzerland and Beth Israel Deaconess Medical Center. 11:15 391.3 Fascin Regulates Nuclear Actin During Drosophila Oogenesis. D.N. Kelpsch, C.M. Groen, T.N. Fagan, S.N. Sudhir, T.L. Tootle. Univeristy of Iowa and Mayo Clinic. 11:30 391.4 Studying Interaction of the Immune and Vascular System Using Intravital Multiphoton Microscopy. B.H. Zinselmeyer, B.T. Saunders, L. Huang, D. Runci, J.W. Williams, G.J. Randolph. Washington University School of Medicine. 11:45 391.5 Dynamic, Patient-Specific Mitral Valve Replicas for Anatomically Accurate Surgical Modelling. O. Ginty, J. Moore, D. Bainbridge, M.W. Chu, T. Peters. Western University, Canada and Robarts Research Institute, Canada.
392. ANATOMY EDUCATION PLATFORM 2— PEDAGOGY IN ANATOMY EDUCATION Platform Tue. 10:30 am—McCormick Place Convention Center, W178A Chaired: K. Metzger Education 10:30 392.1 A 50 Year Review and Meta-Analysis of Anatomy Laboratory Pedagogies. A. Wilson, C. Miller, B. Klein, M. Taylor, M. Goodwin, E. Boyle, K. Brown, C. Hoppe, M. Lazarus. Rush University Medical Center, Indiana University School of Medicine, George Washington University and Monash University, Australia. 10:45 392.2 Efficacy of Undergraduate Medical Education in Anatomical Sciences for Surgical Residency Preparation. R. Klaus, L. Lee. University of Colorado Anschutz Medical Campus.
TUESDAY ANATOMY 11:00 392.3 Does Motivation or Learning-Strategies Develop in a Flipped-Classroom? L. Day. Northeastern University. 11:15 392.4 The Long-Term Effects of an Interprofessional Education Dissection Course on Healthcare Professional Students. E. Zheng, A. Palombella, J. Salfi, I. Bayer, B. Wainman. McMaster University, Canada and Brock University, Canada. 11:30 392.5 Formative Assessments in Anatomy: Promoting Self-Directed Learning with Self-Assessment. V. Lee, K. Higgins, B. Schneider. TTUHSC. 11:45 392.6 The Relationship Between Learning and Study Strategies Inventory (LASSI) and Performance on Anatomical Sciences in Medical Schools. M.K. Khalil, H. Hawkins, S.E. Williams. University of South Carolina School of Medicine Greenville.
393. FORM AND FUNCTION PLATFORM Platform Tue. 2:00 pm—McCormick Place Convention Center, W175AB Chaired: A. Morhardt Developmental Biology/Morphology 2:00 393.1 Analysis of the Primate “Squeeze-Back” Swallowing Mechanism Using X-Ray Reconstruction of Moving Morphology and Fluoromicrometry. C.P. Orsbon, N.J. Gidmark, C.F. Ross. University of Chicago and Knox College. 2:15 Fluorescent Labeling in the Leopard Gecko Resolves Tooth Initiation Patterns in Ovo and Suggests Origins of Post-Hatching Shedding Patterns. T.M. Grieco, K.S. Brink, J.M. Richman. University of British Columbia, Canada. (743.14) 2:30 393.2 Visualizing the Anatomy and Position of the Larynx in Balaenopterid Whales. C.M. Smith, C. Ying Tang, J. Ng, J.S. Reidenberg. Icahn School of Medicine at Mount Sinai. 2:45 393.3 Free-Body Analysis of the Masticatory Muscles in a Caviomorph Rodent, Cavia porcellus. R.E. Druzinsky, A. Ulm, C.J. Vinyard, J. Iriarte-Diaz. University of Illinois at Chicago, and NEOMED. 3:00 393.4 Embryogenesis of the Nasolacrimal Apparatus in the Laysan Albatross (Phoebastria immutabilis: Procellariiformes). S.J. Rehorek, J. Cioccio, W.J. Hillenius, T.D. Smith. Slippery Rock University and College of Charleston. 3:15 393.5 Sexual Dimorphism in Bones of the Thenar and Hypothenar Aspects of the Hand. A.A. Williams, B.A. Patel, M.W. Tocheri, C.M. Orr. University of Colorado Anschutz Medical Campus, Keck School of Medicine, University of Southern California, Lakehead University, Canada, National Museum of Natural History, Smithsonian Institution, University of Colorado School of Medicine, University of Colorado at Denver.
394. DEVELOPMENTAL AND CELL BIOLOGY PLATFORM SESSION Platform Tue. 2:00 pm—McCormick Place Convention Center, W175C Chaired: R. Marcuccio Cell Biology Developmental Biology/Morphology 2:00 394.1 Investigating the Roles of Fascin in Collective Cell Migration Using Drosophila Border Cell Migration. M. Lamb, T. Tootle. University of Iowa. 2:15 394.2 Changes in Oligodendroglial and Microglial Cell Populations in the Embryonic Rat Spinal Cord Following Maternal Immune Activation. K.W. McDermott, R.C. Anderson, T. Foley, J. Radford, S. O’Halloran, G.W. O’Keeffe. University of Limerick, Ireland and University College Cork, Ireland. 2:30 394.3 Orphan Nuclear Receptor, GCNF, Is Required for Early Neural Crest Cell Induction and Survival. W.A. Munoz, S. Bhatt, J. Crane-Dennis, A. Achilleos, D. Sakai, A. Cooney, P. Trainor. Stowers Institute for Medical Research, Missouri Southern State University, Baylor College of Medicine and Doshisha University, Japan. 2:45 394.4 FoxO6 Regulates Hippo Signaling to Control Face Morphology. H. Cao, Z. Sun, C. de Fontoura, N. Holton, F. Bidlack, J. Martin, L. Moreno-Uribe, B. Amendt. The University of Iowa, The Forsyth Institute and Baylor College of Medicine. 3:00 394.5 Modular 3D Dense Surface Analysis and GWAS Reveal Localized Genetic Effects on Human Facial Morphology Involving Multiple Novel Loci. S.M. Weinberg, M. Lee, E.J. Leslie, E. Orlova, J.C. Carlson, J. Roosenboom, B.C. Mattern, C.R. Liebowitz, J.D. White, A. Zaidi, D. Hernandez, T. Gonzalez, L.N. Pearson, D. Sero, J. Li, E. Feingold, M.L. Marazita, J.R. Shaffer, J. Wysocka, M.D. Shriver, P. Claes. University of Pittsburgh, Penn State University, Katholieke Universiteit Leuven, Belgium and Stanford University. 3:15 394.6 LHX2 Is a Necessary Intermediate in FGFInduced SHH Expression During Limb Development. B.A. Watson, C.U. Pira, K.C. Oberg. Loma Linda University.
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395. STEM CELLS PLATFORM SESSION Platform
Award Lecture
Tue. 2:00 pm—McCormick Place Convention Center, W176AB
Tue. 4:00 pm—McCormick Place Convention Center, W176AB
Chaired: M. Dunnwald
Cardiovascular Biology
Stem Cells/ Regeneration 2:00 395.1 Propagating the Ovarian Cancer Stem Cells by Reprogramming the Tumor Cells. Y. Chen, C. Lu, W. Cheng, H. Ho, H. Cheng. Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taiwan, Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taiwan, Department of Obstetrics and Gynecology, College of Medicine and the Hospital, College of Medicine and National Taiwan University, Taiwan. 2:15 395.2 Spinal Cord Regeneration in the Leopard Gecko: Activation and Heterogeniety of Ependymal Layer Cells. E.A. Gilbert, M.K. Vickaryous. University of Guelph, Canada. 2:30 Contribution of Macrophages to Myxomatous Valve Disease. A. Hulin, S. Potter, A. Kim, T. DeFalco, K. Yutzey. CCHMC. (586.12) 2:45 395.3 Deformation-Induced Ingression of Transitional Pleural Myofibroblasts During Compensatory Lung Growth. A. Ysasi, R. Bennett, C. Valenzuela, A. Servais, A. Kienzle, W. Wagner, M. Ackermann, A. Tsuda, S. Mentzer. Harvard Medical School/Brigham and Women’s Hospital, Johannes Gutenberg University, Germany and Harvard School of Public Health. 3:00 395.4 Sonic Hedgehog (Shh) in Parotid Saliva Is a Cell Signaling Moiety That Acts as Stem Cells in Taste Buds to Maintain Normal Taste Function. R.I. Henkin, M. Abdelmeguid. Center for Molecular Nutrition and Sensory Disorders. 3:15 395.5 SPARC and Hevin in Mustard-Induced Skin Wound Healing. Y. Chang, H. Chang, R. Hahn, K.K. Svobada, M.K. Gordon, D.R. Gerecke. Ernest Mario School of Pharmacy, Rutgers University, and Texas A&M University, Baylor College of Dentistry.
396. LINKED MODULES IN ANATOMICAL INFERENCE: NEW APPROACHES TO MORPHOLOGICAL INTEGRATION Symposium Tue. 2:00 pm—McCormick Place Convention Center, W178A Chaired: E.R. Middleton Vertebrate Paleontology Developmental Biology/Morphology 2:00 396.1 From the Top of Your Head: Phenotypic Integration in the Head and Neck. C.I. Villamil. New York University and New York Consortium in Evolutionary Primatology. 2:30 396.2 The Modular Nature of the Trunk Skeleton in Anthropoid Primates. E.R. Middleton. University of Missouri. 3:00 396.3 Integration and Coevolution of the Mammalian Skeleton in “Real Time”: The Case of the Longshanks Mouse. C. Rolian. University of Calgary, Canada.
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397. HENRY GRAY SCIENTIFIC AWARD SYMPOSIA
4:00 Introduction. 4:05 397.1 Henry Gray Scientific Achievement Award Lecture. H. Yost. University of Utah. 4:20 Q & A.
398. HENRY GRAY DISTINGUISHED EDUCATOR AWARD SYMPOSIA Award Lecture Tue. 4:30 pm—McCormick Place Convention Center, W176AB Education 4:30 Introduction. 4:35 398.1 Getting to the Heart of Anatomical Sciences Education. W. Pawlina. Mayo Clinic College of Medicine and Science and Mayo Clinic. 4:50 Q & A.
399. A. J. LADMAN EXEMPLARY SERVICE AWARD SYMPOSIA Award Lecture Tue. 5:00 pm—McCormick Place Convention Center, W176AB 5:00 Introduction. 5:05 399.1 The Path to Anatomy via Molecular Biology. M.K. Gordon. Ernest Mario School of Pharmacy, Rutgers University. 5:20 Q & A.
TUESDAY BIOCHEMISTRY
Biochemistry and Molecular Biology 400. AVANTI AWARD IN LIPIDS Award Lecture (Sponsored by: Avanti Polar Lipids, Inc.) Tue. 8:45 am—McCormick Place Convention Center, W183AB 8:45 Introduction. 8:50 400.1 Phosphoinositide Conversion in the Endolysosomal System. V. Haucke, K. Ketel, A. Wallroth, A.L. Marat, W. Lo, C. Schultz. Leibniz Institut für Molekulare Pharmakologie, Germany and EMBL, Germany.
401. RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE AWARD Award Lecture (Sponsored by: ASBMB Minority Affairs Committee) Tue. 9:15 am—McCormick Place Convention Center, W183AB 9:15 Introduction. 9:20 401.1 From Dividing Cells to Helping Students Overcome Socio-Economic Barriers. D.N. Robinson. Johns Hopkins School of Medicine.
402. ORGANELLE TRAFFICKING AND SIGNALING Symposium Tue. 10:00 am—McCormick Place Convention Center, W183C Chaired: G.K. Voeltz 10:00 402.1 Unraveling the Mechanism of ER-Associated Organelle Fission. G.K. Voeltz. University of Colorado Boulder. 10:30 402.2 Why Mammalian Cells Respire? N.S. Chandel. Northwestern University Feinberg School of Medicine. 11:00 402.3 Nuclear Envelope Rupture Is Induced by ActinBased Nucleus Confinement. M. Hetzer, E. Hatch. The Salk Institute for Biological Studies and Fred Hutchinson Cancer Research Center. 11:30 402.4 Dynamics of Autophagy and Mitophagy in Neurons. E.L. Holzbaur. Perelman School of Medicine and University of Pennsylvania.
403. BIOCHEMICAL BASIS OF CELLULAR PROCESSES Symposium Tue. 10:00 am—McCormick Place Convention Center, W184BC Chaired: X. Wang 10:00 403.1 Dynamic Regulation of DNA Methylation. B. Zhu. Institute of Biophyisics, Chinese Academy of Sciences, People’s Republic of China. 10:30 403.2 A Novel Enzymatic DNA Modification on Methylcytosine. G. Xu. Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, People’s Republic of China. 11:00 403.3 Pyroptosis in Anti-Bacteria Immunity: Sensing and Execution. F. Shao. National Institute of Biological Sciences, Beijing, People’s Republic of China. 11:30 403.4 Mitochondrial Pathway of Apoptosis. X. Wang. National Institute of Biological Sciences, Beijing, People’s Republic of China.
404. ANTIBIOTIC RESISTANCE Symposium Tue. 10:00 am—McCormick Place Convention Center, W185BC Chaired: K. Lewis 10:00 404.1 Networks of Exchanging Antibiotic Resistance Between Environmental, Commensal, and Pathogenic Microbes. G. Dantas. Washington University School of Medicine. 10:30 404.2 Remarkable Functional Convergence: Type I and II Toxin-Antitoxins Induce Multidrug Tolerance by (p) ppGpp-Dependent Mechanisms. K. Gerdes. University of Copenhagen, Denmark. 11:00 404.3 Systems Chemical Biology: A Novel Approach to Antibiotic Discovery. D.T. Hung. Harvard and MGH. 11:30 404.4 Modeling the Gut Microbiota with Mathematical Ecology. J. Xavier. Memorial Sloan Kettering Cancer Center.
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405. GLYCOBIOLOGY, GLYCAN RECEPTORS AND FUNCTIONAL GLYCOMICS Symposium Tue. 10:00 am—McCormick Place Convention Center, W186ABC Chaired: N.M. Dahms 10:00 405.1 Deciphering the ZIP Codes of a Cell. N.M. Dahms. Medical College of Wisconsin. 10:30 405.2 Glycan-Binding Proteins as Microbial Detectors. L.L. Kiessling. University of Wisconsin—Madison. 11:00 405.3 O-Glycan Recognition and Function in Mice and Humans. R.D. Cummings. Beth Israel Deaconess Medical Center and Harvard Medical School. 11:30 405.4 Antibody Glycosylation: An Emerging Biomarker of Disease Activity/Protection. G. Alter. Ragon Institute of MGH, MIT and Harvard.
406. METAL HOMEOSTASIS
Special Event Tue. 12:30 pm—McCormick Place Convention Center, Hall F Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • N. Chandel, Northwestern Univ. Feinberg Sch. of Med. • V. Haucke, Leibniz Institut für Molekulare Pharmakologie, Avanti Award in Lipids • M. Hetzer, Salk Inst. for Biological Studies • E. Holzbaur, Univ. of Pennsylvania Perelman Sch. of Med. • D. Robinson, Johns Hopkins Sch. of Med., Ruth Kirschstein Diversity in Science Award • F. Shao, National Inst. of Biological Sciences, Beijing
Symposium
• G. Voeltz, Univ. of Colorado, Boulder
Tue. 10:00 am—McCormick Place Convention Center, W187ABC
• B. Zhu, Inst of Biophysics, Chinese Academy of Science
Chaired: A.C. Rosenzweig 10:00 406.1 Bacterial Copper Acquisition. A.C. Rosenzweig, G.E. Kenney, L.M. Dassama, S.Y. Ro. Northwestern University. 10:00 406.2 Mechanisms of Zinc Metallostasis in Bacterial Pathogens. D. Giedroc, D.A. Capdevila, J.E. Martin, K.A. Edmonds, H. Wu. Indiana University. 10:00 406.3 Metals and Immunity. E.M. Nolan. Massachusetts Institute of Technology. 10:00 406.4 Regulation of Manganese Homeostasis and Detoxification by the Efflux Transporter SLC30A10. S. Mukhopadhyay. The University of Texas at Austin.
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407. ASBMB MEET THE SPEAKERS
408. NIH AND NSF FUNDING OPPORTUNITIES Workshop Tue. 12:30 pm—McCormick Place Convention Center, W185BC • The Antibacterial Research and Carb-X Initiative, T. Guina and A. Sheoran, NIAID. • Alzheimers Disease Research, A. Yang, NIA, NIH. • NSF Funding Opportunities, D. Rockcliffe, Chemistry of Life Processes, NSF.
TUESDAY BIOCHEMISTRY
409. ASBMB MEET THE SPEAKERS
3:30
Special Event Tue. 1:30 pm—McCormick Place Convention Center, Hall F Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • N. Dahms, Medical Col. of Wisconsin • G. Dantas, Washington Univ. Sch. Of Med. • K. Gerdes, Univ. of Copenhagen • D. Hung, Harvard Univ. and Mass General • S. Mukhopadhyay, UT, Austin
3:45
Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study. J.N. Hackman, W. Sangster, J.P. Hegarty, K.M. Schieffer, J.R. Wright, D.R. Toole, R. Drucker, D.B. Stewart Sr., R. Lamendella. Juniata College, The Pennsylvania State University, Wright Labs and LLC. (940.8) Probiotics Alter Avian Serum Profile to Stimulate Energy Consumption and Change of Gene Expression in Immune Cells. A. Ballou, R. Ali, M. Koci. NC State University. (940.11)
411. BEYOND THE CODE: CHEMISTRY OF NUCLEOTIDE AND AMINO ACID MODIFICATIONS Symposium
• E. Nolan, MIT
Tue. 2:30 pm—McCormick Place Convention Center, W184A
• A. Rosenzweig, Northwestern Univ.
Chaired: L. Saleh
410. MICROBIOMES AND THEIR EVOLUTION DURING INFECTION AND DISEASE Symposium Tue. 2:30 pm—McCormick Place Convention Center, W183C Chaired: R. Page 2:30
Chronic Diabetic Wounds: Longitudinal Profiling of the Evolving Microbiome and Metabolic Landscape in Diabetic Patients. M.B. Ammons, A.L. Fuchs, B.P. Tripet, V. Copie, A.J. Weaver, A. Braaksma, E. Johnson, C. Yeoman. Montana State University and Bozeman Deaconess Health Hospital. (944.9) 2:45 Probiotic Escherichia coli Nissle 1917 Uses Zinc Transporters and the Siderophore Yersiniabactin to Acquire Zinc in the Inflamed Gut and Outcompete Salmonella typhimurium. J. Behnsen, J. Liu, M. Valeri, E. Hoover, J. Tjokrosurjo, N.P. Montaldo, S. Treacy-Abarca, O. Garibay, B.A. Gilston, R.A. Edwards, W. Chazin, E.P. Skaar, M. Raffatellu. University of California, Irvine, University of Illinois at Chicago, College of Medicine and Vanderbilt University. (622.6) 3:00 Bladder and Vaginal Microbiomes Have a Corresponding Shift Following Estrogen Treatment in Post-Menopausal Women. K. Thomas-White, S. Taege, D. Johansen, E.E. Hilt, C. Brincat, E.R. Mueller, L. Brubaker, A.J. Wolfe. Loyola University Chicago. (940.4) 3:15 The Metatranscriptome of the Rhesus Macaque: Investigating Potential Causes of Idiopathic Chronic Diarrhea. S.T. Westreich, A. Ardeshir, M.E. Kable, I. Korf, D.G. Lemay. University of California, Davis and USDA ARS Western Human Nutrition Research Center. (940.7)
2:30 Novel Thymidine Hypermodifications in Viruses Encoding a 5-Hydroxymethyl-5′-Deoxyuridine DNA Kinase. P.R. Weigele, S. Müller, Y. Lee, S. Walsh, C. Guan, N. Dai, I. Correa. New England Biolabs. (606.6) 2:45 A Shared Structural Recognition Element in mRNA Substrates of the tRNA Modifying Enzyme Pseudouridine Synthase 1. T.M. Carlile, T.A. Bell, M.F. Rojas-Duran, B. Zinshteyn, H. Shin, C. Mason, W.V. Gilbert. MIT. (595.3) 3:00 In Vitro Development of Synthetic Chromatin Proteins That Function in Live Cells. K.A. Haynes, S. Tekel, D.A. Vargas. Arizona State University. (922.8) 3:15 Deciphering the Logic of Natural Product Biosynthesis. B. Li. University of North Carolina at Chapel Hill. (607.9) 3:30 New Roles for Dithiolopyrrolones in Disrupting Bacterial Metal Homeostasis and Inhibiting Metalloenzymes. A.N. Chan, A.L. Shiver, W.J. Wever, S.Z. Razvi, M.F. Traxler. University of North Carolina at Chapel Hill, University of California at San Francisco, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Duke University, University of California at Berkeley. (766.15) 3:45 YTHDC2 Regulates Spermatogenesis Through Promoting the Translation of N6-MethyladenosineModified RNA. P.J. Hsu, Y. Zhu, H. Ma, Y. Cui, X. Shi, G. Luo, Z. Lu, H. Shi, Q. Dai, M. Clark, B. Shen, C. He. The University of Chicago, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, People’s Republic of China. (595.10)
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412. MOLECULAR MECHANISMS OF REGULATION IN PROTEOLYSIS Symposium Tue. 2:30 pm—McCormick Place Convention Center, W184BC Chaired: E.S. Radisky 2:30 412.1 Substrate Conformational Dynamics in Proteolysis. E.S. Radisky. Mayo Clinic Cancer Ctr. 2:45 Phosphorylation Regulates Apoptotic Caspase Function Through Diverse Molecular Mechanisms. J.A. Hardy, B.P. Serrano, S.J. Eron. University of Massachusetts. (602.3) 3:00 Proteasome Activation via a Functional Switch of the Rpt6 C-Terminal Tail Following Chaperone-Dependent Assembly. S. Park, F. Li, V. Sokolova. University of Colorado Boulder. (917.4) 3:15 Structure of hRpn13 at the Proteasome. X. Lu, F. Liu, U. Nowicka, V. Sridharan, M. Dyba, S.G. Tarasov, K.J. Walters. Center for Cancer Research, National Cancer Institute. (603.5) 3:30 The Intrinsically Disordered Membrane Enzymes Selenoprotein S and Selenoprotein K. S. Rozovsky, J. Liu, Z. Zhang. University of Delaware. (773.1) 3:45 The Cellular Demand for Protein Synthesis Influences the Ribosome Maintenance Program in Vivo. J.C. Price. Brigham Young University. (759.4)
413. RNA: SYNTHESIS, REGULATION, AND PROCESSING Symposium
3:15 Activation of Transcription-Coupled 5′RNA Capping by TFIIH. M. Noe-Gonzalez, J. Conaway, R. Conaway. Stowers Institute and Kansas University Medical Center. (907.1) 3:30 The Role of the Essential Splicing Factor Prp2 in Ribosome Biogenesis. S. Edwards, A. Hossain, T. Johnson. University of California at Los Angeles. (596.13) 3:45 Nonstop Decay in C. elegans: Examination of a Possible Role for Small Noncoding RNAs. E.M. Youngman. Villanova University. (757.21)
414. THERAPEUTICS: TARGETS AND DESIGN Symposium Tue. 2:30 pm—McCormick Place Convention Center, W185BC Chaired: K. Dalby 2:30
2:45
3:00 3:15
Tue. 2:30 pm—McCormick Place Convention Center, W185A Chaired: C. Kaplan 2:30 413.1 Mechanism and Regulation of RNA Polymerase II. C.D. Kaplan. Texas A&M. 2:45 Inhibiting Pathways Involved in B-Cell Development Enhances Sensitivity of B-Cell Acute Lymphoblastic Leukemia to Glucocorticoids. M.A. Pufall, K. Kruth, M.A. Fang, D. Shelton, O. Abu-Halawa, S.K. Tasian, M. Kampmann. University of Iowa, Bio-Rad, Coe College, Children’s Hospital of Philadelphia, University of California San Francisco. (756.20) 3:00 Regulation of RNA Polymerase Translocation by the RNA and DNA Hybridization at the Upstream Edge of the Transcription Bubble. M. Kireeva, C. Trang, G. Matevosyan, L. Lubkowska, M. Kashlev. NCI. (597.3)
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3:30
3:45
Mechanism and in Vivo Activity of a Covalent Inhibitor of ERK Docking. K.N. Dalby, E.V. Anslyn, D. ZamoraOlivares, T. Kaoud. University of Texas at Austin. (608.13) Elucidation of the Cell Death Pathways Induced by Aqueous-Stable Titanium(IV) Compounds as Potential Anticancer Agents. Y. Delgado, A. Vázquez, M. Kowaleff, M. Saxena, Z. Torres, A. Tinoco. University of Puerto Rico Rio Piedras Campus and City University of New York. (609.12) In Vivo Drug Discovery for Progressive Supranuclear Palsy Using a Novel Zebrafish Model. E.A. Burton, Q. Bai. University of Pittsburgh. (609.13) Insight Into the Mechanism and Structural Basis for Autoinhibition of PTEN by Phosphorylation of Its C-Terminal Tail. D.R. Dempsey, Z. Chen, S. Thomas, D. Hayward, D. Bolduc, P. Cole. Johns Hopkins University. (771.1) Trehalose-6-Phosphate Phosphatase Structure and Inhibitor Design. C. Harvey, C. Liu, D. Globisch, K. Janda, D. Dunaway-Mariano, K. Allen. Boston University, University of New Mexico and The Scripps Research Institute. (923.5) Carbohydrate-Linked Cisplatin Analogue: Reactivity Studies with RNA and DNA. S.D. Thalalla Gamage, N. Muthunayake, A. Sonousi, D. Crich, C. Chow. Wayne State University. (608.8)
TUESDAY BIOCHEMISTRY
415. THE INTEGRATION OF METABOLISM AND EPIGENETICS
2:45
Symposium Tue. 2:30 pm—McCormick Place Convention Center, W186ABC
3:00
Chaired: M. Hirschey 2:30 415.1 Epigenetic Control of Gene Expression by Lipid Metabolism. M. Hirschey. Duke Univ. 2:45 Regulation of Histone Methylation via Methionine Metabolism. S.A. Haws, J.M. Denu. University of Wisconsin-Madison, Wisconsin Institute for Discovery and University of Wisconsin-Madison School of Medicine and Public Health. (755.9) 3:00 Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. D. Zhang, Z. Xie, D. Chung, Z. Tang, H. Huang, L. Dai, S. Qi, J. Li, G. Colak, Y. Chen, C. Peng, H. Ruan, D. Wang, L.M. Jensen, O. Kwon, S. Lee, S.D. Pletcher, M. Tan, D.B. Lombard, K.P. White, H. Zhao, J. Li, R.G. Roeder, X. Yang, Y. Zhao. Medical University of South Carolina, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China, University of Minnesota Twin Cities, Yale University School of Medicine, University of Michigan, Kyungpook National University, Republic of Korea, Yale University and Yale School of Medicine. (755.2) 3:15 Hepatic Fat Accumulation Regulates Carnitine Palmitoyltransferase 1 (Cpt1a) Expression Through Coordinated Epigenetic Mechanisms. L. Moody, P.M. Jung, A. Kriska, H. Chen, Y. Pan. University of Illinois Urbana Champaign. (625.1) 3:30 Obesity-Mediated Regulation of the Cardiac Acetylome. S.S. Romanick, A. Hostler, K. Schlauch, D. Quilici, Y. Feng, B. Ferguson. University of Nevada Reno. (602.14) 3:45 Effects of Acute Aerobic Exercise on Whole Genome Nucleosome Maps and Gene Expression in Skeletal Muscle of Lean vs Overweight/Obese Men. P.M. Devarshi, A.D. Jones, W.W. Campbell, E.M. Taylor, T.M. Henagan. Purdue University. (943.3)
416. INTRINSIC DISORDER AND RECOGNITION Symposium Tue. 2:30 pm—McCormick Place Convention Center, W187A
3:15
3:30
3:45
BECN Homologs and ATG14 Form a Metastable CoiledCoil to Mediate Autophagy. S. Sinha, M. Su, Y. Li, B. Levine, C. Colbert. North Dakota State University, Howard Hughes Medical Research Institute and University of Texas Southwestern Medical Center. (760.24) Fis1 Activity in Pre- and Post-Assembly of the Yeast Mitochondrial Fission Machinery. M.C. Harwig, R.B. Hill. Medical College of Wisconsin. (634.8) The Conformation of Apolipoprotein E4 on Discoidal and Spherical High Density Lipoproteins Using Chemical Crosslinking and Fluorescence Spectroscopy. N. Bala, K. Taiwo, V. Narayanaswami. California State University at Long Beach. (761.26) Insights Into HuR RRM1-2 Tandem Domains SelfAssociation and mRNA Recognition. A.S. Pinheiro, C. Lixa, K.A. Jendiroba, L.T. Lima, M.T. de Magalhães, F.C. Almeida. Federal University of Rio de Janeiro, Brazil and Federal University of Minas Gerais, Brazil. (598.5) Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Y. Lin. University of Texas Southwestern Medical Center. (760.4)
417. NUTRITION IMPACT ON BACTERIA AND HOST HEALTH: FROM BASIC SCIENCE TO GLOBAL VIEW Symposium (Guest Society: Society for Experimental Biology and Medicine) Tue. 3:00 pm—McCormick Place Convention Center, W184D Chaired: C. Allred 3:00 3:10
Chair’s Introduction. Microbial Tryptophan Metabolites and Gut Health. A. Jayaraman. Texas A&M University. 3:35 Host-Microbe Interactions in the Human Infant: Impact of Nutrition. S. Donovan. University of Illinois. 4:00 Legumes and gut health. M. Manary. Washington University. 4:25 Diet Drives Colon Cancer Risk by its Effect on the Microbiota. S. O’Keefe. University of Pittsburg Medical Center. 4:50 Discussion.
Chaired: B. Hill 2:30
Multidimensional Chemical Control of CRISPR-Cas9. C.L. Moore, B. Maji, A. Choudhary, M. Shoulders. MIT, Broad Institute and Harvard Medical School. (909.5)
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418. ADVANCES IN GLYCOBIOLOGY Symposium Tue. 4:15 pm—McCormick Place Convention Center, W183C Chaired: K. Ribbeck 4:15 418.1 Probing Microbial Interactions with the Mucus Barrier. K. Ribbeck. MIT. 4:30 Bifidobacterium dentium Regulates Intestinal Mucus Production and Glycosylation. M.A. Engevik, B.K. Luk, C. Visuthranukul, J. Versalovic. Baylor College of Medicine, Texas Children’s Hospital and King Chulalongkorn Memorial Hospital, Thailand. (954.5) 4:45 Microbiota-Sensing O-GlcNAc Signaling in Intestinal and Metabolic Homeostasis. H. Ruan, M. Zhao. University of Minnesota. (784.4) 5:00 Toward Facile Automated Glycan Synthesis: Current Progress and Remaining Challenges. N.L. Pohl. Indiana University. (784.10) 5:15 Glycolipid Storage and Phenotypes in a New Rat Model of Fabry Disease. J.J. Miller, K. Aoki, C.A. Murphy, C.L. Stucky, I.S. Kassem, M. Tiemeyer, N.M. Dahms. Medical College of Wisconsin and University of Georgia. (953.2) 5:30 Imaging Specific Glycan Epitopes on Cells Using Glycosyltransferases via Click Chemistry. Z.L. Wu, A. Person, M. Anderson, B. Burroughs, R. Sackstein, T. Geders. Bio-techne, Brigham & Women’s Hospital and Harvard Medical School. (784.7)
419. CHEMICAL PROBES AND METABOLITE BIOSENSORS Symposium Tue. 4:15 pm—McCormick Place Convention Center, W184A Chaired: M. Hirschey 4:15 4:30
4:45
130
Designing Highly Specific Protein-Based Small Molecule Biosensors. S. Raman. University of WisconsinMadison. (765.3) Development of Algorithmic Techniques for Designing Electrochemical DNA Biosensors. A.J. Bonham, A.J. Bulow. Metropolitan State University of Denver. (767.2) Development of Red Fluorescent Protein pH Sensors. M. Rajendran, E. Haynes, B. Claywell, U. Scales, C. Henning, M. Tantama. Purdue University. (767.3)
5:00
Sensitive and Specific Detection of Ligands Using Engineered Riboswitches. J.P. Laney, D.P. Morse. United States Naval Academy. (907.4) 5:15 Bead-Based Enzymatic Assay On-A-Chip. S.J. Karnik, S. Cahoon, A. Bhushan. Illinois Institute of Technology. (924.5) 5:30 Lanthanide-Based FRET Biosensors for Time-Gated Imaging and Detection of Protein-Protein Interactions in Live Mammalian Cells. T. Chen, H. Pham, L. Miller. UIC. (767.6)
420. CANCER SIGNALING AND THERAPEUTICS Symposium Tue. 4:15 pm—McCormick Place Convention Center, W184BC Chaired: K. Wood 4:15
Leveraging Synthetic Lethality to Target Convergent Therapeutic Resistance. K.C. Wood. Duke University. (775.4) 4:30 CEBPD Is an Early Endoplasmic Reticulum Stress Response Gene Implicated in Breast Cancer Cell Survival. N. Sheshadri, S. Sharan, E. Sterneck. National Cancer Institute. (758.2) 4:45 Manipulating the Bone Marrow Microenvironment to Prevent Survival of AML Cells. R.M. Sterner, K.N. Kremer, A. Dudakovic, J.J. Westendorf, A.J. van Wijnen, K.E. Hedin. Mayo Clinic. (775.3) 5:00 Deconstructing the Peptide Specificity of TCR Recognition. T.P. Riley, J. Mendoza, L. Hellman, K. Garcia, B. Baker. University of Notre Dame and Stanford School of Medicine. (760.1) 5:15 Mortalin Modulates MEK/ERK Activity by Regulating the Physical Interaction Between MEK1/2 and Protein Phosphatase 1 Alpha. P. Wu. Medical College of Wisconsin. (775.1) 5:30 At the Crossroads Between TYR and SER/THR Signaling: A New Paradigm in the Regulation of PP2A by SRC Kinase. E. Sontag, J. Sontag, R.J. Gomez, A. Hoffman, G. Taleski, M.D. Mazalouskas, S.K. Hanks, I. Frohner, E. Ogris, B.E. Wadzinski. University of Newcastle, Australia, Vanderbilt University School of Medicine and Medical University of Vienna, Austria. (771.2)
TUESDAY BIOCHEMISTRY
421. CHROMATIN STRUCTURE AND EPIGENETIC REGULATION Symposium Tue. 4:15 pm—McCormick Place Convention Center, W185A Chaired: P. Grant 4:15 421.1 The Replication Kinase Cdc7 Marks Histones to Regulate Biosynthesis Genes. P. Grant. University of Virginia School of Medicine. 4:30 Chromatin Accessibility of the Dosage Compensated Drosophila Male X-Chromosome Is Established by a Context-Specific Role for the CLAMP Zinc Finger Protein. E. Larschan, J. Urban, G. Kuzu. Brown University. (593.10) 4:45 Epigenetic Manipulation of Inactive X Chromosome for Rett Syndrome Therapeutics. S. Bhatnagar. University of Virginia School of Medicine. (593.4) 5:00 Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J.K. Low, A.P. Silva, M. Sharifitabar, M. Torrado, J. Schmidberger, S.R. Webb, H. Saathoff, B.L. Parker, B. Paudel, A. van Oijen, M.J. Landsberg, N.E. Shepherd, J.P. Mackay. The University of Sydney, Australia, The University of Wollongong, Australia and The University of Queensland, Australia. (594.3) 5:15 Role of Chromatin Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination Mediated Gene Silencing. H. Wang, Z. Zhang, A.E. Jones, M.B. Renfrow, C. Liu, W. An, J. Luo, W. Wu, Y. Kang, Y. Tong. University of Alabama at Birmingham, Nanyang Technological University, Singapore, University of Southern California, Chinese Academy of Sciences, People’s Republic of China, and University of Toronto, Canada. (593.6) 5:30 Epigenetic Regulation Through UHRF Proteins. S.B. Rothbart, R.M. Vaughan, E.M. Cornett, B.M. Dickson. Van Andel Research Institute. (595.4)
422. LIPID TRANSPORT AND PROCESSING Symposium Tue. 4:15 pm—McCormick Place Convention Center, W186ABC Chaired: A. Radhakrishnan 4:15
4:30
Probing the Lipid Composition at the Site of Influenza Virus Assembly and Budding with HighResolution SIMS. M.L. Kraft, A.N. Yeager, P.K. Weber, J. Zimmerberg. University of Illinois at Urbana-Champaign, Lawrence Livermore National Laboratory, National Institute of Child Health and Human Development, National Institutes of Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development. (629.20) Macrophage Catabolism of Aggregated Lipoproteins Using a Novel Extracellular Compartment Regulates Lipid Accumulation During Atherosclerosis. R.K. Singh, A.S. Haka, V.C. Barbosa-Lorenzi, A. Asmal, F. Lund, Y. Xiong, H.F. Chin, I. Grosheva, T. Hla, F.R. Maxfield. Weill Cornell Medical College. (782.17)
4:45
5:00
5:15
5:30
Macrophage Cholesterol Efflux and Atherosclerosis in Psoriasis: A Role for microRNA-33. D. Karunakaran, G. Dwevidi, K. Rayner. University of Ottawa Heart Institute, Canada. (947.7) Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection. F. Lu, M. Brown, J. Goldstein. University of Texas Southwestern Medical Center. (630.17) Ceramide-1-Phosphate: Characterizing a Fluorescent Lipid and Discovering New Binding Proteins. C.M. Shirey, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend. (629.24) A Novel Hemolysin with Anti-Cancer and Anti-Fungal Properties Binds to Serum Glycoproteins and Cholesterol. C. Welch, N. Fan, R. Brown, M. Talaga, A. Fueri, K. Driscoll, K. Lawry, A. Vizurraga, R. Rekhi, P. Bandyopadhyay, T. Dam. Michigan Technological University. (953.4)
423. MOLECULAR MACHINES OF PROTEIN SYNTHESIS AND DEGRADATION
T U E
Symposium Tue. 4:15 pm—McCormick Place Convention Center, W187A Chaired: K. Walters 4:15
ALS and Ubiquilin-2: Effects of ALS Mutations on Ubiquilin-2 Structure and Function. C. Castaneda, T. Dao. Syracuse University. (914.11) 4:30 Repeat Expanded Ataxin-1 mRNA and Protein Is CoRegulated at PML Bodies. D. Fanslow, A. Cogswell, C. Strojny, A. Garza-Gongora, E. Smith, S. Kosak. Northwestern University. (915.7) 4:45 Inter-Domain Interactions in Nascent Polypeptides Interfere with Productive Protein Folding. K. Liu, K. Maciuba, C. Kaiser. Johns Hopkins University. (604.10) 5:00 A Neuronal-Specific Surface-Exposed Membrane Proteasome Complex Modulates Neuronal Signaling Through Extracellular Signaling Peptides. K.V. Ramachandran, S.S. Margolis. Johns Hopkins School of Medicine. (915.4) 5:15 Nitrogen Starvation and Rapamycin Both Induce Autophagic Degradation of Proteasome Complexes. J. Roelofs, K.A. Waite, G. Vontz, A. De La MotaPeynado. Kansas State University. (917.6) 5:30 Multivalent Interactions Between a Ubiquitin Ligase and Its Substrates Mediate Their Recruitment to Liquid Membrane-Less Organelles. T. Mittag, J. Bouchard, E. Martin, J. Otero, S. Marada, S. Ogden. St. Jude Children’s Research Hospital. (916.3)
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424. PROTEIN AND ENZYME ALLOSTERY Symposium
426. PUBLISHING IN THE JBC 101: ADVICE FROM THE EXPERTS
Tue. 4:15 pm—McCormick Place Convention Center, W187B
Workshop
Chaired: W. Peti
Tue. 6:15 pm—McCormick Place Convention Center, W185BC
4:15
Using Dynamics and Structure to Understand Allostery in Signaling Enzymes. W. Peti. University of Arizona. (607.2) 4:30 Allosteric Landscape of a Stress-Inducible Human Hsp70 Molecular Chaperone. W. Meng, E.M. Clerico, N. McArthur, L.M. Gierasch. University of Massachusetts and Amherst. (604.14) 4:45 A Common Mechanism of Proteasome Impairment by Neurodegenerative Disease-Associated Oligomers. T.A. Thibaudeau, R. Anderson, D.M. Smith. West Virginia University and School of Medicine. (763.8) 5:00 Phospholipase A2: A Unique Paradigm of Allosteric Regulation by Membranes. V. Mouchlis, J. McCammon, E. Dennis. UC San Diego. (765.9) 5:15 Correlation of Fitness Landscapes from Three Orthologous TIM Barrels Originates from Sequence and Structure Constraints. Y.H. Chan, S.V. Venev, K.B. Zeldovich, C.R. Matthews. UMass Medical School. (761.27) 5:30 Allosteric Regulation and Enzymatic Mechanism of YopJ Family of Bacterial Effectors. J. Song, Z. Zhang, K. Ma, L. Gao, W. Ma. University of California at Riverside. (765.4)
425. LIPIDIC CUBIC PHASE CRYSTALLOGRAPHY Workshop (Sponsored by: JBC and LI-COR) Tue. 6:15 pm—McCormick Place Convention Center, W184BC Chaired: A. Kruse and A. Manjlik Lipidic cubic phase crystallography and related methods have transformed membrane-protein structural biology. They have led us to most of the known structures of G-protein-coupled receptors, as well as structures of many other membrane proteins, enzymes and transporters. This workshop will focus on how to crystallize membrane proteins by the lipidic cubic phase method and will include a live hands-on demonstration of the technique.
(Sponsored by: JBC and LI-COR)
Chaired: F.P. Guengerich and K. Sakabe Interested in publishing your research in the Journal of Biological Chemistry? Make sure you are presenting your research rigorously, clearly and compellingly! The JBC editors discuss important aspects authors need to consider when preparing their manuscripts for submission. Topics to be discussed include clarity of the text, including title and abstract, data presentation, database compliance, and transparency.
427. PRINCIPLES AND APPLICATIONS OF MODERN KINETIC AND EQUILIBRIUM ANALYSIS Workshop (Sponsored by: JBC and LI-COR) Tue. 6:15 pm—McCormick Place Convention Center, W186ABC Chaired: K. Johnson This workshop will teach attendees how to answer important questions about enzyme mechanisms by designing the right experiments and interpreting them quantitatively. It will present basic foundations and applications of kinetic analysis, then cover topics ranging from chemical kinetics and enzymology to pharmacokinetics and cell biology. It will demonstrate the use of KinTek computer simulation software to fit multiple data sets simultaneously, including kinetic and equilibrium measurements. Attendees will learn how to perform a wide range of experiments and interpret them rigorously, without simplifying approximations and errors inherent in fitting data using equations. The workshop will be taught by Kenneth Johnson at The University of Texas and founder of KinTek Corporation, a leader in precision stepped-flow and quench-flow instruments for rapid transient reaction kinetics.
428. ASBMB WOMEN SCIENTISTS MENTORING AND NETWORKING EVENT Special Event Tue. 7:30 pm—Hyatt Regency McCormick Place, Grant Park B Join us for lively conversation focusing on the importance of mentors and sponsors at the various stages of career development and factors that affect the success of mentoring relationships. ASBMB members and biochemistry attendees welcome.
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Nutrition 25. NUTRITIONAL SCIENCES COUNCIL BUSINESS MEETING AND BREAKFAST Forum (Sponsored by: Nutritional Sciences Council) Tues. 7:00 am—McCormick Place Convention Center, S105BCD Chaired: S. Adams
429. EXPLORING MEASUREMENT ERROR AND ITS IMPLICATIONS FOR DIET AND PHYSICAL ACTIVITY DATA Symposium Tue. 8:00 am—McCormick Place Convention Center, S100BC Chaired: A.F. Subar 8:00
8:25 8:50 9:15
9:40
A Comparison of Web-based Self-reported 24-hr Recalls, Food Frequency Questionnaires, and Food Records to Recovery Biomarkers. Yikyung Park. Washington Univ. in St. Louis, Sch. of Med. Measurement Error Structure of Dietary Self-reports in IDATA: Recalls, Records, and Questionnaires. Kevin Dodd. National Cancer Inst. Physical Activity Assessment: Working with What is Available and Anticipating the Future. Heather Bowles. National Cancer Inst. The Measurement Error Properties of Physical Activity Data Collection Instruments: Physical Activity Questionnaire, ACT24, Activity Monitors. Victor Kipnis. National Cancer Inst. Expanding the Study of Measurement Error in Diet and Physical Activity Measurement Instruments: The Multi-cohort Eating and Activity Study for the Understanding of Reporting Error (MEASURE). Amy Subar. National Cancer Inst.
430. IMPLEMENTATION RESEARCH IN NUTRITION: PURPOSES, METHODS AND APPLICATIONS Symposium Tue. 8:00 am—McCormick Place Convention Center, S100A Chaired: D. Pelletier and M. Arabi 8:00 8:20
Implementation Science: Frameworks, Applications and Critical Contributions to Advancing Global Public Health Nutrition. David Pelletier. Cornell Univ. Application of Implementation Science Framework and Embedded Implementation Research Within One Intervention Area: The Case of Infant and Young Child Nutrition (IYCN) Program. Lynnette Neufeld. Global Alliance for Improved Nutrition.
8:40 Advancing Implementation Science in Nutrition: Experiences from the NIH-PEPFAR PMTCT Implementation Science Alliance. Rachel Sturke. NIH Fogarty International Center.
431. CARDIOVASCULAR EFFECTS OF DIETARY BIOACTIVE COMPONENTS Oral Tue. 8:00 am—McCormick Place Convention Center, S102BC 8:00 431.1 The Impact of Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: An Acute Dose Response Study. E. Park, Y. Huang, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Illinois Institute of Technology, University of California at Davis. 8:15 431.2 Watermelon and L-Arginine Consumption Regulate Gene Expression Related to Serum Lipid Profile, Inflammation, and Oxidative Stress in Rats Fed an Atherogenic Diet. J. Beidler, S. Hooshmand, M. Kern, A. Figueroa, M. Hong. San Diego State University and Florida State University. 8:30 431.3 Daily Mango (Mangifera indica L.) Consumption for 42 Days Differentially Modulates Metabolism and Inflammation in Lean and Obese Individuals. C. Fang, H. Kim, R. Barnes, S.T. Talcott, S.U. Mertens-Talcott. Texas A&M University. 8:45 431.4 Raspberries Modulate Postprandial Glycemia and Markers of Lipid Oxidation and Inflammation in Type 2 Diabetes. J. Schell, N. Betts, A. Basu. Oklahoma State University. 9:00 431.5 Strawberry Supplementation Lessens Vascular Inflammation and Dysfunction Displayed by Diabetic db/db Mice. C. Petersen, D. Bharat, B. Cutler, S. Gholami, C. Denetso, J. Mueller, J. Cho, J. Kim, J. Symons, A. Pon Velayutham. University of Utah. 9:15 431.6 Mechanism of Neuroprotectin D1 Action After Hypoxic-Ischemic Injury in Neonatal Mice. H. Zirpoli, S. Sosunov, Z. Niatsetskaya, K. Mayurasakorn, D. Kollareth Manual, P. Norris, I. Reilly, Serhan, V. Ten, R. Deckelbaum. Columbia University Medical Center and Brigham and Women’s Hospital and Harvard Medical School. 9:30 431.7 Consumption of 2 Eggs Per Day as Compared to an Oatmeal Breakfast Increases Plasma Carotenoids and Markers Associated with Reverse Cholesterol Transport in Young, Healthy Individuals. A.C. Missimer, D.M. DiMarco, A. Murillo, C.L. Millar, C.N. Blesso, M. Fernandez. University of Connecticut. 9:45 431.8 Effect of Tocotrienol and Statin on Glucose Homeostasis in High-Fat-Diet-Induced Obese Mice. K. Wright, G. Kaur, M.D. Tomison, G. Ogunmokun, A. Rodriguez, J. Dufour, R. Quintana, C. Shen. Texas Tech University Health Sciences Center.
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432. NUTRITION EDUCATION AND BEHAVIOR IN SCHOOL-AGED CHILDREN Oral Tue. 8:00 am—McCormick Place Convention Center, S102D Chaired: R. Scherr and H. Muzaffar 8:00 432.1 Comparison of Common Threads Cooking and Nutrition Education Program in Elementary and Middle School Students. N.K. Edens, S. Folkens, S. Sharma, A. Wojtowicz. Common Threads. 8:15 432.2 Sustained Effects of an Intervention to Improve Willingness to Try New Foods on Preschoolers’ Liking Ratings of a Target Vegetable. K.J. Moding, L.L. Bellows, C. Palmer, S.L. Johnson. University of Colorado Anschutz Medical Campus and Colorado State University. 8:30 432.3 Providers’ Perceptions of Child Feeding and Activity Recommendations Related to Early Childhood Obesity Prevention. R. Heller, J. Chiero, N. Trout, A.R. Mobley. University of Connecticut and Connecticut Children’s Medical Center. 8:45 432.4 Agent-Based Modeling of Social Norm Impacts on Obesity and Eating Behaviors Among School Children in China and the United States. H. Xue, J. Zhang, F. Xu, Y. Wang. Ball State University, Gannon University, Nanjing Municipal Center for Disease Control and Prevention, People’s Republic of China. 9:00 432.5 Using Theory to Develop an Experiential Physical Activity Curriculum. D.S. Fetter, R.E. Scherr, J.D. Linnell, J.J. Bergman, M. Byrnes, M. Gerdes, L.D. Ruiz, S. Zidenberg-Cherr. University of California, Davis, Oregon State University Extension Service, Tillamook and Lincoln Counties, University of California CalFresh Nutrition Education Program and University of California Agriculture and Natural Resources. 9:15 432.6 The Association Between Socio-Demographic and Anthropometric Variables and Food Literacy Scores in Elementary School Children. S. Skeaff, L. Ware, N. Davis, D. Power, K. Russell, C. Cameron, M. Skeaff. University of Otago, New Zealand. 9:30 432.7 Do Child Eating Behaviors Moderate Relationships Between Food Parenting Practices and Child Food Preferences? R.L. Vollmer, J. Baietto. Bradley University and Illinois State University. 9:45 432.8 Evaluation of High School Students’ Intrinsic Motivation and Perceived Competence to Cook Using the Adolescent Motivation to Cook Questionnaire. D. Miketinas, M. Cater, A. Bailey, K. Rhea, G. Tuuri. Louisiana State University and Louisiana State University Agricultural Center.
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433. OBESITY DIAGNOSIS AND TREATMENT Oral Tue. 8:00 am—McCormick Place Convention Center, S103A Chaired: K. Balantekin and H. Nicastro 8:00 433.1 3D Imaging Technology for Human Body Size and Shape Analysis: Comparison of Three Different Acquisition Technologies. B. Bourgeois, D. Latimer, C.R. Stannard, L. Romeo, X. Li, J. Shepherd, B.K. Ng, S.B. Heymsfield. Pennington Biomedical Research Center, Louisiana State University, Louisiana State University, University of California at San Francisco. 8:15 433.2 Validity of Weight Screening Approaches to Proximate Body Composition in Service Members with Lower Limb Amputation. B. George, K. Lee, W. Song, A.L. Pruziner, A.A. Andrews. Michigan State University, Walter Reed National Military Medical Center and National Institute of Standards and Technology. 8:30 433.3 Determining the Accuracy and Reliability of Indirect Calorimeters Utilizing the Methanol Combustion Technique. S. Kaviani, D.A. Schoeller, E. Ravussin, E. Melanson, S.T. Henes, L.R. Dugas, R.E. Dechert, G.E. Mitri, P.F. Schoffelen, P. Gubbels, A. Tornberg, S. Fritzdorf, M. Akkermans, J.A. Cooper. University of Georgia, University of Wisconsin-Madison, Pennington Biomedical Research Center, University of Colorado Anschutz Medical Campus, Georgia State University, Loyola University Chicago, University of Michigan Health System, Maastricht Univeristy Medical Centre, Netherlands, Topsport Expertise & Innovation Centre, Netherlands, Lund Univerisity, Sweden and Center of Expertise for Chronic Organ Failure, Netherlands. 8:45 433.4 Food Addiction and Dietary Intake in Morbidly Obese Females Before and After Vertical Sleeve Gastrectomy. A. Kim, C. Moore, V. Sherman, N. Tariq, M. Maziarz. Texas Woman’s University and Houston Methodist Hospital. 9:00 433.5 Dietary Fiber Supplementation Normalizes Serum Metabolites of Adults with Overweight/obesity in a 12Week Randomized Control Trial. S. Mayengbam, J.E. Lambert, J.A. Parnell, J.M. Tunnicliffe, J. Han, T. Sturzenegger, H.J. Vogel, J. Shearer, R.A. Reimer. University of Calgary, Canada, Mount Royal University, Canada, Alberta Agriculture and Rural Development, Canada, Cumming School of Medicine and University of Calgary, Canada. 9:15 433.6 The Impact of Avocado Fruit on Postprandial Satiety: An Acute Dose Response Study. Y. Huang, E. Park, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Institute for Food Safety and Health, Illinois Institute of Technology, University of California at Davis. 9:30 433.7 High Vitamin D Intake Improves Bone Health in Obesity. I.N. Sergeev. South Dakota State University. 9:45 433.8 What Monitoring Strategies Are Most Successful for Promoting Weight Loss? M.R. Jospe, M. Roy, R.C. Brown, S.M. Williams, H.R. Osborne, K.A. MeredithJones, J.R. McArthur, E.E. Fleming, R.W. Taylor. University of Otago, New Zealand.
TUESDAY NUTRITION
434. NUTRITIONAL IMMUNOLOGY AND INFLAMMATION Oral Tue. 8:00 am—McCormick Place Convention Center, S103BC Chaired: S.S. Comstock and E. Ananieva 8:00 434.1 Obesity Resets the Metabolic Profile of T Cells, Resulting in Reduced Memory T Cell Responses to Influenza Infection. J. Rebeles. UNC Chapel Hill. 8:15 434.2 Soluble Dietary Fiber in Obesity-Associated Inflammation and Oxidative Stress in African American Women. S.A. Nance, A.V. Duncan, T.M. Gwathmey, K.G. Hairston. Wake Forest University School of Medicine. 8:30 434.3 Altered Metabolism and Function of T Cells Isolated from Influenza Vaccinated Obese Adults. W.D. Green, J. Rebeles, T.J. Noah, M.G. Hudgens, S.S. Weir, N.J. MacIver, M.A. Beck. University of North Carolina at Chapel Hill and Duke University. 8:45 434.4 Impact of Maternal Obesity and High Fat Diet During Pregnancy and Lactation on Offspring Body Weight, Immune Function, and Resistance to Influenza Infection. W. Guo, D. Wu, L. Li, D.E. Smith, S.N. Meydani. JM USDA Human Nutrition Research Center on Aging at Tufts University. 9:00 434.5 Transcriptome Analysis Reveals Persistent Effects of Neonatal Diet on Small Intestine Gene Expression Profile in a Porcine Model. M.K. Saraf, A.K. Bowlin, C. Chen, H. Dawson, T.M. Badger, V. Yeruva. Arkansas Children’s Nutrition Center, UAMS, USDA-ARS Human Nutrition Research Center and ACRI. 9:15 434.6 Human Breast Milk Feeding Induces Stronger Humoral Immune Response Than Formula Feeding in Neonatal Porcine Model. V. Yeruva, M.K. Saraf, A.K. Bowlin, T.M. Badger. Arkansas Children’s Nutrition Center. 9:30 434.7 Supplemental Protein and Multi-Nutrient Beverage Improve Immune Response at Experimental Wound Site During 72-h Sleep Restriction. T.J. Smith, M.A. Wilson, A.J. Young, S.J. Montain. U.S. Army Research Institute of Environmental Medicine. 9:45 434.8 Myeloid Derived Suppressor Cells (MDSC) Are Vitamin D Targets and 1α, 25 Dihydroxyvitamin D (1,25(OH)2d) Inhibits Their Ability to Suppress T Cell Function. R.D. Calvert, G.N. Burcham, T.L. Ratliff, J.C. Fleet. Purdue University and Southern Indiana Purdue Agricultural Center.
435. DIET AND CANCER: ANIMAL STUDIES AND BIOMARKERS Oral Tue. 8:00 am—McCormick Place Convention Center, S103D Chaired: L. Yan and Z. Liu 8:00 435.1 Nobiletin and Its Colonic Metabolites Suppress Colitis-Associated Colon Carcinogenesis by Downregulating iNOS, Inducing Anti-Oxidative Enzymes and Arresting Cell Cycle Progression. X. Wu, M. Song, Z. Gao, M. Wang, F. Li, J. Zheng, H. Xiao. University of Massachusetts Amherst, Chinese Academy of Agricultural Sciences, People’s Republic of China.
8:15 435.2 Parabacteroides distasonis Attenuates Colonic Inflammation and Prevents Tumor Formation in AzoxymethaneTreated High-Fat Diet-Fed Mice. G. Koh, A.V. Kane, K. Lee, Q. Xu, X. Wu, J.B. Mason, J.W. Crott. USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Tufts Medical Center and Tufts University. 8:30 435.3 Consumption of the Total Western Diet (TWD) Enhanced and Sustained Colonic Inflammation and Promoted Colon Tumorigenesis in Mice, Which Led to Marked Changes in the Composition of the Gut Microbiome in Mice. A. Benninghoff, A. Hunter, S. Monsanto, S. Phatak, K. Hintze, R. Ward, M. Lefevre. Utah State University. 8:45 435.4 Ancestral and Multi-Generational Consumption of the Total Western Diet in Mice Promotes Colitis-Associated Colorectal Cancer in Third-Generation Offspring. S. Phatak, D. Larson, A. Hunter, C. Neal, K. Contreras, K. Pontsler, T. Armbrust, D. Rodriguez, B. Abercrombie, K. Hintze, R. Ward, A. Benninghoff. Utah State University. 9:00 435.5 Aberrant Crypt Formation Accompanies an Increase of Opportunistic Pathogens/bacteria in the Inflammatory Gut of C57BL/6 Mice Fed a High-Fat Diet. H. Zeng, S.L. Ishaq, Z. Liu, K.A. Keehr, M.R. Bukowski. Grand Forks Human Nutrition Research Center, Montana State University and University of Massachusetts. 9:15 435.6 Changes in Body Adiposity and Its Associated Inflammation Affect Metastasis of Lewis Lung Carcinoma in Mice. L. Yan, S. Sundaram. USDA ARS Grand Forks Human Nutrition Research Center. 9:30 435.7 The Influence of Genetic Ablation of Tumor Necrosis Factor-α on the Colonic Wnt Pathway Cascade Under an Obese State. Z. Liu, J. Li, A.M. Frederick, Y. Jin, X. Xu, R.J. Wood. University of Massachusetts, Amherst, Tufts University, Shengjing Hospital of China Medical University, People’s Republic of China. 9:45 435.8 Green Tea Extract Protects Against Diethylnitrosamine-Mediated Liver Injury and Cell Proliferation by Attenuating STAT3 and iNOS Expression in High Fat-Induced Obese Mice with Nonalcoholic Steatohepatitis. J.B. Kim, J. Li, C. Chitchumroonchokchai, G.Y. Sasaki, J.M. ThomasAhner, S.K. Clinton, R.S. Bruno. The Ohio State University.
436. VITAMINS AND CHRONIC DISEASE AND MICRONUTRIENT INTERVENTIONS Oral Tue. 8:00 am—McCormick Place Convention Center, S104A 8:00 436.1 Vitamin D Derived from Dietary Whole Egg Is More Effective Than Supplemental Vitamin D3 in Maintaining Vitamin D Balance in Type 2 Diabetic Rats. C.J. Saande, C.H. Reed, C.A. Coonts, K.E. Hahn, M.J. Rowling, K.L. Schalinske. Iowa State University. 8:15 436.2 Whole Egg Consumption as a Dietary Prevention and Treatment Intervention Increases Serum 25-Hydroxyvitamin D Concentrations in Rats with DSS-Induced Colitis. S.K. Jones, C.H. Reed, K.E. Hahn, C.A. Coonts, D.M. Worrall, M.J. Rowling, K.L. Schalinske. Iowa State University. 8:30 436.3 Role of Intracellular Calcium in Vitamin D-Treated L6 Myoblast Differentiation and Fiber Type Specification. M. Park, J. Kim, K. Whang. Korea University, Republic of Korea.
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NUTRITION TUESDAY 8:45 436.4 1,25-Dihydroxyvitamin D3 Mediates L6 Myoblast Differentiation via Vitamin D Receptor (VDR). M. Park, J. Kim, K. Whang. Korea University, Republic of Korea. 9:00 436.5 A Novel, High Precision Multiple-Meal Stable Isotope Method to Compare Iron Absorption from Extruded FePP-Fortified Rice Containing Different Zinc Compounds, Citric Acid/Trisodium Citrate and EDTA in Ghanaian Children. L. Hackl, A. Abizari, H. Zungbey-Garti, C. Zeder, C. Speich, C.I. Cercamondi, M.B. Zimmermann, D. Moretti. Swiss Federal Institute of Technology, Switzerland, University for Development Studies, Ghana. 9:15 436.6 Home Fortification with Multiple Micronutrient Powders Improves Infant and Young Child Development in Bihar, India. L. Larson, M. Young, P. Bauer, M. Rukshan, A. Webb Girard, U. Ramakrishnan, P. Verma, I. Chaudhuri, S. Srikantiah, R. Martorell. Emory University and CARE India, India. 9:30 436.7 early-Life Iron Supplementation Alters Whole Body Iron Homeostasis, Serum Metabolites, and Social Novelty Discrimination in Pre-Weanling Pigs. P. Ji, S. McClorry, B. Lonnerdal, C. Slupsky, K. Kim, C.N. Jinno. University of California at Davis. 9:45 436.8 Increases in Indicators of Iron, Zinc, Folate and Vitamin B12 Status in Urban Cameroon Following Wheat Flour Fortification. R. Engle-Stone, M. Nankap, A.O. Ndjebayi, L.H. Allen, S. Shahab-Ferdows, D. Hampel, D.W. Killilea, M. Gimou, L.A. Houghton, A. Friedman, A. Tarini, R. Stamm, K.H. Brown. University of California, Helen Keller International, USDA, ARS Western Human Nutrition Research Center, Children’s Hospital Oakland Research Institute, Centre Pasteur, Cameroon, University of Otago, New Zealand and Bill & Melinda Gates Foundation.
437. TRANSLATION OF NUTRITION SCIENCE AND FOOD SCIENCE AND TECHNOLOGY IN NUTRITION Oral Tue. 8:00 am—McCormick Place Convention Center, S104B
9:00 437.5 Verifying Fibers Meet Regulatory Definitions for Nutrition Facts Labeling: A Randomized, Controlled Trial Evaluating Polydextrose in Dry Form. A. Zhao, S. Rahman, E. Park, D. Xiao, I. Edirisinghe, B.B. Freeman. Illinois Institute of Technology. 9:15 437.6 Foodomics Application: Analysis of Dietary Components of the DASH Diet Pre and Post Consumption. Y. Nkrumah-Elie, R. Reisdorph, B. Tooker, M. Tang, L. O’Connor, S. Borengasser, R. Sayer, N. Krebs, W. Campbell, N. Reisdorph. University of Colorado, Anschutz Medical Campus and Purdue University. 9:30 437.7 Health Modifying Regions in the Oat (Avena sativa) Genome Responsible for Beneficial Effects on Immune and Gastrointestinal Health. W.W. Bussler, K. Dezego, M. Bowen, A. Buige, D. Esposito, M. Lila, S. Komarnytsky. Plants for Human Health Institute, North Carolina State University, North Carolina State University, Catawba College and University of North Carolina at Chapel Hill. 9:45 437.8 Differences Between Organic and Conventionally Produced Milk Reduce When Both Systems Use Pasture-Feeding. B.H. Schwendel, T.J. Wester, P.C. Morel, B. Fong, M.H. Tavendale, C. Deadman, N.M. Shadbolt, D.E. Otter. AgResearch Grasslands, New Zealand, Massey University, New Zealand, Fonterra, New Zealand and University of Wisconsin-Madison.
438. HISTORY OF NUTRITION FORUM: HISTORY OF THE DIETARY GUIDELINES FOR AMERICANS Forum Tue. 8:00 am—McCormick Place Convention Center, S105A Chaired: L. Jahns and F. Nielsen 8:00 8:25 8:50
Chaired: N. Khan and E. Radlowski 8:00 437.1 Awareness of Dietary Guidance and Diet Quality of Adults, What We Eat in America, NHANES 2007– 2012. K. Hoy, J.D. Goldman, A.J. Moshfegh. ARS-USDA. 8:15 437.2 Is the Consumption of Foods Passing Reformulation Standards Associated with the HEI-2010? G. Masset, F. Mainardi, M. Gressier. Nestlé Research Center, Switzerland and Nestlé Institute of Health Science, Switzerland. 8:30 437.3 Setting Reformulation Targets per Serving: A Global System for Sodium and Sugar Reduction and Its Applicability in the USA. A. Vlassopoulos, M. Gressier, G. Masset. Nestle Research Center, Switzerland. 8:45 437.4 Modeled Impact of Food and Beverage Reformulations on Added Sugars Intake and Its Social Gradient in the US. M. Gressier, K.C. Mathias, A. Drewnowski, A. Vlassopoulos, G. Masset. Nestlé Research Center, Switzerland and University of Washington.
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History of Federal Dietary Recommendations Prior to the Dietary Guidelines for Americans—1894–1970s. Wendy Davis. USDA ARS. Evolution of Dietary Guidelines for Americans, 1980 to 2015. Alice Lichtenstein. Tufts Univ. Challenges and Controversial issues in the Dietary Guidelines for Americans, 1980 to 2015. Marion Nestle. New York Univ. Who Uses Them, and How: Past Accomplishments and Future Methods for Reaching Targeted Audiences. Suzanne Murphy. Univ. of Hawaii at Manoa Cancer Ctr.
440. AFRICAN NUTRITION GRADUATE STUDENTS NETWORK FORUM Forum Tue. 9:00 am—McCormick Place Convention Center, S105BC Chaired: J. Ashong
TUESDAY NUTRITION
441. DIET AND EXERCISE-INDUCED EPIGENETIC ALTERATIONS OF SKELETAL MUSCLE AND WHITE, BEIGE, AND BROWN ADIPOCYTES
443. PROTEIN INTAKE AND HEALTH Oral
Symposium
Tue. 10:30 am—McCormick Place Convention Center, S102BC
(Supported by USDA Agriculture Research Service)
Chaired: J. Carbone and L. Margolis
(Sponsored by: Nutrient Gene Interactions RIS) Tue. 10:30 am—McCormick Place Convention Center, S100BC Chaired: K.J. Claycombe-Larson 10:30
Introduction and Overview. James Roemmich. USDA ARS Grand Forks Human Nutrition Research Ctr. 10:40 Control of Chromatin Architecture and Brown Fat Transcriptional Programming. Suzi Shapira. 11:05 Influence of Maternal Exercise on Offspring Skeletal Muscle and Adipose Tissue Metabolic Health and Adiposity. Kevin Pearson. Univ. of Kentucky. 11:30 Transcriptional and Epigenetic Regulation of Beige Adipocyte Epigenetic Factors by Metabolites. Shingo Kajimura. Univ. of California, San Francisco. 11:55 Maternal Under- or Over-Nutrition and Offspring Exercise Effects on Subcutaneous Adipose Tissue Programming and Obesity. Kate ClaycombeLarson. USDA ARS Grand Forks Human Nutrition Research Ctr.
442. FOOD AND NUTRITION BOARD FORUM: ASSESSING OBESITY TRENDS, MEETING THE NUTRITIONAL NEEDS OF WIC PARTICIPANTS, AND UNDERSTANDING FOOD ALLERGY: FOCUS ON CHILDREN Forum Tue. 10:30 am—McCormick Place Convention Center, S100A Chaired: A.L. Yaktine and C. Garza 10:30 Food and Nutrition Board Update. Cutberto Garza. Boston Col. 10:45 Assessing Prevalence and Trends in Obesity: Navigating the Evidence. Cheryl Anderson. Univ. of California San Diego Sch. of Med. 11:15 Updating the WIC Food Packages: Alignment with the 2015 Dietary Guidelines. Kathleen Rasmussen. Cornell Univ. 11:45 Food Allergy: A Roadmap to Safety. Virginia Stallings. Univ. of Pennsylvania.
10:30 443.1 A Pilot Study Assessing Whether the Consumption of a Protein-Rich Breakfast Improves Appetite Control, Eating Behavior, and Sleep Quality Compared to Skipping Breakfast in Healthy Young Professionals. J.A. Gwin, H.J. Leidy. Purdue University. 10:45 443.2 Even Mealtime Distribution of Protein Intake Is Associated with Greater Muscle Strength, but Not with 3-Year Decline, in Free-Living Older Adults: The Nuage Study. S. Farsijani, H. Payette, J.A. Morais, B. Shatenstein, P. Gaudreau, S. Chevalier. McGill University, Canada, University of Sherbrooke, Canada and University of Montreal, Canada. 11:00 443.3 Protein Intake in Early Childhood Is Not Associated with Adiposity, Height, or IGF-I in Mid-Childhood Among Well-Nourished Children in a U.S. Cohort. K. Switkowski, P. Jacques, A. Must, E. Oken. Harvard Medical School and Harvard Pilgrim Health Care Institute, Friedman School of Nutrition Science and Policy, Tufts University, Jean Mayer—USDA Human Nutrition Research Center on Aging, Tufts University, School of Medicine, Tufts University and Harvard School of Public Health. 11:15 443.4 Beneficial Effects of Animal and Plant Proteins on Skeletal Muscle Mass and Functional Status. L.L. Moore, M. Bradlee, M.R. Singer. Boston University School of Medicine. 11:30 443.5 Effects of Consuming Protein-Rich Supplements Between or with Meals on Changes in Body Composition with Resistance Training: A Systematic Review of Randomized Controlled Trials. J.L. Hudson, R.E. Bergia, W.W. Campbell. Purdue University. 11:45 443.6 Effects of Dietary Protein Evenly Spread Throughout the Day on Sleep and Mood in Overweight Women During Sub-Chronic Energy Balance and Energy Restriction. J.A. Gwin, H.J. Leidy. Purdue University. 12:00 443.7 Effects of Dietary Protein Source and Amount on Bone Quantity and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model of Postmenopausal Obesity. C.S. Wright, R.P. Main, W.W. Campbell. Purdue University. 12:15 443.8 Effects of a High Protein Diet with and Without a Multi-Strain Probiotic and Prebiotic on Microbiota and Gastrointestinal Wellness in Older Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. A.L. Ford, C. MacPherson, S. Girard, T.A. Tompkins, J. Tremblay, M. Christman, W.J. Dahl. University of Florida, Lallemand Health Solutions, Canada, National Research Council Canada, Canada and MCC Statistical Consulting LLC.
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444. NUTRITIONAL IMPACTS TO MICROBIOME FUNCTION Oral Tue. 10:30 am—McCormick Place Convention Center, S102D Chaired: D.A. Sela 10:30 Introduction. 10:45 444.1 Early Diet Has Differential Effects on the Small Intestine Microbiome by Region in Neonatal Piglets. B. Piccolo, A. Bowlin, M. Saraf, K. Mercer, S. Bhattacharya, S. Chintapalli, S. Adams, K. Shankar, T. Badger, L. Yeruva. Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. 11:00 444.2 Interactive Effects of Blueberry Supplementation and GPR109A Deletion on Gut Microbiome Profiles in Mice. K. Shankar, Z. Ying, L.P. Oksana, S.V. Chintapalli, J. Chen, U.D. Wankhade. University of Arkansas Medical Sciences and Arkansas Children Nutrition Center. 11:15 444.3 Prebiotics and Milk Oligosaccharides Affect Colonic Metabolome and Stressor-Induced Immunomodulation in Mice. M.T. Bailey, R.M. Jaggers, A.R. Mackos, M. Chichlowski, B. Berg. Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Mead Johnson Pediatric Nutrition Institute. 11:30 444.4 Prebiotic Enhancement of Intestinal Adaptation in Piglets with Short Bowel Syndrome Is Associated with Microbial and Enteroendocrine Modifications. B.R. Loman, K.A. Tappenden. University of Illinois Urbana-Champaign. 11:45 444.5 High Energy Expenditure and Negative Energy Balance Modulate Composition and Metabolism of the Gut Microbiota. J. Karl, L.M. Margolis, N.E. Murphy, S. Martini, Y. Gundersen, J.W. Castellani, C.T. Carrigan, H.K. Teien, E.H. Madsilen, N. Chakraborty, R. Kumar, A. Hoke, A. Gautam, R. Hammamieh, S.J. Montain, S.M. Pasiakos. US Army Research Institute of Environmental Medicine, Norwegian Defense Research Establishment, Norway, Geneva Foundation, Frederick National Laboratory for Cancer Research and US Army Center for Environmental Health Research. 12:00 444.6 Effects of the Food Matrix and Western Diet on the Mouse Microbiome. K. Hintze, T. Hisatome, S. Kellen, A. Hunter, N. Aardema, R. Ward, A. Benninghoff, M. Lefevre. Utah State University. 12:15 444.7 Effects of Storage Conditions on Gut Microbiota Data. K.Y. Sugino, S.S. Comstock. Michigan State University.
445. HEALTH DISPARITIES AND PROMOTING HEALTH IN DIVERSE POPULATIONS Oral Tue. 10:30 am—McCormick Place Convention Center, S103A Chaired: S. Colby and M.D. Teran-Garcia 10:30 445.1 Nutrient Inadequacy Among Nutritionally Vulnerable Populations in the Us. Z. Conrad, L.K. Johnson, W. Juan, J.N. Roemmich, L. Jahns. US Department of Agriculture, Agricultural Research Service, US Department of Health and Human Services and Food and Drug Administration.
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10:45 445.2 Association of Supplemental Nutrition Assistance Program Participation with Social Cohesion and Financial Worry Based on Race and Ethnicity Among U.S. Adults. M.P. Burke, E.A. Frongillo. U.S. Department of Agriculture and University of South Carolina. 11:00 445.3 Longitudinal Change in the Diet’s Monetary Value Is Associated with Its Change in Quality and Micronutrient Adequacy Among Urban Adults. M.A. Beydoun, M.T. Fanelli-Kuczmarski, J.M. Poti, A. Allen, H.A. Beydoun, M.K. Evans, A.B. Zonderman. National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, University of Delaware, University of North Carolina at Chapel Hill, Centers for Medicare and Medicaid Services (CMS), Johns Hopkins Medical Institution and Johns Hopkins University. 11:15 445.4 Extension-Delivered Diabetes Program for Rural-Residing Latinos Improves Diabetes Self-Management, Self-Efficacy and Knowledge. S.L. Francis, M. Keane. Iowa State University. 11:30 445.5 Association Between Emotional Eating and Overeating in Latinos. A.A. Lopez-Cepero, C. Frisard, S. Lemon, M. Rosal. University of Massachusetts Medical School. 11:45 445.6 A Race-Specific Interaction Between Vitamin K Status and Statin Use During Warfarin Therapy Initiation. J.M. Kelly, S.G. Harshman, C.M. Brensinger, K. Barger, S.E. Kimmel, S.L. Booth. JM USDA HNRCA Tufts University and University of Pennsylvania. 12:00 445.7 Feeding Practices and Lifestyle Changes After Migration: Perceptions of First Generation Latinas Living in an Emerging Community. M. Pineros-Leano, K. Tabb, Y. Castaneda, J.M. Liechty. University of Illinois at Urbana-Champaign. 12:15 445.8 High Prevalence of Asthma and Its Determinants Among Hispanic/Latino Children Enrolled in Michigan Migrant and Seasonal Head Start Programs. N. Farabi, S. Song, E.T. Crockett, W.O. Song. Michigan State University.
446. EPIDEMIOLOGICAL RESEARCH ADDRESSING DIET AND HEALTH OUTCOMES Oral Tue. 10:30 am—McCormick Place Convention Center, S103BC Chaired: K.M. Mangano and S. Noel 10:30 446.1 Dietary Patterns and Risk of Pancreatic Cancer: A Systematic Review. J. Zheng, M. Guinter, A. Merchant, M. Wirth, J. Zhang, R. Stolzenberg-Solomon, S. Steck. University of South Carolina and National Cancer Institute. 10:45 446.2 Evidence Mapping of Whole Grain Intervention Studies, Health Outcomes, and Reporting Practices. C.M. Sawicki, K.A. Livingston, P.F. Jacques, K. Koecher, N.M. McKeown. Tufts University, Bell Institute of Health and Nutrition and General Mills Inc. 11:00 446.3 Adherence to Sugar-Sweetened Beverages Recommendations Among Mexican Adults with Self-Reported Type 2 Diabetes. T.C. Aburto Soto, J.M. Poti, M.A. Mendez, B.M. Popkin. UNC. 11:15 446.4 Total Fluid Intake, Water and Sweet Beverages Intake: From a Median Intake to Identifying the Proportion of Individuals Potential at Risk. I. Guelinckx, M. Vecchio, E.T. Perrier, C. Morin. Danone Research, France.
TUESDAY NUTRITION 11:30 446.5 Leading Food Sources of Sodium in a Diverse Sample of Adults from Three US Metropolitan Areas. K.C. Hootman, L.M. Steffen, M.E. Cogswell, J.M. Shikany, C.D. Gardner, L.J. Harnack. University of Minnesota, Centers for Disease Control and Prevention, University of Alabama and Stanford University. 11:45 446.6 Low Sodium Intakes Are Not Associated with Lower Blood Pressure Levels Among Framingham Offspring Study Adults. L.L. Moore, M.R. Singer, M L. Bradlee. Boston University School of Medicine. 12:00 446.7 Dairy Products and Iodine-Containing Supplements Use Are Positively Associated with Iodine Status in Childbearing Age Women in the United States. M.A. Arsenault, K. Lee, W. Song. Michigan State University. 12:15 446.8 Increased Yogurt Intake Lowers Risk of Cardiovascular Disease Among Middle-Aged Adults with High Blood Pressure. J.R. Buendia, Y. Li, F.B. Hu, M. Bradlee, P.A. Quatromoni, H.J. Cabral, M.R. Singer, L.L. Moore. Boston University School of Medicine, Harvard T.H. Chan School of Public Health, Sargent College of Health and Rehabilitation Sciences, Boston University and Boston University School of Public Health.
447. NUTRITION AND CARDIOMETABOLIC HEALTH
11:45 447.6 A Traditional Korean Diet Reduced Total Blood Cholesterol and Increased Telomere Length of Peripheral Blood Cells in Perimenopausal Korean Women. P. Shin, M. Kim, H. Lee, S. Park, D. Kwon, S. Choi. CHA University, Republic of Korea, Korea Food Research Institute, Republic of Korea, Gachon University, Republic of Korea, Chaum Life Center CHA University, Republic of Korea. 12:00 447.7 Lead Exposure, Dietary Magnesium and Glucose Homeostasis in Chinese Adults. M.A. Mendez, L. Liu, S. Du, H. Wang. University of North Carolina at Chapel Hill, Beijing Municipal Center for Disease Prevention and Control, People’s Republic of China, National Institute for Nutrition and Health, and Chinese Center for Disease Control and Prevention, People’s Republic of China. 12:15 447.8 Substitution of Carbohydrate with Whole Eggs or Egg Whites Attenuates Postprandial HyperglycemiaMediated Impairments in Vascular Endothelial Function in Prediabetic Men by Limiting Lipid Peroxidation and Dysregulated Arginine Metabolism. J.D. McDonald, C. Chitchumroonchokchai, J. Li, J.S. Volek, K.D. Ballard, R.S. Bruno. The Ohio State University and Miami University.
448. MAMMARY GLAND FUNCTION AND EFFECTS OF MILK COMPONENTS ON INFANT HEALTH
Oral
Oral
Tue. 10:30 am—McCormick Place Convention Center, S103D
Maternal, Perinatal and Pediatric Nutrition RIS
Chaired: A. Basu and S.A. Johnson 10:30 447.1 A Year-Long Trial to Examine the Effects of a Daily Dose of Walnuts on Cardiometabolic Risk Markers in an Elderly Population. A. Al Abdrabalnabi, E. Bitok, S. Rajaram, N. Rizzo, J. Sabaté. Loma Linda University. 10:45 447.2 Adopting, Abandoning, and Re-Adopting Healthy Eating Patterns Sends Cardiovascular Disease Risk Factors on a Rollercoaster Ride. W.W. Campbell, L.E. O’Connor, J. Li, R.D. Sayer, A.J. Wright. Purdue University. 11:00 447.3 Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. 11:15 447.4 A Low Magnesium Diet Worsens Metabolic Disturbances and Insulin Sensitivity in Diabetic Mice. A.J. Smith, J. Challburg, A.L. O’Farrell, B. Duke, J.D. Symons, T. Jalili. University of Utah. 11:30 447.5 A 12-Week Randomised Controlled Trial to Evaluate Effects of Dietary Pulse Consumption on Cardiovascular Disease Risk Factors. A.M. Hill, P. Zahradka, A.M. Coates, P.R. Howe, C.G. Taylor, J.D. Buckley. University of South Australia, Australia, Canadian Centre for Agri-Food Research in Health and Medicine, Canada, University of Manitoba, Canada and University of Newcastle, Australia.
Tue. 10:30 am—McCormick Place Convention Center, S104A Chaired: C-E. Briere 10:30 448.1 The Role of Milk Fat Globule Membranes in Behavior and Cognitive Function Using a Suckling Rat Pup Supplementation Model. L.R. Brink, B. Lonnerdal. University of California at Davis. 10:45 448.2 Human Milk Oligosaccharides and Food Sensitization at 12 Months in the CHILD Cohort. M.B. Azad, B. Robertson, A.K. Sharma, P. Subbarao, A.B. Becker, P.J. Mandhane, S.E. Turvey, D.L. Lefebvre, M.R. Sears, L. Bode. University of Manitoba, Canada, Children’s Hospital Research Institute of Manitoba, Canada, University of California San Diego, George & Fay Yee Centre for Healthcare Innovation, Canada, University of Toronto, Canada, University of Alberta, Canada, University of British Columbia, Canada and McMaster University, Canada. 11:00 448.3 Dietary Sialyllactose Influences Magnetic Resonance Imaging Outcomes in the Piglet Corpus Callosum. A.T. Mudd, S.A. Fleming, M. Chichlowski, B.M. Berg, S.M. Donovan, R.N. Dilger. University of Illinois and Mead Johnson Pediatric Nutrition Institute. 11:15 448.4 ZnT2 Regulates Lysosomal Acidification and Biogenesis During Mammary Gland Involution. O.C. Rivera, S.R. Hennigar, S. Lee, S.L. Kelleher. Pennsylvania State University Hershey College of Medicine and Pennsylvania State University. 11:30 448.5 A Combination of Milk Fat Globule Membrane and Prebiotics Modulates Pain Hypersensitivity and Cognitive Responses to Maternal Separation Stress. R.V. Waworuntu, K.M. Neufeld, S.M. O’Mahony, M. Pusceddu, B.M. Berg, T.G. Dinan, J.F. Cryan. Mead Johnson Pediatric Nutrition Institute, APC Microbiome Institute, Ireland and University College Cork, Ireland.
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NUTRITION TUESDAY 11:45 448.6 In Vitro Supplementation of Leucine Increases Murine HC11 Cell Proliferation. M.M. McGuckin, A. Suryawan, T.A. Davis, D.G. Peterson, R. Manjarin. California Polytechnic State University and Baylor College of Medicine. 12:00 448.7 Longitudinal Study of Pesticide Residue Levels in Human Milk from Western Australia During 12-Months of Lactation: Exposure Assessment for Infants. D.T. Geddes, J. Du, M.C. Gay, Z. Gridneva, C. Lai, P.E. Hartmann, R.D. Trengove. The University of Western Australia, Australia, Murdoch University, Australia and Metabolomics Australia, Australia. 12:15 448.8 Maternal High Fat Diet Significantly Impacts Milk miRNA and mRNA Content of Lactating Mice. Y. Chen, S. Yang, J. Crodian, S. Kuang, J. Wang, M. Gribskov, K. Plaut, T.M. Casey. Purdue University and
[email protected].
452. W.O. ATWATER LECTURE Award Lecture (Sponsored by: USDA Agricultural Research Service) Tue. 1:00 pm—McCormick Place Convention Center, S100BC 1:00 Introduction. 1:05 Traveling the Road from Precision to Imprecision: Have I Gone in the Wrong Direction? Dennis Bier. USDA ARS Children’s Nutrition Research Ctr.
453. THE INTEGRATIVE PHYSIOLOGY OF A MEAL Symposium
449. HOW TO ACCESS AND USE A FIBER AND HEALTH OUTCOMES DATABASE FOR RESEARCHERS AND POLICYMAKERS Symposium (Supported by: ILSI North America) Tue. 11:00 am—McCormick Place Convention Center, S105A Chaired: N. McKeown and B. Lyle 11:15
Development of a Database on “Diet-Related Fibers and Human Health Outcomes” from 1946–2016. Kara Livingston. Tufts Univ. 11:45 Application of the “Diet-Related Fibers and Human Health Outcomes” database using Evidence Mapping Methodology. Caleigh Sawicki. Tufts Univ.
450. UNRAVELING THE COMPLEXITIES OF FOOD ALLERGY: IMPLICATIONS TO THE NUTRITIONIST, CONSUMER, AND FOOD INDUSTRY ASN Satellite (Supported by Egg Nutrition Center and the National Dairy Council) Tue. 12:45 pm—McCormick Place Convention Center, S105BCD Chaired: T. Rains and J. Nicholls 12:45 Introduction. Tia Rains. Egg Nutrition Ctr. 12:45 Introduction. Jill Nicholls. National Dairy Council. 1:00 TBD. Daniel Rotrosen. National Inst. of Allergy and Infectious Disease. 1:30 TBD. Steve Taylor. Univ. of Nebraska, Lincoln. 2:00 TBD. Virginia Stallings. Univ. of Pennsylvania.
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Tue. 3:00 pm—McCormick Place Convention Center, S100BC 3:00
Post-Meal Neurobiology. Christoph Buettner. Mt. Sinai Med. Ctr. 3:35 Post-Meal Endocrinology and GI Tract Physiology. Victoria Salem. Imperial Col. London. 4:10 Post-Meal Bioenergetics and Fuel Metabolism. Elizabeth Parks. Univ. of Missouri. 4:45 Post-Meal Hemodynamics, Platelet Reactivity and Inflammation. John Rutledge. Univ. of California, Davis.
454. DIETARY BIOACTIVE COMPONONENTS OF MEDICINAL, FUNCTIONAL AND FERMENTED FOODS Oral Tue. 3:00 pm—McCormick Place Convention Center, S102BC Chaired: A. Neilson 3:00 454.1 Beneficial Effects of Fermentation of Whole Grains (WG) and Whole Grain Resistant Starch (RS) in Lean Zucker Diabetic Fatty (ZDF) Rats. J. Guice, R. Page, D. Carvajal-Aldaz, A. Raggio, D. Obanda, H. Durham, M. Marco, G. Tuuri, R. Martin, B. Marx, D. Coulon, M. Keenan. LSU AgCenter, Facultad Ciencias de la Vida, Ecuador, University of California at Davis and LSU A&M. 3:15 454.2 Immunological Effects of Lactobacillus johnsonii N6.2 in Healthy Adults: A Double-Blind, Randomized Trial. G.L. Lorca, G. Marcial, A. Ford, S. Gezan, D. Perry, M. Haller, C. Wasserfall, T. Brusko, M. Atkinson, C. Gonzalez, W. Dahl. University of Florida. 3:30 454.3 Small Servings of Vegetables or a Cruciferous Supplement Do Not Affect Urinary Estrogen Metabolites in Premenopausal Women. S. Mondloch, C. Muir, S. Arscott, N. Binkley, S.A. Tanumihardjo. University of Wisconsin-Madison, Standard Process, Inc. 3:45 454.4 Regular Consumption of a Functional Symbiotic Yogurt Increases Calcium Absorption in Young Adult Women. R. Cornes, A. Peña, C. Sintes, S. Albin, K.O. O´Brien, C.M. Donangelo. Escuela de Nutrición, niversidad de la República, Uruguay, Division of Nutritional Sciences and Cornell University.
TUESDAY NUTRITION 4:00 454.5 Vitamin K Content of U.S. Dairy Foods and the Association with Fat Content. X. Fu, S.G. Harshman, X. Shen, D. Haytowitz, S.L. Booth. Tufts University and Beltsville Human Nutrition Research Center. 4:15 454.6 Anthocyanin Profiles and Contents in Processed Raspberries on the US Market. X. Wu, J. Sun, J. Ahuja, D.B. Haytowitz, B. Burton-Freeman, P. Chen, P.R. Pehrsson. Beltsville Human Nutrition Research Center and Illinois Institute of Technology. 4:30 454.7 Dietary Cranberry Alleviated Colonic Inflammation and Altered Gut Microbiota in Mice. X. Cai, M. Gu, M. Song, Z. Li, F. Li, T. Goulette, X. You, D.A. Sela, H. Xiao. University of Massachusetts Amherst. 4:45 454.8 improvement of Memory Impairment by Aqueous Extract of Asparagus officinalis L. is Related to Change of Intestinal Microflora in Mice. J. Sun, Z. Sui, C. Qi, Y. Huang, H. Xiao. Jiangnan University, People’s Republic of China, University of Massachusetts, Asparagus Engineering Technology Research Center of Hebei, People’s Republic of China.
455. IMPROVING THE DIETS OF VULNERABLE POPULATIONS Oral (Sponsored by: Global Nutrition Council) Tue. 3:00 pm—McCormick Place Convention Center, S102D Chaired: C. Stewart and S.L. Young 3:00 455.1 Adding a Water, Sanitation and Hygiene Intervention and a Lipid-Based Nutrient Supplement to an Integrated Agriculture and Nutrition Program Improved the Nutritional Status of Young Burkinabé Children. D.K. Olney, L. Bliznashka, E. Becquey, O. Birba, M. Ruel. International Food Policy Research Institute. 3:15 455.2 El Niño Southern Oscillation Affects Food Consumption, Intake, and Dietary Diversity in the Peruvian Amazon. R. Ambikapathi, M. Kosek, P. Yori, M. Paredes Olortegui, B. Zaitchik, G.O. Lee, A. Bauck, L. Caulfield. Johns Hopkins Bloomberg School of Public Health, Biomedical Investigations Unit AB PRISMA, Iquitos Peru., Peru, Johns Hopkins University and University of Michigan. 3:30 455.3 Association Between Household Food Insecurity and Dietary Diversity Among Pregnant and Lactating Women in Rural Malawi. Y. Kang, K. Hurley, A.B. Monclus, J. Ruel-Bergeron, R. Oemcke, L.S. Wu, M. Mitra, J. Phuka, R. Klemm, K. West, P. Christian. Johns Hopkins School of Public Health, University of Malawi, Malawi, Helen Keller International and Bill & Melinda Gates Foundation. 3:45 455.4 Risk Factors of Poor Complementary Feeding Practices in Pakistani Children Aged 6–23 Months: A Multi-Level Analysis of the Demographic and Health Survey 2012–2013. M. Na, V.M. Aguayo, M. Arimond, C.P. Stewart. University of California Davis and UNICEF.
4:00 455.5 Women’s Empowerment Is Associated with Maternal and Child Diet Diversity but Not Household Food Security in Pastoral Communities in Tanzania. A.W. Girard, I. Baltenweck, P. Dominguez-Salas, A. Galie, K. Harris, R. Jones, L. Korir, I.G. Raskind, N. Teufil, K.M. Yount. Rollins School of Public Health, Emory University, International Livestock Research Institute, Kenya, Royal Veterinary College, United Kingdom and London School of Hygiene and Tropical Medicine, United Kingdom. 4:15 455.6 Conceptualizations of Nutrition and Food Choice Behaviors Among Adolescent Girls and Young Women in Harare, Zimbabwe. C.B. Tinago, L. Annang Ingram, E.A. Frongillo, C.E. Blake, B. Engelsmann, D. Simmons. West Chester University of Pennsylvania, University of South Carolina and The Organization for Public Health Interventions and Development (OPHID) Trust, Zimbabwe. 4:30 455.7 Local Egg Production Centers Significantly Increase Maternal and Child Egg Consumption in Rural Zambia. S. Dumas, A.J. Travis. Cornell University. 4:45 455.8 Improving Children’s Diet and Nutritional Status Through an Agriculture Intervention with Nutrition Education in Upper Manya Krobo District of Ghana. G.S. Marquis, E.K. Colecraft, R. Kanlisi, C. Pinto, R. Aryeetey, B. Aidam, B. Bannerman. McGill University, Canada, University of Ghana, Ghana, Heifer Ghana, Ghana and World Vision International.
456. EARLY LIFE OBESITY: CAUSES, CORRELATIONS AND TREATMENT Oral Tue. 3:00 pm—McCormick Place Convention Center, S103A Chaired: M.I. Cardel and K. Moding 3:00 456.1 Folic Acid Content in Gestational Diet Elicits Dose-Dependent Changes on Hypothalamic Feeding Circuits in Wistar Rats at Birth. N.V. Yang, D. Chatterjee, E. Pannia, R. Kubant, G. Anderson. University of Toronto, Canada. 3:15 456.2 Both Paternal Exercise and Healthy Diet Are Required to Protect Offspring from High Fat Diet-Induced Obesity and Type 2 Diabetes Risk in Mice. K.J. Claycombe, D. Krout, R. Garcia, J. Roemmich. USDA AS GFHNRC. 3:30 456.3 Racial/Ethnic Disparities in Childhood Body Mass Index Trajectories and Potential Causes Among 29,254 US Children: The Early Childhood Longitudinal Study-Birth and Kindergarten Cohorts. Y. Wang, J. Min, X. Wen, H. Xue. Ball State University, University at Buffalo and The State University of New York. 3:45 456.4 Loss of a Healthy Weight Advantage Among Foreign-Born Children of Mexican Origin: An Analysis of Overweight/Obesity Trends from 1988–1994 to 2007–2014. L.E. Maldonado, S.S. Albrecht. University of North Carolina at Chapel Hill. 4:00 456.5 Patterns of Disordered Eating Are Associated with Weight Change in Family-Based Behavioral Obesity Treatment. K.N. Balantekin, J.F. Hayes, D.H. Sheinbein, R.P. Kolko, R.I. Stein, B.E. Saelens, R. Welch, M.G. Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley. Washington University School of Medicine, UPMC, Seattle Children’s Hospital, University of Florida and University at Buffalo.
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NUTRITION TUESDAY 4:15 456.6 Pre-Meal Television Viewing and Exercise on Subjective Appetite and Food Intake in Children. J.O. Totosy de Zepetnek, M. Da Silva, K. Miller, N. Bellissimo. Ryerson University, Canada. 4:30 456.7 Evaluation of “JenMe”, a Commercially Delivered Weight Management Program for Adolescents: A Randomised Controlled Trial. M.P. Bonham, A.L. Dordevic, R.S. Ware, H. Truby. Monash University, Australia, Menzies Health Institute Queensland, Griffith University, Australia and University of Queensland, Australia. 4:45 456.8 Changes in Lean Mass and Bone Parameters in Obese Children Participating in a Family-Centered Lifestyle Intervention: Results from a 1-Year RCT. T.R. Cohen, T.J. Hazell, C.A. Vanstone, C. Rodd, H.A. Weiler. McGill University, Canada, Wilfrid Laurier University, Canada and University of Manitoba, Canada.
457. MATERNAL FACTORS RELATED TO PREGNANCY, LACTATION AND INFANT HEALTH Oral
458. NONALCOHOLIC FATTY LIVER DISEASE AND LIVER METABOLISM Oral (Sponsored by: Medical Nutrition Council)
Maternal, Perinatal and Pediatric Nutrition RIS
Tue. 3:00 pm—McCormick Place Convention Center, S103D
Tue. 3:00 pm—McCormick Place Convention Center, S103BC
Chaired: S. Raatz
Chaired: S. Sen and K. Raghavan 3:00 457.1 Are You What Your Mother Ate: Maternal Artificially-Sweetened Beverages Intake During Pregnancy and Offspring Growth and Obesity Through Age 7 Years? Y. Zhu, S.F. Olsen, P. Mendola, T.I. Halldorsson, S. Rawal, S.N. Hinkle, E.H. Yeung, J.E. Chavarro, L.G. Grunnet, C. Granström, A.A. Bjerregaard, F.B. Hu, C. Zhang. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Kaiser Permanente Northern California, Statens Serum Institut, Denmark, University of Iceland, Iceland, Harvard T.H. Chan School of Public Health and Rigshospitalet University Hospital, Denmark. 3:15 457.2 Untargeted Metabolomics Reveal Disparate Metabolite Profile in Follicular Fluid Between Obese and Normal Weight Women. M.L. Ruebel, B.D. Piccolo, D.M. Moutos, K. Shankar, A. Andres. Arkansas Children’s Nutrition Center, Michigan State University, University of Arkansas for the Medical Sciences and Arkansas Fertility & Gynecology. 3:30 457.3 Plasma Alpha-Linolenic and Linoleic Acids in Early Pregnancy Are Associated with Birth Outcomes in Rural Malawi. B.M. Oaks, K.G. Dewey, K. Maleta, J.R. Sadalaki, U. Ashorn, W.S. Harris, P. Ashorn. University of California, University of Malawi College of Medicine, Malawi, University of Tampere School of Medicine, Finland, OmegaQuant Analytics, LLC and Tampere University Hospital, Finland. 3:45 457.4 Factors Shaping Breastfeeding Support Benefits in Workplaces: Perspectives of Human Resources Managers. A.L. MacMillan Uribe, T.A. Bolton, K. Woelky, B.H. Olson. University of Wisconsin-Madison and Ingham County Health Department. 4:00 457.5 Administration of Fluoxetine or a Small Molecule TPH1 Inhibitor Affects Litter Size, Pup Mortality, and Milk Yield During Murine Pregnancy and Lactation. S. Weaver, H. Fricke, L. Hernandez. University of Wisconsin-Madison.
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4:15 457.6 Milk Cell Gene Expression of Mothers with Low Breast Milk Production. D.T. Geddes, A. Twigger, D.L. Savigni, J.C. Kent, F. Kakulas. The University of Western Australia, Australia. 4:30 457.7 Impact of the Lactation Advice Through Texting Can Help (LATCH) Randomized Controlled Trial. J.L. MartinezBrockman, N. Harari, S. Segura-Perez, L. Goeschel, R. Perez-Escamilla. Yale University, Indian Health Service, Hispanic Health Council and CT Department of Public Health. 4:45 457.8 Novel Plasma Proteins in Nepalese SchoolAged Children Are Associated with a Small Head at Birth. S. Lee, K.P. West, R.N. Cole, K. Schulze, J.D. Yager, J. Groopman, P. Christian. Johns Hopkins Bloomberg School of Public Health and Johns Hopkins School of Medicine.
3:00 State of the Art Lecture. 3:30 458.1 Ablation of Systemic SIRT1 Activity Promotes Nonalcoholic Fatty Liver Disease by Affecting Liver-Mesenteric Adipose Tissue Fatty Acid Mobilization. J. Cheng, C. Liu, K. Hu, A. Greenberg, D. Wu, L.M. Ausman, M.W. McBurney, X. Wang. JM USDA-HNRCA at Tufts University, Tufts University Friedman School of Nutrition Science and Policy, Friedman School of Nutrition and Policy, Tufts University, University of Ottawa, Canada and Ottawa Hospital Research Institute, Canada. 3:45 458.2 Decaffeinated Green Tea and Voluntary Exercise Prevent Non-Alcoholic Fatty Liver Disease in Mice. W.Y. Khoo, S. Huang, B.J. Chrisfield, S. Sae-tan, J.D. Lambert. Penn State University and Kasetsart University, Thailand. 4:00 458.3 Role of Hepatic PLIN2 and PLIN4 in the Development of Western Type Diet Induced Hepatosteatosis. J.D. Griffin, D.M. Salter, T. Bowman, A. Greenberg. Tufts University. 4:15 458.4 Blackcurrant (Ribes nigrum) Consumption Prevents Non-Alcoholic Steatohepatitis in C57BL/6J Mice with Diet-Induced Obesity. Y. Lee, T.X. Pham, M. Bae, S. Hu, E. O’Neill, C. Han, C. Caceres, Y. Park, J. Lee. University of Connecticut. 4:30 458.5 Nicotinamide Riboside, an NAD+ Precursor, Attenuates the Activation of Hepatic Stellate Cells. T.X. Pham, M. Bae, J. Lee. University of Connecticut. 4:45 458.6 Biological Mediators Predict Liver Fibrosis Progression over Time in an HIV Mono-Infected Cohort. T. Stewart, A. Campa, S. Sales-Martinez, J. Hernandez Boyer, W. Wu, J. Liuzzi, M. Baum. University of Notre Dame and Florida International University.
TUESDAY NUTRITION
459. MICRONUTRIENT BIOAVAILABILITY, ANTIOXIDANT FUNCTION, ZINC, SELENIUM Oral Tue. 3:00 pm—McCormick Place Convention Center, S104A 3:00 459.1 Iron Absorption from Iron-Enriched Aspergillus oryzae Is Similar to Ferrous Sulfate in Humans. M.B. Reddy, S.M. Armah, J. Stewart, Y. Bian, A. Bries, K.O. O’Brien. Iowa State University, University of North Carolina Greensboro, Cura Global Health, Inc, and Cornell University. 3:15 459.2 Twenty-Four-Hour Urine Phosphorus Is Highly Variable in Patients with Moderate Chronic Kidney Disease on a Controlled Phosphorus Intake. E.R. Stremke, L.D. McCabe, G.P. McCabe, B.R. Martin, M. Wastney, S.M. Moe, C.M. Weaver, M. Peacock, K.M. Hill Gallant. Purdue University and Indiana University School of Medicine. 3:30 459.3 Metallothionein-2A mRNA in Peripheral Blood Mononuclear Cells Reflects Dietary Zinc Intake in Healthy Adults. S.R. Hennigar, J.P. Karl, A.M. Kelley, B.J. Anderson, N.J. Armstrong, H.L. McClung, C.E. Berryman, J.P. McClung. U.S. Army Research Institute of Environmental Medicine and Oak Ridge Institute for Science and Education. 3:45 459.4 Supplemental Zinc Decreases Fractional Zinc Absorption and Increases Lean Tissue Mass Among Vietnamese Children with Tuberculosis. A.G. Hall, N.T. Hoang, V.T. Hoang, L. Woodhouse, N. Tu, J.C. King, P.H. Vo. University of California at Davis, National Institute of Nutrition, Vietnam, National Lung Hospital, Vietnam, Western Human Nutrition Research Center, Children’s Hospital Oakland Research Institute and Institute for Nuclear Science and Technology, Vietnam 4:00 459.5 ZIP14 (SLC39A14) Is Required for Suppression of Apoptosis and Hepatic Steatosis Induced by ER Stress in Mouse Liver. M. Kim, T.B. Aydemir, J. Kim, R.J. Cousins. University of Florida. 4:15 459.6 Differential Regulation of Transcriptional Factors of Selenoprotein Genes by Moderately High Dietary Concentrations of Se and Fat in Liver and Adipose Tissue of Wildtype and Gpx1/Mice. Z. Zhao, J. Zhou, X. Lei. Cornell University. 4:30 459.7 Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice. W. Cheng, R.T. Wu, L. Cao, K.W. Witwer, H. Lu. Mississippi State University, University of Maryland at College Park and Johns Hopkins University. 4:45 459.8 The SELENOF Selenoprotein Localizes to the Outer Plasma Membrane in Human Prostatic Tissue and Its Levels Are Reduced in Prostate Cancer. D. Ekoue, E. Ansong, V. Macias, R. Deaton, A. Kajdacsy-Balla, L. Liu, C. Latcher, M. Picklo, L. Nonn, P. Gann, V. Freeman, A. Diamond. University of Illinois at Chicago and Grand Forks Human Nutrition Reseach Center.
460. NUTRIENT NEEDS/IMPACT ON AGING AND HEALTH Oral
3:15 460.2 Multiple Micronutrient Deficiencies Exist in Aged-Care Residents, with Serum Zinc, Not Iron, Being a Major Predictor of Anemia. S. MacDonell, J. Miller, M. Harper, M. Reid, J. Haszard, R. Gibson, L. Houghton. University of Otago and New Zealand, New Zealand. 3:30 460.3 Nutritional Supplementation with Physical Activity Improves Muscle Composition in Mobility-Limited Older Adults, the VIVE2 Study: A Randomized, Double-Blind, Placebo-Controlled Trial. D. Englund, D. Kirn, A. Koochek, T. Travison, K. Reid, Å. von Berens, H. Zhu, M. Lilja, T. Gustafsson, T. Cederholm, R. Fielding. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden, Institute for Aging Research, Hebrew SeniorLife, Department of Laboratory Medicine and Karolinska Institutet, Sweden. 3:45 460.4 The Effects of Iron Status on Testosterone Biosynthesis and Testicular Antioxidant Capacity in Male Rats. C. Tsao, Y. Liao, Y. Liew, Y. Lin, Y. Hsu, C. Liu. Tri-Service General Hospital, National Defense Medical Center, Taiwan and Fu Jen Catholic University, Taiwan. 4:00 460.5 α-Tocopherol—A Systematic Review of Intake and Status Globally. M. Eggersdorfer. DSM Nutritional Products, Switzerland. 4:15 460.6 Serum 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in US Adults: A Nationwide Population-Based Study. W. Bao, J.J. Oleson, L.G. Snetselaar. University of Iowa. 4:30 460.7 Elevated Levels of Circulating γ-Tocopherol as a Surrogate Marker of Mortality Risk in Populations of Adult Men Stratified by Health Index Score. R.V. Cooney, J.C. Wagner. University of Hawaii at Manoa. 4:45 460.8 N-3 Polyunsaturated Fatty Acids Increase Hepatic Fibroblast Growth Factor 21 Sensitivity Through PPARγ-β-klotho Pathway. W. Ling, W. Yang. Sun Yat-sen University, People’s Republic of China.
461. INTERNATIONAL COLLEGES FOR ADVANCEMENTS OF NUTROLOGY FORUM Forum Tue. 3:00 pm—McCormick Place Convention Center, S105A Chaired: S. Giorelli 3:00 3:20 3:40 4:00
Coffee’s Role as Functional Food and Medicinal Herb. Marcella Garcez Duarte. International Col. for Advancements of Nutrology. Obesity and Epigenetics. Rita Raman. Univ. of Oklahoma Health Sciences Ctr. Nutritional Support in Post-Bariatric Patients. Amy Ferreira Heyn. International Col. for Advancements of Nutrology. Sleep Deprivation and Obesity. Paulo Giorelli. International Col. for Advancements of Nutrology.
Tue. 3:00 pm—McCormick Place Convention Center, S104B Chaired: C.C. Sceppa and S.C. Chai 3:00 460.1 Prefrontal Cortex Structure Mediates the Relationship Between Plasma Phospholipid Stearidonic Acid and Fluid Intelligence in Healthy, Older Adults. M.K. Zamroziewicz, E.J. Paul, C.E. Zwilling, T. Das, S. Pereira, A.K. Barbey. University of Illinois Urbana-Champaign and Abbott Nutrition.
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Pathology 462. DISEASES OF THE ENDOPLASMIC RETICULUM Symposium Tue. 8:30 am—McCormick Place Convention Center, W179B
464. STOWELL SYMPOSIUM: TRENDS IN EXPERIMENTAL PATHOLOGY: GONE WITH THE WNT: A CLASSIC TALE OF STEM CELLS, CANCER AND MORE Symposium
Chaired: J. Lin and F. Urano Neuropathology
(Supported by an unrestricted educational grant from The Robert E. Stowell Endowment Fund)
Cell and Tissue Injury
Tue. 8:30 am—McCormick Place Convention Center, W180
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ER Stress in Human Photoreceptor Diseases. J. Lin. UCSD. 9:05 Podocyte ER Stress and Podocytopathies. Y. (Maggie) Chen. Washington Univ. Sch. of Med. 9:30 Insulin Gene Mutations. L. Philipson. The Univ. of Chicago. 10:05 Wolfram Syndrome, A Prototype of ER Stress-Mediated Beta Cell Death and Neurodegeneration. F. Urano. Washington Univ. Sch. of Med. 10:35 Progranulin: Connecting ER Stress and Lysosomal Protein Degradation in the Pathogenesis of Neurodegenerative Disease. A. Kao. UCSF. 11:00 ER Stress in the Inner Ear. M. Lesperance, Jochen Schacht. Univ. of Michigan, Univ. of Michigan.
463. SIPMET SYMPOSIUM: METABOLISM AND PREVENTION OF DISEASE Symposium (Sponsored by: Sponsored by ASIP and the Società Italiana di Patologia e Medicina Traslazionale /Italian Society of Pathology and Translational Medicine) Tue. 8:30 am—McCormick Place Convention Center, W181A Chaired: M. Corsi Romanelli Cardiac Pathobiology 8:30
Intestinal Microbiota: A NewEffective Actor Usually Unconsidered for the Prevention of Cancer. V. Castronovo. Univ. de Liege. 9:30 Heart Failure: Inflammasome, Necrosome and Signalosome. M. Willis. Univ. of North Carolina at Chapel Hill. 10:30 Epicardial Fat: From Biomolecular Aspects to Clinical Practice. M. Corsi Romanelli. Univ. of Milan.
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Chaired: S.P. Monga and D. Stairs Immunopathology Neoplasia 8:30
Wnt Signaling in Mensenchymal Stem Cells. T-C. He. The Univ. of Chicago Med. Ctr. 9:00 Enabling Developmental Competency to Pluripotent Stem Cells by Epigeneticaly Redirecting the Response to Wnt Signaling. B. Merrill. Univ. of Illinois at Chicago. 9:30 Control of T cell Development by Tcf-1 and ’-Catenin. F. Gounari. Univ. of Chicago. 10:00 Role of APC Defects and Beta-Catenin/TCF Dysregulation in Colon Cancer. E. Fearon. Univ. of Michigan. 10:30 The Effects of P120ctn on B-Catenin and Wnt Signaling In Head & Neck and Esophageal Squamous Cancers. D. Stairs. Penn State College of Med. 11:00 Wnt Signaling in Skeletal Disease. B. Williams. Van Andel Res. Inst.
465. REGULATION OF EPITHELIAL BARRIER INTEGRITY AND REPAIR Minisymposium Tue. 8:30 am—McCormick Place Convention Center, W181B Chaired: J. Waschke and J. Brazil Immunopathology Epithelial and Mucosal Pathobiology 8:30 465.1 Different Signaling Patterns Contribute to Loss of Keratinocyte Cohesion Dependent on Autoantibody Profile in Pemphigus. E. Walter, D. Egu, F. Vielmuth, L. Rotkopf, V. Spindler, J. Waschke. Ludwig-MaximiliansUniversität, Germany. 8:45 465.2 Intestinal Mucosa Pro-Repair Properties of Macrophage Derived IL-10 Are Mediated by CREB Triggered Epithelial WISP-1 Signaling. M. Quiros, H. Nishio, P.A. Neumann, G. Leoni, V. Garcia-Hernandez, D. Siuda, M. Feng, G. Bernal, R. Hilgarth, H. Williams, J.C. Brazil, P.H. Dedhia, J. Spence, C.A. Parkos, T.L. Denning, A. Nusrat. University of Michigan, Universität München, Germany, Institute for Cardiovascular Prevention, Germany, Emory University and Georgia State University.
TUESDAY PATHOLOGY 9:00 465.3 Adducin Regulates Migration and Invasion of Normal Lung Epithelial Cells and Lung Cancer Cells. S. Lechuga, P.H. Amin, A.I. Ivanov. Virginia Commonwealth University. 9:15 465.4 Desmoglein 2 Regulates the Intestinal Epithelial Barrier via p38 Mitogen-Activated Protein Kinase. H. Ungewiß. Institute of Anatomy and Cell Biology and LMU Munich, Germany. 9:30 465.5 Glial Cell-Line Derived Neurotrophic Factor Attenuates Inflammation-Induced Breakdown of Intestinal Epithelial Barrier Function by Stabilization of Dsg2-Dependent Intercellular Adhesion. M. Meir, N. Burkard, S. Flemming, C. Germer, J. Waschke, N. Schlegel. University Hospital Würzburg, Germany, University of Michigan and LudwigMaximilians-Universität München, Germany. 9:45 465.6 Synergistic Effects of Platelet Activating Factor and TNF-α in Promoting Intestinal Epithelial Migration and Mucosal Wound Repair. D. Siuda, M. Quirós, M. O´Leary, J. Brazil, B. Hinrichs, A. Neish, C. Parkos, A. Nusrat. University of Michigan and Emory University. 10:00 465.7 Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa to Inhibit Epithelial Wound Healing. R. Sumagin, A. Finkielsztein, T. Slater, L. Lorraine Mascarenhas, L. Mehl, V. Butin-Israeli. Northwestern University. 10:15 465.8 Desmoglein-2 Intracellular Cleavage and Intestinal Epithelial Barrier Compromise. M. Yulis, M. Quiros, R. Hilgarth, A. Nusrat. University of Michigan. 10:30 465.9 I tryptophan Metabolite Activation of the Aryl Hydrocarbon Receptor in Intestinal Epithelia Promotes Mucosal Healing. J.M. Lanis, E. Alexeev, S. Colgan. University of Colorado- Anschutz Medical Campus. 10:45 465.10 Desmoglein 2 Regulates Pancreatic Cancer Cell Migration Through Modulation of cAMP Levels. J. Zeiler, L. Sachs, V. Spindler. Ludwig-Maximilians-Universität München, Germany. 11:00 465.11 Hypoxia Inducible Factor (HIF)-1 Accelerates Epithelial Wound Healing Through Integrin Regulation. B.J. Goggins, K. Minahan, N. Outteridge, D. Knight, J. Horvat, S. Keely. University of Newcastle, Australia and Hunter Medical Research Institute, Australia. 11:15 465.12 Loss of Keratins Mimics p38MAPK-Mediated Pathogenic Effects of Autoantibodies in Pemphigus. F. Vielmuth, E. Walter, F. Loschke, T.M. Magin, V. Spindler, J. Waschke. Ludwig-Maximilians-Universität München, Germany and Leipzig University, Germany.
466. SCIENTIFIC SLEUTHING OF HUMAN DISEASE FOR UNDERGRADUATE STUDENTS AND HIGH SCHOOL TEACHERS AND STUDENTS Special Session (Sponsored by: Sponsored by the ASIP Education Committee) Tue. 9:30 am—Hyatt Regency McCormick Place, Regency Ballroom CD Chaired: K. Nejak-Bowen and M. Furie Pulmonary Pathobiology Immunopathology Neoplasia 9:30
10:00 Welcome and Introductions. K. Nejak-Bowen. Univ. of Pittsburgh. 10:20 Menacing Microbes: Emerging Infectious Diseases. M. Furie. Stony Brook Univ. 11:20 Smoking-Related Lung Disease in 3D: Not Your Standard Lecture. D. Zander. Pennsylvania State College of Med. 12:15 Stem Cells: A Case of Dr. Jekyll and Mr. Hyde. S.P. Monga. Univ. of Pittsburgh. 1:15 Tour the Exhibits at the McCormick Place Convention Center.
467. SOCIETY OF TOXICOLOGIC PATHOLOGY SYMPOSIUM: CHALLENGES IN TRANSLATION: CARDIOVASCULAR MODELING AS AN EXEMPLAR FOR IN VITRO TO IN VIVO EXTRAPOLATION Symposium (Sponsored by: ASIP Environmental and Toxicologic Scientific Interest Group and the Society of Toxicologic Pathology)
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Tue. 2:00 pm—McCormick Place Convention Center, W181A Chaired: E. Galbreath Cardiac Pathobiology Environmental and Toxicologic Pathology 2:00
Regulatory Genetic Variation Associated with Human Diseases. G. Gintant. AbbVie. 3:00 Predicting the Patient-Specific Cardiovascular Risk of Anti-Cancer Agents using hiPSC. P. Burridge. Northwestern Univ. 4:00 Integrated Strategies for Clinical Cardiovascular Risk Assessment in Nonclinical Studies. B. Berridge. GlaxoSmithKline.
468. TARGETING TRANSCRIPTION REGULATION IN DISEASE Symposium (Sponsored by: Sponsored by the Gene Expression Scientific Interest Group) Tue. 2:00 pm—McCormick Place Convention Center, W180 Chaired: P. Iannaccone, Q. Yan and D. Williams Gene Expression 2:00 Mitochondrial Gene Expression in Disease. G. Shadel. Yale Sch. of Med. 2:30 468.1 Histone Demethylase KDM5B Is Critical for PI3K-AKT-mTOR Signaling and Stemness of Melanoma. Q. Yan, S. Zhang, K. Meeth, G. Micevic, M. Bosenberg. Yale School of Medicine. 2:45 lncRNA Regulation of Gene Expression in Fate Specification and Disease. J. Kohtz. Northwestern Univ. 3:15 468.2 Epigenetic Re-Programming of Breast Cancer by Pharmacological Targeting of C-Terminal Binding Protein. J.S. Byun, K.L. Gardner. NIH.
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PATHOLOGY TUESDAY 3:30 Regulatory Genetic Variation Associated with Human Diseases. M. Nobrega. The Univ. of Chicago. 4:00 468.3 Dna Methylation, Hydroxymethylation and Formylation in Human Frontal Cortex of Autistic and Schizophrenic Subjects. M. Trivedi, R. Deth, Y. Zhang, H. Abdolmaleky. Nova Southeastern University, Northeastern University and Boston University. 4:15 Exploring the Methyl-Cytosine Binding Domain Family as Potential Therapeutic Targets. D. Williams. Univ. of North Carolina.
469. MUCOSAL INFLAMMATION AND EPITHELIALLEUKOCYTE INTERACTIONS Minisymposium Tue. 2:00 pm—McCormick Place Convention Center, W179B Chaired: S.P. Colgan and S. Keely Epithelial and Mucosal Pathobiology Immunopathology Inflammation 2:15 469.2 Novel Role of Lewis a Glycans in Regulating Neutrophil Trafficking. J.C. Brazil, R. Sumagin, G. Lee, N.A. Louis, R.D. Cummings, C.A. Parkos. University of Michigan, Northwestern University, University of Ottawa, Canada, Emory University and Beth Israel Deaconess Medical Center. 2:30 469.3 Gut Microbial Metabolites Establish a Gradient of Extracellular Protons, Which Mediate Microbiota-Stimulated Intestinal Repair via Proton-Sensing G-Protein CoupledReceptors. M. Alam, H. Wu, J. Matthews, B. Saeedi, R. Jones, A.S. Neish. Emory University School of Medicine. 2:45 469.4 Selective Intestinal Epithelial Loss of Junctional Adhesion Molecule-A Results in Enhanced Intestinal Permeability and Increased Susceptibility to Colitis. S. Flemming, A. Luissint, A. Nusrat, C.A. Parkos. University of Michigan Medical School. 3:00 469.5 The Influence of ENPP1 Expression in Mucosal Tissues. V. Curtis, R. Wang, K. Battista, J.S. Lee, S. Colgan. University of Colorado Anschutz Medical Campus. 3:15 469.6 CD47 Regulates CDd11b-Dependent Neutrophil Transepithelial Migration During Intestinal Inflammation. V. Azcutia, A. Luissint, S. Flemming, M. Quiros, A. Nusrat, F.W. Luscinskas, C.A. Parkos. University of Michigan and Brigham and Women’s Hospital and Harvard Medical School. 3:30 469.7 Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Efferocytosis by Porcine Macrophages and Modulation of Lipid Mediators of Inflammation in Vitro: A New Class of Anti-Microbial with Anti-Inflammatory and Pro-Resolution. R. Moges, D. Desmonts de Lamache, G.P. Muench, E.M. Abbott, A.G. Buret. University of Calgary, Canada and ECO Animal Health London, United Kingdom. 3:45 469.8 Increased Intestinal Permeability Secondary to Junctional Adhesion Molecule-A Deficiency Results in Impaired Macrophage-Dependent Neutrophil Recruitment in a Zymosan Peritonitis Model. A. Luissint, H.C. Williams, W. Kim, R.S. Hilgarth, M. O’Leary, S. Flemming, M. Reed, T.L. Denning, A. Nusrat, C.A. Parkos. University of Michigan, Emory University School of Medicine, Kyung Hee University, Republic of Korea, and Institute for Biomedical Sciences.
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4:00 469.9 Microbiota-Derived Tryptophan Metabolites Provide a Novel Pathway for Regulation of Mucosal Barrier Function. E.E. Alexeev, J.M. Lanis, D.J. Kao, K.D. Battista, C.J. Kelly, E.L. Campbell, D.J. Kominsky, S.P. Colgan. University of Colorado, Anschutz Medical Campus and Montana State University. 4:15 469.10 Neutrophils Induce Pro-Angiogenic T Cells with a Regulatory Phenotype in Pregnancy. S. Nadkarni, J. Smith, A. Sferruzzi-Perri, M. Kishore, C. Mauro, D. Williams, F. Marelli-Berg, M. Perretti. Queen Mary, University of London, United Kingdom, Cambridge University, United Kingdom and University College London, United Kingdom. 4:30 469.11 Intestinal P-Glycoprotein Exports Endogenous Cannabinoids at the Epithelial Surface to Prevent Inflammation and Maintain Homeostasis. R.L. Szabady, R.J. Mrsny, B.A. McCormick. UMass Medical School and University of Bath, United Kingdom. 4:45 469.12 Lack of NF-κB-Inducing Kinase (NIK) Results in Eosinophilic Esophagitis (EoE) and Gastric Hyperplasia in Mice: Implications for Noncanonical NF-κB Signaling in Human EoE. K. Eden, D.K. McDaniel, B. Heid, I.C. Allen. Virginia Maryland College of Veterinary Medicine.
470. CELL INJURY, AUTOPHAGY, AND DNA DAMAGE Minisymposium Tue. 2:00 pm—McCormick Place Convention Center, W181B Chaired: T. LaBranche and C. Yates Cell and Tissue Injury Cell Death 2:00 470.1 Autophagy Regulates Hepatocellular Senescence. N. Huda, B. Khambu, X. Chen, X. Yin. Indiana University School of Medicine. 2:20 470.2 Neuregulin-1β Induces Erbb3-Dependent Proliferation and Survival of Normal Human Cardiac Ventricular Fibroblasts. C.L. Galindo, A. Kirabo, M. Gupte, S. Ryzhov, D.B. Sawyer. Vanderbilt University Medical Center and Maine Medical Research Center. 2:40 470.3 The Nrf2 Transcription Factor Promotes Efferocytosis by Activating Phosphatidyl Serine Receptor Tim-4 Signaling During Oxidant-Induced Lung Injury Repair. N.M. Reddy, C.R. Tamatam, S.P. Reddy. University of Illinois at Chicago. 3:00 470.4 Palmitate Increases Ubiquitination in H4IIE and Primary Rat Hepatocytes. C.M. Stewart, A.L. Estrada, P.Y. Kim, D. Wang, Y. Wei, M. Pagliassotti. Colorado State University and Grambling State University. 3:20 470.5 Function of TGF-β Regulated NcRNAas in Cardiac Hypertrophy. X.Yang. Beijing Institute of Biotechnology, People’s Republic of China. 3:40 470.6 Quantitative Real Time PCR (qRT-PCR) Evaluation of Pig Mitochondrial DNA Damage. J.L. Barr, T.W. Thomas, R.S. Gibson, M.A. Dubick, P.D. Bowman. US Army Institute of Surgical Research. 4:00 470.7 Diesel Exhaust Particle Exposure Compromises Macrophage Mitochondrial Physiology. J. Gibbs, B. Dallon, J. Lewis, J.S. Tessem, P.R. Reynolds, B.T. Bikman. Brigham Young University and Brigham Young University.
TUESDAY PATHOLOGY 4:20 470.8 Initial Autophagic Protection Switches to Disruption of Autophagic Flux by Lysosomal Instability During Cadmium Stress Accrual in Renal NRK-52E Cells. F. Thevenod, W. Lee, M.P. Santoyo-Sánchez, S. Probst, E. Kerek, E.J. Prenner. University of Witten/Herdecke, Germany and University of Calgary, Canada. 4:40 470.9 Pyruvate Dehydrogenase Kinase 4 Deficiency Induces Hepatic Apoptosis by Activating NF-κB/TNFα Signaling. J. Wu, J. Choiniere, M. Lin, L. Wang. University of Connecticut, Wenzhou Medical University, People’s Republic of China, Veterans Affairs Connecticut Healthcare System and Yale University.
471. CLUB HEPATOMANIA (LIVER PATHOBIOLOGY) SCIENTIFIC INTEREST GROUP NETWORKING SESSION Special Session
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472. SCIENTIFIC INTEREST GROUP POSTER DISCUSSION AND NETWORKING SESSION Poster Discussion Tue. 5:30 pm—McCormick Place Convention Center, W375B P1
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Adjuvant Statin Therapy Efficacy Is Dictated by Tumor Dormancy and Statin Lipophilicity in ex Vivo and in Vivo Models of Metastatic Breast Cancer. C.H. Beckwitt, A.M. Clark, K. Warita, Z.N. Oltvai, A. Wells. University of Pittsburgh and Tottori University, Japan. (807.13) 3,4,2,4 Tetrahydroxychalcone (Butein) Inhibition of TNFα-Induced CCL2 Release in Triple Negative Breast Cancer Cells. A.C. Horton, D.F. Bauer, K.F. Soliman. Florida A&M University. (809.1) MiR-105/93-3p Promotes Metastasis, Chemoresistance and Stemness in TNBC and Circulating miR105/93-3p Act as Predictive Biomarker for TNBC Chemoresistance. H. Li, P. Lu. National Cheng Kung University, Taiwan. (809.2) Apigenin Modulation of Whole Transcriptome Patterns of TNFα-Induced Changes in Triple Negative Breast Cancer Cells, MDA-MB-231. D. Bauer, E. Mazzio, K.F. Soliman. Florida A&M University. (809.3)
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Quercetin Inhibition of TNFα-Induced CCL28 Release from Human Triple Negative Breast Cancer (MDAMB-468) Cells. T.F. Buchanan, D. Bauer, K.F. Soliman. Florida A&M University. (809.4) Exploring Molecular and Morphological Relationships Between Obesity and Ctbp in Breast Cancer. S. Park, T. Yan, L. Crawford, D. Li, A. Jones, A. Caban, S. Gil-Hernandez, M. Kabbout, D. Yi, S. Ambs, V. Periwal, J. Byun, K. Gardner. NCI, NIMHD and NIDDK. (806.6) Glutamine Transporter Expression Profiling in Murine Breast Cancer Reveals Therapeutic Targets for Triple Negative Breast Cancer. C. Kron, B. Bode. Northern Illinois University. (809.6) Enlarged Endosomes and Altered Transferrin Recycling in Breast Cancer Cells. K.E. Tubbesing, A. Malhotra, A. Rudkouskaya, M. Barroso. Albany Medical College. (809.11) Knockout of the PHLDA1 Gene in Breast Cancer Cells Reveals Multiple Roles for PHLDA1 in Cancer Phenotypes. A.M. Zimnicka, T. Sharma, M. Regan, B.J. Merrill, J. Frasor. University of Illinois at Chicago. (178.8) Hypoxia Stimulates an Increase of Neuropeptide Y Y1 and Y5 Receptor Expression in Human Breast Cancer Cells. P.J. Medeiros, J. Uniacke. University of Guelph, Canada. (809.12) Exploring the Relationship Between Kaiso and C-Terminal Binding Protein in Breast Cancer in Women of African Ancestry. A.B. Caban-Ureña, A. Jones, J. Shin, S. Park, S. Gil-Hernández, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. (809.9) C-Terminal Binding Protein and Snail: Understanding the Roles of Metabolic Imbalance and EMT in Breast Cancer Disparities. A. Jones, A. Caban-Ureña, S. Park, S. Gil-Hernández, J. Shin, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. (806.5) Alcohol Abuse Promotes Breast Cancer Development and Progression via StarD10 Phosphorylation. A. Floris, C. Cossu, Y. Spissu, M. Tomasi. Cedars-Sinai Medical Center. (806.2) Uncoupling Effects of ERα on LKB1/AMPK Signaling Induced by Adiponectin in Breast Cancer Cells. L. Mauro, G.D. Naimo, L. Gelsomino, E. Spina, M.L. Panno, S. Andò. University of Calabria, Italy. (809.14) Induction of Paclitaxel Resistance in Human Breast Cancer Cell by JNK/SAPK-Inhibitory Kinase Through MAPK14/RELA/PTGS2 Signaling. T. Lai. Genomics Research Center and Academia Sinica, Taiwan. (809.10) Mangenese Superoxide Dismutase (MnSOD) Promotes Stem-Like Cell Phenotypes in Breast Cancer. C. He, P. Hart, K. Fricano, M. Vargas, K. Thieraud, A. Luelsdorf de Abreu, M. Bonini University of Illinois at Chicago. (809.15)
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The Role of Metastasis-Associated Protein 1 (MTA1) in Breast Cancer Exosome-Mediated Intercellular Communication. B.N. Hannafon, K. Gaskill, C. Calloway, W. Ding. University of Oklahoma Health Sciences Center. (178.6) Three-Dimensional Histochemistry and Imaging of Extracellular Matrix-Rich Human Tissues. C.J. Van Noorden. Academic Medical Center, Netherlands. (980.5) Pulsed-Wave Doppler Blood Flow Through the Pulmonary Trunk as a Valuable Method to Determine Cardiac Output Following Myocardial Infarction. M.J. Platt, J.S. Huber, K.R. Brunt, J.A. Simpson. University of Guelph, Canada and Dalhousie Medicine, Canada. (977.1) Autonomic Nervous Tone During Histopathological Diagnosis of Oral Squamous Cell Carcinoma in Virtual Images. E.A. Mondragon. Universidad Militar “Nueva Granada”, Colombia and Universidad de la Sabana, Colombia. (983.4) Quantitative Image Analysis of Traumatic Brain Injury Induced Aspiration Pneumonia Treatment. C.C. Howell, G.E. Sandusky. Indiana University-Purdue University Indianapolis. (983.1) The Role of IQGAP1 in Transendothelial Migration: From in Vitro Identification to in Vivo Validation. D.P. Sullivan, P.J. Dalal, W.A. Muller. Northwestern University. (978.16) Surface Area May Be a More Useful Risk Factor for Cerebral Aneurysm Rupture Than Maximum Diameter. S. Fukuda, Y. Shimogona. Kyoto Medical Center, Japan and Tohoku University, Japan. (659.17) Aberrant Histone Turnover in Alzheimer’s Disease. J.A. Dowell, M.A. Gitcho, J.M. Denu. Wisconsin Institutes for Discovery, Delaware State University and University of Wisconsin. (659.10) An Integrated Study of Gene Expression Profile Uncovers Similarity Between Embryogenesis, Bone Development, Wound Healing, and Prostate Cancer. T.S. Rayburn, A. Mukherjee, W.A. Byrd, J. Jones. Troy University. (980.2) Identification of Key Transcription Factor Target Interactions That Regulate Prostate Cancer Metastasis. N. Sharma, K.L. Pellegrini, F.O. Giuste, V. Ouellet, D. Trudel, A. Mes-Masson, F. Saad, A.O. Osunkoya, J. Petros, C.S. Moreno. Emory University and University of Montreal, Canada. (980.3) Inhibition of HDAC, Especially HDAC3, Prevents Diabetic Cardiomyopathy in OVE26 Mice via Epigenetic Inhibition of ERK1/2-DUSP5 Pathway. Z. Xu, L. Cai. The First Hospital of Jilin University, People’s Republic of China, Kosair Children Hospital Research Institute and University of Louisville. (977.4)
P28
Epigenetic Regulation of Stab2 Expression in DBA Mice in Determining Atherosclerosis Susceptibility. S. Dong, Y. Kayashima, N. Maeda. UNC-Chapel Hill. (979.4) P29 The Nrf2 Transcription Factor Promotes Efferocytosis by Activating Phosphatidyl Serine Receptor Tim-4 Signaling During Oxidant-Induced Lung Injury Repair. N.M. Reddy, C.R. Tamatam, S.P. Reddy. University of Illinois at Chicago. (470.3) P30 Function of TGF-β Regulated NcRNAas in Cardiac Hypertrophy. X. Yang. Beijing Institute of Biotechnology, People’s Republic of China. (470.5) P31 Withdrawn. (979.1) P32 lncRNAH19/ZEB1/EpCAM Regulatory Axis in Cholestatic Liver Fibrosis. Y. Song, C. Liu, L. Wang. University of Connecticut. (328.6) P33 Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in HepatocyteDriven Liver Regeneration. J.O. Russell, S. Ko, D. Shin, S.P. Monga. University of Pittsburgh. (531.7) P34 Epigenetic Re-Programming of Breast Cancer by Pharmacological Targeting of C-Terminal Binding Protein. J.S. Byun, K.L. Gardner. NIH. (468.2) P35 miR-16 Mediated MYB Gene Silencing Induces Fetal Hemoglobin Expression. C.R. Pounds, M. Takezaki, B. Li, C. Ward, N. Lopez, B.S. Pace. Medical College of Georgia at Augusta University. (979.6) P36 Expression of Matricellular Protein CCN1 in the Tumor Stroma Is Required for Melanoma Metastasis. A. Leask, L. Postovit, K. Quensel, J. Hutchenreuther. Western University, Canada and University of Alberta, Canada. (808.3) P37 Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis. H. Qazi, Z-D. Shi, J.W. Song, L.M. Cancel, L.L. Munn, J.M. Tarbell. The City College of The City University of New York, Sloan-Kettering, The Ohio State University and Massachusetts General Hospital. (808.6) P38 Assessing the Effects of TIMP2 Knockout on Lung Cancer Cell Lines Cultured in 3D. D. Peeney. NCI. (808.4) P39 Solute Carrier Family 2 Member 4 Regulates TRIM24DDX58 Axis to Promote Head and Neck Cancer Metastasis. Y. Chang, M. Hsiao. Academia Sinica, Taiwan. (808.5) P40 Withdrawn. (976.2)
TUESDAY PATHOLOGY P41
Localization of Scleraxis in Dermal and Keloid Fibroblasts. C. Johnson, A. Nillas, T.A. Reaves. Medical University of South Carolina. (182.1) P42 Adducin Regulates Migration and Invasion of Normal Lung Epithelial Cells and Lung Cancer Cells. S. Lechuga, P.H. Amin, A.I. Ivanov. Virginia Commonwealth University. (465.3) P43 The Role of Scleraxis in Neutrophil Activation. O. Awotunde, A. Nillas, S. Hammad, T.A. Reaves. University of Maryland Baltimore County, University of SC School of Medicine and Medical University of SC. (182.2) P44 Thymosin Beta 4 Influences Hedgehog Signaling by Interacting with Smo-Gli2 in Hepatic Stellate Cells. J. Kim, Y. Jung. Pusan National University, Republic of Korea. (804.13) P45 The Assessment of Clinically Relevant Extracellular Matrix Markers in a Bleomycin-Induced Mouse Model of Lung Fibrosis. A. Young, P. Nath, D. Leeming, M. Karsdal, S. Brockbank, D. Rider, S. Cruwys. Discovery, Charles River, United Kingdom, Nordic Biosciences, Denmark and Grunenthal, Germany. (656.18) P46 A Role of IL-21 in Pulmonary Fibroblast Activation. R. Sathiaseelan, C. Huang, L.K. Senavirathna, L. Liu. Oklahoma State University. (656.15) P47 Phospholipase D Regulates GSK3β mediated Epithelial to Mesenchymal Transition and Akt Mediated Cell Death Leading to Pulmonary Fibrosis. V. Suryadevara, T.J. Royston, V. Natarajan. University of Illinois. (656.2) P48 Multipotent Stromal Cell and Fibroblast CoTransplantation Alter Wound Microenvironment to Normalize Aged-Deficient Wound Healing. B. Lantonio, M. Rosano, B. Brown, A. Wells, C.C. Yates. University of Pittsburgh. (333.3) P49 Cytoprotective Chaperone Proteins Are Novel AntiInflammatory Targets in Sickle Cell Disease. C. Anea, S. Kumar, I. Lee, J. Brittain. Augusta University. (981.3) P50 ATF3 Protects LPS-Induced Acute Pancreatic Inflammation via Modulating NFκB-Mediated iNOS Production in Mice. Y. Chen, Y. Tseng, C. Liu, H. Lin, C. Cheng, P. Lai. Tzu Chi University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Taipei Medical University, Taiwan. (657.2) P51 Pro-Inflammatory and Anti-Inflammatory Cytokine Expression in Tnf -/- and WT Mice with Chronic Colitis. T.M. Smith, A. Kozik, C.H. Nakatsu, Y.L. Jones-Hall. Purdue University. (657.4) P52 Paradoxical Effects of PGC-1 Isoforms on Retinal Pigment Epithelium: Implication for Neovascular Retinal Diseases. M. Saint-Geniez, Q. Charles, M. Rosales, A. Khadka, J. Iacovelli. Harvard Medical School, Schepens Eye Research InstituteMassachusetts Eye and Ear Infirmary and Boston University. (976.11)
P53
Effects of High Fat Diet on 4-NQO-Induced Changes in a Variety of Tissues in a Mouse Model of Oral Cancer. J. Goral, A. Meyer, L. Pitstick, M. Pytynia, R. Schmelter, F. Syed, A. Barakat, D. Oswald, A. Gladding, J. Pescatore, J.M. Green, M.J. Ciancio, B. Jham. Midwestern University. (806.3) P54 The Unfolded Protein Response Regulates Pancreatic Neuroendocrine Tumor Growth. S.A. Oakes, J.Y. Qi, P.C. Moore, R.A. Warren, M. Thamsen, R. Ghosh, M.J. Gliedt, D.J. Maly, B.J. Backes, F.R. Papa. University of California San Francisco and University of Washington. (178.4) P55 How the Cytosol-To-Membrane Translocation Kinetics and Signaling of PKCγ Are Dysregulated in the Neurodegenerative Spinocerebellar Ataxia Type14 (SCA14). N. Aslam, F. Alvi. BioSystOmics and COMSAT Institute of Information Technology, Pakistan. (183.4) P56 Model Systems to Study the Pathogenesis of Zika VirusMediated Eye Disease. L.E. Martinez, D. Contreras, M.K. Jones, V. Gangalapudi, J. Tang, S. Wang, V. Arumugaswami. Cedars-Sinai Medical Center. (658.12) P57 Automated Fluorescent Miscroscopic Image Analysis of PTBP1 Expression in Glioma. B. Goksel, E. Goceri, B. Elder, V. Puduvalli, M. Gurcan, J.J. Otero. The Ohio State University. (980.1) P58 PSEN1 as an Adjunct for Diagnosis of Human Myocarditis. P.J. Hanson, E.L. Jang, H. Rai, A.Y. Chang, A.Y. Mo, B.M. McManus, M.A. Seidman. University of British Columbia, Canada and Providence Health Care, Canada. (977.2) P59 Fibrinogen Alpha Is the Precursor Protein of Cardiac Valve Amyloidosis. K. Miura, H. Katoh, T. Tsuchida. Hamamatsu University School of Medi, Japan and Kosai Hospital, Japan. (977.7) P60 Use of Anchored Multiplex PCR Enrichment for Detection of Gene Fusions in Solid Tumors by Next Generation Sequencing. D.C. Green, S.J. Deharvengt, F.B. de Abreu, H.B. Steinmetz, J.D. Peterson, G.J. Tsongalis. Dartmouth Hitchcock Medical Center, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center and Geisel School of Medicine. (807.20) P61 Molecular Diagnostic Techniques Used to Confirm an Unusual Case of BAPoma. A. Atkinson, K. Linos, S. Yan, G. Tsongalis, J. Lefferts. Dartmouth-Hitchcock Medical Center. (807.17) P62 Integrin β6: Lost in Translation from Mouse to Human as a Target for Hepatic Fibrosis. C. Saravanan, Y. Song, P. Wu, W. Hu, F. Bian, A. Heidt, K. Mansfield. Novartis Institutes for Biomedical Research Institutes (NIBR), NIBR, People’s Republic of China, and The Genomics Institute of the Novartis Research Foundation. (804.10)
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Kinesiological Benefits of Botulinum Toxin Type A Combined with Exercise on the Functional Recovery After Spinal Cord Injury. Y. Jin, S. Park, Y. Hong. Graduate School of Inje University, Republic of Korea, Inje University, Republic of Korea. (981.2) P64 Dna Methylation, Hydroxymethylation and Formylation in Human Frontal Cortex of Autistic and Schizophrenic Subjects. R. Deth, Y. Zhang, H. Abdolmaleky, M. Trivedi. Nova Southeastern University, Northeastern University and Boston University. (468.3) P65 Cyclin A2 Loss Impairs Hippocampal Development. M. Goksel, P. Gygli, J. Chang, B. Goksel, H.N. Gokozan, R. Nelson, C. Czeisler, J.J. Otero. The Ohio State University. (659.2) P66 Visualization of Neuronal Connectivity in NPARM PHOX2b Mutants with a Modified PACT Protocol. S.R. Fair. The Ohio State University. (659.3) P67 A Novel Neuroprotective Effect of Osteoactivin in Parkinson’s Disease. K.M. Budge, G. Alam, M. Edler, J. Richardson, F. Safadi. Kent State University and Northeast Ohio Medical University. (183.1) P68 Regulator of G-Protein Signaling 6 (RGS6) Expression in Human Substantia Nigra Pars Compacta (SNc) and Loss in Parkinson’s Disease (PD). Z. Luo, K.E. Ahlers, J. Yang, B. Chakravarti, H.E. Stevens, N.S. Narayanan, R.A. Fisher. The University of Iowa. (659.23) P69 Investigating the Underlying Mechanisms of Chemosensory Dysfunctions in Alzheimer’s Disease Using Caenorhabditis elegans with Mutations in Presenilin 1. M. Parvand, T. Bozorgmehr, C. Rankin. University of British Columbia, Canada. (659.9) P70 Caffeine May Affect Apoptosis and Autophagy Activity to Promote Dopaminergic Cells Survival Under the Rotenone Induced Parkinson Disease Model. C. Luo, Y. Huang, B. Huang, T. Lu, Y. Fu. Department of Biomedical Science and Environmental Biology, Kaohsiung Medial University, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Taiwan, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Department of Biomedical Science and Environmental Biology, Center for Infectious Disease and Cancer Research and Kaohsiung Medical University, Taiwan. (659.8) P71 Assessing Gliogenesis in a Murine Multifactorial Brain Injury Model System. M.S. Domowicz, N.L. Wadlington, J.G. Henry, K. Diaz, M.J. Munoz, N.B. Schwartz. University of Chicago. (183.3) P72 High Fat Diet Increases Cognitive Decline and Neuroinflammation in a Model of Orexin Loss. C.M. Duffy, J.P. Nixon, T.A. Butterick. Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota’s Discovery, Research, and Innovation Economy, Brain Conditions and Minnesota Obesity Center. (659.12)
150
P73
APOE Genotype Influences Glial Activity in MS. Z. Langston, M. Lahey, A. Affaneh, E. Cudaback. DePaul University. (659.15) P74 The Effect on the Content of Nogo-A in the Damage Area of the Rats Brain with Fasudil After Traumatic Brain Injury. H. Duan, C. Hao, C. Liu, S. Li, L. Gao, X. Zheng. The First Clinical College of Shanxi Medical University, People’s Republic of China, The First Hospital of Shanxi Medical University, People’s Republic of China. (183.5) P75 Modeling the Ischemic Neurovascular Unit in a Dish Using Patient-Specific Induced Pluripotent Stem Cells. S. Page. TTUHSC. (659.20) P76 Animating External Magnetic Guidance of Intrathecally Delivered Gold-Coated Nanoparticles to Treat Intramedullary Spinal Tumors. A. Orland, K. Brennan, L. Lebowicz, C. Wellman, A. Mehta. University of Illinois at Chicago. (659.21) P77 Development of a Silver Methenamine Masson Trichrome (SMMT) Stain for Use in Sheep Kidneys. M. Smith, K. Wyatt, J. Weng, A.S. Davis. College of Veterinary Medicine and Kansas State University. (983.2) P78 Spectral Domain Optical Coherence Tomography Correlates Retinal Thinning to Retinal Vascular Development in an in Vivo Mouse Model of Retinopathy of Prematurity. O.J. Mezu-Ndubuisi, L.K. Taylor, J.A. Schoephoerster. University of Wisconsin. (978.2) P79 Cathepsin K Cleavage of SDF-1α Inhibits Its Chemotactic Activity Toward Glioblastoma StemLike Cells in Their Niches. V. Hira, U. Verbovšek, B. Breznik, H. Kakar, J. Wormer, B. Van der Swaan, S. Mehta, T. Lah, C. Van Noorden. Academic Medical Center, Netherlands, Barrow Neurological Institute and National Institute of Biology, Slovenia. (808.2) P80 Enteroaggregative Escherichia coli Delocalized B-Catenin Adherens Junction in Ileum and Colon Enterocytes in an Infection Mouse Model with a Disturbed Microbiota. N.E. Moran García, C. LopezSaucedo, S. Galindo-Gómez, V. Tsutsumi, A. Felipe-Lopez, M. Schnoor, J.P. Nataro, T. EstradaGarcia. CINVESTAV-IPN, Mexico and University of Virginia School of Medicine. (184.3) P81 Internalization and Trafficking of PD-L1 in MDAMB231 Breast Cancer Cells. A. Rudkouskaya, M. Barroso. Albany Medical College. (809.7) P82 Sex Dependent Role of Activating Transcription Factor 3 (ATF3) Expression in Modulating the Asthmatic Phenotype in an Acute Mouse Model of Airway Neutrophilia. A. Spinelli, N. Fuentes Ortiz, M. Nicoleau, U. Sinha, C.R. Caruso, S. DiAngelo, Z. Chroneos, P. Silveyra Penn State College of Medicine and MS Hershey Medical Center. (656.9) P83 STAT3 and MEK Mediate IL6-Induced Increase in Endothelial Permeability. H. Alsaffar, N. Martino, A. Adam. Albany Medical College. (55.6)
TUESDAY PATHOLOGY P84
Atrogin-1 Transgenic (At1 Tg+) Mice Have AgeDependent Cardiac Dysfunction with Atrogin-1 Mediated Glucocorticoid Receptor (GR) Expression Down Regulation. R. Mota, T. Parry, M. Willis. UNC at Chapel Hill. (59.5) P85 Effect of Mitoquinone Treatment on Cardiac Function and Pathophysiology in Pressure Overload-Induced Heart Failure. K. Goh, A.R. Wende, R.N. Soorappan, G. Halade, V. Darley-Usmar, M. Jinno, S.D. Prabhu, L. Zhou. University of Alabama at Birmingham. (59.7) P86 Neuroanatomical Analysis of a Conditional Knockin Mutant PHOX2B Mouse Model. J. Liu, C. Czeisler, S. Fair, B. Goksel, M. Goksel, J. Otero. The Ohio State University. (183.2) P87 Pyruvate Dehydrogenase Kinase 4 Deficiency Induces Hepatic Apoptosis by Activating NF-κB/ TNFα Signaling. J. Wu, J. Choiniere, M. Lin, L. Wang. University of Connecticut, Wenzhou Medical University, People’s Republic of China, Veterans Affairs Connecticut Healthcare System and Yale University. (470.9) P88 Gut Microbial Metabolites Establish a Gradient of Extracellular Protons, Which Mediate MicrobiotaStimulated Intestinal Repair via Proton-Sensing G-Protein Coupled-Receptors. M. Alam, H. Wu, J. Matthews, B. Saeedi, R. Jones, A.S. Neish. Emory University School of Medicine. (469.3) P89 CD47 Regulates CDd11b-Dependent Neutrophil Transepithelial Migration During Intestinal Inflammation. V. Azcutia, A. Luissint, S. Flemming, M. Quiros, A. Nusrat, F.W. Luscinskas, C.A. Parkos. University of Michigan and Brigham and Women’s Hospital and Harvard Medical School. (469.6) P90 Entamoeba histolytica Stimulates the Release of the Alarmin Molecule HMGB1 by a PI3 Kinase Dependent Mechanism. S. Begum, F. Moreau, J. St-Pierre, K. Chadee. University of Calgary, Canada. (55.2) P91 Hypoxia Inducible Factor (HIF)-1 Accelerates Epithelial Wound Healing Through Integrin Regulation. B.J. Goggins, K. Minahan, N. Outteridge, D. Knight, J. Horvat, S. Keely. University of Newcastle, Australia and Hunter Medical Research Institute, Australia. (465.11) P92 I tryptophan Metabolite Activation of the Aryl Hydrocarbon Receptor in Intestinal Epithelia Promotes Mucosal Healing. J.M. Lanis, E. Alexeev, S. Colgan. University of Colorado- Anschutz Medical Campus. (465.9) P93 Giardia duodenalis alters Intestinal Mucin Transcription and Disrupts the Mucus Layer in a Cysteine ProteaseDependent Manner. C.B. Amat, J. Motta, K. Chadee, A.G. Buret. University of Calgary, Canada. (184.2) P94 Glial Cell-Line Derived Neurotrophic Factor Attenuates Inflammation-Induced Breakdown of Intestinal Epithelial Barrier Function by Stabilization of Dsg2Dependent Intercellular Adhesion. M. Meir, N. Burkard, S. Flemming, C. Germer, J. Waschke, N. Schlegel. University Hospital Würzburg, Germany, University of Michigan and Ludwig-MaximiliansUniversität München, Germany. (465.5)
P95
Intestinal Mucosa Pro-Repair Properties of Macrophage Derived IL-10 Are Mediated by CREB Triggered Epithelial WISP-1 Signaling. M. Quiros, H. Nishio, P.A. Neumann, G. Leoni, V. Garcia-Hernandez, D. Siuda, M. Feng, G. Bernal, R. Hilgarth, H. Williams, J.C. Brazil, P.H. Dedhia, J. Spence, C.A. Parkos, T.L. Denning, A. Nusrat. University of Michigan, Universität München, Germany, Institute for Cardiovascular Prevention, Germany, Emory University and Georgia State University. (465.2) P96 Role of PMNs in Inhibition of DNA Repair and Induction of Genomic Instability. V. Butin-Israeli, L. Mehl, L. Lorraine Mascarenhas, R. Sumagin. Northwestern University. (178.5) P97 A Circadian Zip Code Determines Rhythmic Leukocyte Trafficking to Tissues. W. He, K. Kraus, D. Druzd, A. de Juan, L. Ince, C. Chen, C. Scheiermann. WalterBrendel-Zentrum für Experimentelle Medizin LudwigMaximilians-Universität München, Germany. (55.4) P98 Force-Induced α4 Integrin-Dependent Monocyte Adhesion Strengthening and F-Actin Remodeling Requires Actomyosin Contractility and Talin-1. H.M. Ibrahim, S.J. Hyduk, M.I. Cybulsky. Toronto General Hospital Research Institute, University Health Network, Canada and University of Toronto, Canada. (55.8) P99 Neutrophils Induce Pro-Angiogenic T Cells with a Regulatory Phenotype in Pregnancy. S. Nadkarni, J. Smith, A. Sferruzzi-Perri, M. Kishore, C. Mauro, D. Williams, F. Marelli-Berg, M. Perretti. Queen Mary, University of London, United Kingdom, Cambridge University, United Kingdom and University College London, United Kingdom. (469.10) P100 The CXCR3-LFA1-ICAM1 Axis Regulates T Cell Cardiotropism and Maladaptive Cardiac Remodeling in Heart Failure. A. Salvador, T. Nevers, F. Velazquez, M. Aronovitz, P. Alcaide. Tufts University, Universidad de Granada, Spain and Tufts Medical Center. (327.3) P101 Histamine Causes Endothelial Barrier Disruption via Ca2+-Mediated RhoA Activation and Enhanced Force Generation at Intercellular Junctions. L. Rotkopf, D. Kugelmann, E. Walter, M. Radeva, J. Waschke. Ludwig-Maximilians-Universität München, Germany. (978.1) P102 CD43 Syalomucin Contributes to Cardiac Inflammation and Fibrosis in Non-Ischemic Heart Failure. F. Velázquez, A. Salvador, T. Nevers, N. Ngwenyama, M. Aronovitz, R. Blanton, P. Alcaide. Tufts University and Tufts Medical Center. (59.2) P103 PAD4 Deficiency Limits Kidney Dysregulation in a Murine Model of Shock/Sepsis. B. Biron Girard, Y. Chen, C. Chung, J.B. Reichner, A. Ayala. Brown University/Rhode Island Hospital and Rhode Island Hospital. (657.16)
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Small Peptide Antagonists Derived Based on in Silico Analysis Block CXCL10-CXCR3 Signaling and Function on Cardiac Fibroblasts and Cardiomyocytes. L. Espinoza Ornelas, B.J. Lantonio, J. Jaynes, R. Bodnar, M.S. Willis, C.C. Yates. University of Pittsburgh, Tuskegee University and University of North Carolina at Chapel Hill. (984.1) P105 Identifying Key Domains in Endothelial IQGAP1 Critical for Leukocyte Transmigration. P. Dalal, D. Sullivan, W. Muller. Northwestern University. (657.10) P106 Reliable CD4 and CD8TCell Marker Immunohistochemistry on Formalin-Fixed and Histochoice-Fixed Paraffin Embedded Mouse Spleen. K.N. Bradshaw, J. WengRace, J.M. Ward, J.E. Rehg, J.A. Kovacs, A.S. Davis Kansas State University, Global VetPathology, St. Jude Children’s Research Hospital and National Institutes of Health Clinical Center. (979.5) P107 Detection of Phenotypic Differences in Alveolar Macrophages Using Ionized Calcium-Binding Adapter Molecule 1 Marker. D.K. Meyerholz, C.M. Hogan, R.M. Glanz, J.A. Goeken, M.R. Leidinger, G.K. Ofori-Amanfo, L. McQuillen, K.M. Donovan, S.C. Harwani, H.A. Flaherty. University of Iowa Carver College of Medicine, University of Southern California and Iowa State University. (656.20) P108 Sex, Age, and TNF Influence the Gut Microbiota in a Mouse Model of TNBS Colitis. A.J. Kozik. Purdue University. (657.12) P109 Lack of NF-κB-Inducing Kinase (NIK) Results in Eosinophilic Esophagitis (EoE) and Gastric Hyperplasia in Mice: Implications for Noncanonical NF-κB Signaling in Human EoE. K. Eden, D.K. McDaniel, B. Heid, I.C. Allen. Virginia Maryland College of Veterinary Medicine. (469.12) P110 Reverse Transcriptase Real Time PCR Detection of Rift Valley Fever Virus RNA in Formalin-Fixed, Paraffin-Embedded Tissues. D. Upreti, W.C. Wilson, J.A. Richt, A.S. Davis, J.D. Trujillo. Kansas State University, USDA and ARS. (658.5) P111 Evaluation of Fluorescence Microsphere Immunoassay for Antibody Detection to Rift Valley Fever Nucleocapsid Protein and Glycoproteins. I. Ragan, B. Faburay, D.S. McVey, J.A. Richt, A.S. Davis, R.R. Rowland, W.C. Wilson. Kansas State University and USDA ARS. (658.4)
152
P112 Immuno-Modulating and Anti-Viral Properties of Tulathromycin in Porcine Reproductive and Respiratory Syndrome. D.J. Desmonts de Lamache, R.D. Moges, R. Yates, N. McKenna, D.W. Morck, A.G. Buret University of Calgary, Canada. (984.6) P113 Molecular Analysis of the Blood-Tumor Barrier in Brain Metastasis from Breast Cancer. L. Lyle, R. Duchnowska, P. Lockman, C. Adkins, A. Shareef, E. Sechrest, E. Hua, D. Liewehr, S. Steinberg, W. Kloc, N. Nayyar, P. Brastianos, S. Patricia, B. Gril. National Cancer Institue, Purdue University, Military Institute of Medicine, Poland, West Virginia University, Copernicus Hospital Gdansk, Poland and Harvard Medical School. (808.1) P114 RGDSK Peptide Functionalized Helical Rosette Nanotubes (RGDSK-HRNs) Block Integrin αvβ3 and inhibit E. coli Adherence to Intestinal Porcine Epithelial 1 Cell Line (IPEC1) in Vitro. N. Le, C. Quach, G. Aulakh, V. Gerdts, H. Fenniri, B. Singh. Western College of Veterinary Medicine, University of Saskatchewan, Canada, Vaccine and Infectious Disease Organization—International Vaccine Centre (VIDO-InterVac), Canada, Northeastern University, Faculty of Veterinary Medicine and University of Calgary, Canada. (658.10) P115 Developing an in Vivo Model of Reinke’s Edema. A. Durkes, P. Sivasankar. Purdue University. (656.22) P116 Investigative Analysis of the Waste Impact in the Environmental by Necropsies in Rescued Sea Turtles (Chelonia mydas) in Ubatuba, São Paulo State, Brazil. J. Duarte, T.C. Hipolito, A.C. Tasaka, V.C. Hyodo, E. Mergulhao. UNIP, Brazil. (982.8) P117 SREBP-1c Increases the Hepatic Inflammatory Response in Dairy Cows with Fatty Liver Through ROS-Mediated NF-κB Pathway. X. Li, G. Liu. Jilin University, People’s Republic of China. (804.4) P118 Characterization of Immunodeficient Mouse Models. J. McClellan, R. Macasocal, T. Hare, M. Horn. Envigo. (807.14) P119 Investigating the Potential Role of North American Animals as Hosts for Zika Virus. I. Ragan, E. Blizzard, R. Bowen. Kansas State University and Colorado State University. (658.3)
TUESDAY PHARMACOLOGY
Pharmacology 473. JULIUS AXELROD AWARD IN PHARMACOLOGY LECTURE
475. SCIENCE AND GOVERNMENT: HOW TO MAKE A DIFFERENCE THROUGH ADVOCACY
Award Lecture
Symposium
Tue. 8:30 am—McCormick Place Convention Center, W470B
(Sponsored by: ASPET 2016 Washington Fellows) Tue. 9:30 am—McCormick Place Convention Center, W475
Cancer Biology
Chaired: A.C. Marshall and N.K. Patil
Cardiovascular Biology The Julius Axelrod Award is presented annually for significant contributions to understanding the biochemical mechanisms underlying the pharmacological actions of drugs and for contributions to mentoring other pharmacologists. The Award was established in 1991 to honor the memory of the eminent American pharmacologist who shaped the fields of neuroscience, drug metabolism, and biochemistry and who served as a mentor for numerous eminent pharmacologists around the world. This lecture runs from 8:30 am–9:20 am. 8:30 Introduction. 8:35 Lessons from Endogenously Expressed GPCRs: Nature Knows Best!. Paul Insel. Univ. of California, San Diego.
474. JULIUS AXELROD SYMPOSIUM: EVOLVING INSIGHTS REGARDING GPCRS: COMPARTMENTATION, SIGNALING AND CLINICAL UTILITY Symposium (Sponsored by: John V. Croker Fund) Tue. 9:30 am—McCormick Place Convention Center, W470B
Professional Development Education Science Policy This session runs from 9:30 am–12:00 pm. 9:30
Looking for a Few Good Fellows: The Critical Role of Early Career Scientists in Advocacy. Kenneth Thummel, Univ. of Washington, and Susanna Aguirre, ASPET. 9:45 From PhD to Policy: Advancing Your Career and Advocacy. Remy Brim. 10:15 Getting Involved Early: How Young Scientists Can Make a Difference. Debra Cooper. California Senate Office of Research. 10:45 Bridging the Gap for Drug Development. Dennis Marshall. Ferring Pharmaceuticals, Inc. 11:15 Finding Your Voice: How to be an Advocate for Science. Yvette Seger. FASEB. 11:45 Panel Discussion.
476. PERINATAL THERAPEUTICS AND THE PROGRAMMING OF ADULT CARDIOMETABOLIC DISEASE Symposium
Chaired: P.A. Insel
(Sponsored by: ASPET Division for Cardiovascular Pharmacology)
Cancer Biology Inflammation/Immunity
Tue. 9:30 am—McCormick Place Convention Center, W470A
Metabolism and Metabolic Disease
Chaired: S.L. Bourque and S. Goulopoulou
9:30 Introduction. Paul Insel. Univ. of California, San Diego. 9:35 Structure, Activation and Inhibition of Chemokine Receptors. Tracy Handel. Univ. of California, San Diego. 10:05 The Membrane-intracellular Organelle Interface: A Compartment for GPCR Regulation of Cellular Metabolism and Function. Hemal Patel. Univ. of California, San Diego. 10:35 cAMP Signaling Compartments: Adenylyl Cyclases as the Anchors. Rennolds Ostrom. Chapman University. 11:05 Beta-3 Adrenoceptor Agonists: A Case Study of Pharmacology in First-in-class GPCR Drug Discovery and Development. Martin Michel. Johannes Gutenberg University. 11:35 Panel Discussion.
Cardiovascular Pharmacology Drug Discovery and Development Translational and Clinical Pharmacology This session runs from 9:30 am–12:00 pm. 9:30
Epigenetics and the Developmental Origins of Obesity, Type 2 Diabetes, and Cardiovascular Disease: Known, Unknowns and Possibilities. Susan Ozanne. Univ. of Cambridge. 10:00 Gestational Diabetes and Fetal Programming of Metabolic Function: Mechanisms and Interventions. Vernon Dolinsky. Univ. of Manitoba.
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PHARMACOLOGY TUESDAY 10:30 Early Postnatal Interventions for the Sex-specific Programming of Cardiovascular Dysfunction by Prenatal Hypoxia. Sandra Davidge. University of Alberta. 11:00 The RAS as a Therapeutic Target for the Fetal Programming of Cardiovascular Disease. Karen Moritz. The Univ. of Queensland. 11:30 Gestational Exposure to Engineered Nanomaterials Effects Microvascular Health of Young Progeny. P.A. Stapleton. Rutgers University. (997.4) 11:45 Fetal Betamethasone Exposure Markedly Attenuates the Protein Expression of Angiotensin Converting Enzyme 2 but Not Dipeptidyl Peptidase 3 Within the Brain Dorsomedial Medulla of Adult Female Sheep. A.S. Hendricks, H.A. Shaltout, M.C. Chappell, D.I. Diz. Wake Forest School of Medicine. (997.6)
477. QUANTITATIVE SYSTEMS PHARMACOLOGY: APPLICATION TO CANCER DRUG DEVELOPMENT AND PERSONALIZED/ PRECISION MEDICINE Symposium (Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Tue. 9:30 am—McCormick Place Convention Center, W471A Chaired: J.L.S. Au and J.S.H. Lee Translational and Clinical Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. Application of QSP in Therapy Development: Intravesical Bladder Cancer Therapy as an Example. Jessie Au. Optimum Therapeutics LLC, Inst. of Quantitative Systems Pharmacology, Univ. of Oklahoma, Taipei Med Univ., The Ohio State Univ. 9:45 Current and Future Technologies NCI Supports in Oncology Drug Discovery and Development. Jerry Lee. National Cancer Institute. 10:05 Using Novel Quantitative Approach to Under Association Between the Biological Targets and Adverse Reactions for Tyrosine Kinase Inhibitors. Liang Zhao. US Food and Drug Administration. 10:25 Q&A. 10:40 Pharmacogenomics: One Piece of the Puzzle in Personalized and Precision Medicine. Stephen Eck. Astella Pharma. 11:00 Translational Bioinformatics Research in Drug Interaction and Its Application in the Precision Medicine. Lang Li. Indiana Univ. 11:20 A Quantitative Systems Pharmacology Approach to Antiangiogenic Therapy. Sukung Woo. Univ. of Oklahoma Health Sciences Center. 11:40 Q&A. 11:55 Wrap Up.
478. EMERGING TECHNOLOGIES FOR SELECTIVELY MODULATING THE TUMOR IMMUNE CONTEXTURE Symposium (Sponsored by: ASPET Division for Drug Discovery and Development) Tue. 9:30 am—McCormick Place Convention Center, W474A Chaired: S. Sengupta and A.A. Kulkarni Drug Discovery and Development Cancer Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. 9:30
Engineering Enhanced Cancer Vaccines. Darrell Irvine. Massachusetts Inst. Of Technology. 10:00 Supramolecular Therapeutics that Selectively Modulate the Tumor Immune Contexture. Shiladitya Sengupta. Harvard Medical School Medicine. 10:30 Targeting the Immune Cells for Anticancer Efficacy. Puja Sapra. Pfizer, Inc. 11:00 Imaging an Immunotherapy Response in Real-time. Ashish Kulkarni. Brigham and Women’s Hosp, Harvard Medical Sch. 11:30 Peptide-Based Targeted Delivery for Immune Modulation. Hongbo Pang. Burnham Institute. 11:58 Conclusion.
479. MUSHROOMING POTENTIAL OF PSYCHEDELICS AS THERAPEUTICS
9:30
154
Symposium (Sponsored by: ASPET Division for Behavioral Pharmacology) Tue. 9:30 am—McCormick Place Convention Center, W474B Chaired: W.E. Fantegrossi and R. Griffiths Behavioral Pharmacology Science Policy Neurobiology This session runs from 9:30 am–12:00 pm. 9:30
Animal Models of Hallucinogens and Serotonin 5-HT2A Receptor Neuropharmacology. Javier GonzalezMaeso. Virginia Commonwealth Univ. 10:00 Therapeutic Potential of 5-HT2A Agonists for Psychiatric Disorders: Are Psychedelic Effects Necessary? Clinton Canal. Northeastern Univ. 10:30 Human Psychopharmacology of Hallucinogens. Theresa Carbonaro. Johns Hopkins University Sch. Of Med. 11:00 Hallucinogens as Novel Psychotherapeutics. Roland Griffiths. Johns Hopkins Univ. Sch. of Med. 11:30 Panel Discussion. William Fantegrossi. Univ. of Arkansas for Medical Sciences.
TUESDAY PHARMACOLOGY
480. DAVID LEHR RESEARCH AWARD LECTURE Award Lecture
482. DIVISION FOR NEUROPHARMACOLOGY POSTDOCTORAL SCIENTIST AWARD FINALISTS
Tue. 2:00 pm—McCormick Place Convention Center, W470B
Division Oral Session (Sponsored by: ASPET Division for Neuropharmacology)
The David Lehr Research Award is intended to extend funding for preclinical or clinical research directed towards improving human health. The inaugural recipient of the award in 2015 will present his research.
Tue. 3:00 pm—McCormick Place Convention Center, W470A Chaired: M.W. Wood and B. Greenwood-Van Meerveld
This lecture runs from 2:00 pm–2:50 pm. 2:00 Introduction. David Sibley. ASPET. 2:05 Adenosine-Regulated Glutamate Signaling in NeuronGlia Interaction and Alcoholism. Doo-Sup Choi. Mayo Clinic College of Medicine.
Neuropharmacology Neurobiology This session runs from 3:00 pm–5:30 pm. 3:00
481. SURMOUNTING THE INSURMOUNTABLE: OBSTACLES IN DRUG DISCOVERY AND DEVELOPMENT—REAL WORLD CASE STUDIES Symposium (Cosponsored by: ASPET BIG IDEAS Initiative and ASPET Division for Drug Discovery and Development)
3:15
Tue. 3:00 pm—McCormick Place Convention Center, W475 Chaired: K. He and P.F. Hollenberg
3:30
Drug Discovery and Development Drug Metabolism
3:45
Inflammation/Immunity A product of the ASPET BIG IDEAS initiative, this workshop is a forum for pharmacological experts to present “real world” stories recounting when, in their own experience, insurmountable problems arose and explaining how critical thinking and problemsolving skills were used for the drug development process to continue.
4:00
This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Sustiva: A Rescue from Death Due to Nonclinical Toxicity. Gerald Miwa. Univ. of North Carolina, Eshelman Sch. of Pharmacy. 3:40 Challenges in the Discovery and Development of Vorapaxar, A Novel Antiplatelet Drug. Madhu Chintala. Johnson & Johnson. 4:15 Empagliflozin: Sex, Species, and Tissue-specific Metabolism. Mitchell Taub. Boehringer Ingelheim Pharmaceuticals. 4:50 Apixaban: How Volume of Distribution Became Critical in Optimizing Efficacy and Minimizing Toxicity. Kan He. Biotranex, LLC. 5:25 Conclusion. Paul Hollenberg. Univ. of Michigan.
4:15
4:30
Estrous Cycle-Dependent Alterations in Cocaine Affinity at the Dopamine Transporter Underlie Enhanced Cocaine Reward in Females. E.S. Calipari, B. Juarez, C. Morel, D.M. Walker, M. Cahill, E. Riberio, K. Deisseroth, M. Han, E.J. Neslter. Icahn School of Medicine at Mount Sinai and Stanford University. (989.6) Cortical Circuit Dynamics During Punishment-Resistant Alcohol Drinking. C.A. Siciliano, Y. Leow, C. Vander Weele, E. Kimchi, D. Xu, X. Chen, K.M. Tye. Massachusetts Institute of Technology. (661.6) Altered Kisspeptin Responsiveness in Bmal1 Knockout Females. K.J. Tonsfeldt, E. Schoeller, L. Brusman, P. Mellon. University of California San Diego. (989.7) The Neuroprotective Role of Myeloid Zinc Finger-1 and Specificity Protein 1 During Treatment with Leukemia Inhibitory Factor. S. Davis, L. Collier, J. Fazal, M. Britton, C. Leonardo, C. Ajmo, K. Pennypacker. University of Kentucky and University of South Florida. (815.6) A G Protein-Biased Ligand of the Kappa Opioid Receptor Is Antinociceptive and Antipruritic but Does Not Cause Sedation or Dysphoria. T.F. Brust, J. Morgenweck, S.A. Kim, J.H. Rose, J.L. Locke, C.L. Schmid, L. Zhou, E.L. Stahl, M.D. Cameron, S.M. Scarry, J. Aubé, S.R. Jones, T.J. Martin, L.M. Bohn. The Scripps Research Institute, Wake Forest School of Medicine and University of North Carolina at Chapel Hill. (992.4) Organic Cation Transporter 3 Upregulation in Serotonin Transporter Deficient Mice Potentiates EthanolInduced Serotonin Clearance Impairments. T.L. Gilman, R.E. Horton, N.L. Baganz, S.R. Alvarado, L.C. Daws. University of Texas Health Science Center at San Antonio. (661.4) Pharmacologic Inhibition and Genetic Elimination of p38α MAPK Normalizes Serotonergic System Alterations and Social Behavior Deficits in the SERT Ala56 Mouse Model of Autism Spectrum Disorder. M.J. Robson, M.A. Quinlan, J. VeenstraVanderWeele, D. Watterson, R.D. Blakely. Florida Atlantic University, Vanderbilt University, Columbia University and Northwestern University. (813.10)
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PHARMACOLOGY TUESDAY 4:45
5:00
5:15
Endogenous Melatonin Decreases Place Preference for Methamphetamine Through a Learning and Memory Independent Mechanism in C57BL/6 Mice. S.J. Clough, T. Kasahara, K.M. Veros, R.L. Hudson, M.L. Dubocovich. Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY and RIKEN Brain Science Institute, Japan. (662.11) Blockade of a Novel Neuropeptide Receptor System, BigLEN-GPR171, Reduces Adverse Effects of Prolonged Morphine Administration. E.N. Bobeck, D. Pena, I. Gomes, A. Fakira, L. Devi. Icahn School of Medicine at Mount Sinai and University of São Paulo, Brazil. (985.8) Enhanced Mitochondrial Biogenesis for the Treatment of Spinal Cord Injury. N.E. Scholpa, A. Narang, W. Wang, D. Corum, S. Tomlinson, R.G. Schnellmann. University of Arizona and Medical University of South Carolina. (815.13)
483. DIVISION FOR TOXICOLOGY—IN UTERO AND NEONATAL EXPOSURE TO ENVIRONMENTAL AGENTS Division Symposium (Sponsored by: ASPET Division for Toxicology) Tue. 3:00 pm—McCormick Place Convention Center, W470B Chaired: M. Valentovic Toxicology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Presentation of Division for Toxicology Career Award. Lauren Aleksunes. Rutgers Univ. 3:10 Prenatal Exposure Resulting in PAH-DNA Adducts in Umbilical Cord Blood. Monica Valentovic. Marshall Univ. School of Medicine. 3:30 Human Prenatal Exposure to Essential and Toxic Elements. Jesse Cottrell. Marshall Univ. School of Med./Univ. of Mississippi Med. Ctr. 3:50 Age-Related Changes in the Disposition of Pyrethroid Insecticides. Catherine White. Univ. of Georgia. 4:23 Microvascular Ramifications of Maternal Nanomaterial Inhalation: Uterine and Fetal Perspectives. Tim Nurkiewicz. West Virginia Univ. 4:56 Gestational Nanomaterial Exposures: The Next Generation. Phoebe Stapleton. Rutgers Univ. School of Pharmacy. 5:29 Wrap Up.
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484. DIVISION FOR CANCER PHARMACOLOGY— YOUNG INVESTIGATORS SYMPOSIUM Division Oral Session (Sponsored by: ASPET Division for Cancer Pharmacology) Tue. 3:00 pm—McCormick Place Convention Center, W474A Chaired: S.P. Cole and J.C. Yalowich Cancer Pharmacology Cancer Biology This session runs from 3:00 pm–5:30 pm. 3:00
Lipidomic Profiling Identifies Cytochrome P450 as a Therapeutic Target for Colitis-Associated Colorectal Cancer. W. Wang, J. Yang, M. Song, D. Wan, H. Yang, K. Sanidad, B.D. Hammock, H. Xiao, G. Zhang. University of Massachusetts, University of California at Davis. (823.5) 3:20 The Interaction of GIV with Galpha-I Is a Druggable Protein-Protein Interaction. V. DiGiacomo, A.I. de Opakua, N. Merino, J.B. Blanco-Canosa, F.J. Blanco, M. Garcia-Marcos. Boston University School of Medicine, CIC-BioGune, Spain and Institute for Research in Biomedicine, Spain. (823.6) 3:40 A Constitutive Androstane Receptor (CAR) Inhibitor CINPA1 as a Tool to Understand Receptor Structure and Function. M.T. Cherian, S.C. Chai, M.A. Casal, T. Chen. St Jude Children’s Research Hospital and University of Pittsburgh. (671.14) 4:00 Break. 4:20 Oncolytic Adenovirus Expressing IFN-α Synergistically Potentiates Chemotherapy, Radiation, and Chemoradiation in Pancreatic Cancer Cells. A.O. Salzwedel, C. LaRocca, J. Han, K. Aoki, J. Davydova, M. Yamamoto. University of Minnesota, National Cancer Center Research Institute, Hachioji, Japan. (1064.6) 4:40 cAMP-Phosphodiesterase PDE4D as a Target for Colon Cancer Therapy. A. Boyd, G. Baskar, T. Petty, A. Keeton, G. Piazza, W. Richter. University of South Alabama. (671.11) 5:00 Non-Cannonical Notch Signaling Pathways Regulate Breast Cancer Stem-Like Cells Function in Triple Negative Breast Cancer. F. Hossain, C. Sorrentino, A. Bilyeu, J. Crabtree, A. Pannuti, T. Golde, B. Osborne, L. Miele. LSUHSC, University of Florida and Umass Amherst. (671.6) 5:20 Wrap Up.
TUESDAY PHARMACOLOGY
485. DIVISION FOR BEHAVIORAL PHARMACOLOGY— TEAM SCIENCE FORUM: SCIENTIST CROSSTALK ON CHEMISTRY AND BEHAVIOR Division Symposium (Sponsored by: ASPET Division for Behavioral Pharmacology) Tue. 3:00 pm—McCormick Place Convention Center, W474B Chaired: E. Jutkiewicz and B. Blough Behavioral Pharmacology Professional Development The session will focus on the highly collaborative interactions between medicinal chemists and behavioral pharmacologists in the development and investigation of novel therapeutics. Pairs of speakers will describe findings ranging from chemical design and synthesis to in vivo evaluation of a single class of compounds. Importantly, these teams will demonstrate how scientists from these different fields communicate and educate each other, emphasizing the challenges and successes of these important scientific relationships. This session runs from 3:00 pm–5:30 pm. 3:00
3:50
4:40
Pair 1: Development of GlyT-1 Inhibitors for the Treatment of Psychiatric Disorders. Peter Guzzo, ConSynance Therapeutics, Inc., and Nicholas Moore, Brains-Online. Pair 2: Designing Mixed Efficacy Opioid Ligands with Improved Analgesic Profiles. Henry Mosberg, Univ. of Michigan, and Emily Jutkiewicz, Univ. of Michigan Med. Sch. Pair 3: Optimizing in Vivo Pharmacology of ShortActing Cannabinoid Ligands. Alex Makriyannis, Northeastern Univ., and Carol Paronis, McLean Hosp., Harvard Univ. Med. Sch.
3:30
Inhibition of Neuropilin 1 Signaling in Glioma Associated Macrophages and Microglia Slows Tumor Progression. J.T. Miyauchi, D. Chen, M. Choi, K. Shroyer, D. Selwood, S. Tsirka. Stony Brook University and University College London, United Kingdom. (1063.6) 3:50 Ursolic Acid from Shea Butter Tree (Vitellaria paradoxa) Leaf Extract Synergizes with β-Lactams Against Methicillin-Resistant Staphylococcus aureus. L. Catteau, J. Olson, F. Van Bambeke, J. Leclercq, V. Nizet. Université Catholique de Louvain (UCL), Belgium and University of California San Diego (UCSD). (1000.5) 4:10 11/14-Oxy-DPA, the 12-LOX Derived Metabolites of DPA, Inhibit Platelet Activation Through the cGMPPKG Signaling Pathway. J. Yeung, N. Edokobi, M. Hawley, D. Craven, C. Li, T.R. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. (675.5) 4:30 Treatment with Anti-PD-L1 Antibody Improves Antimicrobial Immunity During Burn Wound Sepsis. N. Patil, L. Luan, E.R. Sherwood. Vanderbilt University Medical Center. (1001.5) 4:50 Drugging the Gut Microbiome for the Treatment of Alcohol-Induced Liver Injury. R.N. Helsley, R.C. Schugar, D. Ferguson, A.D. Gromovsky, C. Neumann, Z. Wang, D. Allende, L.E. Nagy, S.L. Hazen, J.M. Brown. Cleveland Clinic Foundation. (1068.7) 5:10 Awards.
487. DIVISION FOR TRANSLATIONAL AND CLINICAL PHARMACOLOGY— EARLY CAREER FACULTY SHOWCASE Division Oral Session (Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Tue. 5:30 pm— McCormick Place Convention Center, W471A
486. DIVISION FOR TRANSLATIONAL AND CLINICAL PHARMACOLOGY—YOUNG INVESTIGATOR AWARDS PLATFORM SESSION Division Oral Session (Sponsored by: ASPET Division for Translational and Clinical Pharmacology)
Chaired: P.J. Hornby Translational and Clinical Pharmacology This showcase runs from 5:30 pm–6:00 pm. 5:30
Tue. 3:00 pm—McCormick Place Convention Center, W471A Translational and Clinical Pharmacology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:10 Novel Characterization of Docohexanoic Acid and Its 12-LOX Products, 11-HDHE and 14-HDHE on Human Blood Platelets. M. Hawley, D.D. Craven, N. Edokobi, T. Holman, M. Holinstat. University of Michigan Medical School and University of CaliforniaSanta Cruz. (675.4)
5:45
Discontinuation of Chronic RAAS Inhibitor Therapy at Time of Contrast Media Administration Reduces Degree of Kidney Injury in an Animal Model. D.A. Lauver, J.I. Parsh, H.S. Gurm. Michigan State University and University of Michigan Health System (998.2) High-Calorie Diet Induces Vascular and Hemodynamic Abnormalities in Absence of Change in Blood Glucose or Insulin Levels: Modulation by Oral AntiHyperglycemic Drugs. A. El-Yazbi, M. El-Khatib, M. Fouda, F. Sleiman, E. Saad, H. Fouad, A. Eid. Alexandria University, Egypt and American University of Beirut, Lebanon (1068.3)
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PHYSIOLOGY TUESDAY
Physiology 488. APS PRESIDENT’S SYMPOSIUM SERIES: RESEARCH ADVANCES IN SEX/GENDER AND DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES
8:30
DEVELOPMENTAL PROGRAMMING OF DISEASES
8:45
Symposium
9:00
President’s Symposium Series Tue. 10:30 am—McCormick Place Convention Center, W375A
9:15
Chaired: B. Alexander Sex Differences and Women’s Health
9:30
Developmental Programming Hypertension 10:30 An Overview of the Concept of Developmental Programming. Kent Thornburg. Oregon Hlth. and Sci. Univ. 11:00 Actions of Bisphenol A (BPA) and Chemical Used in BPAFree Products on the Reproductive Neuroendocrine System during Early Development. Nancy Wayne. UCLA Sch. of Med. 11:30 The Benjamin Button Approach to Understanding the Developmental Origns of Hypertension. Kate Denton. Monash Univ. 12:00 Epigenetic Consequences of Adverse Fetal Life. Torsten Plosch. Univ. of Groningen.
9:45
490. ATTTACHING PHYSIOLOGY TO THE GENOME: SPOTLIGHT ON CARDIOVASCULAR GENETICS
489. ADVANCES IN RENAL PHYSIOLOGY II
Symposium
Featured Topic
(Cosponsored by: American Society for Human Genetics)
(Sponsored by: Renal Section)
Tue. 8:00 am—McCormick Place Convention Center, W190A
Tue. 8:00 am—McCormick Place Convention Center, W192C Chaired: E. Inscho and A. Polichnowski
Chaired: E. Davis and B. Joe 8:00
Salt Inflammation/Immunity
8:25
Hypertension 8:00
8:15
158
Nox 4 Null Mutation Attenuates Podocyte Calcium Regulation Dysfunction and Kidney Damage in Streptozotocin-Treated Dahl Salt-Sensitive Rats. G. Blass, D. Ilatovskaya, K. Winsor, V. Levchenko, O. Palygin, A.W. Cowley Jr., A. Staruschenko. Medical College of Wisconsin. (716.9) Imaging Renin Granule Exocytosis in Juxtaglomerular Cells by Total Internal Reflection (TIRF) Microscopy. M. Mendez. Henry Ford Hospital. (701.3) A New View of Macula Densa Cell Microanatomy. G. Gyarmati, J. Moon, A. Riquier Brison, J. PetiPeterdi. University of Southern California. (701.12) Administration of Tempol Improves Renal Autoregulation in Ischemia-Reperfusion Induced Acute Kidney Injury. Z. Guan, C. Ryoo, E.W. Inscho. University of Alabama at Birmingham. (1030.6) Tempol Prevents the Enhancement of Angiotensin II Contractions of Afferent Arterioles from Mouse with Reduced Renal Mass. L. Li, E. Lai, Z. Luo, K.K. Griendling, W.K. Taylor, A. Wellsten, W. Welch, C.S. Wilcox. Georgetown University, Zhejiang University, People’s Republic of China, and Emory University. (698.7) Susceptibility to Pressure-Induced Renal Injury in DOCA-Salt vs. Angiotensin II Hypertensive Rats. A.J. Polichnowski, K. Griffin, P. Sethupathi, V. Patel, M. Patel, M. Picken, G. Williamson, A. Bidani. East Tennessee State University, Hines VA Hospital and Loyola University Chicago and Illinois Institute of Technology. (701.2)
Transcriptional Regulation and Therapeutic Targeting of P2X7 Receptors in Diabetic Nephropathy. R.I. Menzies, J.W. Booth, J.J. Mullins, M.A. Bailey, F.W. Tam, J.T. Norman, R.J. Unwin. University of Edinburgh, United Kingdom, UCL, United Kingdom and Imperial College London, United Kingdom. (716.11) Novel CRISPR/Cas9 Mouse Knock-In Model Containing an Alpha-Actinin 4 Mutation Associated with Focal Segmental Glomerulosclerosis Recapitulated Human Kidney Injury and Provides Insight Into How Aberrations in Cytoskeleton Lead to Podocyte Dysfunction. D. Feng, R. Krishnan, A. Benjamin, M.R. Pollak. Beth Israel Deaconess Medical Center and Harvard Medical School. (1031.1)
8:50 9:15 9:40
Characterizing Functional Regulatory Variants in iPSCderived Human Cardiomyocytes. Kelly Frazer. UCSD Sch. of Med. From Genes to Function: Mechanistic Studies of Cardiometabolic Disorders in Mammalian Models. John Hall. Univ. of Mississippi Med. Ctr. Modeling Cardiovascular Disease in Zebrafish for Pathway Annotation and Drug Discovery. Calum MacRae. Brigham and Women’s Hosp. Leveraging GWA’s and Sequence Data from the Clinic in Basic Research. Howard Jacob. HudsonAlpha Inst. for Biotech. Panel Discussion.
TUESDAY PHYSIOLOGY
491. BRAIN SECRETS REVEALED BY OPTOGENETICS/ CHEMOGENETICS APPROACHES
493. ION CHANNELS AND TRANSPORTERS IN HEALTH AND DISEASE Featured Topic
Symposium
(Sponsored by: Cell and Molecular Physiology Section)
(Sponsored by: Neural Control and Autonomic Regulation Section)
Tue. 8:00 am—McCormick Place Convention Center, W192A
Tue. 8:00 am—McCormick Place Convention Center, W196C
Chaired: K.L. Hamilton and E. Rodrigues Ion Channels and Transporters
Chaired: K. Rahmouni and A. De Kloet Neurophysiology Neurobiology 8:00 8:30 9:00
9:30
The C1 Cells Mediate the Protective Effect of Psychological Stress against Ischemic/Reperfusion Renal Injury. Patrice Guyenet. University of Virginia. Dissection of the Role of the Lateral Hypothalamic Neurons in Physiological Regulation. Huxing Cui. University of Iowa. Illumination of Brain Angiotensin Receptor Circuits Reveal an Access Point for Neuroendocrine and Autonomic Control. Annette De Kloet. University of Florida. Oxytocin Activation: A New Target for Improving Autonomic Balance to the Heart. David Mendelowitz. The George Washington University.
492. EXERCISE TRAINING VERSUS METFORMIN FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES Symposium (Sponsored by: Environmental and Exercise Physiology Section) Tue. 8:00 am—McCormick Place Convention Center, W190B Chaired: W.G. Schrage and N. Jenkins Muscle Metabolism 8:00 Exercise and Metformin Interactions on Insulin Sensitivity and Glucose Metabolism. Barry Braun. Colorado State University. 8:30 Exercise and Metformin Interactions on CVD Risk Factors and Inflammation. Steve Malin. University of Virginia. 9:00 Exercise and Metformin Effects on Adipose Tissue and Vasculature. Nathan Jenkins. University of Georgia. 9:30 Exercise Training versus Metformin on NAFLD-Related Outcomes and Hepatic Lipid Metabolism. Scott Rector. University of Missouri-Columbia.
8:00
How the Thick Ascending Limb Works: An Update. Jens Leipziger. Aarhus Univ. 8:30 NKCC Regulates Circadian Rhythm via the ChlorideSensing WNK Kinase. A. Rodan, J. Schellinger, Q. Sun, A. Rothenfluh. University of Utah and University of Texas Southwestern. (1007.12) 8:45 Peter K. Lauf Travel Award Winner Abstract #2 for the Ohio Physiological Society, November 2016. N. Weisleder, D. Halm. Ohio State University Wexner Medical Center and Wright State University Boonshoft School of Medicine. (1007.2) 9:00 Calcium Oxalate (CaOx) Crystal Adhesion/ Agglomeration Dependence of CLC-5 Expression in Renal Epithelial Cells. R. Lorsung, P.C. Harris, J.C. Lieske, M. Chang. Mayo Clinic College of Medicine, University of Minnesota and Twin Cities. (1007.6) 9:15 Reduced Expression of Down-Regulated in Adenoma (DRA) in Murine Enteroid-Derived Monolayers Following Infection with Salmonella. R.R. Jayaratne, B. Lee, E. Lim, K. Barrett, S. Das University of California, San Diego, Korea University, Republic of Korea. (1007.15) 9:30 Functional Studies of TRPM7 —A Candidate Gene for Stillbirth? J. Cartwright, Q. Aziz, S. Harmer, A. Tinker, P. Munroe. Queen Mary University of London, United Kingdom. (1007.21) 9:45 Overexpression of SERCA2a Alters Endoplasmic Reticulum Ca2+ Handling in WKY but Not SHR Cardiac Sympathetic Neurons. A Role for Altered Intracellular Ca2+ Handling in Hypertensive Sympathoexcitation? J. Shanks, N. Herring, D. Li, E. Johnson, D.J. Paterson. Oxford University, United Kingdom and UNMC. (1007.19)
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PHYSIOLOGY TUESDAY
494. AUTOPHAGY: DRIVER OF MICROBIOME COMPOSITION AND INTESTINAL HOMEOSTASIS
495. NEUROGLIAL INTERACTIONS IN HEALTH AND DISEASE Featured Topic
Featured Topic
(Sponsored by: CNS Section)
(Sponsored by: GI and Liver Physiology Section)
Tue. 8:00 am—McCormick Place Convention Center, W193
Tue. 8:00 am—McCormick Place Convention Center, W194B
Chaired: B. Gulbransen Inflammation/Immunity
Chaired: A. Theiss and J. Sun
Neurophysiology
Microbiome Inflammation/Immunity 8:00
8:15
8:30
8:45
9:00
9:15
9:30
160
Lactobacillus reuteri Modulates Dendritic Cells and the Immune Response in Vitro and in Vivo. M.A. Engevik, B.P. Ganesh, C. Visuthranukul, J. Versalovic. Baylor College of Medicine, Texas Children’s Hospital and King Chulalongkorn Memorial Hospital, Thailand. (1041.1) IMP1 Plays a Protective Role in LIN28B-Associated Intestinal Tumorigenesis by Regulating ER Stress and Cell Junction Assembly. P. Chatterji, K. Hamilton, S. Andres, S. Foley, R. Mizuno, A. Castells, M. Cuatrecasas, L. Simon, B. Gregory, B. Madison, A. Rustgi. University of Pennsylvania, IDIBAPS, Spain, University of Barcelona, Spain and Washington University. (1041.2) Autophagy Controls Epithelial Proteolytic Homeostasis of the Intestinal Mucosa. N. Vergnolle, N. Sola Tapias, C. Deraison, C. Blanpied, A. Edir, D. Gilles, B. Chrystelle, F. Barreau. Inserm U-1220, France. (1041.3) Lactic Acid Bacteria Isolated from Korean Kimchi Modulate the Vitamin D Receptor-Autophagy Signaling Pathways. M. Shang, Y. Zhang, R. Lu, Y. Jiao, Y. Xia, C. Kim, S. Kang, J. Sun. Sun Yat-sen University, People’s Republic of China, University of Illinois at Chicago, Dankook University, Republic of Korea, and Georgia State University. (1041.4) Mitophagy Regulation After Diet and Exercise in NonAlcoholic Fatty Liver Disease. M.E. Rosa-Caldwell, M. Harris, J.L. Brown, D.E. Lee, K. Poole, A. Seija, L.A. Brown, R.A. Perry; Jr., T.A. Washington, J.S. Wooten, N.P. Greene. University of Arkansas and Southern Illinois University Edwardsville. (1041.5) The Effect of a Western Diet on Hepatic Autophagy in Age Accelerated SAMP8 Mice. M.P. Harris, M.L. Schaller, D. Umbaugh, K. Sandoval, K.A. Witt, J.S. Wooten. Southern Illinois University Edwardsville. (1041.6) Autophagy and ER Stress in the Pathogenesis of Inflammatory Bowel Diseases. Richard Blumberg. Brigham and Women’s Hospital.
Neurobiology 8:00 8:30
8:45
9:00
9:15 9:30
9:45
Regulation of CNS Inflammation. Francisco Quintana. Brigham and Women’s Hospital. High-Fat Diet Induced Modulation of Glutamatergic Currents in Neurons of the Dorsal Motor Nucleus of the Vagus. C.E. Clyburn, K.N. Browning. Penn State Hershey. (1010.1) Defective Microglia Alters Respiratory Control and Mitochondrial Function in Mice. J. Rousseau, S. Laouafa, M. Tremblay, V. Joseph, R. Kinkead. IUCPQ, Université Laval, Canada, CNRS, UMR 5023-LEHNA, Université Claude-Bernard Lyon1, France, CRCHUQ and Université Laval, Canada. (1010.2) Microglia Promote Age-Dependent Post-Synaptic GluR2 Insertion in the Nucleus Tractus Solitarii Following Neonatal Acute Lung Injury. D.G. Litvin, C.B. Smith, F.J. Jacono. Case Western Reserve University and Louis Stokes Cleveland VA Medical Center. (1010.3) Enteric Glial Cells Acutely Regulate Secretomotor Function in the Mouse Colon. V. Grubisic, B.D. Gulbransen. Michigan State University. (1010.6) Maternal High Fat Diet Induces Myenteric Neuronal Loss and Upregulates Myenteric Glia Prior the Development of Obesity or Inflammation. C. McMenamin, K. Browning. Penn State College of Medicine. (1010.7) Auto-Immunity Targeting the Enteric Nervous System May Cause Constipation in Multiple Sclerosis. E.T. Spear, M.M. Haag, B. Lavoie, A. Applebee, C. Teuscher, G.M. Mawe. University of Vermont. (1010.8)
TUESDAY PHYSIOLOGY
496. EMBRACING THE HETEROGENEITY OF LUNG INJURY: A BEDSIDE TO BENCH TO BEDSIDE PERSPECTIVE
498. NOVEL INSIGHTS IN VASCULAR PATHOPHYSIOLOGY Featured Topic
Symposium
(Sponsored by: Cardiovascular Section)
(Sponsored by: Respiration Section)
Tue. 8:00 am—McCormick Place Convention Center, W196A
Tue. 8:00 am—McCormick Place Convention Center, W196B Chaired: S. Dudek and C. Shaver
Chaired: B. Isakson and P. Bagher 8:00
Ion Channels and Transporters Injury Repair and Regeneration
8:30
Inflammation/Immunity 8:00 8:25 8:45 9:05 9:25
Not a Single Disease State: Molecular Subphenotypes of Lung Injury in Human Trials. Carolyn Calfee. University of California San Francisco. Insult-Specific Glycobiology Signatures of Critical Illness: Impact on Lung Injury. Eric Schmidt. University of Colorado. Distinct Endothelial Responses to Lung Injury Insults: A Role for Apoptosis. Mahendra Damarla. Johns Hopkins University. Distinct Roles of Tissue Factor in Direct and Indirect Acute Lung Injury. Julie Bastarache. Vanderbilt University. An Individualized Approach to ARDS: Where Do We Go from Here? Steven Dudek. University of Illinois Chicago.
497. DEVELOPMENTAL PROGRAMMING OF VERTEBRATE HEALTH AND DISEASE BY HYPOXIA
8:45
9:00
9:15
Symposium (Sponsored by: Comparative & Evolutionary Physiology Section)
9:30
Tue. 8:00 am—McCormick Place Convention Center, W192B Chaired: G. Galli 8:00 8:30 9:00 9:30
Heart Disease Links to Fetal Hypoxia in Mammals: An Intergenerational Perspective. Dino Giussani. Univ. of Cambridge. Hypoxic Developmental Programming of Cardiovascular Function in Avian Models. Isa Lindgre. Oregon Health and Science University. Analyzing the Effects of Hypoxia on Fish Cardiovascular Development. Brian Bagatto. University Akron. Hypoxic Programming of Fetal Sheep Coronary Development. Sonnet Jonker. Oregon Health and Science University.
9:45
Revisiting Vascular Mineralocorticoid Receptors in the Coronary Circulation. Shawn Bender. University of Missouri. Characterization of Transendothelial Insulin Efflux as a Barrier to Insulin Action in Vivo. I.M. Williams, F.A. Valenzuela, A.R. Mezo, J.D. Young, K.S. Wells, D.H. Wasserman. Vanderbilt University and Lilly Research Laboratories. (1015.26) Smooth Muscle-Specific Deletion of Cullin-3 Causes Severe Early Onset Hypertension. L.N. Agbor, A.R. Nair, J. Wu, D.R. Davis, H.L. Keen, F.W. Quelle, J.A. McCormick, J.D. Singer, C.D. Sigmund. University of Iowa, Oregon Health and Science University and Portland State University. (1015.7) A Novel Functional Variant of nNOS Mediates Anoxic Injury in Brain Microvascular Endothelial Cells via Mitochondrial Superoxide Generation. V.N. Sure, A.L. Chen, N.R. Peterson, N.P. Jain, I. Rutkai, I. Merdzo, D.W. Busija, P.V. Katakam. Tulane University School of Medicine. (1015.34) Depletion of Caveolin-1 in Lung Vasculature and Increase in Caveolin-1 Positive Circulating Extracellular Vesicles as Early Biomarkers of Endothelial Injury. S. Santos Oliveira, M. Castellon, R.F. Machado, M.H. Elliott, M.G. Bonini, R.D. Minshall. University of Illinois at Chicago and University of Oklahoma Health Sciences Center. (1015.25) Impaired Perivascular Nerve Function of Mesenteric Arteries in a Murine Model of Inflammatory Bowel Disease. E.M. Boerman, M.L. Hart, C.L. Franklin, S.S. Segal. University of Missouri and Dalton Cardiovascular Center. (1015.5) Loss of Endothelial Fto Is Protective Against Metabolic Disease. N. Krüger, L.A. Biwer, M.E. Good, U. Rüther, B.E. Isakson. Heinrich Heine University of Düsseldorf, Germany, Robert M Berne Cardiovascular Research Center, University of Virginia and University of Virginia. (1015.15)
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499. SEX, STRESS, AND EPIGENETIC CONTRIBUTIONS IN AUTONOMIC REGULATION
500. MECHANISMS AND INFLUENCES ON CELL SIGNALING
Featured Topic
Featured Topic
(Sponsored by: Neural Control and Autonomic Regulation Section)
(Sponsored by: Cell and Molecular Physiology Section) Tue. 10:30 am—McCormick Place Convention Center, W194B
Tue. 10:30 am—McCormick Place Convention Center, W193
Chaired: R. Worrell
Chaired: S. Sriramula Neurophysiology Genetics, Epigenetics, MicroRNA Neurobiology 10:30 Epigenetic Regulation of Redox State Contributes to Cardio-Respiratory Pathologies in a Rodent Model of Sleep Apnea. Nanduri Prabhakar. University of Chicago. 11:00 Prenatal Exposure to Mild High Fat Diet Paradoxically Leads to Improvement in Cardio-Metabolic Function in the Offspring. S. Mukerjee, Y. Zhu, J. Zhao, A. Zsombok, E. Lazartigues. LSUHSC, University of Florida and Tulane University. (1057.2) 11:15 Acute Inhibition of HDACs After MI Leads to Low Inflammatory Profile: Implications for Post-MI Angiogenesis. S. Veeranki, S.C. Tyagi. University of Louisville. (1057.1) 11:30 Presence of an Inhibitory Glycinergic Current in Dorsal Motor Nucleus of the Vagus Neurons Regulating Gastric Functions in Offspring of Maternal High Fat Diet Rats. C. McMenamin, R. Travagli, K. Browning. Penn State College of Medicine. (864.2) 11:45 Glutamatergic Neurons in the Dorsal Hypothalamic Area Dissociate Thermogenesis from Heat Conserving Pathways During Stress Responses. N.L. Machado, S. Abbott, P. Fuller, M. Fontes, C. Saper. Beth Israel Deaconess Medical Center—Harvard Medical School, Heart Research Institute, Sydney and Federal University of Minas Gerais, Brazil. (866.1) 12:00 Aerobic Fitness Influences Autonomic Support of Blood Pressure in Premenopausal, but Not Postmenopausal Women. S.E. Baker, J.K. Limberg, W.T. Nicholson, T.B. Curry, J.N. Barnes, M.J. Joyner. Mayo Clinic and University of Wisconsin. (1056.4) 12:15 Hypertensive Young Adult Female Obese Zucker Rats (OZR) Do Not Develop the Impaired Baroreflexes or Reduced Activation of the NTS Observed in Male OZR. P. Chaudhary, G. Fu, A. Schreihofer. UNT Health Science Center. (1056.6)
Microbiome 10:30
Defining the Regulatory Role of Lipid Raft Microdomains During T Cell Receptor Activation. C.C. Osigwe, A.D. Levine. Case Western Reserve University. (1005.2) 10:45 ATP and Extracellular Calcium Regulates Differentially the Phagocytosis of S. aureus and C. glabrata by Macrophages. G. Pérez, C. Hernandez-Silva, J. Arreola, P. Pérez-Cornejo. UASLP, Mexico. (880.8) 11:00 The Host Engulfment Pathway in Enteroids Is Linked to Intestinal Inflammation Following Bacterial Infection. S. Das, E. Lim, K. Suarez, P.B. Ernst, K.E. Barrett. University of California San Diego. (695.2) 11:15 Show Me the Way: Ethanolamine Sensing is a Bacterial GPS for Navigating Host Niches. Melissa Kendall. University of Virginia School of Medicine. 11:45 25(OH)D3 Treatment Improves Inflammatory Pathway on Monocytes Lineage (U937) in Uremic Environment. R.B. de Oliveira Brito, J.F. Rebello, W.R. ‘dos Santos Oliveira, C.C. Grabulosa, Y.S. Matos, C.S. Malta, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil. (695.4) 12:00 Molecular Mechanisms Underlying Angiotensin II-Induced Angiotensin Converting Enzyme 2 Internalization and Degradation. B. Ogunlade, S. Sriramula, E. Lazartigues, J.J. Guidry, C.M. Filipeanu. Howard University and Louisiana State University Health Sciences Center. (1005.5) 12:15 Modulation of Lemur Tyrosine Kinase 2 (LMTK2) Expression by TPA Response Elements. I.A. Dey, N.A. Bradbury. Chicago Medical School. (1005.4)
501. IMPACT OF DAIRY BASED NUTRITIONAL INTERVENTIONS ON CARDIOMETABOLIC HEALTH Featured Topic (Sponsored by: Environmental and Exercise Physiology Section) Tue. 10:30 am—McCormick Place Convention Center, W192B Chaired: L. Alexander and B. Miller Microbiome 10:30
Potential Benefits of Dairy Product Intake on Muscle Metabolic Health. Adam Konopka. Colorado State University. 11:00 Whey Protein Improves Glucose Uptake Following Exercise via DPP-IV and IL-6. L.E. Neidert, H.A. Kluess. Auburn University. (1035.3)
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TUESDAY PHYSIOLOGY 11:15
High-Intensity Interval Training with or Without PostExercise Milk Consumption Improves Cardiovascular Function in Patients with Type 2 Diabetes. M.E. Francois, C. Durrer, J. Little. University of British Columbia Okanagan, Canada. (1035.2) 11:30 Effects of Whole Milk and Full-Fat Dairy Products on Blood Pressure in Patients with Elevated Blood Pressure. S. Roy, B. Baker, S. LaPierre, W. Geary, L. Delfausse, E. Pasha, H. Tanaka. The University of Texas at Austin. (1035.1) 11:45 Dairy Cheese Ingestion Does Not Improve Acute SodiumInduced Cutaneous Microvascular Dysfunction Through Arginase or Inducible Nitric Oxide Synthase Mechanisms. B.K. Alba, A.E. Stanhewicz, W. Kenney, L.M. Alexander. The Pennsylvania State University. (1035.4) 12:00 Exercise and Dairy Protein Interactions in the Treatment of Obesity. S. Trottier. University of Guelph, Canada. (1035.5) 12:15 Dairy Protein and Sodium-Induced Vascular Dysfunction1. Anna Stanhewicz. The Penn State Univ.
502. SODIUM HOMEOSTASIS IN METABOLIC SYNDROME: SORTING OUT NEW AND OLD PLAYERS Symposium (Sponsored by: Water and Electrolyte Homeostasis Section) Tue. 10:30 am—McCormick Place Convention Center, W196C Chaired: C. Ecelbarger and S. Tiwari Ion Channels and Transporters Microbiome Salt 10:30 The Renal Thick Ascending Limb and ObesityAssociated Sodium Retention: Culprit or Innocent ByStander? Dexter Lee. Howard University. 11:00 Integrative Sodium Reabsorption along the Renal Tubule: Global Impact of Metabolic Syndrome. Carolyn Ecelbarger. Georgetown University. 11:30 Regulation of ENaC by Insulin and IGF1: Are They Distinguishable? Alexander Staruschenko. Medical College of Wisconsin. 12:00 Metabolic Syndrome, Insulin, and Renal Sodium Handling. Vivek Bhalla. Stanford Univ. Sch. of Med.
503. NEW INSIGHTS INTO THE ROLE OF HYPOTHALAMIC PEPTIDES IN THE CONTROL OF APPETITE AND ENERGY BALANCE Featured Topic (Sponsored by: CNS Section) Tue. 10:30 am—McCormick Place Convention Center, W196A Chaired: J. Blevins and Z. Song Neurophysiology Energy Homeostasis Neurobiology 10:30
Role of Hypothalamic Oxytocin Signaling in the Control of Appetite and Energy Balance. Zhilin Song. University of Colorado. 11:00 The Effects of Glutamate on Oxytocin Release. Y.A. Badmus, R. Cantley, J.W. Hill. University of Toledo College of Medicine. (1038.7) 11:15 Medullary Reticular GABAergic Neurons That Mediate Hunger Responses Induced by Hypothalamic Neuropeptide Y. Y. Nakamura, Y. Yanagawa, S.F. Morrison, K. Nakamura. Nagoya University Graduate School of Medicine, Japan, Gunma University Graduate School of Medicine, Japan, Oregon Health & Science University and JST, Japan. (1040.4) 11:30 Endoplasmic Reticulum Stress in the Paraventricular Nucleus of the Hypothalamus During Diet-Induced Non-Alcoholic Fatty Liver Disease. K. Blackmore, J. Jeong, C.N. Young. George Washington University and School of Medicine and Health Sciences. (1038.5) 11:45 TNFα Exposure Induces Neuroinflammation and Insulin Resistance in a Rat-Derived Hypothalamic Cell Model, rHypoE-7. M.N. Clemenzi, M.E. Aljghami, L. Wellhauser, D.D. Belsham. University of Toronto, Canada. (1038.4) 12:00 Protein Tyrosine Phosphatase 1b (PTP1B) Deficiency in Proopiomelanocortin (POMC) Neurons Attenuates Body Weight, Fat Mass and Liver Lipid Accumulation in Mice Fed a High Fat Diet. N. Aberdein, Z. Wang, J.M. do Carmo, T. Fang, J.E. Hall. University of Mississippi Medical Center. (1038.6) 12:15 AT1A Receptors in AgRP Neurons Disinhibit αMSH Neurotransmission. K.E. Claflin, D.A. Morgan, K. Rahmouni, J.L. Grobe. (1038.1)
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504. REGULATION OF GLOMERULI PHYSIOLOGICAL FUNCTION: PODOCYTES AND BEYOND Symposium (Sponsored by: Renal Section) Tue. 10:30 am—McCormick Place Convention Center, W192C Chaired: D. Ilatovskaya and J. Reiser
507. KALEY LECTURE FEATURED TOPIC: THE COMPLICATIONS OF DIABETES AND THE ROLE OF INFLAMMATION: MECHANISMS AND THERAPEUTIC OPPORTUNITIES Featured Topic (Cosponsored by: Cardiovascular Section and Microcirculatory Society)
Ion Channels and Transporters
Tue. 10:30 am—McCormick Place Convention Center, W190B
Hypertension
Chaired: A.M. Schmidt
Salt
Inflammation/Immunity
10:30 Glomerular Endothelium and its Interactions with Podocytes. Susan Quaggin. Northwestern University. 11:00 Using 2-Photon Microscopy to Understand Albuminuria. Bruce Molitoris. Indiana University. 11:30 Role of TRPC Channels in the Pathobiology of Podocytes. Oleg Palygin. Medical College of Wisconsin. 12:00 Proteostatic Mechanisms in Glomerular Pathophysiology. Markus Rinschen. University of Cologne.
505. MECHANISMS OF STIFFENING IN LARGE AND SMALL VESSELS: FROM THE CYTOSKELETON TO THE EXTRACELLULAR MATRIX Symposium (Sponsored by: Cardiovascular Section) Tue. 10:30 am—McCormick Place Convention Center, W196B Chaired: L. Martinez-Lemus and G. Meininger 10:30
Extracellular Matrix, Aortic Fibrosis and Hypertension. David Harrison. Vanderbilt University Medical Center. 11:00 Aging and Arterial Stiffening. Stephen Vatner. Rutgers New Jersey Medical School. 11:30 Diabetes and Microvascular Remodeling. Aaron Trask. Nationwide Children’s Hospital. 12:00 Mineralocorticoid Receptor Signaling and Arterial Stiffening. Jim Sowers. University of Missouri.
506. JULIUS H. COMROE, JR. DISTINGUISHED LECTURESHIP OF THE APS RESPIRATION SECTION Lecture Tue. 10:30 am—McCormick Place Convention Center, W190A 10:30 Lung and Muscle Heterogeneity: Consequences for Oxygen Transport Limitation. Peter Wagner. University of California, San Diego.
10:30 RAGE Signal Transduction Mediates Chronic Inflammation in Obesity, Diabetes and its Complication: Mechanisms and Therapeutic Opportunities. Ann Marie Schmidt. New York Univ. Med. Col. 11:30 Smooth Muscle Cells Are the Source of Heart FailureCausing Methylglyoxal in Diabetes Mellitus. K.R. Bidasee, F. Alomar, R. Fang, J.L. Cox, G.J. Rozanski, J. Singh. University of Nebraska Medical Center, University of Dammam, Saudi Arabia, Shandong University School of Medicine, People’s Republic of China, and University of Central Lancashire, United Kingdom. (1013.1) 11:45 Leptin Replacement Therapy Restores Endothelial Function in Mouse Models of Congenital and Acquired Lipodystrophy by Reducing NOX-1 and NOX-4-Derived Reactive Oxygen Species. T. Bruder do Nascimento, S. Kennard, W. Chen, E.J. Belin de Chantemèle. Augusta University. (1013.2) 12:00 Myeloid-Derived Suppressor Cells in Adipose Tissue Homeostasis. K.B. Stivers, P. Chilton, J. Beare, J. Dale, C.L. Kaufman, J.B. Hoying. Cardiovascular Innovation Institute, University of Louisville and Christine M Kleinert Institute. (1013.3) 12:15 Exercise Reverses Metabolic Syndrome Perivascular Adipose Tissue Impairment of Aortic Relaxation. E. DeVallance, K. Branyan, K. Lemaster, S. Clayton, C. Killmer, J. Frisbee, P. Chantler. West Virginia University and Western University, Canada. (1013.4)
508. THE HOT ZONE: SKELETAL MUSCLE CHANGES CAUSED BY HYPERTHERMIA AND HEAT STRESS Featured Topic (Sponsored by: Muscle Biology Group) Tue. 10:30 am—McCormick Place Convention Center, W192A Chaired: J. Selsby Muscle Metabolism 10:30 Metabolic Changes in Skeletal Muscle Caused by Prolonged Heat Stress. Robert Rhodes. Virginia Tech University.
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TUESDAY PHYSIOLOGY 11:00
A Single Bout of Heat Stress Treatment Increases Nrf2 and Its Target Genes in Mouse Skeletal Muscle. Y. Tamura, Y. Kitaoka, K. Nakazato, H. Hatta. York University, Canada, Nippon Sport Science University, Japan and The University of Tokyo, Japan. (1023.1) 11:15 Hyperthermia and Extracellular Hyperosmolality Affect Sarcolemmal Damage and Protein Oxidation in Mammalian Skeletal Muscle in Vitro. O. Laitano, A.J. Mattingly, G.P. Robinson, C.K. Garcia, T.L. Clanton. University of Florida and Federal University of Vale do São Francisco, Brazil. (1023.2) 11:30 Effect of Core Temperature During Exercise on Markers of Muscle Injury and Oxidative Stress. J. Starnes, T. Herberg, K. Lee, L. Hixson, L. Vervaecke, A. Goldfarb. UNC Greensboro. (1023.3) 11:45 Prolonged Heat Stress Altered Autophagy Signaling in Oxidative Skeletal Muscle. J. Selsby, S. Ganesan, A.J. Brownstein, N.K. Gabler, S.C. Pearce, L.H. Baumgard, R.P. Rhoads. Iowa State University and Virginia Tech. (1023.4) 12:00 Integrity of Intestinal Mucosa and Serum Concentration of Some Metabolites in Pigs Exposed to Acute and Chronic Heat Stress. A. Morales, N. Vásquez, T. Gómez, N. Ibarra, H. Bernal, L. Rodríguez, M. Cervantes. Universidad Autónoma de Baja California, Mexico and Universidad Autónoma de Nuevo León, Mexico. (1018.8) 12:15 A Single Bout of Cryotherapy Does Not Alter the Transcriptome or Metabolome of Human Skeletal Muscle. D.C. Sarver, K.B. Sugg, N.P. Disser, E.R. Siblinsky Enselman, C.L. Mendias. University of Michigan. (1023.5)
511. TWENTY YEARS OF PHYSIOLOGICAL GENOMICS Symposium (Sponsored by: History of Physiology Group) Tue. 3:15 pm—McCormick Place Convention Center, W190B Chaired: M.R. Garrett and A.S. Greene Genetics, Epigenetics, MicroRNA 3:15
Introductory Remarks. Andrew Greene. Med. Col. of Wisconsin. 3:20 The Impact of Physiological Genomics on The American Physiological Society. Martin Frank. APS. 3:30 The Impact of Physiological Genomics on CV/Renal Physiology. Allen Cowley. Med. Col. of Wisconsin. 3:55 Physiological Genomics in GI Physiology. Jason Mills. Washington Univ. Sch. of Med. 4:20 Physiological Genomic Approaches: From Rats to Humans. Howard Jacob. HudsonAlpha Inst. for Biotechnology. 4:45 The Future Avatar of Physiological Genomics? Bina Joe. Univ. of Toledo.
512. HANS USSING LECTURE FEATURED TOPIC Featured Topic (Sponsored by: Epithelial Transport Group) Tue. 3:15 pm—McCormick Place Convention Center, W192A
509. HISTORY OF PHYSIOLOGY LECTURE
1:00
Chaired: J. Klein
Lecture
Ion Channels and Transporters
(Sponsored by: History of Physiology Group)
Hypertension
Tue. 1:00 pm—Hyatt Regency McCormick Place Hotel, Regency Ballroom A
Salt
The XIIIth International Physiological Congress in Boston in 1929: American Physiology Comes of Age. Jack Rall. Ohio State Univ.
510. ROBERT M. BERNE DISTINGUISHED LECTURESHIP OF THE APS CARDIOVASCULAR SECTION
3:15 4:00
4:15
Lecture Tue. 2:00 pm—McCormick Place Convention Center, W190A 2:00
Astronauts, Athletes, and Aging. A TripTik Guide to the Cardiovascular Adaptation to Physical Activity. Benjamin Levine. Texas Health Presbyterian Hospital Dallas.
4:30
Hans Ussing Lecture: Imaging Renal and Intestinal Phosphate Transporter Dynamics. Moshe Levi. University of Colorado. Regulated Expression of the Na+/K+-ATPase Pump in Colonic Epithelium by Bile Acids. J.F. Borg, J. Yde, Q. Wu, N. Lajczak, S. Keely, R.A. Fenton, H. Moeller. Aarhus University, Denmark and Royal College of Surgeons in Ireland, Ireland. (856.10) Intestine-Specific Dual Oxidase Deficiency Lacks ATPP2Y-Mediated Luminal H2O2 Production in Mice. K. Maruta, Y. Akiba, I. Kaji, J.D. Kaunitz. UCLA & WLA VAMC. (856.20) Stimulation of Sweet Taste Receptors Expressed in the Kidney Enhance Surface NKCC2 Levels in Thick Ascending Limbs (TALs). G. Ares, P. Caceres, K.M. Kassem, P.A. Ortiz. Henry Ford Health System. (856.16)
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5:00
The Epithelial Sodium Channel (ENaC) α- and γ-Subunits Are Cleaved by Furin in Human Kidney. R.Z. Langkilde, M.K. Mikkelsen, K. Skjødt, R. Zamani, N. Marcussen, B. Jensen, P. Svenningsen. University of Southern Denmark, nstitute of Molecular Medicine, Denmark, Institute of Molecular Medicine, Denmark, Odense University Hospital, Denmark, University of Southern Denmark and Odense University Hospital, Denmark. (856.3) A Cysteine-Rich Hydrophobic Motif in KS-WNK1 Regulates WNK Body Formation. C.R. BoydShiwarski, D.J. Shiwarski, L.J. Nkashama, A. Roy, D.B. Stolz, M. Puthenveedu, A.R. Subramanya. University of Pittsburgh and Carnegie Mellon University. (856.8)
5:00
514. MULTI-OMICS TO STUDY THE CELLULAR PATHOPHYSIOLOGY OF NEURODEGENERATIVE DISEASES Symposium
513. THE INTEGRATED PHYSIOLOGICAL RESPONSE TO HEAT STRESS IN VULNERABLE POPULATIONS
(Sponsored by: Cell and Molecular Physiology Section) Tue. 3:15 pm—McCormick Place Convention Center, W194B
Featured Topic
Chaired: S. Pimplikar
(Sponsored by: Environmental and Exercise Physiology Section)
Neurophysiology Neurobiology
Tue. 3:15 pm—McCormick Place Convention Center, W193 Chaired: M. Sawka
3:15
Physiology of Extreme Environments 3:15 3:45
4:00
4:15
4:30
4:45
166
Neural and Cardiovascular Responses to Heat Stress in the Elderly. Daniel Gagnon. Univ. of Montreal. Prior Infection and Prior Heat Illness as Risk Factors for Exertional Heat Stroke. M.A. King, M.D. Ward, C.H. Gabrial, G.N. Audet, B. Adams, L.R. Leon. US Army Research Institute for Environmental Medicine and Defense Health Agency. (1018.4) Impact of Air Temperature on Core Temperature Regulation During Exercise Using a Simulated Burn Injury Model. M.N. Cramer, G. Moralez, K. Kouda, D. Gagnon, C.G. Crandall. Institute for Exercise and Environmental Medicine, Wakayama Medical University, Japan and Montreal Heart Institute and Université de Montréal, Canada. (1018.9) Preserved Tolerance to Lower-Body Negative Pressure During Heat Stress in Individuals with Multiple Sclerosis. M. Huang, D.R. Allen, D.M. Keller, P.J. Fadel, E.M. Frohman, S.L. Davis. Southern Methodist University, University of Texas at Arlington and University of Texas Southwestern Medical Center. (1018.11) Exaggerated Hemodynamic Responses Upon the Initiation of Thermoregulatory Behavior in “At Risk” Older Adults. Z.J. Schlader, G.L. Coleman, J.R. Sackett, S. Sarker, C.L. Chapman, D. Hostler, B.D. Johnson. University at Buffalo. (1018.1) Arginase Inhibition and Low-Dose Sodium Nitroprusside Administration Do Not Influence Heat Loss Responses During Exercise in Aged Humans. R.D. Meade, N. Fujii, L.M. Alexander, J.C. Louie, P. Boulay, R.J. Sigal, G.P. Kenny. University of Ottawa, Canada, University of Tsukuba, Japan, Pennsylvania State University, University of Sherbrooke, Canada and University of Calgary, Canada. (1018.2)
Whole-Body Heat Stress Does Not Appear to Reduce β1-Adrenergic Responsiveness in Heat Stressed Older Individuals. G. Moralez, K. Kouda, M. Hieda, E. Hardin, S. Sarma, S.A. Romero, M.N. Cramer, D. Gagnon, A.N. Adams, M.F. Jaffery, C.G. Crandall. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Wakayama Medical Center, Japan, Japan and Montreal Heart Institute and Université de Montréal, Canada. (1018.12)
3:45 4:15 4:45
Genomic Approaches Toward a Greater Understanding of Alzheimer’s Disease. Alison Goate. Icahn School of Medicine at Mount Sinai. De-Mystifying Microglia during Neurodegeneration Using Transcriptomic and Epigenomic Approaches. TBD. Multiscale Network Models of Alzheimer’s Disease. Bin Zhang. Icahn School of Medicine at Mount Sinai. Blood Metabolite Markers of Alzheimer’s Disease: Promise and Challenges. Madhav Thambisetty. National Institute on Aging, NIH.
515. CENTRAL NEUROMODULATION IN THE CONTROL OF BREATHING Featured Topic (Sponsored by: Respiration Section) Tue. 3:15 pm—McCormick Place Convention Center, W196C Chaired: A.J. Garcia and G. Mitchell Neurophysiology Ion Channels and Transporters Neurobiology 3:15 3:35
3:55
Contribution of the Serotonin System in Respiratory and Autonomic Dysregulation in Premature Infants. JeanCharles Viemari. CNRS-Aix Marseille Université. Kir5.1 Channel Disruption Alters Acute and Chronic pH Regulation, Central 5-HT, and Causes Audiogenic Seizures. Matthew Hodges. Medical College of Wisconsin. Questions for Invited Speakers.
TUESDAY PHYSIOLOGY 4:00 Embryonic Rhombomere Hindbrain Patterning Delineates Distinct Functional Neuron Populations in the Adult Central Noradrenergic System. J.J. Sun, M. Key, V.K. Martinez, F. Saldana Morales, P. Zhu, R.S. Ray. Baylor College of Medicine and University of North Carolina School of Medicine. (1053.8) 4:15 Genetic Deletion of Mu Opioid Receptors from Kölliker-Fuse Neurons Reduces MorphineInduced Respiratory Depression. E.S. Levitt, J.M. Bissonnette, B. Kieffer. University of Florida, Oregon Health & Science University, Douglas Research Centre and McGill University, Canada. (1053.17) 4:30 Mechanisms of Cross-Talk Inhibition Between Phrenic Motor Facilitation Elicited by 5-HT2B and 5-HT7 Receptors. R.R. Perim, D.P. Fields, G.S. Mitchell. University of Florida. (1053.14) 4:45 5HT Depletion Blunts Arousal and Chemoreflex Responses Coupled with Breathing Instability and Cardiac Dysfunction in Mice. D. Komnenov, A. Pop, D. Kuhn, J. Mateika. Wayne State University School of Medicine and John D. Dingell VA Medical Center. (1053.6) 5:00 Thyroid Hormone Deficiency Potentiates GABAergic Inhibition of the Brainstem Respiratory Network in Newborn Rat. J. Rousseau, L. Tenorio, R. Kinkead. Université Laval, Canada. (1053.10)
517. EXERCISE INTOLERANCE IN METABOLIC, PULMONARY AND CARDIOVASCULAR DISEASES: DID WE FORGET THE BRAIN?
516. CENTRAL GLP-1 RECEPTORS IN THE REGULATION OF ENERGY HOMEOSTASIS
4:45
Symposium (Sponsored by: Endocrinology and Metabolism Section) Tue. 3:15 pm—McCormick Place Convention Center, W192B Chaired: W. Langhans Energy Homeostasis 3:15 3:45 4:15 4:45
Vagal Neuropeptide CART is Required to Mediate Physiological Effects of Gut GLP1. Guillaume De Lartigue. Yale. Emerging Role of Endogenous Central GLP-1 in Brown Adipose Tissue Thermogenesis. Shin Lee. ETH Zurich. Insights into the Cellular and Molecular Signaling Events of the Central GLP-1 Receptor. Matthew Hayes. University of Pennsylvania. Neural Substrates Engaged by GLP-1 to Impact on Feeding and Reward: Unexpected Role of Interleukins and Sex Steroids. Karolina Skibicka. University of Gothenburg.
Symposium (Sponsored by: Integrative Physiology Symposium Series) Tue. 3:15 pm—McCormick Place Convention Center, W375A Chaired: P. Brassard and D.M. Bailey Neurophysiology Oxygen Transport Neurobiology 3:15 3:45 4:15
Cerebral Blood Flow and Oxygenation in Humans: Dynamic Evaluation and Regulation during Exercise. Damian Bailey. University of South Wales. Cerebral Blood Flow and Oxygenation during Exercise in Patients with Heart Failure and Pulmonary Arterial Hypertension. Patrice Brassard. Université Laval. Cerebral Blood Flow and Oxygenation During Exercise in Patients With a Combination of Chronic Obstructive Pulmonary Disease and Heart Failure. Mayron Oliveira. Federal University of São Paulo. Cerebral Blood Flow and Oxygenation during Exercise in Patients with Type 2 Diabetes. Johannes Van Lieshout. University of Amsterdam.
518. ROLE OF CNS OSMOSENSORY NETWORKS IN THE REGULATION OF CARDIOVASCULAR FUNCTION IN HEALTH AND DISEASE Symposium (Sponsored by: CNS Section) Tue. 3:15 pm—McCormick Place Convention Center, W196A Chaired: J.E. Stern Neurophysiology Hypertension Salt 3:15 Network Plasticity in Baroreceptor Control of Magnocellular Vasopressin Neurons. Charles Bourque. McGill University. 3:45 Interfacing Osmosensitive Sympathoexcitatory Neurons with the Brainstem Sympathetic Rhythm Generating Network. Glenn Toney. University of Texas Helath Science Center.
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PHYSIOLOGY TUESDAY 4:15
4:45
Mechanistic Insights into Purinergic Signaling at Hypothalamus Level in the Control of Salt-Induced Sympathoexcitation. Vagner Antunes. University of Sao Paulo. Osmotically-Driven Dendritic Release of VP and Its Impact on Hypothalamic Sympathetic Outflow. Javier Stern. Georgia Regents University.
519. HORACE W. DAVENPORT DISTINGUISHED LECTURESHIP OF THE APS GASTROINTESTINAL AND LIVER PHYSIOLOGY SECTION Lecture Tue. 3:15 pm—McCormick Place Convention Center, W190A Inflammation/Immunity 3:15
Why the GI Tract Does Not Digest Itself: A DavenportInspired Journey. John Wallace. Antibe Therapeutics and University of Calgary.
520. SEX DIFFERENCES IN DIABETES, OBESITY AND BLOOD PRESSURE CONTROL Symposium Sex/Gender Research Interest Group Tue. 3:15 pm—McCormick Place Convention Center, W192C Chaired: G. Kararigas and S. Lindsey Sex Differences and Women’s Health Energy Homeostasis Hypertension 3:15 3:45 4:15 4:45
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Novel Mechanisms of Antidiabetic Actions of Estrogens in Women. Frank Mauvais-Jarvis. Tulane Univ. Impact of Menopause on the Disease Risk of NonAlcoholic Fatty Liver Disease. Ayako Suzuki. Duke Univ. Obesity-Induced Increases in Sympathetic Nerve Activity: Sex Matters. Virginia Brooks. University of Oregon. Aging and Role of SNA in Blood Pressure Control in Women. Nishi Charkoudian. USARIEM, Natick.
521. AUGUST KROGH DISTINGUISHED LECTURESHIP OF THE APS COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY SECTION Lecture (Supported by Novo Nordisk Fonden) Tue. 3:15 pm—McCormick Place Convention Center, W196B 3:15
Developmental Plasticity, Epigenetics and Evolution: A Comparative Physiologist’s Od(d)yssey. Warren Burggren. University of North Texas.
522. APS BUSINESS MEETING Business Meeting APS Tue. 5:45 pm—McCormick Place Convention Center, W375A
WEDNESDAY BIOCHEMISTRY
WEDNESDAY, APRIL 26 Biochemistry and Molecular Biology 523. ASBMB-MERCK AWARD
526. MOLECULAR QUALITY CONTROL
Award Lecture
Symposium
(Sponsored by: Merck)
Wed. 10:00 am—McCormick Place Convention Center, W184BC
Wed. 8:45 am—McCormick Place Convention Center, W183AB 8:45 Introduction. 8:50 523.1 Proteostasis Function and Disfunction: The Delicate Art of Maintaining a Healthy Proteome. J. Frydman. Stanford University.
Chaired: D. Ron
9:15 Introduction. 9:20 524.1 Structure-Based Discovery of New Chemotypes Conferring New Biology. B. Shoichet. University of California at San Francisco.
10:00 526.1 Regulation of Translational Fidelity and Neurodegeneration. S.L. Ackerman. UCSD and HHMI. 10:25 526.2 A Versatile Chaperone Network Promoting the Aggregation and Disaggregation of Misfolded Proteins. B. Bukau, N. Nillegoda, A. Wentink, S. Ungelenk, C. Ho, A. Mogk. Zentrum für Molekulare Biologie der Universität Heidelberg, Germany. 10:50 526.3 Structures and Functions of the Ribosome Quality Control Complex or RQC. A. Frost. University of California at San Francisco. 11:15 526.4 RNA Decay and Quality Control by the Eukaryotic RNA Exosome. C.D. Lima. Memorial Sloan Kettering Cancer Center/HHMI. 11:40 526.5 Tuning an Endoplasmic Reticulum Chaperone to the Cell’s Needs. D. Ron. University of Cambridge, United Kingdom.
525. LOW COMPLEXITY DOMAIN PROTEINS AND THE MAKING OF GERM CELLS
527. NEW INSIGHTS IN REGULATED LIPID METABOLISM
524. DELANO AWARD FOR COMPUTATIONAL BIOSCIENCES Award Lecture Wed. 9:15 am—McCormick Place Convention Center, W183AB
Symposium
Symposium
Wed. 10:00 am—McCormick Place Convention Center, W183C
Wed. 10:00 am—McCormick Place Convention Center, W185BC
10:00 525.1 RNA Granule Organization. R. Lehmann, T. Trcek, M. Grosch, H. Shroff, T. Lionnet. Skirball Institute, NYU School of Medicine, HHMI, National Institute of Biomedical Imaging and Bioengineering, Janelia Research Campus and Howard Hughes Medical Institute. 10:30 525.2 Organelles Without Membranes: Intrinsically Disordered Proteins Bring Order to the Cytoplasm. G. Seydoux, J. Smith, D. Calidas, H. Schmidt, D. Rasoloson. Johns Hopkins University School of Medicine and HHMI. 11:00 525.3 A Liquid Crystalline Interface Between Chromosomes Regulates Meiotic Recombination. A.F. Dernburg, S. Köhler, L. Zhang, W.T. Stauffer, J.D. Robinson, O. Rog. University of California, Berkeley, HHMI and University of Utah. 11:30 525.4 Amyloid-Mediated Translational Control Is Required for Meiosis. L.E. Berchowitz, M.R. Walker, G.L. Kabachinski, T.U. Schwartz, A. Amon. Massachusetts Institute of Technology, HHMI.
Chaired: R. Zechner 10:00 527.1 The Role of Intracellular Lipolysis in Thermogenesis and Metabolic Disease. R. Zechner, M. Schweiger, R. Breinbauer, R. Zimmermann. University of Graz, Austria and Graz University of Technology, Austria. 10:30 527.2 New Insights Into Intravascular Lipolysis and New Causes of Hypertriglyceridemia. S.G.Young, A. Beigneux, L. Fong, M. Ploug. UCLA and Finsen Laboratory, Denmark. 11:00 527.3 Novel Mechanisms of Regulation of Bioactive Sphingolipids in Cancer Biology. L.M. Obeid, C. Senkal, M. Pulkoski-Gross. Stony Brook University School of Medicine and Stony Brook University. 11:30 527.4 Geranylgeranyl-Regulated, ER-to-Golgi Transport of UBIAD1: Implications for Cholesterol Homeostasis and Schnyder Corneal Dystrophy. R.A. DeBose-Boyd. UT Southwestern Medical Center.
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528. REDOX SIGNALING AND THE METABOLOME
530. ASBMB MEET THE SPEAKERS
Symposium
Special Event
Wed. 10:00 am—McCormick Place Convention Center, W186ABC
Wed. 1:30 pm—McCormick Place Convention Center, Skyline Ballroom
Chaired: R. Banerjee 10:00 528.1 Mechanism and Control in Radical SAM Enzymes. J.B. Broderick. Montana State University. 10:30 528.2 Biocatalyst Discovery from the Secondary Metabolome. D.H. Sherman, S. Li, A.N. Lowell, S.A. Newmister, F. Yu, R.M. Williams. Life Sciences Institute, University of Michigan, University of Michigan, Life Sciences Institute and Colorado State University. 11:00 528.3 Redox Control of the Metabolome and the Aging Process. V. Gladyshev. Harvard Medical School and Brigham & Women’s Hospital. 11:30 528.4 Signaling Through Hydrogen Sulfide. R. Banerjee. University of Michigan Medical School.
Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • S. Ackerman, UCSD, HHMI • R. Banerjee, Univ. of Michigan Med. Sch. • B. Bukau, Zentrum für Molekulare Biologie der Universität Heidelberg • A. Frost, UCSF • C. Lima, Memorial Sloan Kettering Cancer Ctr. • D. Ron, Univ. of Cambridge
529. ASBMB MEET THE SPEAKERS Special Event Wed. 12:30 pm—McCormick Place Convention Center, Skyline Ballroom Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • A. Amon, MIT, HHMI • R. DeBose-Boyd, UT Southwestern Med. Ctr. at Dallas • A. Dernburg, UC, Berkeley • G. Seydoux, Johns Hopkins Univ. Sch. of Med., HHMI • B. Shoichet, UCSF, Delano Award for Computational Sciences • R. Zechner, Inst. of Molecular Biosciences, Karl Franzens Universität Graz
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• D. Sherman, Univ. of Michigan
WEDNESDAY PATHOLOGY
Pathology 531. LIVER REGENERATIVE MEDICINE Minisymposium Wed. 8:30 am—McCormick Place Convention Center, W181B Chaired: G. Alpini and J. Sanders Liver Pathobiology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) 8:30 531.1 Modeling Cellular Network Dynamics of Liver Homeostatic Renewal. R. Vadigepalli, D. Cook, B. Ogunnaike. Thomas Jefferson University and University of Delaware. 8:45 531.2 Role of Hepatic O-GlcNAcylation on Acetaminophen-Induced Liver Injury. S. McGreal, B. Bhushan, C. Walesky, M.R. McGill, J.L. Weemhoff, H.J. Jaeschke, Z. Zhang, E. Tan, C. Slawson, N.E. Zachara. University of Kansas Medical Center and John Hopkins University. 9:00 531.3 Thrombospondin-1 Contributes to Hepatic Pathology and Systemic Complications in the Acetaminophen and Azoxymethane Mouse Models of Acute Liver Failure. M. McMillin, S. Grant, G. Frampton, G. Alpini, S. DeMorrow. Central Texas Veterans Health Care System and Texas A&M University Health Science Center. 9:15 531.4 Role of Hepatocyte Nuclear Factor 4 Alpha (HNF4α) in Hepatocyte Regeneration. I. Huck, U. Apte. University of Kansas Medical Center. 9:30 531.5 Cell-Specific Wnts Regulate Liver Regeneration After Partial Hepatectomy. M. Preziosi, J.o. Yang, H. Okabe, C. Diegel, B. Williams, S. Monga. University of Pittsburgh and Van Andel Institute.
9:45 531.6 Role of MET and EGFR Signaling in Hepatomegaly and Hepatocyte Proliferation Induced by TCPOBOP (1,4-Bis [2-(3,5-Dichloropyridyloxy)] Benzene) in Mice. B. Bhushan, M.M. Haynes, W.M. Mars, A. Orr, W.C. Bowen, S. Paranjpe, G.K. Michalopoulos. School of Medicine and University of Pittsburgh. 10:00 531.7 Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in HepatocyteDriven Liver Regeneration. J.O. Russell, S. Ko, D. Shin, S.P. Monga. University of Pittsburgh. 10:15 531.8 P53 Regulates Progression of Injury and Liver Regeneration After Acetaminophen Overdose. P. Borude, B. Bhushan, H. Chavan, J.L. Weemhoff, H. Jaeschke, P. Krishnamurthy, U. Apte. University of Kansas Medical Center. 10:30 531.9 Beta-Catenin Dependent Wnt Signaling Promotes Hepatocyte-To-Cholangiocyte Transdifferentiation. K. Kosar, K. Nejak-Bowen. University of Pittsburgh School of Medicine. 10:45 531.10 Phenobarbital Induces ATZ Globule Clearance in a Mouse Model of Alpha-1 Antitrypsin Deficiency. A.W. Bell, J. Stoops, M. Oertel, G.K. Michalopoulos. University of Pittsburgh. 11:00 531.11 Proliferation of Transplanted Hepatocytes Drives Efficient Repopulation in Juvenile Host Rat Livers. P. Stock, M. Hempel, M. Hsu, B. Christ. University of Leipzig, Germany. 11:15 531.12 Rat Liver Repopulation by Transplanted Late Gestation Fetal Hepatocytes. J. Sanders, J. Boylan, H. Francois-Vaughan, P.M. Thomas, J. Sikora, N. Abshiru, P. Gruppuso, N. Kelleher. Brown University, Rhode Island Hospital & Alpert Medical School of Brown University and Feinberg School of Medicine Northwestern University.
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Pharmacology 532. NORMAN WEINER LECTURE Lecture
534. NONPHARMACOLOGICAL FACTORS INFLUENCING DRUG ACTION Symposium
Wed. 8:30 am—McCormick Place Convention Center, W470B
(Sponsored by: ASPET Division for Behavioral Pharmacology)
The Norman Weiner Lecture was established in memory of Dr. Norman Weiner, past ASPET President and chair of the Department of Pharmacology at the University of Colorado. It is in honor of his many contributions to both ASPET and to pharmacology research and education.
Wed. 9:30 am—McCormick Place Convention Center, W471A Chaired: M.A. Nader Behavioral Pharmacology
This lecture runs from 8:30 am–9:20 am. 8:30 Introduction. David Sibley. ASPET. 8:35 Drug Discrimination Procedures and in vivo Pharmacological Analysis. Jack Bergman. Harvard Medical School/McLean Hospital.
533. CHEMICAL BIOLOGY AND DRUG DISCOVERY IN EPIGENETICS Symposium (Sponsored by: ASPET Division for Molecular Pharmacology) Wed. 9:30 am—McCormick Place Convention Center, W470A Chaired: D. Wang and C. He Molecular Pharmacology Cancer Biology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials)
Neuropharmacology Pharmacology Education This session runs from 9:30 am–12:00 pm. 9:30
Influence of Feeding Conditions on the Behavioral Effects of Drugs. Charles France. Univ. of Texas Health Science Center at San Antonio. 10:00 Effects of High Fat Diet and Feeding Pattern on Dopamine Responses to Stimulants. Steven Fordahl. University of North Carolina at Greensboro. 10:30 Nonpharmacological Variables in Drug SelfAdministration. Mark Smith. Davidson College. 11:00 The Influence of Social Variables on the Behavioral Effects of Drugs in Male and Female Monkeys. Michael Nader. Wake Forest School of Med. 11:30 Implementation of Integrated Therapies for Comorbid Post-traumatic Stress Disorder and Substance Abuse. Therese Killeen. Medical University of South Carolina.
535. RELEASE AND PROCESSING OF EXTRACELLULAR ATP: NEW INSIGHTS AND THERAPEUTIC TARGETS Symposium
This session runs from 9:30 am–12:00 pm. 9:30 Introduction. 9:35 Chemical Biology of Protein Post-translational Modification and Regulation. Philip Cole. Johns Hopkins Univ. 10:00 Probing the Epigenome for Therapeutic Targets. Cheryl Arrowsmith. Univ. of Toronto. 10:25 RNA Methylation in Human Diseases. Chuan He. University of Chicago. 10:50 Chemical Biology of Chromatin Regulation and Drug Discovery. Stephen Frye. University of North Carolina—Chapel Hill. 11:15 Functional Interplay between DNA Demethylation and Transcription. Dong Wang. Univ. of California, San Diego. 11:40 Identification of Epigenetic Targets in the Treatment of Recurrent Breast Cancer. N.W. Mabe. Duke University. (823.9) 11:55 Wrap Up.
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(Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Wed. 9:30 am—McCormick Place Convention Center, W474A Chaired: R. Corriden and A.S. MacLeod Translational and Clinical Pharmacology Molecular Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. 9:30
The Pannexin1-alpha Adrenergic Axis Can Mediate Vasoconstriction and Blood Pressure. Brant Isakson. Univ. of Virginia. 10:00 Pannexin1 Channels as Novel Regulators of Cellular Differentiation and Cancer. Silvia Penuela. Western Univ. 10:30 Regulation of CNS Inflammation. Francisco Quintana. Brigham and Women’s Hosp.
WEDNESDAY PHARMACOLOGY 11:00
Sensation of Ultraviolet Radiation-induced Injury and Contribution to DNA Repair by Skin-resident T Cells: The Role of Extracellular ATP and CD39. Amanda MacLeod. Duke University. 11:30 ATP Exposure Increases Expression of α-Synuclein in Sh-Sy5y Cells: Potential Link Between Neuronal Injury and Parkinson’s Disease. J.T. Lamberts, D. Rustem, B. Wallis, C. Zwart. Ferris State University. (814.11) 11:45 Pannexin-1 Channel Activity and Associated ATP Release in Podocytes in Response to Adipokines. G. Li, Q. Zhang, N. Li, J.K. Ritter, P. Li. Virginia Commonwealth University. (991.9)
536. INTESTINE-LIVER CROSSTALK, NEW FRONTIER FOR DRUG METABOLISM, LIVER INJURY AND REPAIR Symposium (Sponsored by: ASPET Division for Toxicology) Wed. 9:30 am—McCormick Place Convention Center, W474B Chaired: G.L. Guo and L.M. Aleksunes Toxicology Inflammation/Immunity Microbiome This session runs from 9:30 am–12:00 pm. 9:30 Introduction. 9:40 Intestine Bile Acid Induced Endocrine Signal in Liver Injury and Repair. Grace Guo. Rutgers Univ.—Ernest Mario Sch. of Pharmacology. 10:05 FXR-FGF15/19 Signaling and Bile Acid Homeostasis During Pregnancy. Lauren Aleksunes. Rutgers Univ. 10:30 Gut Microbiome Regulation of Drug Metabolism and Xenobiotic Exposure. Yue (Julia) Cui. Univ. of Washington. 10:55 The Gut-liver Axis in Eythropoietic Protoprophyria. Xiaochao Ma. Univ. of Pittsburgh. 11:20 Antagonizing Intestinal FXR in Liver Lipid Metabolism Regulation. Frank Gonzalez. NIH. 11:45 Fibroblast Growth Factor 21 Depletion Attenuates Acute Experimental Colitis in Mice Through Epithelial STAT3 Activation. W. Feng, G. Dryden, C. McClain. University of Louisville and Robley Rex VAMC. (995.1) 11:55 Wrap Up.
537. THE PHARMACOLOGICAL AND THERAPEUTIC LEGACY OF DR. ALFRED G. GILMAN Symposium (Sponsored by: ASPET Division for Molecular Pharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W470A Chaired: M.L. Toews and P.C. Sternweis Molecular Pharmacology Cancer Biology Inflammation/Immunity Dr. Alfred G. Gilman was a major contributor to multiple aspects of pharmacology through both his Nobel Prize-winning research on G proteins and adenylyl cyclases and his many years of personally editing Goodman and Gilman’s The Pharmacological Basis of Therapeutics textbook. This symposium will honor his legacy with presentations by a few of his many successful trainees. This session runs from 3:00 pm–5:30 pm. 3:00
Opening Comments. Paul Sternweis. Univ. Texas Southwestern Health Science Center, Pharmacology. 3:10 The Allosteric Interaction Between GPCRs, G Proteins, Small Molecules and Cations. Roger Sunahara. Univ. of California, San Diego. 3:35 G Protein GAPs. Elliott Ross. Univ. of Texas Southwestern Medical Center. 4:00 Break. 4:05 Involement of G12 Proteins in Oncogenesis and Tumor Progression. Patrick Casey. Duke-NUS Medical School, Singapore. 4:30 Spatial Constraints of G protein Regulation of Adenylyl Cyclase. Carmen Dessauer. Univ. of Texas Health Science Center at Houston. 4:55 Crystal Structure Analysis of G Proteins and Adenylyl Cyclases. Stephen Sprang. Univ. of Montana. 5:20 Wrap Up.
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538. DEVELOPING NOVEL THERAPEUTIC STRATEGIES TO MODULATE K+/CL- COTRANSPORTER 2 (KCC2) FUNCTION
3:35 4:05
Symposium (Sponsored by: ASPET Division for Neuropharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W470B Chaired: P.A. Davies and T.G. Deeb
4:35 5:05
Neuropharmacology Drug Discovery and Development Neurobiology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 A New Role for Erythropoietin (EPO) in Neurorepair: Attenuating KCC2 Loss in the Preterm Brain. Lauren Jantzie. Univ. of New Mexico. 3:30 Small Molecule TrkB Antagonist, ANA-12 Rescues Ischemia Induced KCC2 Degradation and Phenobarbital-resistant Neonatal Seizures in a Dose Dependent Manner. Shilpa Kadam. Kennedy Krieger Inst. and Johns Hopkins Univ. Sch. of Med. 3:55 Mulitprotein Complexes Regulating Excitatory and Inhibitory Neurotransmission in the Brain. Vivek Mahadevan. NIH, McBain Lab (visiting fellow) 4:10 Stretch Break. 4:15 Assessing the Impact of Enhanced KCC2 Function on Seizure Severity. Yvonne Moore. Tufts University School of Medicine. 4:30 KCC2 Pharmacology and Function during Hyperexcited States. Tarek Deeb. Tufts Univ. School of Medicine. 4:55 Restoration of KCC2 Expression Rescues Functional Deficits in Human Neurons Derived from Patients with Rett Syndrome. Xin Tang. Whitehead Institute for Biomedical Research. 5:20 Wrap Up.
539. TRANSPORTER ROLES IN INTRACELLULAR DRUG CONCENTRATIONS Symposium (Sponsored by: ASPET Division for Drug Metabolism) Wed. 3:00 pm—McCormick Place Convention Center, W471A Chaired: Y. Lai and I. Tamai Drug Metabolism Transporters/Channels/Barriers This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Local Transporter Drug—Drug Interaction of Donepezil with Cilostazol Increases Drug Accumulation in Heart. Ikumi Tamai. Kanazawa Univ.
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5:18
Apply a PET Approach to Monitor Hepatic Uptake and Excretory Function. Yuichi Sugiyama. RIKEN Innovation Center Research Cluster for Innovation. The Combination of in vitro Experimental and Modelling Approaches to Predict in vivo Intracellular Partitioning. Yurong Lai. Bristol-Myers Squibb. PBPK Modeling to Estimate the Effects of Renal Impairment and Transporter Inhibition on Drug Exposure in the Kidneys. Ping Zhao. Live Tissue Imaging of Organic Cation and Anion Transport at the Blood-CSF Barrier Reveals Specific Transporter Function and Distinct Transcellular Pathways. T. Hu, W. Zha, H. Duan, J. Wang. University of Washington. (1062.14) Alcohol Induced Changes in Cellular Pharmacokinetics and Pharmacodynamics of Elvitegravir and Darunavir in HIV-1 Infected Monocytic Cells. N.M. Midde, N. Sinha, Y. Gong, B. Meibohm, S. Kumar. University of Tennessee Health Science Center. (822.3)
540. STEM CELLS IN CANCER Symposium (Sponsored by: ASPET Division for Cancer Pharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W474A Chaired: R.K. Guy and S. McKinney-Freeman Cancer Pharmacology Cancer Biology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) This session runs from 3:00 pm–5:30 pm. 3:00 Overview. Shannon McKinney-Freeman. St Jude Children’s Research Hospital. 3:10 Stem Cells in Leukemia. Guy Sauvageau. Univ. of Montreal. 3:40 A Chemical Approach to Controlling Cell Fate. Sheng Ding. Gladstone Institute of Cardiovascular Disease. 4:10 Enhancing Mammalian Regeneration: Mechanisms and Consequences. Hao Zhu. UT Southwestern Medical Center. 4:40 New Targeted Approaches for Pediatric Malignancies. Kimberly Stegmaier. Dana-Farber Cancer Institute. 5:10 Repairing Interstrand DNA Crosslinks (ICL): Characterization of an ICL Incision/Lesion Bypass Polymerase Complex Regulated by the Fanconi Anemia Pathway. V.P. Jasti, S. Sharma, I. Althaus, A. Weinstein, S. Ramani, C. Canman. University of Michigan. (996.3) 5:25 Wrap Up. R. Guy. Univ. of Kentucky Sch. of Pharmacy.
WEDNESDAY PHARMACOLOGY
541. EPIGENETIC REGULATION OF TOXICITY AND IMPLICATIONS FOR RISK ASSESSMENT
4:00 4:30
Symposium (Sponsored by: ASPET Division for Toxicology) Wed. 3:00 pm—McCormick Place Convention Center, W474B
5:00
Chaired: B.S. Cummings and D.C. Dolinoy Toxicology Translational and Clinical Pharmacology Cancer Biology
5:15
Epigenetic Targets of Toxicity and Drivers of Disease. Cheryl Walker. Baylor College of Medicine. Predicting Inter-Individual Variability in Post-Exposure Response: The “Epigenetic Seed and Soil” Model of Susceptibility. Shaun McCullough. U.S. Environmental Protection Agency. Epigenetic Modifications Influence NOD-Like Receptor Expression and Associated Pro-Inflammatory Activity. C. Feerick, D.P. McKernan. NUI Galway, Ireland. (1060.2) Image-Based Screening for Epigenetic Modifiers of Myofibroblast Activation. A.J. Haak, G. Ligresti, R. Abbey, S. Romanov, T.D. Chung, D.J. Tschumperlin Mayo Clinic and Nanosyn Inc. (1060.3)
This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Perinatal Lead (Pb) Exposure and Effects on Offspring DNA Methylation in Mouse and Human Cohorts. Dana Dolinoy. Univ. of Michigan School of Public Health. 3:35 Role of Epigenetics in the Molecualr Mechanisms of Action of Renal Cell Death Induced by the Water Disinfection Byproduct Bromate. Brian Cummings. Univ. of Georgia-Athens College of Pharmacy.
542. ASPET CLOSING RECEPTION Special Event Wed. 6:00 pm —McCormick Place Convention Center, Skyline Ballroom Pre-Function Area We invite ASPET members and pharmacology attendees to join us for a closing reception.
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PHYSIOLOGY WEDNESDAY
Physiology 543. APS PRESIDENT’S SYMPOSIUM SERIES: RESEARCH ADVANCES IN SEX/GENDER AND DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES APS NOBEL PRIZE AWARD LECTURE Lecture Wed. 4:45 pm—McCormick Place Convention Center, W375A
4:45
9:00 9:30
546. ORGANELLE DYSFUNCTION IN PULMONARY VASCULAR DISEASE: MITOCHONDRIA, ENDOPLASMIC RETICULUM, LYSOSOMES AND BEYOND
Sex Differences and Women’s Health
Featured Topic
Hypertension
(Sponsored by: Respiration Section) Wed. 8:00 am—McCormick Place Convention Center, W196C
The Road to Stockholm: A Nobel Mission. Louis Ignarro. UCLA Sch. of Med.
Chaired: L. Shimoda and J.R. Sheak
544. THE MODULATION OF AGING THROUGH ALTERED PROTEOSTASIS
Energy Homeostasis Injury Repair and Regeneration
Symposium (Cosponsored by: The Physiological Society and Journal of Physiology) Wed. 8:00 am—McCormick Place Convention Center, W196B Chaired: B. Miller 8:00
ER Proteostasis and Aging: Insights from Long-Lived Mutant Mice. Colin Selman. Univ. of Glasgow. 8:30 Evidence for Mitochondrial Proteostasis as a Shared Characteristic of Slowed Aging. Karyn Hamilton. Colorado State Univ. 9:00 Role of Nerve-Muscle Interactions and ROS in Regulation of Muscle Proteostasis with Aging. Aphrodite Vasilaki. Univ. of Liverpool. 9:30 Mitophagy’s Role in Maintaining Mitochondrial Proteostasis and Metabolic Health. Josh Drake. Univ. of Virginia.
545. ENVIRONMENTAL, MICROENVIRONMENTAL AND NANOENVIRONMENTAL FACTORS WHICH DRIVE LIVER DISEASE PATHOGENESIS AND PROGRESSION Symposium (Cosponsored by: GI and Liver Physiology Section and AJP–Gastrointestinal and Liver Physiology) Wed. 8:00 am—McCormick Place Convention Center, W194B Chaired: M.T. Pritchard Genetics, Epigenetics, MicroRNA 8:00 8:30
176
Adenosine-Mediated Regulation of Liver Tissue Repair and Regeneration. Michel Fausther. University of Arkansas for Medical Sciences. Role of miRNA17-92 in Liver Injury. Laura Schrum. Carolinas HealthCare System Cannon Research Center.
Circadian Alterations in Alcoholic Liver Disease. Shannon Bailey. University of Alabama at Birmingham. Role of the Hemostatic System in Experimental Liver Fibrosis. James Luyendyk. Michigan State University.
Inflammation/Immunity 8:00
Targeting the Mitochondria in Pulmonary Hypertension. Evangelos Michelakis. University of Alberta. 8:30 PKCβ Signals Through Mitochondrial Reactive Oxygen Species Production in Pulmonary Arterial Smooth Muscle Cells of Neonatal Rats. J.R. Sheak, N.L. Jernigan, B.R. Walker, T.C. Resta. University of New Mexico. (1073.7) 8:45 Mitochondrial Hsp90 exerts pro-survival functions in Pulmonary Arterial Hypertension. O. Boucherat, S. Breuils-Bonnet, S. Chabot, J. Meloche, G. Vitry, C. Lambert, V. Nadeau, E. Tremblay, G. Sutendra, E. Michelakis,Y. Chae, D. Altieri, R. Paulin, S. Provencher, S. Bonnet. IUCPQ Research Centre, Canada, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada, Laval University, Canada, University of Alberta, Canada, and The Wistar Institute. (1073.10) 9:00 Apoptosis in Pulmonary Hypertension Is Regulated by the Sodium-Hydrogen Exchanger. J. Huetsch, X. Yun, K. Suresh, H. Jiang, L. Shimoda. Johns Hopkins SOM. (1073.3) 9:15 TNFα Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells. J.Q. Yap, P. Delmotte, G.C. Sieck. Johns Hopkins University and Mayo Clinic. (726.4) 9:30 Sodium-Coupled Neutral Amino Acid Transporter SNAT2 Counteracts Edema Formation and Reduces Autophagy and Er Stress in Acute Lung Injury. S. Weidenfeld, C.J. Chupin, S. Rozowsky, W.M. Kuebler. Keenan Research Centre for Biomedical Science, St. Michael´s Hospital, Canada, Charité-Berlin, Germany and University of Toronto, Canada. (725.4) 9:45 Conditioned Media from Keratinocyte Growth Factor Modified Mesenchymal Stromal Cells Reduces Pulmonary Vascular Permeability. S. Pati, R. Croze, S. Gibb, D. Potter, X. Fang, M.A. Matthay. Blood Systems Research Institute, University of California at San Francisco. (1073.9)
WEDNESDAY PHYSIOLOGY
547. GLIAL CELL DEVELOPMENT, MIGRATION, AND PATHOPHYSIOLOGY
8:22
Symposium (Sponsored by: Cell and Molecular Physiology Section) Wed. 8:00 am—McCormick Place Convention Center, W192B
8:37
Chaired: K. Gagnon and H. Sontheimer Neurophysiology
8:52
Neurobiology 8:00 8:30
Inhibiting Glial Tumor Release of Glutamate Prevents Brain Tumor Malignancy. Harald Sontheimer. Virginia Tech. Glial Migration across Transition Zones. Sarah Kucenas. University of Virginia. Genetic Analysis of Glial Development and Function in Zebrafish. William Talbot. Stanford University. Micro-environmental Regulation of Glial Cells in Spinal Cord Injury. Sohelia Karima. University of Manitoba Max Rady College of Medicine.
9:00 9:30
548. NON-MOTOR DYSFUNCTIONS IN PARKINSON’S DISEASE Symposium (Sponsored by: CNS Section) Wed. 8:00 am—McCormick Place Convention Center, W193
9:07
9:22 9:52
550. MECHANISMS PRESERVING BREATHING STABILITY Symposium
Chaired: R.A. Travagli 8:00 8:40 9:20
Chaired: J. Watters and K. Braegelmann Neurophysiology Physiology of Extreme Environments Neurobiology 8:00 8:30
(Sponsored by: Environmental and Exercise Physiology Section)
9:00
Chaired: C. Minson and S.A. Romero Physiology of Extreme Environments
8:07
Wed. 8:00 am—McCormick Place Convention Center, W190B
Featured Topic
Wed. 8:00 am—McCormick Place Convention Center, W192A
8:00
(Sponsored by: Respiration Section)
Modeling Non-Motor Aspects of Parkinson’s Disease in Alpha-Synuclein Overexpressing Mice. MarieFrancoise Chesselet. UCLA. Gastrointestinal Dysfunctions in Parkinsons Disease. R Travagli. Penn State College of Medicine. The Heart of Parkinson’s Disease: Neurocardiologic Abnormalities and Their Relationships with Other Non-Motor Aspects. David Goldstein. NINDS, NIH.
549. EXPLOITING ENVIRONMENTAL STRESSORS TO IMPROVE HEALTH AND PERFORMANCE
Combined Effects of Remote Ischemic Preconditioning and Aerobic Exercise on Sympathetic and Cerebrovascular Responses: A Novel Adaptation of Blood Flow Restriction Exercise. J. Sprick, H. Colby, C.A. Rickards. University of North Texas Health Science Center. (1086.1) Alterations of Mitochondrial Function and Metabolism in Skeletal Muscle, Liver, and White Adipose: Early Evidence for the Lactation Reset Hypothesis. H.W. Hyatt, Y. Zhang, W.R. Hood, A.N. Kavazis. Auburn University. (1086.7) Effects of Gravity and Lower Body Negative Pressure on Intracranial Pressure: Implications for Astronauts and Patients on Earth. L.G. Petersen, A. Hargens, J. Petersen, A. Cyron, M. Juhler. University of Copenhagen, Denmark, University of California, San Diego, Rigshospitalet and University of Copenhagen, Denmark. (1086.3) Mild Heat Pretreatment and Serum from Sedentary Humans Subjected to Passive Heat Therapy Protect Endothelial Cells Against Stress from HypoxiaReoxygenation. V.E. Brunt, K.W. Needham, L.N. Comrada, C.T. Minson. University of Oregon and University of Colorado Boulder. (1086.2) Game Changing Applications of Hypoxia: Beyond Altitude Training. Benjamin Levine. UT Southwestern Medical Center. Closing Remarks. Christopher Minson. Univ. of Oregon.
9:30
Coordination of Breathing and Swallowing. Emily Plowman. University of Florida. Fatal Instabilities in Cardio-Respiratory Control during a Critical Period of Development. Peter MacFarlane. Case Western Reserve University. Ventilatory Pattern Variability Following Acute Lung Injury: Insights into Central Mechanisms. Frank Jacono. Case Western Reserve University. Inactivity-Induced Phrenic Motor Facilitation Stabilizes Breathing in Rats. Tracy Baker. University of Wisconsin-Madison.
Opening Remarks. Steven Romero. Univ. of Texas Southwestern Med. Ctr. Heat Therapy Alters the Expression of Myogenic and Angiogenic Factors and Accelerates Functional Recovery Following Exercise-Induced Muscle Damage in Humans. K. Kim, Y. Nie, D. Boersma, Q. Song, S. Kuang, T. Gavin, B. Roseguini. Purdue University. (1086.4)
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PHYSIOLOGY WEDNESDAY
551. SATELLITE CELLS: EXTERNAL AND SYSTEMIC INFLUENCES
9:45
Featured Topic (Sponsored by: Muscle Biology Group) Wed. 8:00 am—McCormick Place Convention Center, W196A
553. CENTRAL AND PERIPHERAL MECHANISMS REGULATING BODY WEIGHT AND GLUCOSE HOMEOSTASIS
Chaired: N. Brooks and E. Dupont-Versteegden
Featured Topic
Muscle Metabolism 8:00 Introduction. Esther Dupont-Versteegden. Univ. of Kentucky. 8:20 The Regulation of Muscle Satellite Cells during Stress and Aging. Andrew Brack. University of California, San Francisco. 9:00 Satellite Cell Activation by Voluntary Wheel Running Is Associated with Improved Recovery from Muscle Disuse in Mice. M.J. Brooks, J.S. Mohamed, S.E. Alway. West Virginia University School of Medicine. (1082.9) 9:15 The Impact of Disuse Muscle Atrophy on Perivascular Stem Cell Quantity and Function. M.R. Munroe, M.C. Dyle, C.M. Adams, M.D. Boppart. University of Illinois at Urbana-Champaign and University of Iowa. (1082.8) 9:30 Implantable Biomimetic Niche for Satellite Cell Transplantation. Y.C. Jang, W. Han, E. Shin, A. Garcia. Georgia Institute of Technology. (1082.1) 9:45 PYY Regulates Human Skeletal Muscle Progenitor Cell Proliferation. B.J. Gheller, H.A. Roman, A.E. Thalacker-Mercer. Cornell University. (1082.7)
552. MITOCHONDRIAL PHYSIOLOGY IN CARDIOVASCULAR DISEASE Featured Topic (Sponsored by: Cardiovascular Section)
(Sponsored by: Endocrinology and Metabolism Section) Wed. 8:00 am—McCormick Place Convention Center, W192C Chaired: A. Zsombok Energy Homeostasis 8:00 8:30 9:00
9:15 9:30
9:45
Wed. 8:00 am—McCormick Place Convention Center, W190A Chaired: J. Calvert and J. Elrod 8:00
Mitochondrial Calcium Exchange in Cardiac Physiology and Disease. Jonathan Lederer. University of Maryland. 8:45 Malignant Hyperthermia-Associated Mutation of RyR1 Induces mitochondrial Ca2+ Overload in the Cardiomyocytes. J. O-Uchi, J. Mishra, B. Jhun, S. Sheu. Rhode Island Hospital, Brown University and Thomas Jefferson University. (1080.5) 9:00 Myocardin Regulates Mitochondrial Calcium Homeostasis and Prevents Permeability Transition in Cardiac Myocytes. J. Gordon, W. Mughal, J. Field, Y. Hai, D. Chapman, R. Keijzer, S. Rattan, I. Dixon, J. Huang, M. Parmacek. University of Manitoba, Canada and University of Pennsylvania. (1080.6) 9:15 Mitochondria-Derived Small Non-Coding RNAs in Extreme Anoxia Tolerance. C.L. Riggs, J.E. Podrabsky. Portland State University. (1080.2) 9:30 Gcn5l1 Promotes Enhanced Cardiac Fatty Acid Oxidation Through Acetylation of Mitochondrial Proteins. D. Thapa, M. Zhang, D.A. Guimarães, M.W. Stoner, R.M. O’Doherty, S. Shiva, I. Scott. University of Pittsburgh. (1080.3)
178
The Role of Autophagy in Aged Cardiomyocyte Arrhythmogenesis. K.R. Murphy, Y. Lu, J. O-Uchi, D. Terentyev, G. Koren. Brown University and Lifespan. (1080.4)
Developmental Actions of Leptin on CNS Pathways Involved in Body Weight and Glucose Regulation. Sebastien Bouret. University of Southern California. The Role of Central Lipid Sensing in the Regulation of Hepatic Metabolism. Kimberley Bruce. University of Colorado School of Medicine. Hepatic Sympathetic Denervation Reduces NonAlcoholic Fatty Liver Disease in Diet-Induced Obese Mice. C. Hurr, H. Simonyan, C.N. Young. George Washington University and School of Medicine and Health Sciences. (1089.6) Contribution of POMC and AgRP Neurons to the Control of Metabolic Autonomic Nerve Activity by Leptin. B. Bell, D. Morgan, K. Rahmouni. The University of Iowa. (1089.2) Angiotensin-II Type 1a Receptor Present in Insulin Producing cells is Essential for Normal Islet Function. H. Chodavarapu, J. Xu, E. Lazartigues. Louisiana State University Health Sciences Centre. (1089.9) Skeletal Muscle Integrin-Linked Kinase Contributes to Adipose Tissue Fibrosis and Adipogenesis in Diet-Induced Obese Mice. D. Lark, I. Williams, L. Kang, S. Shakir, C. Hughey, R. Zent, A. Pozzi, D. Wasserman. Vanderbilt University and University of Dundee, United Kingdom. (1089.8)
554. THE IMPACT OF EXOSOMES ON MUSCLE ATROPHY, HYPERTROPHY AND MYOGENESIS Symposium (Sponsored by: Integrative Physiology Symposium Series) Wed. 8:00 am—McCormick Place Convention Center, W375A Chaired: X.H. Wang and W.E. Mitch 8:00
Skeletal Muscle Exosome Responses to Acute and Chronic Exercise. Timothy Gavin. Purdue Univ. 8:30 Perpl-Exosomes: Elucidating the Complexity of Exosomes Released during Muscle Atrophy. Matthew Hudson. Temple Univ. 9:00 Satellite Cell-Derived Exosomes Regulate Skeletal Muscle Extracellular Matrix Remodeling during Muscle Hypertrophy. Christopher Fry. Univ. of Texas Med. Branch. 9:30 Muscle-Kidney Crosstalk through Exosome. Xiaonan Wang. Emory Univ.
WEDNESDAY PHYSIOLOGY
555. NEURAL CONTROL OF THE HEART: NEW TOOLS, NEW MECHANISMS Featured Topic
10:30
556. SEXUAL DIMORPHISM, PLASTICITY AND GENOMIC DIVERSITY OF THE PARAVENTRICULAR NUCLEUS
(Sponsored by: Neural Control and Autonomic Regulation Section)
Symposium
Wed. 10:30 am—McCormick Place Convention Center, W193
Experimental Physiology
(Sponsored by: The Physiological Society—UK)
Chaired: M. Chapleau and R.A. Larson
Wed. 10:30 am—McCormick Place Convention Center, W196A
Neurophysiology
Chaired: G.L. Yosten and W.K. Samson
Neurobiology
Sex Differences and Women’s Health
Role of Acid-Sensing Ion Channels in Cardiac Sensory Neurons. Christopher Benson. University of Iowa. 11:00 Potent Blood Pressure Lowering Effect of Optogenetic Stimulation of “Angiotensin-Sensitive” Neurons Within the Nodose Ganglion. G.B. da Silva Souza, E.B. Bruce, H. Hiller, M.D. Smeltzer, Y. Tan, I.V. Brandi, C. Sumners, M.K. Raizada, E.G. Krause, A.D. de Kloet. University of Florida. (1071.1) 11:15 At1 Receptor on Glutamatergic Neurons Regulate Cardiac Function Through Modulation of Excitability and Sympathetic Outflow. J. Xu, A. Molinas, A. Zsombok, E. Lazartigues. LSUHSC-New Orleans and Tulane University School of Medicine. (1071.2) 11:30 Altered Regulation of Cardiac Sympathetic Nerve Activity During Hypertension. R. Ramchandra, F. McBryde, B. George, J.F. Paton, D. Mahesh. The University of Auckland, New Zealand and University of Bristol, United Kingdom. (1071.4) 11:45 Transcriptomic Analysis of the Stellate Ganglion After MI. R. Bayles, A. Olivas, R. Gardner, J. Burchard, B. Habecker. Oregon Health & Science University. (1071.5) 12:00 Reliability of Heart Rate Variability as an Assessment of Cardiac Sympathetic Activity in Humans. T.R. Wakeham, I.T. Fonkoue, J.J. Durocher, W.H. Cooke, J.R. Carter. Michigan Technological University and University of Texas at San Antonio. (1071.6) 12:15 Newborn Body Fatness and Autonomic Function: Identification of Infants at Risk of Later Cardiovascular Disease. H. Dissanayake, R. McMullan, M. Phang, A. Gordon, J. Hyatt, C. Rains-Greenow, D. Celermajer, J. Polson, M. Skilton. Sydney Medical School, University of Sydney, Australia, Boden Institute, Australia, Royal Prince Alfred Hospital, Australia and Bosch Institute, Australia. (1071.8)
10:30 Transcriptomic Responses. Alastair Ferguson. Queens Univ. 11:00 Stress Induced Sexually Dimorphic Plasticity in the Paraventricular Nucleus. Jaideep Bains. Univ. of Calgary. 11:30 Sex Differences in Fluid Balance. Jessica Santollo. Univ. of Kentucky. 12:00 Sex-Dependent Factors Regulating Pressure and Flow. Jill Barnes. Univ. of Wisconsin.
557. COMPARATIVE PERSPECTIVES ON HYPOXIA SIGNALING AND TOLERANCE
W E D
Featured Topic (Sponsored by: Comparative & Evolutionary Physiology Section) Wed. 10:30 am—McCormick Place Convention Center, W190B Chaired: G.R. Scott Physiology of Extreme Environments Oxygen Transport 10:30 Human and Animal Adaptation to Hypoxia: Lessons from High Altitude. Gabriel Haddad. University of California San Diego. 11:00 High-Altitude Adaptation and Hypoxia Signaling in Deer Mice. G.R. Scott, C.M. Ivy, K.B. Tate, J.P. Velotta, R.M. Schweizer, Z.A. Cheviron. McMaster University, Canada, Truman State University and University of Montana. (1075.2)
179
PHYSIOLOGY WEDNESDAY 11:15 HIF-1 Plays a Key Signaling Role in Physiological Responses to Acute Hypoxia in the African Naked Mole Rat, Heterocephalus glaber. M.E. Pamenter. University of Ottawa, Canada and University of Ottawa Brain and Mind Research Institute, Canada. (1075.3) 11:30 Reactive Oxygen Species Signaling in the HypoxiaTolerant Turtle and Goldfish Stellate and Pyramidal Neurons Is Species Specific. L. Buck, N. HossienJavaheri, V. Pillai, P. Hawrysh. University of Toronto, Cell and Systems Biology, Canada and University of Toronto, Canada. (1075.5) 11:45 Comparative Physiology of Hypoxia Tolerance in Intertidal Sculpins. J. Richards, G. Lau. The University of British Columbia, Canada. (1075.7) 12:00 A Paradigm Shift: Benefits of Carbon Monoxide (CO) in Hypoxia-Adapted Species. M.S. Tift, P. Jordan, T. Lueker, P. Cabrales, T. Simonson, E. Heinrich, F. Villafuerte, J. Meir, D.E. Crocker, B. Moore, J. St. Leger, P.J. Ponganis. Scripps Institution of Oceanography, University of California, San Diego, Universidad Peruana Cayetano Heredia, NASA, Sonoma State University and SeaWorld. (719.16) 12:15 From Field to Lab: Asking Questions About Hypoxia Regulation of Vascular Tone in Cell Culture Systems. A. Hindle, K. Allen, A. Batten, L. Wareham, E. Buys, W. Zapol. Massachusetts General Hospital and Colorado State University. (1075.1)
558. KICK START YOUR FUNDING: LOOKING BEYOND NIH AND NSF Symposium
Symposium (Sponsored by: Translational Physiology Interest Group) Wed. 10:30 am—McCormick Place Convention Center, W192A Chaired: L.E. de Castro Brás and G.V. Halade Injury Repair and Regeneration 10:30
Small Molecules and Their Signaling Mechanisms on Heart Failure. Burns Blaxall. Cincinnati Children’s Hospital Medical Center. 11:00 Defining the Roles of Molecular Resolving and NonResolving Mediators in Heart Failure Pathology. Vasundhara Kain. The University of Alabama at Birmingham. 11:30 ECM-Generated Peptides Function in Post-MI Remodeling. Merry Lindsey. University of Mississippi Medical Center. 12:00 Mitochondria-Targeting Peptides in Heart Disease. David Brown. Virginia Tech.
560. BLOOD DOPING: PHYSIOLOGY, PHARMACOLOGY AND DETECTION CHALLENGES Symposium (Cosponsored by: Environmental and Exercise Physiology Section and Journal of Applied Physiology)
(Sponsored by: Trainee Advisory Committee)
Wed. 10:30 am—McCormick Place Convention Center, W196C
Wed. 10:30 am—McCormick Place Convention Center, W192C
Chaired: L. Bowers
Chaired: J. Steiner and K. Streeter
Oxygen Transport
10:30 Seeking Funding Outside the Norm: Unique Opportunities within Military Research Programs. Lisa Leon. Thermal Mountain Medicine Division. 11:00 Successfully Securing Funding and Collaborating with industry. Wai Man (Eugene) Shek. Lilly China Research and Development Co., Ltd. 11:30 Cancer Funding from a Private Foundation. Charles Saxe. The American Cancer Society. 12:00 Crowd Funding Your Science. Melissa Wilson Sayres. Arizona State Univ.
180
559. PEPTIDES AND METABOLITES IN CARDIOVASCULAR DISEASE
10:30 Current Status of Hematological Manipulation and Detection in Sport. Larry Bowers. US AntiDoping Agency. 10:50 Physiology of Blood Doping and Challenges. Yorck Schumacher. Aspetar Orthopaedic and Sports Medicine Hospital. 11:10 Pharmacology of Erythropoiesis Stimulating Agents. Steve Elliott. Newbury Park, CA. 11:30 Athlete Biological Passport, Detection Methods and Complementary Biomarkers. Daniel Eichner. Sports Medicine Research Testing Laboratory. 11:50 Red Blood Cell Population Dynamics and Individualized Modeling. John Higgins. Massachusetts General Hospital.
WEDNESDAY PHYSIOLOGY
561. NEW INSIGHTS INTO THE REGULATION OF RENAL BLOOD FLOW IN HEALTH AND DISEASE Symposium (Sponsored by: Renal Section) Wed. 10:30 am—McCormick Place Convention Center, W194B Chaired: A. Polichnowski and J. Williams Microbiome Hypertension Salt 10:30
The Physiological Significance of TGF Response in the Long-Term Control of Sodium Excretion and Blood Pressure. Ruisheng Liu. University of South Florida. 11:00 ROS Differentially Regulate Myogenic Tone. Chris Wilcox. Georgetown University Medical Center. 11:30 The Role of NADPH Oxidase Subunit p67phox in the Regulation of Renal Function in Dahl S Rats. Louise Evans. Medical College of Wisconsin. 12:00 Renal Autoregulation and Dynamics of Glomerular BP Transmission in Conscious Rats: Novel Analysis Methods and Insights. Karen Griffin. Loyola University.
562. INFLAMMATION AND IMMUNITY AND HEART DISEASE Featured Topic
11:30
Efficacy of Tolerizing Vaccination Strategy for Mitigating Autoimmune-Mediated Cardiac Injury. R.M. Lust, S.P. Reece, M.R. Van Scott, M.D. Mannie. East Carolina University and Brody School of Medicine. (1079.2) 11:45 Administration of Anti-Inflammatory Interleukin-37 Ameliorates Age-Related Vascular, Metabolic and Physical Dysfunction in Mice. Z.J. Sapinsley, D.B. Ballak, V.E. Brunt, M.C. Zigler, R.A. Gioscia-Ryan, J.J. Richey, C.A. Dinarello, D.R. Seals. University of Colorado Boulder, University of Colorado Denver and Radboud University Medical Center, Netherlands. (1079.3) 12:00 CXCL4 Aggravates Cardiac Dilation and Mortality After Myocardial Infarction by Inducing ProInflammatory M1 Macrophages and Inhibiting Macrophage Phagocytosis. M.L. Lindsey, M. Jung, A. Yabluchanskiy, P.L. Cannon-Stewart, R.P. Iyer, E.R. Flynn, K.Y. DeLeon-Pennell, Y. Ma. University of Mississippi Medical Center. (1079.4) 12:15 Inhibition of Allograft Inflammatory Factor-1 Attenuates B Cell Development and Infiltration to Cardiac Tissue During the Development of Diabetic Cardiomyopathy. A. Sarkar, S.K. Shukla, K. Sikder, A.Y. Tsygankov, K. Rafiq. Thomas Jefferson University and Temple University. (1079.5)
563. MIRNA REGULATION OF THE MITOCHONDRION IN CARDIOVASCULAR DISEASE Symposium
(Sponsored by: Cardiovascular Section)
(Cosponsored by: Cardiovascular Section and AJP–Heart and Circulatory Physiology)
Wed. 10:30 am—McCormick Place Convention Center, W190A
Wed. 10:30 am—McCormick Place Convention Center, W196B
Chaired: G. Halade and E. Thorp
Chaired: J. Hollander and D. Thapa
Inflammation/Immunity
Genetics, Epigenetics, MicroRNA
10:30 Cardiac Macrophages in Steady-State and Disease. Matthias Nahrendorf. Harvard Medical School. 10:50 Myeloid Cells and Cardiac Repair. Jean-Sebastien Silvestre. INSERM UMRS 970 11:15 Identification of Inflammatory Biomarkers for Hypertension From Isolated Human Monocytes. A.E. Norlander, C.L. Galindo, F. Elijovich, C.L. Laffer, K.R. Montaniel, J.S. Gnecco, M.S. Madhur. Vanderbilt University. (1079.1)
10:30 MiRNA Regulation of the Mitochondrial Genome: Impact of Diabetes Mellitus. John Hollander. West Virginia University. 11:00 MitomiRs: a New Player in Cardiovascular Health. Samarjit Das. Johns Hopkins University. 11:30 MiRNAs in Ischemic Injury: A Role for Mitophagy. Roberta Gottlieb. Cedars-Sinai Hospital. 12:00 Impact of Anti-miR Strategies on Macrophage Mitochondria and the Development of Atherosclerosis. Katy Rayner. University of Ottawa.
181
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PHYSIOLOGY WEDNESDAY
564. CARDIOVASCULAR CONTROL AFTER NEUROLOGICAL INJURY
565. MECHANISMS OF HYPERTENSION RISK Symposium
Featured Topic
(Sponsored by: Water and Electrolyte Homeostasis Section)
(Supported by Vancouver Coastal Health Res. Inst.)
Wed. 2:30 pm—McCormick Place Convention Center, W196B
(Sponsored by: Cardiovascular Section) Wed. 10:30 am—McCormick Place Convention Center, W192B Chaired: A.A. Phillips and C.R. West
2:30
Neurophysiology
3:00
Neurobiology 10:30 Cardiovascular Control after Spinal Cord Injury. Andrei Krassioukov. International Collaboration on Repair Discoveries. 11:00 Heart Rate and Blood Pressure Responses to Head-Up Tilt Following Autonomic Blockade in Persons with SCI and Intact Controls. J.M. Wecht, J.P. Weir, N. Nhuquynh, G.J. Schilero, W.A. Bauman. James J Peters VA Medical Center, Icahn School of Medicine, Mount Sinai and University of Kansas. (1077.8) 11:15 Left Ventricular Contractile Function Is Critically Dependent on Descending Sympathetic Control and Can Be Restored with Minocycline After Spinal Cord Injury. J.W. Squair, J. Liu, R. Gopaul, A.V. Krassioukov, C.R. West. University of British Columbia, Canada and GF Strong Rehabilitation Centre, Canada. (1077.5) 11:30 Heat Exposure Improves Cognitive Performance in Persons with Higher Levels of Spinal Cord Injury. J.P. Handrakis, T.D. Tittley, O.F. Tascione, J. Bart, C. Barton, C. Bang, A.M. Spungen, W.A. Bauman. James J Peters Veterans Affairs Medical Center, New York Institute of Technology, School of Health Professions, James J. Peters VA Medical Center and Icahn School of Medicine at Mount Sinai. (1077.10) 11:45 A Triple Combination Approach Involving Nerve Transplantation, Glial Scar Digestion and Passive Exercise Promotes Cardiovascular Recovery After Spinal Cord Injury. R. Sachdeva, R. Gopaul, M. Jia, A. Monga, M. Ramer, A.V. Krassioukov. University of British Columbia, Canada. (1077.7) 12:00 Chronic, Complete Cervical6–7 Cord Injury: Distinct Autonomic, Cardiac and Vascular Deficits. H.L. Lujan, R.A. Mulder, S.E. DiCarlo. Wayne State University School of Medicine. (1077.6) 12:15 Passive Leg Cycling Comprehensively Restores Cerebrovascular Health After Experimental High-Thoracic Spinal Cord Injury. M. Jia, A.A. Phillips, N. Matin, A. Yung, M. Zheng, A. Lee, A. Monga, P. Kozlowski, A. Dorrence, A.V. Krassioukov. University of British Columbia, Canada, Michigan State University and G.F. Strong Rehabilitation Centre, Canada. (1077.13)
182
Chaired: C. De Miguel and J. Abais-Battad
3:30 4:00
Pre-Eclampsia and Hypertension Risk Later in Life. Jennifer Sasser. Univ. of Mississippi Med Ctr. T Regulatory Cells and Sex Differences in Hypertension Risk. Jennifer Sullivan. Augusta Univ. SCFAs, Microbiome and Hypertension Risk. Jennifer Pluznick. Johns Hopkins Medical School. Histone Deacetylases, NO and Hypertension Risk. Jennifer Pollock. Univ. of Alabama at Birmingham.
566. PATENT FORAMEN OVALE: THE HOLE STORY ENVIRONMENTAL AND EXERCISE PHYSIOLOGY Symposium (Sponsored by: Environmental and Exercise Physiology Section) Wed. 2:30 pm—McCormick Place Convention Center, W190B Chaired: A. Lovering and P. Wilmshurst 2:30 3:00 3:30 4:00
PFO: The “Hole” Story of Thermoregulation. James Davis. Indiana State University. PFO: The “Hole” Story of Hypoxia/Altitude. Glen Foster. Univ. of British Colubmia-Okanagan. PFO: The “Hole” Story of Exercise. Brett Fenster. National Jewish Health. PFO: The “Hole” Story of Diving. Peter Wilmshurst. Royal Stoke University Hospital.
567. NEW INSIGHTS INTO EPITHELIAL TRANSPORT: APPLICATION OF GENETIC MODELS Featured Topic (Sponsored by: Epithelial Transport Group) Wed. 2:30 pm—McCormick Place Convention Center, W192A Chaired: T. Rieg and R. Fenton 2:30
2:45
Chronic Loop Diuretic Treatment Mediates SegmentSpecific Hypertrophy in the Nephron. A. Krauson, E. Walczak, S. Iyer, N. Velarde, J. Nizar, V. Bhalla. Stanford University and BD Genomics. (857.12) Intestinal Adenylyl Cyclase 6 Mediates Cholera ToxinInduced Diarrhea.T. Rieg, I. Kaji,Y. Akiba, J. Kaunitz, S.B. Poulsen, J.A. Dominguez Rieg, R.A. Fenton. UCSD & VASDHS, UCLA & Greater LAVAHS, Aarhus University, Denmark and Bastyr University California. (703.3)
WEDNESDAY PHYSIOLOGY 3:00
3:15
3:30
3:45
4:00 4:15
AngII Hypertension Differentially Influences Sodium Transporters, Channels and Claudins in Female vs. Male FVB/N Mice. J.S. Manwani, K.M. Mirabito Collafella, D.L. Ralph, K.M. Denton, A.A. McDonough. Keck School of Medicine of USC, Cardiovascular Program, Monash Biomedicine Discovery Institute, Monash University, Australia and Erasmus Medical Center, Netherlands. (1007.54) Dual PDE3/4 Inhibition Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. M.A. Borchart, D.L. Gumina, T.A. Kronk, J.H. Sim, M.A. Blount. Emory University School of Medicine. (1007.57) The Protective Role of NHERF1 in Cisplatin-Induced Acute Kidney Injury. A.M. Bushau-Sprinkle, A.R. Sherwood, C.A. Conklin, M.T. Barati, T. Dupre, L. Siskind, K.B. Gagnon, S.J. Khundmiri, E.D. Lederer. University of Louisville, Howard University and Robley Rex Veteran Affairs Medical Center. (694.1) Blockade of AT2R Causes Hyperkalemia by Stimulating the Basolateral Kir4.1 and Apical NCC in the Distal Convoluted Tubule (DCT). P. Wu, Z. Gao, M. Wang, X. Su, D. Lin, W. Wang. New York Medical College, Medical College of Xiamen University, People’s Republic of China. (1007.23) A Cyclic-AMP Dependent Pathway Regulates Intestinal Oxalate Secretion. J. Whittamore, M. Hatch. University of Florida. (1007.30) Deletion of Xenotropic and Polytropic Retrovirus Receptor 1 in Mouse Nephron Causes Renal Fanconi Syndrome and Hypophosphatemic Rickets. C. Ansermet, M. Moor, G. Centeno, M. Auberson, D. Hu, R. Barron, S. Nikolaeva, B. Haenzi, N. Katanaeva, I. Gautschi, V. Katanaev, S. Rotman, R. Koesters, L. Schild, S. Pradervand, O. Bonny, D. Firsov. Université de Lausanne, Switzerland, Harvard School of Dental Medicine, Institute of Evolutionary Physiology and Biochemistry, Russian Federation, University Hospital of Lausanne, Switzerland and Université Pierre et Marie Curie, France. (857.9)
568. FIGHTING THE FAT: LIFESTYLE APPROACHES TO PROTECT AGAINST ADIPOSE TISSUE AND LIVER DYSFUNCTION Symposium
4:00
569. NOVEL IMAGING TECHNOLOGIES IN REPRODUCTIVE PHYSIOLOGY Symposium (Supported by Fujifilm VisualSonics, Inc.) (Sponsored by: Endocrinology and Metabolism Section) Wed. 2:30 pm—McCormick Place Convention Center, W193 Chaired: L.M. Yamaleyeva and S.H. Lindsey 2:30 3:00 3:30
4:00
Symposium (Sponsored by: Translational Physiology Interest Group) Wed. 2:30 pm—McCormick Place Convention Center, W196A Chaired: P. Kleinbongard and K. Ait-Aissa 2:30 2:55
3:20
Chaired: D. Wright 2:30 3:00 3:30
Turn Down the Burn: How Exercise can Protect Against Liver and Adipose Inflammation. Daivd Wright. Univ. of Guelph. Heat Shock Proteins in the Treatment and Prevention of Disregulated Adipose and Liver Metabolism. Paige Geiger. Univ. of Kansas Med. Ctr. Managing Nonalcoholic Fatty Liver Disease: Are All Lifestyle Interventions Created Equal. R. Rector. Univ. of Missouri, Columbia.
Placenta Imaging Project: Using MRI to Understand Development. Antonio Frias. Oregon Health and Science University. Placental Vascular Patterning in the Mouse: Relating Hemodynamics to Vascular Architecture. John Sled. University of Toronto. Contrast Enhanced Ultrasound/Microbubble Technology for Targeted Delivery of Genes and Quantification of Microvessel Flow in the Primate. Gerald Pepe. Eastern Virginia Medical School. Photoacoustic Imaging for in vivo Quantification of Placental Oxygenation. Liliya Yamaleyeva. Wake Forest School of Medicine.
570. VASODILATION IN HUMAN MICROVESSELS: FROM BED TO BENCH AND BACK
(Sponsored by: Endocrinology and Metabolism Section) Wed. 2:30 pm—McCormick Place Convention Center, W192B
Maternal Phytosterol Supplementation to a High Cholesterol Diet Modulates Hepatic Lipid Response in Offspring of ApoE Deficient Mice. Todd Rideout. SUNY Univ. at Buffalo.
3:45 4:10
Vascular Effects of Exercise and Other Lifestyle Factors in Humans. Shane Phillips. University of Chicago at Illinois. Ischemic Preconditioning as an Intervention to Improve Motor Function in Stroke Subjects: Vascular and Neural Considerations. Matt Durand. Medical College of Wisconsin. Remote Preconditioning Effect on Vasculature and Myocardium. Petra Kleinbongard. University of Essen. Healthy Aging in the Human Vasculature Contributions of External Stressors on Endothelial Function. Anthony Donato. University of Utah. Role of Autophagy in Endothelial Cell Function in Diabetics. Jessica Fetterman. Boston University School of Medicine.
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PHYSIOLOGY WEDNESDAY
571. LEPTIN BEYOND APPETITE REGULATION Symposium
573. OMICS APPROACHES TO UNDERSTANDING MUSCLE BIOLOGY
(Sponsored by: Translational Physiology Interest Group)
Symposium
Wed. 2:30 pm—McCormick Place Convention Center, W196C
(Sponsored by: Cell and Molecular Physiology Section) Wed. 2:30 pm—McCormick Place Convention Center, W194B
Chaired: P. Singh and P. Cohen 2:30 Leptin and Leptin Resistance: Implications for Cardiovascular Disease. Virend Somers. Mayo Clinic. 3:00 Mechanistic Role of Leptin in Modulating Hyperglycemia in Poorly-Controlled Diabetes. Rachel Perry. Yale University School of Medicine. 3:30 Adipose Tissue Dynamics during Weight Gain: The Leptin Story. Prachi Singh. Mayo Clinic. 4:00 Peripheral Actions of Leptin: From Metabolism to Oncogenesis. Philipp Scherer. The University of Texas Southwestern Medical Center.
572. NEW CONCEPTS OF THE RENIN-ANGIOTENSIN SYSTEM IN CARDIOVASCULAR PATHOPHYSIOLOGY Symposium
Chaired: J.G. Burniston and Y-W. Chen 2:30 DamID Profiling during Myogenesis Defines Heterochromatin Flux at the Nuclear Envelop. Jelena Perovanovic. National Institues of Health, Bethesda. 3:00 Beyond Timekeeping, the Transcriptional Landscape of the Molecular Clock in Skeletal Muscle. Karyn Esser. University of Florida. 3:30 Proteomics Insights in to Insulin Resistance in Muscle. Lawrence Mandarino. Mayo Clinic. 4:00 Metabolomics and Fluxomics Reveal Pathways underlying Enhanced Muscle Performance in Exercise. Charles Burant. University of Michigan Medical School.
574. HYDRATION AND VASOPRESSIN BEYOND THE KIDNEY
Pan-American Societies (SFiB)
2:30 3:00 3:30 4:00
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Symposium
Wed. 2:30 pm—McCormick Place Convention Center, W192C
(Supported by Danone Research)
Chaired: M.J. Campagnole-Santos and E.A. Aiello
(Sponsored by: Water and Electrolyte Homeostasis Section)
Cardioprotective Role of Angiotensin-(1-9) in the Cardiovascular System. Sergio Lavandero. Univ. of Chile and P. Univ. Catolica de Chile. Pathophysiological Role of the Aldosterone G-Protein Coupled Receptor GPER in the Heart. Alejandro Orlowski. Univ. Nacional de la Plata, Argentina. New Insights into Alamandine Signaling in Cardiac Myocytes. Silvia Guatimosim. Univ. Fed. de Minas Gerais, Brazil. Alamandina and Heart Failure. Robson Santos. Univ. Fed. de Minas Gerais, Brazil.
Wed. 2:30 pm—McCormick Place Convention Center, W190A Chaired: S. Kavouras and L. Bankir 2:30 3:00 3:30 4:00
Central Effects of Vasopressin in the Brain. Daniel Bichet. Univ. of Montreal. The Vasopressin Paradox: Not a Vasoconstrictor? Georges Bakris. Univ. of Chicago. Vasopressin as a Stress Hormone. Ivan Tack. CHU Toulouse, Hopital Rangueil. From (De)Hydration Science towards Biomarkers for Hydration for Health. Jeanne Bottin. Danone Nutricia Research.
SUNDAY, APRIL 23 Across Societies 575. COMPUTERS IN RESEARCH AND TEACHING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: 12:45 pm–3:00 pm Recognizing that techniques and issues related to teaching and the use of computers in research and teaching crosses all biomedical disciplines, EB 2017 has combined education posters from all participating societies. Please note: Posters are on display Sunday through Tuesday. Presentation time is for Sunday only. T1 575.1 Grasping the Idea: Using Hand Dynamometry to Teach the Scientific Method to Elementary Students. R. Sledge, W.J. Norris, E.K. Merritt. Appalachian State University. T3 575.2 Student-Produced Videos Enhance Learning in a Freshman Cellular and Molecular Biology Course. H. Chen, Y. Ellenbogen, M. Ng, K. Brar, J. Lee, C. Lee, B. Lee, S. Nastos. McMaster University, Canada. T5 575.3 Dynamic Modeling Shows Long-Term Gene Expression Is Highly Dependent on Macromolecular Crowding. A.R. Shim, L. Almassalha, H. Matsuda, R. Nap, I. Szleifer. Northwestern University.
576. TEACHING, LEARNING AND TESTING IN THE BIOLOGICAL AND BIOMEDICAL SCIENCES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: 12:45 pm–3:00 pm Recognizing that techniques and issues related to teaching and the use of computers in research and teaching crosses all biomedical disciplines, EB 2017 has combined education posters from all participating societies. Please note: Posters are on display Sunday through Tuesday. Presentation time is for Sunday only. T7 576.1 Team-Based Learning in the Neuroanatomy Lab of an Undergraduate Human Anatomy and Physiology Course—A Lesson Study. J. Schanandore, S. Liu, C. Schwartz, R. Stapley. University of Wisconsin-La Crosse. T8 576.2 Interactions Between Student Attitudes, Affect and Outcomes During a Transition to an Active Learning Format in Introductory Physiology. S.J. Malmquist, W.F. Collins; III. Stony Brook University.
T9 576.3 Show Them You Care: Faculty Responsiveness Augments Student Buy-In to Active Learning. X. Chen, A. Cavanagh, M. Graham. University of Connecticut and Yale University. T10 576.4 A Case Study for Teaching Neuroanatomy Structure and Function: Doctor, Why Am I So Tired and Dizzy? J.A. Stokes, A. Grosofsky. Beloit College. T11 576.5 Expanding on Case Studies: Combined Active Learning Techniques in Small Undergraduate Physiology Classrooms. C. Caldari. Centenary College of Louisiana. T12 576.6 Educating the Educators: A Unique Physiologyand Anatomy-Based Educator Workshop in the Wiregrass Region. A.A. Vasauskas, C.L. Richardson, S.A. Anderson, A.L. Robinson. Alabama College of Osteopathic Medicine. T13 576.7 Active Methodologies Improve the Performance of Medical Students in Physiology Assessments. L.H. Montrezor. T14 576.8 The Comparison of Student Performance Between Flipped Classroom and Traditional Teaching Approach. C. Gopalan, M.C. Klann. Southern Illinois University Edwardsville. T15 576.9 The Clinical Reasoning Conference: A FlippedClassroom, Case-Based Approach to Teaching and Learning in the Pre-Clerkship Medical Curriculum. R.P. Sullivan, D.J. Karras, D.R. Schwartz, G. Sterling. Lewis Katz School of Medicine at Temple University. T16 576.10 Impact of Learning Approaches on Academic Performance of Preclinical Medical Students: Superficial vs Deep. Z. Kayali, F.K. Abdulwali, A.A. Peeran, A.S. Obad, M.A. Shareef. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T17 576.11 Effectiveness of a “Semi-Flipped” Class in the Teaching of Pharmacology and Its Prerequisites. R.A. Pena Silva, D. Santamaria Rodriguez, A. Avalo Azcarate, L. Chaparro Moreno, L. Sierra Penuela, S. Jaramillo Rincon, S. Gomez Montero. Universidad de los Andes, Colombia, Clínica de Marly, Colombia and Hospital Italiano de Buenos Aires, Argentina. T18 576.12 Redesigning a Comprehensive Integrated Pharmacology Course for Active Learning in a CompetencyBased Curriculum. S.A. Marsh, M.F. Paine, K.M. Gibson. Washington State University. T19 576.13 Student Survey Results on the Integration of Active Learning Exercises in a Dental Education Self-Learning Setting. L. Ruest, K.K. Svoboda, L.A. Opperman. Texas A&M College of Dentistry. T20 576.14 Problem-Based Learning Increases Motivation and Learning Strategy Use in Both Low- and High-Achieving Students in an Upper-Level Undergraduate Physiology Course. M.K. Rhoads, L. Xiang, B.M. Franklin, J.L. Osborn. University of Kentucky and Weber State University.
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T21 576.15 Medical Students’ Perceptions of Physiology Practical Animal-Handling and Virtual Classes in ProblemBased Learning (PBL) Method. M.D. Durand, C.B. Restini, R.B. Bestetti, L.B. Couto. University of Ribeirão Preto, Brazil. T22 576.16 Early Echocardiography Experience Assists in Improving and Retaining Knowledge of Cardiac Anatomy and Physiology for Medical Students. A. Elmoselhi, M. Eladl, M. Seif. University of Sharjah, United Arab Emirates and University Hospital Sharjah, United Arab Emirates. T23 576.17 Dramatization of Starling Forces: An Interactive Learning Approach. B.W. Connor, H. Carvalho. VTCSOM. T24 576.18 Basic Integrative Disciplines in a Dentistry Course: 10 Years Evaluation of the Experience of Piracicaba Dental School of the University of Campinas, Brazil. F.K. Marcondes. Piracicaba Dental School and UNICAMP, Brazil. T25 576.19 Epistemic Cognition in Medicine: A Review of Literature and Implications for Medical Educators. J.L. Eastwood, E. Koppelman-White, M. Mi, J.A. Wasserman, E.F. Krug III, B. Joyce, B. Joyce. Burrell College of Osteopathic Medicine, Oakland University and Oakland University William Beaumont School of Medicine. T26 576.20 Vertical Integration of Basic Science and Clinical Medicine During Case Based Learning Sessions for Third Year Medical Students. S.K. ElSayed, I. Niculescu. OUWB School of Medicine and OUWB School of Medicine Beaumont Health System. T27 576.21 Clinical Research 101: A Way to Showcase Healthcare Professions in High-School Students Using PhUn Week. A.N. Gurovich, F. Morales, K. Terry. Indiana State University and South Vermillion High School. T28 576.22 Utilizing Pre- And Post-Exercise Changes in Heart Rate as a Method of Teaching the Scientific Method to Second Grade Students. J.C. Taylor, B. Mercier. Mississippi Osteopathic Medical Association and Sacred Heart Elementary School. T29 576.23 A Summer PhUn Week for English Language Learners. P.A. Halpin, R.M. Pugh. University of New Hampshire at Manchester. T30 576.24 What Are You Blubbering About? A Study of Comparative Cold Physiology. M.M. Clarke, D.H. Craighead, B.K. Alba, S.W. Shank. The Pennsylvania State University. T31 576.25 Annual PhUN Week Service Learning Events Improve Student Content Mastery and Civic Engagement. E.M. Rhinehart. Susquehanna University. T32 576.26 An Undergraduate Teaching Course: Students Learning Physiology Through Teaching. L.C. Anderson. University of Minnesota. T33 576.27 A Comparison of High Fidelity Patient Simulations and Computerized Clinical Cases on Undergraduate Student Learning of Physiology. D.M. Harris, W. Li. University of Central Florida. T34 576.28 Theory Into Practice: Investigation of the Service Learning Pedagogy in Undergraduate Physiology Education. J.M. Redden. University of Connecticut.
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T35 576.29 Does Size Really Matter? a Comparison of Class Size and Student Outcomes in Introductory Physiology Courses. C.A. Gibbons Kroeker. University of Calgary, Canada and Ambrose University, Canada. T36 576.30 A Survey of Student Preconceptions About Physiology. K.L. Walton. Missouri Western State University. T37 576.31 Building Bridges: Addressing Real World Problems with Technology But Without a Protocol Using Design Instruction in a Physiology Lab. A. Vaidyam, J.T. Batts, H. Chan, N. Pelaez. Purdue. T38 576.32 Physiology Labs at the Cutting Edge: Multidisciplinary Design of Systems and Devices for Physiology Measurements. R.H. Rozner, J.T. Batts, G.K. Nossa, C. Pullins, N. Pelaez. Purdue. T39 576.33 Course-Embedded Undergraduate Research in an Animal Physiology Laboratory Course. S. Liu. University of Wisconsin-La Crosse. T40 576.34 Introducing Informal Communication of Science Within an Undergraduate Anatomy and Physiology Course. A.M. Petzold, R. Dunbar. University of Minnesota Rochester. T41 576.35 “The Locomotion”: Not the Pop Song but an Activity Designed to Integrate Energetics and Mechanics to Understand Human Movement. S. Elmer. Michigan Tech University. T42 576.36 A Model for Enhancing Student Gains During Experiential Learning Opportunities. P.A. Halpin, A.E. Donahue, K.M. Johnson. University of New Hampshire at Manchester and Beloit College. T43 576.37 The QMRC Method: A Systematic Approach for Undergraduate Students to Understand, Analyze, and Communicate Data Figures from Primary Research Articles. K. Hinkle. Norwich University. T44 576.38 An Innovative Approach to Teaching the History of Physiology. S. Anjur. IMSA. T45 576.39 The Use of Livescribe™ Echo® Pen Recordings to Make Videos of Jeopardy-Like Questions to Encourage Spaced Out, Interleaved Study by Students. J.S. Chapman, L. Denofrio-Corrales. Heartland Community College. T46 576.40 An Analysis of Assessment Modalities in HighEnrollment Course Sections. J. Kingsbury, T. Penkrot, C.S. Lisenbee, J.K. Hyatt. Arizona State University. T47 576.41 A Comparison of Student Profiles and Performance in an Introductory Non-Majors Biology Course Offered 100% in the Classroom vs. 100% Online. M.A. Daggett. Missouri Western State University. T48 576.42 Aligning Introductory Biology to Vision and Change Recommendations. K.A. Wilkinson, S. Lambrecht, S. Anand. San Jose State University. T49 576.43 Lessons from a Hybrid Undergraduate Human Biology Course. K. Seiler. Champlain College. T50 576.44 Lessons from Fundulus Melanophores: Integrative Approach in Biology Education. S.M. Hong. University of Delaware.
T51 576.45 Factors Directing Preclinical Medical Students Toward Specialty of Choice. F.N. Shacfe, R.I. Alhomoudi, A.A. Peeran, A.I. Abdeh, A.S. Obad, M.A. Shareef. Alfaisal Unversity, Saudi Arabia, Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T52 576.46 Low Intrinsic Motivation but Not GRIT Is Predictive of Low Performing Medical Students. R.A. Augustyniak, J. Chin, H. Lujan, R.N. Cortright, S.E. DiCarlo. Edward Via College of Osteopathic Medicine- Carolinas, Wayne State University School of Medicine and East Carolina University. T53 576.47 Resource Utilization Among Students in Different Professional Programs Enrolled in the Same Human Physiology Course and Its Correlation to Exam Performance. K. LePard, C.J. Skok, K. Sondgeroth. Midwestern Unniversity. T54 576.48 Challenges with Initial Implementation of an Intelligent Formative Assessment System. E. Wilson, J.D. Kibble, C. Bellew, C. Hernandez, A. Castiglioni, A. Khan, C. Kamin, A. Riordan, S. Dauner, D. Lorens, A. Gangopadhyaya, N. Rajagopal, S. Gaglani, R. Haynes, M. Lineberry. University of Central Florida, University of Illinois at Chicago and Knowledge Diffusion Inc. T55 576.49 Inspection of Medical Students’ Quality of Life in an Unstable Nation, Yemen: Is WHOQOL-BREF Still Valid and Reliable? A.A. Ba Abbad, H.A. Alaidroos, A. Bawazir, M.A. Al-Gunaid, M.O. Al-Ghurabi, F.K. Abdulwali, A.S. Obad, M.A. Shareef. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical. T56 576.50 Investigation of Factors Impacting Medical Students’ Quality of Life Under Current Civil War in Yemen. M.O. Al-Ghurabi, M.A. Al-Gunaid, H.A. Alaidroos, A.A. BaAbbad, A.A. Bawazir, F.K. Abdulwali, M.A. Shareef, A.S. Obad. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T57 576.51 The Use of a Case Study from Pop Culture Improves Student Test Scores and Evaluations in a Cardiovascular Physiology Class. R. Berg. Frederiksberg and Bispebjerg Hospitals, Denmark.
T58 576.52 Clinical Scenario Videos Improve D.M.D Students’ Perception of the Basic Sciences and Ability to Apply Content Knowledge. C.J. Metz, M.J. Metz. University of Louisville. T59 576.53 Subways and Role-Plays: Using Analogies to Understand Matter and Energy Flow. K. Hull, P. Marx, M. Jensen. Bishop’s University, Canada and University of Minnesota. T60 576.54 The Wright Cardiac Cycle Table: A Novel Tool to Teach the Cardiac Cycle. B.E. Wright. Ross University School of Medicine, Dominica. T61 576.55 Tonicity and Osmolarity, Why Are They Confusing? S.Y. Kuang. Oakland University William Beaumont School of Medicine. T62 576.56 Open Science for Medical Students: Quincke’s Research Scholarship. A.J. Dorta-Contreras, B. PadillaDocal, J.P. Martínez-Larrarte, I. Iglesias-González, L. Cárdenas-de-Baños, W. Castillo-González, C. GonzálezLosada. Labcel, Cuba. T63 576.57 Observation, Observation, Observation! Anomalies Seen and Learned from a Prosected Cadaver. C. Mullens, P.S. Klinkhachorn. West Virginia University. T64 576.58 the Story of Two Tendons and 20,000 Miles Apart: From Anatomical and Functional Perspectives in Education. P.S. Klinkhachorn, R.K. Mannan, C.L. Mullens. West Virginia University.
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Anatomy 577. FORM, FUNCTION AND MORPHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E1 577.1 Ultrastructural Analysis of the Tongue of White-Eared-Opossum (Didelphis albiventris) B.T. Schäfer, A. Teixeira Filho, I. Watanabe. University of São Paulo, Brazil and Federal University of Pelotas, Brazil. E2 577.2 Anatomical Descriptions of Developing Hypoglossal Motor Neurons in the Green Frog, Lithobates clamitans and Bullfrog, Lithobates catesbeiana Through Metamorphosis. C.W. Anderson, A.J. Carroll. Idaho State University. E3 577.3 Variation of Facial Musculature Between Wolves and Domestic Dogs: Evolutionary Divergence in Facial Movement. A. Burrows, R. Diogo, B. Waller, J. Kaminski. Duquesne University, Howard University and University of Portsmouth, United Kingdom. E4 577.4 Seriated CT-Scan of the Cranium in a Crocodylus niloticus from Madagascar (215 mm Long) in the Three Planes of the Space. P.P. Le Floch-Prigent, S. Verdeille. Université de Versailles-Saint Quentin, France and Clinique du Val d’Or, France. E5 577.5 Modeling Complex Cranial Joints in Varanus exanthematicus A.T. Wilken, K.M. Middleton, K.C. Sellers, I.N. Cost, J.L. Davis, C.M. Holliday. University of MissouriColumbia and Southern Indiana University. E6 577.6 Bending Properties of the Jugal Bone in Mallard Ducks and Its Significance for Cranial Biomechanics. C.J. Smith, C.M. Holliday, K.M. Middleton, A.M. Bailleul. University of Missouri and University of Missouri School of Medicine. E7 577.7 Comparative Anatomy and Biomechanics of the Feeding Apparatus of Parrots (Aves: Psittaciformes) I.N. Cost, K.M. Middleton, L.M. Witmer, M.S. Echols, C.M. Holliday. University of Missouri, Ohio University and Echols Veterinary Services. E8 577.8 Functional-Morphological Diversity and Complexity of the Larynx as a Basis for Vocal Complexity in Birds: Analogies to Human Speech. D.G. Homberger. Louisiana State University. E9 577.9 Free-Body Diagram Force Analysis in 2D and 3D: A Tool to Study Comparative Vertebrate Biomechanics. M.L. Osborn, A. Rau, J. Ge, D.G. Homberger. Lousiana State University School of Veterinary Medicine and Louisiana State University. E10 577.10 A Mathematical Model of Beaver Incisor Tooth Morphology. C.E. Rinaldi, S.M. Kuhn-Hendricks, G.M. Erickson. University of Texas-Southwestern and Florida State University.
E11 577.11 Mechanical and Biological Response of Alveolar Bone with Tooth Under Traumatic Occlusion in Rats: Experimental Analysis Associated to Computer Simulation. A. Rossi, A.R. Freire, R. Okamoto, S.T. Costa, P.R. Botacin, F.B. Prado. Piracicaba Dental School—University of CampinasUNICAMP, Brazil and Araçatuba Dental School—Paulista State University-UNESP, Brazil. E12 577.12 Musculoskeletal Morphology of the Hip and Thigh of the Black-Footed Ferret (Mustela nigripes) V.L. Naples. Northern Illinois University. E13 577.13 A Major Paradigm Shift in Fish, Tetrapod and Limb Evolution: Characteristic Tetrapod Musculoskeletal Limb Phenotype Emerged More Than 400 MYA in Basal Lobe-Finned Fishes. R. Diogo, J. Molnar, B. Esteve-Altava, P. Johnson. Howard University and University of Auckland, New Zealand. E14 577.14 The Effect of Growth Rate and Biomechanical Loading on Bone Laminarity in the Emu Hindlimb. A. Kuehn, E.L. Simons, A.H. Lee, R.P. Main. Midwestern University and Purdue University. E15 577.15 Comparing Femur Cross-Sectional Morphology in Young Outbred Mice Following Daily Exposure to Muscle-, Impact-, or Combined Loading of the Hind Limb Skeleton. A.N. Smolinsky, K.M. Middleton. University of Missouri. E16 577.16 Low-Impact Climbing Exercise During Growth Enhances Skeletal Muscle Function. J. Organ, K. Biro, B. Vickery, G. Monnin, D. Waning. Indiana University School of Medicine and Pennsylvania State University. E17 577.17 Chikungunya Virus Infection Alters New Bone Formation Associated with Pre-Existing Post-Traumatic Osteoarthritis. M.A. McNulty, B.A. Goupil, A. Moses, C.N. Mores. Louisiana State University School of Veterinary Medicine and Indiana University School of Medicine. E18 577.18 Effects of Perinatal Circadian Programming on Activity and Skeletal Morphology in C57BL/6 Mice. S.J. Peacock, K. Bates, O.O. Talton, L.C. Schulz, K.M. Middleton. University of Missouri. E19 577.19 Ontogenetic Changes in the Terrestrial Locomotion of the American Alligator (Alligator mississippiensis) K. Manfredi, J. Georgi. Midwestern University. E20 577.20 Potus flavus: Linking Tail Integumentary Function and Microanatomical Structure. S.A. Ruiz Palacios, J.H. Plochocki, J.R. Rodriguez-Sosa, M.I. Hall. Midwestern University. E21 577.21 Copulatory Fit of Common Bottlenose Dolphin (Tursiops truncatus) Genitalia. D. Orbach, P. Brennan. Dalhousie University, Canada and Mount Holyoke College.
578. BIOLOGICAL ANTHROPOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Evolution/Anthropology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E22 578.1 First Detailed Anatomical Study of Bonobos Exposes Just-So Stories of Human Evolution, Anatomy, Variations, Bipedalism and Tool Use. R. Diogo. Howard University.
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SUNDAY ANATOMY E23 578.2 Craniofacial Adaptation and Upper Respiratory Function Among High-Altitude Inhabitants. L.N. Butaric, R.P. Klocke. Des Moines University. E24 578.3 Differences in Foramen Magnum Size and Shape Among Sexes in Diverse Populations. A.W. Koons, M.L. Russell, K.N. Bliss, K.R. Mangus, M.J. Zdilla. West Liberty University. E25 578.4 The Effect of Dental Senescence on Fecal Particle Size for Propithecus diadema in the Fragmented and Pristine Forests of Tsinjoarivo, Madagascar. K.S. Heffernan, K.E. Samonds, M. Irwin. Northern Illinois University. E26 578.5 The Prevalence of Supraorbital Foramina and Notches Among Different Populations, Sexes, and Sides. K.N. Bliss, A.W. Koons, M.L. Russell, K.R. Mangus, M.J. Zdilla. West Liberty University. E27 578.6 Comparison Analysis of Metopism Prevalence in Sexes and Various Populations. K.N. Bliss, M.L. Russell, A.W. Koons, K.R. Mangus, M.J. Zdilla. West Liberty University. E28 578.7 Phylogenetic Influences on Tooth Mineral Density in Primates. L.M. Zeigler, K.A. Paddock, C.M. Ficorilli, M.E. Millen, B.M. Harvey, R.T. Hogg, C.J. Vinyard, M.M. Muchlinski, V.B. DeLeon, T.D. Smith. Slippery Rock Univ. E29 578.8 Synchondroses of the Anterior Chondrocranium in Primates. S. Engel, J.L. Wu, C. Llera, M.P. Zumpano, V.B. DeLeon, T. Smith. Slippery Rock University, University of Florida and New York Chiropractic College. E30 578.9 Tooth Mineral Density in Primates: Effects of Developmental Strategies and Dietary Preference. K.A. Paddock, L.M. Zeigler, B.M. Harvey, M.E. Millen, C. Vinyard, M.M. Muchlinski, V.B. DeLeon, T.D. Smith. Slippery Rock Univ, NEOMED, University of North Texas and University of Florida. E31 578.10 Adult Female Human Bony Pelvis Obstetric Morphology Differences with Respect to Age Are Not Due to Selection. B.M. Auerbach. The University of Tennessee. E32 578.11 Femur Measurement in Photoanthropometric Analysis. Surface Projection of Inguinal Ligament, with or Without Garments, Is a Reliable Landmark? M. Cusimano. FORMED conv. Second University of Naples, Italy. E33 578.12 Phylogenetic Utility of Mammalian Postcranial Characters. R.C. McCarthy, T.A. DiVito III, J. Bains, M. Fatima. Benedictine University and Nova Southeastern University. E34 578.13 Sexual Dimorphism in Facial Fluctuating Asymmetry Among Hausa Population of Nigeria M.G. Taura, L. Adamu, B. Danborno. Bayero University Kano, Nigeria, University of Bisha, Saudi Arabia, Ahmadu Bello University and Zaria, Nigeria. E35 578.14 Sexual Anatomy Differs Between Orthograde and Pronograde Primates and Other Mammals: Implications for Human Evolution. M.I. Hall, J.H. Plochocki, J.R. RodriguezSosa, S. Ruiz. Midwestern University. E36 578.15 Osteons and Osteocytes in Belanger’s Tree Shrews (Tupaia belangeri)—A Comparative Study. Q. Wang, V. Kondru, M.J. Kesterke, J.Q. Feng. Texas A&M University College of Dentistry. E37 578.16 Cranial and Appendicular Skeletal Elements Show Correlated Responses to Selection Among Large-Bodied and Small-Bodied Tamarins. E.R. Agosto, B.M. Auerbach. University of Tennessee- Knoxville. E38 578.17 Spinal Process Shape and Vertebral Immobility in Hominoids and Hox9 Mutant Mice. A.L. Machnicki, S.M. Hrycaj, D.M. Wellik, P.L. Reno. Pennsylvania State University and University of Michigan.
E39 578.18 Musser’s Cryptids: Resolving Unknown or Disputed Species Identities in Scientific Collections. K. Tuttle. Northern Illinois University.
579. VERTEBRATE PALEONTOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Vertebrate Paleontology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E40 579.1 Biomechanics and the Evolution of the Crocodyliform Skull. K.C. Sellers, K.M. Middleton, J.L. Davis, C.M. Holliday. University of Missouri and University of Southern Indiana. E41 579.2 Restoring Dinosaur Cephalic Vascular Anatomy and Thermophysiology Using Osteological Correlates and Anastomotic Connections. W.R. Porter, L.M. Witmer. Ohio University. E42 579.3 Seriated CT-Scan of an Egg in Aepornis maximus (Madagascar) and Reconstructions. P.P. Le FlochPrigent, J. Gillot, S. Verdeille. Université de Versailles-Saint Quentin, France, Metropolitan, Librairie Scientifique Alain Brieux, France and Clinique du Val d’Or, France. E43 579.4 Changes in Pectoral Appendicular Muscle Anatomy and Function Over the Water-Land Transition in Tetrapods. J. Molnar, J. Hutchinson, R. Diogo, S. Pierce. Howard University College of Medicine, Royal Veterinary College, United Kingdom and Harvard University. E44 579.5 The Nasal Salt Gland of Extant Birds: Anatomical Structure and Its Relevance for Inferring the Behavior and Habitat Preferences of Extinct Birds. E.G. Caggiano, D. Cerio, W.R. Porter, R.C. Ridgely, L.M. Witmer. Ohio University.
580. ANATOMY EDUCATION: TECHNOLOGYASSISTED LEARNING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E45 580.1 The Use of Softchalk Modules to Prepare First Year Medical Students for Upper Limb Cadaver Dissections. T.R. Tooley, M. Ahmed, L. Helland, S. Dykowski, M. Barremkala. Oakland University William Beaumont School of Medicine. E46 580.2 Telequantum Medical Technologies Taught, Practiced, and Assessed by Medical Students in a Millennial Anatomy Lab Developing Telemedicine Skills. B. Benninger, W. Chen. Western University of Health Sciences COMP-Northwest. E47 580.3 Development of an Effective iBook to Educate Veterinary Students About the Ovariohysterectomy Procedure on Small Animals. C.C. Ng, C. Schmiedt, J. Moore, K. Mount, K. Brennan, J. Daugherty. University of Illinois at Chicago and University of Georgia.
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ANATOMY SUNDAY E48 580.4 Macanatomy Pathology Learning Tool Project. B. Cao, X. Brual, A. Kurdina, I. Bayer, B. Wainman. McMaster University, Canada. E49 580.5 Using Focus Stacking in Anatomical Imaging: Does It Make a Difference? S.C. McWatt, L.C. Jadeski. University of Guelph, Canada. E50 580.6 Use of OneNote as a Platform for Anatomical Education. A. Campbell, K. Wilson, J. Olson. A.T. Still University. E51 580.7 Assessing Emotional Stress, Active Recall and Digital Spaced-Learning Media in the Study of Thoracic Gross Anatomy by Medical Students. R. Cole, D. McHugh. Frank H. Netter MD School of Medicine and Quinnipiac University. E52 580.8 A Pilot Study Examining the Impact of Two-Dimensional Computer Images and ThreeDimensional Stereoscopic Images of the Pelvic Muscles and Neurovasculature on Short-Term and Long-Term Retention of Anatomical Information for First-Year Medical Students. E.R. Meyer, A.M. James, D. Cui. University of Mississippi Medical Center. E53 580.9 An Interactive Program Incorporating 3D Models and 2D Illustrations for Enhanced Prostate MRI Training. T. Raber, L. Lebowicz, A. Oto, C. Westin, K. Brennan, D. Hughes. University of Illinois at Chicago and University of Chicago. E54 580.10 The Development of a Globally Accessible Interactive Anatomy Web Atlas. A. Mordhorst, M. Fejtek, A. Siddiqui, C. Krebs. University of British Columbia, Canada. E55 580.11 BlueLink Resources for Dental Head and Neck Anatomy: The Effectiveness of Tailored Multimedia. G.M. Fox, K. Alsup. University of Michigan Medical School. E56 580.12 The Anatomy of Traditional and E-Learning Education: How the Spatial Ability of Learners Can Impact Learning Outcomes. S.E. Van Nuland, K.A. Rogers. The University of Western Ontario, Canada.
581. ANATOMY EDUCATION: ACTIVE LEARNING, FLIPPED CLASSROOM, TBL
E61 581.5 The Benefits of Pair-Share Concept Mapping in Anatomy and Embryology. C. Elzie, C.W. Goodmurphy. Eastern Virginia Medical School. E62 581.6 Early Implementation of a Team Based Learning Session Focusing on Study Strategies and Content Knowledge Expectations Improves Student Performance on Their First Anatomy Exam. E. Johnson. Alabama College of Osteopathic Medicine. E63 581.7 Does Team-Based Learning Have a Positive Effect on Student Learning Outcomes in a Medical Developmental Anatomy Course? H. Abisamra, B. Treadway, M. Conway. University of Mississippi Medical Center. E64 581.8 Developing a Team-Based Learning Module for Large Classes in Medical School. J. Prange-Kiel, J.G. Champine, A.J. Winkler, D.M. Twickler. University of Texas Southwestern Medical Center at Dallas. E65 581.9 A Formal Interprofessional Ultrasound Curriculum Between Medical and Physical Therapy Students in the First Year Gross Anatomy Course. C.M. Gibbs, J.A. Knight, S.E. Van Nuland, A. Bhagra, N.J. Hellyer, N.R. Langley. Mayo Clinic School of Medicine, The University of Western Ontario, Canada, Mayo Clinic and Mayo Clinic College of Medicine and Science. E66 581.10 Clinical Educators’ Views of a Paired Anatomy Teaching Assistant and Clinician Teaching Model for Ultrasound Training During Gross Anatomy. D.F. Royer, J.L. Kendall. University of Colorado School of Medicine and Denver Health System. E67 581.11 Withdrawn. E68 581.12 Think FAST: Using a Clinical Ultrasound Examination to Study Abdominal Anatomy. L.A. Hoffman. Indiana University School of Medicine. E69 581.13 Evaluation of a New Temporally and Fiscally Economical Ultrasound Training Program for First-Year Medical Students. N.L. Mason, J. Puglisi, A. Mullen, B. Kim. California Northstate University College of Medicine.
582. ANATOMY EDUCATION: TEACHING AND LEARNING STRATEGIES AND METHODS
Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E57 581.1 Flipping the Anatomy and Neuroanatomy Classrooms in the First Year of Dental School. R.E. Druzinsky, A.F. Doubleday. University of Illinois. E58 581.2 Student Attitudes Toward a Flipped Classroom Design for Circulatory System in Medical School Gross Anatomy. S. Curran, D. Royer. University of Colorado Anschutz Medical Campus and University of Colorado School of Medicine. E59 581.3 A Pilot Study Into Flipping Neuroanatomy— Student Performance and Experience Results. E. Jennings, S. Long. James Cook University, Australia. E60 581.4 Using Practical-Based Team Based Learning as a Tool for Providing an Immediate Feedback to the Students During Learning Anatomy. M.A. Eladl, A.A. Jaffar, A. Ranade. College of Medicine, University of Sharjah, United Arab Emirates, Mansoura University, Egypt and Dalhousie University, Canada.
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Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E70 582.1 The Use of Clay Models to Teach Pelvic Anatomy to First and Second Year Medical Students at OUWB School of Medicine. B. Schmidt, B.J. Thompson, A. Chang. Oakland University William Beaumont School of Medicine. E71 582.2 Physical Models Dominate: The Pirate Patch Study. L.K. Wolak, G.A. Pukas, Y. Zheng, G.R. Norman, S.D. Monteiro, B.C. Wainman. McMaster University, Canada. E72 582.3 Revolutionizing Musculoskeletal Anatomy Teaching with Microvids-Guidelines: A Pilot Study. F.A. Huber, L. Hirtler, F.M. Kainberger. Medical University of Vienna, Austria. E73 582.4 Learning with Concept Maps and Evaluation of Individually Prepared Concept Maps Versus Concept Maps Prepared in Groups. M.K. Anand. Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India.
SUNDAY ANATOMY E74 582.5 Student Generated Structure Lists: Bringing Self-Directed Learning Into the Anatomy Laboratory. S.M. Dunham. Indiana University. E75 582.6 A Homemade Model That Helps Students Visualize Inguinal Canal Embryology, Anatomy, and Pathology. C. Pittack. Bastyr University. E76 582.7 Teach & Learn in Histology: An Old Approach Revisited. J. Iskandar, I. Hajj Hussein. OUWB School of Medicine. E77 582.8 Learning the Cardiovascular System Can Be PhUn. A.J. Gonzalez, M.E. Velez. Texas A&M- Kingsville. E78 582.9 Weaving the Human Body—An Innovative Pedagogical Proposal for the Visually Impaired/The Human Body and Modern Risks—Itinerant Museum of Anatomy 2 (IMA 2): Drugs. T.S. Masuko, J.O. GonÇalves, R.V. dos Santos’ Coutinho, H.H. da’Silva-Lima, P.d. ‘da SilvaCarvalho, J. ‘Nascimento-Santos, C.A C. Baptista. UFBA—Federal University of Bahia, Brazil and University of Toledo. E79 582.10 Teaching the Brachial Plexus to Medical Students in a Humane and Useful Way. D.A. Cotanche. University of Illinois at Chicago College of Medicine. E80 582.11 Effectiveness of Computer Assisted Learning in Anatomy and Physiology. N.T. Hilvano. University of Cincinnati Clermont. E81 582.12 Case-Based Learning Using Cadaveric Pathology Specimens Enhances Learner Engagement in Reviewing Normal Anatomy. M. Moon, D. O’Donoghue, F. Miller, K. Klump, N. Halliday. OU College of Medicine and College of Medicine. E82 582.13 Using Flipped Model and Drawing Tutorials to Teach Neuroanatomy in Graduate Certificate Program in Intraoperative Neuromonitoring. R. Filipovic, P. Andalib. University of Connecticut. E83 582.14 Enhancing Anatomy Learning by Combining Body Painting, Ultrasound, Clinical Investigation and PeerTeaching. L. Filgueira, E. Eppler. University of Fribourg, Switzerland, University of Zurich, Switzerland and University of Basel, Switzerland. E84 582.15 Impact of Team-Based Virtual Microscopy on Student Learning in Histology. P. Potaliya, S.G. Dixit, S. Ghatak. All India Institute of Medical Sciences, India and All India Institute of Medical Science, India. E85 582.16 A Crossover Randomized Controlled Trial to Evaluate the Use of Animations and Interactivity in Anatomy and Physiology Education. H. Chen, M. Ng, A. Kirubarajan, K. Kuo, A.K. Ball, I. Bayer, P.B. Helli, B.C. Wainman. McMaster University, Canada. E86 582.17 Examination of Active Learning by Sketching on the Academic Performance of Students Studying Embryology. A. Hryniuk. Augusta University. E87 582.18 Withdrawn. E88 582.19 “An Unexamined Life Is Not Worth Living”: Using Digital Journals to Promote Reflection in the Classroom. A.F. Doubleday, M.D. Strotman. University of Illinois at Chicago. E89 582.20 Anato-Olympics: Can Group Based Competition Activity Among Undergraduate Students Improve Their Performance on the Real-Time Restricted-Practical Evaluation. H. Carrero, E.H. Monroig, J.A. Solivan, M.V. Duprey-Diaz. University of Puerto Rico-Rio Piedras Campus.
E90 582.21 Tutor Group Assessments (TGAs): Criteria Based Monitoring of Medical Student Performance, Participation and Behavior in Small (Tutor) Group Sessions in a Problem Based Learning Curriculum. N.S. Viscomi, L.F. DiLalla, N. Henry, R.W. Clough. Southern Illinois University School Medicine. E91 582.22 Training of Near-Peer Tutors in the Gross Anatomy Laboratory. S.D. Hunter, D. O’Donoghue, F. Miller, N. Halliday. University of Oklahoma Health Sciences Center. E92 582.23 Improved Medical Student Perception of Ultrasound Using a Paired Anatomy Teaching Assistant and Clinical Instructor Model. J. Smith, J. Kendall, D. Royer. University of Colorado School of Medicine. E93 582.24 Innovations in Musculoskeletal Anatomy Education: Clinically Based Near-Peer and Reciprocal Peer-Teaching. W. Lackey-Cornelison. Western Michigan University and Homer Stryker MD School of Medicine. E94 582.25 Using a Dissection-Based Introductory Laboratory Video to Reduce the Anxiety State of Dissectionand Prosection-Based Anatomy Students Prior to Their First Cadaver-Based Laboratory Experience. W. Albabish, G. Newton, L. Jadeski. University of Guelph, Canada. E95 582.26 Approaches to Study and Preferred Learning Environments of First Year Medical Students in an Anatomy Course. P. Reves, K. Thompson, A. Notebaert. University of Mississippi Medical Center and Millsaps College. E96 582.27 Clinical Anatomy and Imaging Lab: Vertical Integration in a Preclinical Reproductive Organ Systems Course. M. Hankin, H. Hoops, P. Mclaren, S. Hecht, D. Stadler, M. O’Reilly. Oregon Health and Science University.
583. ANATOMY EDUCATION: CURRICULUM DESIGN AND EFFECTIVENESS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E97 583.1 Essential Anatomy in Undergraduate Medical Curricula: Orthopedics and Obstetrics and Gynecology. M. Hankin, A. Aschmetat, I. Niculescu. Oregon Health and Science University, William Beaumont Hospital and Oakland University William Beaumont School of Medicine. E98 583.2 Histology Education in the Next Generation. P.A. Shaw, M. Hernandez. Icahn School of Medicine at Mount Sinai. E99 583.3 Evaluation of Objectives-Based Learning Outcomes in a Compressed Presentation of Human Structure. K.E. Klump, M. Moon, F. Miller, D.L. O’Donoghue, N. Halliday. University of Oklahoma Health Sciences Center. E100 583.4 Teaching Anatomy to Meet the CanMEDs Competencies. C. Krebs, B. Wainman. University of British Columbia, Canada and McMaster University, Canada. E101 583.5 The Ob-Gyn and Women’s Health Selective Pathway for Senior Medical Students: The Clinical Pelvic Anatomy Laboratory Course. F. Nausheen, F. Nausheen, S. Wong, G. Valenzuela, R. Suskind, A. Tenore, L. Castro. California University of Science and Medicine, School of Medicine, Arrowhead Regional Medical Center.
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ANATOMY SUNDAY E102 583.6 Evaluation of Curricular Factors That Impact Residency Specialty Choice. L. Kim, C.A. Nichols, A.C. Edmondson. Medical College of Georgia at Augusta University. E103 583.7 Integration of the Educators: Training Program to Bridge the Foundational-Clinical Science Divide in Medical Training. A.C. Zumwalt, M. Dominguez. Boston University School of Medicine. E104 583.8 Development of a Model for Evidence Based Integration of Anatomy Into a Competency Based Undergraduate Medical Education Curriculum. M.E. Norris, M.I. Johnson, K.A. Rogers, C.M. Martin. The University of Western Ontario, Canada. E105 583.9 Development of the Summer Anatomy Enrichment Program for Rising Second Year Medical Students. E.L. Giannaris. University of Massachusetts Medical School. E106 583.10 Keeping Traditions? Perceptions of Anatomy’s Relevance to Clinical Training and Practice Across Successive Cohorts of Graduating MD Students in a New Medical Program. O. Oyedele. University of British Columbia Okanagan, Canada. E107 583.11 Anatomical Knowledge Retention in Changing Curricula. A.N. Lean, J. Lee, E. Goldman, G. Butera, K. Brown, R.A. Jurjus. The George Washington University School of Medicine. E108 583.12 Creating a Master List of Neuroscience Topics for Pre-Clinical Medical Education. D. Gould, G. Patino, V. Osula. OUWB. E109 583.13 Vertical Integration of Anatomy: Achieving the Desired Outcomes? M.D. Lazarus, A. Rascoe, D. Anderson, K. Black. Monash University, Australia, Case Western Reserve University, Strong Memorial Hospital and Penn State University. E110 583.14 Integrated Histology and Pathology Education in the Renewed UBC M.D. Undergraduate Program. K. Pinder, M. Nimmo, D. Cooper, M. Allard, H. Yule, S. Maurice. University of British Columbia, Canada. E111 583.15 Creating Milestones and Exit Competencies for Medical School Education in Histology. K. Pinder, J. Ford. The University of British Columbia, Canada and Sidra Medical and Research Center, Qatar.
584. ANATOMY EDUCATION: ONLINE AND E-LEARNING MODULES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E112 584.1 Production and Qualitative Analysis on Histology Assessment Application for Online and Mobile Learning. B.E. Culleen, L.M. Lee. University of Colorado. E113 584.2 Using Assessment to Promote Deep and Active Learning in an Online Anatomy Course. K. Kolomitro, L.W. MacKenzie. Queen’s University, Canada.
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E114 584.3 Telequantum Medical Education: Developing Teleportation, Telecommunication and Tele Emotion Skills During Basic Science Curriculum to Train Medical Students Current and Future Telemedicine Healthcare. W.W. Chen, B. Benninger. Western University of Health Sciences COMP-Northwest. E115 584.4 Directions Toward an Open-Access, University of Michigan Anatomy Website Through BlueLink Anatomical Learning Tools. K. Alsup, G.M. Fox. University of Michigan. E116 584.5 Small Group Self-Directed Learning Exercises Using a Cloud-Based Interactive Website Facilitates Application of Histology to Pathological Diagnosis. H. Ressetar, B. Palmer. West Virginia University School of Medicine. E117 584.6 Impact of Integrating Interactive Neuroanatomy e-Learning Resources on Novice Student Learning. L. Allen, R. Eagleson, S. deRibaupierre. Western University, Canada. E118 584.7 Using Interactive Online Learning Modules in Histology to Improve Long-Term Retention and Efficiency of Learning. R.L. Russell, P. Luna, D.E. Chico. Texas A&M University. E119 584.8 The Long-Term Effectiveness of Online Learning Modules for the Study of Anatomy. B. Aziz, V. Lee. TTUHSC.
585. CARDIOVASCULAR BIOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Biology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E120 585.1 Visualizing Human Embryonic Development of the Heart’s Outflow Tract. C.A. Sidorowych, L. Lebowicz, J. Daugherty, K. Brennan, D. Cotanche, C. Ross, S. Bond. University of Illinois at Chicago and University of Chicago. E121 585.2 Quantification of Structural Heterogeneities Within the Human Left Atrium Throughout the Lifespan. J.A. Sakowski, M.I. Hurley, M.P. Olivieri, M.E. Gervasi, M.F. Swartz. D’Youville College and University of Rochester Medical Center. E122 585.3 Quantification of Potassium Ion Channel Transcripts Within the Human Left Atrium Throughout the Lifespan. J.A. Coello, M.I. Hurley, M.P. Olivieri, M.E. Gervasi, M.F. Swartz. D’Youville College and University of Rochester Medical Center. E123 585.4 A Comparison of Atherosclerotic Lesion Severity in the Carotid Bulb Versus Coronary Arteries. A.B. Lawson, W.P. Newman, G. Rae. Louisiana State University Health Sciences Center (LSUHSC). E124 585.5 Morphology and Morphometric Analysis of Right and Left Coronary Arteries in Human Cadaveric Hearts. S.V. Sarangapani, S. Subramaniam. SRM Medical College and Hosppital and Research Centre, India. E125 585.6 Rare Variant of the Great Cardiac Vein. A Case Report. E. Dăescu, A. Enache, D. Sztika, D.E. Zahoi. University of Medicine and Pharmacy Victor Babe?, Romania.
SUNDAY ANATOMY E126 585.7 Double Superior Vena Cava: A Cadaveric Case Report. M.P. McGuinness. Philadelphia College of Osteopathic Medicine. E127 585.8 Visualization of Differential Myelinated Cardiac Plexus Fiber Innervation in Heart Failure Using the Sihler’s Stain Technique. A. Hilton, A. Jorgensen, B. Gardiner, S. Robison, H. Lambert, D. Morton, J. Wisco. Brigham Young University, Wake Forest University, West Virginia University and University of Utah. E128 585.9 CABG in a Cadaver: A Case Report and Review of the Literature. Gardner. BGSU Firelands. E129 585.10 Morphological Analysis of Bronchial Arteries and Variants with Computed Tomography Angiography, and Its Relevance in the Treatment of Massive Hemoptysis. R.E. Elizondo Omaña, C.N. Esparza Hernandez, J.M. Ramirez Gonzalez, R.A. Cuellar Lozano, C.S. Gonzalez Arocha, B. Martínez Gonzalez, R. Pinales Razo, G. Elizondo Riojas, S. Guzmán López. Universidad Autónoma de Nuevo León, Mexico. E130 585.11 Geometric Morphometric Comparison of Retinal Veins Between Healthy Individuals and Individuals Diagnosed with Glaucoma and Diabetic Retinopathy. A.W. Koons, M.J. Zdilla. West Liberty University. E131 585.12 Remodelling of the Atrioventricular Canal Myocardium Determines Atrioventricular Conduction Patterns. O. Nanka, R. Vicente-Steijn, N.A. Blom, M.R. Jongbloed, D. Sedmera. Charles University, First Faculty of Medicine, Czech Republic, Leiden University Medical Center, Netherlands and Czech Academy of Sciences, Czech Republic. E132 585.13 The Nkx2.5 Mutation Affects Impulse Conduction of Developing Heart. V. Olejnickova, P. Hamor, A. Kvasilova, D. Sedmera. First Faculty of Medicine, Charles University, Czech Republic, Academy of Sciences of the Czech Republic, Czech Republic and Academy of Sciences of the Czech Republic, Czech Republic. E133 585.14 Development of the Cardiac Conduction System in the Selected Groups of Reptiles as Determined by HNK-1 Expression. A. Kvasilova, M. Gregorovicova, D. Sedmera. First Faculty of Medicine, Czech Republic and The Czech Academy of Sciences, Czech Republic. E134 585.15 Anatomy of the Aortic Arctic Branches and Visceral Collars of the Abdominal Aorta of the Night Monkey (Aotus sp) C.F. Silva, E.F. Sena, S.S. Júnior, C.S. Bortolini, M.J. Bortolini, Y.K. Carvalho, R.P. Silva. Federal University of Acre, Brazil. E135 585.16 The Effect of a Soft-Embalming Solution on the Histological Structure of Porcine Cerebral Vasculature. J. Rockarts, T. Li, S. Pang, L. MacKenzie. Queens University, Canada.
586. CARDIOVASCULAR BIOLOGY: DEVELOPMENT, GROWTH AND DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Biology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E136 586.1 Ciona as a Simple Chordate Model for Heart Development and Regeneration. H. Evans Anderson. Winthrop University. E137 586.2 Cautery Injury Response in the Zebrafish Heart. N. Hockaden, N. Pillai, P.J. Lafontant. DePauw University. E138 586.3 Functional Characterization of stap2b in Zebrafish Vascular Development. Y. Wang, C. Wu. National Sun Yat-sen University, Taiwan, Department of Biological Sciences, National Sun Yat-sen University and Taiwan, Taiwan. E139 586.4 Coral-Derived Natural Marine Compound GB9 Inhibits Vascular Development in Zebrafish. Y. Song, C. Wu. National Sun Yat-sen University, Taiwan. E140 586.5 Metastatic Cancer Cells and Endothelial Cells Show Increased Expression of Transforming Growth Factor (TGF) Beta Receptors Related to Angiogenesis. J. Hawker, I. Duffy. South Florida State College and Saint Leo University. E141 586.6 Loss of lnx1 Impairs Vascular Development Mediated by Reduction of VEGF/ERK and BMP Signalings. Z. Chen, C. Wu. National Sun Yat-sen University, Taiwan. E142 586.7 The Morphological Mapping of Mesenteric Lymphatic Network. I.T. Nizamutdinova, C.A. Davis, M.R. Moreno, D.C. Zawieja. Texas A&M Health Science Center and Texas A&M University. E143 586.8 Kv1.1 Potassium Channel Deficiency Prolongs Ventricular Action Potentials and Decreases Tachycardia Susceptibility. K. Trosclair, M. Si, M. Watts, P. Dominic, K. Hamilton, E. Glasscock. Louisiana State University Health Science Center. E144 586.9 Chronic Heart Rate Reduction by Ivabradine Does Not Modify the Elastic Fiber Content in Post-Myocardial Infarction Scar of Middle-Aged Rats. E.I. Dedkov, R.J. Tomanek. Cooper Medical School of Rowan University and University of Iowa Carver College of Medicine. E145 586.10 Evaluation of Toxicological Properties of Toad Parotid Gland Extract on Heart of Adult Male Wistar Rat. C. Ihentuge, G. Ndukwe, F. Akpuaka, H. Okechukwu. Abia State University, Nigeria, Howard University, and IMO State University, Nigeria. E146 586.11 Gender Differences in Adiposity and Its Relationship to Cardiometabolic Profiles and Proinflammatory Adipokines in Spinal Cord Injury. G.J. Farkas, A.S. Gorgey, D. Dolbow, A.S. Berg, D.R. Gater. Penn State College of Medicine, Hunter Holmes McGuire VA Medical Center and University of Southern Mississippi. E147 586.12 Contribution of Macrophages to Myxomatous Valve Disease. A. Hulin, S. Potter, A. Kim, T. DeFalco, K. Yutzey. CCHMC. E148 586.13 Ventricular Growth and Coronary Vessel Development in the Giant Danio (Devario aequipinnatus) Heart. O. Shifatu, S. Glasshagel, P. Patel, H. Nelson, W. Tomamichel, C. Higginbotham, P.J. Lafontant. DePauw University.
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Biochemistry and Molecular Biology 587. UNDERGRADUATE EDUCATION (ASBMB) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B1 587.1 A Multiweek Tyrosinase Inhibitor Synthesis and Analysis Project: A Capstone Experiment for the Undergraduate Biochemistry Laboratory Course. P.S. Mertz, C.N. Streu, R.D. Reif, K.Y. Neiles, A.J. Schech. St. Mary’s College of Maryland, Albion College and University of Mary Washington. B2 587.2 Research and Writing to Promote Critical Thinking in Undergraduate Education. R.P. Rogers. Wentworth Institute of Technology. B3 587.3 Development of Learning Progressions Through the Chemistry Curriculum to Biochemistry. A.J. Wolfson, A.M. Mercer, E.G. Offerdahl, J.E. Lewis. Wellesley College, University of South Florida and Washington State University. B4 587.4 Improving STEM Student Retention via Early Research Engagement: A Pilot. P.G. Bouyer, M. Watters. Valparaiso University. B5 587.5 Teaching Chemical Biology at a Primarily Undergraduate Institution. A.M. Danowitz. Mercyhurst University. B6 587.6 Using an Alternate Reality Learning Experience (ARLE) to Teach Molecular Biology Techniques and Concepts in a Genetics Laboratory. C.L. Clauson-Kozina, J.D. Borden, S. Rheinschmidt, G. Kunzweiler. Saint Leo University. B7 587.7 Understanding the Phenomenological and Ontological Identity of the Black Seminole in Southwest Texas as a Means for Historical Preservation and Formation of a Community Narrative. P. Torres, M. Trevino, B. Villasenor, K. Pena, G. Villareal, D. Rincon, I. Vasquez, J. Barrera, J. Verastegui, N. Carrillo, C. Williams, R. Escamilla, R. Pena, C. De La Cerda, J. Porras, E. Ramirez, J. Riojas, V. Williams, D. Johnson; Jr. Southwest Texas Junior College. B8 587.8 what the Biochemistry Education Research Literature Can Tell University-Level Biochemistry Instructors. F.K. Lang, G.M. Bodner. Purdue University. B9 587.9 Integration of Literature-Based Activities to Enhance the Learning of Content, Scientific Process, and Quantitative Analysis in Biochemistry Courses. H. Masuda. Indiana University Kokomo. B10 587.10 Teaching Cell Signaling Through Research: The Freshman Research Initiative at the University of Texas at Austin. G. Clark, S. Rodenbusch, S. Roux. University of Texas at Austin. B11 587.11 Execution and Assessment of a Mindset Intervention in an Introductory Biochemistry Class. D.J. Hall. Lawrence University. B12 587.12 Introduction of Enzymatic Polymer Degradation to Enhance the Undergraduate Polymer Chemistry Curriculum. A.E. Neely, N.Y. Davis, M.H. Weiland. Armstrong State University.
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B13 587.13 Northwest Biosciences Consortium RCN-UBE: Organization and Development of a Faculty Network Leadership Team. A. Kruchten, E. Baumgartner, A. Beadles-Bohling, J. Brown, J. Duncan, L. Kayes, S. Kiser, S. Seidel, W. Shriner, S. Stavrianeas, C. Tillberg. The College of Saint Scholastica, Western Oregon University, University of Portland, Linfield College, Willamette University, Oregon State University, Lane Community College, Pacific Lutheran University and Mount Hood Community College. B14 587.14 Investigating Variations in Instructor-Generated Feedback as a Mediating Factor for Student Learning. E. Offerdahl, J. Boyer, M. McConnell, J. Momsen, R. Salter, K. Williams, L. Wiltbank. Washington State University and North Dakota State University. B15 587.15 Phylogenetic Analysis of RuBIsCO: An Active Learning Strategy for Teaching Plant Evolution. M. Van Stry. Lane College. B530 631.2 Stressing Interdisciplinarity to Mold the Undergraduate Experience. C.M. Keller, B.E. Bridges, J.N. Roney, D.R. Dries. Juniata College.
588. LEARNING TOOLS IN MOLECULAR BIOLOGY AND BIOCHEMISTRY UNDERGRADUATE EDUCATION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B16 588.1 A Process for Defining and Validating Learning Competencies for Course-Based Undergraduate Research Experiences in a Biochemistry Laboratory Course. S.M. Irby, N.J. Pelaez, T.R. Anderson. Purdue University. B17 588.2 A Model for a Scientific Literature and Data Analysis Driven Undergraduate Course. K.K. Resendes. Westminster College. B18 588.3 Improving Student Understanding of PreRequisite Knowledge and Long Term Understanding of Biochemical Concepts. A.T. Taylor, W.R. Novak. Wabash College. B19 588.4 Transition to a Course-Based Undergraduate Research Experience (CURE) P.A. Craig, J.L. Mills, R. Roberts, M. Pikaart, C. Daubner, S. Irby, T. Anderson. Rochester Institute of Technology, Ursinus College, Hope College, St. Mary’s University and Purdue University. B20 588.5 How Four Research Scientists Integrate Methods, Mechanisms, Context, Analogies, and Theory to Communicate Explanations About Protein Folding and Dynamics. K.A. Jeffery, N. Pelaez, T.R. Anderson. Purdue University. B21 588.6 Computational Studies of the Nudix Hydrolase Superfamily and Nitrophenyl Phosphatase Subfamily of the Had Superfamily. K. O’Donovan, J. Nulsen, P. Craig, S. O’Handley. Rochester Institute of Technology.
SUNDAY BIOCHEMISTRY B22 588.7 Variation in the Effectiveness of Clicker Use Based on Cohort Composition in a Small Upper Division Cell and Molecular Biology Course. K.K. Resendes. Westminster College. B23 588.8 Experiences of Undergraduate Students Identifying Proteins of Unknown Function as Part of a Teaching Laboratory in a Biochemistry Course. S. Daubner, J. Beckman, J. Beltran Gastelum, S. Mallet, E. Vogt. St. Mary’s University. B24 588.9 A Framework for Assessing Molecular Visualization Skills and Competencies. D.R. Dries, P.A. Craig, D. Dean, H.V. Jakubowski, W.R. Novak, A.I. Roca, C.R. Terrell, M.A. Franzen. Juniata College, Rochester Institute of Technology, University of Saint Joseph, College of St. Benedict/St. John’s University, Wabash College, ProfileGrid. org, University of Minnesota, Rochester and Milwaukee School of Engineering. B25 588.10 Assigning and Testing Function from Structure of Uncharacterized Proteins. M. Pikaart, S. Bettag, M. Cunningham, C. Da Silva, C. Gager, M. Glover, K. Jacobs, L. Kennington, J. Knol, N. Ladd, K. Mader, M.M. Magan, Y. Mao, E. Marinelli, L. Miller, R. Nickels, S. Ratliff, A. Rhodes, C. Schaar, M. Turner. Hope College. B26 588.11 Glutamic Acid 446 and Arginine 447 in Heat Shock Protein 70 (hsp70) Are Critical for Regulating Superoxide Dismutase-2 (SOD2) Function. A.J. Afolayan, R.J. Teng, G.G. Konduri. Medical College of Wisconsin. B27 588.12 Modeling Interdisciplinary Collaborations Through a Course-Based Undergraduate Research Experience (CURE) R. Roberts, J. Koeppe, S. Price, B. Allwein, T. Anderson, S. Daubner, S. Irby, J. Mills, M. Pikaart, P. Craig. Ursinus College, SUNY College at Oswego, Purdue University, St Mary’s University San Antonio, Rochester Institute of Technology and Hope College. B28 588.13 Assessing Learning Gains Through ePortfolios in an Undergraduate Biochemistry Lab. J.L. Mills, A. DiCola, R. Roberts, M. Pikaart, C. Daubner, S. Irby, T. Anderson, H.J. Bernstein, P.A. Craig. RIT, Ursinus College, Hope College, St. Mary’s University and Purdue University.
589. EXPANDING UNDERGRADUATE RESEARCH OPPORTUNITIES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B29 589.1 Approaching Undergraduate Research with Students Who Are Deaf and Hard of Hearing. A.U. Gehret, J.W. Trussell, L.V. Michel. National Technical Institute for the Deaf/Rochester Institute of Technology and Rochester Institute of Technology. B30 589.2 Examining the Research Experiences of Undergraduate Biochemistry Students: A Case Study Approach. S.L. Johnson, G.M. Bodner. Purdue University. B31 589.3 Rheostat or Toggle: Examining the Role of Non-Conserved Mutations to LURE Students Into Research. A.K. Ayella, B.R. Moriah. McPherson College and Wichita State University.
B32 589.4 Successes and Teachable Moments During a Partnership to Create a Research-Like Experience in a 2 Year College Organic Chemistry II Laboratory. N. Jaco, C. Lutz, J. Grant. University of Wisconsin-Stout and Anoka-Ramsey Community College. B33 589.5 Integrating Human Cell Culture Into Undergraduate Research Projects. C.E. Taylor. Mercyhurst University. B34 589.6 CRISPR in the Undergraduate Classroom: A CURE. H.J. Evans Anderson. Winthrop University. B35 589.7 The Council on Undergraduate Research (CUR): What’s in It for Post-Docs and New Faculty? Advancing Your Research Career with/Through the Council on Undergraduate Research. M. Wolyniak, L. Wimmers. Hampden-Sydney College and Towson University. B36 589.8 Year-Long Research Experiences in Drug Discovery May Lead to Positive Outcomes for Transfer Students. J. Beckham, L. Strong. The University of Texas at Austin.
590. EXPERIMENTAL BIOLOGY AND MEDICINE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B37 590.1 Live Cell Microscopy of Intestinal Organoid Oxygenation. R.I. Dmitriev, I.A. Okkelman, T. Foley, D.B. Papkovsky. University College Cork, Ireland. B38 590.2 Quantitative Multi-Parametric Microscopy Analysis of Live 3D Cell Models. R.I. Dmitriev, J. Jenkins, I.A. Okkelman, N. O’Donnell. University College Cork, Ireland. B39 590.3 Full-Thickness Engineered Skin Tissue with 3D Biomimetic Micro-Topography. J. Yu, E. Korkmaz, P. LeDuc, B. Ozdoganlar. Carnegie Mellon University. B40 590.4 An Integrated Biomimetic Adipose Tissue Microchip. Y. Chen, L. Ramalingam, J. Wu, N. MoustaidMoussa, W. Li. Wuhan Institute of Technology, People’s Republic of China, and Texas Tech University. B41 590.5 Dried Plums Modify the Colon Luminal Metabolome in a Rat Model of Colon Carcinogenesis. D.V. Seidel, S.S. Taddeo, M.A. Azcarate-Peril, R.J. Carroll, N.D. Turner. Texas A&M University and University of North Carolina School of Medicine. B42 590.6 Bisphenol-A and 17-β Estradiol Alter Colon Microbial Metabolites and Exacerbate Dextran Sodium SulfateInduced Colitis in Mice. J.A. DeLuca, R. Menon, R. Riordan, K.F. Allred, A. Jayaraman, C.D. Allred. Texas A&M University.
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591. GENOME DYNAMICS: DNA REPLICATION, REPAIR AND RECOMBINATION Poster
Poster
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:00 pm–2:30 pm
Presentation time: 12:00 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
B43 591.1 DDI1- and DDI2-Dependent Removal of Replication Termination Factor Domain Containing 1 (RTFDC1) from Replication Forks Is Necessary for Proper Response to Replication Stress. M.C. Kottemann, B. Conti, F.P. Lach, A. Smogorzewska. The Rockefeller University. B44 591.2 Investigating the Regulation of recA in the Emerging Pathogen Acinetobacter baumannii C. Ching, K. Gozzi, B. Heinemann, V.G. Godoy. Northeastern University. B45 591.3 Escherichia coli DinB and ReplicationTranscription Collisions. T. Tashjian, J.A. Halliday, C. Herman, V. Godoy. Northeastern University and Baylor College of Medicine. B46 591.4 Genetic and Environmental Factors That Regulate Tandem Repeat Variation in Coding Regions. S.M. Fuchs. Tufts University and Allen Discovery Center at Tufts. B47 591.5 The Effects of Replication Fork Restart on CAG Repeat Instability in S. pombe M. Gold, K. Freon, A. Su, S. Lambert, C. Freudenreich. Tufts University and Curie Institute, France. B48 591.6 Potent DNA Strand Annealing Mediated by the T7 Single-Stranded DNA Binding Protein gp2.5 A.J. Hernandez, C.C. Richardson. Harvard Medical School. B49 591.7 The Replication Factor A2 N-Terminus Is Required for Proper Progression Through Meiotic Divisions. A. Adsero, T. Wilson, S. Haring. North Dakota State University. B50 591.8 Structure and Mechanism of a Viral Genome Packaging Motor. B. Kelch. University of Massachusetts Medical School. B51 591.9 Mutagenesis of HEK293 Cells Reveals Phenotypic and Genotypic Variants Involved in Hsp90Mediated Glucocorticoid Signaling. T.M. Forst, S.M. Ryan, N. Pelle, P.J M. Murphy. Seattle University. B52 591.10 Genetic Variations at 15 Forensically Relevant Microsatellite Loci (STRs) in the Three Major Ethno-Linguistic Population Groups in Nigeria. B.U. Agbo, O.A T. Ebuehi, A.A. Osuntoki. University of Lagos, Nigeria.
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592. DNA POLYMERASES, REPLICASES AND REPLISOMES
B53 592.1 Role of the Excluded Strand in DNA Unwinding by Hexameric Helicases. M. Trakselis. Baylor University. B54 592.2 Y-Family DNA Polymerase Human Pol Kappa Is More Tolerant of Changes to Its Active Site Loop Than DinB. N.M. Antczak, M. Packer, J. Walsh, P. Ippoliti, P.J. Beuning. Northeastern University. B55 592.3 Residues of Escherichia coli Thioredoxin Critical for Interaction with Phage T7 DNA Polymerase to Increase Processivity. S. Lee, N. Tran, C.C. Richardson. Harvard Medical School. B56 592.4 Dynamics of the E. coli Beta Clamp and Its Influence on DNA Loading. B. Koleva, J. Baez, J. Conway, A. Wu, P. Beuning. Northeastern University and Colgate University. B57 592.5 Understanding Conformational Changes During Translesion Synthesis: In Silico Studies of DinB. E. Perez, B. Sampoli Benitez. Marymount Manhattan College. B58 592.6 Role of Pol κ and DinB Distal Residues on Extension Step of TLS. H.R. Stern, C.L. Mills, M.J. Ondrechen, P.J. Beuning. Northeastern University. B59 592.7 The Epsilon Subunit of DNA Polymerase III in the Bacterial Response to Quinolones. Z. Whatley, N. Sy, S. DiDomenico, A. Finck. Gettysburg College. B60 592.8 Investigating the Mechanism of Trans-Lesion Synthesis by Human DNA Polymerase Kappa. T.B. Allen, Z. Younger, B. Sampoli Benitez. Marymount Manhattan College. B61 592.9 Role of Exo1 Nuclease in Telomere DNA Degradation in yku70/yku80 Mutants of S. cerevisiae J.A. Ream, L.K. Lewis. Texas State University. B62 592.10 Inflammation, Global DNA Methylation and Telomeres in Healthy Adolescents. Y. Dong, Y. Huang, B. Gutin, Y. Dong, H. Zhu. Medical College of Georgia.
SUNDAY BIOCHEMISTRY
593. CHROMATIN STRUCTURE AND GENE EXPRESSION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B63 593.1 Interactions Between Variant Histone H2A.Z and Linker Histone H1 in Budding Yeast. J. Riggs, J. Huang, L. Winston, M. Sica, S. Holmes. Wesleyan University. B64 593.2 Epigenetics and Gene Expression—Pathways, Pathway Suites and Networks at RGD’s Pathway Portal. V. Petri, G. Hayman, J.R. Smith, M. Tutaj, J. Thota, J. De Pons, M.R. Dwinell, M. Shimoyama. Medical College of Wisconsin. B65 593.3 Decipher and Target Cancer Cell Dependency on Epigenetic Mutations. G. Wang. University of North Carolina at Chapel Hill. B66 593.4 Epigenetic Manipulation of Inactive X Chromosome for Rett Syndrome Therapeutics. S. Bhatnagar. University of Virginia School of Medicine. B67 593.5 L3MBTL2 Is Required for Spermatogenesis and the Maintenance of Male Fertility. C. Meng. The Chinese University of Hong Kong, People’s Republic of China. B68 593.6 Role of Chromatin Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination Mediated Gene Silencing. H. Wang, Z. Zhang, A.E. Jones, M.B. Renfrow, C. Liu, W. An, J. Luo, W. Wu, Y. Kang, Y. Tong. University of Alabama at Birmingham, Nanyang Technological University, Singapore, University of Southern California, Chinese Academy of Sciences, People’s Republic of China, and University of Toronto, Canada. B69 593.7 Interaction of Protein Occupancy, Chromosome Structure, and Gene Regulation in E. coli G.M. Kroner, S. Scholz, T.J. Goss, X. Lin, P.L. Freddolino. University of Michigan. B70 593.8 The Role of CCCTC Binding Factor (CTCF) in Epithelial to Mesenchymal Transition (EMT) A. Bhattacharya, J. Hur, A. Dhasarathy. UND School of Medicine and Health Sciences. B71 593.9 Toward the Molecular Identification of Afr2, a Gene Implicated in Liver Cancer. Z. Grimes, R. SeipeltThiemann, M. Paterson, B. Spear. Middle Tennessee State University and University of Kentucky. B72 593.10 Chromatin Accessibility of the Dosage Compensated Drosophila Male X-Chromosome Is Established by a Context-Specific Role for the CLAMP Zinc Finger Protein. E. Larschan, J. Urban, G. Kuzu. Brown University. B73 593.11 Argonaute2 Cooperates with Laminb to Repress Transcription at Lamin-Associated Domains in Drosophila melanogaster E. Nazer, M. Chinen, R. Dale, E. Lei. National Institute of Diabetes and Digestive and Kidney Diseases and National Institutes of Health.
B74 593.12 Role of the ELL Complex in Transcriptional Regulation in S. pombe S. Gopalan, D. Gibbon, C. Seidel, Y. Zhang, L. Florens, M. Washburn, J. Conaway, R. Conaway. Stowers Institute and University of Kansas Medical Center. B75 593.13 Characterization of the SUN Domain Protein Mps3 Function in Gene Expression. L. Antoniacci, R. Lukasak. Marywood University and Marywood Univeristy. B76 593.14 INO80 Chromatin Remodeling Connects Metabolic Gene Expression to Cell Division. A.J. Morrison, G. Gowans, A. Schep, D. King, W. Greenleaf. Stanford University. B77 593.15 An Epigenetic Switch Regulates de Novo DNA Methylation at Pluripotency Gene Enhancers. H. Gowher, C.J. Petell. Purdue University. B78 593.16 Biochemical Insights Into the Mechanism of Oncohistones. P.W. Lewis. University of Wisconsin-Madison. B79 593.17 Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation. S.R. Bhaumik, R. Sen, J. Ferdoush, A. Kaja. Southern Illinois University School of Medicine.
594. CHROMATIN STRUCTURE, REMODELING AND ASSEMBLY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B80 594.1 Retention of CENP-A Nucleosomes During DNA Replication. E. Zasadzinska, J. Huang, A.O. Bailey, N.S. Lee, K.A. Wong, M.R. Jakubaszek, L. Guo, B.E. Black, D.R. Foltz. Northwestern University, University of Virginia and University of Pennsylvania. B81 594.2 Determination of Altered Bromodomain Function of Cancer-Associated Missense Mutations in Polybromo-1 C. Goetz, E. Dykhuizen, B. Smith. Medical College of Wisconsin and Purdue University. B82 594.3 Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J.K. Low, A.P. Silva, M. Sharifitabar, M. Torrado, J. Schmidberger, S.R. Webb, H. Saathoff, B.L. Parker, B. Paudel, A. van Oijen, M.J. Landsberg, N.E. Shepherd, J.P. Mackay. The University of Sydney, Australia, The University of Wollongong, Australia and The University of Queensland, Australia. B83 594.4 Roles of PARP-1-Dependent Poly(ADPRibosyl)ation in Regulation of the Catalytic Activity of Human ALC1 Chromatin Remodeling Enzyme. S. Ooi. Stowers Institute for Medical Research. B84 594.5 Complementary Roles of Pseudomonas aeruginosa Condensins in Global Chromosome Organization. B.K. Bhowmik, V.V. Rybenkov. University of Oklahoma. B85 594.6 Sequence Analysis of Mutant Chick Embryo DNA. J. Vo, J. Byk, S.R. Smith, M.A. Benore. University of Michigan Dearborn.
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595. EPIGENETIC MODIFICATIONS OF DNA AND RNA Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B97 595.1 Withdrawn. B98 595.2 Epigenetic Regulation of Alternative Developmental Trajectories. A.L. Romney, J.E. Podrabsky. Portland State University. B99 595.3 A Shared Structural Recognition Element in mRNA Substrates of the tRNA Modifying Enzyme Pseudouridine Synthase 1 T.M. Carlile, T.A. Bell, M.F. RojasDuran, B. Zinshteyn, H. Shin, C. Mason, W.V. Gilbert. MIT. B100 595.4 Epigenetic Regulation Through UHRF Proteins. S.B. Rothbart, R.M. Vaughan, E.M. Cornett, B.M. Dickson. Van Andel Research Institute. B101 595.5 Profiling of DNA Methylation Patterns in Response to Inorganic Arsenic Exposure and Reversal of Exposure. M.L. Eckstein, M. Rea, R. Eleazer, Y. FondufeMittendorf. University of Kentucky. B102 595.6 Spatio-Temporal Dynamics of Sphingosine1-Phosphate Receptor 1 Activity in Endothelial Cells During Lung Injury and Resolution. M. Akhter, D. Mehta. Department of Pharmacology, College of Medicine and University of Illinois at Chicago. B103 595.7 DNA Cytosine Methyltransferase Promotes Stationary Phase Fitness in Escherichia coli O. Kambhampati, L. Finnerty-Haggerty, R. Huss, R. Knapp, K. Militello. SUNY Geneseo. B104 595.8 Ciglitazone Prevent Inflammation in Skeletal Muscle Induced by Hyperhomocysteinemia. A. Majumder, J. Behera, S.C. Tyagi. University of Louisville. B105 595.9 Bisulfite DNA Sequencing Analyses to Detect Methylation Patterns in the P73 Gene Promoter in Prostate Cancer Cell Lines. N. Braganca, L.M. Carastro, J.J. Schabort, J.Y. Park. The University of Tampa and H. Lee Moffitt Cancer Center & Research Institute. B106 595.10 YTHDC2 Regulates Spermatogenesis Through Promoting the Translation of N6-MethyladenosineModified RNA. P.J. Hsu, Y. Zhu, H. Ma, Y. Cui, X. Shi, G. Luo, Z. Lu, H. Shi, Q. Dai, M. Clark, B. Shen, C. He. The University of Chicago, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, People’s Republic of China. B107 595.11 Free Hemoglobin Change Gene Expression Involving in Cell-Cell Signaling Through Different DNA Methylation in THP-1-Derived Macrophages. M. Cha, M. Lee. Korea Institute of Oriental Medicine, Republic of Korea.
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B108 595.12 Methylation Status of the Gene Encoding Akt2 in Cinnamon Extract Treated MCF-7 Cells. M. Hill, R. Bulko, A. Aulthouse, D. Kinder, A. Stockert. Ohio Northern University. B109 595.13 MCF-7 Morphological Changes Upon Treatment with Aqueous Cinnamon Extract. R. Bulko, R. Aljahani, A. Aulthouse, D. Kinder, A. Stockert. Ohio Northern University. B110 595.14 Combinatorial Effects of PK11195 and 5-Azacytidine as an Epigenetic Modulator for MPC1. D. Duran, R.W. O’Donnell. SUNY Geneseo. B111 595.15 Upregulating Human Leukocyte Antigen Expression in Multiple Cancer Cells Through Epigenetic Modulators. N.T. Terrigino, D.J. Nicholas, R.E. Powers, S. Dutta, R.W. O’Donnell. SUNY Geneseo. B112 595.16 DNMIi Decitabine Induces a Type I Interferon Response in Leukemia Cell Lines. D.J. Nicholas, P. Srivastava, A. AlShangity, M.J. Nemeth. SUNY Geneseo and Roswell Park Cancer Institute. B113 595.17 Deciphering the Dynamics of UHRF1Dependent DNA Methylation. R.L. Tiedemann, P.A. Jones, S.B. Rothbart. Van Andel Research Institute. B114 595.18 Investigating the Heritability of a Learned Pathogen Avoidance Behavior in Caenorhabditis elegans L.E. Meissner, G.A. Manilla, T.G. Brown, E.M. Youngman. Villanova University.
596. RNA: PROCESSING, TRANSPORT, AND REGULATORY MECHANISMS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B115 596.1 Nuclear Export Factor 3 Regulates Localization of SnoRNAs. M. Li, J. Lee, A. Sletten, K. Pyles, J. Schaffer. Washington University in St. Louis School of Medicine. B116 596.2 Nuclear Phosphoinositide Signalling Coupled Variant Poly(A) Polymerase Star-PAP Regulates Metastatic Invasion. S. Ap, R.S. Laishram. Rajiv Gandhi Centre for Biotechnology, India. B117 596.3 Withdrawn B118 596.4 The Role of mRNA Degradation in Dynamic Nitrogen Environments in Saccharomyces cerevisiae C.S. Rodriguez-Tirado, D. Gresham, F. Abdul-Rahman. University of Puerto Rico, Puerto Rico and New York University.
SUNDAY BIOCHEMISTRY B119 596.5 Potential Therapeutic Targets and Biomarkers for Seizure: Genome-Wide DE miRNA Expression Profiling of Rat Brain Following Exposure to Soman. X. Feng, A. Gautam, R. Kumar, G. Dimitrov, B. Sowe, F. Rossetti, J.L. Meyerhoff, L.A. Lumley, R. Hammamieh, M. Jett. Geneva/USACEHR, USACEHR, Walter Reed Army Institute of Research and US Army Medical Research Institute of Chemical Defense. B120 596.6 Export of Discarded, Splicing Intermediates Provides Insight Into mRNA Export. Y. Zeng, J. Staley. The University of Chicago. B121 596.7 Engineering of an Immunogenic PreTrans-Splicing RNA (iPTR) to Block Growth and Express a Glioblastoma Specific Epitope. S.C. Falotico, N. Sivetz, P. Nekrasov, M.J. Hicks. Monmouth University. B122 596.8 Unraveling the Role of Helicases in Nonfunctional rRNA Decay. V. Yu, F. LaRiviere. Washington and Lee University. B123 596.9 A Genetic Interaction Between DED1 and HAT1 in Saccharomyces cerevisiae Suggests a Role for Hat1p in Mrna Storage. A. Hilliker, A. Kindsfather, A. Winters, N. Rothbard, S. Robins, L. Fronek. University of Richmond. B124 596.10 Post-Transcriptional Modulation of aENaC mRNA Stability in Alveolar Epithelial Cells: Involvement of Conserved Domains on Its 3′ Untranslated Region. F. Gagnon, F. Migneault, Y. Berthiaume, A. Dagenais. Institut de Recherches Cliniques de Montreal, Canada. B125 596.11 Differential Alternative Splicing in Clinical Strains of Cryptococcus neoformans M.C. Merryman, E. McClelland, R. Seipelt-Thiemann. Middle Tennessee State University. B126 596.12 Dissecting the Mechanism of H3K36 Methylation in Regulating Pre-mRNA Splicing. C. Leung, S. Douglass, T. Johnson. UCLA. B127 596.13 The Role of the Essential Splicing Factor Prp2 in Ribosome Biogenesis. S. Edwards, A. Hossain, T. Johnson. University of California at Los Angeles.
597. RNA POLYMERASES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B128 597.1 P-TEFb Regulates Oocyte Maturation and Embryonic Genome Activation by Pol II CTD Phosphorylation and Ribosomal RNA Processing in Mammals. D.I. Jin, R.K. Oqani, T. Lin, J.E. Lee, S.Y. Kim. Chungnam National University, Republic of Korea.
B129 597.2 Early Elongation Control of RNA Polymerase II Transcription by TFIIS. S. Peck, M. Fox, W. Smith-Kinnaman, H. Gao, Y. Liu, A. Mosley. Indiana University School of Medicine. B130 597.3 Regulation of RNA Polymerase Translocation by the RNA and DNA Hybridization at the Upstream Edge of the Transcription Bubble. M. Kireeva, C. Trang, G. Matevosyan, L. Lubkowska, M. Kashlev. NCI. B131 597.4 PAF53 Is Essential in Mammalian Cells: CRISPR/Cas9 Fails to Eliminate PAF53 Expression. L. Rothblum, E. Chang, K. Rothblum. OUHSC.
598. RNA BINDING PROTEINS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B132 598.1 Role of Cystines in the Structure and Function of the RNA-Binding Protein LAR. P6 E.L. Peña, L.F. Lane, E. Salas, J.M. Castro, K.A. Lewis. Texas State University. B133 598.2 Alternative Splicing of hnRNPA2/B1 by SRSF2 and Its Effects on Stress Granule Formation in Myelodysplasia. A. Ardasheva, R. Vasic, S. Halene. Juniata College and Yale University School of Medicine. B134 598.3 Effect of Histidine Rich Sequence Motifs on the RNA Binding Activity of LAR. P6 C. Toner, F.C. Betancourt, K. Lewis. Texas State University. B135 598.4 Biochemical Characterization of Evolutionary Divergent Vertebrate LARP6 Proteins. J.M. Castro, D.A. Horn, K.A. Lewis. Texas State University and Agilent Technologies. B136 598.5 Insights Into HuR RRM1-2 Tandem Domains Self-Association and mRNA Recognition. A.S. Pinheiro, C. Lixa, K.A. Jendiroba, L.T. Lima, M.T. de Magalhães, F.C. Almeida. Federal University of Rio de Janeiro, Brazil and Federal University of Minas Gerais, Brazil. B137 598.6 Understanding the Role of Post-Translational Modifications on the Splicing Activity of Two Related RNA Binding Proteins. J.M. Reynaga, J. Pina, N. Keppetipola. California State University Fullerton. B138 598.7 Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTB. P1 R.J. Ontiveros, J. Doan, E. Adams, A.L. Hernandez, D.L. Black, N.M. Keppetipola. California State University, Fullerton, University of California at Los Angeles. B139 598.8 Mechanism of PWI Domain Binding to Nucleic Acids. B.R. Szymczyna, H. Chanzu, N. Jandaghijafari, E.I. Lopez, D. Flores. Western Michigan University.
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599. RNA STRUCTURE, FOLDING AND DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B140 599.1 Thermodynamic Analysis of a 4x4 Internal Loop in Magnesium Riboswitch. E. Gilbertson. Colorado College. B141 599.2 Structural Probing of the Cap-Independent Vascular Endothelial Growth Factor Messenger RNA. W. Huang, H. Scott, W. Merrick, D. Bhattacharyya, S. Basu, D. Taylor. Case Western Reserve University and Kent State University. B142 599.3 Synthesis and Characterization of Nucleic Acid Aptamers Targeted at Aspergillus Surface Carbohydrates. J.A. Bush, M. Sheridan, D.R. Engelke, C.E. Rohlman. Albion College and The University of Michigan. B143 599.4 Unique Structures in the 3’ UTR of Blackcurrant Reversion Nepovirus Genomic RNA 1 Promote Translation Initiation. L.D. Baquero-Galvis, E. Shields, M.E. Filbin-Wong. Metropolitan State University of Denver. B144 599.5 Thermodynamic Examination of the Bulged-G Motif in the 23S Ribosomal RNA. Z. Aman. Colorado College. B145 599.6 A Cellular Non-Coding RNA Activator of Human 2′-5′-Oligoadenylate Synthetase 1 B.M. Calderon, G.L. Conn. Emory University.
600. MECHANISMS AND REGULATION OF PROTEIN SYNTHESIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B146 600.1 Analysis of Eukaryotic Translation Initiation Factor (eIF) Phosphorylation by Mass Spectrometry. K. Beglinger, N. Villa, A. Andaya, J. Leary, C. Fraser. University of California at Davis. B147 600.2 Regulation of Protein Translation Initiation by Estrogen. M.K. Holz. Yeshiva University. B148 600.3 Phosphorylation of eIF2 Directs Multiple Mechanisms of Preferential Translation for Cell Adaptation to Environmental Stress. R.C. Wek, S.K. Young, J.A. Willy, M.E. Fusakio. Indiana University School of Medicine. B149 600.4 Protein Synthesis Regulation by Soy Isoflavones Metabolite Equol in Metastatic Breast Cancer Cells. A.M. Cruz-Collazo, C. de la Parra, R.J. Schneider, S.M. Dharmawardhane. University of Puerto Rico—Medical Sciences Campus, Puerto Rico and New York University School of Medicine. B150 600.5 Antimicrobial Peptide Turns the Ribosome Into a Release Factor Trap. T. Florin, C. Maracci, M. Graf, P. Karki, D. Klepacki, M.V. Rodnina, D.N. Wilson, N. Vázquez-Laslop, A.S. Mankin. University of Illinois at Chicago, Max Planck Institute for Biophysical Chemistry, Germany, University of Munich, Germany and University of Hamburg, Germany.
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B151 600.6 Mediating Protein Synthesis in Developing Neurons: Netrin Receptor Deleted in Colorectal Cancer (DCC) Binds Eukaryotic Ribosomes to Prevent Translation of Messages Independent of Initiation Mechanism. M.E. FilbinWong, T. Gonen, J.S. Kieft. Metropolitan State University of Denver, Howard Hughes Medical Institute and University of Colorado School of Medicine. B152 600.7 Characterization of CD38 mRNA, Protein, and Enzyme Activity in the Cell Types of the Heart. J. Boslett, J.L. Zweier. Ohio State University. B153 600.8 Differentiation of Human Keratinocytes Requires Translational Control by the eIF2 Kinase GCN2. A. Collier, R. Wek, D. Spandau. Indiana University School of Medicine. B154 600.9 The N-Terminus of Secis Binding Protein 2 Is Required for Processive Selenocystine Incorporation in Selenoprotein P. M.H. Pinkerton, M. Vetick, S.P. Shetty, P.R. Copeland. Rutgers University. B155 600.10 Messenger RNA Stability Drives the Expression of Antibiotic Resistance Methyltransferase Independently of Ribosome Stalling. K. Los, M. Yap. St. Louis University School of Medicine. B156 600.11 Regulation of Protein Synthesis by PostTranslational Modification of Eukaryotic Translation Elongation Factor 1A. P. Sharma, M.K. Mateyak, D. He, W.B. Perez, T.G. Kinzy. Rutgers- RWJ Medical School. B157 600.12 IL-6 Modulates Cardiac Muscle Proteostasis and Anti-Oxidative Capacity Post-Burn. A. El Ayadi, Y. Wang, A. Prasai, M. Wetzel, A. Goullry, C. Porter, D.N. Herndon, C. Finnerty. University of Texas Medical Branch and Shriners Hospital for Children. B158 600.13 Enhancement of Transgene Production in a Vaccinia Virus-Based Expression System. B. Richard, J. Flores, B. Jacobs, J. Chaput, B. Wellensiek. Midwestern University, The Biodesign Institute, Arizona State University and Arizona State University. B159 600.14 Characterization of a Short Motif Capable of Enhancing Human Cap-Independent Translation. A.N. Juba, A. Hansen, J.C. Chaput, B.P. Wellensiek. Midwestern University, The Biodesign Institute, Arizona State University and Arizona State University.
601. PROTEIN INTERACTIONS AND BINDING (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Interactions and Binding (II), Monday, Protein Interactions and Binding (III) Tuesday B160 601.1 Effect of Transient Helicity of cMyb TAD on Its Binding Affinity to the Kix Domain of CBP/p300 A. Poosapati, W. Borcherds, M.D. Carbtree, S.L. Shammas, J. Clarke, G.W. Daughdrill. University of South Florida and University of Cambridge, United Kingdom. B161 601.2 Importance of the C-Terminal Histidine Residues of Helicobacter pylori GroES for Toll-Like Receptor 4 Binding and Interleukin-8 Cytokine Production. L. Chow, H. Lee, Y. Su, B. Huang, F. Hsieh. College of Medicine and National Taiwan Univ., Taiwan.
SUNDAY BIOCHEMISTRY B162 601.3 Distinct Liver X Receptor Alpha Residues at the Protein-Protein Interface Mediate Ligand Dependent Transactivation in Heterodimeric Contexts. S. Bedi, S.D. Rider; Jr., H.A. Hostetler. Wright State University. B163 601.4 Predictive Models of Peptide RMS Fluctuations in the Context of HLA-A*2:01 Through Sequence Alone. C. Ayres, T. Riley, S. Corcelli, B. Baker. University of Notre Dame. B164 601.5 CD47 Is Required for Activation and Clustering of the TCR/CD3/ Intraflagellar Transport Complex to the Immune Synapse. A. Nugooru, S. Kaur, S.P. Singh, D.D. Roberts. National Institutes of Health, National Cancer Institute, Virginia Commonwealth University, National Institutes of Health and National Institute of Allergy and Infectious Diseases. B165 601.6 Biophysical and Structural Characterization of Antigen Recognition by the Alloreactive HCV1406 TCR. Y.M. Wang, B.M. Baker. University of Notre Dame. B166 601.7 Effect of Allosteric Changes in MERS 3CL Protease Enzymatic Activity and Dimerization. L.S. Gonzalez, B. Anson, A. Mesecar. Purdue/Truman and Purdue University. B167 601.8 Molecular Dynamics Simulations Support Multiple Binding Sites for Phospholamban on SERCA. N. Smolin, S.L. Robia. B168 601.9 Determination of the Residues Necessary for the Self-Interaction of Atg11, a Central Organizer of the Selective Autophagy Initiation Complex. Z. Spearin, H. Cawthon, J. Smith, S.K. Backues. Eastern Michigan University. B169 601.10 Investigating the Binding Affinity of the Peptide Humanin and Its Analogs to Amyloid Beta. D.E. Esckilsen, P. Guttikonda, B.W. Iwaniec, H. Evans, M.C. Milletti, D. HeylClegg. Eastern Michigan University. B170 601.11 Activation of the H-NOX Redox Sensor in Vibrio cholerae by a Zinc Ligand Switch Mechanism. R. Mukhopadhyay, E.T. Yukl. New Mexico State University. B171 601.12 Regulation of Ankyrin-Repeat and SOCSBox Protein 9 (ASB9) in Ovarian Follicles and Identification of Binding Partners. G. Benoit, J.G. Lussier, K. Ndiaye. University of Montreal, Canada. B172 601.13 Determination of Pair-Wise Protein Interactions Between Spt7 and Drosophila melanogaster SAGA Subunits. E.E. Colon Acosta, V. Weake, R. Stegeman, A. Harris. University of Puerto Rico, Arecibo Campus, Puerto Rico and Purdue University. B173 601.14 The Impact of T Cell Receptor Docking Geometry on T Cell Signaling. J. Devlin, D. Harris, N. Singh, S. Smith, D. Kranz, B. Baker. University of Notre Dame and University of Illinois.
602. PROTEIN MODIFICATIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F
B175 602.2 Probing the Chromophore of the Green Fluorescent Protein with 4-Cyano-L-Phenylalanine. J. Piacentini, G.M. Olenginski, S.H. Brewer, C.M. Phillips-Piro. B176 602.3 Phosphorylation Regulates Apoptotic Caspase Function Through Diverse Molecular Mechanisms. J.A. Hardy, B.P. Serrano, S.J. Eron. University of Massachusetts. B177 602.4 Protein Succination: A Biomarker of Mitochondrial Stress in Adipose Tissue Inhibits Protein Function and Is Regulated by Nutrient Balance. A.M. Manuel, M. Walla, G. Piroli, N. Frizzell. University of South Carolina School of Medicine and University of South Carolina. B178 602.5 Phosphorylation of a Master Transcription Factor in Human Organogenesis Regulates Developmental Fate. Y. Chen, N.B. Phillips, M.A. Weiss. Case Western Reserve University. B179 602.6 Creating Peptide Hydrazides via Intein Splicing for Native Chemical Ligation and Protein Labeling. D.A. Santoleri, J. Liu, O. Ekanayake, S. Rozovsky. University of Delaware. B180 602.7 Role of SUMOylation in Alcohol-Induced Liver Fibrosis. M. Tomasi, C. Cossu, K. Ramani. Cedars-Sinai Medical Center. B181 602.8 Novel Physiological Targets of FicMediated Adenylylation/AMPylation. S. Mattoo, A. Sanyal. Purdue University. B182 602.9 Role of Sumoylation in Alcohol Dehydrogenase 1 (ADH1) Stability and Activity in Alcoholic Liver Disease. C. Cossu, Y. Spissu, A. Floris, M. Tomasi. Cedars-Sinai Medical Center. B183 602.10 Role of Sumoylated SOD2 in Alcoholic Liver Disease and Liver Cancer. Y. Spissu, C. Cossu, A. Floris, M. Tomasi. Cedars-Sinai Medical Center. B184 602.11 A High-Throughput Approach to Annotate the Lysine Methylome. E.M. Cornett, B.M. Dickson, K. Krajewski, M.W. Cowles, Z. Sun, S.B. Rothbart. Van Andel Research Institute, University of North Carolina and EpiCypher. B185 602.12 Posttranslational Arginylation Enzyme Ate1 Affects DNA Mutagenesis by Regulating Stress Response. A. Kumar, M.D. Birnbaum, D. Patel, W.M. Morgan, J. Singh, A. Barrientos, F. Zhang. University of Miami. B186 602.13 Inhibition of Sodium Hydrogen Exchanger 1 Palmitoylation Is Associated with Suppression of Cell Migration. M.J. Hovde, A.J. Kooiker, D.E. Rastedt, J.J. Provost, R.A. Vaughan, M.A. Wallert, J.D. Foster. University of North Dakota School of Medicine & Health Sciences, Bemidji State University and University of San Diego. B187 602.14 Obesity-Mediated Regulation of the Cardiac Acetylome. S.S. Romanick, A. Hostler, K. Schlauch, D. Quilici, Y. Feng, B. Ferguson. University of Nevada Reno. B188 602.15 NAD+ replacement Therapy with Nicotinamide Riboside Does Not Improve Cardiac Function in a Model of Mitochondrial Heart Disease. A.R. Stram, P.M. Pride, R.M. Payne. Indiana University School of Medicine.
Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B174 602.1 The Localization to PML Nuclear Bodies and Stability of TRAIP/RNF206 Are Controlled by Sumoylation. Y. Han, I. Park, H. Kim. Sungkyunkwan University, Korea, Republic of, Pasteur Korea, and Republic of Korea.
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603. PROTEIN STRUCTURE AND BIOPHYSICS (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Structure and Biophysics (II), Monday, Protein Structure and Biophysics (III), Tuesday B189 603.1 Influenza Hemagglutinin Fusion Domain by Advanced NMR Using Novel Orthagonal Refinement, BICS Curvature Measurements and Native Lipid Environments. S.T. Smrt, B. Mendis. University of Illinois at Chicago. B190 603.2 Structural Differences Associated With DNA Binding of p53 Family Member Proteins. G.R. Mavodza, Y. Fang, Z. Sherif. Howard University. B191 603.3 Ligand Induced Shift in FRET Spectrum of MDA5/LGP2 Signaling Complex. J. Corby, M. Stoneman, G. Biener, V. Raicu, D. Frick. UW Milwaukee. B192 603.4 Insights Into the Mechanism of Protein Functional Loss Upon Covalent Modification by Homocysteine Thiolactone. G.S. Sharma, L.R. Singh. Dr. B. R. Ambedkar Centre for Biomedical Research and University of Delhi, India. B193 603.5 Structure of hRpn13 at the Proteasome. X. Lu, F. Liu, U. Nowicka, V. Sridharan, M. Dyba, S.G. Tarasov, K.J. Walters. Center for Cancer Research, National Cancer Institute. B194 603.6 A Conformationally Gated Model for Serotonin 5-HT1B/1D Receptor Agonist Transport by P-Glycoprotein. L.A. Wilt, K.P. Sigdel, D. Nguyen, G.M. King, A.G. Roberts. University of Georgia and University of Missouri. B195 603.7 Significance of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase. Z. Ahmad. A.T. Still University. B196 603.8 Structural Insights Into Oxalate Biosynthetic Component. S. Rhee, J. Oh, S. Kim. Seoul Nat’l University, Republic of Korea. B197 603.9 Solution Structure of the Transmembrane Nogo-B Receptor and Insight Into Its Topological Orientation by Small Angle X-Ray Scattering Analysis. J. Holcomb, N. Spellmon, W. Shang, Q. Miao, Z. Yang. Wayne State University School of Medicine, BioCAT, Argonne National Laboratory and Medical College of Wisconsin. B198 603.10 The Importance of a Salt Bridge in FNR Transcription Factor Activity. S.G. Kazmouz, L.J. Badang, L.J. Moore. Monmouth College. B199 603.11 Thermodynamics of the Gamma B Crystallin Protein Demonstrated by T1/T2 NMR Experiments. K. Umphred-Wilson, A. Fadden, J. Zanet, K. Mathews, G. Thurston, J. Mills, L.V. Michel. Rochester Institute of Technology. B200 603.12 Structural and Functional Basis of GusRMediated Regulation of β-Glucuronidase Expression in Enterobacteriaceae Gastrointestinal Pathobionts. M.S. Little, S.J. Pellock, W.W. Walton, M.R. Redinbo. University of North Carolina at Chapel Hill. B201 603.13 Unique Solutions to a Common Problem: Understanding How I-CreI Homologs Recognize the Same DNA Target Sequence. C.R. Polkinghorn, B. Kaiser, N. Wylie, M. Tang, R. Ruff. Seattle University.
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B202 603.14 Polar Subdomain Alterations Lead to β-Helix Aggregation. D. Sweeting, D. Grilley, T. Weaver. University of Wisconsin La Crosse. B203 603.15 Probing Solvation Environments in Tt H-NOX by Site-Specific Incorporation of 4-Cyano-L-Phenylalanine. C. Kearney, L.T. Olenginski, D. Tariq, T.D. Hirn, S.H. Brewer, C.M. Phillips-Piro. Franklin & Marshall College. B204 603.16 Labilization of the Cobalt-Carbon Bond in Vitamin B12 Bound to Adenosyltransferase. G.C. Campanello, U. Twahir, T. Brunold, K. Warncke, R. Banerjee. University of Michigan, Emory University and University of Wisconsin. B205 603.17 Structural Changes in the Nickel-Responsive Regulator NikR from Helicobacter pylori K.A. Baksh, J. Wong, T. Pham, D.B. Zamble. University of Toronto, Canada. B206 603.18 SAXS: A Versatile Tool to Study Biological Macromolecules in Solution. W. Ma, S. Chakravarthy, W. Shang, T. Irving. Illinois Institute of Technology. B207 603.19 Targeting the Hendra Virus Fusion Protein Transmembrane Domain to Inhibit Viral Fusion. C. Barrett, S. Webb, R. Dutch. University of Kentucky. B208 603.20 Exploring the Structural Impact of Unnatural Amino Acids on Protein Structure. N.S. Savidge, N. Maurici, S.H. Brewer, C.M. Phillips-Piro. Franklin and Marshall College. B209 603.21 Role of the Transmembrane Domain of Mucin 1 in Nuclear Localization. G.J. O’Connor, C. Freeman, E. Li. Saint Joseph’s University. B210 603.22 Biochemical and Biophysical Comparison of the Human and Drosophila melanogaster I Kappa B Kinase Protein Complexes Suggest Structural Conservation. W.E. Rogers, T. Huxford. San Diego State University and University of California—San Diego. B211 603.23 Prediction of the Entamoeba histolytica Alcohol Dehydrogenase 2 (EhADH2) Protein Structure Using Bioinformatics Tools. K. Lowerre, C. Hemme, A. Espinosa. Roger Williams University and University of Rhode Island. B212 603.24 New ABCG2 Homology Model Reveals Importance of C-Terminus in Protein Trafficking. J. Cui, H. Sayed, J. Huang, O.M. Woodward. Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, People’s Republic of China, and University of Maryland School of Medicine.
604. PROTEIN FOLDING AND CHAPERONES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B213 604.1 Heat Shock Protein 90 Is Critical for Plasmodium Parasite Liver Stage Development. A.I. Keim, D. Posfai, T.A. Haystead, E.R. Derbyshire. Duke University. B214 604.2 Understanding the Influence of TranslationElongation Kinetics on Protein Structure and Function. E.P. O’Brien. Penn State University. B215 604.3 The Structural Basis for Polypeptide Translocation by the HSP104 Disaggregase. D.R. Southworth, A. Yokom, S. Gates, M. Jackerel, J. Shorter. University of Michigan and University of Pennsylvania.
SUNDAY BIOCHEMISTRY B216 604.4 Engineering Potentiated Hsp104 Variants with Enhanced Substrate-Specificity to Counter Neurodegeneration. K.L. Mack, J. Shorter. Perelman School of Medicine at the University of Pennsylvania. B217 604.5 Inorganic Polyphosphate: A Mediator of Protein Folding in Osteoblasts via Interaction with Cyclophilin B. M. Khong, L. Li, C.Y. Lang, J.A. Tanner. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Neuroscience Research Institute, Peking University, People’s Republic of China. B218 604.6 Chaperoning the Proteome. W.A. Houry. University of Toronto, Canada. B219 604.7 Redox Modification of Fes1 and Its Role in Cellular Oxidative Stress Response. E. Nicklow, C. Sevier. Cornell University. B220 604.8 Periplasmic Chaperones Play Hot Potato with Unfolded Outer Membrane Proteins. K.G. Fleming, S.M. Costello, A.M. Plummer, P.J. Fleming. Johns Hopkins University. B221 604.9 Characterization of Sup35, Rnq1, and Ure2 Cotranslational Prion Aggregation in Saccharomyces cerevisiae. B.T. Allwein. Ursinus College. B222 604.10 Inter-Domain Interactions in Nascent Polypeptides Interfere with Productive Protein Folding. K. Liu, K. Maciuba, C. Kaiser. Johns Hopkins University. B223 604.11 Defining Functional Variation of Diverse Hsp104 Homologues. Z. March, J. Shorter. Perelman School of Medicine at the University of Pennsylvania. B224 604.12 The Ribosome-Associated Complex Suppresses [PSI+] Prion Formation in Yeast. C. Kelly, T. Tessitore, J. Taddeo, D.M. Cameron. Ursinus College. B225 604.13 The Role of Rr-Resident Lectin Chaperone UGT1 in MHC Class I Peptide Loading. N. Arshad, P. Cresswell. Yale University School of Medicine. B226 604.14 Allosteric Landscape of a Stress-Inducible Human Hsp70 Molecular Chaperone. W. Meng, E.M. Clerico, N. McArthur, L.M. Gierasch. University of Massachusetts and Amherst. B227 604.15 Functional Characterization of Natural Single Nucleotide Polymorphisms Found on HSPA1A, the Major Stress Inducible 70 kDa Heat Shock Gene in Humans. R. Oliverio, N. Nikolaidis. California State University at Fullerton. B228 604.16 Dual Function of the Trigger Factor Chaperone in Nascent Protein Folding. C. Kaiser, K. Maciuba, K. Liu. Johns Hopkins University. B229 604.17 Defining Interactomes of Wild-Type Versus Misfolding Type I Collagen Variants in Osteogenesis Imperfecta. D.N. Doan, A.S. DiChiara, A. Del Rosario, M.D. Shoulders. MIT. B230 604.18 Evolution and Natural Variation of HSPA1A, the Major Stress Inducible Gene, in Humans. P. Nguyen, B. Kdeiss, S. Ord, K. Hess, R. Oliverio, N. Nikolaidis. California State University at Fullerton. B231 604.19 Identification of a Pharmaceutical Therapeutic for Nod2, a Protein Mutated in Crohn’s Disease, Through Development of a Screen Using Split GFP Complementation. H.C. Wastyk, C. Hou, C. Grimes. University of Delaware. B232 604.20 Loss of Sil1, an ER Co-Chaperone, Causes an Age-Dependent Collapse of Skeletal Muscle Proteostasis, Affecting Pathways Critical for Muscle Physiology. V.P. Ichhaporia, P. Vogel, S. Frase, L. Horner, L.M. Hendershot. St. Jude Children’s Research Hospital and The University of Tennessee Health Science Center.
B233 604.21 New Insights from High-Throughput Biophysical Screening of Protein-Sequence and CodingSequence Libraries. B. Allen. Penn State University.
605. BIOMOLECULAR CATALYSIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B234 605.1 Thiol Addition to Conjugated Nitrolinoleic Acid. B. Alvarez, L. Turell, D.A. Vitturi, E.L. Coitiño, L. Lebrato, M.N. Moller, C. Sagasti, S.R. Salvatore, S.R. Woodcock, F.J. Schopfer. Universidad de la Republica, Uruguay, Uruguay and University of Pittsburgh. B235 605.2 Characterization of Recombinant Fructose1,6-Bisphosphatase (FBPase) Gene Mutations: Insights Into Modulation of FBPase Activity Through Gene Mutation. G. Topaz, V. Epiter-Smith, M. Emad, V. Ford, J. Daley, C. Silva, M. Subramanian, H. Sosa, K. Stieglitz. Roxbury Community College. B236 605.3 α-Effect Furnishes a Mechanistic Bypass for General Base Catalysis in Hedgehog Protein Autoprocessing. B. Callahan, J.L. Giner, D. Ciulla, M. Jorgenson. Binghamton University and SUNY Environmental Science and Forestry. B237 605.4 Protein-Based Models of Nickel Metalloenzymes. H.S. Shafaat, A.C. Manesis, C.R. Schneider, M.C. O’Connor. The Ohio State University.
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606. ENZYME MECHANISMS, KINETICS AND ENERGETICS (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Enzyme Mechanisms, Kinetics and Energetics (II), Monday B238 606.1 Evolutionary Insights Into Oxygen Sensing. T. Liu. University of Oxford, United Kingdom. B239 606.2 Metal Drives Chemistry: Dual-Function of Acireductone Dioxygenase Enzymes. A.R. Deshpande, K. Wagenpfeil, T.C. Pochapsky, G. Petsko, D. Ringe. Brandeis University, Allena Pharmaceuticals and Weil Cornell Medical School. B240 606.3 Inhibition of Acetyl Cholinesterase Extracted from Five Parts of the Brain by 5,6 Dihydroxytryptamine. M.H. Osman. Medical Research Institute, Egypt. B241 606.4 Defining Energetic Homeostasis in Toxoplasma gondii R.D. Murphy, A. Dhara, A.P. Sinai, M.S. Gentry. University of Kentucky. B242 606.5 Preliminary Characterization of Pyrimidine Biosynthesis Protein Aspartate Transcarbamoylase (ATC) in Pseudomonas aeruginosa C. Patel, F.A. Hachem, A. Vaishnav, B.F. Edwards, H.G. Evans, D.R. Evans. Wayne State University School of Medicine and Eastern Michigan University.
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BIOCHEMISTRY SUNDAY B243 606.6 Novel Thymidine Hypermodifications in Viruses Encoding a 5-Hydroxymethyl-5′-Deoxyuridine DNA Kinase. P.R. Weigele, S. Müller, Y. Lee, S. Walsh, C. Guan, N. Dai, I. Correa. New England Biolabs. B244 606.7 HLA–DM Senses Peptide-MHC Class II Interactions Throughout the Peptide Binding Groove. E. ReyesVargas, A.P. Barker, Z. Zhou, X. He, P.E. Jensen. University of Utah and ARUP Laboratories. B245 606.8 Examining the Mechanism of Egt2 in Ergothioneine Biosynthesis. K.R. Kathuria, S. Irani, P. Liu, Y. Zhang. The University of Texas at Austin and Boston University. B246 606.9 Aspartate Cyclization: The “Aspartic Acid Effect” in Pyrococcus abyssi and Deep-Sea Enzyme Pressure Studies. C.J. Minteer, K.M. Colelli, J.N. Reitter, K.V. Mills. College of the Holy Cross. B247 606.10 Investigating the Catalytic Cycle and Active Site Residues of the Biodesulfurizing Enzyme, Dibenzothiophene Monooxygenase, DszC. S.A. Jirde, L. Gonzalez-Osorio, K. Eberle, J. Vey. California State University at Northridge. B248 606.11 The E. coli and Human Nudix Hydrolases NudC and NUDT12 Cleave Damaged NADH. A. Ray, B.A. Beaupre, G.R. Moran, D.N. Frick. University of Wisconsin—Milwaukee. B249 606.12 Salt-Dependent Protein Splicing of the Intein in the Haloquadratum walsbyi DNA Polymerase. D.A. Reidy. College of the Holy Cross. B250 606.13 Differential Protein Splicing of Salt Dependent Inteins from Haloquadratum walsybi A.K. Lynch, S. Amunya, J. Reitter, K. Mills. College of the Holy Cross. B251 606.14 Investigation of the Third Step of Protein Splicing in Two Similar Cyanobacterial Inteins. C.K. Ramsoomair, A.E. Yakely, J. Reitter, K. Mills. College of the Holy Cross. B252 606.15 A Structural Investigation and Splicing Study of Inteins from Halobacteria. W. Zhang, A.K. Lynch, A.O. Gomez, J.N. Reitter, K.V. Mills. College of the Holy Cross. B253 606.16 Structural and Biochemical Analyses of Alcohol Dehydrogenase E Enzymes from Entamoeba invadens IP-1, E. invadens VK-1:NS and E. dispar M. Gabrielle, J. Leito, A. Espinosa. Roger Williams University. B254 606.17 Role of Cys292 in Coupling ATP Hydrolysis to RNA Unwinding Catalyzed by the Hepatitis C Virus Helicase. M.M. Yerukhimovich, D. Frick, C. Marohnic. University of Wisconsin Milwaukee and Abbott Laboratories. B255 606.18 Purification and Characterization of Flavin Reductase, DszD, from Rhodococcus erythropolis G. Mendez. California State University at Northridge. B256 606.19 Conditional Protein Splicing of Inteins from Extremophiles. A. Gomez, K.V. Mills. College of the Holy Cross. B257 606.20 Investigating Metallocofactor Assembly and Enzymatic Capability In the Novel Mn/Fe Lipid-Binding Oxidases. E.K. Miller, N.E. Trivelas, P.T. Maugeri, H.S. Shafaat. The Ohio State University.
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607. STRUCTURAL DYNAMICS OF ENZYMES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B258 607.1 Functional Characterization of Three GH10 Xylanases. J. Park, E. Glasgow, B.G. Fox. Winthrop University and University of Wisconsin—Madison. B259 607.2 Using Dynamics and Structure to Understand Allostery in Signaling Enzymes. W. Peti. University of Arizona. B260 607.3 Understanding the Allosteric Control of Kinase Activation by Phosphorylation-Regulated Protein Dynamics. D.B. Iverson, N. Ahn. University of Colorado and Boulder. B261 607.4 Probing Carrier Domain Movement and Location During Catalytic Turnover by Pyruvate Carboxylase. M. St Maurice, Y. Liu, J.H. Hakala. Marquette University. B262 607.5 Measuring the Positioning and Translocation of the Swinging-Arm Domain of Pyruvate Carboxylase. J.H. Hakala, M. St. Maurice. Marquette University. B263 607.6 Unmixing Enzyme Allostery. S. Meisburger, N. Ando, A.B. Taylor, C.A. Kahn, S. Zhang, P.F. Fitzpatrick. Princeton University and University of Texas Health Science Center. B264 607.7 A Novel, Green Synthesis of Deuterium Labeled Compounds. D. Kadish, A. Kokel, M. Torok, B. Torok. University of Massachusetts and Boston. B265 607.8 A Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates. A.I. Celis. Montana State University. B266 607.9 Deciphering the Logic of Natural Product Biosynthesis. B. Li. University of North Carolina at Chapel Hill.
608. CHEMICAL BIOLOGY, DRUG DISCOVERY AND BIOANALYTICAL METHODS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B267 608.1 An Essential Oil Blend Specifically Enhances Immune Responses in Human Cancerous Co-Cultures. X. Han, T. Parker. doTERRA International. B268 608.2 Drugging the Undruggable Steroid Receptor Coactivators. J. Wang. Baylor College of Medicine. B269 608.3 Characterization of a Cardiac Drug-Inactivating Enzyme from the Prominent Human Gut Microbe, Eggerthella lenta. N. Koppel, J. Bisanz, P. Turnbaugh, E.P. Balskus. Harvard University and UCSF.
SUNDAY BIOCHEMISTRY B270 608.4 Synthesis, Antimicrobial Activity and Molecular Docking Studies of Novel Bioactive Fused Heterocyclic Systems. S. Govori Odai, A. Haziri, H. Ibrahimi, K. Ademi, N. Neziraj. University of Prishtina, Yugoslavia. B271 608.5 PTEN Regulation by WWP2. Z. Chen, D. Dempsey, W. Xu, X. Li, D. Dempsey, P. Devreotes, C. Wolberger, S. Gabelli, P. Cole. Johns Hopkins University. B272 608.6 Inorganic Arsenic Bioaccessibility/ Bioavailability from Cooked Rice Using in Vitro Digestion/ Caco-2 Cell Model. K. Lee, S. Lee. Korea University, Republic of Korea. B273 608.7 Total Synthesis, Antileishmanial and Anticancer Activity of the Acetylenic Fatty Acids 6-Hexadecynoic, 10-Phenyl-6-Decynoic, and 10-Cyclohexyl-6-Decynoic Acids. E. Álvarez, N. Carballeira, C. Morales, Y. Delgado, A. Tinoco, R. Reguera, R. Álvarez, R. Balaña. University of Puerto Rico, Rio Piedras Campus, Puerto Rico, University of Leon and Vegazana Campus, Spain. B274 608.8 Carbohydrate-Linked Cisplatin Analogue: Reactivity Studies with RNA and DNA. S.D. Thalalla Gamage, N. Muthunayake, A. Sonousi, D. Crich, C. Chow. Wayne State University. B275 608.9 Affinity Ligand for the Separation of Glycosylated Proteins from Non-Glycosylated Proteins. A. Gunter, C. Mammoser, S. Dhar, L. Rowe. Valparaiso University. B276 608.10 Development of a Microscopic Method for the Exposure of Hemoglobin C. K.L. Schmidt, T.R. Randolph. Saint Louis University. B277 608.11 Mechanistic Comparison of Structurally Divergent Transcriptional Coactivators Through Covalent Activator-Coactivator Complexes. A.R. Henderson, M. Beyersdorf, N. Foster, K. Sanford, M. Henley, A. Mapp. University of Michigan. B278 608.12 Development of Novel Small Molecule Antibiotics Against a Conserved RNA Element in Gram-Positive Bacteria. V.Y. Väre, K.M. Frohlich, G. Todd, J. Bell, P.F. Agris. SUNY at Albany and The RNA Institute. B279 608.13 Mechanism and in Vivo Activity of a Covalent Inhibitor of ERK Docking. K.N. Dalby, E.V. Anslyn, D. ZamoraOlivares, T. Kaoud. University of Texas at Austin. B280 608.14 Earmarking Target-Specific Redox Trajectories for Wound Healing in Zebrafish. Y. Aye. Cornell University and Weill Cornell Medical College.
609. DRUG SCREENING AND DEVELOPMENT Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B281 609.1 Simple Model for Screening Anti-Cell-Clumping Reagents: Acids. G. Zem, K. Pastrano, A. Strelnicova, M. Cabrera, J. Cuevas, L. Espinoza, C. Voskanian, R. Keshishian, S. Sorayazadeh, B. Alvarado, S. Pizana, A. Weisman-McCarley, K. DeGuzman, A. Pourkhayat, K. Ellikkal, A. Darmali, S. Oppenheimer. California State University at Northridge.
B282 609.2 Determining the LC50 of a Novel Metap Inhibitor in Lung Carcinoma Cells. A.P. Addison, N.F. Hayden, E. Perli, E. Erwin, G. Chow, L. Vu, S. Bhalla, N. Condic, O. Olaleye, R. Rosell. University of St. Thomas and Texas Southern University. B283 609.3 Optimization of a Medium-Throughput Cathepsin K Inhibition Assay for NAAA Inhibitors. E.R. Golden, C. Miyabe, J. Wood, M. Malamas, S. Alapafuja, A. Makriyannis. Northeastern University. B284 609.4 Assessing the Effects of ErbB2 Kinase Inhibition in Conjunction with Broad Spectrum Anti-Cancer Treatments. C. Tremper, A.R. Matha, C.E. Taylor. Mercyhurst University. B285 609.5 Identification of Yeast Deletions Strains That Alter the Efficacy of Antifungal Drugs. E. Bataba, N.D. Serratore, S.D. Briggs. Georgia State University and Purdue University. B286 609.6 The PepSAVI-MS Pipeline for Natural Product Bioactive Peptide Discovery. C.L. Kirkpatrick, D. Pritchard, N. Parsley, Y. Liu, D.W. Hoskin, L.N. Shaw, L.M. Hicks. University of North Carolina, Chapel Hill, Dalhousie University, Canada and University of South Florida. B287 609.7 A Cell-Based inhibitor Screening Platform for S-Adenosylmethionine Synthetase. G. Parungao, M. Dziobak, R. Blumenthal, R. Viola. The University of Toledo. B288 609.8 Viable Strategy for Inhibition of Death Receptor 5 Signaling by Disrupting Receptor-Receptor Interactions. N. Vunnam, C. Lo, B.D. Grant, D.D. Thomas, J.N. Sachs. University of Minnesota. B289 609.9 Improving the Sensitivity of P-Glycoprotein to Drug-Like Inhibitors in ATPase Assays and ESR Studies. G. Chen, J. Ballou-Crawford, J.G. Wise, P.D. Vogel. Dept. of Biological Sciences and the Center for Drug Discovery, Design and Delivery and Southern Methodist University. B290 609.10 New Strategies for the Expression of Human P-Glycoprotein (MDR1) in the Yeast Pichia pastoris. M.C. de Oliveira, C.A. Lavigne, H.A. Thornton, B.M. Tran, J.G. Wise, P.D. Vogel. Southern Methodist University. B291 609.11 Inhibition of Tumor Necrosis Factor Receptor 1 Signaling by Small Molecules. C. Lo, N. Vunnam, A. Lewis, T. Chiu, B. Brummel, T. Schaaf, B. Grant, P. Bawaskar, D. Thomas, J. Sachs. University of Minnesota, Fluorescence Innovations Inc and Photonic Pharma LLC. B292 609.12 Elucidation of the Cell Death Pathways Induced by Aqueous-Stable Titanium(IV) Compounds as Potential Anticancer Agents. Y. Delgado, A. Vázquez, M. Kowaleff, M. Saxena, Z. Torres, A. Tinoco. University of Puerto Rico Rio Piedras Campus and City University of New York. B293 609.13 In Vivo Drug Discovery for Progressive Supranuclear Palsy Using a Novel Zebrafish Model. E.A. Burton, Q. Bai. University of Pittsburgh. B294 609.14 Acetaminophen Hepatotoxicity Testing Using 3D Rat Hepatocyte Cultures. V. Paliwal, M. Clapham. Milwaukee Sch. Engineering and Drake University. B295 609.15 The Antimicrobial Property of the Acetone Extract of Cola acuminate. B.J. Thomas, C.M. Telles. Southern University and A&M College. B296 609.16 Determining the Correlation Between Drosophila melanogaster Toluene Exposure and the Resulting Toxicity Effects on Fly Survival and Fecundity. V. Trivino, M. MacGregor, T. Nguyen, B. Nunez, Z. Lodhra, L. Castillo, B. Luu, R. Rosell, E. Ledesma. University of St Thomas.
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610. PROTEIN AND PEPTIDE CHEMISTRY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B297 610.1 Enzyme-Catalyzed Expressed Protein Ligation. S. Henager, N. Chu, Z. Chen, D. Bolduc, D. Dempsey, Y. Hwang, J. Wells, P. Cole. Johns Hopkins University and University of California at San Francisco. B298 610.2 Effect of Bleaching Products on Proteins of Teeth. R. Frazier, A. Panah, K. Keenan. Stockton University. B299 610.3 Effect of Bleaching Products on the Collagen of Teeth. C. Cavallaro, C. Schiliro, K. Keenan. Stockton University. B300 610.4 Anti-Cancer Properties of the Antimicrobial Peptide CDT on A549 Lung Cancer Cells. N. Hendrickson, A. Eitel, M. Jujjavarapu, J. Guthrie, H. Evans, D. Heyl-Clegg. Eastern Michigan University. B301 610.5 Disruption of the Dopamine D1/D2 Heteromer Using Synthetic Peptides. M. Champion, A. Baraka, H. Evans, D. Heyl-Clegg. Eastern Michigan University. B302 610.6 Analysis of the Stability of Natural and Unnatural Amino Acids in Extraterrestrial Conditions. C. Mammoser, B. Brown, S. Dhar, L. Rowe. Valparaiso University and Ivy Tech Community College. B303 610.7 Characterizing the Impact of the Highly Endosmolytic Cell-Penetrating Peptide, dfTAT, on Human Cells. H. Kondow. Texas A&M University. B304 610.8 Peptide Facilitated Intracellular Delivery of Quantum Dots for Live-Cell Imaging. C.I. Rivera Vera. University of Illinois at Chicago. B305 610.9 An Interdisciplinary Investigation of Antimicrobial Peptides. R.R. Wadhwa, R. Stevens-Truss. Kalamazoo College. B306 610.10 Targeting mER and GLP1R for the Treatment of Atherosclerosis and Type II Diabetes. J. Du, J.P. Issa, K. Kumar. Tufts University.
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611. SYSTEMS BIOLOGY TECHNOLOGIES AND APPLICATIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B307 611.1 Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. K. Liang, A.G. Volk, J.S. Haug, S.A. Marshall, A.R. Woodfin, E.T. Bartom, J.M. Gilmore, L. Florens, M.P. Washburn, K.D. Sullivan, J.M. Espinosa, J. Cannova, J. Zhang, E.R. Smith, J.D. Crispino, A. Shilatifard. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Stowers Institute for Medical Research, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Oncology Institute, Loyola University Chicago, Department of Pathology, Loyola University Chicago, Robert H. Lurie Comprehensive Cancer Center and Northwestern University Feinberg School of Medicine. B308 611.2 A Biosensing Soft Robot: Integrating Chemical and Optical Responsive Synthetic Cells with Soft Robotics. K. Justus, D. Lewis, C. Majidi, P. LeDuc, C. Tan. Carnegie Mellon University, University of California at Davis. B309 611.3 Lasertherapy After Induction of Myocardial Infarction by Coronary Artery Occlusion in Rats: A Genetic Signature. R.S. Feliciano, M.T. Manchini, E.T. Santana, J.V. Maretti, L.I. Caproni, E. Antonio, A.J. Serra, P.J. Tucci, J.A. Silva Jr. UNINOVE, Brazil, Universidade Nove de Julho, Brazil and UNIFESP, Brazil. B310 611.4 Optimization of Reconstituted High Density Lipoprotein (rHDL) Nanoparticles (NPs) for Short-Interfering RNA (siRNA) Delivery. L. Mooberry, N. Sabnis, A. Lacko. University of North Texas Health Science Center. B311 611.5 Delivery of siRNA Using Cationic Polymeric Nanoparticles to Understand the Localization and Function of GABAergic Neurotransmission in Planaria. K. Klasen, H. Ginter, S. Shankar, L. Ramakrishnan. St. Cloud State University. B312 611.6 Using CRISPR Technology to Edit the F508 Deletion of the Cystic Fibrosis Transmembrane Regulator Gene. K. Heavenor, J. Roecklein-Canfield. Simmons College.
SUNDAY BIOCHEMISTRY
612. GENOMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B313 612.1 HLA-DQ1 Alpha and Beta Genotypes Associated with Non-Celiac Gluten Sensitivity. M. Maki, D. Caporale. University of Wisconsin-Stevens Point. B314 612.2 Molecular Genotyping of Transposable Element Insertions in a Population of Uniform Mu Events. G.A. Arroyo Martinez, N. Springer. University of Puerto Rico at Ponce and University of Minnesota. B315 612.3 DC STAMP Domain: Intercompatibility Between SPE-42 and Other Proteins. I.S. Okeke. University of Alabama at Birmingham. B316 612.4 Factors That Differentiate Traumatic Brain Injury (TBI) Patients from Post-Traumatic Stress Disorder (PTSD) Patients Among Operation Enduring Freedom/ Operation Iraqi Freedom (OEF/OIF) Veterans. S. Miller, A. Gautam, N. Chakraborty, B. Sowe, A. Hoke, R. Yang, R. Hammamieh, M. Jett. The Geneva Foundation, USACEHR and Frederick National Laboratory for Cancer Research. B317 612.5 Characterization of a Plasmid Isolated from Enterococcus faecalis Found in the Fecal Material of a Blue Whale. R. McLaughlin, R. Kopanic. Gateway Technical College. B318 612.6 Validation of Single Nucleotide Polymorphisms in Physcomitrella patens. K. Adler, K.A. Hicks. Kenyon College. B319 612.7 Analysis of the Rates of Transcriptional Coupling and Translational Fusion Between Hydroxylase and Rubredoxin Subunits of Alkane Monooxygenase in Bacterial Genomes. H. Masuda, M. Rikard, P.R. Tupa. Indiana University Kokomo. B320 612.8 Unique Transposon Genome Rearrangements Identified in Elizabethkingia anophelis Outbreak Strains in the Midwest US. R. Flores, N. Torres, J. Matts, J. Gustafson, P. Canaan, P. Hoyt. Oklahoma State University. B321 612.9 Deciphering the Gene Expression Pattern from Human Blood Samples Collected in Multiple Collection Tubes. A. Hoke, A. Gautam, D. Donahue, S. Miller, S. Srinivasan, L. Detwiler, J. Lynch, M. Levangie, B. Sowe, R. Hammamieh, M. Jett. The Geneva Foundation, USACEHR and US Army Center for Environmental Health Research. B322 612.10 Using Transcriptomics for Biomarker Discovery Enabling High-Throughput Drug Screening of iPSCCardiomyocytes Modeling a Cardiomyopathy. T.J. Rowland, S.I. Hashem, K. Jones, A.J. Bonham, S. Jett, E. Adler, D. LaBarbera, L. Mestroni, M. Taylor. University of Colorado Denver Anschutz Medical Campus, University of California San Diego and Metropolitan State University of Denver. B323 612.11 An Investigation of the Oxidatively Damaged Transcriptome in the Human Neuronal Cells. P. Kharel, V. Gadepalli, A. Chattopadhyay, J. McDonough, S. Basu. Kent State University, Virginia Commonwealth University and University of Pittsburgh.
613. PHARMACOGENOMICS AND TOXICOGENOMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B324 613.1 Tox21 Enricher: Web-Based Chemical and Functional Enrichment Analysis Tool for Tox21 Toxicity Screening Platform. J. Hur, L. Danes, D. Krout, J. Hsieh, S. Auerbach. University of North Dakota and National Institute of Environmental Health Sciences. B325 613.2 Transcriptional and Translational Effects of Developmental Ethanol on Thyroid Function of Zebrafish. A.J. Holderman, R.C. Lawrence. Viterbo University. B326 613.3 Liver and Serum miRNAs in Toxic Liver Fibrosis. M.G. Permenter, D.L. Ippolito, V.A. Trabosh. Excet at US Army Center for Environmental Health Research and US Army Center for Environmental Health Research. B327 613.4 High Resolution Melting Analysis for the Study of Single Nucleotide Polymorphisms. G. Beuschel, C. Diez. Lawrence Technological University.
614. SIGNAL TRANSDUCTION AND CELLULAR REGULATION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F
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Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B328 614.1 Assessing Social Phenotypes of M. xanthus Following Homologous Recombination of Arg-Kinase Genes. M. Grady, D. Fraga, S. Kratt. College of Wooster. B329 614.2 CARMA2sh and Its Psoriasis-Linked Variants Regulate Inflammatory Pathways in Human Keratinocytes. I. Scudiero, P. Mazzone, G. Telesio, M. Pizzulo, P. Vito. Biogem S.c.a.r.l., Italy and Università degli Studi del Sannio, Italy. B330 614.3 Melatonin Modifies Peripheral Blood Cell Oscillators in Humans. E. Kostovski, E. Frigato, A. Dahm, G. Skretting, M. Mowinkel, P.M. Sandset, P.O. Iversen, C. Bertolucci. Clinical Medicine, University of Oslo, Norway, Sunnaas Rehabilitation Hospital, Norway, University of Ferrara, Italy, Oslo University Hospital, Norway, Akershus University Hospital, Norway and University of Oslo, Norway. B331 614.4 A Novel Role for Flotillin-1 in H-Ras-Regulated Breast Cancer Aggressiveness. A. Moon, M. Koh, H. Yong, E. Kim, H. Son, Y. Jeon, J. Hwang, M. Kim, Y. Cha, W. Choi, D. Noh, K. Lee, K. Kim, J. Lee, H. Kim, H. Kim, H. Kim, E. Kim, S. Park, H. Kim, W. Moon, H.C. Kim. Duksung Women’s University, Republic of Korea, Konkuk University, Republic of Korea, Seoul National University, Republic of Korea, Inha University, Republic of Korea, Seoul National University Bundang Hospital, Republic of Korea, and Wayne State University.
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BIOCHEMISTRY SUNDAY B332 614.5 Small Size of Membrane-Tethered Ligands Regulates Kinase-Phosphatase Segregation in Gamma/ Delta TCR Triggering. K. Choudhuri. University of Michigan Medical School. B333 614.6 Multi-Generational Silencing Dynamics Control Cell Aging. N. Hao, Y. Li, M. Jin, R. O’Laughlin, L. Tsimring, L. Pillus, J. Hasty. University of California San Diego. B334 614.7 TAK1/TRAF6 Signalling in Regulation of Skeletal Muscle Mass. A. Kumar, S.M. Hindi. University of Louisville School of Medicine. B335 614.8 General Amino Acid Control and 14-33 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Intracellular Gln3 and Gat1 Localization. T.G. Cooper, J.J. Tate, D. Buford, R. Rai. University of Tennessee Health Science Center. B336 614.9 Loss of MyoD Transdifferentiate Myoblasts Into Brown Adipocytes. C. Wang, W. Liu, Y. Nie, F. Yue, S. Kuang. Purdue University. B337 614.10 Novel Responsibilities for PKA Regulatory Subunits: Regulating Cell Migration Through the Assembly of a P-Rex1-Based Signaling Platform. S.R. Adame García, R.D. Cervantes-Villagrana, A. Castillo-Kauil, L. Chávez-Vargas, S.S. Taylor, G. Reyes-Cruz, J. Vázquez-Prado. CINVESTAV, Mexico and UCSD. B338 614.11 MiRNA-21 Mediates the Antiangiogenic Activity of Metformin Through Targeting PTEN and SMAD7 Expression and PI3K/AKT Pathway. M. Luo, X. Tan, Q. Wan, J. Wu. Drug Discovery Reseach Center, Southwest Medical University, People’s Republic of China, University of Missouri, Department of Endocrinology, The First Affiliated Hospital, Southwest Medical University, People’s Republic of China. B339 614.12 Elucidation of Molecular Signaling Battles Between the Eukaryotic Host and a Bacterial Pathogen. K. Orth, M. de Souza Santos, D. Salomon. HHMI, UT Southwestern Medical Center and UT Southwestern Medical Center. B340 614.13 Ras1 Phosphorylation and Its Role in Nutrient Signaling. S. Sethupathi, X. Jin, S. Starke, Y. Li, G. Kung, Y. Wang. Saint Louis University and St. Louis University. B341 614.14 Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells. F. Yue, P. Bi, C. Wang, J. Li, X. Liu, S. Kuang. Purdue University. B342 614.15 NOSTRIN Regulates Gene Signatures, Pleiotropic Functions and NFκB-TRAF6 Signaling Axis of Endothelial Cells: Implications in Intrauterine Growth Restriction. S. Chakraborty, R. Ain. CSIR-Indian Institute of Chemical Biology, India. B343 614.16 Dissecting JADE1 Pathway in the Regulation of Cytokinesis. M.V. Panchenko, B. Shao. Boston University School of Medicine. B344 614.17 Nanoparticles Mimic Exosomes and Attenuate Growth Factor-Induced Cell Migration in Melanoma Cells. B.P. Gallant, M. Clark, A. Madigan, Y. Wan, W. Zhang, H. Lu. Providence College, Guiyang Medical University, People’s Republic of China. B345 614.18 Modulation of MEK/ERK and mTOR Pathways by Na+-K+-ATPase and AMPK Inhibitors in Ovarian Cancer Cells. M.P. Clark, A. Madigan, B.P. Gallant, W. Zhang, H. Lu, Y. Wan. Providence College, Guiyang Medical University, People’s Republic of China.
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B346 614.19 Activation of the E3 Ligase Cbl by Neutrophil Cathepsin G Impairs CXC Chemokine Receptor 4 Signaling in Cardiomyocyte Degeneration. S. Shukla, K. Sikder, A. Sarkar, W. Liu, K. Rafiq. Thomas Jefferson Univerasity, Shanghai Tenth People’s Hospital, People’s Republic of China. B347 614.20 O-GlcNAc Regulates CD4+ T Cell Differentiation. M. Machacek, J. Li, T. Li, C. Slawson, P. Fields. University of Kansas Medical Center. B348 614.21 Disruption of the Cereblon Gene Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice. K. Lee, Y. Koo, C. Lee, C. Yoo. Seoul National University Hospital, Republic of Korea. B349 614.22 Determining the Link Between Mammalian p38 Stress Kinase Pathway and Peroxisomes. R. Singh, C. Chrestensen. Kennesaw State University. B350 614.23 Exosomes-Mediated mTOR Activation Is Involved in Ovarian Cancer Cell Aggression and Migration. A.P. Madigan, B. Gallant, M. Clark, Y. Wan, W. Zhang, H. Lu. Providence College, Guiyang Medical University, People’s Republic of China. B351 614.24 A Filamin Phosphorylation Gateway to GPCR Function. S. Ithychanda, K. Dou, S. Karnik, J. Qin. Cleveland Clinic. B352 614.25 Chronic Low-Grade Inflammation in Obesity and Diabetes Associated Colorectal Cancer Development. N. Kumar, J. Mishra, P. Kumar. Texas A&M University. B353 614.26 An Investigation of Sex Difference in Microglia Morphology and Function. J. Lawrence, A. Turano, J. Schwarz. University of Delaware. B354 614.27 The Yeast Claudin Dcv1 Is Essential for the Maintenance of Distinct Membrane Domains and Polarized Mating Functions. M.E. Sukumar, D.E. Stone. University of Illinois at Chicago. B355 614.28 PASsing on Signals: Activation of PAS Kinase by mTOR Orchestrates Epigenetic Processes of Stem Cell Differentiation. C.K. Kikani, X. Wu, J. Rutter. University of Utah School of Medicine. B356 614.29 The Effect of Proline Rich Tyrosine Kinase 2 Activity on the Na+-H+ Exchanger Isoform 1 Regulation of Cell Proliferation and Migration. K.P. Bagnell, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B357 614.30 The Phosphorylation of the Na+-H+ Exchanger Isoform I (NHE1) and Its Role in the Regulation of Cell Proliferation and Migration. T.M. Smith, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B358 614.31 Signaling and Secretion of Chemotactic Factors Regulated by Calcium-Sensing-Receptor Mutants Found in Breast Cancer Patients. L.B. Orduña, J.J. Hidalgo-Moyle, J. Vázquez-Prado, G. Reyes-Cruz. CINVESTAV, Mexico. B359 614.32 mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis Through PostTranscriptional Control of ATF4. C.C. Thoreen, Y. Park. Yale School of Medicine. B360 614.33 Encoding the Human Phosphoproteome in an Engineered Bacterial System. K. Barber, J. Rinehart. Yale University. B361 614.34 The Dynamics of an Infrared Light-Activated Adenylyl Cyclase During the Manipulation of Behavior in Caenhorabditis elegans. M. Szurgot, F.M. Janton, M. Nelson. Saint Joseph’s University.
SUNDAY BIOCHEMISTRY B362 614.35 Structure of the Two-Component Response Regulator RcsB-DNA Complex. E.V. Filippova, B. Zemaitaitis, A.J. Wolfe, W.F. Anderson. Northwestern University Feinberg School of Medicine and Loyola University Chicago Stritch School of Medicine. B363 614.36 G Protein-Coupled Estrogen Receptor (GPER)-Mediated Relaxation of Coronary Arteries Is Mitigated by Phosphorylation of ERK1/2 R.C. Harlow, X. Yu, B.P. Kotaki, J.N. Stallone, C.L. Heaps, G. Han. Texas A&M University and Michael E. DeBakey Institute. B364 614.37 Novel Genetic Variants in the Oxytocin Receptor Predict Oxytocin Non-Responsiveness in Pregnant Women. G.Y. Lee, N. Raghuraman, E.L. Reinl, S.K. England. Washington University in St. Louis and Washington University School of Medicine. B365 614.38 Wnt and Ca2+ Signalling Changes in LRRK2 Parkinson’s Disease Models. K. Harvey, A. Wetzel, M. Hughes, T. McKay, S. Waddington, A. Rahim. University College London, United Kingdom and Manchester Metropolitan University, United Kingdom.
615. GROWTH FACTOR AND CYTOKINE SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B366 615.1 Signaling Pathways Involved in TributyltinInduced Increases in Interleukin 6 Production by Lymphocytes. N. Hamza, S. Brown, M. Whalen. Tennessee State University. B367 615.2 Role of MAPKs and NFκB in TributyltinStimulated Interleukin 1 Beta Secretion and Production from Human Immune Cells. M. Boules, S. Brown, M. Whalen. Tennessee State University. B368 615.3 Involvement of MAPK Signaling Pathways in Tributyltin-Induced Increases of Interleukin 1 Beta and Interleukin 6 mRNA in Human Lymphocytes. S.D. Brown, M. Boules, N. Hamza, M. Whalen. Tennessee State University. B369 615.4 Methionine Sulfoximine Reduces Proinflammatory Cytokine Release by Murine Macrophages. T. Peters, A. Jambekar, W. Brusilow. Wayne State University. B370 615.5 A Single EGF Molecule Activates a Preformed EGFR Dimer: A Single-Molecule Multi-Color TIRF Microscopy Study. E. Saita, D. Mong, I.N. Maruyama. OIST, Japan. B371 615.6 Pentabromophenol, a Brominated Flame Retardant Derivate, Suppresses TGF-β Signaling by Sequester TGF-β Receptor from Cell Surface and Further Degradation Through a Caveolae-Mediated Endocytosis. P. Yang, C. Chen. National Sun Yat-sen University, Taiwan.
B372 615.7 Skeletal Muscle-Derived Cytokines Regulate Myogenesis by Modulating Cell Cycle Withdrawal. D. Kim, N. Singh, J. Chen. University of Illinois at Urbana Champaign. B373 615.8 Epidermal Growth Factor Receptor Family Signaling in the Regenerating Axolotl Lung. T.B. Jensen, P. Giunta, N.G. Schultz, H. Wong, J. Monaghan. Northeastern University. B374 615.9 Differential Activation of Class I Phosphoinositide 3-Kinase by Growth Factors. D. Ghosh, S.L. Liu, P. Cho. University of Illinois at Chicago.
616. HORMONE AND NUCLEAR HORMONE SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B375 616.1 A Novel Interaction Between β-Arrestins and Nuclear Steroid Receptors. M.G. Petrillo, J.A. Cidlowski. NIH/NIEHS. B376 616.2 Steroid Hormone Receptor Gene Expression as a Marker for Phenothiazine Induced Endocrine Disruption and Stress in Mummichog, Fundulus heteroclitus. J.M. Laperche, J.B. Chiari, R. Patel, C.L. McGinnis. Quinnipiac University. B377 616.3 Glucocorticoid-Driven Transcriptomes in Airway Epithelial Cell Models: Commonalities, Differences and Functional Insights. M.M. Mostafa, C.F. Rider, R. Newton. University of Calgary, Canada and University of British Columbia, Canada. B378 616.4 Bile Acid Binding Protein STARD5 Suppresses Doxorubicin-Mediated Apoptosis in H1792 Lung Adenocarcinoma Cells. B.J. Clark, S.M. Dougherty, B.G. Hill, C.M. Klinge. University of Louisville School of Medicine. B379 616.5 Endogenous Ligand for Orphan Nuclear Receptor NR2E3 Forms a Light-Sensitive Retinal Transcription System. B. Connor, Y. Lee. Johns Hopkins University. B380 616.6 Examining the Effects of Aldosterone on Putative Target Genes in Mouse Collecting Duct Cells. B. Nolan, K. Solocinski, M.L. Gumz, D. Zies. University of Mary Washington and University of Florida.
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617. PLANT HORMONES AND SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B381 617.1 Unraveling White Lupin’s Signal Transduction in Response to Phosphorus Deficiency Using iTRAQ Labeling, Phosphopeptide Enrichment, and Tandem Mass Spectrometry. M. Amadi, J. Cole, K. Li, R.J. Chalkley, A. Burlingame, C. Uhde-Stone. California State University East Bay, University of California at San Francisco. B382 617.2 Cracking the Interorganellar Communication Codes. A.J. de Souza, J. Svozil, J. Wang, H. Ke, Y. Xiao, W. Gruissem, K. Dehesh. UC Riverside, ETH Zurich, Switzerland and UC Davis. B383 617.3 Expression of E3-Ubiquitin Ligase Genes in P. patens During Sexual Reproduction. E.W. Abrash, K.A. Hicks. Kenyon College. B384 617.4 Identification of a Novel Gene in the Shade Avoidance Response in Plants. N. Wershoven, E. Giddings, A.E. Clark, C. Palmer. Castleton University. B385 617.5 Phosphatidic Acid-Protein Phosphatase 2A Interactions Regulate Haloptropic Bending in Rice. E. Han, D. Petrella, J. Lin, A. DeLong, J.J. Blakeslee. The Ohio State University and Brown University. B386 617.6 Characterizing of the Novel Gene At4g33666 in the Abiotic Stress Response in Arabidopsis. A.E. Miller Clark, N. Wershoven, C. Palmer. Castleton University.
618. EXTRACELLULAR MATRIX AND CELL SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B387 618.1 Thrombomodulin Promotes Cell Adhesion and Migration and Enhances Angiogenesis Through Interaction with Fibronectin. H. Wu, Y. Hsu, G. Shi. National Cheng Kung University, Taiwan. B388 618.2 Biliary Epithelial Cell and Macrophage CrossTalk Is Important to Cyst Progression. M.C. Munteanu, P. Sivasami, B. Ferencz, R.S. Mansat, N. Poudel, T. Watnick, F. Lupu, M. Hinsdale. Oklahoma State University, Oklahoma Medical Research Foundation and University of Maryland School of Medicine.
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B389 618.3 Structural and Functional Insights Into the Latrophilin3-FLRT3-UNC5D Complex That Mediates Glutamatergic Synapse Development. F. Ranaivoson, S. Ozgul, S. Kakehi, V. Jackson, F. Martini, F. Bergami, S. von Daake, E. Seiradake, D. Comoletti. CHINJ, RWJMS, Rutgers University and University of Oxford, United Kingdom. B390 618.4 Controlled BMP2 Release from Keratin-Based Hydrogels Modulates Osteoinduction. L.C. Olson, S.L. Hyzy, J.M. Saul, D.J. Cohen, I. Kajan, Z. Schwartz, B.D. Boyan. Virginia Commonwealth University, Miami University, University of Texas Health Science Center at San Antonio and Georgia Institute of Technology.
619. G PROTEINS AND SMALL GTPASES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B391 619.1 Bioluminescent Assay for GTPases Allows Measurement of GTPase, GAP, and GEF Activities. S. Mondal, K. Hsiao, S. Goueli. Promega Corporation. B392 619.2 Antidepressant Treatment Increases cAMP Signaling by Translocating Gas from Lipid Rafts and Increasing Association with Type 6 Adenylyl Cyclase (AC6) Independent of Action at Monoamine Transporters. J.M. Schappi, M. Rasenick. University of Illinois at Chicago. B393 619.3 DAPLE Links Heterotrimeric G Proteins to Wnt Signaling During Vertebrate Development. A. Marivin, V. DiGiacomo, A. Leyme, M. Garcia-Marcos. Boston University School of Medicine. B394 619.4 Translocation of the Non-Receptor Protein GIV/Girdin to the Plasma Membrane Activates Heterotrimeric G Proteins. A. Leyme, K. Parag-Sharma, V. DiGiacomo, A. Marivin, S. Broselid, M. Garcia-Marcos. Boston University. B395 619.5 Cloning of Novel Leukocytic X5 ARHGEF18 Proteoform for Functional Characterization. H.M. Schira, K.B. Turton, D.S. Annis, D.F. Mosher. Univeristy of Wisconsin-Madison. B396 619.6 Structural and Functional Studies of the Metastatic Factors P-Rex1 and P-Rex2: Toward Small Molecule Inhibitor Development. P. Sharma, E.M. Davis, J. Cash, J.J. Tesmer. University of Michigan. B397 619.7 Cardiovascular Development Defects Produced by Combined Loss of RGS6 and Oxidizable CaMKII Due to Defective Notch Signaling. B. Chakravarti, J. Yang, . Ahlers, Z. Luo, H.A. Flaherty, D. Meyerholz, M.E. Anderson, R.A. Fisher. University of Iowa, Iowa State University and Johns Hopkins University School of Medicine. B398 619.8 Structure of a GEM-Complexed Gai Protein Provides Novel Insights Into the Emerging Human GEMiome. I. Kufareva, N. Kalogriopoulos, S.D. Rees, N. Sun, N. Aznar, G. Chang, P. Ghosh. University of California at San Diego.
SUNDAY BIOCHEMISTRY B399 619.9 Dissecting the Roles of ARHGEFs in Eosinophil Polarization. F. Botros, K. Turton, D. Mosher. University of Wisconsin Madison. B400 619.10 Inhibition of Constitutively Active Gsα by Molecules Targeted at R231. M. Schumacher, J. Carroll, S.D. Anderson, P. Santos, Y. Thu, H. Nguyen, K. Bohlen, M. Poch, B.T. Andresen, R.P. Rylaarsdam. Benedictine University and Western University of Health Sciences. B401 619.11 Determinants in the C-Terminal Region of Gα12 and Gα13 Allow Distinct Mechanisms of Cell Growth Signaling. T.L. Fleming, T.E. Meigs. University of North Carolina Asheville. B402 619.12 ER/K Linked GPCR-G Protein Fusions Systematically Modulate Second Messenger Response in Cells. M. Dysthe, R.U. Malik, M. Ritt, R.K. Sunahara, S. Sivaramakrishnan. University of Minnesota, Twin Cities, University of Michigan, University of California at San Diego. B403 619.13 Identification of Endothelial Cell Specific RhoGAPs That Influence TCL Activation and Localization. R.R. Florke, M.J. Hamann. Bemidji State University. B404 619.14 Investigation of TCL/RhoJ Palmitoylation and Its Effects on Cellular Localization. A. Franzen, C. Dague, B. Tader, R.R. Florke, M.J. Hamann. Bemidji State University. B405 619.15 Kinetic Analyses on the Binding of the RhoGEF P-Rex1 by Gβγ and Potential Small Molecule Inhibitors. M. Shost, J. Cash, J. Tesmer. University of Michigan. B406 619.16 The Molecular Mechanisms of Prostaglandin E2 Receptor 3 and Its Associated G Protein, GZ, in the Pancreatic β-Cell. M.D. Schaid, J. Wisinski, E. Laudre, M. Kimple. University of Wisconsin—Madison and University of Wisconsin—Madison. B407 619.17 Finding the Differential Interactome of Active vs Inactive Small Molecular Weight GTPases. T. Peterson, R.C. Piper. University of Iowa. B408 619.18 Determining the Structure of Oncogenic NRas Mutants. M. Ojeda, D. Reid, C. Mattos. Agnes Scott College and Northeastern University. B409 619.19 The C-Terminal Tail of TCL Localizes the GTPase to the Plasma Membrane of HeLa Cells. B. Tader, R.R. Florke, M.J. Hamann. Bemidji State University. B410 619.20 Investigating the Influence of the Rho-Family GTPase TCL/RhoJ on Vesicular Trafficking. T. Olson, S. Taylor, M.J. Hamann. Bemidji State University. B411 619.21 GTP-Loading Activity of TC10/TCL Chimeras Underscores Important Allosteric Regulatory Regions of TCL. G. Young, R.R. Florke, M.J. Hamann. Bemidji State University. B412 619.22 Transition State Mimic of Intrinsic Hydrolysis in Ras GTPase. A.Y. Ortiz. Northeastern University. B413 619.23 The Golgi Arf-GEFs Gea1 and Gea2 Integrate Signals to Coordinate Vesicle Formation. M.A. Gustafson, J. Fromme. Cornell University.
620. MICROBIAL SYSTEMS AND PARASITOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B414 620.1 Variants in the Toll-Interacting Protein Gene (rs5743899) and Susceptibility to Plasmodium falciparum Malaria Infection in West Africa. I. Farid, R.I. Funwei, S. Agyingi, T. Snyder, C. Falade, O. Ojurongbe, B.N. Thomas. Rochester Institute of Technology and Ladoke Akintola University of Technology, Nigeria. B415 620.2 Functional Characterization of Apically Localized Calmodulins That Regulate Motility and Cell Invasion in Toxoplasma gondii. S. Long. Washington University in St Louis. B416 620.3 Development of an Improved in Vitro Culture System for Cryptosporidium parvum. G. Wilke, L. FunkhouserJones, S. Ravindran, M. Kuhlenschmidt, T. Stappenbeck, L.D. Sibley. Washington University in St. Louis and University of Illinois. B417 620.4 Characterization and Partial Purification of an Inhibitory Factor Secreted by Bacillus anthracis and Aeromonas jandaei. J. McCartney, J. Nesemeier, N. Peterson. North Central College.
621. BACTERIAL COMMUNICATION Poster
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Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B418 621.1 Recognition and Selectivity of Peptide Pheromones by ComR in the Regulation of Natural Competence Among Streptococcus Species. G. Prehna, E. Shanker, D.A. Morrison, A. Talagas, S. Nessler, M.J. Federle. University of Illinois at Chicago and University of Paris-Sud, France. B419 621.2 Construction of a System for the Study of Protein-Induced Membrane Tubules. A. González Rivera, K.T. Forest. University of Wisconsin-Madison. B420 621.3 δ-Lactone Derivatives Induce Quorum Sensing Activity in Agrobacterium tumefaciens D.A. Ewald, A.K. Champion, M.R. Fry. Bradley University.
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622. MICROBE-HOST INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B421 622.1 Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOI. L1 D.A. MacDuff, T.A. Reese, M.T. Baldridge, J.M. Kimmey, L.A. Weiss, C. Song, T.J. Nice, J. Carrero, M. Colonna, B.T. Edelson, D. Sibley, C.L. Stallings, J. Casanova, K. Iwai, S. Virgin. University of Illinois at Chicago, University of Texas—Southwestern, Washington University in St Louis, Oregon Health and Sciences University, The Rockefeller University and Kyoto University, Japan. B422 622.2 Investigation Into a Cell-Density Dependent Pathway in Aerococcus urinae. E.E. Hilt, T.M. Halverson, K.L. Visick, A.J. Wolfe. Loyola University Chicago. B423 622.3 Collagen Mimetic Peptides as Probes for Bacterial Infection. A. Ellison, F. Dempwolff, D. Kearns, R. Raines. University of Wisconsin-Madison and Indiana University. B424 622.4 Metabolic Stress Drives Keratinocyte Defenses Against Staphylococcus aureus Infection. M.A. Wickersham, S. Wachtel, T. Wong Fok Lung, R. Jacquet, G. Soong, A. Richardson, D. Parker, A. Prince. Columbia University and University of Pittsburgh. B425 622.5 RRSP Exhibits Novel Proteolytic Activity. M. Lam, M. Biancucci, K.J. Satchell. Northwestern University and Northwestern University Feinberg School of Medicine. B426 622.6 Probiotic Escherichia coli Nissle 1917 Uses Zinc Transporters and the Siderophore Yersiniabactin to Acquire Zinc in the Inflamed Gut and Outcompete Salmonella typhimurium. J. Behnsen, J. Liu, M. Valeri, E. Hoover, J. Tjokrosurjo, N.P. Montaldo, S. Treacy-Abarca, O. Garibay, B.A. Gilston, R.A. Edwards, W. Chazin, E.P. Skaar, M. Raffatellu. University of California, Irvine, University of Illinois at Chicago, College of Medicine and Vanderbilt University. B427 622.7 Yersiniabactin Is a Recyclable Copper Importer in Pathogenic E. coli. A.E. Robinson, E. Koh, N. Bandara, B.E. Rogers, J.P. Henderson. Washington University. B428 622.8 Investigation of Controlled Expression of MS2 Lysis Protein. K.A. Rasefske, A.J. Piefer. Hartwick College. B429 622.9 Metabolic Immunomodulation of Macrophage Polarization by Pseudomonas aeruginosa Biofilms. M.B. Ammons, A.L. Fuchs, B.P. Tripet, V. Copie. Montana State University. B430 622.10 Relationship of Vpx and APOBEC3A. J. Rachuy, R. Moen, A. Land. Minnesota State University at Mankato. B431 622.11 Effects of Curcumin on Vesicular Stomatitis Virus (VSV) Infection and Dicer-1 Expression. J. Ahmed, Y. Tan, S. Ambegaokar. Ohio Wesleyan University. B432 622.12 A New Link Between Stress and Infection. N. Sule, S. Pasupuleti, N. Kohli, R. Menon, L. Dangott, M. Manson, A. Jayaraman. Texas A&M University and Texas A&M Health Science Center.
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B433 622.13 Isolating and Characterizing Predatory Bacteria from the Built Environment. L.C. Zappia, L.E. Williams. Providence College. B434 622.14 Escherichia coli tRNA Induces Mammalian Cell Migration and Socialization. A.K. Buechler, H. Zhao, D.J. Lieu, S.R. Blanke, S.A. Martinis. University of Illinois at Urbana-Champaign. B435 622.15 Subversion of Host Vesicular Trafficking by Phosphoinositide-Binding Bacterial Proteins. C. Pike, S. Lein, R. Neunuebel. University of Delaware.
623. PLANT-MICROBE INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B436 623.1 Photosynthetic Apparatus and Biochemical Parameters in Tomato and Squash Crops Influenced by Cucumber Mosaic Virus (CMV) Infection. M.S. Montasser, N.Y. Nayef, M. Afzal. University of Kuwait, Kuwait. B437 623.2 Metagenomic Analysis of Bacterial Communities in the Rhizosphere of Leguminous Crops and Trees. C. Ahrenhoerster, G. Prasad, B. Martinez-Vaz. Hamline University and University of Wisconsin- Milwaukee. B438 623.3 Structural Basis for Regulation of Rhizobial Nodulation and Symbiosis Gene Expression by the Regulatory Protein NolR. S. Lee, J. Jez. Washington University in St. Louis. B439 623.4 Chemical and Genetic Analysis of Hopped Meads. J.R. Halmo, M.J. Wolyniak, P.H. Mueller. HampdenSydney College. B440 623.5 Analysis of Bacterial Micro-Biome on Potato Tubers Treated with Sprout Regulator 1,4-Dimethylnaphthalene. R.A. Diaz, R.N. Patel, M.A. Campbell. Penn State Behrend. B441 623.6 Characterization of a Double Deletion Mutant of Fusarium verticillioides Lacking Two Putative Trehalose-6Phosphate Phosphatase Genes. B. McFarlin, E.S. Roberts, E.E. Remsen, C.M. McGovern, D.W. Brown, K.L. McQuade. Bradley University and USDA-ARS-NCAUR. B442 623.7 Isolation of Bio Energy Crop Phyllosphere Bacteria from Switchgrass. M.A. Sleda, K. Grady, K. O’Brien, A. Bennett, A. Shade. Lawrence Technological University and Michigan State University. B443 623.8 Expression and Purification of a Novel Calcium Binding Protein Necessary for Phytopathogenesis in Xanthomonas Strain. K.M. Margin, J.C. Quay, G.V. Minsavage, J.B. Jones, J.C. Hurlbert. Winthrop University and University of Florida. B444 623.9 The Characterization of Septoria lycopersici Pathogenicity in Micro Tom Tomatoes. K.E. Allen, J. ZwieslerVollick. Lawrence Technological University.
SUNDAY BIOCHEMISTRY
624. METABOLISM AND BIOENERGETICS
625. METABOLIC NETWORKS AND REGULATION
Poster
Poster
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:00 pm–2:30 pm
Presentation time: 12:00 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
B445 624.1 Response of the Energetic Metabolism of Saccharomyces cerevisiae to Different Nutritional Conditions of Carbon and Nitrogen. I.K. Olivares-Marin, L.A. MadrigalPérez, M. Canizal-Garcia, J.C. González-Hernández, C. Regalado-González. Universidad Autónoma de Querétaro, Mexico, Instituto Tecnológico Superior de Ciudad Hidalgo, Mexico and Instituto Tecnológico de Morelia, Mexico. B446 624.2 Cardiac Myocyte KLF5 Regulates Adiposity via Alteration of Cardiac FGF21. C.J. Pol, N.M. Pollak, M.J. Jurczak, I. Karagiannides, P. Ntziachristos, D.A. Scerbo, I. Aifantis, G.I. Shulman, I.J. Goldberg, K. Drosatos. LKSM Temple University, University of Graz, Austria, Yale University School of Medicine, David Geffen School of Medicine at UCLA, NYU School of Medicine, Columbia University and NYULangone School of Medicine. B447 624.3 Decreased Insulin Signaling Causes Loss of PFK-2 and Impaired Glycolysis in the Heart. K. Humphries, L. Bockus, C. Eyster. Oklahoma Medical Research Foundation. B448 624.4 Protein Modifying Enzyme Ate1 Controls Cellular Warburg Effects. C. Jiang, M. Birnbaum, D. Patel, A. Kumar, W. Morgan, T. Lampidis, F. Fontanesi, A. Barrientos, F. Zhang. Miller School of Medicine and University of Miami. B449 624.5 UCP1 Is Essential for Mitochondrial Structural Integrity and Function in Brown Adipose Tissue. C.L. Riley, C. Bean, D. Boutz, S. Kohno, G. Tioli, M. Genova, L. Scorrano, E.L. Mills. University of Texas at Austin, University of Padova, Italy, University of Colorado Denver and University of Bologna, Italy. B450 624.6 Genetic and Functional Characterization of the Enzymes of Nicotinic Acid Degradation in Bacillus niacini. T. To, M.J. Snider. The College of Wooster. B451 624.7 Enhanced Spare Respiratory Capacity in Extremophile Fish Following Exposure to Hydrogen Sulfide. C.R. Henpita, M. Tobler, J.H. Shaw. Oklahoma State University and Kansas State University. B452 624.8 Knockout of p53 Decreases Cardiac Injury by Reducing Ros Generation During Ischemia-Reperfusion. E. Lesnefsky, J. Thompson, Y. Hu, Q. Chen. McGuire VAMC and Pauley Heart Center-VCU.
B453 625.1 Hepatic Fat Accumulation Regulates Carnitine Palmitoyltransferase 1 (Cpt1a) Expression Through Coordinated Epigenetic Mechanisms. L. Moody, P.M. Jung, A. Kriska, H. Chen, Y. Pan. University of Illinois Urbana Champaign. B454 625.2 Administration of Naoxintong to db/db Mice Inhibits the Development of Diabetic Nephropathy. S. Yang, M. Liu, P. Su, J. Han. Nankai University, People’s Republic of China. B455 625.3 The Chemical Biology of Cellular Iron Pools in Prokaryotes. F. Outten, N. Bolaji, J. Wofford, P. Lindahl. University of South Carolina and Texas A&M University. B456 625.4 Gene and Protein Profiling of Effects of Tart Cherry Anthocyanins in Preadipocytes. S.H. Jayarathne, S. Scoggin, K. Claycombe, R. Kottapalli, M. Zabet, R. Bhawal, N. Moustaid-Moussa. Texas Tech University and USDA ARS. B457 626.1 Identifying a Source of Beta-Alanine and Its Broader Implications in Arabidopsis thaliana by GC/MS. M. Perrett, M. Gothard, A. Ludwig, K.A. Rouhier. Kenyon College. B458 626.2 Glutaminase Acts in Osteoblasts to Regulate Bone Formation. C.M. Karner, Y. Yu, J. Tang. Duke University. B459 626.3 Comparison of the Influence of Pre-Exercise BCAA Supplementation on Serum HMB Level Between Endurance and Resistance Exercises. T. Miyazaki, S. Ra, K. Ishikura, H. Ohmori, T. Ikegami, Y. Matsuzaki, A. Honda. Tokyo Medical University Ibaraki Medical Center, Japan, Fukuoka University, Japan, Sojo University, Japan and University of Tsukuba, Japan. B460 626.4 Identification of NADPH-Dependent Glutamate Dehydrogenase in Yarrowia lipolytica. K. Nelson, K. Juco, L. Tamayo, J. Nicaud, P.J. Trotter. Augustana College, INRA and AgroParisTech, France. B461 626.5 Time-Resolved Analysis of Amino Acid Deprivation Responses Reveals Dynamic Relationship Between GCN2 and mTOR. C1. I.A. Nikonorova, M.P. Goudie, E.T. Mirek, Y. Wang, T.G. Anthony. Rutgers, The State University of New Jersey and Center for Health and Human Performance. B462 626.6 Hormonal Regulation of Glycine Metabolism and Its Potential Role in Diabetes Susceptibility. R. Jog, J. Wang, T. Leff. Wayne State University. Kinetic Characterization of B463 626.7 3-Hydroxyisobutyrate Dehydrogenase from Arabidopsis thaliana. C. Binkley, M. McCool, T. Maurer, K.A. Rouhier. Kenyon College. B464 626.8 Cloning and Characterization of Putative Histidinol-Phosphatase Not Called by Machine Annotation. S. Ellis. St. Cloud State University. B465 626.9 Subtle Defects of Four Homocystinuric Variants of Human Cystathionine β-Synthase. J.P. Hines, Y. Su, A.T. Smith, J.N. Burstyn. University of WisconsinMadison, University of Maryland and Baltimore County.
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627. NUCLEOTIDE METABOLISM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B466 627.1 Purine Salvage Drives the Efficacy of an Adenosine Analog Inhibitor of Leishmania RNA Virus 1 (LRV1). J.I. Robinson, F.M. Kuhlmann, S.M. Beverley. Washington University School of Medicine.
628. PLANT METABOLISM AND BIOSYNTHETIC PATHWAYS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B467 628.1 Linking the Cytosolic Phenylalanine Pathway and the Auxin Biosynthetic Pathway. A. Garcia, Y. Qian, J. Lynch, N. Dudareva. Tennessee State University and Purdue University. B468 628.2 Biosynthesis of Granatane Alkaloids in Punica granatum. B.G. Chavez, L. De-Vries, K. Galloway, J. D’Auria. Texas Tech University. B469 628.3 Engineering Biochemical Bypass to Photorespiration to Improve Photosynthesis and Crop Production. P. South, D.R. Ort. USDA-ARS/University of Illinois and USDA-ARS. B470 628.4 Molecular Basis of TyrA Substrate Specificity Underlying the Evolution of Alternative Tyrosine Biosynthetic Pathways. C. Schenck, C. Holland, M. Schneider, J. Jez, H. Maeda. University of Wisconsin-Madison and Washington University in St. Louis. B471 628.5 Does Sensitivity to FACs Result in Higher Resistance Against Herbivory? A. Conner, L. Grisset, J. Stratmann. University of South Carolina. B472 628.6 cDNA Cloning and Characterization of UDPGlucosyltransferase from Indigofera tinctoria. S. Inoue, R. Morita, S.T. Thul, B.K. Sarangi, Y. Minami. Okayama University of Science, Japan and CSIR-NEERI, India. B473 628.7 Tyrosine Biosynthesis Revisited: Characterization of Novel Arogenate Dehydrogenases from Legumes. M.R. Schneider, C.A. Schenck, C.K. Holland, J.M. Jez, H.A. Maeda. University of Wisconsin-Madison and Washington University in St. Louis. B474 628.8 A Study of the Exchangeable Protons in the QA Site of Photosystem II. A. Garmany, Z.D. Runyon, D.S. Kinzer, S. Dikanov, D.R. Kolling. Marshall University and University of Illinois at Urbana—Champaign. B475 628.9 Characterization of Mutant Sunflower Acetoacetyl CoA Thiolase. J. Dyer. Montclair State University.
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B476 628.10 Identifying the Metal That Activates the Prenyltransferase That Catalyzes Formation of Geranyl Diphosphate in the Diatom Pseudo-nitzschia multiseries. H. Tran, T. Savage. California State University Sacramento. B477 628.11 Understanding Plant Energy Sensing and Homeostasis. S. Williams, J. Yen, G. Gillaspy. Virginia Tech. B478 628.12 Inositol Phosphates and Energy Signaling in Plants. O.A. Adepoju, S.P. Williams, G. Gillaspy. Virginia Polytechnic Institute and State University.
629. LIPIDS AND MEMBRANES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B479 629.1 Independent Measurements of Lipids in Mixed Cell Populations. A. Stoeckman, K. Estrada, N. Wolins. Bethel University and Washington University. B480 629.2 Structure of Human Niemann-Pick C1 (NPC1) Protein and NPC1-NPC2 Complex. X. Li. Rockefeller Univeristy. B481 629.3 Monitoring Live Cell Membrane Lipid Encounter Dynamics with DNA Probe. M. You. UMass Amherst. B482 629.4 OlyA—A Tool to Study SphingomyelinCholesterol Interactions in Plasma Membranes. S. Endapally, A. Radhakrishnan. UT Southwestern Medical Center. B483 629.5 Role of Na-H Exchanger-2 in Experimental Colitis: Mechanism of Regulation of Expression. I. Khan, A.A. Soleiman, F. Thameem. Kuwait University, Kuwait, Kuwait and Kuwait University, Kuwait. B484 629.6 Repurposing P-Glycoprotein Inhibitors as Modifiers of Sphingolipid Metabolism—Therapeutic Implications in Cancer. M.C. Cabot. East Carolina University and Brody School of Medicine. B485 629.7 A Common Tale of Substrate Recognition: From Antibiotic Resistance to Neurotransmitter Transport. D. Yaffe, A. Vergara-Jaque, L.R. Forrest, S. Schuldiner. Hebrew University, Israel and National Institutes of Health. B486 629.8 Different Lipids in Synaptic Vesicle and Synaptosome Membrane. K.T. Lewis, K.R. Maddipati, A.R. Naik, B.P. Jena. Wayne State University. B487 629.9 Control of PI4P Turnover by Endogenous OSBP for Fast Cholesterol Transport at Membrane Contact Sites. B. Mesmin, J. Bigay, J. Polidori, S. Lacas-Gervais, B. Antonny. Institut de Pharmacologie Moléculaire et Cellulaire— CNRS, France and Université Nice Sophia Antipolis, France. B488 629.10 Lipoprotein Lipase Regulates the Expression of Genes Responsible for Cellular Cholesterol Uptake and Efflux in Human and Mouse Macrophages. K. Moctar, K.R. Madhwani, A.J. Kim, J.D. Medh. California State University Northridge. B489 629.11 Cardiolipin Content Has a Stronger Influence Than Acyl Chain Composition on Select Membrane Properties of Biomimetic Mitochondrial Membranes. E.R. Pennington, A. Fix, E.M. Sullivan, A. Kennedy, D.A. Brown, T.N. Zeczycki, S.R. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, East Carolina University and Virginia Tech Corporate Research Center.
SUNDAY BIOCHEMISTRY B490 629.12 Lysosome Enlargement in PIKfyve Inhibited Cells Proceeds Through Homotypic Lysosome Fusion Rather Than Growth of Individual Lysosomes. G. Saffi. Ryerson University, Canada. B491 629.13 Characterization of Kinetic Parameters of the Lysophospholipase PldB Using a Liquid Chromatography Mass Spectrometry Based in Vitro Assay. G. Elizalde, T.A. Garrett. Vassar College. B492 629.14 Impact of Altering the Headgroup-Acylated Glycerophospholipid Levels on Escherichia coli Cells Deficient in Phosphatidylserine and Phosphatidylethanolamine. O. Oke, T.A. Garrett. Vassar College. B493 629.15 Styrene-Maleic Acid (SMA) Nanodisc Technology: A Novel Approach for Isolation and Purification of the Infectious Prion Protein (PrPSc) M. Esmaili, X. Wang, B. Tancowny, H. Wille, M. Overduin. University of Alberta, Canada. B494 629.16 Tracking the Flow of Carbon Toward Oil Synthesis in an Emerging Crop Lesquerella (Physaria fendleri). J. Cocuron, E. Tsogtbaatar, A. Alonso. The Ohio State University. B495 629.17 Stereochemical Characterization of AcylPhosphatidylglycerol and bis-(Monoacylglycerol)Phosphate Using Nuclear Magnetic Resonance. C.S. Peros, T.A. Garrett. Vassar College. B496 629.18 Withdrawn. B497 629.19 Modulation of Endothelial Membrane Biomechanics by Oxidized Phospholipids: A Combined Experimental and Computational Approach. M.A. Ayee, E. LeMaster, T. Shentu, N. Barbera, B.S. Akpa, I. Levitan. University of Illinois at Chicago and North Carolina State University. B498 629.20 Probing the Lipid Composition at the Site of Influenza Virus Assembly and Budding with High-Resolution SIMS. M.L. Kraft, A.N. Yeager, P.K. Weber, J. Zimmerberg. University of Illinois at Urbana-Champaign, Lawrence Livermore National Laboratory, National Institute of Child Health and Human Development, National Institutes of Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development. B499 629.21 Phosphorylation of the Glycerol 3-Phosphate Acyltransferase Gpt2 Regulates the Timing of TAG Mobilization upon Growth Resumption. M. Tavassoli, B. Nagler, B. Shabits, A. Lopez-Villalobos, K. Athenstaedt, V. Zaremberg. University of Calgary, Canada, and Institute of Molecular Biosciences, Austria. B500 629.22 Substrate Specificity and Unusual Reaction Mechanism of the Sterol 4-Methyltransferase in Caenorhabdtis elegans. P.M. Fisher, W. Zhou, M.B. Miller, Y. Shen, H. Shi, W.D. Nes. Texas Tech University. B501 629.23 Liver X Receptor (LXR) Activation Decreases Chronic Myelogenous Leukemia Cell Viability and Alters the Expression of Antiapoptotic and Cholesterol Genes. C.J. Andersen, L. Dupree, A. Doerr, L. Cintron-Rivera, K. Murray, N. Ragonesi. Fairfield University. B502 629.24 Ceramide-1-Phosphate: Characterizing a Fluorescent Lipid and Discovering New Binding Proteins. C.M. Shirey, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend.
B503 629.25 Identification of Sphingolipid Metabolism Perturbations in Endothelial Cells Induced by the Acid Sphingomyelinase Inhibitor Imipramine Using Stable Isotope Labeling and Targeted Lipidomics. E. Berdyshev, M.J. Justice, I. Bronova, K.S. Schweitzer, I. Petrache. National Jewish Health. B504 629.26 Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. F.G. Tafesse. Oregon Health & Science University (OHSU). B505 629.27 PKC-δ Mediates Sphk2 Activation and Histone Acetylation in Pseudomonas aeruginosa-Induced Lung Inflammation. D.L. Ebenezer, P. Fu, A.W. Ha, V. Natarajan. University of Illinois at Chicago. B506 629.28 A Prokaryotic-Like Lysophosphatidic Acid Acyltransferase Reveals Unique Features of Triacylglycerol Biosynthesis in Microalgae. Y. Kim, E.L. Terng, W. Riekhof, E.B. Cahoon, H. Cerutti. University of Nebraska-Lincoln. B507 629.29 Study of Resistance to Abyotic Factors Through Oxidative Stress Biomarkers in Kluyveromyces Yeast. B.Vargas Ochoa, J.A. Mejía-Barajas, M. Arellano-Plaza, R. MontoyaPérez, A. Saavedra-Molina. Universidad Michoacana de San Nicolás de Hidalgo, Mexico, Universidad Michoacana de San Nicolás de Hidalgo, Mexico and CIATEJ, Mexico. B508 629.30 Characterizing Lipid Production in Chlorella vulgaris Exposed to Sethoxydim, an Acetyl-CoA Carboxylase Inhibitor. A.L. Smythers, A.T. Holland, A. Roberts, D.R. Kolling. Marshall University.
630. MEMBRANE PROTEINS AND LIPID INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F
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Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B509 630.1 Investigating Phospholipid Binding Residues in the C Terminus of Ebola Virus Matrix Protein, V. P40 M. Budicini, K. Johnson, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend. B510 630.2 Ceramide Induced Regulated Alternative Translocation of TM4SF20 and Beyond. B. Denard, Q. Chen, C. Lee, S. Han, J. Ye, J. Ye. UT Southwestern Medical Center. B511 630.3 Structural Mechanism of Viral Tethering by the Anti-Viral Protein BST-2 K. Ozcan, C. Berndsen. James Madison University. B512 630.4 Small Molecule and Lipid Binding Mechanisms of Sortilin and Vps10 Indicated in Altered Trafficking Patterns and Membrane Fusion. R. Sparks, R.A. Fratti. University of Illinois at Urbana-Champaign. B513 630.5 The Ebola Virus Matrix Protein and Membrane Fluidity. K.A. Johnson, R.V. Stahelin. Notre Dame and IU School of Medicine. B514 630.6 Membrane Localization of Metabolic Enzyme and Metabolic Modulation in the Δmin Mutant of Escherichia coli. Y. Shih, C. Hung, C. Wang. Academia Sinica, Taiwan and National Taiwan University, Taiwan.
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BIOCHEMISTRY SUNDAY B515 630.7 Studying the Effect of Negative Curvature on Amphipathic α-Helix Model Protein Binding to an Oil/ Buffer Interface. M. Mirheydari, E. Mann, E. Kooijman. Kent State University. B516 630.8 Effectiveness of Sub-Therapeutic Staurosporine on Inhibition of Budding and Replication of Lipid-Enveloped Viruses. M. Fraser, R. Stahelin. University of Notre Dame and Indiana University School of Medicine—South Bend. B517 630.9 Hydrophobic Region of Marburg Virus May Indicate Mechanism of Protein Trafficking to Plasma Membrane. K. Wijesinghe, L. McVeigh, R. Stahelin. University of Notre Dame. B518 630.10 Targeting Lipid Metabolism to Inhibit Ebola VP40 Mediated Viral Budding. M.L. Husby, R. Stahelin. University of Notre Dame and Indiana University School of Medicine. B519 630.11 Stronger Together: The Role of Cysteine Residues in Ebola Viral Matrix Protein V. P40. S.B. Baker, K. Johnson, R. Stahelin. University of Notre Dame, Indiana University School of Medicine and South Bend. B520 630.12 Interaction Between a 70-kDa Heat Shock Protein and Phosphatidylserine in Stressed Human Cells. A.D. Bilog, C. Labanieh, N. Nikolaidis. California State University at Fullerton. B521 630.13 Crystal Structure of Lysophosphatidic Acid Acyltransferase Reveals a Paired Reentrant Helix Membrane Anchor That Positions the Active Site Inside the Phospholipid Bilayer. S.W. White, R.M. Robertson, J. Yao, S. Gajewski, G. Kumar, C.O. Rock. St. Jude Children’s Research Hospital. B522 630.14 Binding Interaction of Lipid-Bound ApoA–I with Lipopolysaccharides and Phosphatidylglycerol. B. Haeri, P. Weers. California State University at Long Beach. B523 630.15 Understanding Ethanol Hexanoyl Transferase (Eht1) Localization to Lipid Droplets and the Endoplasmic Reticulum in Saccharomyces cerevisiae. J. Zhu, I. Wheeldon. University of California at Riverside. B524 630.16 Diacylglycerolpyrophosphate and Phosphatidic Acid Related Much? P. Putta, E. Creque, E.E. Kooijman. Kent State University. B525 630.17 Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection. F. Lu, M. Brown, J. Goldstein. University of Texas Southwestern Medical Center. B526 630.18 Phosphatidylinositol 3,5-Bisphosphate Acts as a Novel Regulator of Calcium Transport During Saccharomyces cerevisiae Vacuolar Fusion. G.E. Miner, R.A. Fratti. University of Illinois at Urbana-Champaign. B527 630.19 Organelle-Specific Regulation of V-ATPase Activity by Inositol Phospholipids. P.M. Kane, S. Banerjee. SUNY Upstate Medical University. B528 630.20 Computational Modeling of Human Fatty Acid Transport Protein 2. V.M. Perez, B.L. Puniya, T. Helikar, C.C. DiRusso, P.N. Black. University of Nebraska-Lincoln.
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631. CELL AND ORGANELLE DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B529 631.1 Dissecting Comorbidity Between Parkinson’s Disease and Melanoma in a Cell Culture Model. D. Dele-Oni, A. Bose, G. Petsko. University of Massachusetts Dartmouth and Weill Cornell Medicine. B530 631.2 Stressing Interdisciplinarity to Mold the Undergraduate Experience. C.M. Keller, B.E. Bridges, J.N. Roney, D.R. Dries. Juniata College. B531 631.3 Syntaphilin Regulates Mitochondrial Dynamics and Tumor Cell Invasion. M. Caino, D.C. Altieri. The Wistar Institute.
632. NUCLEAR DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B532 632.1 Investigating the Spatiotemporal Distribution Patterns of PCID2 Between the Nucleus and the Centrosome. R.K. Flores, K.K. Resendes. Westminster College. B533 632.2 The Disruption of Nuclear Export and Protein Localization with 5-Fluorouracil. A. Nickle, M. Bischak, K. Higby, K.K. Resendes. Westminster College.
SUNDAY BIOCHEMISTRY
633. ENDOPLASMIC RETICULUM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B534 633.1 The Yeast Homolog of the Mammalian Oncogene, Bax Inhibitor-1, Regulates the Unfolded Protein Response by Altering the ER Microenvironment. S. Benko, D. Eagan, J. Alisch, M. Brown, M. McCarthy, W. Cavedon, J. O’Brien, L. Ritzer, B. Berry, N. Austriaco. Providence College. B535 633.2 Host Control of Gag Localization in a Yeast Retrotransposon System. K.L. McGlone, J.B. Keeney. Juniata College. B536 633.3 Clustering of IRE1α in the Mammalian ER Membrane Is Independent of Its Enzymatic Activities. D. Ricci, I. Marroco, J. Vargas, D. Eletto, M. Dibos, S. Boyle, Y. Iwamoto, Y. Argon. Children’s Hospital of Philadelphia, University of Pennsylvania, Sapienza University of Rome, and University of Salerno. B537 633.4 ER Stress and Molecular Targets of Platinum Anticancer Compounds. R. Cunningham, V. DeRose. University of Oregon.
634. MITOCHONDRIA IN HEALTH AND DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B538 634.1 AMPK Negatively Regulates Mitophagy in the Heart. A. Kaminaris, S. Kobayashi, G. McStay, Q. Liang. New York Institute of Technology College of Osteopathic Medicine. B539 634.2 Effects of Deceased Mitochondrial Ca2+ Uptake in an in Vitro Model of Parkinson’s Disease. N. de la Rosa-González, A. Lee, M. Joiner. University of Puerto Rico at Ponce and University of Iowa.
B540 634.3 Cardiac Mitochondrial Phospholipid Acyl Chains Are Remodeled in Murine Obesity but Do Not Impair Supercomplex Formation, Respiratory Enzyme Activity, or Respiration. E.M. Sullivan, A. Fix, M.J. Crouch, G.C. Sparagna, T.N. Zeczycki, D.A. Brown, S.R. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, East Carolina University, University of Colorado Denver Anschutz Medical Campus and Virginia Polytechnic Institute. B541 634.4 Functional Insights on the Human Adenine Nucleotide Translocator Interactome. M. Acoba, Y. Lu, S. Kandasamy, T. Huang, R. Nirujogi, A. Pandey, S.M. Claypool. Johns Hopkins University School of Medicine and National Taiwan University Hospital and National Taiwan University Cancer Center, Taiwan. B542 634.5 Overexpression of Manganese Superoxide Dismutase in Mouse Liver Leads to Defects in Oxidative Phosphorylation. S. Steyl. Appalachian State University. B543 634.6 Analysis of Oct1p/MIPEP Proteolytic Processing of Coenzyme Q Biosynthesis Proteins. M.J. Drahnak, M.T. Veling, D.J. Pagliarini. Morgridge Institute for Research and University of Wisconsin-Madison. B544 634.7 Single, Long Molecule PCR for the Detection of Rare Mutations in Mitochondrial DNA. H. Li, S. Annis, D. Woods, J. Tilly, K. Khrapko. Northeastern University. B545 634.8 Fis1 Activity in Pre- and Post-Assembly of the Yeast Mitochondrial Fission Machinery. M.C. Harwig, R.B. Hill. Medical College of Wisconsin. B546 634.9 A Potential Role for Mitochondrial Ca2+ Uptake During B Cell Activation. A. Torres-Quintanilla, E. GonzálezCastillo, G. García-Rivas. Tecnológico de Monterrey, Mexico. B547 634.10 Withdrawn. B548 634.11 Identification of Regulators of Lysosome Formation. G.T. Le, N. Jackson, N. Shaikh, A. Shearon, H. Fares. University of Arizona. B549 634.12 Monitoring Organelle-Specific Responses to Amphotericin B in Mammalian Cells and Candida albicans Biofilms. C. Tourville, G. Rigden, D. Lewis, S. Hartsel. University of Wisconsin-Eau Claire.
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Nutrition 635. BIOAVAILABILITY AND METABOLISM OF CAROTENOIDS AND VITAMIN A Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C1 I 635.1 The Impact of Early Postnatal Vitamin a Supplementation on Childhood Obesity Risk—A Study in Rat Model. C. Wei, A.L. Weaver, C.J. Rogers, A. Ross. The Pennsylvania State University. C2 II 635.2 Carotenoid-Mediated Protection of Human Retinal Pigment Epithelial Cells Against Hypoxic Stress. C. Draper, G.S. Allison, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center. C3 I 635.3 Low Plasma Carotene Concentrations Are Associated with an Increased Risk of Acute Coronary Syndrome in a Korean Population. J. So, M.E. Walker, N.R. Matthan, A.H. Lichtenstein, S.N. Han, I. Chung, E.J. Johnson. Tufts University Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Seoul National University, Republic of Korea, Ewha Womans University, Republic of Korea. C4 II 635.4 Tomato Based Supplement Protects Skin from UV Damage and Photo-Aging Processes. K. Linnewiel Hermoni, G. Raz. Lycored. C5 I 635.5 Retention of Provitamin a Carotenoids in High-Provitamin a Biofortified Maize and Eggs After Various Cooking Methods. M. Sowa, S. Goltz, S.A. Tanumihardjo. University of Wisconsin—Madison. C6 II 635.6 Application of a High-Performance Liquid Chromatography Method for the Evaluation of NonProvitamin A Carotenoids. T.J. Titcomb, C.R. Davis, S.A. Tanumihardjo. UW Madison. C7 I 635.7 Light and Antibiotic Stress Factor in the Accumulation of Carotenoid Pigments in Green Microalgae Isolate. O. Oyebamiji, A. Adeoso. University of Lagos, Nigeria and Yaba College of Technology, Nigeria. C8 II 635.8 Efficacy of Lycopene to Prevent Against Atrazine-Induced Cardiotoxicity via Modulation of Nitric Oxide and Inflammatory NF-κB Pathways. X. Li, J. Lin, L. Qin, J. Xia, S. Zhu, J. Li. Northeast Agricultural University, People’s Republic of China, Qiqihar Medical University, People’s Republic of China. C9 I 635.9 Neuroprotective Effects of Lutein in Neonatal Hypoxic-Ischemic Brain Injury. C.H. Foster, D. Sambalingam, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center. C10 II 635.10 Impact of Acute Dietary Vitamin a Intake on the Measured Variable (Plasma Retinol Specific Activity) Used in Prediction of Total Body Vitamin a Stores by Retinol Isotope Dilution. J.L. Ford, J.B. Green, M.H. Green. Pennsylvania State University. C11 I 635.11 Hepatic Uptake of Vitamin a Is Independent of Retinoic Acid Pretreatment in Neonatal Rats. Y. Li, M.H. Green, L. Tan, A. Ross. The Pennsylvania State University and The University of Alabama.
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C12 II 635.12 A Plasma Proteome Is Associated with Carotenoid Status in Young Nepalese Children. A. Eroglu, K.J. Schulze, R.N. Cole, P. Christian, B.A. Nonyane, S.E. Lee, L.S. Wu, S. Khatry, K.P. West; Jr. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine and John Hopkins Bloomberg School of Public Health. C13 I 635.13 Carotenoids and Apo-Carotenoids in Human Plasma After Continued Consumption of High β-Carotene or High Lycopene Tomato Juice. J.L. Cooperstone, K.M. Riedl, M.J. Cichon, D.M. Francis, R.W. Curley Jr., S.J. Schwartz, J.A. Novotny, E.H. Harrison. The Ohio State University and USDA Beltsville Human Nutrition Research Center. C14 II 635.14 Obesity Leads to Tissue, but Not Serum Vitamin A Deficiency. S.E. Trasino, X. Tang, J. Jessurn, L.J. Gudas. Hunter College and Weill Cornell Medical College. C15 I 635.15 Superior Oral Bioavailability in Beagle Dogs of Lutein Derived from a Novel Manufacturing Process. G.D. Sunvold, K. Brandt, D. Ribera, A. Lazaar, K.J. Wedekind, R. Torras, G. Guirado, J.L. Evans, G. Reznick, G. Castells. Novus International, Novus International, Spain, Isoquimen SL, Spain and Universitat Autonòma de Barcelona, Spain. C16 II 635.16 Bioaccessibility and Intestinal Cell Uptake of Astaxanthin from Salmon and Commercial Supplements. C. Chitchumroonchokchai, M.L. Failla. The Ohio State University. C17 I 635.17 Vitamin A Intake of School-Aged Children Exceed Dietary References Intake in the Western Highlands of Guatemala. M.L. Escobar, M. Vossenaar, N.W. Solomons. CeSSIAM, Guatemala. C18 II 635.18 Uptake and Metabolism of Dietary β-Apocarotenoids by Caco-2 Intestinal Cells. B.O. Durojaye, K.M. Riedl, R.W. Curley, E. Harrison. Ohio State University.
636. NEUROBIOLOGY, MOOD AND BEHAVIOR Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C19 I 636.1 An Open Label Study to Evaluate the Effect of Kaempferia parviflora in Support of Erectile Function and Male Sexual Health Among Overall Healthy Males 50–70. S. Hirsh, L. Huber, R. Stein, K. Schmid, A. Swick, S. Joyal. Life Extension Clinical Research, Inc. and Life Extension. C20 II 636.2 Bipolar Disorder in Youth Is Associated with Increased Low Molecular Weight Fraction of Vitamin D Binding Protein. B. Petrov, A. Aldoori, C. James, K. Yang, G.P. Algorta, A. Samogyi, R. Al Awadhi, E. Arnold, M. Fristad, B. Gracious, O. Ziouzenkova. The Ohio State University, Lancaster University, United Kingdom, Royal College of Surgeons in Ireland, Ireland and Nationwide Children’s Hospital.
SUNDAY NUTRITION C21 I 636.3 A Randomized Double-Blind, Placebo Controlled, Four-Arm Parallel Study Investigating the Effect of a Broad Spectrum Wellness Beverage on Mood State in Healthy, Moderately Stressed Adults. O. Aruoma, M. Evans, J. Anthony, N. Guthrie, B. Landes. University of Long Beach, KGK Synergize Inc, Canada and Nutritional Products Consulting Group. C22 II 636.4 α-Tocotrienol Protects Primary Hippocampal Neurons Against Oxidative Stress-Mediated ΔNBcl-xL Formation in the Mitochondria. H. Park, E.A. Jonas. Yale School of Medicine. C23 I 636.5 12 Weeks of Eating Almonds on Cognitive Function and Cardiometabolic Biomarkers—A Study Protocol. A. Coates, S. Morgillo, C. Yandell, A. Scholey, J. Buckley, A. Hill. University of South Australia, Australia and Swinburne University, Australia. C24 II 636.6 Healthy Profits: An Interdisciplinary Retail Framework for Increasing the Sales of Healthy Foods. B. Wansink. Cornell University. C25 I 636.7 Effects of Hydration on Relational Memory Among Preadolescent Children. D.R. Westfall, K.M. Hassevoort, S. Barnett, A.R. Covello, J.H. Bottin, E.T. Perrier, N.J. Cohen, C.H. Hillman, N.A. Khan. Northeastern University, University of Illinois, Washington State University and Danone Research, France. C26 II 636.8 The Omega-6 to Omega-3 Fatty Acid Ratio Predicts Brain Activity During Planning Tasks in Middle Childhood. K. Sheppard, C.L. Cheatham. The Research Institute at Nationwide Children’s Hospital and University of North Carolina at Chapel Hill. C27 I 636.9 Is It Exercise or a Scenic Walk? Reframing Physical Activity as Fun Leads to Reduced Calorie Compensation, Healthier Meals, and Less Snacking. B. Wansink, C.O. Werle. Cornell University and Grenoble Ecole de Management, France. C28 II 636.10 High Fat Diet Induces Gender-Specific Differential Gene Expression in Drosophila melanogaster Brain. T. Stobdan, P. Azad, E. Heinrichsen, D. Sahoo, I. Hartley, D. Zhou, G.G. Haddad. Univ of California San Diego and Rady Children’s Hospital. C29 I 636.11 The Role of N-Acetylcysteine and 3H-1,2-Dithiole-3-Thione in Maintaining Glutathione Status and Protection Against Advanced Glycation End Product Induced Neurite Degeneration in SH-SY5Y Cells. M.A. Stochelski, T. Wilmanski, J.R. Burgess. Purdue University. C30 II 636.12 Vitamin D Receptor and Megalin Gene Polymorphisms Are Associated with Longitudinal Cognitive Change Among African-American Urban Adults. M.A. Beydoun, S.M. Tajuddin, G.A. Dore, J.A. Canas, H.A. Beydoun, M.K. Evans, A.B. Zonderman. National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Nemours Clinic, Johns Hopkins Medical Institutions and Johns Hopkins University. C31 I 636.13 Dietary Screening Tool Used to Describe Diet Quality in Acquired Brain Injury and Parkinson’s Disease: An Exploratory Study. D.L. LoBuono, L. Hurley, M.J. Delmonico, F. Xu, L. Mahler, I.E. Lofgren. University of Rhode Island.
C32 II 636.14 Effects of Potatoes and Other Carbohydrates Consumed at Breakfast on Cognition, Glycemia and Satiety in Children. J.J. Lee, V.C. Wong, S. Cleary, J. Totosy de Zepetnek, A.J. Fiocco, N. Bellissimo. Ryerson University, Canada. C33 I 636.15 Evaluation of the Association of Toll-Like Receptor 4 and BMI with Postpartum Depressive Symptomatology. B.A. Molkenthin, M.P. Judge, E.E. Young, C.T. Beck. University of Connecticut. C34 II 636.16 Neuroprotective Effect of Rg5/rk1 Against Thermal Stress-Exposed Damage of Hippocampal Cell Line HT-22. S. Choi, J. Song, S. Chei, E. Koh, J. Choi, Y. Seo, M. Park, J. Hwang, Y. Lee, B. Yang, J. Park, B. Lee. CHA University, Republic of Korea, Chung-Ang University, Republic of Korea, Korean Ginseng Research Co., Ltd., Republic of Korea. C35 I 636.17 Neuroprotective Effect of Spirulina Maxima Extract Against Trimethyltin-Induced Neuronal Damage in HT-22 Cells. s. Chei, E. Koh, Y. Seo, J. Choi, Y. Lee, J. Hwang, J. Song, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea. C36 II 636.18 Spirulina maxima Extract Protects Against TMT-Induced Cognitive Disorder in SH-SY5Y Cells. S. Chei, Y. Seo, E. Koh, J. choi, J. Hwang, Y. lee, J. Song, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea. C37 I 636.19 Modulation of Protein Status in Humans Leads to Preference for Increased Portions. O. Davidenko, S. Fromentin, P. Barbillon, G. Fromentin, D. Tomé, N. Darcel. UMR 914 Physiology of Nutrition and Ingestibe Behavior— AgroParisTech, INRA, Paris-Saclay, France, UMR MIA and INRA AgroParisTech Universite? Paris-Saclay, France. C38 II 636.20 Consumption of a 4-Week, Carbohydrate-Restricted Diet Improves Food Intake Motivation in Overweight Subjects. N.T. Le, Q. Hu, M.M. Syed Abdul, C. Heimowitz, E.J. Parks. University of Missouri and Atkins Nutritionals. C39 I 636.21 Adequate Hydration and Sleep Support Pre-Test Cognitive Performance in College Students. B. Beezhold, C. Radnitz, J. Dalrymple, A. Feldman, L. Todd, F. Fatima, C. Filbin, R. Fritz, E. Gerlach, P. Gulling, E. Walker. Benedictine University and Fairleigh Dickinson University. C40 II 636.22 Early Life Diet Alters Sleep Architecture Following an Acute Stress: The Potential Role of Milk Oligosaccharides. M. Chichlowski, S. Morairty, B.M. Berg. Mead Johnson Pediatric Nutrition Institute and SRI International. C41 I 636.23 Is Chocolate Beneficial for Brain Health? Dark Chocolate (70% Cacao) Increases Brain EEG Power Spectral Density (μV2) Gamma Wave Frequency (31–40 Hz), Which Is Associated with Enhanced Cognitive Processing, Learning, Memory, Recall, Neural Synchrony and Mindfulness Meditation. L. Berk, E. Lohman, G. Bains, K. Bruhjell, J. Bradburn, N. Vijayan, S. More. Loma Linda University.
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NUTRITION SUNDAY C42 II 636.24 Nuts and Brain Health: Nuts Increase EEG Power Spectral Density (μV²) for Delta Frequency (1–3 Hz) and Gamma Frequency (31–40 Hz) Associated with Deep Meditation, Empathy, Healing, as Well as Neural Synchronization, Enhanced Cognitive Processing, Recall, and Memory All Beneficial for Brain Health. L. Berk, E. Lohman, G. Bains, K. Bruhjell, J. Bradburn, N. Vijayan, S. More, K. Patel, S. Dhuri, S. Mourya, G. Park, A. Gujaran, S. Nikam. Loma Linda University. C43 I 636.25 1,25(OH)2D3 Protects SH-SY5Y Human Neuroblastoma Through Decreasing Aβ Toxicity and Reducing Tau Protein Hyperphosphorylation. H. Liao, Y. Chang, S. Lin. School of Nutrition and Health Sciences, Taipei Medical University, Taiwan and School of Nutrition and Health Sciences, Taiwan. C44 II 636.26 A Possible Emerging Role of Stachys siedlbodii MIQ Extract in Neuroprotection: In Vitro and in Vivo V.A. Ravichandran, M. Kim, Y. Cha. Chonbuk National University, Republic of Korea. C45 I 636.27 Migraine as a Metabolic Disease. A.A. Stanton. independent researcher. C46 II 636.28 Relationship Between Whole Grain Consumption and Selective Attention. J. Evensen, C. Edwards, S. Thompson, H. Holscher, N. Khan. University of Illinois at Urbana Champaign. C47 I 636.29 Seedy Business: Adding Healthy Additives Transforms Indulgence to Health Food in Consumers’ Minds. A. Tal, B. Wansink. Cornell University. C48 II 636.30 Why Kids Should Play with Their Phone During Dinner: Active Engagement Can Decrease Food Consumption. A. Tal, B. Wansink. Cornell University. C49 I 636.31 Serve Yourself from Overeating: PreServed Portions Lead to Uniform Eating Across Distraction Levels. A. Tal, B. Wansink. Cornell University. C50 II 636.32 More of a Bad Thing: How Consumers Ignore Pollutant Levels. A. Tal, B. Wansink. Cornell University. C51 I 636.33 Limited Access to a Palatable High Fat Diet Promotes Binge-Like Food Intake and Addiction-Like Dopamine Terminal Adaptations in the Nucleus Accumbens Core of Mice. S. Fordahl, S. Jones. Wake Forest School of Medicine and University of North Carolina at Greensboro. C52 II 636.34 Sustained Exposure to High-Sucrose Diet Triggers Endoplasmic Reticulum Stress in Hippocampus and Anticipates Cognitive and Motor Impairments in Adults Rats. B.A. Pinto, T.M. Melo, K.F. Flister, L.M. França, D. Kajihara, V.R. Moreira, S.R. Pereira, F.R. Laurindo, A.M. Paes. UFMA, Brazil and Heart Institute of the School of Medicine, Brazil. C53 I 636.35 Relationship Between Polyphenol Consumption and Physical Activity and Sleep. S. Grobe, J. teRiele, R. Martin, A. Boolani. Clarkson University. C54 II 636.36 Dietary Fatty Acids and Associated with Anxiety and Depression in Older Adults. J. Luo, S.C. Chai, B.H. Arjmandi. University of Delaware and Florida State University. C55 I 636.37 A Ketogenic Diet Prevents Abnormal Changes in Peripheral Nerve Function Caused by a High-Fat Diet. M. Cooper, J. Ryals, D. Wright. University of Kansas Medical Center.
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C56 II 636.38 Serum Endocannabinoids in the Luteal Phase of the Menstrual Cycle Are Associated with Leptin and Food Cravings. S. Krishnan, K. Agrawal, R.R. Tryon, L.C. Welch, W.F. Horn, J.W. Newman, N.L. Keim. University of California, Davis and USDA-WHNRC. C57 I 636.39 Acute Effects of Wild Blueberry Intake on Metabolic Markers and Cognitive Performance in MiddleAged Adults. S. Rahman, A. Whyte, Y. Huang, C. Williams, R. Krikorian, B. Burton-Freeman. Illinois Institute of Technology, University of Reading, United Kingdom and University of Cincinnati Academic Health Center. C58 II 636.40 Intake of Nutrients Among Individuals at Risk for Suicide Enrolled in the Better Resiliency Among Veterans and Non-Veterans with Omega-3’s (BRAVO) Clinical Trial. K.B. Johnson, B.P. Marriott, J.C. Newman, B. Team. Medical University of South Carolina. C59 I 636.41 Relationship Between Severity of Depression and Alcohol and/or Tobacco Use Among Adults with Type 2 Diabetes. N. Shaikh, S. Poongothai, M. Ali, L. Chwastiak, V. Mohan. National Institutes of Health, Madras Diabetes Research Foundation, India, Emory University and University of Washington.
637. TRACE ELEMENT TRANSPORT AND HOMEOSTASIS IN HEALTH AND DISEASE Poster (Sponsored by: Vitamins and Minerals RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C60 I 637.1 Increasing Dietary Iron Intake Perturbs Copper Metabolism in a Dose-Dependent Fashion in Growing Sprague-Dawley Rats. J. Ha, C. Doguer, S.R. Flores, T. Wang, S. Jeong, J.F. Collins. University of Florida. C61 II 637.2 Prolonged High Altitude Exposure Results in Elevated Erythroferrone and Diminished Hepcidin Levels in Healthy Young Male Volunteers. J.P. McClung, S.R. Hennigar, C.E. Berryman, A.J. Young, S.M. Pasiakos. US Army Research Institute of Environmental Medicine. C62 I 637.3 Copper-Induced Reversal of Fibrosis in Rat Model of Cardiac Hypertrophy Is Associated with Enhanced Collagen Degradation by MMP-2 Up-Regulation. Y. Liu, Y. Xiao, J. Liu, P. Han, L. Feng, Y. Kang. Regenerative Medicine Research Center, West China Hospital, Sichuan University, People’s Republic of China, and University of Louisville School of Medicine. C63 II 637.4 The Loss of Copper and the Increase in COMMD-1 in Ischemic Hearts of Mice. K. Li, C. Li, S. Hu, C. Fu, Y. Kang. Regenerative Medicine Research Center West China Hospital Sichuan University, People’s Republic of China, Department of Pharmacology and Toxicology and University of Louisville. C64 I 637.5 Regression of Pressure OverloadInduced Cardiac Hypertrophy by Trientine-Induced Copper Redistribution to the Heart in Rats. J. Liu, Y. Liu, C. Fu, Y. Xiao, Q. Feng, S. Fan, X. Ding, L. Qiu, P. Han, Y. Kang. Sichuan University, People’s Republic of China, and University of Louisville School of Medicine.
SUNDAY NUTRITION C65 II 637.6 Characterization of a Hepcidin Knockout Rat, a Novel Model of Iron Overload. S.R. Flores, X. Wang, J. Ha, C. Doguer, T. Wang, J.F. Collins. University of Florida. C66 I 637.7 Lack of Intestinal Divalent Metal-Ion Transporter 1 (DMT1) Impairs Copper Absorption in Female Mice. X. Wang, S.R. Flores, J. Ha, C. Doguer, T. Wang, J. Collins. University of Florida. C67 II 637.8 Loss of ZIP12 Leads to Mitochondrial Dysfunction and Reduced Neurite Outgrowth in Neuro-2A Neuroblastoma Cells. T.Z. Tang, M.D. Hart, M.R. Nacke, L. Wu, J.L. Fiddler, S.L. Clarke, B.J. Smith, D. Lin, W. Chowanadisai. Oklahoma State University. C68 I 637.9 Zinc and Copper in Oral Submucous Fibrosis. P.K. Sachdev, J. Freeland-Graves, N.S. Beretvas, N. Sanjeevi. The University of Texas at Austin. C69 II 637.10 Quantifying the Association Between Acute Leukemia and Serum Zinc, Copper, and Selenium. S. Kim, M. Babaei, P.K. Sachdev, N. Beretvas, J.H. FreelandGraves. The University of Texas at Austin. C70 I 637.11 Hepcidin-Dependent Iron Mobilization Is Required for White to Beige Adipocyte Conversion. J. Kim, G. Ozaki, M. Okla, J. Lee, S. Chung. University of Nebraska Lincoln.
638. MICRONUTRIENT INTERVENTIONS
C72 II 638.2 Nature of the Proposed AntiHyperglycemic Chromium(III) Malate. J.B. Vincent, M. Smart, H. Tannehill, S. Brown. The University of Alabama. C73 I 638.3 Micro-Nutrient Supplementation Affects Mood Depending on Dopamine and Serotonin Single Nucleotide Polymorphisms Associated with Psychiatric Symptoms. D. Benton, S. Long, H.A. Young. Swansea University, United Kingdom and Cardiff University, United Kingdom. C74 II 638.4 Differential Effects of 1,25D3-MARRS Expression on Mammary Gland Growth and Development Depend on the Vitamin D3 Dose. A. Wilkin, T. Trinh, M. Edson, K. Meckling. University of Guelph, Canada. C75 I 638.5 Efficacy of Various Vitamin D Correction Strategies in Saudi Adults and Children. N. Al-Daghri, S. AbdAlrahman, Y. Al-Saleh, N. Aljohani, O. Al-Attas, M. Alokail. King Saud University, Saudi Arabia, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia and King Fahad Medical City, Saudi Arabia. C76 II 638.6 Improvement in Fatigue, Quality of Life and Cognitive Function Following Oral Iron Supplementation for Treatment of Iron Deficiency in Patients Who Have Had Bariatric Surgery. N. Gletsu Miller, R.A. Mischler, S.M. Armah, T. Redick, A.D. Rosen, J.N. Choi. Purdue University, University of North Carolina at Greensboro and Indiana University.
639. GLOBAL NUTRITION I
Poster (Sponsored by: Vitamins and Minerals RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C71 I 638.1 Modifiers of the Effect of Maternal Multiple Micronutrient Supplementation: An Individual Patient Data MetaAnalysis of 17 Randomized Trials. E.R. Smith, A. Shankar, L. Wu, S. Aboud, S. Adu-Afarwuah, H. Ali, M. Apriatni, S. Arifeen, P. Ashorn, Z.A. Bhutta, P. Christian, D. Devakumar, K.G. Dewey, H. Friis, E. Gomo, P. Gupta, P. Kæstel, P. Kolsteren, H. Lanou, K. Maleta, A. Mamadoultaibou, G. Msamanga, D. Osrin, L. Persson, U. Ramakrishnan, J.A. Rivera, A. Rizvi, H. Sachdev, W. Urassa, K.P. West, N. Zagre, L. Zeng, W. Fawzi, C. Sudfeld. Boston Children’s Hospital, Harvard T.H. Chan School of Public Health, Johns Hopkins Bloomberg School of Public Health, Muhimbili University of Health and Allied Sciences, Tanzania, University of Ghana, Legon, Ghana, Johns Hopkins University in Bangladesh, Bangladesh, SUMMIT Institute of Development, Indonesia, ICDDR,, Bangladesh, University of Tampere School of Medicine, Finland, The Aga Khan University, Pakistan, Hospital for Sick Children, Canada, UCL Institute for Global Health, United Kingdom, University of California-Davis, University of Copenhagen, Denmark, University of Zimbabwe, Zimbabwe, University College of Medical Sciences, India, Prince Leopold Institute of Tropical Medicine, Belgium, Institut de Recherche en Sciences de la Santé, Burkina Faso, School of Public Health and Family Medicine, University of Malawi College of Medicine, Malawi, Food and Agriculture Organization of the United Nations, Gabon, Uppsala University, Sweden, Rollins School of Public Health, Emory University, Instituto Nacional de Salud Publica, Mexico, Sitaram Bhartia Institute of Science and Research, India, UNICEF Regional Office for West and Central Africa, Senegal, Xi’an Jiaotong University College of Medicine, and People’s Republic of China.
Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C77 I 639.1 Body-Segment Profile in MidLife Women Residents in Quetzaltenango, Guatemala: A Perspective on Stunting in Adulthood. M. Gopal, M. Escobar, R. García-Meza, N.W. Solomons, O.I. Bermudez. Center for Studies of Sensory Impairment, Aging and Metabolism (CeSSIAM), Guatemala, Department of Public Health and Community Medicine and Tufts University School of Medicine. C78 II 639.2 Nutritional Status and Stunting Among Pre-School Children in Bhutan: FIndings of the 2015 National Nutrition Survey. Y. Kang, R.K. Campbell, K.P. West. Johns Hopkins School of Public Health. C79 I 639.3 The Impact of Nutritional Interventions on Linear Growth After 2 y of Life: A Systematic Review and Meta-Analysis of Controlled Trials. J.L. Roberts, A.D. Stein. Emory University. C80 II 639.4 Infant Nutritional Status and Markers of Environmental Enteric Dysfunction Are Associated with MidChildhood Anthropometry and Blood Pressure in Tanzania. L.M. Locks, R.S. Mwiru, E. Mtisi, K.P. Manji, C.M. McDonald, E. Liu, R. Kupka, R. Kisenge, S. Aboud, K. Gosselin, M.W. Gillman, A.T. Gewirtz, W.W. Fawzi, C.P. Duggan. Harvard TH Chan School of Public Health, Management and Development for Health, Tanzania, African Academy for Public Health, Tanzania, Muhimbili University of Health and Allied Sciences, Tanzania, Boston Children’s Hospital, United Nations Children’s Fund (UNICEF), Harvard Medical School and Georgia State University.
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NUTRITION SUNDAY C81 I 639.5 Consumption of Fortified Infant Foods Reduces Dietary Diversity But Has a Positive Effect on Subsequent Growth in Indonesian Infants. A. Diana, S.R. Mallard, J. Hazard, D.M. Purnamasari, I. Nurulazmi, P.D. Herliani, G.I. Nugraha, R.S. Gibson, L. Houghton. Universitas Padjadjaran, West Java, Indonesia and University of Otago, New Zealand. C82 II 639.6 Implications of Growth Model Selection on the Associations of Fetal and Infant Growth with Later Childhood Outcomes. A. Krishna, M. Leung, S. Yang, D. Bassani, D. Roth. The Hospital for Sick Children, Canada and McGill University, Canada. C83 I 639.7 Trunk-To-Leg Ratio in Regions of Extreme Stunting Prevalence in the Western Highlands of Guatemala: A Comparative Perspective and Interpretation. K. Shiu, J. Beintema, W.M. Liem, R. García-Meza, C. Doak, M. Orozco, N.W. Solomons. CeSSIAM, Guatemala. C84 II 639.8 Maternal Perceptions of Children’s Linear Growth in Bangladesh: Perspectives from Urban and Rural Caregivers of Diverse Parenting Experience. S.B. Ickes, M. Hossain, L. Rice, N. Naila, B. Nahar, D. Denno, T. Ahmed, J. Walson. University of Washington, International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Bangladesh. C85 I 639.9 A Novel Distribution Method to Provide Micronutrients at a Community Level Improves Linear Growth in Young Guatemalan Children. L.M. Villanueva, A.M. Palacios. The Mathile Institute. C86 II 639.10 Low Birth Weight Is More Common in Food Insecure Pregnant Malawian Women with Moderate Malnutrition. S. Quon, P. Papathakis, A. Schaffner, E. Finfer, L. Bell, B. Peace, M. Varni, E. Gates, C. Tolleshaug, M. Manary. California Polytechnic State University and Washington University School of Medicine. C87 I 639.11 Provision of Supplementary Food to Pregnant Malawian Women with Moderate Acute Malnutrition Improves Gestational Weight Gain and Reduces Low Birth Weight. P. Papathakis, A. Schaffner, P. Garcia, R. Eckert, J. Fry, S. Malek, I. Trehan, C. Thakwalakwa, K. Maleta, M. Manary. California Polytechnic State University, Washington University School of Medicine and University of Malawi, Malawi. C88 II 639.12 Metrics of Early Childhood Growth in Recent Human Growth Research: A Scoping Review. M. Leung, N. Perumal, E. Mesfin, A. Krishna, S. Yang, W. Johnson, D. Bassani, D. Roth. The Hospital for Sick Children, Canada, McGill University, Canada and Loughborough University, United Kingdom. C89 I 639.13 Association of Novel Complementary Feeding Indicators with Length-For-Age Z-Scores in Rural Malawi. E.C. Faerber, J. Ko, J. Weiss, A. Webb Girard. Emory University and Concern Worldwide, Malawi. C90 II 639.14 Maternal Factors Contribute to Low Cranial Size Among Mam-Mayan Infants in Guatemala. H.M. Wren, N.W. Solomons, M.E. Scott, K.G. Koski. McGill University, Canada, CeSSIAM, Guatemala and Center for Host-Parasite Interactions, Canada. C91 I 639.15 Infant and Young Child Feeding (IYCF) Indicators in Madagascar: Analysis of the Demographic and Health Survey. H. Rakotomanana, G. Gates, D. Hildebrand, B.J. Stoecker. Oklahoma State University.
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C92 II 639.16 Multiple Low-Level Metal Exposure and Indicators of Weight and Height in Uruguayan Urban School Children. C.M. Donangelo, E.I. Queirolo, N. Mañay, F. Peregalli, K. Kordas. Universidad de la Republica del Uruguay, Uruguay, Universidad Católica del Uruguay, Uruguay, Catholic University of Uruguay, Uruguay and University at Buffalo. C93 I 639.17 A Multi-Level Risk Factor Assessment for Stunting: Evidence from a National Sample in Nepal. J. Dorsey, S. Manohar, S. Neupane, B. Shrestha, A. ThorneLyman, P. Webb, R.D. Klemm, K.P. West Jr. Johns Hopkins Bloomberg School of Public Health, Nutrition Innovation Lab— Nepal, Nepal, Harvard TC Chan School of Public Health, Tufts University and Helen Keller International. C94 II 639.18 Early Childhood Linear Growth Faltering in Low- And Middle-Income Countries Is a Whole-Population Condition: Implications for Identifying the Causes of Stunting. D.E. Roth, A. Krishna, M. Leung, J. Shi, D. Bassani, I.C. da Silva, A. Barros. Hospital for Sick Children, Canada, Harvard T.H. Chan School of Public Health and Universidade Federal de Pelotas, Brazil. C95 I 639.19 Seasonal Differences in Birth Weights and Lengths Depend on Exposure During Pregnancy in Rural India. E.M. Madan, J.D. Haas, P. Menon, V. Kumar, A. Kumar, S. Singh, S. Dixit. Cornell University, International Food Policy Research Institute, India and Community Empowerment Lab, India. C96 II 639.20 Nutritional Resilience Following the 2015 Earthquake in Nepal. A.L. Thorne-Lyman, S. Manohar, B. Shrestha, S. Neupane, B. Nonyane, S. Shrestha, P. Webb, R.D W. Klemm, K.P. West Jr. Johns Hopkins Bloomberg School of Public Health, Harvard T.H. Chan School of Public Health, PoSHAN Study Team, Nepal, Tufts University Friedman School of Nutrition Science and Policy and Helen Keller International. C97 I 639.21 Secular Trends in Adult and Adolescent Maternal Nutritional Status and Birth Size from 2008–2012 in Rural Bangladesh. M. Na, A.A. Shamim, A.L. Labrique, H. Ali, L.S-F. Wu, S. Shaikh, R.D. Klemm, P. Christine, K.P. West. University of California Davis, FHI 360, Bangladesh, Johns Hopkins Bloomberg School of Public Health, JiVitA Project of Johns Hopkins University, Bangladesh, Helen Keller International and Bill & Melinda Gates Foundation. C98 II 639.22 Women’s Empowerment, Household Dietary Intake, and Individual Dietary Intakes in Urban Bangladesh: Repeated Cross-Sectional Study. S.S. Sinharoy, J. Waid, M. Ali, K.M. Yount, S.H. Thilsted, A. Webb-Girard. Emory University, Helen Keller International, Bangladesh and WorldFish, Cambodia. C99 I 639.23 Creating Healthy Food Interventions in Food Pantries: First and Separately Seen Is Selected. B. Wansink, H. Bhana. Cornell University and Columbia University. C100 II 639.24 Genome-Nutrition Divergence: Evolving Understandings of the Malnutrition Spectrum. J. Eaton, L. Iannotti. Washington University in St. Louis. C101 I 639.25 Quantification and Validation of a SemiStructured 24-Hour Diet Recall for Infants and Young Children in Rural Bangladesh. Z.T. Chowdhury, K. Hurley, R.K. Campbell, S. Shaikh, A. Shamim, S. Mehra, P. Christian. Johns Hopkins Bloomberg School of Public Health, JiVitA Project, Bangladesh, FHI360, Bangladesh and Bill & Melinda Gates Foundation.
SUNDAY NUTRITION C102 II 639.26 A Cross-Sectional Study in Rural Areas of Myanmar: The Impacts of Dietary Behaviors and Nutrition Intervention on 6- to 72-Month-Old Children. A. Zhao, H. Gao, N. Win, Y. Zhang. Peking University, People’s Republic of China, and Health Poverty Action Eastern Asia Programme Office, Myanmar. C103 I 639.27 Micro-Farming of Palm Weevil Larvae (Akokono) for Economic Empowerment and Nutritional Impact. M. Parker, S. Zobrist, C. Tawiah, G. Manu, K. Mansen, S. Soor, A. Laar, K. Kreis. PATH, Kintampo Health Research Centre, Ghana, Seattle Children’s Hospital, Aspire Food Group and University of Ghana, Ghana. C104 II 639.28 Dietary Protein Inadequacy Among Women of Reproductive Age from Five Low-Income Countries. J.E. Arsenault, K.H. Brown. University of California, Davis and Bill & Melinda Gates Foundation. C105 I 639.29 Assessing the Impact of Livestock Husbandry on Anemia in Women and Children: A Systematic Review. N.J. Lambrecht, A.D. Jones. University of Michigan. C106 II 639.30 Food Group Intake Differs Among Adult Food Secure, Low Food Secure and Very Low Food Secure Rural, Midwestern Emergency Food Pantry Users. B.N. Wright, L.A. McCormack, S. Stluka, D. Contreras, L. FranzenCastle, B. Henne, D. Mehrle, D. Remley, H.A. Eicher-Miller. Purdue University, South Dakota State University, Michigan State University, University of Nebraska-Lincoln, University of Missouri and Ohio State University. C107 I 639.31 The Association Between Animal Source Foods and Stunting in Children Aged 6 Months to 5 Years: A Systematic Review. M.J. Shapiro, S. Downs, D. Quelhas, K. Kreis, K. Kraemer, J. Fanzo. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, PATH and Sight and Life, Switzerland. C108 II 639.32 Cooking Time and Iron Bioavailability: The USDA-ARS Approach to Bean Fe Biofortification. R. Glahn, K. Cichy, E. Tako, J. Wiesinger. USDA-ARS. C109 I 639.33 A Grandmother-Inclusive Approach to Community Nutrition Positively Impacted Maternal Nutrition and Health Seeking Practices in Southern Sierra Leone. A.W. Girard, R. Wee, J. Simba, C. Gruenewald, J. Aubel, C. MacDonald, A.S. Bangura, B. Aidam. Emory University, World Vision, Sierra Leone, Sierra Leone, World Vision Germany, Germany, The Grandmother Project—Change Through Culture, Italy, World Vision Canada and Nutrition Centre of Expertise, Canada. C110 II 639.34 A Grandmother-Inclusive Approach to Community Nutrition Education Improves Infant and Young Child Feeding Outcomes in Southern Sierra Leone. R. Wee, J. Simba, B. Aidam, C. Gruenewald, J. Aubel, C. MacDonald, A.S. Bangura, A. Webb Girard. Rollins School of Public Health, Emory University, World Vision, Sierra Leone, Sierra Leone, World Vision Canada, Nutrition Centre of Expertise, Canada, World Vision Germany, Germany and The Grandmother Project—Change Through Culture, Italy. C111 I 639.35 Food Insecurity, Food Coping Strategies, and Child Health Among Ghanaians and Long Term Liberian Refugees Living in Ghana. A. Hromi-Fiedler, A. Lartey, D. Gallego-Perez, A. Sandow, R. Perez-Escamilla. Yale University, University of Ghana, Ghana, Boston University and Buduburam Nutrition Program, Ghana.
C112 II 639.36 Nutrient Analysis of Farmed Palm Weevil Larvae for the Advancement of Edible Insects in Ghana. M. Parker, S. Zobrist, K. Mansen, S. Soor, A. Laar, C. Asiedu, H. Lutterodt. PATH, Seattle Children’s Hospital, Aspire Food Group, University of Ghana, Ghana and Kwame Nkrumah University of Science and Technology, Ghana. C113 I 639.37 Ethnicity and Socioeconomic Factors Are Associated with Poor Nutritional Status in Female Tea Plantation Workers from Rural India. S. Venkatramanan, G.S. Marquis, J.D. Haas. McGill University, Canada and Cornell University. C114 II 639.38 Infant and Young Child Feeding (IYCF) Practices and Nutritional Status Under 2 Years of Age in Bhutan. R.K. Campbell, Y. Kang, K.P. West; Jr. Johns Hopkins Bloomberg School of Public Health. C115 I 639.39 Inadequate Zinc and Calcium But Adequate Iron Intakes in Lactating Women from Southern Ethiopia. M. Girma, H. Seid, B. Tilahun, B.J. Stoecker. Oklahoma State University and Hawassa University, Ethiopia. C116 II 639.40 The Manteca Yellow Bean: A Genetic Resource of Fast Cooking and High Iron Bioavailability Phenotypes for the Next Generation of Andean Dry Beans (Phaseolus vulgaris L.) J. Wiesinger, K. Cichy, E. Tako, J. Hart, R. Glahn. USDA-ARS. C117 I 639.41 Cross Sectional Survey of Pregnant Adolescent Malnutrition in Rural Malawi. C. Patella, C. Thakwalakwa, B.J. Stoecker. Oklahoma State University and University of Malawi, Malawi. C118 II 639.42 Exploring Aflatoxin Prevention and Control Practices in Banke, Nepal. J.Y. Andrews Trevino, S. Ghosh, B. Rogers, G. Shively, D. Davis, K.P. Baral, P. Webb. Tufts University, Purdue University, Helen Keller International, Nepal and Patan Academy of Health Sciences, Nepal. C119 I 639.43 El Niño Southern Oscillation Affects Girls’ Nutrient Intakes and Adequacies in the Peruvian Amazon. R. Ambikapathi, M. Kosek, P. Yori, M. Paredes Olortegui, B. Zaitchik, G.O. Lee, A. Bauck, L. Caulfield. Johns Hopkins Bloomberg School of Public Health, Biomedical Investigations Unit AB PRISMA, Iquitos Peru., Peru, Johns Hopkins University and University of Michigan. C50 I 957.21 United States Department of Agriculture (USDA) MyPlate-Based Nutrition Education Program Increases Adolescent Female Athlete Intention to Consume More Fruits and Vegetables. K. Sarigiannis, M. Hudson, V. Uhley. Oakland University William Beaumont School of Medicine and Avondale School District. C121 I 639.45 Socio-Demographic, Clinical and Behavioral Characteristics of Brazilian Dyslipidemic Adults Enrolled in a Lifestyle Modification Program. H.T. Kano, G.N. Vilches, L.P. Barros, O. Teixeira, R.M. Manda, R.C. Burini. UNESP Medical School, Brazil. C122 II 639.46 The Non-Caloric Sweeteners Aspartame, Sucralose and Stevia sp. Induce Specific but Differential Responses to Compartmentalized Adipose Tissue Accumulation. F.B. Pliego-Rivero, B.C. Sosa-García, G.B. Otero, R.B. Oros-Pantoja. UAEMEX-MEDICINA, Mexico.
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NUTRITION SUNDAY C123 I 639.47 Effectiveness of a 10-wk Lifestyle Modification Program in Reducing Hypertension in Brazilian Free-Living Adults. R.C. Burini, H.T. Kano, M.S. Nakagaki, T.C. Figueira, F.H. Burini. UNESP Medical School, Brazil and UEL/UEM Physical Exercise Graduate Program, Brazil. C124 II 639.48 Utilizing a Processing-Based Diet Index to Measure Change in BMI in a Population Undergoing a Nutrition Transition. E.L. Cooper. University of Michigan. C125 I 639.49 Economic Development and Associations with Growth of Preschool Children in the Middle East and North African Region. R.E. Jones, S. Cunningham. Emory Univeristy and Emory University. C126 II 639.50 Preconceptional Lipid-Based Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids in Guatemalan Women Who Are Overweight or Obese at 12 Weeks Gestation: A Pilot Study. S. Borengasser, M. Kerns, A. Palacios, P. Baker; II, J. Kemp, S. Morrison, J. Westcott, J. Friedman, A. Lucia Garces, L. Figueroa, M. Hambidge, N. Krebs. University of Colorado— Anschutz Medical Campus, University of Colorado—Denver, Medical School for International Health, Ben Gurion University of the Negev, Israel and Institute of Nutrition of Central America and Panama, Guatemala. C127 I 639.51 Changing Food Environments and Health Outcomes: Quantifying the Nutrition Transition in Global Nutrition Research. H.V. Becker, J.C. Eaton, L.L. Iannotti. Washington University in St. Louis. C128 II 639.52 Predicting and Modeling Follow-Up Clinic Visits (Persistence) After Bariatric Surgery. T. Brazell, J. Paynter, D. Thomas, K. Watts, D. Cottam. United States Military Academy and Bariatric Medicine Institute. C129 I 639.53 Dietary Trends in Energy, Carbohydrate, Protein, Fat, Sodium and Potassium Intake by Urbanicity Index in Chinese Adolescents from 1991 to 2011. A.L. Yu, N. LopezOlmedo, B. Popkin. University of North Carolina at Chapel Hill.
640. COMMUNITY AND PUBLIC HEALTH NUTRITION INTERVENTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C130 I 640.1 Assessing Nutrition Knowledge Using Healthy Plate Photo Method Among Youth Participating in WeCook. W. Chai, A. Walther, T. Dunker, L. Franzen-Castle, M. Krehbiel. University of Nebraska-Lincoln. C131 II 640.2 How Health-Related Signs Unexpectedly Promote Healthy Choices: Long-Term Conclusion for Nordic Cafeteria. B. Wansink, K.I. Karevold, S. Kallbekken, H. Tran. Cornell University, GreeNudge, Norway, University of Oslo, Norway and CICERO, Norway.
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C132 I 640.3 Supermarket Interventions That Encourage Sustainable Healthy Habits: Long Term Learning of Fresh Fish Sales in Grocery Stores. B. Wansink, K.I. Karevold, H. Tran. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C133 II 640.4 Feasibility of a Pilot Randomized Controlled Trial to Assess Health Impacts of Community Gardening. A.W. Beavers, K. Burr, K. Li, R. Pimentel, D. Glueck, J. Hebert, A. Masunaga Goto, L. Fahnestock, R. Knight, K. Alaimo, J. Litt. Michigan State University, University of Colorado School of Medicine, Colorado State University, University of Colorado School of Public Health, University of South Carolina, Brown University, Denver Urban Gardens, University of California San Diego and University of Colorado Boulder. C134 I 640.5 Vegetable Velocity: More Time in Aisle Means More Produce in Carts. B. Wansink, A. Mukund. Cornell University and University of Washington. C135 II 640.6 Conducting Behavioral Field Research in Food Pantries: Lessons and Tactics for Testing Nutrition Interventions. B. Wansink, H. Bhana. Cornell University and Columbia University. C136 I 640.7 First Foods Are Frequently Selected Most but in Smaller Amounts: Long-Term from Nordic Cafeteria. B. Wansink, K.I. Karevold, H. Tran. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C137 II 640.8 Impact of the National Crusade Against Hunger on Dietary Diversity in Mexican Women. M. MoralesRuán, B. Martínez Tapía, V. Mundo Rosas, T. Shamah-Levy, I. Mendez Gómez-Humarán. National Institute of Public Health, Mexico and Mathematics Research Center, Mexico. C138 I 640.9 Behaviour Change Communication Using Mobile Phones: Implications for Infant and Young Child Feeding Interventions. A. Mildon, D. Sellen. University of Toronto, Canada. C139 II 640.10 Iron Status of Reproductive Age Women in Northern Ghana Is Improved by Indigenous Hibiscus Sabdariffa Meal. C. Kubuga, S. Song, G. Kennedy, K. Lee, W. Song. Michigan State University, University for Development Studies, Ghana and Bioversity International, Italy. C140 I 640.11 Vitamin A Sugar Fortification in Zambia: Opportunities and Challenges. M. Greene, G. Kabaghe, M. Musonda, A.C. Palmer. Johns Hopkins Bloomberg School of Public Health and National Food and Nutrition Commission, Zambia. C141 II 640.12 Make-It-Yourself (MIY) Food Stations: Long-Term Healthy Lessons from Nordic Cafeterias. H.Q. Tran, B. Wansink, K.I. Karevold. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C142 I 640.13 Mobilizing Markets: Community Efforts to Decrease Food Insecurity in Meadville, Pennsylvania. K. Martin, T. Hinton, D. Anderson, E.J. Schafer, R. Smullin Dawson. Allegheny College. C143 II 640.14 Impact of Health Workers Infant Feeding Practices Training on the Prevalence of Functional Constipation Among Children at Six Years Old. A Cluster Randomized Field Trial. C.N. Sangalli, M.B. de Morais, M.R. Vitolo. Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil and Universidade Federal de São Paulo, Brazil.
SUNDAY NUTRITION C144 I 640.15 Food Selection by According to Food Processing: Fabulous or Flawed. J.A. Jones. St. Catherine U. Emerita. C145 II 640.16 Reinforcement as a Parenting Strategy Related to Children Obesogenic Behaviors Is Associated to Mothers’ but Not Fathers’ Education Level Among Health Workshop Participants in Mexico City. A.B. Perez-Lizaur, A.C. Fernandez-Gaxiola, M. Damacio, L. Moreno-Landa. Universidad Iberoamericana, Mexico. C146 I 640.17 A Reliable Instrument of Health Literacy in Hospitalized Patients: 3-Question Brief Health Literacy Screen (BHLS). D. Dikmen, B. Madalı, A. Özdemir, E. İnanEroğlu. Hacettepe University, Turkey. C147 II 640.18 Design and Baseline Characteristics of a Study Comparing Four Supplementary Foods in the Prevention of Stunting and Wasting Among Children 6–23 Months in Burkina Faso. I. Cliffer, B. Langlois, D. Suri, S. Walton, L. Ouedraogo, A. Zeba, H. Lanou, F. Garanet, P. Webb, B. Rogers. Tufts University, University of Wisconsin and Ministry of Scientific Research and Innovation, Burkina Faso. C148 I 640.19 Healthy Eating, Mindfulness, Exercise, and Lifestyle in Overweight and Obese Postmenopausal Breast Cancer Survivors (HEELS): A Pilot Study—Approach, Feasibility, and Acceptability. E.L. Sattler, A.M. Washington, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, M. Davis. University of Georgia. C149 II 640.20 Experiences of Beneficiary Caregivers in a Supplementary Feeding Program in Southern Malawi. B. Langlois, D. Suri, S. Walton, B. Rogers. Tufts University and University of Wisconsin-Madison. C150 I 640.21 The Impact of Program Structure on Outcomes of the Illinois Junior Chefs Program. R. Liu, J.J. Metcalfe, E. Emberton, B. Fiese, J.J. McCaffrey. University of Illinois at Urbana-Champaign. C151 II 640.22 State of Hypertension, Diabetes Mellitus and Anemia Among Residents of Selected Communities in Ghana. M.A. Tandoh, E. Johnson, A.K. Anderson. University of Georgia. C152 I 640.23 Camp NERF: Caregiver Outcomes from a Theory-Based Nutrition Education Recreation and Fitness Program Aimed at Preventing Unhealthy Weight Gain in Underserved Children During Summer Months. L.C. Hopkins, A. Webster, A. Sharn, C. Gunther. The Ohio State University. C153 II 640.24 Pilot Study on Influencing Healthy Food Acceptance in Young Children Through Play-Based Activities and Food Exposures. A.G. Taetzsch, E. Hennessy, S. Taylor, A. Maaliki, D. Rao, L. Ng, A. Krauss, A. Wolfgang, A. Fleming, S. Das, C.D. Economos, S.B. Roberts. HNRCA/ Tufts University, Friedman School of Nutrition Science and Policy and Tufts University. C154 I 640.25 Determinants of Dietary Supplement Use and Compliance by US Adults. A. Bogale, D. MacKay, S.H. Mitmesser. The Natures Bounty Co. and The Council for Responsible Nutrition. C155 II 640.26 Population Health Interventions to Curb Intake of Sugars: Gaps in the Evidence. S. Kirkpatrick, M. Maynard, A. Raffoul, J. Stapleton. University of Waterloo, Canada.
C156 I 640.27 Perception and Barriers to CalFresh Utilization Among Asian Pacific Islander Communities in Southern California. N.P. Louie, L.P. Kim, S. Chan. Pepperdine University and Asian Pacific Islander Obesity Prevention Alliance (APIOPA). C157 II 640.28 Development and Testing of a Pilot Integrated Mental Health and Nutrition Education Program for Low-Income Families in Southern California. R.P. Spitz, L.P. Kim, J.H. Gavazza. Pepperdine University, Pepperdine University and Graduate School of Psychology and Education (GSEP). C158 I 640.29 Nutrition Education in a University Wellness Program. L.R. Menge, S.H. Crixell, L.K. Lloyd, J. Bezner. Texas State University. C159 II 640.30 Nutrition Knowledge and Dietary Practices Among Pre-Adolescent Children (6–11 Years Old) in Rural South Africa. B.A Z. Abu, W. Oldewage-Theron, E. Abdulkadir. Texas Tech University, Centre Vaal University of Technology, South Africa and Vaal University of Technology (VUT), South Africa. C160 I 640.31 Gender Differences in Dietary Attitudes and Behaviors of Participants in the Illinois Junior Chefs Program. E. Emberton, J.J. Metcalfe, R. Liu, B. Fiese, J. McCaffrey. University of Illinois at Urbana-Champaign. C161 II 640.32 Labeling Policy for Genetically Modified and Organic Food: Impact on Consumer Choice. S.M. Wunderlich, K.A. Gatto, M. Mangano. Montclair State University. C162 I 640.33 Half-Carts: Partitioned or Divided Grocery Carts Lead to Greater Fruit and Vegetable Purchases in Supermarkets. B. Wansink, D. Solman, K. Herbst. Cornell University, University of Toronto, Canada and Wake Forest. C163 II 640.34 Impact of the National Crusade Against Hunger (CNCH) on Anemia and Dietary Diversity Among Mexican Children. V. Mundo Rosas, T. Shamah Levy, B. Martínez Tapia, I. Méndez Gómez-Humarán. National Institute of Publich Health, Mexico, Mexico. C164 I 640.35 Overweight and Obesity in Mexican Children and Adolescents: Data from National Nutrition and Health Surveys in 2016. L. Cuevas-Nasu, T. Shamah Levy, M.A. Avila Arcos, I. Mendez Gomez, J. Rivera Dommarco. National Institute of Public Health, Mexico and Center for Research in Mathematics, Mexico. C165 II 640.36 Igniting Youth to Create Healthier Communities: Year 4 Policy Changes. K. Kattelmann, B. Chen, M. Erickson, S. Zies, M. Jess, Y. Li, N. Muturi, E. Lindshield, D. Remley, T. Kidd. South Dakota State University, Ohio State University Extension and Kansas State University. C166 I 640.37 Effectiveness of the Children’s Healthy Living (CHL) Multilevel Multicomponent Community Intervention Program in 5 US Affiliated Pacific Jurisdictions. R. Novotny, L.R. Wilkens, C.R. Nigg, K. Braun, J. Butel, A. Areta, P. Coleman, T. Belyeu-Camacho, J. Greenberg, A. Bersamin, R. Leon Guerrero, L.R. Barber, M.K. Fialkowski, E. De la Cruz-Talbert. University of Hawaii, American Samoa Community College, American Samoa, Northern Marianas College, Northern Mariana Islands, University of Alaska and University of Guam, Guam.
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NUTRITION SUNDAY C167 II 640.38 Social Media Marketing on Popular Sugar-Sweetened Beverages Facebook and Twitter Pages in Mexico. P. Hernández Chávez, A. Velasco Bernal, P. Aguilar Menéndez, B. Bolado Velázquez. Instituto Nacional de Salud Pública, Mexico. C168 I 640.39 Families with Preschool Children Meet Behavior Change Goals Using the Homestyles Express Breakfast the Right Start Guide Paired with Telephone Counseling. C. Delaney, J. McKinley, J. Martin-Biggers, C. Byrd-Bredbenner. Rutgers University. C169 II 640.40 Wellness Characteristics of College Freshmen at West Virginia University. A.M. Morris, M.L. Barr, O.A. Famodu, S.E. Colby, W. Zhou, R.L. Hagedorn, R.L. Clark, K. Riggsbee, M.D. Olfert. West Virginia University and University of Tennessee. C170 I 640.41 High-Energy Dense Food and SugarSweetened Beverages Are Most Likely Placed and Available at Special Displays in Stores of Mexico City. P. Aguilar, A. Velasco Bernal, B. Bolado Velázquez, P. Hernández Chávez. Instituto Nacional de Salud Pública, Mexico.
641. CHILDHOOD OBESITY/SCHOOLBASED EDUCATION Poster (Sponsored by: Community Nutrition and Public Health RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C171 I 641.1 The Victoria Trial: A School-Based Health Education Program to Reduce the Risk of Obesity Among a High-Risk Population. M.A. Mejia, A. Coria-Navia, G. Uriegas-Mejia, S.C. Brown-Fraser, S.E. Uriegas, M. Martinez, A. Sanchez, M.E. Acosta, A.E. Ramirez, R.E. Reyes, Y.C. Hernandez, D.Y. Camacho, G. Morrow, G. Krivak. Andrews University, Opti Health, PLLC, Secretaria de Salud de Tamaulipas, Mexico, Weimar Institute, Universidad de Montemorelos, Mexico and Secretaria de Educacion Publica, Mexico. C172 II 641.2 A Qualitative Examination of Barriers and Facilitators to Physical Activity for Rural Adolescents. B. Chen, K. Kattelmann, A. Daniels, S. Zies, E. Lindshield, T. Kidd. South Dakota State Univerisity, South Dakota State University, Ohio State University and Kansas State University. C173 I 641.3 The Association Between Children’s Weight Status Awareness and Nutritional, Physical Activity Knowledge, Attitude and Behavior in Rural Taiwan. H. Yang, Y. Lin, H. Wu, H. Chen. Mackay Medical College, Taiwan and National Yang-Ming University, Taiwan. C174 II 641.4 Cooking with Kids: Eating the Same but Behaving Better. H. Kessler, B. Wansink, C.M. Velez Argumedo. Cornell University and EGADE Business School, Mexico.
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C175 I 641.5 The Hidden Persuaders: Childhood Eating Patterns That Correlate with Weight Gain and Obesity. H. Kessler, C.O. Werle, B. Wansink. Cornell University and Grenoble Ecole de Management, France. C176 II 641.6 Branding Techniques and Their Impact on Healthy Selection in School Cafeterias. G. Gabrielyan, B. Wansink, D.R. Just, A.S. Hanks, A. Brumberg. Cornell University and Ohio State University. C177 I 641.7 A Systematic Review of Randomized Clinical Trials Examining Effects of Breakfast Composition on Weight Outcomes Among Children and Adolescents. Z. Fu, H. Almahmassani, M. Chung, C. Cook. Tufts University School of Medicine, Tufts University Friedman School of Nutrition Science and Policy and Biofortis. C178 II 641.8 Four-Year Follow Up of an Integral Health Program to Control Parameters Associated with Childhood Obesity. N.G. Valenzuela-Rubio, F.H. CastroSanchez, M.J. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico. C179 I 641.9 The Perception of School Milk Program and Consumption of Calcium Source of Middle School Students in Gyeonggi, Korea. H. Lee, G. Park. Daejin University, Republic of Korea. C180 II 641.10 Development of a Health Education Curriculum to Reduce the Risk of Obesity Among Hispanic School-Age Children. M.A. Mejia, A. Coria-Navia, G. UriegasMejia, S.C. Brown-Fraser, S.E. Uriegas, M. Martinez, A. Sanchez, M.E. Acosta, A.E. Ramirez, R.E. Reyes, Y.C. Hernandez, D.Y. Camacho, G. Morrow, G. Krivak. Andrews University, Opti Health, PLLC, Secretaria de Salud de Tamaulipas, Mexico, Weimar Institute, Universidad de Montemorelos, Mexico and Secretaria de Educacion Publica, Mexico. C181 I 641.11 A Comparative Study on Dietary Habit and Nutrition Knowledge of Middle School Students in Seoul Area, Korea. Y. Kim, S. Cho. Inha University, Republic of Korea. C182 II 641.12 A Comparative Study on Dietary Habit and Weight Control of Middle School Students in Gyonggi-Do, Korea. Y. Kim, S. Yang. Inha University, Republic of Korea. C183 I 641.13 The Locus of Control and Likelihood of Success: Evidence from School Lunchrooms. G. Gabrielyan, K. Greene, D.R. Just, B. Wansink. Cornell University. C184 II 641.14 Implementation of an Adapted GardenEnhanced Nutrition Curriculum for Use Among Fourth-Grade Students in an Urban City in Mexico: A Feasibility Study. J. Rodriguez-Jordan, L.E. Vera-Becerra, N.B. Smith, S. Zidenberg-Cherr. University of California, Davis, University of Guanajuato and Campus León, Mexico. C185 I 641.15 Development and Dissemination of a Learner-Centered Nutrition Curriculum for School Nutrition Services Staff. A.M. Jones, J. Bergman, M. Briggs, K. Brian, S. Zidenberg-Cherr. University of California, Davis, University of California Cooperative Extension and University of California Agriculture and Natural Resources.
SUNDAY NUTRITION
642. CHILDHOOD OBESITY: CAUSES, CORRELATIONS, AND TREATMENT
(Sponsored by: Obesity RIS)
C197 II 642.12 Presence of a Risk FTO Polymorphism in Young Adults from Northwestern Mexico and Its Association with Biomarkers of Overweight and Obesity. H. AstiazaranGarcia, A. Rendon-Del Cid, E. Urias-Cazarez, B.I. PachecoMoreno, G.G. Morales-Figueroa, I. Anduro-Corona. CIAD, Mexico.
Sun. 9:00 am—McCormick Place Convention Center, Hall F
643. OBESITY I
Poster
Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C186 I 642.1 Associations of Breastfeeding, Diet Quality and Physical Activity with BMI in Adolescents. E. Shields, L. Shanahan, L. Wideman, S. Calkins, S. Keane, C. Lovelady. University of NC at Greensboro and University of Zurich, Switzerland. C187 II 642.2 Association Between Weight-Related Health Behaviors and Weight Perception in Adolescents with Overweight or Obesity. K.A. Borton, S.L. Hahn, K.R. Sonneville. University of Michigan. C188 I 642.3 Education Level Influences WeightRelated Cognitions and Behaviors of Parents with Preschoolers. K. Eck, V. Quick, J. Martin-Biggers, C. Delaney, C. ByrdBredbenner. Rutgers University. C189 II 642.4 Eating Frequency and the Role of Snacking on Weight of Minority Preschool Children. A. Charvet, F.G. Huffman. Florida International University. C190 I 642.5 Physical Activity, Sedentary Behavior, and Obesity in U.S. Children Ages 6–12. P. Haddadian, M. Huwaikem, J.A. Vaccaro, G.G. Zarini, F.G. Huffman. Florida International University. C191 II 642.6 Maternal Perception of Child Overweight Status and Its Impact on Parenting Practices, Their Children’s Health Behaviors and Weight Change in China. J. Min, V.H. Wang, H. Xue, J. Mi, Y. Wang. Ball State University, Wagner School of Public Service, New York University, Capital Institute of Pediatrics, People’s Republic of China. C192 I 642.7 What Words and Actions Predict Adult and Daughters Weight Satisfaction? H.Q. Tran, B. Wansink, D.C. Christian. Cornell University and BI Norwegian Business School, Norway. C193 II 642.8 Away from Home Eating Is Associated with Increases in Dietary Energy Density in US Children: Findings from the National Youth Fitness Survey. A. Tacinelli, J.A. Vernarelli. Fairfield University. C194 I 642.9 Effects of Dried Apple Consumption on Body Composition, Inflammatory Markers and Lipid Profile in Overweight and Obese Children. P. Nagarajan, A. Tunstall, L. Almaiman, C. Cabalbag, D. Metti, M. Hong, M. Kern, S. Hooshmand. San Diego State University. C195 II 642.10 Saturated Free Fatty Acids Induce Trophoblast Lipoapoptosis. S. Natarajan, T. Bruett, E. Muthukrishnan, M. Islam, J.L. Mott. University of NebraskaLincoln and University of Nebraska Medical Center. C196 I 642.11 Effects of a 12-Week Lifestyle Intervention in a Mixed Sample of Rural Youth with Obesity. K. Johnson, D. Nicoara, R. Sorrells, J.P. Yi-Frazier, K. Briggs Early. Pacific Northwest University of Health Sciences and Seattle Children’s Research Institute.
Poster (Sponsored by: Obesity RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C198 I 643.1 Does Monitoring Your Hunger via Blood Glucose Help You Eat to Appetite and Lose Weight? M.R. Jospe, R.W. Taylor, J. Athens, M. Roy, R.C. Brown. University of Otago, New Zealand. C199 II 643.2 The 25-Day Tipping Point: Everyday Adherence Has Multiplicative–Not Additive–Benefits to Weight Loss. D.R. Just, R.W. Patterson, B. Wansink. Cornell University and United States Military Academy. C200 I 643.3 A Double Blind, Randomized, PlaceboControlled Study of Salacia Chinensis, with Alpha-Glucosidase Inhibitor Properties, on Post-Prandial Glycemia. L. Hao, K. Fieselmann, S. Schneider, Y. Schlussel, S. Shapses. Rutgers University and Rutgers-Robert Wood Johnson University Hospital. C201 II 643.4 A Comparison of Protein and Fiber Content in 52 Chain Restaurant Menus. Y. Wang, R. Lau, D.S. Brown, J. Cino, R. Jung, M. Mizuki, M. Wang, S. You, M.T. Nakamura. University of Illinois at Urbana-Champaign. C202 I 643.5 The Critical Role of Individual Trait Differences in Transcranial Direct Current Stimulation Outcomes: Effects in a Sample with Non Binge-Eating Obesity. M. Ray, M.D. Sylvester, L. Osborn, J. Helms, B. Turan, M. Boggiano. University of Alabama at Birmingham. C203 II 643.6 Does Higher Protein Quality Breakfast Reduce Energy Intake When Following a Weight Loss Diet Plan. D. Bailey, A. Childress, A. Shastri, G. Anderson, V. Hegde, J.A. Dawson, N.V. Dhurandhar. Texas Tech University. C204 I 643.7 Nutritional Status 6 Weeks After Gastric Bypass Bariatric Surgery: Comparison of Two Nutritional Support Plans. R. DiSilvestro, P. Choban, F. Aguila. Medinutra LLC and Mt Carmel Hospital. C205 II 643.8 Birth Weight, Early Life Weight Gain and Age at Menarche: A Systematic Review of Longitudinal Studies. F. Juul, V. Chang, P. Brar, N. Parekh. NYU College of Global Public Health, NYU School of Medicine, Steinhardt School of Culture, Education, and Human Development and New York University. C206 I 643.9 Visceral Adiposity Index in Prediabetes and Diabetes: The Polish Norwegian Study (PONS). G. Vaidean, M. Manczuk, S. Vansal. Fairleigh Dickinson University, Icahn School of Medicine at Mount Sinai and Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Poland.
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NUTRITION SUNDAY C207 II 643.10 Protein Carbonylation Is Related to Liver Damage in an Experimental Model of Obesity. F. Moreto, A. Ferron, F. Francisqueti, F. Hasimoto, J. Garcia, L. Ghiraldeli, E. Ribeiro, C. Correa, A. Ferreira. Sao Paulo State University, Brazil. C208 I 643.11 Heart Inflammation Is Associated to Carbohydrate-Enriched Diet in an Experimental Model of Obesity. A.A. Ferreira, A.J. Ferron, F. Moreto, F.V. Francisqueti, K.A. Kitawara, A.T. Lo, A.C. Ferraz, J.L. Garcia, L. Ghiraldeli, C.R. Correa. Botucatu Medical School, Sao Paulo State University, Brazil, Brazil and Sao Paulo State University, Brazil. C209 II 643.12 Interrelationship Between Total and Undercarboxilated Osteocalcin Levels, and Body Mass Index in Women. L. Zago, C. González Infantino, S. Zeni, M. Río, A. Felipoff, A. Weisstaub, H. Dupraz, N. Presner. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Nutrición, Argentina, Universidad de Buenos Aires and Hospital de Clínicas, Argentina. C210 I 643.13 Obesity and Weight Loss Pre-Kidney Transplantation. E. Tantisattamo. Oakland University William Beaumont School of Medicine. C211 II 643.14 Machine Learning Approach to Identify Optimal Criteria for Successful Weight Loss Maintenance on the Basis of Cardiometabolic Risk Factors at Year 4 of the Look AHEAD Trial. S.E. Berger, G.S. Huggins, J.M. McCaffery, P.F. Jacques, A.H. Lichtenstein. Friedman School of Nutrition Science and Policy, Tufts University, Tufts Medical Center and Tufts University Sackler School of Graduate Biomedical Sciences, Miriam Hospital and Warren Alpert School of Medicine, Brown University, JM USDA Human Nutrition Research Center on Aging and Tufts University. C212 I 643.15 Umami Taste Perception Following Dietary Glutamate Supplementation. C.A. Noel, R. Dando. Cornell University. C213 II 643.16 Dietary Fatty Acid Composition Impacts Plasma Fatty Acid Ethanolamides and Body Composition in Golden Syrian Hamsters. J. Sihag, D.J. Jones. University of Manitoba, Canada. C214 I 643.17 Effects of A High-Fat Diet on Spontaneous Locomotor Activity and Blood Metabolic Biomarkers in Sprague Dawley Rats. W. Chia-Ying, Y. Yang, C. Chen, J. Chang, S. Tsai, C. Chen, C. Chen, J. Bernard, Y. Liao. National Taipei University of Nursing and Health Sciences, Taiwan, University of Taipei, Taiwan, Chang Gung University, Taiwan, California State University at Stanislaus. C215 II 643.18 The 2015 Dietary Guidelines for Americans: Adherence to Key Recommendations in Hispanic Females. B. Hannon, E. Villegas, A. Wiley, M. Teran-Garcia. University of Illinois at Urbana-Champaign. C216 I 643.19 Femur Cortical Bone Mineral Content Is Increased with High Protein Intake During Ad Libitum But Not Energy Restricted Conditions in Obese Female Zucker Rats. P. Marszewski, S.R. Hennigar, A.M. Kelley, B.J. Anderson, J.P. McClung, E. Gaffney-Stomberg. United States Army Research Institute of Environmental Medicine. C217 II 643.20 Anti-Obesity Effects of Solar Salt Prepared from Concentrated New Sea Water on 3T3-L1 Adipocytes. K. Park, E. Park, J. Ju, S. Choi. Cha University, Republic of Korea, Yonsei University, Republic of Korea, Docho Salt Co., Republic of Korea.
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C218 I 643.21 Red Sweet Cherry Ameliorates Inflammation in Obese Diabetic (db/db) Mice. G. Noratto, B.P. Chew, S.U. Mertens-Talcott. Texas A&M University. C219 II 643.22 Regulation of Gene Expression of Wnt Signaling Pathway by Dietary High Fat and Effects on Colon Epithelia of Male Mice. G. Xu, R. Emmons, D. HernándezSaavedra, A. Kriska, Y. Pan, H. Chen. University of Illinois at Urbana-Champaign. C220 I 643.23 Changes in Food Cravings During Dietary Carbohydrate Restriction. C. Heimowitz, M. Syed Abdul, Q. Hu, N. Le, K. Bingham, V. Cox, E.J. Parks. Atkins Nutritionals, Inc and University of Missouri. C221 II 643.24 Effects of Consuming a High Protein Diet with or Without Soy Protein on Transformative Weight Loss and Maintenance: A Non-Inferiority, Randomized Clinical Efficacy Trial. K.J. Speaker, J.C. Peters, H.K. Nelson, Z. Pan, H. Wyatt, M. Flock, R. Mukherjea, J.O. Hill. University of Colorado Anschutz Medical Campus and Dupont Nutrition and Health. C222 I 643.25 Dietary Diversity in Mexican Adolescents from a 2016 National Survey. E.B. GaonaPineda, S. Rodriguez-Ramirez, B. Martinez-Tapia, D.G. Valenzuela-Bravo, L.M. Gomez-Acosta, T. Shamah-Levy. National Institute of Public Health, Mexico. C223 II 643.26 Dietary Diversity in Mexican PReschool Children: Data from National Nutrition and Health Surveys in 2016. L.M. Gómez-Acosta, E.B. Gaona-Pineda, S. RodriguezRamirez, B. Martínez-Tapia, D.G. Valenzuela-Bravo, T. Shama-Levy. Instituto Nacional de Salud Pública, Mexico. C224 I 643.27 Effects of Dietary Vitamin D Deficiency and High Fat Feeding on Adiposity, Food Intake, and Cortical Serotonin in Mature Mice. Y. Wang, S.A. Shapses, N.T. Bello, J.W. Miller. Rutgers University. C225 II 643.28 Screen Time Is Associated with Lower Healthy Eating Index (HEI)-2010 Total Score in Low-Income Hispanic Pregnant Women in the Starting Early Study. L.T. Berube, K. Woolf, R. Gross, M.J. Messito. New York University, Albert Einstein College of Medicine and New York University School of Medicine. C226 I 643.29 I’m Staying in Tonight: Cooking at Home Predicts Lower Dietary Energy Density and Lower Risk for Obesity in a Nationally Representative Sample of US Adults. S. Sawicki, J.A. Vernarelli. Fairfield University. C227 II 643.30 Effects of a 12-Week Telenutrition Weight Loss Intervention on Diet Quality in Men. A. Kapostasy, M. Drazba, M. Shotwell, M.V. Marra. West Virginia University and Vanderbilt University. C228 I 643.31 Dietary Patterns of African American and Caucasian Females Seeking Bariatric Surgery. K. McLean, C. Moore, D. Miketinas, C. Champagne. Texas Woman’s University, Louisiana State University and Pennington Biomedical Research Center. C229 II 643.32 Evaluation of a Novel Bioimpedance Analysis Equation Development Approach. J. Zheng, B. Bourgeois, S.B. Heymsfield. Pennington Biomedical Research Center and Louisiana State University.
SUNDAY NUTRITION C230 I 643.33 Television Watching Is Positively Associated with Body Composition Among Adults with High Genetic Predisposition to Obesity: Population-Based Study in South China. H. Xue, J. Zhang, D. Li, J. Luo, G. Cheng. Sichuan University West China School of Public Health, People’s Republic of China. C231 II 643.34 Percent Body Fat Determination: Influence of Bone Mineral in Female Athletes. D.M. Foote, C.A. Horswill. University of Illinois at Chicago. C232 I 643.35 The Cross-Sectional Association Between Eating Frequency and Body Composition Among Adults in South China. Y.-y. Chen, H. Xue, J. Yin, G. Cheng. West China School of Public Health, ichuan University, People’s Republic of China. C233 II 643.36 Comparison of Body Fat Measurement Using Bioimpedance or Plicometry in Normal and Obese Subjects: An Internal Validation Study. F.H. Castro-Sanchez, N.G. Valenzuela-Rubio, M. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico. C234 I 643.37 Dietary Intake and Breastfeeding Practices Differ Between Women Who Gain Versus Lose Muscle Mass from 3 to 9 Months Postpartum. S.A. Elliott, L.C. Pereira, L.J. McCargar, C.C. Prado, R.C. Bell. University of Alberta, Canada. C235 II 643.38 Plasma Volume in Healthy Reproductive Age Women Using Indocyanine Green Dye. S. Aguree, A. Gernand. The Pennsylvania State University. C236 I 643.39 Associations Between Neck Circumferences and Measures of Health in Young Adults. O.A. Famodu, M.L. Barr, S.E. Colby, W. Zhou, C. Bryd-Bredbenner, A.E. Mathews, M.D. Olfert. West Virginia University, University of Tennessee, Rutgers University and University of Florida. C237 II 643.40 Intermuscular Adipose Tissue According to Obese Phenotype in Korean Obese Individuals. J. Yim, Y. Kim. Changwon National University, Republic of Korea, Jung Hopital, Republic of Korea.
644. NUTRIENT GENE INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C238 I 644.1 Increased Transcription of the SeryltRNA Synthetase (SARS) Gene in Response to Amino Acid Limitation Is Mediated by an Intronic C/EBP-ATF Response Element (CARE) That Functions as an Distal Enhancer. J. Shan, J. Sharkey, S. Tsang, M.S. Kilberg. University of Florida College of Medicine. C239 II 644.2 Nutrient Transporter Expression in Bovine Utero-Placental Tissue Is Altered by the Supply of Dietary Methionine During Late-Gestation. F. Batistel, A.S. Alharthi, C. Parys, B. Saremi, J. Loor. University of Illinois and Evonik Nutrition & Care GmbH, Germany. C240 I 644.3 Diet and MicroRNA Expression: A Systematic Review. S.A. McNaughton, J. Danaher, A.P. Russell. Deakin University, Australia.
C241 II 644.4 Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxyvitamin D3 Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells. J. Daleprane, T. Texeira, F. Bezerra. Rio de Janeiro State University, Brazil. C242 I 644.5 Carriers of Polymorphisms of Antioxidant Enzymes CAT-21 (A>T; rs7943316), SOD-1 -251 (rs2070424) and Sod-2 (rs4880) Present a Better Response on Cardiovascular Risk Indicators After a Dietary Intervention. C. Hernández, P. Hernández Chávez, A. Parra Carriedo, D. Juagardo Lopez, S. Ramirez Del Alto, A. Pérez Lizaur. Universidad Iberoamericana, Mexico. C243 II 644.6 LCT Gene Variant (-13910C>T) and the Plasma Proteome: A Mendelian Randomization Study. O. Alharbi, A. El-Sohemy. University of Toronto, Canada. C244 I 644.7 Effect of Histone Deacetylase Inhibitors on Vitamin D Dependent Gene Expression in Human Colorectal and Breast Cancers. S. Hossain. University of Massachusetts Amherst. C245 II 644.8 Characterization of Expression Levels of Genes Involved in Adipogenesis and Inflammation in Congenic Mice Carrying Obesity and Hyperlipidemia QTL on Chromosome 1 J.K. Parkman, J. Kim. Joan C. Edwards School of Medicine and Marshall University. C246 I 644.9 Supplementation with ω3 Polyunsaturated Fatty Acids Decreases Fasting Insulin and Hemoglobin A1c Levels in Healthy Mexican Adults: The Role of PPAR&γ2 P12a. A. Binia, L. Gosoniu, D. Martínez-Soria, F. Vadillo-Ortega, P. Valet, M. Kussmann, I. Silva Zolezzi, M. Tejero. Nestlé Research Center, Switzerland, Unidad de Vinculación de la Facultad de Medicina, Mexico, Institut des Maladies Metaboliques et Cardiovasculaires, France, The Liggins Institute, New Zealand and Instituto Nacional de Medicina Genómica (INMEGEN), Mexico. C247 II 644.10 Genetic Variation in CholineMetabolizing Enzymes Alters Choline Dynamics in Women Meeting Current Dietary Recommendations. A.B. Ganz, V.V. Cohen, C.C. Swersky, J.A. Stover, G.A. Vitiello, J. Lovesky, J. Chuang, K. Shields, V.G. Fomin, Y.S. Lopez, S. Mohan, A. Ganti, B. Carrier, O. Malysheva, M.A. Caudill. Cornell University. C248 I 644.11 Single Nucleotide Polymorphisms in FADS2, CETP and LPL and the Associations with Blood Lipids and Fatty Acids Differ in a Sex-Specific Manner. S.L. Klingel, K. Roke, D.M. Mutch. University of Guelph, Canada. C249 II 644.12 Associations Between Single Nucleotide Polymorphisms in Vitamin D Metabolic Pathway Genes and Serum 25(OH)D Concentrations in Brazilian Adults: The Pró-Saúde Study. F.F. Bezerra, A.P. da Fonseca, V.M. Zembrzuski, M.C. Junior, P.H. Cabello, E. Faerstein. Universidade do Estado do Rio de Janeiro, Brazil, Instituto Oswaldo Cruz—Fiocruz, Brazil and Universidade do Grande Rio, Brazil. C250 I 644.13 Prenatal Exposure to a Maternal LP Diet Decreases BDNF Expression in the Brains of the Neonatal Offspring. G. Marwarha, K. Claycombe, J. Lilek, O. Ghribi. University of North Dakota, U.S. Department of Agriculture, Agricultural Research Service and Grand Forks Human Nutrition Research Center. C251 II 644.14 Withdrawn.
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NUTRITION SUNDAY C252 I 644.15 Gene Expression and Epigenetic Regulations in Reshimax Anti-Aging Effect. Y. Ren, J. Lu, L. Gao, Y. Yao, J. Yang, Y. Zhang, D. Stevenson, M. Bartlett. Nu Skin (China) Daily-use & Health Products Co., Ltd., Center of Anti-aging Research, People’s Republic of China, and Nu Skin Enterprises. C253 II 644.16 Interaction Between the Ratio of Polyunsaturated Fat and Saturated Fat Intake and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α (PPARGC1A) rs4235308 Polymorphism in Relation to the Risk of Type 2 Diabetes in Cuban American Population. L. Xu, A. Cheema, G.G. Zarini, T. Li, F.G. Huffman. Florida International University and Nova Southeastern University. C254 I 644.17 Correlation of mRNA Levels with CpG Methylation Status of Genes Regulated by Fatty Acids in Differentiated Adipocytes. Y. Li, E. Cheng, B. Bower. Texas A&M University-Kingsville. C255 II 644.18 Epigenetic Regulation of Tumor Necrosis Factor (Tnf) in Skeletal Muscle by Chronic Caloric Restriction. D. Hernandez-Saavedra, Z.J. Goldberg, A.P. Wang, H. Chen, Y. Pan. University of Illinois at Urbana-Champaign. C256 I 644.19 Meta-Analysis of 19,005 Individuals Identifies Interplay Between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome, to Modulate Insulin Resistance and Diabetes Risk. A.M. Murphy, L. Murphy, C.E. Smith, J. Follis, T. Tanaka, M. Helminen, R. Lemaitre, T. Voortman, A. Dehghan, D. Mook-Kanamori, E. Marouli, K. Richardson, J. Dupuis, J. Meigs, P. O’ Gaora, J. Ordovas, H. Roche. University College Dublin, Ireland, Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University., Department of Mathematics, University of St. Thomas, Houston, Translational Gerontology Branch, National Institute on Aging, Baltimore, School of Health Sciences, University of Tampere, Finland, Department of Medicine, University of Washington, Department of Epidemiology, Erasmus MC University Medical Center, Netherlands, Department of Epidemiology, Erasmus MC-University Medical Center, Netherlands, Department of Clinical Epidemiology, Leiden University and Medical Centre, Netherlands, William Harvey Research Institute, The London School of Medicine and Dentistry, United Kingdom, Department of Biostatistics, Boston University School of Public Health, Division of General Internal Medicine and Massachusetts General Hospital. C257 II 644.20 Regulation of Endogenous Dusp4 by Agonist-Specific MAPK Activation in Adipocytes. W. Guo, B.S. Ferguson, R.F. Morrison. University of North Carolina Greensboro. C258 I 644.21 Characterization of Stability of the Young Porcine Intestinal Alkaline Phosphatase as a Candidate Exogenous Biocatalyst. T. Archbold, N.A. Burello, W. Wang, D.P. Bureau, M.Z. Fan. University of Guelph, Canada. C259 II 644.22 Sugar-Sweetened Beverage Intake as a Modulator of Genetic Associations for Chronic Inflammation Relevant to Cardiovascular Disease. D.C. Bartone, N.M. McKeown, K.R. Morrish, C.E. Smith, C. Lai, L.D. Parnell, J.M. Ordovas. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Friedman School of Nutrition Science and Policy, United States Department of Agriculture, Agricultural Research Service and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
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C260 I 644.23 Oncostatin M Regulation of Adipocyte Differentiation Through Cell Cycle Arrest in 3T3-L1. D.M. DeSilva, R.F. Morrison. University of North Carolina Greensboro. C261 II 644.24 Dietary Effects on A2AR Expression in Liver and Adipose Tissues: A Role for A2AR in Protecting Against Inflammation and Insulin Resistance in Obesity. Y. Pei, Y. Cai, H. Li, S. Woo, M. Liu, Y. Huo, C. Wu. Texas A&M University and Augusta University.
645. AGING AND NUTRITION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C262 I 645.1 Effects of Protein Supplementation on Frailty and Sarcopenia in Pre-Frail and Frail Elderly: Study Protocol for a Dose-Response, Double-Blind, Randomized Placebo-Controlled Trial. Y. Park, S. Kwon. Hanyang University, Republic of Korea. C263 II 645.2 The Effects of Age on the Gut and Brain: Insights Into the Gut-Brain Axis. J. Hoffman, V. Bakshi, I. Parikh, J. Guo, R. Armstrong, S. Green, A. Lin. University of Kentucky and University of Illinois at Chicago. C264 I 645.3 The Relation of Dietary Pattern and Telomere Length Among Adults in South China. H. Xue, G. Tian, D. Li, J. Zhang, G. Cheng. Sichuan University, People’s Republic of China. C265 II 645.4 Association Between Dietary Protein Intake and Grip Strength Among Adults Aged 51 Years and Over: What We Eat in America, National Health and Nutrition Examination Survey 2011–2014. S. Mishra, J.D. Goldman, N.R. Sahyoun, A.J. Moshfegh. University of Maryland and Beltsville Human Nutrition Research Center. C266 I 645.5 Evidence Mapping: Dietary Fiber Interventions and Bone Health Outcomes. K.M. Rancaño, D. Haslam, C.M. Sawicki, K.A. Livingston, S. Sahni, M. Chung, N.M. McKeown. Friedman School of Nutrition Science and Policy, Tufts University, JM USDA HNRCA at Tufts University, Musculoskeletal Research, Institute for Aging Research at Harvard Medical School, Department of Public Health and Community Medicine and School of Medicine at Tufts University. C267 II 645.6 The Effects of Soy Protein Supplementation on Lipid Profiles and Bone Biomarkers. K.S. George, S.A. Johnson, S. Pourafshar, N. Navaei, B.H. Arjmandi. Florida State University and Colorado State University. C268 I 645.7 Serum Phosphate (sPO4) Is Lower in Older Kidney Transplant Recipients and Related to Low Phosphorous and Protein Intake and Not Urinary Losses. S. Mincer, E. Ruff, M. Markell. SUNY Downstate Medical Center. C269 II 645.8 Evaluation of Antioxidant Activity of Umbelliferae Plants. J. Lee, Y. DIng, J. Kim. Kongju National University, Republic of Korea.
SUNDAY NUTRITION C270 I 645.9 Genistein in Combination with Fructooligosaccharides Prevents Bone Loss in Ovariectomized Rats. S. Pourafshar, N. Navaei, S.A. Johnson, S.C. Chai, S. Hooshmand, B.H. Arjmandi. Florida State University, Center for Advancing Exercise & Nutrition Research on Aging, Florida State University, Colorado State University, University of Delaware and San Diego State University. C271 II 645.10 Regular Apple Consumption Improves Lipid Profiles in Overweight Postmenopausal Women. N. Navaei, S. Pourafshar, S.A. Johnson, S. Hooshmand, S.C. Chai, B.H. Arjmandi. Florida State University, Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Colorado State University, San Diego State University and University of Delaware. C272 I 645.11 Dietary Pattern Associated with Frailty: Results from Nutrition and Health Survey in Taiwan. W. Pan, Y. Lo. Institute of Biomedical Sciences and Academia Sinica, Taiwan. C273 II 645.12 Protein Fortification of a Typical Biscuit Recipe. M.E. Johnson, E.M. Cress, K. Riddle, K. Webb, W.A. Clark. East Tennessee State University. C274 I 645.13 Dried Plum Consumption Modulates Bone Turnover Biomarkers in Postmenopausal Women with Osteopenia. N.S. Akhavan, R.L. Saadat, S. Hooshmand, S.C. Chai, S.A. Johnson, S. Pourafshar, B.H. Arjmandi. Florida State University, Center for Advancing Exercise and Nutrition Research on Aging, San Diego State University, University of Delaware and Colorado State University. C275 II 645.14 Alaskan Berry Treatments Maintain C. elegans Motility and Sarcomere Integrity with Age. F. Touray Jr, M. Maulik, C. Scerbak, E. Vayndorf, A. Bult Ito, B. Taylor. University of Alaska Fairbanks, Earlham College, California State University at Long Beach. C276 I 645.15 Effects of Dried Plum and Chokeberry on D-Galactose-Induced Aging Model. O. Jeong, H. Jeong, Y. Liu, H. Kim. Sookmyung Women’s University, Republic of Korea. C277 II 645.16 Studies on the Storage Life of Almond Nut (Prunus amygdala var dulcis) Milk Using Pawpaw (Carica papaya) Extract as Local Preservative. I. Banjoko, O. Oyelola, O. Olatidoye, J. Oyegbola. Yaba College of Technology, Nigeria. C278 I 645.17 The Effects of Ipriflavone, Isoflavone, and 17B-Estradiol on Body Composition in Hamster Models of Ovariectomy. E.M. Foley, S. Pourafshar, N. Navaei, N.S. Akhavan, K.S. George, B.H. Arjmandi. Florida State University and Center for Advancing Exercise and Nutrition Research on Aging. C279 II 645.18 Effect of Long-Term Supplementation Lactobacillus paracasei on Body Composition in SenescenceAccelerated Mouse P8 (SAMP8). L. Li, C. Chan, C. Kuo, W. Chen, H. Ku, Y. Lian, H. Huang. Shin Chien University, Taiwan and Tatung University, Taiwan. C280 I 645.19 Long Term Probiotics administration Alleviates Immunosenescence in Senescence-Accelerated Mouse Prone 8 (SAMP8). C. Kuo, C. Chan, L. Li, W. Chen, H. Ku, Y. Lian, H. Huang. Shih Chien University, Taiwan and Tatung University, Taiwan. C281 II 645.20 Age-Related Decrease of Neurotransmitters in Senescence-Accelerated-8 Mice. C-H. Chan, L-A. Li, C-Y. Kuo, W-L. Chen, Y-Z. Lian, H-H. Ku, H-Y. Huang. Shih Chien University, Taiwan and Tatung University, Taiwan.
C282 I 645.21 Potential Skin Anti-Aging Effects of Korean Medicinal Plant Extracts. J.N. Averilla, J. Kim, S. Ju, J. Oh, J. Kim. Kyungpook National University, Republic of Korea. C283 II 645.22 Male and Female Sex Hormones Modulate the Effects of Hepatic Rictor Deletion on Glucose Metabolism and Lifespan. S.I. Arriola Apelo, C.P. Pumper, M.T. Morrison, E.J. Meyer, N.E. Cummings, A. Lin, E.L. Baar, D.W. Lamming. University of Wisconsin-Madison. C284 I 645.23 The Effect of Dietary Protein Levels and Branched-Chain Amino Acid Supplementation on Body Composition of Aging C57BL/6 Male Mice. W. Mu, E. Vanhoosier, E. Jiang, R. Grant. Purdue University. C285 II 645.24 Decreased Consumption of Specific Macronutrients Promotes Metabolic Health and Longevity. N.E. Cummings, A. Radcliff, A. Brodbeck, E. Konon, J. Wu, D. Sherman, E. Williams, S. Arriola Apelo, M. Barnes, T. Hacker, D. Lamming. University of Wisconsin-Madison. C286 I 645.25 Prevalence of Lactose Intolerance in Patients on Proton-Pump Inhibitors. S. Rana, P. CR, A. Malik, S.K. Sinha, R. Kochhar. Post Graduate Institute of Medical Education and Research, India.
646. DIETARY BIOACTIVE COMPONENTS I Poster (Sponsored by: Dietary Bioactives Components RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C287 I 646.1 A Targeted UHPLC-MS Approach to Quantify Phenolics in Muscadine Grape Supplements. A.V. Duncan, N.T. Pirro, A. Tallant, P.E. Gallagher, M.C. Chappell. Wake Forest School of Medicine. C288 II 646.2 The Gaps Between Nutrition Support Guidelines and the Applications of Parenteral Nutrition. T. Bayrak, H. Kiehl, C. LaSalle. San Jose State University and Santa Clara Valley Medical Center. C289 I 646.3 Phenolic Compounds as Functional Ingredients and Nutraceuticals: The Case of Juice PLUS+. D. Del Rio, L. Bresciani. University of Parma, Italy. C290 II 646.4 The Role of the Gut Microbiome in Quercetin Inhibition of Sulforaphane Bioavailability and Bioactivity in Rats. Y. Wang, X.C. Liu, T. Becker, S.M. Song, J.A. Juvik, M.J. Miller, E.H. Jeffery. University of Illinois. C291 I 646.5 Identification of Metabolite Markers of Long-Term Green Tea Polyphenol Intake in Humans. Y. Zhou, N. Zhang, A. Arikawa, C. Chen. University of Minnesota Twin Cities and University of North Florida. C292 II 646.6 The Effect of Daily Soy Isoflavone Supplementation for One Year on Endogenous Steroid Metabolism in Healthy Postmenopausal Women. L. Wang, N.W. Gaikwad, F.M. Steinberg. University of California at Davis. C293 I 646.7 Hypoglycaemic and Hypolipidemic Effect of Standardized Small Millet (Paspalum scrobiculatum, Panicum miliare, Setaria italica) Incorporated Cookies Fed Rats. K. Packiyam, M. Durairaj, V. Nachimuthu. Sethu Bhaskara Agricultural College and Research Foundation, India and Tamil Nadu Agricultural University, India.
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NUTRITION SUNDAY C294 II 646.8 Use of Spot Urine Caffeine and Caffeine Metabolite Concentrations for Distinguishing a Recommended Upper Limit of Caffeine Intake. M.E. Rybak, M.R. Sternberg, C. Pao. CDC. C295 I 646.9 Polyphenol Antioxidants Bind Irreversibly to Protein Under Oxidative Conditions. X. Sun, M.T. Engstrom, J. Salminen, A.E. Hagerman. Miami University and University of Turku, Finland. C296 II 646.10 The Synergistic Anti-Obesity Effect of Gelidium elegans Extract and Orlistat in Vivo and in Vitro. S. Choi, M. Park, J. Choi, E. Koh, Y. Seo, J. Song, S. Chei, J. Hwang, Y. Lee, B. Lee. CHA University, Republic of Korea. C297 I 646.11 Atorvastatin Decreases Menaquinone-4 Formation in C57Bl6 Male Mice. S.G. Harshman, M.K. Shea, X. Fu, D. Smith, M.A. Grusak, S. Lamon-Fava, A.S. Greenberg, A. Kuliopulos, S.L. Booth. Tufts University and USDA/ARS Children’s Nutrition Center. C298 II 646.12 Gut Microbiota Dictate Metabolic Fate of Curcumin in the Colon. Z. Li, Y. Sun, M. Song, F. Li, H. Xiao. University of Massachusetts Amherst. C299 I 646.13 Absorption and Metabolism of Isothiocyanates Formed from Broccoli Glucosinolates: Effects of Daily Consumption. C. Charron, B. Vinyard, S. Ross, H. Seifried, E. Jeffery, J. Novotny. U.S. Department of Agriculture, National Cancer Institute and University of Illinois. C300 II 646.14 Adaptation of Galloyl Derivatives Metabolism and Excretion After 42 Days of Mango (Mangifera indica L.) Consumption. S.U. Mertens-Talcott, H. Kim, S.T. Talcott, R. Barnes. Texas A&M University. C301 I 646.15 The Combined Application of the Caco2 Cell Bioassay Coupled with In Vivo (Gallus gallus) Feeding Trial Represents an Effective Approach to Predicting Fe Bioavailability in Humans. E. Tako, H. Bar, R.P. Glahn. USDAARS, Robert W. Holley Center for Agriculture and Health and University of Connecticut. C302 II 646.16 Fabrication of Lysozyme/Artemisia sphaerocephala Krasch Seed Polysaccharide Nanoparticles for the Encapsulation and Protection of Curcumin. D. Ren, J. Qi, A. Xie, X. Yang, H. Xiao. Shaanxi Normal University, People’s Republic of China, and University of Massachusetts. C303 I 646.17 Ingested Walnut Oil Can Prevent LowFat/High-Carbohydrate Diet and High-Fat Diet-Induced Obesity by Modulating Metabolic Health Markers and Regulating the Expression of Genes for Metabolism. V. Juturu, K. Sahin, C. Orhan, M. Tuzcu, N. Sahin. OmniActive Health Technologies Inc and Firat University, Turkey. C304 II 646.18 Dietary Mango Ginger May Enhance the Exercise Performance and Reduces Lipids When Combined with Treadmill Running: In Vivo Model. K. Sahin, M. Tuzcu, C. Orhan, N. Sahin, F. Akdemir, R. Pala, V. Juturu. Firat University, Turkey and OmniActive Health Technologies Inc. C305 I 646.19 Avenanthramides and Their Microbial Metabolites as the Urinary Exposure Markers for Whole Grain Oat Intake: A Kinetic Study in Human. S. Sang, P. Wang, A. Yerke. North Carolina A&T State University. C306 II 646.20 Metabolic Fate of Blueberry Anthocyanins After Chronic Supplementation in Healthy Older Adults. A. Sandhu, M.G. Miller, B. Shukitt-Hale, I. Edirisinghe, B. Burton-Freeman. Illinois Institute of Technology and USDA-ARS Human Nutrition Research Center on Aging at Tufts University.
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C307 I 646.21 Detection of Mature Plant miRNA in Different Biological Matrix: Importance of Internal Standard and Validation of the Method. H. Huang, J. Roh, C.D. Davis, T.T. Wang. USDA-ARS and NIH. C308 II 646.22 Targeting Inflammation and Synaptic Plasticity with Bioactive Polyphenol Metabolites Promotes Resilience Against Stress Disorder and Depression. G.M. Pasinetti. Icahn School of Medicine at Mount Sinai. C309 I 646.23 Role of Gut Microbiota-Derived Polyphenolic Acid in Attenuation of Protein Misfolding in Neurodegeneration. G.M. Pasinetti, L.M. Ho, J.M. Faith, K.M. Ono. Icahn School of Medicine at Mount Sinai. C310 II 646.24 Microbiome Analysis of the Refaunation of Donor Human Milk with Mom’s Own Milk. N. Harrison, N. Cacho, L. Carr, N. Li, L.A. Parker, J. Neu, G.L. Lorca. University of Florida. C311 I 646.25 Identification of Glycoproteins on the Surface of Bovine Milk Exosomes and Intestinal Cells That Facilitate Exosome Uptake in Human Colon Carcinoma Caco-2 Cells. S. Sukreet, H. Zhang, J. Adamec, J. Cui, J. Zempleni. University of Nebraska -Lincoln and University of Nebraska-Lincoln. C312 II 646.26 The Protective Effects of ProbioticFermented Soymilk on High-Fat Diet-Induced Hyperlipidemia. Y. Wang, C. Piao, J. Liu, H. Yu, W. Dai, X. Wang. Jilin Agricultrual University, People’s Republic of China, Jilin Agricultural University, People’s Republic of China. C313 I 646.27 Targeted Delivery of Resveratrol to Mouse White Adipose Tissue Using Adipose Stromal Cells (ASC) Targeted Nanoparticles. Y. Zu, S. Wang. Texas Tech University. C314 II 646.28 Change in Plasma Phospholipid Fatty Acids Over 13 Years and Determinants of Change: EPIC-Norfolk Study. F. Imamura, S.J. Sharp, Z. Ye, A. Koulman, J. Griffin, R. Luben, J. Zheng, K. Khaw, N.J. Wareham, N.G. Forouhi. MRC Epidemiology Unit, University of Cambridge, United Kingdom, MRC Elsie Widdowson Laboratory, United Kingdom, Department of Biochemistry, University of Cambridge, United Kingdom, Department of Public Health and Primary Care and University of Cambridge, United Kingdom. C315 I 646.29 In Silico Screening and Usability of Molecular Modeling in Finding Bio-Active Compounds in Diet Components: Investigation of Javamide-I/-II/-III and Chlorogenic Acids Found in Coffee and Flavonoids as p38 MAP Kinase Inhibitors. J. Park. BHNRC. C316 II 646.30 Synthetic Lethality of K-Ras Mutant Human Colorectal Cancer Cells by Phytochemical Curcumin and Fda-Approved Targeted Drug Regorafenib. C. Su, C. Wu. National Taiwan Normal University, Taiwan. C317 I 646.31 Comparative Effect of an AnthocyaninRich Extract from Purple Corn and Pure Anthocyanins on 3T3-L1 Adipocytes Under Different Physiological Conditions. D.A. Luna-Vital, M. Weiss, E. Gonzalez de Meija. University of Illinois. C318 II 646.32 Advanced Glycation End Products (AGEs) and sRAGE Levels After Benfotiamine Treatment in Diabetes Mellitus Type 2. C. Luevano Contreras, I. GuzmanRosiles, D. Del Castillo, A. Gomez-Ojeda, M. Garay-Sevilla. University of Guanajuato, Mexico and Spanish National Research Council, Spain.
SUNDAY NUTRITION C319 I 646.33 Phenolics from Wholegrain Oat Products as Modifiers of Starch Digestion and Intestinal Glucose Transport. M. Li, L. Hansen, K. Koecher, M.G. Ferruzzi. North Carolina State University, Purdue University and General Mills Inc. C320 II 646.34 Utilizing Phytonutrients for Public Health and Establishing Global Phytonutrient Society (GPS). H. Amagase, T. Miyazawa, K. Nakagawa, S. Kato. Amway Japan, Japan, Association of International Food and Nutrition, Japan, Global Phytonutrient Society, Japan and Tohoku University, Japan. C321 I 646.35 Dietary Delta-Tocotrienol Favors Abundance and Diversity of Beneficial Microbiomes in Obese Male Mice. C. Shen, R. Kottapalli, M.D. Tomison, I. Koboziev, C.R. Web, L. Ramalingam, N. Moustaid-Moussa, G. Kaur, J. Dufour, E. Chung, H. Mo, M.R. Grisham. Texas Tech University Health Sciences Center, Texas Tech University, University of Texas at San Antonio and Georgia State University. C322 II 646.36 A Combination of Herbal Extracts Targets Prostate Cancer by Upregulating AMPK Through the Tumor Suppressor Protein LKB1. A. MacDonald, D. Donohoe, A. Bettaieb, A. Han, Y. Zhao, J. Whelan. University of Tennessee. C323 I 646.37 Molecular Docking Study and Evaluation of the Anti-Diabetic Complications of Dihydroxanthyletin-Type Coumarins from Angelica decursiva. H. Jung, M.Y. Ali, S. Jannat, S.K. Park, J.S. Choi. Chonbuk National University, Republic of Korea, Pukyong National University, Republic of Korea. C324 II 646.38 Black Bean Coat Anthocyanin-Rich Extracts and Pure Anthocyanins Modulated Molecular Markers of Diabetes. L. Mojica, M. Berhow, E. Gonzalez de Mejia. Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C, Mexico, University of Illinois, United States Department of Agriculture and Agricultural Research Service. C325 I 646.39 Role of Estrogen Receptor Alpha in Protective Effects of Soy in Adipose Tissue Following Ovariectomy. L.T. McCabe, T.M. Zidon, R.J. Welly, J.W. Porter, N.C. Winn, O.E. Stricklin, M.L. Gastecki, D.B. Lubahn, J. Padilla, V.J. Vieira-Potter. University of Missouri. C326 II 646.40 Protective Effect of Anthocyanin on Alcohol Induced Liver Fibrosis Is Due to the Regulation on AMPK/mTOR/Autophagy Pathway and Energy Status. L. Yang, T. Wan, S. Wang, M. Ye, L. Pei, R. Jiang, Y. Qiu. School of Public Health, Sun Yat-sen University, People’s Republic of China. C327 I 646.41 Strawberries Improve Pain Symptoms in Obese Participants with Radiographic Evidence of Knee Osteoarthritis. J. Schell, D. Christiansen, J. Barrett, E. Lohrman, N. Betts, Y.D. Zhao, J. James, H. Scofield, A. Basu. Oklahoma State University, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation. C328 II 646.42 Se-Allylselenocysteine Suppresses Inflammation via Inhibiting iNOS Expression. A. Cheng, M. Lee, M. Pan. Chang Jung Christian University, Taiwan and National Taiwan University, Taiwan. C329 I 646.43 Pterostilbene Inhibits Adipocyte Differentiation by Targeting CHOP10 in 3T3-L1. K. Kim, Y. Seo, E. Koh, J. Choi, J. Hwang, Y. Lee, J. Song, S. Chei, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea.
C330 II 646.44 A Date Palm Extract Modulates Nuclear Receptor-Mediated Transactivation in Vitro. M. Ricketts, E. Alfaro-Viquez, J. Reed, C. Krueger, C. Rainey. University of Nevada Reno, University of Wisconsin-Madison, Complete Phytochemical Solutions and Date Research Institute. C331 I 646.45 Polyphenol-Rich Extract of Syzygium cumini Leaf Reduces Non-Alcoholic Fatty Liver Disease in MSG-Obese Mice by a Joint Action on Insulin Resistance and Endoplasmic Reticulum Stress. L.M. França, P.C. dos Santos, K.T. Flister, C.C. Vale, J.R. Sanches, R.A. Benevides, N.L. Xavier Ribeiro, F.M. Laurindo, A.d. Paes. Federal University of Maranhão, Brazil and University of São Paulo, Brazil. C332 II 646.46 Genistein and Daidzein Influence Lipid Metabolism in Human and Murine Cells via Liver X Receptor. T.F. Luo, N.F. Shay. Oregon State University. C333 I 646.47 Effects of Sulforaphane in the Tumor Microenvironment of Triple-Negative Breast Cancer. E. Slattery, T. Cline, L. Housley. California State University at Chico. C334 II 646.48 3R, 3′R Zeaxanthin Protects Retina from Photo-Oxidative Damage: in Vivo Model. N. Sahin, F. Akdemir, C. Orhan, M. Tuzcu, I. Yilmaz, V. Juturu. Firat University, Turkey, Inonu University, Turkey and OmniActive Health Technologies Inc. C335 I 646.49 Green Tea Extract Protects Against Hepatic NFκB Activation Along the Gut-Liver Axis in DietInduced Obese Mice with Nonalcoholic Steatohepatitis by Reducing Endotoxin and TLOR4/MyD88 Signaling. J. Li, C. Chitchumroonchokchai, J.B. Kim, G.Y. Sasaki, M.V. Moller, J.A. Bouranis, R.S. Bruno. The Ohio State University. C336 II 646.50 Chronic Effects of an Olive Leaf Extract on Sucrose Hydrolysis and Transport in the Caco-2/TC7 Model of the Small Intestine. A.H. Pyner, S. Tumova, S. Gardner, A. Kerimi, L. McKeown, G. Williamson. University of Leeds, United Kingdom. C337 I 646.51 Genistein in Combination with Sulforaphane for the Treatment of Type 2 Diabetes. D. Liu, A. Wang, J. Liu, H. Alkhalidy, W. Zhen, W. Moore. Virginia Tech. C338 II 646.52 Flavonol Kaempferol Improves Glucose Homeostasis via Suppressing Hepatic Glucose Production and Enhancing Insulin Sensitivity in Diabetic Mice. W. Moore, H. Alkhalidy, K. Zhou, D. Liu. Virginia Tech and Wayne State University. C339 I 646.53 Mechanisms Mediating Effects of Eicosapentaenoic Acid in Hepatic Steatosis in High Fat Fed Mice and in HepG2 Hepatoma Cells. S.M. Gonzalez, K.M. Albracht-Schulte, L. Ramalingam, N.S. Kalupahana, N. Moustaid-Moussa. Texas Tech University, University of Peradeniya and Sri Lanka, Sri Lanka. C340 II 646.54 25-Hydroxyvitamin D Elicits HormoneLike Response in Intestinal Epithelium. C. Reynolds, N. Koszewski, R. Horst, D. Beitz, J. Goff. Iowa State University and Heartland Assays. C341 I 646.55 Effect of Resveratrol in Methylation Promoter of FNDC5 Gene in Skeletal Muscle and Adipose Tissue. V. Heredia-Lugo, P. Garcia-Tobilla, M. Rodriguez, B. Palacios. Instituto Nacional de Medicina Genomica, Mexico.
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NUTRITION SUNDAY C342 II 646.56 The Effect of a High-Fat Diet and Green Tea Extract on Glucose Metabolism and Inflammation in Regulator of G Protein Signaling 10 Knockout Mice. H. Park, E. Olsen, X. Fang, J. Dagher, J. Chung, S. Kang, J. Lee. University of Georgia. C343 I 646.57 Effects of Dietary Pomegranate Extract and Inulin in Mice Fed an Obesogenic Diet. J. Yang, S. Zhang, S.M. Henning, R. Lee, M. Hsu, E. Grojean, R. Pisegna, A. Ly, D. Heber, Z. Li. University of California Los Angeles. C344 II 646.58 Bitter Receptors Control Glucose Absorption in the Gut by Modifying the G-Protein Coupled Receptor Signaling Cascade. K.M. Palatini ‘Jackson, T. Rathinasabapathy, S. Bonney, D. Esposito, S. Komarnytsky. North Carolina State University, Plants for Human Health Institute, North Carolina State University, International Medical University and School of Pharmacy, Malaysia. C345 I 646.59 Cornus officinalis Polyphenols Reduce Senescence of Vascular Cells by Modulating the Antioxidant Response. G. Salazar, H. Morgan, R.G. Feresin, D K.S. Klarich. Florida State University and University of Arkansas for Medical Sciences. C346 II 646.60 Plant Polyphenol Extract Regulated Diacylglycerol Acyltransferase and Tristetraprolin Gene Expression in Cultured Mouse Cells. H. Cao, K. Sethumadhavan, R. Anderson. USDA-ARS. C347 I 646.61 Blueberry Metabolites Restore Composition of Glycosaminoglycan Structures in Diabetic Human Vascular Endothelial Cells. B. Cutler, J. Chua, B. Kuberan, A. Pon Velayutham. University of Utah. C348 II 646.62 Muscadine Grape Extract Prevents Proliferation of HER2 Positive Breast Cancer Cells in Association with a Decrease in Phosphorylation of AKT and mTOR. J.D. Mackert, E. Tallant, P.E. Gallagher. Wake Forest School of Medicine. C349 I 646.63 Epigenetic Regulation of WNT and Hedgehog Oncogenic Signaling in Breast Cancer Cells in Response to Dietary Polyphenols. B. Stefanska, L. Kurzava, K. Lubecka, M. Beetch, K. Flower, J.M. Flanagan. Purdue University and Imperial College London, United Kingdom.
647. RESEARCH WITH DIETARY SUPPLEMENTS AND BIOACTIVE COMPONENTS Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C350 I 647.1 Dietary Supplement Use in All United States Military Services. J.J. Knapik, K.G. Austin, D.W. Trone, E.K. Farina, R.A. Steelman, H.R. Lieberman. US Army Research Institute of Environmental Medicine, US Army Public Health Command, Naval Health Research Center and US Army Public Health Center.
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C351 II 647.2 Moringa Leaf Powder Modulates Reverse Cholesterol Transport Without Changing Plasma Lipids in Guinea. G. Murillo, M. Almatrafi, M. VergaraJimenez, M. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and University of Sinaloa, Mexico. C352 I 647.3 Usual Intakes of Flavonoids: Estimates from What We Eat in America, NHANES 2007–2010. R.S. Sebastian, J.D. Goldman, C. Wilkinson Enns, A.J. Moshfegh. ARS and USDA. C353 II 647.4 The Iron Paradox: Discrepancies in Iron Chemical Forms Found in Prenatal Supplements and Tested in Clinical Trials. L. Saldanha, J. Dwyer, L. Brown, K. Andrews, P. Gusev, P. Pehrsson. Office of Dietary Supplements, NIH and Agricultural Research Service, USDA. C354 I 647.5 The Effect of Fish Oil Supplementation on Brain DHA and EPA Content and Fatty Acid Profile. K.J. Valentini, C.A. Pickens, J.A. Wiesinger, J.I. Fenton. Michigan State University. C355 II 647.6 Caffeine Intake Is Associated with Lifestyle Factors and Measures of Perceived Health in US Children: Findings from NHANES 2007–2012. N. Ahluwalia, S.M. Frenk. CDC, National Center for Health Statistics and Division of Health and Nutrition Examination Surveys. C356 I 647.7 Effects of Ginkgo Biloba Intake on Markers of Liver Function in a Large Representative Sample of the U.S. Population. S. Agarwal, H.R. Lieberman, V.L. Fulgoni; III. ORISE, U.S. Army Research Institute of Environmental Medicine and Henry M. Jackson Foundation. C357 II 647.8 A Comparison of Labeled Nutrients with Respect to Recommended Amounts in Toddler Dietary Supplements. L. Saldanha, L. Brown, C. Brasseux, R. Bailen, J. Dwyer, A. Ershow. ODS/NIH and Cornell University. C358 I 647.9 Impact of Walnut Supplementation on Dietary Change for Weight Loss. E. Neale, M. Batterham, L. Tapsell. University of Wollongong, Australia. C359 II 647.10 Hepatoprotective Effect of Centella asiatica Extract (ECa233) in Rotenone-Induced Liver Injury Rats. R.Tansawat,T. Intararuchikul, R. Rodsiri, K. Meksawan, W. Warisnoicharoen. Chulalongkorn University, Thailand. C360 I 647.11 Addition of a Snack of Lupinus mutabilis Sweet to the Conventional Treatment with Metformin in the Control of Type-2 Diabetes. M.E. Baldeon, M. Fornasini, A. Hidalgo, L. Masabanda, J. Castro, M. Tufiño, E. Villacrés. Universidad Tecnológica Equinoccial, Ecuador, Universidad de las Américas, Ecuador, Unidad Municipal de Salud Norte Patronato San José, Ecuador, Instituto Nacional Autónomo de Investigaciones Agropecuarias and INIAP, Ecuador. C361 II 647.12 Effect of Sulfur-Containing Compounds on Hydrogen Sulfide Production in THP-1 Differentiated Macrophages. C. Rodrigues, E. Fereyduni, A.J. Grenning, C.A. Rowe, S.S. Percival. University of Florida. C362 I 647.13 Dietary Supplement Items on Commonly Used Food Frequency Questionnaires. L. Rios-Avila, J. Dwyer, R. Costello, N. Potischman. National Institutes of Health.
SUNDAY NUTRITION C363 II 647.14 Analytically Predicted Estimates for Vitamin D, Vitamin a and Chromium Content in Adult Multivitamin/Mineral Products (MVMs) for the Dietary Supplement Ingredient Database (DSID). K.W. Andrews, P.A. Gusev, P.V. Dang, S. Savarala, L.Y. Oh, P.R. Pehrsson, J.T. Dwyer, J.M. Betz, R.B. Costello, L.G. Saldanha, L.W. Douglass. ARS-USDA, ODS-NIH and Consulting Statistician. C364 I 647.15 Do Single- And Multi-Ingredient Botanical Dietary Supplements Containing Green Tea Pass the United States Pharmacopeia’s (USP) Disintegration and Dissolution Requirements? P.A. Gusev, K.W. Andrews, S. Savarala, P.V. Dang, L.Y. Oh, P.R. Pehrsson, J.T. Dwyer, J.M. Betz, R.B. Costello, L.G. Saldanha, A.J. Kuszak. ARS-USDA and ODS-NIH. C365 II 647.16 Total Usual Intake of Most Shortfall Nutrients Varies with Poverty Among U.S. Adults. R.L. Bailey, S.R. Akabas, E.E. Paxon, S. Saklani, S.V. Thuppal, K.L. Tucker. Purdue University, Columbia University and University of Massachusetts Amherst.
648. ADVANCING NUTRITIONAL EPIDEMIOLOGY WITH PUBLIC USE AND COMMERCIAL DATA SETS Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C366 I 648.1 Time Trends and Patterns of Reported Egg Consumption in the U.S. by Sociodemographic Characteristics. L. Jahns, Z. Conrad, L.K. Johnson, J.N. Roemmich, W. Juan. USDA-ARS Grand Forks Human Nutrition Research Center and FDA Center for Food Safety and Applied Nutrition. C367 II 648.2 Snacking Trends in US Adults Over a 35 Year Period from 1977–2012. E. Dunford, B. Popkin. Carolina Population Center, The University of North Carolina at Chapel Hill and The George Institute for Global Health, Australia. C368 I 648.3 Impact of Usual Intake of Added Sugars on Nutrient Adequacy: NHANES 2009–2012. T. Nicklas. Baylor College of Medicine. C369 II 648.4 Association of Added Sugars Intake with Physiologic Parameters in Adults: NHANES 2001–2012. C.E. O’Neil, T.A. Nicklas, V.L. Fulgoni III. Louisiana State University, Baylor College of Medicine and Nutrition Impact. C370 I 648.5 American Adults Meeting the 2015– 2020 Dietary Guidelines for Americans Added Sugars Recommendation: WWEIA, NHANES 2011–12. S.A. Bowman. USDA and Agricultural Research Service. C371 II 648.6 Can De-Identified Electronic Health Records Be Used to Describe Nutrition-Related Outcomes in a Cohort of Adolescent Women Attending Primary Care Facilities? M. Mclean, C.S. Jiang, A. Cheng, D. Moftah, J. Breslow, P.R. Holt, J.N. Tobin. The New York Academy of Sciences, The Rockefeller University and The Clinical Directors Network.
C372 I 648.7 Prepregnancy Body Mass Index Is Positively Associated with Dietary Inflammatory Index and C-Reactive Protein Concentrations During Pregnancy. D. Shin, K. Lee, J. Hur, H. Chung, N. Shivappa, M.D. Wirth, J.R. Hébert. University of North Dakota, Michigan State University, Hoseo University, Republic of Korea, University of South Carolina, Connecting Health Innovations and LLC. C373 II 648.8 The Association Between Dietary Fiber Intake and CRP Levels, US Adults, 2007–2010. S.J. Nielsen, M. Trak-Fellermeier, K. Joshipura. University of Pittsburgh and University of Puerto Rico. C374 I 648.9 Exploring Diabetes Care-Related Outcomes in Arkansas Healthcare Systems for Young Old (Ages 65–74) and Old (Ages 75–84) Age Groups. D. Bauerlein, J. Phelps, T. Crook, R. Hakkak. University of Arkansas for Medical Sciences. C375 II 648.10 What Do People Eat When They Don’t Eat Meat? An Evaluation of Dietary Quality Using the National Health and Nutrition Examination Survey (NHANES), 2007–2012. Z. Conrad, M. Karlsen, K. Chui, L. Jahns. US Department of Agriculture, Agricultural Research Service, Friedman School of Nutrition Science and Policy, Tufts University, School of Medicine and Tufts University. C376 I 648.11 Combining National Food Consumption Survey Data with a Bioactive Database in a Probabilistic Intake Model to Assess Bioactive Intakes in Europe—A Tool Resulting from the European Bacchus Project. S. Pigat, F. Bompola, M. Cushen, J. Plumb, P. Finglas. Creme Global, Ireland and Institute of Food Research, United Kingdom. C377 II 648.12 Mixed Dishes Are a Top Contributor to Vitamin K Intake in US Adults: Data from the 2011–2012 NHANES. S.G. Harshman, E.G. Finnan, K. Barger, R.L. Bailey, D.B. Haytowitz, S.L. Booth. Tufts University, Purdue University and Beltsville-HNRCA. C378 I 648.13 Yogurt Consumption Is Associated with Improved Nutrient Intakes, Diet Quality, Body Weight and Cardiometabolic Biomarkers in the US: Results from NHANES 2011–14 and the Food Patterns Equivalent Database. B. Garcia-Bailo, N. Jain, J. Smith, V. Benoit. Bell Institute of Health and Nutrition, General Mills and Inc. C379 II 648.14 The Dairy Food Group Contributes Essential Nutrients to the Diets of Children and Adults. C.J. Cifelli, J.A. Houchins, E. Demmer, V.L. Fulgoni; III. National Dairy Council, Nutrition Impact and LLC. C380 I 648.15 Legume Consumption, Diet Quality and Body Weight: Results from NHANES 2009–2012 and the Food Patterns Equivalent Database 2009–2012. B. Garcia-Bailo, N. Jain, C. Keeler, J. Smith. Bell Institute of Health and Nutrition, General Mills and Inc. C381 II 648.16 Associations of Birth-Related Factors with Adult Weight Status and Blood Pressure: Findings from the Longitudinal Framingham Offspring Cohort. N. Parekh, Y. Lin, J.L. Freudenheim, A. Deierlein. New York University College of Global Public Health, New York University School of Medicine, Rutgers School of Public Health, Rutgers Cancer Institute of New Jersey and University of Buffalo. C382 I 648.17 The Role of Ready-To-Eat Cereal Fortification in Nutrient Intakes Among Children and Teens: A Modeling Study Using NHANES 2011–2012. J. Smith, B. Garcia-Bailo, N. Jain, L. Shiery, C. Gugger. Bell Institute of Health and Nutrition, General Mills and Inc.
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NUTRITION SUNDAY C383 II 648.18 Patterns of Ready-To-Eat Cereal Consumption and Nutrient Intakes Among Ready-to-Eat Cereal Eaters: Results from NHANES 2013–2014 J. Smith, B. Garcia-Bailo, V. Vanage, L. Shiery. General Mills, Inc., Bell Institute of Health and Nutrition, General Mills and Inc. C384 I 648.19 Nutrition, Health and Economic Development Nexus in Sub-Saharan Africa: Evidence from Vector Auto Regression Models. S.S. Klobodu, J. Dawson, D. Reed, C. Carpio, N. Moustaid-Moussa, N. Velikova. Texas Tech University. C385 II 648.20 Objectively Collected Weight Data and Long-Term Outcomes: Analysis of Data from 90,000 Users of the Withings Smart Scale. L.J. Wilkinson, D. Levitsky. University of Alabama, Birmingham and Cornell University. C386 I 648.21 Socioeconomic Disparities in the Prevalence of Coexistence of Metabolic Syndrome and Osteopenia Among Postmenopausal Women in South Korea: The 2008–2011 Korea National Health and Nutritional Examination (KNHANES). H. Lee, H. Lim. Kyung Hee University, Republic of Korea. C387 II 648.22 Environmental Exposure to Cadmium Is Decreasing Among Adults and Children in the US. T.M. Vance. SUNY College at Plattsburgh.
649. CHILDHOOD NUTRITION EPIDEMIOLOGY Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C388 I 649.1 Monetary Diet Cost Is Positively Associated with Diet Quality: Analysis of School-Aged Children in South China. J. Zhang, H. Xue, D. Li, J. Yin, Y. Chen, G. Cheng. West China School of Public Health, Sichuan University, People’s Republic of China. C389 II 649.2 High Protein Intake Along with Paternal Part-Time Employment Is Associated with Higher Body Fat Mass Among Girls from South China. J. Luo, Yang, H. Xue, J. Pan, L. Libuda, R. Muckelbauer, M. Yang, G. Cheng. Sichuan University, People’s Republic of China, University of Duisburg-Essen, Germany and Charité—Universitätsmedizin Berlin, Germany. C390 I 649.3 Consumption of Mixed Dishes by American Children and Adolescents: An Analysis Beyond Calories, Saturated Fat and Sodium. J.A. Houchins, C.J. Cifelli, E. Demmer, V.L. Fulgoni III. National Dairy Council, Nutrition Impact and LLC.
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C391 II 649.4 What Children Eat and Drink in America: Changes Between 2003–2004 and 2013–2014. D.G. Rhodes, J.C. Clemens, A.J. Moshfegh. Agricultural Research Service and Beltsville Human Nutrition Research Center. C392 I 649.5 Is Soy Isoflavones Consumption Associated with Pubertal Onset in Boys? G.S. Siapco, P. Pribis, J. Sabate. School of Public Health, Loma Linda University, College of Education and University of New Mexico. C393 II 649.6 Nutritional Status of Brazilian Children from Acre and Rio Grande Do Sul States Assisted by “Bolsa Família” Program. M.J. Bortolini, A.G. Freitas, D.G. Lima, C.F. Silva, C.S. Bortolini, L.C. Abreu, D.U. Meneguetti, R.P. Silva. Federal University of Acre, Brazil and Faculdade de Medicina do ABC, Brazil. C394 I 649.7 Preterm Birth and Biomarkers of Environmental Enteric Dysfunction Among Infants in Tanzania. E. Liu, K.P. Manji, C.M. McDonald, K. Gosselin, R. Kisenge, W.W. Fawzi, A.T. Gewirtz, C.P. Duggan. Boston Children’s Hospital, Muhimbili University of Health and Allied Science, Tanzania, Children’s Hospital Oakland Research Institute, Harvard School of Public Health and Georgia State University. C395 II 649.8 Egg Consumption Is Associated with Greater Intake of Several Nutrients to Encourage, Lower Total and Added Sugar Intake and Improved Recumbent Length in Us Infants: Data from the National Health and Nutrition Examination Survey, 2001–2012. Y. Papanikolaou, V.L. Fulgoni. Nutritional Strategies, Canada and Nutrition Impact. C396 I 649.9 Dyslipidemia Among School-Age Children and Adolescents in Southern Provinces of China. J. Shi, L. Liu, H. Li, S. Du. Beijing Municial Center for Disease Control and Prevention, People’s Republic of China, and The University of North Carolina at Chapel Hill. C397 II 649.10 Pasta Consumption in American Children and Adolescents Is Associated with Greater Daily Intake of Shortfall Nutrients as Defined by the 2015–2020 Dietary Guidelines, Improved Diet Quality and Lower Added Sugar Intake. Y. Papanikolaou. Nutritional Strategies, Canada. C398 I 649.11 Egg Consumption Is Associated with Greater Intake of Several Nutrients to Encourage and Lower Total and Added Sugar in US Children and Adolescents. Y. Papanikolaou, V.L. Fulgoni. Nutritional Strategies, Canada and Nutrition Impact. C399 II 649.12 Blood Lead, Iron Deficiency and Attentional ADHD Symptoms in Uruguayan First-Graders. G. Barg, E.I. Queirolo, N. Mañay, F. Peregalli, K. Kordas. Catholic University of Uruguay, Uruguay, University of the Republic of Uruguay, Uruguay and University at Buffalo. C400 I 649.13 Relationship of Stunting and Overweight in Egyptian Children Under Five Years of Age: Trends and Associated Risk Factors. S. Ghosh, G. Namirembe, M. Moaz, A. Pokharel, E. Marino-Costello, J.K. Griffiths, P. Webb. Tufts and Helen Keller International, Nepal.
SUNDAY NUTRITION
650. LACTATION Poster Maternal, Perinatal and Pediatric Nutrition RIS Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C401 I 650.1 Adequacy and Sources of Total Daily Water and Liquid Drinks by Low-Income, Urban and Rural, Pregnant and Lactating Women in the Western Highlands of Guatemala. L.A. Diaz-Jereda, G. Montenegro-Bethancourt, M. Vossenaar, N.W. Solomons. CeSSIAM, Guatemala. C402 II 650.2 Comparative Evaluation of the Performance of Urinary Biomarkers of Hydration Status Among Lactating Women in the Western Highlands of Guatemala. H.B. Rolker, A. Maldonado, M. Soto-Méndez, A.B. MelseBoonstra, N.W. Solomons. Wageningen University, Netherlands and CeSSIAM, Guatemala. C403 I 650.3 Maternal Low-Protein Diet During Gestation Gender-Selectively Induces Amino Acid Response Pathway and Autophagy in the Liver of Offspring Rats. M. Cai, H. Wang, Y. Pan. University of Illinois at Urbana-Champaign. C404 II 650.4 Acceptability to Consumers of a Whey-Protein Concentrate Supplement When Added to Assorted, Customary Thin Gruels (Atoles) of Guatemala. M.L. Escobar, C.L. Arriaga, A. Maldonado, D. Fuentes, E. Diaz-Ruiz, R. García-Meza, M. Vossenaar, N.W. Solomons, D. Hirst, M.J. Bonorden. CeSSIAM, Guatemala and Hormel Foods Company. C405 II 650.5 Body Composition in Mothers of Infants According to the Type of Feeding. Preliminary Data. E. GuzmánMercado, E.M. Vasquez-Garibay, A. Larrosa-Haro, N. MuñozEsparza, N. Badillo, S. Apodaca, M. Mancilla-Madrid, E. Romero-Velarde. University of Guadalajara, Mexico. C406 II 650.6 Impact of Maternal Diet and Exercise on Human Milk Insulin. C. Burchenal, L. Barbour, T. Hernandez, J. Friedman, N. Krebs, B. Young. University of Colorado. C407 I 650.7 Quantity and Species of Fish Consumed Shapes Breast Milk Fatty Acid Concentrations Around Lake Victoria, Kenya. K.J. Fiorella, E.M. Milner, D.O. Omollo, M.D. Hickey, C. Salmen, E. Bukusi, L.C. Fernald. Cornell University, University of California, Berkeley, Organic Health Response-Ekialo Kiona Center, Kenya, University of California, San Francisco, University of Minnesota and Kenya Medical Research Institute, Kenya. C408 II 650.8 BMI-Based Prenatal Vitamins in Obese Pregnancy: Cohort Profile. S. Sen, A. Penfield-Cyr, C. Benjamin, M. Tynan, M. Herlihy, M. Hacker, T. McElrath. Brigham and Women’s Hospital, University of Rhode Island and Beth Israel Deaconess Medical Center. C409 I 650.9 Milk Production in Mothers with and Without Signs of Insulin Resistance. L.A. Nommsen-Rivers, S.A. Riddle, A. Thompson, L. Ward, E. Wagner. University of Cincinnati and Cincinnati Children’s Hospital.
C410 II 650.10 Associations Between Breastfeeding Intention and Accurate Body Size Estimation Among Female College Students. K.D. Powell, S. Colby, M.D. Olfert, W. Zhou, M. Spence, C. Springer, K. Kavanagh. University of Tennessee and West Virginia University. C411 II 650.11 Breastfeeding Knowledge, Attitudes, Prior Exposure and Intention of a Sample of Undergraduate Students in Honduras. M. Rendon, Z. Lou, M.L. Spence, M. Mejia, S.E. Colby, K.F. Kavanagh. University of Tennessee. C412 I 650.12 Pumping on Campus: Validity and Reliability of a Theory-Based Instrument to Assess Breastfeeding Behavior. L.M. Dinour, Y.K. Bai. Montclair State University. C413 I 650.13 Patterns of Breastfeeding at 3 Months Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study. M. Jarman, P.J. Robson, Y. Shen, M. Madsen, R.C. Bell, A. Study Team, E. Team. University of Alberta, Canada and Alberta Health Services, Canada. C414 II 650.14 The Relationships Between Maternity Practices and Exclusive Breastfeeding Rates in the Hospital. J.A. Patterson, N.S. Keuler, B.H. Olson. University of Wisconsin- Madison. C415 I 650.15 Peripheral Serotonin Deficiency May Assist Early Lactation Outcomes in Mice Fed a High-Fat Diet. A.A. Cheng, L.L. Hernandez. University of Wisconsin-Madison. C416 II 650.16 Disparities in Breastfeeding Outcomes Between Women Undergoing Medication-Assisted Treatment (MAT) for Substance Use Disorder (SUD) and Abstaining Controls. E.Y. Jimenez, N. Yonke, L.M. Leeman, S. Shrestha, S. Cano, L. Garrison, S. Williams, J. Stephen, L. Bakhireva. University of New Mexico and Mind Research Network. C417 I 650.17 An Assessment of the Social Cognitive Predictors of Exclusive Breastfeeding Behavior Using the Health Action Process Approach. J.L. Martinez-Brockman, F. Shebl, N. Harari, R. Perez-Escamilla. Yale University and Indian Health Service. C418 II 650.18 Lactation Advice Through Texting Can Help (LATCH): An Analysis of Intensity of Engagement via TwoWay Text Messaging. J.L. Martinez-Brockman, N. Harari, R. Perez-Escamilla. Yale University and Indian Health Service. C419 I 650.19 Optimal Time to Initiate Breast Milk Expression in Mothers Delivering Extremely Premature Infants. L. Parker, M. Mueller, S. Sandra, C. Krueger. University of Florida and Medical University of South Carolina. C420 I 650.20 Maternal Weight Over Successive Pregnancies and Breastfeeding Initiation, Duration and Exclusivity. E. Metallinos-Katsaras, E.C. Siu, R. Colchamiro. Simmons College and Massachusetts Department of Public Health. C421 I 650.21 Trends in Breastfeeding in the State of Georgia, 2004–2013. A.K. Anderson, F.A. Kanu, M. Mwaura, T.S. Ward. The University of Georgia. C422 I 650.22 Early-Life Prebiotics Alter Exploratory Behavior, Recognition Memory, and Brain Serotonin in the Neonatal Piglet. S.A. Fleming, S. Monaikul, A.J. Patsavas, B.M. Berg, R.V. Waworuntu, R.N. Dilger. University of Illinois and Mead Johnson Pediatric Nutrition Institute.
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NUTRITION SUNDAY C423 II 650.23 The Impact of Gestational Endocrine Disorders of Breast Milk Fat Characteristics and Infant Growth. L. Ellsworth, E. Harman, C. Anderson, A. Craig, E. John, J. Yeh, B. Gregg. University of Michigan. C424 I 650.24 Antimicrobial Peptides in Human Milk. L. Filgueira, G.K. Kueffer, A. Twigger, M. Walch, D.T. Geddes. University of Fribourg, Switzerland and University of Western Australia, Australia. C425 II 650.25 Serum Concentration of Appetite Regulating Hormones in Infants According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. LarrosaHaro, S. García-Arellano, N. Muñoz-Esparza, E. GuzmánMercado, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C426 I 650.26 Serum Concentration of Appetite Regulating Hormones in Nursing Mothers According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, N. Muñoz-Esparza, E. Guzmán-Mercado, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C427 II 650.27 Comparison of the Serum Concentration of Appetite Regulating Hormones in the Mother-Child Dyad According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, E. Guzmán-Mercado, N. Muñoz-Esparza, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C428 I 650.28 Concentration of Ghrelin and Leptin in Human Serum and Human Milk in Exclusively Breastfeeding Nursing Mothers. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, E. Guzmán-Mercado, N. Muñoz-Esparza, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C429 II 650.29 Evaluation of Three Doses of Dietary Sialyllactose on Growth and Intestinal Development in the Neonatal Piglet. M.H. Monaco, M. Wang, X. Pan, Q. Li, J.D. Richards, M. Chichlowski, B. Berg, R.N. Dilger, S.M. Donovan. University of Illinois and Mead Johnson Pediatric Nutrition Institute. C430 I 650.30 Using Metatranscriptomics to Determine Effects of Dietary Supplementation with Bovine Milk Oligosaccharides in Healthy Adults. S.T. Westreich, D. Barile, J. Salcedo, D.A. Mills, J.T. Smilowitz, I. Korf, D.G. Lemay. University of California, Davis and USDA ARS Western Human Nutrition Research Center. C431 II 650.31 Human Milk Adipokines and Macronutrients and Infant Body Composition in the First Year of Life. D. Geddes, Z. Gridneva, S. Kugananthan, A. Hepworth, L. Ward, W. Tie, C. Lai, P. Hartmann. The University of Western Australia, Australia and The University of Queensland, Australia.
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C432 I 650.32 Maternal Body Mass Index and Presence of Appetite Regulating Hormones and Other Factors in Human Breast Milk. W.A. Clark, M.R. Kwon, E.M. Cress, R.C. Hamdy, H. Cobarrubias, S. Luttrell, W.L. Stone, M. Brannon, J.M. Peterson. East Tennessee State University. C433 I 650.33 Stem-Like Cells in Breastmilk for Hospitalized Preterm Infants. C. Briere, T. Jensen, J.M. McGrath, C. Finck. Connecticut Children’s Medical Center, University of Connecticut and University of Connecticut Health Center. C434 II 650.34 Maternal BMI Is Correlated with NonFasting Human Milk Insulin, but Not Macronutrients. M.L. Sarangam, B. Young, A.L. Garces, L. Figueroa, G. Tejada, J. Kemp, J.L. Westcott, M. Hambidge, N. Krebs. University of Colorado School of Medicine and Institute of Nutrition of Central America and Panama, Guatemala. C435 I 650.35 Protein Intake from Dairy Food Increases Bovine Beta-Casomorphin 7 in Human Mature Milk. J. Flores Alvarado, L. Oropeza Ceja, D. Ronquillo, O. García, G. Martinez, M. Caamaño, C. García Ugalde, M. DuarteVázquez, J. Rosado. Universidad Autonoma de Queretaro, Mexico, Universidad Autonoma de Queret, Mexico, Cindetec and A.C., Mexico. C436 II 650.36 Maternal Factors and Human Milk Oligosaccharide Composition in the CHILD Cohort. B. Robertson, L. Bode, A.K. Sharma, A.B. Becker, P.J. Mandhane, P. Subbarao, S.E. Turvey, D.L. Lefebvre, M.R. Sears, M.B. Azad. University of California San Diego, University of Manitoba, Canada, Children’s Hospital Research Institute of Manitoba, Canada, University of Alberta, Canada, University of Toronto, Canada, University of British Columbia, Canada and McMaster University, Canada. C437 I 650.37 Investigating Methods of Estimating the Rate of Synthesis of Breast Milk and Milk Fat. D.T. Geddes, H. Gardner, C. Lai, P.E. Hartmann, J.C. Kent. The University of Western Australia, Australia. C438 I 650.38 Serum Lipid Profile in Nursing Mothers According to the Type of Feeding: Preliminary Data. E. Romero Velarde, E.M. Vasquez Garibay, A. Larrosa Haro, E. Guzmán Mercado, N.C. Muñoz Esparza, P. Ascencio Esparza. Hospital Civil de Guadalajara, Mexico and Universidad de Guadalajara, Mexico.
SUNDAY NUTRITION
651. FACTORS INFLUENCING LONG-TERM ECONOMIC/ENVIRONMENTAL SUSTAINABILITY OF THE FOOD SUPPLY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C439 I 651.1 A Western Dietary Pattern Has the Highest Environmental Footprints Among Lebanese Adults: Findings from a Cross Sectional Study Among Lebanese Adults. F. Naja, L. Jomaa, L. Itani, J. Zidek, N. Hwalla. American University of Beirut, Lebanon and Beirut Arab University, Lebanon. C440 II 651.2 Environmental Impacts of Typical Dietary Patterns in India. R. Green, E.J. Joy, J. Milner, S.H. Vetter, F. Harris, S. Agrawal, L. Aleksandrowicz, J.I. Macdiarmid, H.G. Jon, P.H. Smith, A. Haines, A.D. Dangour. London School of Hygiene and Tropical Medicine, United Kingdom, University of Aberdeen, United Kingdom and Public Health Foundation of India, India. C441 I 651.3 The Capacity of the Us Food System to Accommodate Improved Diet Quality: Projections to 2030. Z. Conrad, C. Peters, L.K. Johnson, L. Jahns. US Department of Agriculture, Agricultural Research Service, Friedman School of Nutrition Science and Policy and Tufts University. C442 II 651.4 “You Take the Cash Meant for Beans and You Buy Water”: The Multi-Faceted Consequences of Water Insecurity for Pregnant and Postpartum Kenyan Women of Mixed HIV Status. S.M. Collins, J.D. Miller, P. Mbullo, G.O. Boateng, P. Wekesa, M. Onono, S.L. Young. Northwestern University, Cornell University, Maseno University, Kenya and Kenya Medical Research Institute, Kenya. C443 I 651.5 A Meatless Monday Evaluation and Best Practices Guide for Reducing Meat Consumption in Food Service Institutions: A Qualitative Study. M. Chan, R. Ramsing. Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Center for Livable Future and Johns Hopkins Bloomberg School of Public Health. C444 II 651.6 Estimating Nutrient Losses from Wasted Food in the United States Food Supply. M.L. Spiker, H.A. Hiza, S.M. Siddiqi, R.A. Neff. Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Center for a Livable Future and USDA Center for Nutrition Policy and Promotion. C445 I 651.7 Withdrawn. C446 II 651.8 Demographics, Anthropometric Measurements, Vegetable Consumption, and Food Waste of Community Supported Agriculture (CSA) Members in Central Minnesota. E. Heying, K. Butkowski. College of Saint Benedict.
652. PROTEIN METABOLISM, INTAKE AND HEALTH IMPLICATIONS Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C447 I 652.1 Reduced Citrulline Flux and Concentration in Patients with Ketosis-Prone Diabetes Compared to Healthy Controls and Typical Type 2 Diabetes Suggest Impaired Gut Function. J.W. Hsu, S.N. Mulukutla, K.M. Bohren, A. Balasubramanyam, F. Jahoor. USDA/ ARS Children’s Nutrition Research Center, Baylor College of Medicine and Baylor College of Medicine. C448 II 652.2 Sustained Postprandial Muscle Protein Synthesis Rates After Protein Ingestion in Healthy Young Males. N.A. Burd, S. van Vliet, L.J. van Loon, J.W. Beals, S.A. Paluska. University of Illinois at Urbana-Champaign and Maastricht University, Netherlands. C449 I 652.3 Dietary Leucine Supplementation Alters Muscle and Liver Protein Synthesis During Immune System Stimulation in Pigs. M. Rudar, L. Huber, C.L. Zhu, C.F. de Lange. University of Guelph, Canada. C450 II 652.4 Post-Exercise Consumption of Whole Eggs or Egg Whites Improves Whole Body Leucine Balance but Does Not Differentially Modulate Leucine Kinetics in Resistance-Trained Young Men. I.G. Martinez, S. van Vliet, E.L. Shy, J.W. Beals, A.V. Ulanov, M. Orlando, D.W. West, D.R. Moore, S.A. Paluska, N.A. Burd. University of Illinois at Urbana—Champaign and University of Toronto, Canada. C451 I 652.5 Analyzing Short Term Protein Oxidation Provides Evidence About Its Role in Whole Body Protein Metabolism. G. Reckman, M. Priebe, M. Koehorst, T. Boer, R.J. Vonk. UMCG, Netherlands. C452 II 652.6 Lack of Arginase II Spares Arginine and Restores Growth in Mice. J.C. Marini, M.A. Mohammad, I.C. Didelija. Baylor College of Medicine. C453 I 652.7 Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study. J. Marini, U. Agarwal, I.C. Didelija, M.S. Azamian, B. Stoll, S.C. Nagamani. Baylor College of Medicine. C454 II 652.8 Regulation of Leucine-Induced mTORC1 Activation in Skeletal Muscle of Neonatal Pigs. A. Suryawan, H.V. Nguyen, R.D. Parada, T.A. Davis. USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics and Baylor College of Medicine. C455 I 652.9 The Potential of Leucine to Regulate Skeletal Muscle Energy Metabolism Under Obesogenic Conditions. J.I. Baum, T.G. Inman, S.A. Shouse. University of Arkansas.
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NUTRITION SUNDAY C456 II 652.10 Whole Body Net Protein Balance Plateaus in Response to Varying Protein Intakes During PostExercise Recovery: Identification of a Maximal Anabolic Intake. M. Mazzulla, H. Kato, J. Packer, D. Wooding, D. Moore. University of Toronto, Canada, Ajinomoto Co. and Inc., Japan. C457 I 652.11 Variable Intensity Exercise Increases Protein Requirements in Active Male and Female Adolescents as Determined by the Indicator Amino Acid Oxidation (IAAO) Technique. J.C. Brooks, K.A. Volterman, D.W. West, G. Courtney-Martin, P.B. Pencharz, D.R. Moore. University of Toronto, Canada and The Hospital for Sick Children, Canada. C458 II 652.12 ncrease in FGF21 Stimulates Browning Markers in White Adipose Tissue in Rats Fed a Low Protein High Carbohydrate Diet During Acute Cold Exposure. G. Alemán, A. Vigil-Martínez, A.L. Castro, I. Flores-Galicia, I. Torre-Villalvazo, A. Díaz-Villaseñor, L.A. VelázquezVillegas, L.G. Noriega, P. López-Romero, D.C. GonzálezHirschfeld, G. Ordaz, O. Granados, N. Torres, A.R. Tovar. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Instituto de Investigaciones Biomédicas and UNAM, Mexico. C459 I 652.13 Dietary Protein Sources Beyond Proteins and Amino Acids—A Comparative Study of the Small Molecular Weight Components of Meat and Fish Using Metabolomics. A. Ross, A. Vincent, O.I. Savolainen, A. Sandberg, I. Undeland. Chalmers University of Technology, Sweden. C460 II 652.14 Crosstalk Between Lactobacillus reuteri and Mammalian Intestinal Epithelium. B.P. Gsnesh, A. Hall, S. Ayyaswamy, R. Fultz, J. Versalovic. Baylor College of Medicine. C461 I 652.15 Sex Differences in Snack Food Reinforcement in Response to Increasing Dietary Protein. S.L. Casperson, L. Johnson, J.N. Roemmich. USDA/ARS. C462 II 652.16 Lengths of Stunted Children Are Severely Compromised, but Breadths—Not So Much: Disproportions in the Anthropometric Deficits in So-Called “Chronic Malnutrition”. K. Shiu, N.W. Solomons, W.M. Liem, R. García-Meza. CeSSIAM, Guatemala. C463 I 652.17 Habitual Use of Flavored Commercial Products for Thin Gruel Beverage Preparation and the Acceptability of Their Fortification with Whey Protein Concentration Among Low-Income Women in the Central Highlands of Guatemala. A. Platte, M. Vossenaar, A. Zamora, C.L. Arriaga, N.W. Solomons, D. Hirst, M.J. Bonorden. CeSSIAM, Guatemala and Hormel Foods Company. C464 II 652.18 Effects of Consuming Different Protein Preloads on Appetite, Satiety, and Subsequent Food Intake. S.M. Douglas, J.A. Gwin, H.J. Leidy. Purdue University. C465 I 652.19 Body Fat Changes in the Beef WISE Study: Beef’s Role in Weight Improvement, Satisfaction, and Energy. R.D. Sayer, K.J. Speaker, Z. Pan, J.C. Peters, H.J. Wyatt, J.O. Hill. University of Colorado Anschutz Medical Campus.
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C466 II 652.20 Whey Protein Protects Muscle Mass Loss of Older Adults During 7 Days of Inactivity and Accelerates Recovery of Aerobic Fitness During Rehabilitation. E.J. Arentson-Lantz, E. Galvan, A. Wacher, D. Paddon-Jones. University of Texas Medical Branch. C467 I 652.21 Animal and Plant Proteins Impact Risk of Type 2 Diabetes Mellitus in the Framingham Study. L. Lara Castor, M. Bradlee, M.R. Singer, L.L. Moore. Boston University.
653. LIPID AND FATTY ACID METABOLISM AND TRANSPORT Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C468 I 653.1 Differences in the Enterocyte Cytoplasmic Lipid Droplet Proteome in Mice Resistant (Acyl CoA: Diacylglycerol Acyltransferase 1 Deficient) Versus Susceptible to Diet-Induced Obesity. A. Carreiro, K.K. Buhman. Purdue University. C469 II 653.2 Effects of Medium Chain Fatty Acid on the Expression of the Genes Related with Glycolytic and Fatty Acid Synthetic Pathways in the Mice Refed After Starvation. S. Takami, K. Matsumoto, K. Honma, K. Mochizuki, T. Goda. University of Shizuoka, Japan and University of Yamanashi, Japan. C470 I 653.3 cAMP-Dependent and Independent Mitigation of mTORC1-Driven Lipogenesis by Short-Chain Fatty Acids, R-α-Lipoic Acid and 4-Phenylbutyric Acid. R. Moreau, B. He. University of Nebraska—Lincoln. C471 II 653.4 The Role of FADS1 and FADS2 Genes in Oleic Acid (18:1n-9) Metabolism: FADS1 Δ7-Desaturates Gondoic Acid (20:1n-9, 11-20:1) to 7,11-20:2. H. Park, M.G. Engel, K. Vogt-Lowell, P. Lawrence, K. Kothapalli, J.T. Brenna. Cornell University. C472 I 653.5 A Need to Analyze Radiolabeled Cholesteryl Ethers for Biological Stability Before Use. D. Kollareth Manual, I.H. Hansen, R.J. Deckelbaum. College of Physicians and Surgeons and Columbia University Medical Center. C473 II 653.6 Short Term Fast Food and Mediterranean Diet Are Able to Change the HDL Lipidome with Different Patterns. C. Zhu, L. Sawrey-Kubicek, E. Beals, R.L. Hughes, C.H. Rhodes, R. Sacchi, A.M. Zivkovic. University of California Davis.
SUNDAY NUTRITION C474 I 653.7 Locating Apolipoprotein A2 Protein in the Central Nervous System. S. Azzam, J. Gamble, M. Decker, X. Li, Y. Hernandez, K.P. Strohl. Case Western Reserve University and Louis Stokes Cleveland VA Medical Center. C475 II 653.8 Branched Chain Fatty Acids Content of Natto. D. Wang, Y. Yang, P. Lawrence, J. Brenna. Cornell University. C476 I 653.9 How Does DHA Reach the Brain to Provide Neuroprotection After Hypoxic-Ischemic Injury? D. Kollareth Manual, H. Zirpoli, V. Ten, R.J. Deckelbaum. College of Physicians and Surgeons and Columbia University Medical Center. C477 II 653.10 Effects of Dietary Anaplerotic Carbon Sources and Ketogenic Fatty Acids on Hepatic Fatty Acid Oxidation in Neonatal Pigs. J. Zhao, B. Pike, Y. Zhang, S. Sabin, A. Smith, Y. Zhu, J. Odle, L. Xi. NCSU. C478 I 653.11 HDL-Associated Proteins and LDL Differentially Modulate Chronic Myelogenous Leukemia Cell Viability. C.J. Andersen, K. Murray, N. Ragonesi, A. Doerr, L. Cintron-Rivera, L. Dupree. Fairfield University.
654. ENERGY AND MACRONUTRIENT METABOLISM AND THE GUT Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C479 I 654.1 Neonatal Diet Composition Modulates Ileum Mitochondrial Function in a Neonatal Pig Model. E. Carvalho, A.R. Moreira, A.K. Bowlin, M.K. Saraf, S.H. Adams, E. Borsheim, L. Yeruva. Center for Neurosciences and Cell Biology, University of Coimbra, Portugal, Arkansas Children’s Nutrition Center, UAMS and Arkansas Children’s Research Institute. C480 II 654.2 Stimulation to the Oral Cavity Increase Splanchnic Circulation and Diet-Induced Thermogenesis After Drink Intake. Y. Hamada, N. Hayashi. Tokyo Institute of Technology, Japan. C481 I 654.3 Gut Microbiota Increased by Omega-3 Fatty Acids Is Negatively Correlated with Hepatic Lipid Metabolism-Associated Genes in Mice with High Carbohydrate Diet-Induced Steatosi. K. Huang, R.G. Nichols, A. Sebastian, I. Albert, A.D. Patterson, A. Ross. The Pennsylvania State University. C482 II 654.4 Effect of Medium Chain Triglycerides on TCA and Ketogenic Capacity of Proximal Intestinal Fatty Acid Oxidation in Clofibrate Feed Newborn Pigs. B.E. Pike, J. Zhao, J. Hicks, Y. Zhang, A. Smith, H. Liu, J. Odle, L. Xi. NCSU. C483 I 654.5 Dietary Fiber’s Contribution to the Energy Needs of the Microbiota. D.T. Gordon, D.J. Baer, V. Mai. NDSU, ARS, USDA and University of Florida.
655. METABOLIC PHENOTYPING, METABOLOMICS AND BIOMARKERS Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C484 I 655.1 Plasma Metabolome, PON1 Status, Environmental Exposures and Childhood Autism. J. Sotelo, I. Hertz-Picciotto, C. Slupsky. University of California at Davis. C485 II 655.2 Glycovariations in Key HDL-Associated Glycoproteins Differentiate Between Clinical Groups and Affect the Immunomodulatory Capacity of HDL. A.M. Zivkovic, S. Krishnan, M. Shimoda, R. Sacchi, J.K. Muchena, G. Luxardi, G.A. Kaysen, A.N. Parikh, V. Ngassam, K. Johansen, G. Chertow, B. Grimes, J.T. Smilowitz, E. Maverakis, C.B. Lebrilla. UC Davis, UC San Francisco and Stanford University. C486 I 655.3 Metabolism of Beta-Alanine in Rat Liver: Degradation to Acetyl-CoA and Carboxylation to 2-(Aminomethyl)-Malonate. K. Wilson, J. Hess, G. Zhang, H. Brunengraber, G. Tochtrop. Case Western Reserve University and Duke University. C487 II 655.4 Biomarkers of Food Intake and Nutrient Status Are Associated with Glucose Tolerance Status and Development of Type 2 Diabetes. O. Savolainen, M. Vendelbo Lind, G. Bergström, B. Fagerberg, A. Sandberg, A. Ross. Chalmers University of Technology, Sweden, University of Copenhagen, Denmark and Sahlgrenska Academy, Sweden. C488 I 655.5 Untargeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism in β, β-Carotene-9′, 10′-Oxygenase 2 Knockout Mice. Y. Lyu, L. Wu, X. Guo, A. Davis, S. Clarke, E. Lucas, B. Smith, W. Wang, D.M. Medeiros, X. Shen, D. Lin. Nanjing University of Finance and Economics, People’s Republic of China, Oklahoma State University, Kansas State University and University of MissouriKansas City. C489 II 655.6 Lipidomic Profiling of Erythocytes in Septic Patients Revels Novel Biomarkers. G.C. Mecatti, M.F. Messias, C.F. Angolini, P.O. de Oliveira Carvalho. Sao Francisco University, Brazil and University of Campinas, Brazil. C490 I 655.7 Metabolic Pathway Analysis of Biochanin A Administration on Obesity-Induced Metabolic Dysfunction. M. Hong, H. Park, S. Kim, N. Jeong, M. Kim. Korea Food Research Institute, Republic of Korea, and Korea University of Science and Technology, Republic of Korea. C491 II 655.8 Urinary Enterolignan-Associated Changes in Plasma Metabolites. F. Miles, S. Navarro, Y. Schwarz, T. Randolph, M. Neuhouser, A. Shojaie, H. Gu, D. Djukovic, M. Kratz, M. Hullar, P. Lampe, D. Raftery, J. Lampe. Fred Hutchinson Cancer Research Center, University of Washington, University of Washington and Northwest Metabolomics Research Center.
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PATHOLOGY SUNDAY
Pathology 656. RESPIRATORY PATHOPHYSIOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Pulmonary Pathobiology Presentation time: 11:45 am–1:45 pm A1 656.1 Abrogation of RAGE Signaling Using SemiSynthetic Glycosaminoglycan Ethers (SAGEs) Ameliorates Inflammation in Mice Exposed to Secondhand Tobacco Smoke. K.M. Hirschi, J.B. Lewis, P.D. Hall, T.J. Wright, K.M. Egbert, K.C. Ogden, S.M. Nelson, J.C. Clark, D.C. Milner, J.A. Arroyo, P.R. Reynolds. Brigham Young University. A2 656.2 Phospholipase D Regulates GSK3β mediated Epithelial to Mesenchymal Transition and Akt Mediated Cell Death Leading to Pulmonary Fibrosis. V. Suryadevara, T.J. Royston, V. Natarajan. University of Illinois. A3 656.3 Non-Pungent Long Chain Capsaicin-Analogs Arvanil and Olvanil Display Better Anti-Invasive Activity Than Capsaicin in Human Small Cell Lung Cancers. K.W. Colclough, J. Seidler, A.T. Akers, J.D. Hurley, K.C. Brown, N.A. Nolan, P. Dasgupta. Marshall University, Joan C. Edwards School of Medicine and Marshall University. A4 656.4 Disease Specific Signatures Identified by RNA-Seq of Sorted Lung Cellular Populations. P.A. Reyfman, L. Morales-Nebreda, J.M. Walter, A. McQuattie-Pimentel, C. Chen, K.R. Anekalla, H. Abdala-Valencia, T.J. Yacoub, M. Antalek, M. Chi, S.F. Chiu, F. Gonzalez, P.J. Homan, S. Soberanes, A. Bharat, M.M. DeCamp, S.M. Bhorade, E.T. Bartom, R.I. Morimoto, W. Balch, J.I. Sznajder, N.S. Chandel, K.M. Ridge, N. Bagheri, L.A. Amaral, G. Budinger, H. Perlman, D. Winter, A.V. Misharin. Northwestern University and Scripps Research Institute. A5 656.5 Loss of Function Mutation in TIMP2 Gene Accelerates Tumorigenesis and Mortality in Murine Model of Lung Cancer Through EGFR Signaling. S. Kumar, S. Jensen, D. Peeney, A. Chowdhury, B. Wei, W.G. StetlerStevenson. NCI/NIH. A6 656.6 Whole Slide Quantitative Image Analysis Can Demonstrate Bleomycin Induced Dose-Dependent Increases in Fibrotic Areas Within Histologically Stained Rat Lung Tissue. A. Young, M. McElroy, S. Naylor, M. Anderson, A. Bigley, K. McGregor, L. Sherry. In Vivo Discovery, Charles River, United Kingdom, and OracleBio, United Kingdom. A7 656.7 The Role of Serine Protease in Diaphragm Development. Y. Hsu, S. Yang, C. Hung, C. Hung, H. Huang, I. Yu, S. Lin. Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taiwan, Liver Disease Prevention and Treatment Research Foundation, Taiwan, Graduate Institute of Medical Genomic and Proteomics, College of Medicine, National Taiwan University, Taiwan, Laboratory Animal Center, College of Medicine, National Taiwan University, Taiwan, Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taiwan, Center for Genomic Medicine and National Taiwan University, Taiwan.
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A8 656.8 Lysophosphatidic Acid Stimulation of Amphiregulin Shedding Enhanced Paracrine Role of BM CD11+ Cells. T. Liu, F. Gonzalez De Los Santos, Z. Wu, S.H. Phan. Univerisity of Michigan. A9 656.9 Sex Dependent Role of Activating Transcription Factor 3 (ATF3) Expression in Modulating the Asthmatic Phenotype in an Acute Mouse Model of Airway Neutrophilia. A. Spinelli, N. Fuentes Ortiz, M. Nicoleau, U. Sinha, C.R. Caruso, S. DiAngelo, Z. Chroneos, P. Silveyra. Penn State College of Medicine and MS Hershey Medical Center. A10 656.10 Effect of Seasonal Alterations of Air Quality Including Asian Sand Dust on Health-Related Quality of Life and Respiratory Symptoms in Korea. Y. Ishihara, M. Nakao, C. Kim, I. Hyun. Kurume University, Japan, Hallym University Dongtan Sacred Heart Hospital, Republic of Korea. A11 656.11 Resolution of Right Ventricular Fibrosis by a Cancer Chemotherapeutic Agent: A Novel Therapy to Treat Pulmonary Arterial Hypertension. V. Rybka, N.V. Shults, Y.F. Ibrahim, Y. Suzuki. Georgetown University and Minia University, Egypt. A12 656.12 Effect of Aliskiren, a Direct Renin Inhibitor, on Macrophage Accumulation in a Rat Model of Pulmonary Fibrosis Induced by Fat Embolism. A. Siddiqi, A. Syed, A. Yembur, D. Arif, R. Ponnapureddy, K. Tappeta, A. Fletcher, C. Patel, S. Hamidpour, A. Poisner, A. Molteni. University of Missouri-Kansas City Medical School, University of Kansas Medical Center. A13 656.13 Effect and Regulatory Mechanisms of LowDensity Lipoprotein on the Growth and Migration of A549 Human Lung Cancer Cells. S. Tsao. Taipei Medical University, Taiwan. A14 656.14 Heparanase Contributes to Idiopathic Pulmonary Fibrosis via Regulation of A20/TNFAIP Expression. Y. Yang, A. Lara, A. Rutebemberwa, E. Schmidt. University of Colorado Denver. A15 656.15 A Role of IL-21 in Pulmonary Fibroblast Activation. R. Sathiaseelan, C. Huang, L.K. Senavirathna, L. Liu. Oklahoma State University. A16 656.16 Effect of Losartan on 2 Types of Macrophages in a Chronic Rat Model of Fat Embolism. D. Arif, F. Khalafi, A. Siddiqi, S. Philips, A. Said, R. Ponnapureddy, K. Tappeta, A. Poisner, S. Hamidpour, A. Molteni. University of MissouriKansas City, University of Kansas Medical Center. A17 656.17 Capsaicin Synergizes with Camptothecin to Show Enhanced Apoptotic Activity in Small Cell Lung Cancer. J.R. Friedman, H.E. Perry, K.C. Brown, A.T. Akers, N.A. Nolan, W.D. Rollyson, Y.C. Chen, K.L. Denning, L.G. Brown, P. Dasgupta. Joan C. Edwards School of Medicine, Marshall University and Alderson Broaddus University. A18 656.18 The Assessment of Clinically Relevant Extracellular Matrix Markers in a Bleomycin-Induced Mouse Model of Lung Fibrosis. A. Young, P. Nath, D. Leeming, M. Karsdal, S. Brockbank, D. Rider, S. Cruwys. Discovery, Charles River, United Kingdom, Nordic Biosciences, Denmark and Grunenthal, Germany.
SUNDAY PATHOLOGY A19 656.19 Patient and Healthcare System Delay in Pulmonary Tuberculosis Patients, Tabriz, Iran 2012–2014. M.E. Kalan, H.Y. Sis, V. Kelkar, S.H. Harrison, J. Han. North Carolina Agricultral and Technical State University and Tuberculosis and Lung Disease Research Center, Iran. A20 656.20 Detection of Phenotypic Differences in Alveolar Macrophages Using Ionized Calcium-Binding Adapter Molecule 1 Marker. D.K. Meyerholz, C.M. Hogan, R.M. Glanz, J.A. Goeken, M.R. Leidinger, G.K. Ofori-Amanfo, L. McQuillen, K.M. Donovan, S.C. Harwani, H.A. Flaherty. University of Iowa Carver College of Medicine, University of Southern California and Iowa State University. A21 656.21 Influenza a Infection Decrease the Population of Tissue Resident Alveolar Macrophages. F. GonzalezGonzalez, A. McQuattie-Pimentel, S. Soberanes, M. Casalino-Matsuda, M. Chi, R. Piseaux, P. Sporn, S. Budinger. Northwestern University. A22 656.22 Developing an in Vivo Model of Reinke’s Edema. A. Durkes, P. Sivasankar. Purdue University.
657. IMMUNE RESPONSES IN PATHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Immunopathology Inflammation Presentation time: 11:45 am–1:45 pm A23 657.1 Activity Transcription Factor 3 Suppressed LPS-Induced Adipocyte Inflammation in Experimental Sepsis. Y. Wang, C. Cheng, P. Lai. National Chung Hsing University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Buddhist Tzu Chi General Hospital, Taiwan. A24 657.2 ATF3 Protects LPS-Induced Acute Pancreatic Inflammation via Modulating NFκB-Mediated iNOS Production in Mice. Y. Chen, Y. Tseng, C. Liu, H. Lin, C. Cheng, P. Lai. Tzu Chi University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Taipei Medical University, Taiwan. A25 657.3 Inflammasome Inhibition in Influenza A Virus Infected Juvenile Mice Leads to Improved Survival and Outcomes. N. Ravindran, C.M. Koch, K.M. Ridge, B.M. Coates. Northwestern University. A26 657.4 Pro-Inflammatory and Anti-Inflammatory Cytokine Expression in Tnf -/- and WT Mice with Chronic Colitis. T.M. Smith, A. Kozik, C.H. Nakatsu, Y.L. Jones-Hall. Purdue University. A27 657.5 The Role of Scleraxis in Intestinal Fibroblasts. C. Johnson, A. Nillas, T.A. Reaves. Medical University of SC. A28 657.6 Involvement of RAGE Signaling and Inflammatory Cytokine Elaboration Following in Vitro Exposure to Electronic Cigarette Liquid. K.M. Hirschi, J.B. Lewis, A.S. Ostergar, P.D. Hall, D.S. Broberg, J.A. Arroyo, P.R. Reynolds. Brigham Young University. A29 657.7 The Effect of Plumbagin on Proinflammatory Cytokines Expression in LPS-Activated BV-2 Microglia Cells. S.S. Messeha, N.O. Zarmouh, M.G. Kolta, K.F. Soliman. Florida A&M University.
A30 657.8 Comparative Analysis of Inflammatory Cytokines and Growth Factors in Young and Old Aged Normal Individuals. S. Rodrigues, A. Walborn, D. Hoppensteadt, J. Fareed, M. Rondina. Loyola University Chicago and University of Utah. A31 657.9 Tissue-Specific Expression Patterns of Tau and Ubiquitin Proteins Coordinated with Yersinia pestis Pathogenesis in a Non-Human Primate Model. C. Moyler, N. Chakraborty, A. Gautam, R. Hammamieh, M. Jett. The Geneva Foundation and U.S. Army Center for Environmental Health Research. A32 657.10 Identifying Key Domains in Endothelial IQGAP1 Critical for Leukocyte Transmigration. P. Dalal, D. Sullivan, W. Muller. Northwestern University. A33 657.11 Immunoproteomic Identification of Bovine Pericardial Heart Valve Antigens. K.Y. Gates, A. Dalgliesh, L. Griffiths. Mayo Clinic. A34 657.12 Sex, Age, and TNF Influence the Gut Microbiota in a Mouse Model of TNBS Colitis. A.J. Kozik. Purdue University. A35 657.13 Effect of Probiotic Pediococcus pentosaceus on Intestinal Permeability and Occludin Protein Distribution in a Murine Model of Colitis. L. Torres-Aguilar, L. RodriguezFragoso, F. Garcia-Vazquez, J. Reyes-Esparza. Universidad Autonoma del Estado de Morelos, Mexico and Instituto Nacional de Pediatria, Mexico. A36 657.14 Increased Urinary IL-6 and Mucosal COX-2 Expression in Patients with Idiopathic Detrusor Overactivity. H. Liu, H. Kuo. Tzu Chi Hospitial, Taiwan. A37 657.15 Inflammation Response of Phage-Based Films on Titanium Surface in Vitro. Y. Sun, B. Feng. Southwest Jiaotong University, People’s Republic of China. A38 657.16 PAD4 Deficiency Limits Kidney Dysregulation in a Murine Model of Shock/Sepsis. B. Biron Girard, Y. Chen, C. Chung, J.B. Reichner, A. Ayala. Brown University/Rhode Island Hospital and Rhode Island Hospital. A39 657.17 A Study Protocol for the Comparative Study of Biological and Metabolism Bio-Marker Between Healthy Population and Patients with Acne Vulgaris. K. Kim, I. Ha, E. Kim. College of Korean Medicine, Kyung Hee University, Republic of Korea, Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, Republic of Korea. A40 657.18 Gas6 Reduces Cellular Respiration and Increases Reactive Oxygen Species in Immortalized Human First Trimester Trophoblast Cells. C.A. Mejia, M.B. Appiah, J.B. Lewis, B.T. Bikman, J.M. Hansen, P.R. Reynolds, J.A. Arroyo. Brigham Young University. A41 657.19 Profiling of Inflammatory Biomarkers in Synovial Fluid from Patients Undergoing Primary Total Joint Arthroplasty. E. Finkler, C. Wanderling, C. Thorson, K. Galicia, S. Statz, J. Fareed, W. Hopkinson. Loyola University ChicagoSSOM. A42 657.20 Splenic Natural Killer Cell Phenotypes Are Heritable and Correlate with Lifespan. S.A. Bumgardner, Y. Zhou, Z. Jiang, E.J. Coe, R. Pazdro. University of Georgia. A43 657.21 Silica-Triggered Multi-Organ Autoimmune Gene Expression in Lupus-Prone Mice Is Ablated by Docosahexaenoic Acid Consumption. M.A. Bates, K.N. Gilley, D.N. Jackson-Humbles, J.R. Harkema, A. Holian, J.J. Pestka. Michigan State University and University of Montana. A44 469.1 A Novel Murine Model of Primary Sclerosing Cholangitis Associated Inflammatory Bowel Disease. K.D. Battista, C.T. Shearn, E.E. Alexeev, L.E. Glover, D.R. Petersen, S.P. Colgan, B.P. Fennimore. University of Colorado.
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658. PATHOBIOLOGY OF INFECTIOUS DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Inflammation Immunopathology Presentation time: 11:45 am–1:45 pm A48 184.6 Production of TLRs Triggered Pro-Inflammatory Cytokines Through Calcium Dependent and Independent Pathways in HaCaT Cells. E. Kim, I. Ha, K. Kim. Kyunghee University Korean Medicine Hospital, Republic of Korea, College of Korean Medicine, Kyunghee University, Republic of Korea. A49 658.1 West-Nile Virus Replicon Particles Infect 293T Cells Expressing Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin Related. N. Leonard, N. Crowson, A. Madigan, M. Schmitz, E. Alcala, O. Martinez. Winona State University. A50 658.2 Addition of Retinoic Acid-Inducible Gene 1 to Enhance Ebola Virus-Like Particle Vaccine. E.O. Oredola, E. Pottebaum, M. Zell, O. Martinez. Winona State University. A51 658.3 Investigating the Potential Role of North American Animals as Hosts for Zika Virus. I. Ragan, E. Blizzard, R. Bowen. Kansas State University and Colorado State University. A52 658.4 Evaluation of Fluorescence Microsphere Immunoassay for Antibody Detection to Rift Valley Fever Nucleocapsid Protein and Glycoproteins. I. Ragan, B. Faburay, D.S. McVey, J.A. Richt, A.S. Davis, R.R. Rowland, W.C. Wilson. Kansas State University and USDA ARS. A53 658.5 Reverse Transcriptase Real Time PCR Detection of Rift Valley Fever Virus RNA in Formalin-Fixed, Paraffin-Embedded Tissues. D. Upreti, W.C. Wilson, J.A. Richt, A.S. Davis, J.D. Trujillo. Kansas State University, USDA and ARS. A54 658.6 Co-Infection with Giardia duodenalis Protects the Host Against Enteropathogenic Escherichia coli via NLRP3 Inflammasome-Dependent Anti-Microbial Peptide Production. A. Manko, J. Motta, J. Cotton, A. Oyeyemi, B. Vallance, P. Beck, J. Wallace, A. Buret. University of Calgary, Canada and University of British Columbia, Canada. A55 658.7 Effects of Acute Sepsis on Renal Structure and Sympathetic Innervation in Mice. T. Alkhateeb, T.R. Ozment, G.A. Youngberg, M.E. Howell, C.A. Stuart, J.B. Price, T.C. Jones, D.L. Williams, T.E. Blair, D.B. Hoover. East Tennessee State University. A56 658.8 Gelsolin, but Not Mucin, Inhibits P. aeruginosa Swimming Motility in Vitro. A.B. Husak, S.A. Busch, J. Robarge, J.L. Bankers-Fulbright. Augsburg College.
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A57 658.9 Method Development for the Micromolar Analysis of Pyocyanin (PYO) in Blood and Urine via Mass Spectrometry (MS). T.P. Mawhinney, D.L. Chance, J.K. Waters, V.V. Mossine. University of Missouri. A58 658.10 RGDSK Peptide Functionalized Helical Rosette Nanotubes (RGDSK-HRNs) Block Integrin αvβ3 and inhibit E. coli Adherence to Intestinal Porcine Epithelial 1 Cell Line (IPEC1) in Vitro. N. Le, C. Quach, G. Aulakh, V. Gerdts, H. Fenniri, B. Singh. Western College of Veterinary Medicine, University of Saskatchewan, Canada, Vaccine and Infectious Disease Organization—International Vaccine Centre (VIDO—InterVac), Canada, Northeastern University, Faculty of Veterinary Medicine and University of Calgary, Canada. A59 658.11 Development of an in Vitro Bladder Epithelial Cell Culture System. S. Kim. Washington University in St Louis. A60 658.12 Model Systems to Study the Pathogenesis of Zika Virus-Mediated Eye Disease. L.E. Martinez, D. Contreras, M.K. Jones, V. Gangalapudi, J. Tang, S. Wang, V. Arumugaswami. Cedars-Sinai Medical Center. A61 658.13 Transcriptomic and Proteomic Analysis to Delineate the Mechanism of Antibiofilm Activity of 3-Furancarboxaldehyde on Group A Streptococcus. S. Karutha Pandian, G. Ashwinkumar Subramenium. Alagappa University, India. A62 658.14 Inhibition of Biofilm and Virulence of Candida albicans by a Marine Bacterial Isolate from Palk Bay. G. Ashwinkumar Subramenium, T.K. Swetha, S. Karutha Pandian. Alagappa University, India.
659. NEUROPATHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Neuropathology Presentation time: 11:45 am–1:45 pm A63 659.1 Floating Microelectrode Arrays Chronically Implanted Into the Feline Peripheral Nerve Elicit a Characteristic Tissue Response. C.L. Kolarcik, K. Puglisi, A. Lesniak, A.J. Demetris, L.E. Fisher, R.A. Gaunt. University of Pittsburgh. A64 659.2 Cyclin A2 Loss Impairs Hippocampal Development. M. Goksel, P. Gygli, J. Chang, B. Goksel, H.N. Gokozan, R. Nelson, C. Czeisler, J.J. Otero. The Ohio State University. A65 659.3 Visualization of Neuronal Connectivity in NPARM PHOX2b Mutants with a Modified PACT Protocol. S.R. Fair. The Ohio State University. A66 659.4 1,2,3,4,6 Penta-O-Galloyl-β-D-Glucose Attenuates LPS/IFNγ-Induced MCP-5 and Pro-MMP-9 Cytokines Release in BV-2 Microglia Cells by Inhibiting NFκB and MAPK signaling Proteins. P.F. Mendonca, E.F. Taka, D.F. Bauer, K.F. Soliman. Florida A&M University.
SUNDAY PATHOLOGY A67 659.5 Naturally, Occurring Neurotrophic Factor from Mu Bie Zi (Momordica cochinchinensis) Seeds. E.A. Mazzio, B. Georges, K.F. Soliman. Florida A&M University. A68 659.6 Alzheimer’s Disease: Prevention, Symptoms and Treatment. L. DiCarlo, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. A69 659.7 Ablation of Mitochondria Fusion Protein Mfn2 Causes an Oxidative Stress Response and Eventual Neuronal Death in the Hippocampus and Cortex. S. Jiang, X. Wang, P. Nandy, C. Wang, S. Torres, S.L. Siedlak, X. Zhu. Case Western Reserve University. A70 659.8 Caffeine May Affect Apoptosis and Autophagy Activity to Promote Dopaminergic Cells Survival Under the Rotenone Induced Parkinson Disease Model. C. Luo,Y. Huang, B. Huang, T. Lu, Y. Fu. Department of Biomedical Science and Environmental Biology, Kaohsiung Medial University, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Taiwan, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Department of Biomedical Science and Environmental Biology, Center for Infectious Disease and Cancer Research and Kaohsiung Medical University, Taiwan. A71 659.9 Investigating the Underlying Mechanisms of Chemosensory Dysfunctions in Alzheimer’s Disease Using Caenorhabditis elegans with Mutations in Presenilin 1. M. Parvand, T. Bozorgmehr, C. Rankin. University of British Columbia, Canada. A72 659.10 Aberrant Histone Turnover in Alzheimer’s Disease. J.A. Dowell, M.A. Gitcho, J.M. Denu. Wisconsin Institutes for Discovery, Delaware State University and University of Wisconsin. A73 659.11 The Effect of Cardiolipin on Microglial Activation and Microglia-Mediated Neuronal Death. C. Pointer, A. Klegeris. University of British Columbia Okanagan, Canada. A74 659.12 High Fat Diet Increases Cognitive Decline and Neuroinflammation in a Model of Orexin Loss. C.M. Duffy, J.P. Nixon, T.A. Butterick. Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota’s Discovery, Research, and Innovation Economy, Brain Conditions and Minnesota Obesity Center. A75 659.13 Innate Immunity and Alzheimer’s Disease. A. Affaneh, M. Lahey, Z. Langston, E. Cudaback. DePaul University. A76 659.14 APOE Genotype-Dependent Differential Influences on MS. M. Lahey, Z. Langston, A. Affaneh, E. Cudaback. DePaul University.
A77 659.15 APOE Genotype Influences Glial Activity in MS. Z. Langston, M. Lahey, A. Affaneh, E. Cudaback. DePaul University. A78 659.16 Better Targeting, Better Efficiency of AdenoAssociated Virus Gene Transfer in the Central Nervous System for Expression of Retromer Proteins. D.D. Porter, K.L. Jackson, R.D. Dayton, R.L. Klein. King University, LSU Health Shreveport and LSU Health Science—Shreveport. A79 659.17 Surface Area May Be a More Useful Risk Factor for Cerebral Aneurysm Rupture Than Maximum Diameter. S. Fukuda, Y. Shimogona. Kyoto Medical Center, Japan and Tohoku University, Japan. A80 659.18 Inhibition of Stroke-Induced Injury by Phlebotomy. Y. Tsai, H. Liou, S. Tang, H. Liou, J. Jeng, W. Fu. Institute of Pharmacology, College of Medicine, National Taiwan University, Taiwan, Department of Neurology and National Taiwan University Hospital, Taiwan. A81 659.19 Pathological Role of Two Chemokines RANTES and MIF in Ischemic Stroke. Y. Liu, S. Tang, Liou, H. Tu, K. Kang, H. Liou, J. Jeng, W. Fu. National Taiwan University, Taiwan and National Taiwan University Hospital, Taiwan. A82 659.20 Modeling the Ischemic Neurovascular Unit in a Dish Using Patient-Specific Induced Pluripotent Stem Cells. S. Page. TTUHSC. A83 659.21 Animating External Magnetic Guidance of Intrathecally Delivered Gold-Coated Nanoparticles to Treat Intramedullary Spinal Tumors. A. Orland, K. Brennan, L. Lebowicz, C. Wellman, A. Mehta. University of Illinois at Chicago. A84 659.22 Evaluation of Immunohistochemical Markers for Application in a Novel Neurofibromatosis-1 Porcine Model. D.K. Meyerholz, G.K. Ofori-Amanfo, M.R. Leidinger, D. Quelle, B. Darbro, K. Panzer, J.C. Sieren, R. Khanna, C. Rogers, K. White, J. Weimer. University of Iowa Carver College of Medicine, University of Iowa, University of Arizona, Exemplar Genetics, Sanford Research and University of South Dakota. A85 659.23 Regulator of G-Protein Signaling 6 (RGS6) Expression in Human Substantia Nigra Pars Compacta (SNc) and Loss in Parkinson’s Disease (PD). Z. Luo, K.E. Ahlers, J. Yang, B. Chakravarti, H.E. Stevens, N.S. Narayanan, R.A. Fisher. The University of Iowa.
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Pharmacology 660. PHARMACOLOGY EDUCATION I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Pharmacology Education Presentation time: 12:30 pm–2:30 pm D1 660.1 A Team-Based Assignment to Integrate Basic Science and Pharmacotherapeutic Principles for Anticancer Agents. P. Jungsuwadee, P. Sakharkar, S. Kurup. School of Pharmacy, Fairleigh Dickinson University, and College of Pharmacy, Roosevelt University. D2 660.2 Promoting the Active Learning of Pharmacology and Clinical Therapeutics Utilizing Team-Based Learning (TBL) Methods in Second Year Systems Modules. L. Gorman. UCF College of Medicine. D3 660.3 The Use of Patient-Oriented-Problem-Solving (POPS) in Pharmacology Exercises to Develop Simulated Scenes for Application During TBL. M.J. Hernandez, S.J. Foldy, F.J. Abene, T.J. Lindsey, J. Giannini. Alabama College of Ostepathic Medicine. D4 660.4 Tools Enhance Learning of Medical Pharmacology. Q. Zhong. St Matthews University School of Medicine, Cayman Islands. D5 660.5 Hands-on Modeling/Simulation Using MATLAB and SimBiology Improves Student Learning in Graduate Pharmacology and Pharmaceutical Sciences Education. J. Chang, H.H. Alsulimani, M. Han, Q. Ye, F. Buyukozturk, J. Kim. Northeastern University, The MathWorks and Inc. D6 660.6 A Process-Oriented Guided Inquiry Approach to Teaching Pharmacology. B.B. Pond. East Tennessee State University Gatton College of Pharmacy.
661. ALCOHOL Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D7 661.1 Divergent Influence of Binge Drinking and Subsequent Intermittent Stress on Drinking Behaviors and Select Brain Protein Levels in Male and Female Mice. L.L. Devaud, A. Garcia, M. Perius, D.A. Finn. Pacific University Oregon and Oregon Health & Sciences University. D8 661.2 Effects of Sequential Exposure to Ethanol and Methamphetamine on Tissue Contents of Dopamine, Serotonin and Glutamate in Wistar Rats. A.H. Almalki, S.C. Das, F.S. Alshehri, Y.S. Althobaiti, Y. Sari. University of Toledo.
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D9 661.3 Effects of Clavulanic Acid on Ethanol Intake and Glial Glutamate Transporters Expression in Alcohol Preferring Rats. A.Y. Hakami, Y. Sari. University of Toledo. D10 661.4 Organic Cation Transporter 3 Upregulation in Serotonin Transporter Deficient Mice Potentiates EthanolInduced Serotonin Clearance Impairments. T.L. Gilman, R.E. Horton, N.L. Baganz, S.R. Alvarado, L.C. Daws. University of Texas Health Science Center at San Antonio. D11 661.5 Are Exon 11-Associated Variants of the OPRM Gene Involved in Alcohol Reward? T. Brown, S. Martinez, J. Xu, Y. Pan, G. Rossi. Villanova University, Long Island University and Memorial Sloan Kettering Cancer Center. D12 661.6 Cortical Circuit Dynamics During PunishmentResistant Alcohol Drinking. C.A. Siciliano, Y. Leow, C. Vander Weele, E. Kimchi, D. Xu, X. Chen, K.M. Tye. Massachusetts Institute of Technology. D13 661.7 PARP Mediates Binge Alcohol-Induced Neurodegeneration in Adult Rats. D.E. Kouzoukas, J.A. Schreiber, N.F. Tajuddin, S. Kaja, H. Kim, E.J. Neafsey, M.A. Collins. Loyola University Medical Center, Edward Hines Jr. VA Hospital and NIAAA.
662. DRUG EFFECTS ON LEARNING AND COGNITION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D14 662.1 Novel Lipophilic Carbonic Anhydrase Activators Protect Mice from Recognition Memory Deficits Produced by Scopolamine. R.K. Sanku, B. Draghici, Y. Pan, M. Ilies, E. Walker. Temple University. D15 662.2 Anti-Muscarinic Drug Effects on Murine Cognition: A Pilot Study. R. Theobald, A. Blanchard, C.J. Morgan. A.T. Still University of Hlth Sci and Truman State University. D16 662.3 Effects of Self-Administered Oxycodone on Learning and Cognitive Flexibility in Nonhuman Primates. B.D. Kangas, E.N. Porter, J. Bergman. Harvard Medical School and McLean Hospital. D17 662.4 Role of Phosphodiesterase 4D in Memory and Cognition. C. Zhang, Y. Xu, M. Gurney, J. O’Donnell. SUNYBuffalo and Tetra Discovery Partners LLC. D18 662.5 Combined Norepinephrine and Dopamine Reuptake Inhibition for Long-Term Memory Enhancement. M.M. Pantoni, S.G. Anagnostaras. UC San Diego. D19 662.6 Effects of Juvenile Methylphenidate on LongTerm Retention in Adulthood. M. McWaters, E. Anderson, L. Matuszewich. Northern Illinois University.
SUNDAY PHARMACOLOGY D20 662.7 A New Testing Paradigm for Evaluating the Motor and Non-Motor Symptoms of 6-Hydroxydopamine Lesions in Rats. R. Spry, M. Hibicke, D. Rogers, K. Rambacher, R. Hayslett, N. Moniri, K. Murnane. Mercer University. D21 662.8 Discriminative Stimulus Effects of Novel Carbonic Anhydrase Activator B. D117. T.A. Spoon, R.K. Sanku, B. Draghici, M.A. Ilies, E. Walker. Temple University School of Pharmacy. D22 662.9 Methamphetamine Augments HIV-1 Tat Mediated Memory Deficits by Altering the Expression of Synaptic Proteins and Neutrophic Factors. A. Nookala, A. Kumar. University of Missouri Kansas City. D23 662.10 The Dual Effect of HIV-1 Tat and Methamphetamine on Dopamine Transporter Function. C.N. Appadoo, D. Sambo, T. Alonge, B. Harvey, H. Khoshbouei. University of Florida. D24 662.11 Endogenous Melatonin Decreases Place Preference for Methamphetamine Through a Learning and Memory Independent Mechanism in C57BL/6 Mice. S.J. Clough, T. Kasahara, K.M. Veros, R.L. Hudson, M.L. Dubocovich. Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY and RIKEN Brain Science Institute, Japan. D25 662.12 Interactive Effects of Hormone Status and ?9-THC Administration on Memory in Female Rats. A.C. Fournett, P. Winsauer. Louisiana State University Health Sciences Center. D26 662.13 Learning and Memory Deficits in a Novel Mouse Model of Alzheimer’s Disease. K. Murnane, C. Daphney. Mercer University.
663. CENTRAL NERVOUS SYSTEM DRUG DEVELOPMENT Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Neuropharmacology Presentation time: 12:30 pm–2:30 pm D27 663.1 Comparative Studies of AMPA Receptor Positive Allosteric Modulators PF-04958242 and PF-04531686. J.R. Stolz, T. Ishii, G. Swanson. Northwestern University and Nippon Medical School, Japan. D28 663.2 Elucidating Functional Selectivity at the 5-HT2A Receptor. G. Billac, C. Nichols. LSU Health Sciences Center. D29 663.3 Structure-Guided Design for Agonist Selectivity with α7-NAChRs. G.A. Camacho-Hernandez, K. Kaczanowska, M. Harel, C. Beck, L. Doan, H. Binding, P. Taylor. University of California San Diego and Universidad Autonoma de Baja California, Mexico. D30 663.4 Novel Adenine-Based Inhibitors Define a Pharmacophore with Selectivity for the cAMP Sensor NCS-Rapgef2 Versus PKA, Epac and Adenylate Cyclase in Neuroendocrine Cell Lines. L.E. Eiden, R. Alvarez, M.V. Eiden, W. Xu, A.C. Emery. NIMH-IRP.
D31 663.5 Discovery and Optimization of ML417: A Potent and Highly Selective D3 Dopamine Receptor Agonist. A.E. Moritz, R. Free, W. Weiner, E. Akano, M. Bachani, T. Doyle, N. Southall, M. Ferrer, J.A. Javitch, J. Steiner, J. Aubé, K. Frankowski, D.R. Sibley. NIH, University of North Carolina and Columbia University. D32 663.6 The in Vivo Pharmacodynamic and Biopharmaceutical Characterization of a Novel Dual Mechanism, Rapid-Acting Antidepressant. J.N. Talbot, D.B. Rawlins, F. Movahedi, M.Y. Zhudeva, A. Vo, J. Phan, J. Dorigatti, G. Velazquez, R.D. Kirsh, V.K. Yellepeddi. Roseman University of Health Sciences. D33 663.7 The Rho-Kinase Inhibitor, Fasudil, Has Antidepressant-Like Efficacy in Adolescent Mice. L. Shapiro, S. Gourley. Emory University.
664. GPCRS I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D34 664.1 β2-Adrenergic Receptor Control of Endosomal PTH Receptor Signaling via Gβγ. F. Jean-Alphonse, V. Wehbi, J. Chen, J. Taboas, K. Xiao, J. Vilardaga. University of Pittsburgh. D35 664.2 Functional Selectivity of GPCR-Directed Drug Action Through Location Bias. R. Irannejad. UCSF. D36 664.3 PAR1 and P38 MAPK Regulation of Endothelial Pro-Inflammatory Responses. C. Rada, N. Grimsey, I. Canto, J. Trejo. UCSD. D37 664.4 Optimization of a Novel D2 Dopamine Receptor Antagonist Scaffold Reveals Exceptionally Selective and Potent Lead Molecules. M.M. Day, A.E. Dulcey, D. Bayron, C.R. Stang, A.E. Moritz, T. Doyle, J.A. Javitch, N.T. Southall, M. Ferrer, J.J. Marugan, D.R. Sibley, R. Free. NIH/NINDS, NIH/NCATS and Columbia University. D38 664.5 A Critical Role for Transmembrane Five in Regulating Biased Signaling of the D2 Dopamine Receptor. E.C. Gonye, A.M. Moore, L.S. Chun, A.E. Moritz, L. Shi, D.R. Sibley, R. Free. NINDS/NIH and NIDA/NIH. D39 664.6 Structural Basis for Regulation of GPR56 by Its Alternatively Spliced Extracellular Domains. D. Arac. University of Chicago. D40 664.7 Structural and Functional Studies of LatrophilinFamily Adhesion G-Protein Coupled Receptors. K. Leon, Y.C. Lu, O. Nazarko, R. Sando, G. Salzman, T. Südhof, D. Araç University of Chicago and Stanford University. D41 664.8 Adhesion G Protein-Coupled Receptor Activation by Novel Small Molecule Modulators. H.M. Stoveken, A.V. Smrcka, G.G. Tall. University of Michigan and University of Rochester. D42 664.9 Delta Opioid Receptor Antagonism/Inverse Agonism and Its Effect on Mu Opioid Receptor Signaling in SH-SY5Y Cells. N. Griggs, H. Mosberg, J. Traynor. University of Michigan.
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PHARMACOLOGY SUNDAY D43 664.10 Role of GPCRs and Gαs in the Antidepressant Action of Ketamine. N. Wray, J. Schappi, M.M. Rasenick. University of Illinois at Chicago, University of Illinois College of Medicine and Jesse Brown VAMC. D44 664.11 GPCRs in Pulmonary Arterial Smooth Muscle Cells as Novel Targets in Pulmonary Arterial Hypertension. M.W. Gorr, K. Sriram, P.A. Insel. University of California San Diego. D45 664.12 Identifying Receptor-Ligand Interactions That Drive Gβγ-Dependent Signaling. R.B. Cameron, C.B. Beeson, R. Schnellmann. Medical University of South Carolina and University of Arizona. D46 664.13 Leveraging a Novel ITIM Motif in GPCRs for Targeted Antibody Design. L.T. Belcastro, A. Jancina, C. Adams, R.D. Paulukinas, C.C. Moore. Cancer Biology Program, The Wistar Institute and University of the Sciences, Philadelphia College of Pharmacy and USciences.
665. HETEROTRIMERIC G PROTEINS AND G PROTEIN MODULATORS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D47 665.1 Identification of Binding Sites for Small Molecule Modulators of Gβγ Signaling. I.J. Fisher, S. Connelly, M. Dumont, A. Smrcka. University of Rochester and University of Michigan. D48 665.2 Critical Role of R7 Binding Protein in the Sensation of Acute and Pathologic Itch. M. Pandey, J. Zhang, P. Adikaram, S.K. Mishra, B. Harris, J.F. Kahler, A. Loshakov, R. Sholevar, A. Genis, M. Hoon, R. Neubig, W.F. Simonds. NIDDK, NSCU, NIDCR and Michigan State University. D49 665.3 Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis. Y. Xie, H. Jiang, Q. Zhang, S. Mehrotra, P.W. Abel, M.L. Toews, D.W. Wolff, S. Rennard, R.A. Panettieri Jr., T.B. Casale, Y. Tu. Creighton University School of Medicine, University of Nebraska Medical Center, University of South Carolina School of Medicine Greenville, AstraZeneca, United Kingdom, University of Pennsylvania and University of South Florida School of Medicine. D50 665.4 Functional Mechanisms of Novel G Protein Inhibitor Ligands as Vasodilators. M.M. Meleka, M. Medcalf, K.D. Moeller, P. Osei-Owusu. Drexel University and Washington University. D51 665.5 Identification of Novel Small Molecule Stabilizers of RGS4 Protein Levels. B. Karaj, B. Sjogren, R.R. Neubig. Michigan State University. D52 665.6 Molecular Characteristics of FBXO44Mediated RGS2 Protein Degradation. B. Sjogren. Michigan State University. D53 665.7 RGS2 Modulates the Selection of Gαi/o Subtype Involved in Dopamine D2 Receptor Signaling. D.J. Luessen, T.P. Hinshaw, H. Sun, R. Chen. Wake Forest School of Medicine.
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D54 665.8 Investigating Regulator of G-Protein Signaling (RGS) Protein Dynamics by Hydrogen/Deuterium Exchange. V.S. Shaw, A.L. Schilmiller, H. Vashisth, R.R. Neubig. Michigan State University and University of New Hampshire. D55 665.9 Distribution of Activator of G-Protein Signaling 3 Within the Aggresomal Pathway: Role of Serine/Threonine Residues in the G- Protein Regulatory Domain and Lysosomal Processing. A. Vural, S. Oner, D. Ma, S.M. Lanier. Department of Pharmacology, Wayne State University School of Medicine, Istanbul Medeniyet University, Goztepe Research and Training Hospital, Turkey, Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara. D56 665.10 Cutting the Brakes to Prevent Type 2 Diabetes Onset: Augmenting Insulin Secretion and Conserving Pancreatic Beta-Cell Mass by Deleting Gαz. J. Wisinski, A. Reuter, M. Kimple. University of Wisconsin-Madison. D57 665.11 Structural Basis for Activation of Gαi by NonReceptor Guanine Nucleotide Exchange Modulators (GEMs). N.A. Kalogriopoulos, S. Rees, N. Aznar, N. Sun, G. Chang, P. Ghosh, I. Kufareva. University of California-San Diego. D58 665.12 Priming GPCR Signaling Through the Synergistic Effect of Two G Proteins. T.M. Gupte, R.U. Malik, R.F. Sommese, M. Ritt, S. Sivaramakrishnan. University of Minnesota and Twin Cities. D59 665.13 The MAPK Pathway Bisects Heterotrimeric G Protein Signaling Through Control of G Protein Subunit Biosynthetic Protein Folding. M.M. Papasergi-Scott, B.R. Patel, M. Gabbay, G. Tall. University of Rochester and University of Michigan. D60 665.14 Effects of Osteoblast-Specific Gαs OverExpression on Skeletal Development Using a Transgenic Mouse Model. L. Zhang, K. Sugamori, C. Claridge, A. Dela Cruz, J. Mitchell, M. Grynpas. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Canada and University of Toronto, Canada. D61 665.15 Targeting and Delivery of Heterotrimeric G-Proteins to Primary Cilia. C. Edwards, N. Lambert. Medical College of Georgia.
666. DRUG DISCOVERY AND DEVELOPMENT: GENERAL Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Discovery and Development Presentation time: 12:30 pm–2:30 pm D62 666.1 Computational Prediction of Off-Target Pharmacology for Discontinued Drugs. M. Rao, M. Liguori, S. Mantena, S. Mittelstadt, E. Blomme, T. Van Vleet. AbbVie. D63 666.2 The Effect of Pentadecapeptide BPC 157 on Episcleral Vein Cauterization Model in Rats. T. Kralj, A. Kokot, K. Kasnik, D. Drmic, M. Zlatar, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia, Faculty of Medicine and J.J. Strossmayer University of Osijek, Croatia.
SUNDAY PHARMACOLOGY D64 666.3 Optimal Strategies for Convection Enhanced Delivery (CED) of DNA Brain-Penetrating Nanoparticle (DNABPN) for Glioblastoma (GBM) Treatment. K. Negron, A. Ali, B. Lu, C. Zhang, J. Hanes, J. Suk. Johns Hopkins School of Medicine. D65 666.4 Damaging Effect of Retrobulbar L-NAME Application in Rats Counteracted by Stable Gastric Pentadecapeptid BPC 157. M. Zlatar, A. Kokot, L. Batelja Vuletic, T. Kralj, D. Drmic, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia, Faculty of Medicine and J.J. Strossmayer University of Osijek, Croatia. D66 666.5 Esophageal Cytoprotection in Rats. Stable Gastric Pentadecapeptide BPC 157 and Omeprazole. M. Peklic, A. Boban Blagaic, T. Becejac, J. Suran, D. Drmic, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia and University of Zagreb Faculty of Veterinary Medicine, Croatia. D67 666.6 Chlorpromazine Hydrochloride Suppresses Visceral Hypersensitivity to Colorectal Distension in a Rat Model of Irritable Bowel Syndrome. T. Asano, M. Takenaga. St. Marianna University, Japan. D68 666.7 Quantitative Tissue Distribution and Pharmacokinetics of IW-1973, a Novel Clinical-Stage sGC Stimulator, After Oral Administration in Rats. A. Banijamali, J. Wakefield, T. Barden, A. Carvalho, D.R. Zimmer, M. Currie, K. Hall, E. Solon, J. Masferrer, M. Ribadeneira. Ironwood Pharmaceuticals and QPS. D69 666.8 Biological Activity of ResveratrolHydroxycinnamic Acid Ester Conjugates. A.J. Urbaniak, K. Kacprzak, F.S. Senol, I. Erdogan Orhan, A. RadominskaPandya. University of Arkansas for Medical Science, Adam Mickiewicz University, Poland and Gazi University, Turkey. D70 666.9 Structure Activity Relationship Studies for Inhibitors of Type 1 and Type 8 Adenylyl Cyclase Isoforms. M. Soto Velasquez, N. Rana, D. Alongkronrusmee, K.F. Ejendal, K. Kyei-Baffour, R.M. Van Rijn, M. Dai, M.A. Lill, V.J. Watts. Purdue University.
667. GENERAL TOXICOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Toxicology Presentation time: 12:30 pm–2:30 pm D71 667.1 Sub Acute Effect of Pirimiphos Methyl (Actellic 2% Dust) on Oxidative Stress in Albino Rats. C.I. Nosiri, C. Anyanwu, A.O. Ibeh. Abia State University, Nigeria, Bizmart Pharmaceuticals. D72 667.2 Aryl Hydrocarbon Receptor Activation Differentially Alters Cholera Toxin-Specific IgA Levels in Feces and Serum. A. King, E. Gawronska, M. Metten, G. DeKrey. University of Northern Colorado and Colorado State University. D73 667.3 Modulation of the Aryl Hydrocarbon Receptor Protein Levels by p23 Is Hsp90-Independent. B. Pappas, M. Cheung, K. Ngo, T. Chang, C. Ng, W.K. Chan. University of the Pacific.
D74 667.4 Evaluation of the Glycan Receptor Ligand Mannan as a Potential Mitigation Strategy for Non-TargetRelated Toxicities of Antibody-Drug Conjugates. R. Ciurlionis, S.R. Mantena, C.J. Dunn, M. Klapczynski, W.R. Buck, T.R. van Vleet. Abbvie and Inc. D75 667.5 Cytotoxicity of Ethanol Extracts from Glanded and Glandless Cottonseed in Cultured Mouse RAW Macrophages. H. Cao, K. Sethumadhavan. USDA-ARS. D76 667.6 Calabash Clay (Nzu) Affects Pregnancy in Whistar Albino Rats. J.S. Aprioku, E.M. Ogwo-ude. University of Port Harcourt, Nigeria. D77 667.7 Evaluation of Embryotoxicity and Teratogenicity of Maltodextrin-Coated Cadmium Sulfide Quantum Dots. J. Sánchez, J. Reyes-Esparza, L. Rodriguez-Fragoso. Universidad Autónoma del Estado de Morelos, Mexico and Universidad Autonoma del Estado de Morelos, Mexico. D78 667.8 In Vivo and in Vitro Effects of Work Site Fracking Sand Dust (FSD) Inhalation on Rat Lung: Dose- and Time-Response Evaluation. J.S. Fedan, J.A. Thompson, K.A. Russ, D. Newcomer, W. McKinney, A.M. Cumpston, M.C. Jackson, J.S. Reynolds. National Institute for Occupational Safety and Health. D79 667.9 Investigation of Pyrrolizidine Alkaloid-Induced Pulmonary Toxicity. W. Lian, J. Ma, C. Wong, L. Zhu, G. Lin. The Chinese University of Hong Kong, People’s Republic of China, Joint Research Laboratory of Promoting Globalization of Traditional Chinese Medicines between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China. D80 667.10 The ProS Peptide of Porcine Cathelicidins Is an Active Component of Swine Concentrated Animal Feeding Operations (CAFOs) Dust That Mobilizes Calcium and Stimulates Proliferation in Human Airway Smooth Muscle Cells. M.L. Toews, N.A. Schulte, Y. Tu, R.A. Panettieri; Jr, D.J. Romberger, G. Tian. University of Nebraska Medical Center, Creighton University School of Medicine, University of Pennsylvania and VA Nebraska-Western Iowa Healthcare System. D81 667.11 Indoxyl Sulfate Involves Abnormality of Iron Metabolism Through Hepcidin Regulation. H. Hamano,Y. Ikeda, H. Watanabe, Y. Horinouchi, Y. Izawa-Ishizawa, K. Ishizawa, K. Tsuchiya, T. Tamaki. Tokushima University Graduate School, Japan and Tokushima University Hospital, Japan. D82 667.12 Differential Cardiovascular Physiology and Pathology in Selected Lineages of Miniature Swine and Comparison to Human. A.M. Stricker-Krongrad, D. Brocksmith, G.M. Bouchard. Sinclair Research Center LLC and Sinclair Bio Resources. D83 667.13 The Anti-Apoptotic Effect of Methanol Leaf Extract of Azadirachta indica on Lead Acetate-Induced Apoptosis in Cardiac and Renal Tissues of Male Wistar Rats. T.E. Adeyeoluwa, A.A. Oyagbemi, A.A. Adedapo, T.O. Omobowale. University of Ibadan, Nigeria. D84 667.14 Stable Gastric Pentadecapeptide BPC 157 Antagonizes Hydrogen Peroxide Induced Oxidative Stress in Drosophila melanogaster. A. Filosevic, R. Andretic Waldowski, T. Vidovic, P. Sikiric, D. Drmic. Department of Biotechnology, University of Rijeka, Croatia, School of Medicine and University of Zagreb, Croatia.
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668. EXPRESSION AND REGULATION OF DRUG METABOLISM ENZYMES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D85 668.1 Efavirenz Treatment Activates XBP1 Splicing in Primary Hepatocytes: A Comparison Across Species and an Investigation Into the Role of PXR. C.J. Heck, N.N. Bumpus. Johns Hopkins University School of Medicine. D86 668.2 Transcriptional Regulation of Disease-Drug Interactions. W. Xie. University of Pittsburgh. D87 668.3 Structural Differences in Gut Microbiota Lead to Altered Hepatic Expression of Drug Disposition Genes (DDG) in Mice. Y. Guo, S.-J. Cho, E. Chung, J.-S. Park, H. Jeong. University of Illinois at Chicago. D88 668.4 atRA Upregulates SHP Expression Through RXR Activation. K. Won, H. Jeong. University of Illinois at Chicago. D89 668.5 RNA Sequencing Analysis of Commensal Microbial Regulation of Host Intestinal Transcriptome. Z.D. Fu, F.P. Selwyn, J.Y. Cui. University of Washington. D90 668.6 Effect of Novel Interactions Between Gut Microbiome and PBDEs on the Regulation of Intestinal Drug-Processing Genes Expression. S. Lee, C. Li, J.Y. Cui. University of Washington. D91 668.7 Crypt Organoids Culture as an in Vitro Model in Studying Regulation of Xenobiotic Metabolism and DrugInduced Cytotoxicity. S. Chen, W. Lu, E. Rettenmier, M. Yueh. University of California at San Diego. D92 668.8 Elucidating the Effect of DNA Methylation on the Regulation of Human Neonatal Fc Receptor (FcRn). D.C. Ferguson, J.G. Blanco. University at Buffalo. D93 668.9 Comparison of Expression Profiles of DrugMetabolizing Enzymes Between Human Liver and the Hepatic Cell Lines Hepg2, Hep3b, and Huh7: A Parallel Reaction Monitoring (PRM)-Based Targeted Proteomics Study. J. Shi, X. Wang, H. Zhu. University of Michigan. D94 668.10 Novel Interactions Between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals PBDEs. C. Li, S. Cade, I. Schultz, L. Kuo, T.K. Bammler, J. Cui. University of Washington and Pacific Northwest National Laboratory. D95 668.11 Differential Gut Microbiota Modulates the Susceptibility to Acetaminophen-Induced Hepatotoxicity. S. Cho, G. Chlipala, S. Green, H. Lee, H. Jeong. University of Illinois at Chicago. D96 668.12 Global Gene Expression Changes Between Human Prenatal and Pediatric Liver. C.A. Vyhlidal, M. Xiong, D.P. Heruth, S.Q. Ye. Children’s Mercy Kansas City and University of Missouri-Kansas City. D97 668.13 L-Tryptophan and Bacterial Modulation of Intestinal and Hepatic Gene Expression. J.L. Dempsey, C.Y. Li, J.Y. Cui. University of Washington.
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D98 668.14 Downregulation of Intestinal P450 Enzymes in a Mouse Model of Ulcerative Colitis and the Impact on P450Mediated Drug Metabolism. X. Fan, X. Ding, Q. Zhang. New York State Department of Health, State University of New York at Albany and SUNY Polytechnic Institute. D99 668.15 Genomic and Proteomic Approaches to Identify Mechanism of Regulation of Cytochrome P450 3A Enzymes. G. Taneja, W. Jiang, S. Maity, C. Coarfa, B. Moorthy, R. Ghose. University of Houston and Baylor College of Medicine. D100 668.16 Regulation of Hepatic CYP3A4 by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. M. Crosby, D.S. Riddick. University of Toronto, Canada. D101 668.17 Protein Abundance of Phase I and II Drug Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhosis Livers. B. Prasad, K. Johnson, G. Xiao, Y. Lai, C. Lee, A.S. Ray, M. Liao, X. Chu, L. Salphati, A. Mathias, W. Humphreys, C.E. Hop, S. Kumer, J.D. Unadkat. University of Washington, Biogen, Bristol-Myers Squibb, Ardea Bio, Gilead Sciences, Takeda Pharmaceuticals International Co., Merck & Co., South San Francisco, Genentech and University of Kansas Medical Center.
669. PHASE I DRUG METABOLISM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D102 669.1 Physical Interactions of Cytochrome b5 with Human Cytochrome P450 Enzymes. A.G. Bart, E.E. Scott. University of Michigan. D103 669.2 Validation of Ru(II)-Caged Abiraterone as a Chemical Tool for Controlling CYP17A1 Activity with Visible Light. A. Li, R. Yadav, J.K. White, M.K. Herroon, I. Podgorski, C. Turro, E.E. Scott, J.J. Kodanko. Wayne State University, University of Michigan, The Ohio State University, Barbara Ann Karmanos Cancer Institute. D104 669.3 Interindividual Variability in CYP3A Activity: Influence on CYP3A-Related Herb-Drug Interactions from Selected Natural Health Supplements in Human Liver. S. Deb, A. Bukowska, N. Heo, I. Rajab. Roosevelt University College of Pharmacy. D105 669.4 In Vitro Metabolite Profiling of Sildenafil Based on Metabolomics Approach. S. Kim, J. Jo, O. Kwon, S. Lee. Kyungpook National University, Republic of Korea. D106 669.5 Comparison of Cytochrome P450 3A4 and 3A7 with Azole Inhibitors. M.P. Godamudunage, J.N. Lampe, E.E. Scott. University of Michigan and University of Kansas Medical Center. D107 669.6 Altered CYP19A1 and CYP3A4 Activities Due to Mutations in the Flavin Mononucleotide Binding Domain of Human P450 Oxidoreductase. S.S. Udhane, S. Parween, N. Kagawa, A.V. Pandey. Medical College of Wisconsin Cancer Center, University Children’s Hospital Bern, Switzerland, Nagoya University, Japan and University of Bern, Switzerland.
SUNDAY PHARMACOLOGY D108 669.7 Benzop(a)pyrene in Cigarette Smoke Enhances HIV-1 Replication in Monocytic Cells: Potential Role of Cytochrome P450s and Oxidative Stress. S. Ranjit, N.M. Midde, N. Sinha, S. Kumar. University of Tennessee Health Science Center. D109 669.8 Physical Complexes Formed by CYP1A2 and CYP2B4 Are Associated with Altered P450 Activity. J.P. Connick, J.R. Reed, W.L. Backes. LSUHSC New Orleans. D110 669.9 Characterization of Nefazodone TimeDependent Inhibition of Cytochrome P450 3A. Z. Wang, B.M. Rock, J.T. Pearson, T. Tran, D.A. Rock. Amgen. D111 669.10 Tissue Specific Regulation of CYP26 Enzymes. S. Tripathy, N. Isoherranen. University of Washington. D112 669.11 Tipping the Balance of Hepatic CYP3A4 Activity Through Integrin-Mediated Outside-In and Inside-Out Signaling. K. Jonsson-Schmunk, M. Croyle. University of Texas at Austin. D113 669.12 Cytochrome P450 1A2 N-Terminal Site Directed Mutagenesis: Effects on Lipid Microdomain Localization. C.S. Lott, J.W. Park, J.R. Reed, W.L. Backes. Louisiana State University Health Sciences Center New Orleans. D114 669.13 Effect of Genotype, Age and Gender on Hepatic Abundance of Flavin Monooxigenase 3. M. Xu, D. Bhatt, K. Chaw, C. Yeung, B. Prasad. University of Washington. D115 669.14 Nicotine Metabolism by the Flavin Monooxygenase (FMO) Family of Enzymes. Y. Perez-Paramo, C. Watson, G. Chen, P. Lazarus. Washington State University. D116 669.15 ecoAO: A Simple System for the Study of Drug Metabolism by Human Aldehyde Oxidase. E.M. Paragas, S. Humphreys, J. Min, C. Joswig-Jones, J. Jones. Washington State University. D117 669.16 In Vitro Assessment of Drug Interaction Potential of Licorice Extracts. A. Tonsing-Carter, G. Li, R. van Breemen. University of Illinois at Chicago. D118 669.17 Impact on Drug Responses in Adult Life by Drug Treatment at the Neonatal Age. S. Piekos, L. Chen, X. Zhong. University of Connecticut. D119 669.18 Steroid Metabolism in Human Prostate Cancer Tissue: Effect of CPY17 Inhibitors. S. Deb, M.Y. Chin, S. Pham, H. Adomat, A. Hurtado-Coll, M. Gleave, E.S. Guns. Roosevelt University College of Pharmacy and The Vancouver Prostate Centre at Vancouver General Hospital, Canada. D120 669.19 A Comprehensive Functional Assessment of CES1 Nonsynonymous Variants. X. Wang, N. Rida, J. Shi, H. Zhu. University of Michigan. D121 669.20 Best Practices for Robust LC-MS/MS Quantification of Drug Metabolizing Enzymes and Transporters to Predict Inter-Individual Variability: Case Examples of Hepatic Cytosolic ADHs and ALDH1A1. D. Bhatt, B. Prasad. University of Washington.
670. AUTOPHAGY AND APOPTOSIS IN CANCER Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cancer Pharmacology Presentation time: 12:30 pm–2:30 pm D122 670.1 Globular Adiponectin Induces Endoplasmic Reticulum Stress and Autophagy in Macrophages. H. Oh, N. Tilija Pun, P.K. Raut, E. Kim, A. Khakurel, A. Shrestha, P. Park. Yeungnam University, Republic of Korea. D123 670.2 Autophagy Activation by Leptin Mediates the Growth of Breast Cancer Cells via Estrogen Receptor Signaling: Involvement of AMPK/FoxO3A Axis. P.K. Raut, N. Tilija Pun, E. Kim, A. Khakurel, H. Oh, A. Shrestha, P. Park. Yeungnam University, Republic of Korea. D124 670.3 LXRa Inhibits Autophagy in Hepatocytes Through ATG4B Inhibition. Y. Kim, H. Nam, S. Kim. Seoul National University, Republic of Korea. D125 670.4 Modulation of Autophagy Proteins in Response to a Compound Designed as a Sigma-2 Receptor Agonist Derived from Tamoxifen. C.R. Stang, B.R. Adams, A.D. Faler, B.R. Schuler, D.H. Kinder, P. Sabol, L. Carlston, R.A. Schneider. The University of Findlay and Ohio Northern University. D126 670.5 VJR-TZ-18: Novel Phosphatidylinositol-3Kinase (PI3K) Delta Inhibitor Exerts Antitumor Activity via Induction of Autophagy and Apoptosis in Breast Cancer in Vitro and in Vivo. G. Lalita, G. Jagadeesh Kumar, T. Dinesh, V. Jayathirtha Rao, V. G M. Naidu. NIPER-Hyderabad, India and IICT-Hyderabad, India. D127 670.6 Induction of Autophagy and Apoptosis in Triple-Negative Breast Cancer Cells by LT-IIc, a Type II HeatLabile Enterotoxin. Y. Heakal, S. Girald Berlingeri, J. Hu, M. Federowicz, T.D. Connell, P. Masso-Welch. D’Youville College School of Pharmacy, Jacobs School of Medicine and University at Buffalo. D128 670.7 Cyproterone Acetate Enhances TRAIL-Induced Androgen-Independent Prostate Cancer Cell Apoptosis via Upregulation of Death Receptor 5. L. Chen, D.W. Wolff, Y. Xie, M. Lin, Y. Tu. Creighton University School of Medicine, University of South Carolina School of Medicine and University of Nebraska Medical Center. D129 670.8 Chemotherapeutic Effect of Calcium Sulfide Nanostructures in Non-Small Cell Lung Carcinoma by Intrinsic and Extrinsic Apoptotic Pathways. M.M. Figueroa Rosado, K. Muñoz Forti, G. Arroyo Martínez, T. Vega Carattini, A. Ruiz Rivera, P. Santiago, M.E. Castro, E. Suárez. Pontifical Catholic University, University of Puerto Rico at Ponce, Ponce Health Sciences University and University of Puerto Rico at Mayagüez. D130 670.9 Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Cell Through the Reactive Oxygen Species Mediated Apoptosis. J. Hsiao, P. Chou, M. Sheu. China Medical University, Taiwan and Hungkuang University, Taiwan.
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PHARMACOLOGY SUNDAY D131 670.10 Induction of Apoptosis and Generation of Reactive Oxygen Species by Novel Chalcone Derivatives. C.R. Stang, B.R. Adams, A.D. Faler, B.R. Schuler, A.M. Eichel, M.J. Dick, C.B. Orahood, T.L. Whited, P. Rao, R.W. Dudley, R.S. Khupse, R.A. Schneider. The University of Findlay. D132 670.11 Evaluation of Seahorse XF Cell Mito Stress Test for Detection of Mitochondrial Dysfunction Using Prototypical Mitochondrial Toxicants in the PC-3 Cell Line. J.L. Zhang, C. Krause, R. Ciurlionis, T.L. Sharapova, J. Wilsbacher, S. Ackler, T. Van Vleet, M.J. Liguori. Abbvie and Inc. D133 670.12 RAGE Upregulation Confers a Proliferative Phenotype to PANC-1 Pancreatic Cancer Cells. P. Swami, S. Vetter, E. Leclerc. North Dakota State University.
671. CELL SIGNALING AND CANCER THERAPEUTICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cancer Pharmacology Presentation time: 12:30 pm–2:30 pm D134 671.1 Tackling Liver Cancer by a Novel Combination Between OSU-2S and Sorafenib. H.A. Omar, M.F. Tolba, J. Hung, T.H. Al-Tel. University of Sharjah, United Arab Emirates, Beni-Suef University, Egypt, Ain Shams University, Egypt and Chia Nan University of Pharmacy and Science, Taiwan. D135 671.2 Peptide Ligand of the Epidermal Growth Factor Receptor for Sensitizing Lung Cancer Cells to Gefitinib. Z.A. ALHamar, T. Andey. MCPHS. D136 671.3 The Role of p90 Ribosomal S6 Kinase in Lung Adenocarcinoma and as a Mediator of the Cytotoxic Effects Induced by Cisplatin. F. Mraiche, N. Abdulrahman. Qatar University, Qatar. D137 671.4 Comparison Study of the Effects of Zerumbone and AG490 in Human Renal Cell Carcinoma on the Activation of the Janus Kinase Pathway and Cell Survival. Z. Walker, A. Duncan, T. Bellomo, K. Budd, A. Polina, J. Hafron, A. BanesBerceli. Oakland University and William Beaumont Hospital. D138 671.5 Aryl Hydrocarbon Receptor/Cytochrome P4501 Pathway Mediates Breast Cancer Stem Cells Expansion Through β-Catenin/Akt Activation and Pten Inhibition. A.O. AlDhfyan, A.R. Alhoshani, H.M. Korashy. King Saud University, Saudi Arabia and King Faisal Specialist Hospital and Research Center, Saudi Arabia. D139 671.6 Non-Cannonical Notch Signaling Pathways Regulate Breast Cancer Stem-Like Cells Function in Triple Negative Breast Cancer. F. Hossain, C. Sorrentino, A. Bilyeu, J. Crabtree, A. Pannuti, T. Golde, B. Osborne, L. Miele. LSUHSC, University of Florida and Umass Amherst. D140 671.7 Reversal of the ERα Negative Receptor in Human Breast Cancer Cells by Dichloro-Napthoquinone Analog. A.G. Robinson, R.L. Copeland. Howard University. D141 671.8 Examining the Role of ARRDC3 in Regulation of PAR1 Trafficking and Signaling in Invasive Breast Carcinoma. A. Arakaki. UC San Diego.
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D142 671.9 Antiproliferative and Antimigratory Effects of Enoxaparin on the Lung Adenocarcinoma A549 Cell Line. A. Alturkistani, V. Power-Charnitsky, N. Ghonem, M.M. Migliore. MCPHS University, Regis College and University of Rhode Island. D143 671.10 GPCRs as Novel Potential Therapeutic Targets in Cancer. P.A. Insel, K. Sriram, S.Z. Wiley, R.P. French, A.M. Lowy. UCSD. D144 671.11 cAMP-Phosphodiesterase PDE4D as a Target for Colon Cancer Therapy. A. Boyd, G. Baskar, T. Petty, A. Keeton, G. Piazza, W. Richter. University of South Alabama. D145 671.12 Berberine Derivatives as Multi-Kinase Inhibitors of MAP Kinase and PI3K Pathways: Molecular Modelling, Molecular Dynamics Simulations, and in Vitro Evaluation. P. Jabbarzadeh Kaboli, P. Ismail, K. Ling. Universiti Putra Malaysia, Malaysia. D146 671.13 The β-Blockers Carvedilol and Nebivolol Inhibit Neoplastic Transformation Through a β2-Adrenergic Receptor Independent Mechanism. K.H. Cleveland, S. Chen, L. Guo, B.T. Andresen, Y. Huang. Western University of Health Sciences and US Food and Drug Administration National Center for Toxicological Research. D147 671.14 A Constitutive Androstane Receptor (CAR) Inhibitor CINPA1 as a Tool to Understand Receptor Structure and Function. M.T. Cherian, S.C. Chai, M.A. Casal, T. Chen. St Jude Children’s Research Hospital and University of Pittsburgh. D148 671.15 Etrasimod, a Novel Sphingosine-1-Phosphate Receptor (S1PR1) Modulator, Lacks Functional Activity at S1P2 Receptors. J.W. Adams, D.J. Unett, X. Chen, I. Gaidarov. Arena Pharmaceuticals, Inc., Beacon Discovery and Inc. D149 671.16 Comparison of the Rexinoids Bexarotene and Pyrimidine-Bexarotene in a Preclinical Model of Lung Carcinogenesis. D. Zhang, A.S. Leal, S. Carapellucci, K. Zydeck, N. Chaaban, M.B. Sporn, C.E. Wagner, K.T. Liby. Michigan State University, Dartmouth Medical School and Arizona State University.
672. ION CHANNELS AND CARDIOVASCULAR PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D150 672.1 Apelin Alters Vasomotor Tone in Cerebral Arteries by Inhibiting Endothelium-Dependent Relaxations That Are Mediated by Activation of Large Conductance, Calcium-Activated K (BKCa) Channels. A. Mughal, C. Sun, S.T. O’Rourke. North Dakota State University. D151 672.2 Activation of Mitochondrial KATP Channels by Diazoxide Stimulates Vascular Repair-Relevant Functions of Human CD34+ Cells by Activating Endothelial Nitric Oxide Synthase. S. Joshi, Y.P. Jarajapu. North Dakota State University.
SUNDAY PHARMACOLOGY D152 672.3 Nitric Oxide Inhibits Functional Coupling Among Endothelial TRPV4 Channels and Limits Vasodilation in Small Pulmonary Arteries. C. Marziano, K. Hong, E.L. Cope, S.S. Sonkusare. University of Virginia. D153 672.4 Muscarinic Cholinergic Receptors Regulate Oscillation of Intracellular Ca2+ in SteroidProducing Adrenocortical Carcinoma Cells. H. Sharthiya, N. Surachaicharn, Y. Shams, M. Arshad, P.G. Kopf, L.M. Malaiyandi, K.E. Dineley. Midwestern University. D154 672.5 The Cellular Mechanism of Bitter Taste Receptor Mediated Relaxation of Rat Aorta. W. Xin, Q. Chen. Southwest University, People’s Republic of China. D155 672.6 Functional Upregulation of STIM-1/Orai-1Mediated Store-Operated Ca2+ Entry Contributing to the Aortic Remodeling and Hypertension Development by Chronic EtOH Consumption. G.S. Bomfim, I. Méndez-López, J.A. ArranzTagarro, D.C. Musial, A.A. Carbonel, J.F. Padín, A.G. García, A.A. Jurkiewicz, N.H. Jurkiewicz. Federal University of São Paulo (UNIFESP)—Brazil, Brazil, Universidad Autónoma de Madrid (UAM)—Spain, Spain, Universidad Autónoma de Madrid (UAM) and Madrid—Spain, Spain. D156 672.7 Role of Transient Receptor Potential Canonical 5 (TRPC5) Channels in Vascular Tone Regulation. C. Liang. The Chinese University of Hong Kong, People’s Republic of China. D157 672.8 Characterisation of Mechanisms of Relaxation Induced by Omega-3 Polyunsaturated Fatty Acids (n-3 PUFA) EPA and DHA in Rat Aorta and Mesenteric Arteries: A Novel Role for IKCa and TRPV4 Channels in DHA Mediated Relaxation. A.J. McNeish, G.S. Cottrell, R. Limbu. The University of Reading, United Kingdom.
673. DIABETES AND CARDIOVASCULAR PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D158 673.1 Altered Spinophilin Interactions in the Pancreas of a Leptin Receptor Mutant (db/db) Model of Obesity. K.C. Stickel, D.S. Watkins, M.C. Edler, S. Dharmarajan, T.L. Belecky-Adams, N.F. Berbari, T.L. Mastracci, A.J. Baucum II. IUPUI, Indiana University School of Medicine and Indiana Biosciences Research Insitute. D159 673.2 Cardiac HMGB1/TLR4 Activation in PreType 2 Diabetes: A Potential Mechanism Triggering Diabetic Cardiovascular Complications. E. Vargas, Y. Li, M. CarrilloSepulveda. NYIT College of Osteopathic Medicine. D160 673.3 Hyperglycemia-Induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-Mediated Suppression of RPI3 in Diabetic Rats. H. Li, M.G. Irwin, Z. Xia. The University of Hong Kong, Hong Kong, Affiliated Hospital of Guangdong Medical University, People’s Republic of China.
D161 673.4 Myo-Inositol Concentration Is Strongly Reduced in the Renal Cortex of STZ-Diabetic Rats. M.C. Fonteles, D.B. Heimark, P.N. Uchoa, C.P. Aquino, N.R. Nascimento, C.F. Santos. Ceara State University, Brazil. D162 673.5 Structure Based Drug Design with Diabetic Retinopathy and Rage. S. Sriramoju, D. Evangelista, K. Goetz. Ardsley High School and NIH/NEI. D163 673.6 Mid-Term Exposure to Prednisone Is Less Detrimental Than Short-Term Dexamethasone on Glucose Homeostasis in Rats. N.X. Ribeiro, D.N. Melo, J.R. Sanches, L.M. França, A.G. Cappelli, A. Rafacho, I.C. Abrau, A.M. Paes. Federal University of Maranhão, Brazil and Federal University of Santa Catarina, Brazil. D164 673.7 SGLT1 Inhibition Has Modest Gastrointestinal Consequences in Mice and Rats. P.J. Hornby, F. Du, S. Hinke, N. Wallace, C. Cavanaugh, C. Bender, M. Jennis, Y. Liang, M. Gaul, G. Kuo, J. Lenhard. Janssen R&D. D165 673.8 Novel RAGE Antagonist, FPS-ZM1, Reverses Mesenteric Arteriolar Remodeling in Type 2 Diabetic db/db Mice. H. Labazi, P. McCallinhart, I. Sunyecz, A. Trask. The Research Institute at Nationwide Children’s Hospital and The Ohio State University. D166 673.9 Downregulation of Histone Deacetylase 9 (HDAC9) Is Associated with Vascular Calcification in Diabetic Mice. S.A. Benerofe, M. Carrillo-Sepulveda. NYIT College of Osteopathic Medicine. D167 673.10 The Aortic Function of Male UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rats: Possible Involvement of Potassium Channels. F. Akther, S. Shaligram, M.D. Karimi, J.L. Graham, K.L. Stanhope, P.J. Havel, R. Rahimian. University of the Pacific and University of California. D168 673.11 Targeting Cathepsin K to Promoted Diabetic Wound Healing. S. Nair, R. Guo, R. Nair, C. Zgheib, J. Xu, K.W. Liechty. University of Wyoming, Nutriwyo LLC and University of Colorado. D169 673.12 Dantrolene and Nimodipine Reduce Arterial Tone Synergistically in Aortic Rings from Type-1 Diabetic Rats. M. Roman, S. Alemar, J. Matias, M. Torres-Grajales, R. Zack, M. Morales, H. Torres, M. Crespo. University of Puerto RicoSchool of Medicine, Puerto Rico. D170 673.13 Functional Changes in Vascular Reactivity to Adenosine Receptors Activation in Type I Diabetic Mice. H. Labazi, B. Teng, S.J. Mustafa. Nationwide Children’s Hospital and West Virginia University. D171 673.14 Treatment with Captopril Enhances the Vascular Relaxation Induced by the Angiotensin II Type 2 Receptor (AT2R) Agonist CGP42112 in Diabetic Rats. R. Sabra. American University of Beirut, Lebanon. D172 673.15 FOXO1 Overactivation via Enhancing CD36 Exacerbates Myocardial Ischemia Reperfusion Injury in Diabetic Rats. D. Yan, Z. Xia. The University of Hong Kong, Hong Kong. D173 673.16 Critical Role for Adenylyl Cyclase 5 on L-Type CaV1.2 Channel Potentiation and Vasoconstriction During Diabetic Hyperglycemia. A.U. Syed, M.A. Nystoriak, M. Prada, M. Nieves-Cintrón, M.F. Navedo. University of CaliforniaDavis and University of Louisville.
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674. VASCULAR PHARMACOLOGY OF HEMOSTASIS AND THROMBOSIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D174 674.1 A Novel Role of Lassbio-788 in Inhibiting NFκB Mediated Signaling in Platelet of Hypercholesterolemic Rats. F.C. Brito, N.A. Motta, G.F. Lima, R. Lopes, E.J. Barreiro, A.E. Kummerle. Universidade Federal Fluminense, Brazil, Universidade Federal do Rio de Janeiro, Brazil and Universidade Federal Rural do Rio de Janeiro, Brazil. D175 674.2 Neutralization of Unfractionated Heparin (UFH) and a Bioengineered Heparin Dodecasccharide (12-mer) by Protamine Sulfate. A. Kouta, R. Duff, D. Hoppensteadt, W. Jeske, S. Abro, J. Fareed. Loyola Hemostasis & Thrombosis. D176 674.3 Anticoagulant Profiling of a Generic Enoxaparin and Its Comparison with Its Branded Version. S. Abro, D. Hoppensteadt, J. Fareed. Loyola Hemostasis & Thrombosis. D177 674.4 Comparative Anticoagulant Effects of Recombinant Thrombomodulin, Antithrombin, and Unfractionated Heparin, Hematological Implications. Z. Siddiqui, J. Fareed, P. Aggarwal, O. Iqbal, D. Hoppensteadt, S. Abro. University of Illinois and Loyola Hemostasis & Thrombosis. D178 674.5 Terminalia Methanol Extracts Inhibit the Amidolytic Activity of Human Activated Factor XII (Hageman Factor). H. Madkhali, A. Alharbi, Z. Ali, I. Khan, Z. ShariatMadar. Prince Sattam Bin Abdulaziz University, Saudi Arabia and University Of Mississippi. D179 674.6 RGS10 Serves as a Braking System for Platelet Hyperactivity. N.R. Hensch, Z.A. Karim, H. Qasim, F.T. Khasawneh. Western University of Health Sciences. D180 674.7 Withdrawn. D181 674.8 Novel Peptide Micellar Nanoformulation for Treatment of thrombotic Complications of Sepsis. M. Bae, L. Rusu, M. Castellon, X. Du, H. Onyuksel, R.D. Minshall. College of Medicine, University of Illinois at Chicago, College of Pharmacy and University of Illinois at Chicago. D182 674.9 A Prospective, Open Label Study to Evaluate the Pharmacokinetics of Dabigatran in Patients with NonValvular Atrial Fibrillation and Severe Renal Impairment Who Are Receiving Dabigatran Etexilate (75 mg Twice Daily). J. Martin, H. Esmaeili, R.C. Manuel, M. Petrini, S. Wiebe, H. Maas. Sharpe Strumia Research Foundation, Staburo GmbH, Germany, Boehringer Ingelheim Pharmaceuticals, Inc and Boehringer Ingelheim Pharma GmbH & Co. KG, Germany. D183 674.10 Effect of an Active Phosphatidylserine Species on Antigen-Specific Tolerance Induction Toward Factor VIII in Hemophilia a Mice. F.C. Yau, S.V. Balu-Iyer. University at Buffalo.
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D184 674.11 Slounase, a Snake Venom Hemocoagulase Combined with FXa, Enhances Hemostasis and Limits Bleeding in Both Normal and Hypocoagulant Conditions. R. Adili, X. Dai, B.X. Li, M. Holinstat. University of Michigan and Lee’s Pharmaceutical Holdings Limited, Hong Kong. D185 674.12 Loss of Rnase1 Produces Coagulation Abnormalities in Mice. E.R. Garnett, R.T. Raines. University of Wisconsin-Madison. D186 674.13 Polyphosphate-Conjugated Silica Nanoparticles (PolyP-SNPs) Attenuate Bleeding After Tail Amputation. K. Ploense, D. Kudela, S. Hammond, G. Stucky, T. Kippin. Cayuga Biotech and UC Santa Barbara. D187 674.14 Antithrombotic Activity of New Potassium Salt 2-[3-Bromine-1-(Thietanil-3)-1,2,4-Triazolil-5-Thio]acetic Acid. A.V. Samorodov, F.K. Kamilov, E.E. Klen, F.A. Khaliullin, A.R. Khalimov. Bashkirian State Medical University, Russian Federation. D188 674.15 Plasma Nucleosomes Correlate with Markers of Inflammation and Thrombosis in Patients with Sepsis-Associated Coagulopathy. A.T. Walborn, P. Patel, D. Hoppensteadt, M. Mosier, S. Statz, M. Rondina, J. Fareed. Loyola University Chicago and University of Utah. D189 674.16 Chronic Deep Vein Thrombosis: Pentadecapeptide BPC 157 Effect on Vein Thrombi. M. Siroglavic, J. Vukojevic, D. Drmic, A. Tvrdeic, S. Seiwerth, P. Sikiric. School of Medicine and University of Zagreb, Croatia. D190 674.17 Polyphenol Rich Extract of Syzygium cumini (L.) Skeels Leaves Decreases Platelet Aggregation and Inhibits Reductase Activity of Protein Disulfide Isomerase. S.A. da Silva, H.R. Sousa, R. Gaspar, J. Fontelles, A.E. Trostchansky, A. Paes. Federal University of Maranhão, Brazil, UFMA, Brazil and Republic University of Uruguay, Uruguay. D191 674.18 Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents. W. Jeske, O. Bouchard, D. Hoppensteadt, P. Maia, A. Silva De Castro, E. Kumar, N. Gular, D. Kahn, J. Walenga, Y. Yao, F. Jawed. Loyola University Chicago, Ronnsi Pharma, People’s Republic of China. D192 674.19 A Polydeoxynucleotide Derived Drug Defibrotide Inhibits Nucleosome Generation in Whole Blood. Implications in the Management of VOD. J. Fareed, D. Hoppensteadt, A. Walborn, T. Phan, S. Spatz, J. Walenga, W. Jeske. Loyola University Chicago. D193 674.20 Genetic Variation in 12-Lox Regulates the Efficacy Of ω-3 and ω-6 Fatty Acids to Suppress Platelet Activation. S. Shil, M. Hawley, C. Li, M. Holinstat. University of Michigan. D194 674.21 Novel Antiplatelet Role for a Protein Disulfide Isomerase-Targeted Peptide: Evidence of Covalent Binding to C-Terminal CGHC Redox Motif. R.S. Gaspar, H.R. Sousa, E. Sena, S.A. Da Silva, J. ‘de Lima Fontelles, T. Araujo, D. Fries, A. Azevedo-Santos, F. Laurindo, A. Trostchansky, A. Paes. Federal University of Maranhão, Brazil, University of Sao Paulo, Brazil and University of the Republic, Uruguay.
SUNDAY PHARMACOLOGY
675. CLINICAL PHARMACOLOGY I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Translational and Clinical Pharmacology Presentation time: 12:30 pm–2:30 pm D195 675.1 Identification of a Novel MetforminMethylglyoxal Imidazolinone Metabolite in T2DM Patients and Its Potential Roles in Alleviating T2DM Complications. T.L. Hargraves, O.R. Kinsky, T.J. Monks, S.S. Lau. Wayne State University and University of Arizona. D196 675.2 12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor. B. Tourdot, Z. Isingizwe, R. Adili, T. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. D197 675.3 Histone Modification Is a Novel Epigenetic Mechanism to Up-Regulate Human Blood-Brain Barrier Transporters. D. You, X. Wen, A. Morris, J.R. Richardson, L.M. Aleksunes. Rutgers University and Northeast Ohio Medical University. D198 675.4 Novel Characterization of Docohexanoic Acid and Its 12-LOX Products, 11-HDHE and 14-HDHE on Human Blood Platelets. D.D. Craven, N. Edokobi, M. Hawley, T. Holman, M. Holinstat. University of Michigan Medical School and University of California- Santa Cruz. D199 675.5 11/14-Oxy-DPA, the 12-LOX Derived Metabolites of DPA, Inhibit Platelet Activation Through the cGMP-PKG Signaling Pathway. J. Yeung, N. Edokobi, M. Hawley, D. Craven, C. Li, T.R. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. D200 675.6 Prostaglandin E2 (PGE2) Levels as a Predictor of Type 2 Diabetes Control in Human Subjects: A Cross-Sectional View of Initial Cohort Study Data. R. Fenske, A. Weeks, A. Brill, R. Nall, S. Pabitch, M. Punt, M. Daniels, S. Blaha, D.B. Davis, M. Kimple. University of Wisconsin—Madison. D201 675.7 Effect of Sevoflurane Plus Ondansetron and Ranitidine vs. Propofol and Remifentanil for the Prevention of Post-Operative Nausea and Vomiting. S.M. Lynch, O.L. Tulp, G.P. Einstein. USAT Montserrat, Montserrat. D202 675.8 Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study. J. Tank, K. Heusser, O. Holz, M. May, J. Brinkmann, A. Diedrich, T. Framke, A. Koch, A. Grosshennig, F.C. Sweep, W. Koch, N. Krug, J. Jordan, J. Hohlfeld. Institute for Clinical Pharmacology, Hannover Medical School, Germany, Fraunhofer Institute for Toxicology and Experimental Medicine, Germany, Hannover Medical School, Germany, Vanderbilt University School of Medicine and Radboud University Medical Center, Netherlands.
676. CARDIOVASCULAR PRECLINICAL PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Translational and Clinical Pharmacology Presentation time: 12:30 pm–2:30 pm D203 676.1 Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)-Epicatechin on Cardiometabolic Endpoints. F. Villarreal, A. Moreno-Ulloa, T. Ciaraldi, B. Best, I. Ramirez-Sanchez, G. Ceballos, S. Dugar, G. Schreiner, R. Henry. UCSD School of Medicine, UCSD School of Pharmacy, IPN ESM, Mexico and Cardero Therapeutics Inc. D204 676.2 Treatment with the Soluble Guanylate Cyclase Stimulator IW-1973 Reduces N-Terminal Pro B-Type Natriuretic Peptide and Improves Heart Function in Rat Models of Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction. C. Shea, G. Liu, R. Sarno, E. Lonie, D. Zimmer, M. Currie, J. Masferrer. Ironwood Pharmaceuticals. D205 676.3 Pretreatment with Probenecid Downregulates Kidney Pendrin Expression and Potentiates Hydrochlorothiazde Diuresis in Rat. S. Barone, J. Xu, K. Zahedi, M. Soleimani. University of Cincinnati, Research Services and VA Hospital. D206 676.4 Switching Off TRPC6 Signaling: A New AntiEdemagenic Strategy. M. Amin, H. Piplani, T. Sharma, D. Mehta. University of Illinois at Chicago. D207 676.5 ATP-Sensitive K+ Channels in Smooth Muscle Cells from Rat Mesenteric Lymph Vessels. B.R. Garner, A.J. Stolarz, T.W. Fletcher, N.J. Rusch. University of Arkansas for Medical Sciences. D208 676.6 The Fungicidal Potential of Dimethyloxaglycine (DMOG) in Infected Bone Marrow Macrophages of C57 BL6-J Mice. A. Lopez, W. Buesing, J. Tweedle, G. Deep. University of Puerto Rico at Ponce and University of Cincinnati College of Medicine.
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Physiology 677. ATHEROSCLEROSIS/THROMBOSIS/PLATELETS Poster (Sponsored by: The Microcirculatory Society)
Poster
Sun. 9:00 am—McCormick Place Convention Center, Hall F
(Sponsored by: The Microcirculatory Society)
Presentation time: 12:45 pm–3:00 pm E157 677.1 Tetramethylpyrazine Reduces Intra-Platelet Calcium via Suppressing the SGK1/STIM1/Orai1 Pathway. Z. Wang, H. Cang, S. Gao, L. Han, H. Wu. Second Affiliated Hospital, Henan University of Traditional Chinese Medicine, People’s Republic of China. E158 677.2 YiqiHuoxue Decoction and Its Constituents Inhibit the Activation of Platelets and Thrombosis for the Prevention and Treatment of Cardiovascular Diseases. H. Wu, Z. Lei, S. Gao, L. Han. Henan University of Traditional Chinese Medicine, People’s Republic of China. E159 677.3 Effects of GLA Precursors Added to Atherogenic Diet on Platelet Insulin Sensitivity, Plasminogen Activator Activity and Atherogenic Plaque Development in Rabbits. E.L. Beard, S. Edupuganti. Loyola University. E160 677.4 Functional Analyses of Reticulated Platelets. M. Hayman, P. Armstrong, M. Chan, T. Warner. William Harvey Research Institute, United Kingdom. E161 677.5 Vascular Activation and Development of Carotid Intima-Media Thickness in Postmenopausal Women Is Influenced by Pregnancy History. V.M. Miller, V.D. Garovic, M.M. Mielke, K.R. Bailey, B. Lahr, W.M. White, M. Jayachandran. Mayo Clinic. E162 677.6 Fibrinogen and Its Soluble Fibrin as Mediators of Erythrocyte Aggregation. S. WeberFishkin, R.A. Clark, D. Galanakis, B.A. Irizarry, A.L. Young, M.(. Frame. Stony Brook University. E163 677.7 The Effects of Membrane Cholesterol on the Mechanics of Vascular Smooth Muscle Cell. Z. Hong, J. Childs, H. Sanyour. University of South Dakota. E164 677.8 Substrate Properties Affect Thrombin Generation Kinetics. S. Laljee, D.A. Rubenstein, W. Yin. Stony Brook University. E165 677.9 Platelet Functional Effects Induced by Fluorescent Labeling via Transgenic- and Antibody-Based Approaches. Q. Da, R. Rumbaut. Michael E. DeBakey VA Medical Center and Baylor College of Medicine. E166 677.10 Circulating Mitochondrial (mt) DNA Fragments as Precursors of Inflammation in Early Stages of Atherogenesis. M.V. Ruchko, V.M. Pastukh, S. Sukhanov, O.M. Gorodnya, S.D. Danchuk, M.N. Gillespie. University of South Alabama College of Medicine and University of Missouri School of Medicine. E167 677.11 Apoptosis and Autophagy in Human Vein Grafts Replacing Occluded Coronary Arteries in Atherosclerosis. H.E. Bortier, M. Kockx, G. De Meyer. University of Antwerp, Belgium and AZ Middelheim, Belgium.
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678. ANGIOGENESIS/MICROVASCULAR REMODELLING/INJURY AND REPAIR
Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E168 678.1 Activator of G-Protein Signaling 8 Is Involved in VEGF-Induced Choroidal Angiogenesis. H. Hayashi, A.A. Mamun, M. Sakima, M. Takeyama, R. Yagasaki, M. Zako, T. Nakahara, M. Sato. Aichi Medical University, Japan and Kitasato University School of Pharmaceutical Sciences, Japan. E169 678.2 Recovery of Vasomotor Control in Microvascular Resistance Networks of Regenerating Skeletal Muscle. C.A. Fernando, D.W. Cornelison, S.S. Segal. University of Missouri. E170 678.3 Exercise Recovers Loss of Microvessel Density due to Lowered Nitric Oxide Bioavailability. K. Branyan, M. Ashman, C. Pitzer, P. Chantler, M. Olfert. West Virginia University. E171 678.4 Mechanoadaptation, Arteriogenesis, and Vascular Reactivity in Male and Female C57Bl/6 Mice. T.R. Cardinal, L.L. Burckhardt, M.T. Chu, A.M. Krall, R.R. Gallagher, A.J. Bynum. Cal Poly. E172 678.5 Absence of Endothelial Estrogen Receptor Alpha Decreases Stiffness and Induces Outward Hypertrophic Remodeling in the Resistance Arteries of Male Mice Fed a Western Diet. F.I. Ramirez-Perez, C. Manrique-Acevedo, J. Padilla, V.J. Vieira-Potter, A.R. Annaya, B.J. Barron, D. Chen, D. Haertling, C. Declue, J.R. Sowers, L.A. Martinez-Lemus. University of Missouri. E173 678.6 The Role of Leptin in Coronary Collateral Growth. K. Graham, V. Ohanyan, M. Enrick, C. Kolz, W.M. Chilian, L. Yin. Northeast Ohio Medical University. E174 678.7 TRPV4 Channels Regulate Vascular Integrity Through Stabilization of VE-Cadherin Junctions. H.C. Cappelli, V. Amin, P. Sharma, A.K. Kanugula, R.K. Adapala, J. Meszaros, S.K. Paruchuri, C.K. Thodeti. Northeast Ohio Medical University (NEOMED) and University of Akron. E175 678.8 Development of the ex Vivo Mouse Mesometrium Model to Investigate Multicellular Dynamics During Angiogenesis. A.D. Suarez-Martinez, D. Kaplan, K. Huang, S. Meadows, S. Bierschenk, M. Sperandio, W.L. Murfee. Tulane University and Ludwig-Maximilians Universität, Germany. E176 678.9 Microvascular Content and Insulin Sensitivity Within Skeletal Muscle and Adipose Tissue Differs Between Male and Female Mice on a High-Fat Diet. G. Abdifarkoosh, M. Rudnicki, E. Roudier, T.L. Haas. York University, Canada. E177 678.10 Microfluidic Model of Angiogenic Remodeling at Blood Vessel Bifurcations. E. Akbari, G.B. Spychalski, K.K. Rangharajan, S. Prakash, J.W. Song. The Ohio State University. E178 678.11 Interleukin-10 (IL-10) Enhances Wound Healing of Cutaneous Flaps Following Ischemia Reperfusion Injury (IRI). Y. Tang, T. Lian. LSU Health Science Center.
SUNDAY PHYSIOLOGY E179 678.12 Endothelial Foxo1 and Foxo3a Synergistically Repress Skeletal Muscle Vascular Growth and Blood Flow Recovery in a Mouse Model of Hind Limb Ischemia. E. Nwadozi, M. DeCiantis, T. Haas. York University, Canada. E180 678.13 Evaluation of Sex Differences in Vascular Density in a Rodent Model of Traumatic Brain Injury Using Steady-State Contrast Enhanced Magnetic Resonance Imaging. J.N. Mayo, D. Wright, R. Phillips, T. O’Brien, S. Shultz. Western State Colorado University and University of Melbourne, Australia. E181 678.14 Phenotypic Sexual Dimorphism of Micro- And Macrovascular Endothelium with Respect to Size, Growth, and Wound Repair. V.H. Huxley, S. Sieveking, S. Kemp, C. Schramm. University of Missouri—Columbia.
679. INFLAMMATION/LEUKOCYTEENDOTHELIUM INTERACTIONS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E182 679.1 Neutrophil Extracellular Traps Contribute to Endothelial Barrier Dysfunction During Sepsis. J.E. Meegan, R.S. Beard; Jr, X. Yang, J.J. Reynolds, D.C. Coleman, M. Jannaway, S.Y. Yuan. University of South Florida. E183 679.2 Super Resolution Imaging Visualized the Nanoscaled Localization of Integrin Activation During Human Neutrophil Arrest. Z. Fan, W.B. Kiosses, K. Ley. La Jolla Insititue for Allergy and Immunology, The Scripps Research Institute and University of California San Diego. E184 679.3 Endothelial Mineralocorticoid Receptors Contribute to Sex-Dependent Vascular Inflammation and Plaque Vulnerability in Atherosclerosis. M. Moss, S. Iyer, D. Engelbertsen, V. Serbulea, A.H. Lichtman, N. Leitinger, I.Z. Jaffe. Tufts Medical Center, Brigham and Women’s Hospital and University of Virginia School of Medicine. E185 679.4 Pro-Inflammatory Cytokines and the Marrow Microenvironment. S. Lee, R. Prisby. University of Texas Arlington. E186 679.5 Chlorinated Lipids Elicit Neutrophil-Endothelial Interactions in Mesenteric Microcirculation. H. Yu, M. Wang, D.Z. Wang, T. Kalogeris, D.A. Ford, K.J. Ronald. University of Missouri and Saint Louis University. E187 679.6 Prunella vulgaris Attenuates Diabetic Renal Injury by Suppressing High Glucose-Induced Mesangial Fibrosis and Inflammation. S. Namgung, J. Yoon, B. Han, E. Choi, M. Hong, Y. Lee, D. Kang, H. Lee. Wonkwang University, Republic of Korea. E188 679.7 Endothelial Cell Barrier Protein Expression Differs by Organ and Sex. S.S. Kemp, V.H. Huxley, C. Schramm, S.W. Sieveking. University of Missouri. E189 679.8 IGF-1 Receptor on Leukocytes Potentiates Western Diet-Induced Inflammatory Response and Progression of Atherosclerosis in ApoE-Deficient Mice. M. Wang, Y. Higashi, D. Wang, H. Yu, P. Delafontaine, R. Korthuis. University of Missouri.
E190 679.9 Oncostatin M Induces Barrier Dysfunction in Human Brain Microvascular Endothelium via SnailDependent Repression of TAMPs. T.S. Wertz, B.A. Hoettels, K. Tawara, J.T. Oxford, C.L. Jorcyk, R.S. Beard Jr. B o i s e State University.
680. ISCHEMIA-REPERFUSION/FREE RADICAL BIOLOGY Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E191 680.1 Increased Cysteine Sulfonation of Complex I, Complex III, and Aconitase Is Associated with Mitochondrial Dysfunction in the Post-Ischemic Heart. P.T. Kang, C. Chen, P. Lin, L. Zhang, Y. Chen. Northeast Ohio Medical University and The Ohio State University. E192 680.2 Endothelium Protects Smooth Muscle from Oxidative Stress in Skeletal Muscle Resistance Arteries. S.Y. Sinkler, S.S. Segal. University of Missouri. E193 680.3 Angiotensin II-Preconditioning Is Associated with Increased PKCε/PKCδ Ratio and Prosurvival Kinases in Mitochondria. R. Nuñez, S. Javadov, N. Escobales. University of Puerto Rico School of Medicine. E194 680.4 Interleukin-12 Disruption Protects Myocardium from Ischemia-Reperfusion Injury in Type 2 Diabetic Mice. V. Mali, W. Tennant, S. Haddox, K. Matrougui, S. Belmadani. Department of Physiology and Eastern Virginia Medical School. E195 680.5 Cathepsin B Mediated Degradation of Jejunal Epithelial Tight Junction Proteins During the Early Stage of Hemorrhagic Shock. N.P. Klein, A. Courelli, G. SchmidSchoenbein. University of California San Diego and HammLippstadt University of Applied Sciences, Germany. E196 680.6 Chloropalmitate Increases Solute Permeability and VE-Cadherin Internalization in Human Microvascular Endothelial Cells. T. Kalogeris, T.M. Birkhead, D. Ford, R. Korthuis. University of Missouri and Saint Louis University. E197 680.7 Cardioprotective Effects of Hydroalcoholic Extract of Terminalia Capatta in Isolated Perfused Rat Hearts. J.D. Torres-Tirado, G. Pérez, E. Sanchez, A. Estrada, A. Zacarias, A. Leon. Universidad Autonoma de San Luis Potosí, Mexico.
681. MICROVASCULAR CELL SIGNALLING PATHWAYS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E198 681.1 Capillary Endothelial Gq Protein-Coupled Receptors and PIP2 Toggle Signaling Between TRPV4 and Kir2 Channels in the Brain. O.F. Harraz, T.A. Longden, F. Dabertrand, M.T. Nelson. University of Vermont.
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PHYSIOLOGY SUNDAY E199 681.2 Increased Propensity for Cerebral Microhemorrhages in a IGF-1 Deficient Mouse Model of Accelerated Vascular Aging. S. Tarantini, M. ValcarcelAres, A. Yabluchanskiy, Z. Springo, G. Fulop, N. Ashpole, T. Gautam, C. Giles, J. Wren, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center— Reynolds Oklahoma Center on Aging Research, University of Mississippi and Oklahoma Medical Research Foundation. E200 681.3 Treatment with the Mitochondrial Antioxidant Peptide SS-31 Rescues Neurovascular Coupling Responses and Cerebrovascular Endothelial Function and Improves Cognition in Aged Mice. S. Tarantini, M. Valcarcel-Ares, A. Yabluchanskiy, G. Fulop, P. Hertelendy, T. Gautam, E. Farkas, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research and University of Szeged, Hungary. E201 681.4 Neurovascular Uncoupling Predicts Cognitive Decline and Gait Abnormalities in a Clinically Relevant Mouse Model of Whole Brain Irradiation. A. Yabluchanskiy, S. Tarantini, P. Hertelendy, M. Valcarcel-Ares, T. Gautam, E. Farkas, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research and University of Szeged, Hungary. E202 681.5 Interaction of Obesity and Nrf2 Deficiency Accelerates Cerebromicrovascular Aging and Impairs Neurovascular Coupling Responses. M.N. Valcarcel-Ares, S. Tarantini, P. Hertelendy, Z. Tucsek, T. Gautam, T. Kiss, R. De Cabo, E. Farkas, Kinter, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research, NIA, University of Szeged, Hungary and Oklahoma Medical Reseach Foundation. E203 681.6 Administration of Prostacyclin Mediates Cutaneous Vasodilation But Not Sweating in Young and Older Females: Roles for Nitric Oxide and KCa Channels. N. Fujii, B.D. McNeely, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan. E204 681.7 Endothelial Mitochondria Regulates Local Calcium Signalling in Mesenteric Arteries from Mice. F. Toussaint, D. Béziau, C. Charbel, A. Blanchette, G. Mayer, P. Comtois, J. Ledoux. Montreal Heart Institute, Canada and Université de Montréal, Canada. E205 681.8 Spatio-Temporal Analysis of Intracellular and Intercellular Calcium Signaling in Microvascular Endothelial Cell Tubes. M.J. Socha, E. Billings, T.L. Domeier, R.S. Balaban, S.S. Segal. The University of Scranton, National Institutes of Health, University of Missouri-Columbia and Dalton Cardiovascular Research Center. E206 681.9 Smooth Muscle α1-Adrenergic Receptor Activation Initiates a Negative Feedback Mechanism That Involves Ca2+ Influx Through Endothelial TRPV4 Channels. K. Hong, E.L. Cope, Marziano, S.K. Sonkusare. University of Virginia. E207 681.10 Signal Inference: A Method to Locate and Track Calcium Waves with Statistical Confidence. E. Billings, M.J. Socha, T.L. Domeier, R.S. Balaban, S.S. Segal. National Institutes of Health, The University of Scranton, University of Missouri-Columbia and Dalton Cardiovascular Research Center. E208 681.11 Essential Role for Interleukin-12 in Microvascular Endothelial Dysfunction in Type 2 Diabetes. E. Radwan, V. Mali, S. Haddox, M. Trebak, S. Belmadani, K. Matrougui. EVMS, Assiut University, Egypt and Penn State.
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E209 681.12 Calreticulin Localized to the Myoendothelial Junction Mediates Heterocellular Communication in Resistance Arteries. L.A. Biwer, M.E. Good, K. Hong, R. Patel, N. Agrawal, R. Looft-Wilson, S. Sonkusare, B.E. Isakson. University of Virginia and College of William and Mary. E210 681.13 Contractile Function of Coronary Arterioles Is Impaired in Adiponectin-Deficient Mice. J. Bramy, K. Gorman, M. Delp, P. Ghosh, K. Hotta, B. Behnke, J. Delp. Florida State University and Kansas State University.
682. TISSUE MICROVESSEL INTERACTIONS/ EXTRACELLULAR MATRIX Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E211 682.1 Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces. J. Dale, L. Krishnan, K. Aliaj, J. Beare, J. Weiss, J. Hoying. Cardiovascular Innovation Institute and University of Utah. E212 682.2 Impact of Endothelial-Specific FoxO1 Depletion on the Development of Metabolic Dysfunction in Obesity. M. Rudnicki, G. Abdifarkosh, E. Roudier, E. Nwadozi, T. Haas. York University, Canada. E213 682.3 ‘Fibulin-4 Is Important for Maintaining Vascular Wall Integrity in Large but Not Small Vessels. C.M. Halabi, M. Lin, T.J. Broekelmann, M. Chu, R.P. Mecham. Washington University School of Medicine and Thomas Jefferson University. E214 682.4 The Extracellular Matrix Proteoglycan Decorin Is Upregulated by Endothelial Cells During Inflammation and Contributes to Blood-Brain Barrier Dysfunction. B.A. Hoettels, T.S. Wertz, D.E. Birk, J.T. Oxford, R.S. Beard Jr. B o i s e State University and University of South Florida.
683. LYMPHATIC AND VENULAR FUNCTION Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E215 683.1 Lymphatic Vessel-Independent Lymph Flow Pattern from the Peri-Nodal Adipose Tissue to the Lymph Node. Y. Lin, S. Liao. University of Calgary, Canada. E216 683.2 Alterations to Venular Function in Skeletal Muscle with Metabolic Syndrome. K. Lemaster, Z. Farid, D. Jackson, D. Goldman, R. Brock, J. Frisbee. University of Western Ontario, Canada and West Virginia University. E217 683.3 Adipose Tissue VEGF-D Overexpression Increases Lymphatic Vessel Density and Protects Against Inflammation and Insulin Resistance in Obesity. G.M. Lammoglia, S.E. Barajas, A.J. Reyna, J.M. Rutkowski. Texas A&M College of Medicine.
SUNDAY PHYSIOLOGY E218 683.4 Anti-Ascites Adaptation of Liver to Sinusoidal Hypertension. R.M. Dongaonkar, G.A. Laine, C.M. Quick, R.H. Stewart. Texas A&M University. E219 683.5 Ileal Smooth Muscle Thickness Is Greater in Young Obese Zucker Rats. A.R. Burgess, A.N. Trujillo, M. Barter, J.W. Breslin. University of South Florida. E220 683.6 Thoracic Duct Lymph Suppresses the Release of Inflammatory Mediators from Macrophages in Vitro. R. Castillo, L. Hodge. University of North Texas Health Science Center.
684. MICROCIRCULATION Poster (Sponsored by: APS Cardiovascular Section) (Cosponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E221 684.1 Ginsenoside Rb1 Protects Against Ischemia/ Reperfusion-Induced Myocardial Injury via Energy Metabolism Regulation Mediated by RhoA Signaling Pathway. J. Han, Y. Cui, C. Pan, L. Yan, B. Hu, X. Chang, Y. Liu, K. Sun, Q. Li, J. Fan. Peking University Health Science Center, People’s Republic of China. E222 684.2 Vasodilatory Function in Human Skeletal Muscle Arteries with Advancing Age: Role of Adropin. O. Kwon, R. Andtbacka, J. Hyngstrom, R. Richardson. University of Utah. E223 684.3 Enhanced Myogenic Response of Cerebral Arteries Induced by Pre-Existing Hypertension Is Intact After Traumatic Brain Injury. N. Szarka, K. Amrein, E. Czeiter, A. Buki, A. Koller, P.J. Toth. University of Pecs, Hungary and University of Physical Education, Hungary. E224 684.4 Arteriolar Vasodilation Involves Actin Depolymerization. P.S. Clifford, B.S. Ferguson, J.L. Jasperse, M.A. Hill. University of Illinois Chicago, University of Missouri and Pepperdine University. E225 684.5 Influence of Ischaemia-Reperfusion Injury on Sensory Nerve Control of Vasodilation During a Subsequent Bout of Local Skin Heating in the Forearm. G.W. McGarr, G.J. Hodges, S.S. Cheung. Brock University, Canada. E226 684.6 Angiotensin II-Mediated Vasoconstriction of the Visceral Adipose Tissue Vasculature Is Linked to Systemic Hypertension in Obesity. s. Park, S. Karki, S.M. Saggese, M.A. Zuriaga, B. Carmine, D. Hess, C. Apovian, N. Gokce. Boston University School of Medicine. E227 684.7 Phenotypic and Sex Differences in Microvesicles Released from Cultured Human Brain Microvascular Endothelial Cells in Response to Proinflammatory and Prothrombotic Stimuli. L.W. Hunter, M. Jayachandran, V.M. Miller. Mayo Clinic. E228 684.8 Characterization of TRPV1 and TRPV2 Channel Expression and Vasomotor Function in Human Arterioles. A.M. Korishettar, Y. Nishijima, S. Cao, D. Zhang. Medical College of Wisconsin.
E229 684.9 Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple Comorbidities. J. van de Wouw, O. Sorop, R.W. van Drie, D. Merkus, D.J. Duncker. E230 684.10 Polyethylene Glycol Camouflaged Earthworm Hemoglobin. P. Cabrales, V. Jani. Bioengineering—UCSD. E231 684.11 Effect of Acute Increases in Retrograde Shear on Near-Infrared Spectroscopy Derived Microvascular Reactivity. M. Ramos, C.D. Black, P.A. Branch, J.T. Caldwell, G.C. Wardlow, C.J. Ade. University of Oklahoma and Kansas State University. E232 684.12 Influence of Ischaemia-Reperfusion Injury on the Subsequent Response to Local Heating in Non-Glabrous and Glabrous Skin of the Index Finger. G.W. McGarr, G.J. Hodges, S.S. Cheung. Brock University, Canada. E233 684.13 Effect of Noradrenergic Blockade on LowFrequency Oscillations of Human Skin Microcirculation. A.T. Del Pozzi, M.M. Mallette, Z.T. Martin, G.J. Hodges. Ball State University and Brock University, Canada. E234 684.14 Human Skeletal Muscle Feed Artery Function: Role of the Advanced Glycation End-Products Receptor (RAGE). S. Park, O. Kwon, R.H. Andtbacka, J.R. Hyngstrom, R.S. Richardson. University of Utah, George E. Whalen VA Medical Center, Huntsman Cancer Hospital and University of Utah. E235 684.15 Direct Implications for Caveolin-1 in TRPV1 Mediated NO Production: Elucidating a Mechanism of Vasoreactivity. J.N. Fahmy, S. Andrei, D.J. DelloStritto, W. Geldenhuys, D.S. Damron, I.N. Bratz. Northeast Ohio Medical University, Kent State University and West Virginia University. E236 684.16 Contribution of Adiponectin to Vascular Responses in Bone Resistance Arteries in Mice. P. Ghosh, K. Hotta, T. Lucero, K. Borodunovich, M. Cowan, J. Bramy, B. Behnke, M. Delp, J. Delp. Florida State University and Kansas State University. E237 684.17 Contribution of kV7 Channels to AcetylcholineInduced Dilation in Human Adipose Arterioles. Y. Nishijima, D. Zhang. Medical College of Wisconsin. E238 684.18 Pharmacological or Genetic Interruption of Focal Adhesion Kinase Improves Endothelial Barrier Dysfunction Resulting from Ischemia/Reperfusion Injury. R.J. Haines, S. Zhang, R.A. Eitnier, F. Wang, C.G. Yang, M.H. Wu. University of South Florida and Morsani College of Medicine. E239 684.19 The Role of Formyl Peptide Receptors (FPRs) in Cerebral Microvascular Dysfunction in Sickle Cell Disease. F.N. Gavins, J. Ansari, E.Y. Senchenkova, S.A. Vital. LSU Health Sciences Center. E240 684.20 A Mathematical Model of Cerebral Blood Flow Control: Role of Kir Channels. A. Moshkforoush, T. Longden, F. Dabertrand, M. Nelson, N. Tsoukias. Florida International University and University of Vermont. E241 684.21 Prolonged Sitting Results in Microvascular, but Not Macrovascular, Dysfunction in Healthy Young Women. J.R. Vranish, B.E. Young, J. Kaur, J.C. Patik, J. Padilla, P.J. Fadel. University of Texas at Arlington and University of Missouri.
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685. INSTRUMENTATION, METHODOLOGY, AND EXPERIMENTAL MODELS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E242 685.1 Assessment of Cutaneous Microcirculation Autoregulation with Phase and Linear Based Eulerian Video Magnification. M. Golden, J. Smith, D. Oswald, C. Haselby, R. Murphy, K.P. Heinking, K.K. Henderson. Midwestern University. E243 685.2 An Ischemia Model on a Chip. W. Yin, L. Abejar, D.A. Rubenstein, M.D. Frame. Stony Brook University. E244 685.3 CRISPR/Cas9 Creation of a Mouse Lacking a Unique Motif on Alpha Globin Demonstrates Its Critical Role in Regulating Nitric Oxide in Vivo. G.B. Broseghini Filho, J.T. Butcher, S.T. Keller, S. Poonam, H. Kwangseok, L.J. DeLalio, X. Wenhao, A.S. Padilha, L. Columbus, S. Sonkusare, B.E. Isakson. Federal University of Espirito Santo, Brazil and University of Virginia. E245 685.4 Adipose Tissue–Skeletal Muscle Crosstalk: Obese Human Subcutaneous and Visceral Adipose Tissues Both Supress Muscle Insulin Signalling in Men and Women. O. Sarr, R.J. Strohm, T.L. MacDonald, J.K. Reed, J. FouteNelong, D.J. Dyck, D.M. Mutch. University of Guelph, Canada and Guelph General Hospital, Canada. E246 685.5 Novel Approaches to Manipulate Gene Expression in the Mouse Kidney: siRNA Silencing and Gene Rescue. L.D. Asico, P. Konkalmatt, V.M. Villar, X. Wang, I. Armando, H. Lin, P.A. Jose. The George Washington University School of Medicine and Health Sciences. E247 685.6 Maintenance of Nerves in the Rat Mesentery Culture Model. N. Hodges. Tulane University. E248 685.7 Partitioning Resistance to Plasma Fluid Within Endothelial Glycocalyx. F.E. Curry. University of California, Davis.
686. CARDIAC ELECTROPHYSIOLOGY
687. HEART FAILURE Poster (Sponsored by: APS Cardiovascular Section)
Poster
Sun. 9:00 am—McCormick Place Convention Center, Hall F
(Sponsored by: APS Cardiovascular Section)
Presentation time: 12:45 pm–3:00 pm
Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E249 686.1 Glucocorticoids Modulate Kvβ1 Dependent Cardiac Function Through Potassium Channel (Kv) Activity. J. Tur, S.L. Badole, K.C. Chapalamadagu, S.M. Tipparaju. University of South Florida. E250 686.2 Heart-Rate Corrected QT Interval Prolongation in Impaired Fasting Glucose and Type 2 Diabetes: The Polish Norwegian Study (PONS). G. Vaidean, S. Vansal, M. Manczuk, J. Williams.
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E251 686.3 LITAF, a Novel Regulator of Cardiac Excitation. K.S. Moshal, K. Roder, A.A. Werdich, N.T. Dural, T. Kim, L.L. Cooper, Y. Lu, B. Choi, D. Terentyev, C. MacRae, G. Koren. Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brigham and Womens Hospital and Gazi University, Turkey. E252 686.4 Effects of Ryanodine on Electrical Activity of Cells with Slowest dV/dtmax in Newborn and Adult Mice Sinoatrial Node. M. Gonotkov, V. Golovko. Institute of Physiology, Komi Science Center, The Urals Branch of the Russian Academy of Sciences and Russian Federation. E253 686.5 Sex Differences in Hypertension Development Strategy: A Role of LF HRV Power. V.E. Shekh. V. N. Karazin Kharkiv National University, Ukraine. E254 686.6 Exercise Training Fails to Protect Against Development of Ischemia-Induced Ventricular Fibrillation in Isolated Rat Hearts. H. Clements-Jewery, P. Radich, N. Rawson, A.S. Hatcher. University of Illinois College of Medicine at Rockford and West Virginia School of Osteopathic Medicine. E255 686.7 The Contribution Na-Current in Generating of Upstroke Action Potential in the Cells of Sinoauricular Region of Mouse, Guinea Pig, Rabbit and Pig. E. Lebedeva, V. Golovko. Institute of Physiology, Komi Science Centre and the Ural’s Branch of the Russian Academy of Sciences, Russian Federation. E256 686.8 Second Hand Smoke Exposure Increases Susceptibility to Arrhythmogenic Cardiac Alternans. Z. Wang, L. Wang, K.E. Pinkerton, C. Chen, C.M. Ripplinger. University of California, Davis. E257 686.9 Functional Microdomain in the Cardiac Pacemaking in Mouse. D. Lang, A. Warden, T. Kamp, A. Glukhov. University of Wisconsin-Madison. E258 686.10 Extracting Noise from Electrocardiograms in Real-Time to Predict the Onset of Cardiac Arrest. J.M. Aboulhosn, S. Sindi, R.M. Ortiz. University of California at Merced.
E259 687.1 N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats with Persistent Pressure Overload. D.R. Abreu Reyes, C.R. Moreno, M.J. Gomes, L.U. Pagan, R.L. Damatto, F.C. Damatto, I.C. Depra, A.A H. Fernandes, K. Okoshi, M.P. Okoshi. Botucatu Medical School, Sao Paulo State Universit, Brazil, Botucatu Medical School, Sao Paulo State University, UNESP, Brazil, Botucatu Medical School, Sao Paulo State University and UNESP, Brazil. E260 687.2 Changes in Plasma β-Adrenergic Receptor Kinase-1 Following Left Ventricular Assist Device Placement. Q. Denfeld, C.S. Lee, W.R. Woodward, B.A. Habecker. Oregon Health & Science University Knight Cardiovascular Institute and Oregon Health & Science University.
SUNDAY PHYSIOLOGY E261 687.3 Alterations in the Balance of Cardiomyocyte Glucocorticoid and Mineralocorticoid Receptor Signaling Lead to Heart Failure. R. Oakley, D. Cruz-Topete, B. He, J. Foley, P. Myers, E. Murphy, P. Chambon, M. Willis, J. Cidlowski. NIEHS/NIH, NHLBI/NIH, IGBMC, France and McAllister Heart Institute. E262 687.4 Glucocorticoid Receptor Signaling Is Critical for microRNA Gender-Specific Regulation of Gene Expression in the Adult Mouse Heart. D. Cruz-Topete, R.H. Oakley, X. Xu, J.A. Cidlowski. NIEHS/NIH and LSU Health Science Center-Shreveport. E263 687.5 The Sphingosine-1-Phosphate Analog, FTY720, Reverses Diastolic Dysfunction and Hypertrophy in Familial Hypertrophic Cardiomyopathy. D.M. Ryba, C.M. Warren, C.N. Karam, R.T. Davis; 3rd, S.A. Chowdhury, M.G. Alvarez, D.F. Wieczorek, R. Solaro, B.M. Wolska. University of Illinois at Chicago, University of Cincinnati and University of Illinois at Chicago. E264 687.6 Impact of HFpEF on the Development of Neuromuscular Fatigue During Exercise. J.C. Weavil, T.S. Thurston, T.J. Hureau, J.R. Gifford, A.D. Bledsoe, J.N. Nativi, R.S. Richardson, M. Amann. University of Utah. E265 687.7 Intracoronary Gene Therapy with AdvCRTC2 Improves LV Dysfunction After Pressure Load Hypertrophy. M.L. Tay, N.C. Lai, D. Giamouridis, E. Tang, T. Tang, W. Lew. VMRF and University of Chicago. E266 687.8 Would Healing Was Improved in Mice After Myocardial Infarction by Nature Naphthoquinone Shikonin. A. Cai, D. Bedja, Z. Cai. CL Laboratory and LLC. E267 687.9 α1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle. P.M. Cowley, G. Wang, P.M. Swigart, D.H. Lovett, P.C. Simpson, A.J. Baker. University of California, San Francisco, VA Medical Center SF. E268 687.10 Heterozygous Deletion of Mediator Subunit 1 Causes Heart Failure in Mice. K. Spitler, C. Grueter. University of Iowa. E269 687.11 Aortic-Banding and Ovariectomy Independently Promote Coronary Artery Stiffness and Structural Remodeling. A. Ouyang, J. Hiemstra, T. Olver, J.C. Edwards, J.R. Ivey, P.K. Thorne, C.A. Emter, B.S. Fleenor. University of Kentucky and University of Missouri-Columbia. E270 687.12 Exercise Training Augments Neuronal Nitric Oxide Synthase Dimerization in the Paraventricular Nucleus of Rats with Heart Failure. N. Sharma, X. Liu, T. Llewellyn, K.P. Patel. University of Nebraska Medical Center. E271 687.13 Urocortin-3 Gene Transfer Increases Function of the Failing Heart in Mice. D. Giamouridis, N.C. Lai, M. Gao, M. Blankesteijn, E. Biessen, H.K. Hammond. Maastricht University, Netherlands, Veterans Medical Research Foundation and UC San Diego. E272 687.14 Ipragliflozin Prevents the Worsening of Ischemic Heart Failure in Diabetic Rats Independent of Its Diuretic Effect. K. Kamada, K. Saku, T. Kishi, T. Akashi, T. Takehara, H. Tsutsui, K. Sunagawa. E273 687.15 Multiple Co-Morbidities Have Detrimental Effects on Myocardial Function and Perfusion in a Large Animal Model of Diastolic Dysfunction. O. Sorop, J. van de Wouw, R.W. van Drie, I. Heinonen, V.J. de Beer, A.H. van den Meiracker, J. van der Velden, J.A. Joles, D. Merkus, D.J. Duncker. Erasmus MC, Netherlands, University of Turku, Finland, VU University Medical Center, Netherlands and UMC Utrecht, Netherlands.
E274 687.16 How Does the Overexpression of DGKζ Can Improve the Survival and Rescue the Heart Failure Associated Loss of Contractility? N. Aslam. BioSystOmics. E275 687.17 Reinstallation of Glucocorticoid Receptor (GR) in the Heart Rescues Left Ventricular Systolic Function of Cardiac GR Knockout Mice. B. He, R.H. Oakley, P.H. Myers, J.A. Cidlowski. NIEHS/NIH. E276 687.18 Evidence of an Exaggerated Muscle Metaboreflex Response in Heart Failure with Preserved Ejection Fraction. H.L. Clifton, S.M. Ratchford, J.R. Vranish, J.D. Trinity, J.J. Ryan, R.S. Richardson, P.J. Fadel, S. Sarma, M. Haykowsky, W. Wray. Salt Lake City Veterans Affairs Medical Center, University of Utah, University of Texas at Arlington, University of Texas Southwestern Medical Center and Texas Health Presbyterian Hospital. E277 687.19 Diaphragm Muscle Function and Antioxidant Levels in Chronic Heart Failure. B.T. Hackfort, R. Lewis, L. Gao, I.H. Zucker, H.D. Schultz. University of Nebraska Medical Center. E278 687.20 Increased Circadian Variations in Chemoreflex Sensitivity in Chronic Heart Failure. R. Lewis, B.T. Hackfort, H. Schultz. University of Nebraska Medical Center. E279 687.21 Identification of HuR-Dependent Gene Expression in Cardiac Hypertrophy. S. Slone, S.R. Anthony, M.L. Nieman, J.N. Lorenz, J. Rubinstein, J.B. Benoit, M. Tranter. University of Cincinnati. E280 687.22 The Superposition of Work on a Pathologic Microenvironmental Stiffness May Regulate Actin Assembly via Phosphorylation and Sarcomeric Redistribution of PKCε. M. Mkrtschjan, A. Wondmegegn, A. Arena, J. Li, B. Russell. University of Illinois at Chicago.
688. PHYSIOLOGY OF CARDIAC MUSCLE
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Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E281 688.1 The EffectS of Quarky Ca2+ Release on Ca2+ Spark in Cardiac Myocytes. X. Chen, Y. Huo, W. Tan. College of Engineering, Peking University, People’s Republic of China, Shenzhen Graduate School, Peking University, People’s Republic of China. E282 688.2 Rewarming Shock Decreases Mitochondrial Respiratory Function in Cardiomyocytes. A. Cody, A. Eshaq, N. Schaible, Y.S. Han, T. Tveita, G. Sieck. Mayo Clinic and Artic University of Norway, Norway. E283 688.3 The Uremic Metabolite, Trimethylamine-NOxide (TMAO), Directly Alters Cardiac Contractile Function. C. Oakley, M. Hendrix, M. Grillo, D. McCarthy, J.R. Stubbs, M.J. Wacker. School of Medicine, University of Missouri-Kansas City, Kidney Institute and University of Kansas Medical Center. E284 688.4 Does β-Adrenergic/PKA Signaling Modulate Ca2+-Sensitivity and Force Kinetics in Myofibrils from Mice Carrying the FHC Related Mutation CTnI-ΔK184? G. Pfitzer, F. Elhamine, A.M. Wies, S. Zittrich, S. Papadopoulos, M.M. Schroeter, R. Stehle, D. Möhner. University of Cologne, Germany.
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PHYSIOLOGY SUNDAY E285 688.5 Differential Effects of Isoproterenol and Omecamtiv Mecarbil on the Contractile Properties of Unloaded Myocytes. J.D. Isaac, T.D. Buckley, K.S. Campbell. University of Kentucky. E286 688.6 Single Cardiac Myocytes from the Left and Right Ventricles Respond Similarly to Isoproterenol and Omecamtiv Mecarbil. T.D. Buckley, J. Isaac, K.S. Campbell. University of Kentucky. E287 688.7 Cardiac Hypertrophy and Myocyte Remodeling Are Exacerbated with Multiple Pregnancies. M. Wagner, A. Nelson, C. Flake, D. Eaton, B.A. Bailey. Ursinus College and Lewis Katz School of Medicine at Temple University. E288 688.8 Endurance Exercise Is Associated with Decreased Calpain to Calpastatin Ratios in Aged Rat Hearts. J.J. Sepe, T.A. Hacker, G.M. Diffee. University of Wisconsin-Madison. E289 688.9 Indices of Autophagy Are Unaltered by Quercetin Consumption in Hearts of Mdx/Utrn+/- Mice. J.C. Quindry, T.S. Quindry, C.G. Ballmann, J.T. Selsby. University of Montana, Samford University and Iowa State University. E290 688.10 Cardiovascular Protective Effects of AT2R Activation by Peptide Drug NP-6 A4. P. Beauparlant, A. Mahmood, R. Toedebusch, V. DeMarco, S. Ardhanari, S. Kumar, L. Pulakat. University of Missouri and Harry S. Truman VA Memorial Hospital. E291 688.11 Cardiac Myosin Binding Protein C Mutants Interact with Hsp70-Family Chaperones and Disrupt Protein Quality Control. A.A. Glazier, A. Helms, S. Kotlo, N. Hafeez, J. Yob, V. Tang, D. Mellacheruvu, A. Nesvizhskii, S. Day. University of Michigan and Johns Hopkins University.
689. ENDOTHELIAL CELL BIOLOGY I Poster (Sponsored by: APS Cardiovascular Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E292 689.1 Functional Screening of Mammalian Mechanosensitive Genes Using Drosophila RNAi Library— Smarcd3/Bap60 Is a Mechanosensitive Pro-Inflammatory Gene. S. Kumar, H. Jo. Emory University. E293 689.2 Ammonia Promotes Endothelial Cell Survival via the Heme Oxygenase-1-Mediated Release of Carbon Monoxide. W. Durante, X. Liu, K.J. Peyton. University of Missouri. E294 689.3 P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. M. Gabani, Q. Li, Y. Kim, A. Vikram, S. Kumar, M. Kassan, S. Kim, J. Jacobs, K. Irani. University of Iowa. E295 689.4 Cytosolic Active Caspase 3 Promotes Endothelial Barrier Integrity After Thrombin Stimulation. M. Damarla, L. Servinsky, K. Carino, K. Suresh, L. Johnston, L. Shimoda, P. Hassoun. JHU. E296 689.5 Effect of Uremia on Downregulation of TLR4 and Upregulation of Cytokines in Endothelial Cell. J.F. Rebello, R.B. Brito, W.R. Oliveira, G.F. Ribeiro, C.C. Grabulosa, A.S. Dias, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil.
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E297 689.6 Controlling Hydrogen Sulfide Concentrations via PDMS Microfluidics for Endothelial Cell Culture. T. Christoforidis, T. Driver, J. Rehman, D. Eddington. University of Illinois at Chicago. E298 689.7 Microparticle Uptake by Pulmonary Microvascular Endothelial Cells. A.K. Scruggs, T.C. Rich, N.N. Bauer. University of South Alabama. E299 689.8 Endothelium-Independent Vasorelaxation Induced by Nitric Oxide Generation from the Novel Organic Nitrate NDOP Is Partially Mediated by Inward-Rectifier Potassium Channels. R.B. de Paula, M.F. Montenegro, M.S. França-Silva, M.C. Brandão, T.F. Diniz, V.S. Lemos, P.F. Athayde-Filho, M. Magnani, J.O. Lundberg, M. Carlström, V.A. Braga. Federal University of Paraíba, Brazil, Karolinska Institutet, Sweden and Federal University of Minas Gerais, Brazil. E300 689.9 Phosphorylation and Redistribution of Vangl2, a Planar Cell Polarity Protein, in Endothelial Cells in Response to Laminar Shear Stress. L. Curtis-Whitchurch, H. Rekapally, J. Hoying. University of Louisville. E301 689.10 Connexin 40 Plays a Crucial Role in the Myocardial Ischemia Reperfusion Injury of Type 2 Diabetic Mice. R. Si, R. Guo, A.H. Truong, A. Makino. University of Arizona. E302 689.11 Acid Sensing Ion Channel 1 Contributes to Ca2+ Influx in Endothelial Tubes from Small Mesenteric Resistance Arteries. S.M. Garcia, L.M. Herbert, J.S. Naik, T.C. Resta, N.L. Jernigan. University of New Mexico Health Sciences Center. E303 689.12 Endothelial Specific Epithelial Sodium Channel Activation Prompts Vascular Stiffness in Female Mice. G. Jia, A.R. Aroor, B.J. Barron, C. Manrique, G. Lastra, A. WhaleyConnell, G.A. Meininger, F. Jaisser, J.R. Sowers. University of Missouri School of Medicine, UPMC University Paris 06 and Université Paris Descartes, France. E304 689.13 Sphingosine Kinase 1 and S1P Transporter Spns2 Plays Important Role in HGF Mediated Lamellipodia Formation in Lung Endothelium. P. Fu, D.L. Ebenezer, E.V. Berdyshev, M. Shaaya, A. Harijith, V. Natarajan. University of Illinois at Chicago and National Jewish Health. E305 689.14 Shear Stress Induces Apoptosis via Cytochrome C Release from Dynamic Mitochondria in Endothelial Cells. Y. Hu, S.S. Hur, L. Lei, Y. Wang, S. Chien. Institute of Engineering in Medicine, University of California at San Diego. E306 689.15 APJ Inhibition Reduces Flow-Induced Endothelial Cell Migration with Atorvastatin but Not Pravastatin Treatment. I. Materzok, F. Lorenz, M. Bahls, A. Strohbach, M. Dörr, S.B. Felix, R. Busch. University Medicine Greifswald, Germany. E307 689.16 Endothelial Cell Mechanical Responses Are Dependent on Both Fluid Shear Stress and Tensile Strain. E. Steadman, D. Meza, D.A. Rubenstein, W. Yin. Stony Brook University. E308 689.17 Microparticle Delivery of Cyclic AMP to Pulmonary Microvascular Endothelial Cells. A.K. Scruggs, S.J. Leavesley, N.S. Annamdevula, T.C. Rich, N.N. Bauer. University of South Alabama. E309 689.18 Aerobic Fitness Does Not Improve Endothelial Function and Responses to Acute Exercise in Perimenopausal Women. C. Serviente, S. Witkowski. University of Massachusetts Amherst.
SUNDAY PHYSIOLOGY E310 689.19 5-Methoxytryptophan Promotes Endothelial Cell Regeneration After Vascular Injury. Y. Ho, C. Chen, M. Wu, H. Ho, L. Liang, S. Yet. National Health Research Institutes, Taiwan.
E311 690.1 Use of Phase Loop Plots to Assess Ca2+ Sensitivity of Force Generation in Airway Smooth Muscle. Y.S. Han, G. Sieck. Mayo Clinic. E312 690.2 The Novel and Selective KV7 Channel Activator, ML213, Reveals Key Physiological Roles for KV7.4 and KV7.5 Channel Subtypes in Guinea Pig Detrusor Smooth Muscle Function. A. Provence, D. Angoli, G. Petkov. University of South Carolina. E313 690.3 TNFα Induces Mitochondrial Fragmentation and Mitochondrial Biogenesis in Human Airway Smooth Muscle Cells. E.S. Kaul, P. Delmotte, G.C. Sieck. McGill University, Canada and Mayo Clinic. E314 690.4 Differential Effects of Cannabinoid Receptor Stimulation in Smooth Muscle. A.M. Bermudez, J.M. Visina, L.A. Walker. University of Colorado, University of Portland and University of Alabama. E315 690.5 Effect of Pregnancy on Aortic and Carotid Vascular Function. M. Zynda, K.A. Klatt, J. Vallejo-Elias, K.E. Cooper, D.M. Eckman. Midwestern University. E316 690.6 In Mice, KCNQ Channel Modulators Affect Afferent Nerve Activity and Not Urinary Bladder Smooth Muscle Contractility Directly. N.R. Tykocki, T.J. Heppner, A.D. Bonev, M.T. Nelson. University of Vermont. E317 690.7 Calcium Influx Through CaV1 and TRP Channels Induced by the Calcium Release via RyR Activates BKCa in Mouse Mesenteric Artery. D.C. Garcia, M.J. Lopes, V.S. Lemos, S.F. Cortes. Federal University of Minas Gerais, Brazil.
E320 691.3 Sex Differences in Obesity-Associated Vascular/Perivascular Remodeling and Adipokine Production in Obese Patients Undergoing Roux-en-Y Bariatric Surgery. R.K. Mui, R.N. Fernandes, J.J. Galligan, G.D. Fink, C.N. Pereira-Hicks, R.E. Watson, M.K. Lane, H. Xu. Michigan State University. E321 691.4 High Fat Diet Induces Hypertension but Not Vascular and Cardiac Remodeling in Female Dahl Sensitive Rats. R. Fernandes, P.A. Perez Bonilla, H. Garver, J.J. Galligan, G.D. Fink, H. Xu. Michigan State University. E322 691.5 Microvascular Endothelial Function in Lean Versus Obese Women with Polycystic Ovary Syndrome: Role of the Endothelin B Receptor. C.W. Usselman, H.S. Taylor, N.S. Stachenfeld. John B. Pierce Laboratory and Yale University. E323 691.6 Sex Differences in Mesenteric Arterial Function at Pre-Diabetic and Diabetic Stage of UC Davis Type 2 Diabetic Mellitus Rats. S. Shaligram, F. Akther, J.L. Graham, K.L. Stanhope, P.J. Havel, R. Rahimian. University of the Pacific, University of California at Davis. E324 691.7 Sex Difference in the Patho-Physiological Consequences of Adipocyte PRR Deficiency. E. Gatineau, D. Cohn, Y. Liu, M. Gong, F. Yiannikouris. University of Kentucky. E325 691.8 Relationship Between Body Mass Index and Endothelial Dysfunction in Women with and Without Polycystic Ovary Syndrome. T.E. Adler, C.W. Usselman, L.C. Anaeto, R.G. Schapiro, F.E. Steele, N. Toffoloni, A. Takamata, H.S. Taylor, N.S. Stachenfeld. John B. Pierce Laboratory, Nara Women’s University, Japan and Yale University. E326 691.9 Obesity Amplifies the Sympathoexcitatory Response to Insulin in Male, but Not Female, Rats: Role of Neuropeptide Y Inputs Into the Paraventricular Nucleus. Z. Shi, P.A. Cassaglia, V.L. Brooks. Oregon Health & Science University. E327 691.10 Sex Differences in Mechanisms of Resistance Vessel Endothelial Dysfunction Due to Cardiometabolic Risk Factors and the Role of Endothelial Mineralocorticoid Receptors. A.P. Davel, E. Moss, I. Anwar, Q. Lu, I.Z. Jaffe. Tufts Medical Center and University of Campinas, Brazil. E328 691.11 Bardet-Biedl Syndrome 1 (BBS1) Protein Contributes to Vascular Endothelial Function. J. Jiang, J.J. Reho, K. Rahmouni. University of Iowa.
691. SEX DIFFERENCES IN OBESITY AND CARDIOVASCULAR DISEASE
692. GENETIC FACTORS AND MECHANISMS OF PREECLAMPSIA I
690. PHYSIOLOGY OF SMOOTH MUSCLE Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm
Poster
Poster
(Sponsored by: APS Cardiovascular Section)
(Sponsored by: APS Physiological Genomics Group)
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:45 pm–3:00 pm
Presentation time: 12:45 pm–3:00 pm
E318 691.1 Suppression of Aldosterone Production Via High Salt Diet and Deficiency in Endothelial Mineralocorticoid Receptors Prevents Leptin-Mediated Endothelial Dysfunction Exclusively in Female Mice. J.L. Faulkner, T. BruderNascimento, I. Jaffe, E. Belin de Chantemele. Augusta University and Tufts University. E319 691.2 BK Channel β1-Subunit Deficiency Protects Against High Fat Diet-Induced Metabolic Disorders in the Absence of Hypertension and Exacerbated Vascular Fibrosis/ Remodeling in Female Mice. H. Xu, R. Fernandes, H. Garver, J.J. Galligan, G.D. Fink. Michigan State University.
E329 692.1 Increases in Cytochrome P450 Expression and 20-HETE Production Reduce Mean Arterial Pressure in an Animal Model of Preeclampsia. J. Cotton, W. Wu, S. Murphy. University of Mississippi Medical Center. E330 692.2 Determining the Role of Maternal Leptin and Activity in Pregnancy Outcomes. T.E. Nishimura, P.M. Polgreen, L.A. Polgreen, D.S. Brandt, K.M. Thomas, S.M. Scroggins, N.J. Evans, L.B. Alexander, M.K. Santillan, D.A. Santillan. University of Iowa Hospitals & Clinics, University of Iowa College of Pharmacy and University of Iowa Graduate College.
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PHYSIOLOGY SUNDAY E331 692.3 Reduced Placental Regulator of G-Protein Signaling-2 (RGS2) and Preeclampsia. K.J. Perschbacher, J.A. Sandgren, L. Carrillo-Saenz, P.C. Witcher, N.A. Pearson, D.A. Santillan, E.J. Devor, G.L. Pierce, M.K. Santillan, R.A. Fisher, K.N. Gibson-Corley, J.L. Grobe. University of Iowa. E332 692.4 Reduced Uterine Perfusion Pressure-Induced Preeclampsia Acquires Salt-Sensitivity Characteristics in Postpartum. T. Matsuura, K. Shinohara, T. Kishi, H. Tsutsui, Y. Hirooka. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Japan, Collaborative Research Institute of Innovative Therapeutics for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Japan, Department of Advanced Cardiovascular Regulation and Therapeutics, Center for Disruptive Cardiovascular Medicine and Kyushu University, Japan. E333 692.5 Pre-Conception Leptin Resistance Characterizes the BPH/5 Mouse Model of Preeclampsia. E.F. Sutton, H.E. Lob, C. Liu, L.M. Redman, R.L. Davisson, J.L. Sones. Louisiana State University, Cornell University, Louisiana State University School of Veterinary Medicine and Weill Cornell Medical College. E334 692.6 Altered Water Homeostasis in a Novel NonHuman Primate Model of Gestational Hypertension. C.C. Weaver, M.K. Rhoads, J.L. Grobe, J.L. Osborn. University of Kentucky, University of Iowa Carver College of Medicine and Biomedical Science Research Group. E335 692.7 Preeclampsia Alters Androgen MetaboliteInduced Vasorelaxation of Rat Uterine Artery. A.E. Hanson, J.N. Stallone. Texas A&M University. E336 692.8 Expression of MEF2 Transcription Factors in Human Placenta and Involvement in Trophoblast Invasion and Differentiation. L. Li, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center.
693. NEUROINFLAMMATION/NEUROPROTECTION/ ISCHEMIA
E341 693.5 In Vitro Analysis of Catalase-, Oxidase- and SOD-Mimetic Activity of Commercially Available and CustomSynthesized Cerium Oxide Nanoparticles and Assessment of Neuroprotective Effects in a Hippocampal Brain Slice Model of Ischemia. A.Y. Estevez, B. Stadler, J.S. Erlichman. St. Lawrence University and CerionNRx. E342 693.6 Neural Stem Cells Reduce Symptomatic Inflammation and Mortality in Aged Stroke Mice Following Delayed tPA Treatment. A.D. Eckert, M. Hamblin, J. Lee. Tulane University Health Science Center. E343 693.7 Macrophage Heterogeneity and Stem Cell Derived Tyrosine Kinase (STK) Regulate Chronic CNS Inflammation in Diet Induced Obesity (DIO). A. Dey, J.N. Allen, J.W. Fraser, R.F. Paulson, P. Hankey-Giblin. Penn State University. E344 693.8 Chronic Ketosis Modulates Metabolite Profiles and Cell-Signaling Pathways in Mouse Brain. J. LaManna, K. Sharma, D. Ye, J.M. Berthiaume, Y. Luo, K. Xu, M.A. Puchowicz. Case Western Reserve University. E345 693.9 Behavioral and Inflammatory Response in Animals Exposed to a Low-Pressure Blast Wave and Supplemented with β-Alanine. J.R. Hoffman, A. Zuckerman, O. Ram, O. Sadot, J.R. Stout, I. Ostfeld, H. Cohen. University of Central Florida, Ben-Gurion University, Israel, Ben Gurion University, Israel and Israel Defense Forces, Israel. E346 693.10 Mitochondrial Transplantation Restores Bioenergetics After Spinal Cord Injury. J. Gollihue, S. Patel, K. Eldahan, D. Cox, A. Rabchevsky. University of Kentucky. E347 693.11 NMDA Receptor-Mediated Synaptic Transmission in the Spinal Dorsal Horn and Spinal Nerve Ligation-Induced Nociceptive Behavior Are Enhanced in Serine Racemase Knockout Mice. T. Fukushima, E. Kato, R. Konno, Y. Hori. Dokkyo Medical University, Japan.
694. CELLULAR MECHANISMS OF STRESS AND INFLAMMATION Poster
Poster (Sponsored by: APS Central Nervous System Section)
(Sponsored by: APS Cell and Molecular Physiology Section)
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:45 pm–3:00 pm
Presentation time: 12:45 pm–3:00 pm
E337 693.1 Identification of a Molecular Mechanism Underlying Estrogen-Mediated Neuroprotection in Neuronal Cells Against Oxidative Stress. S. Park, J. Won, Y. Hong. College of Biomedical Science & Engineering, Inje University, Republic of Korea, Graduate School of Inje University, Republic of Korea, Inje University, Republic of Korea. E338 693.2 Dihydrotestosterone Mediates Neuroprotective Effects via Estrogen Receptor Beta Following Brain IschemiaReperfusion Injury in Male Mice. S. Shi, Q. Liu, R.J. Gonzales. University of Arizona and Barrow Neurological Institute. E339 693.3 Neuroprotective Effect of Low Dose Alcohol Consumption Against Transient Focal Cerebral Ischemia. K.D. McCarter, H. Sun, C. Li. LSU Health Sciences Center -Shreveport. E340 693.4 Reciprocal Control of Apoptotic Cell Death and Synaptic Plasticity by DAPK1 Depletion in Focal Cerebral Ischemic Brain. J. Won, S. Park, Y. Hong. Inje University, Republic of Korea.
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E348 694.1 The Protective Role of NHERF1 in CisplatinInduced Acute Kidney Injury. A.M. Bushau-Sprinkle, A.R. Sherwood, C.A. Conklin, M.T. Barati, T. Dupre, L. Siskind, K.B. Gagnon, S.J. Khundmiri, E.D. Lederer. University of Louisville, Howard University and Robley Rex Veteran Affairs Medical Center. E349 694.2 Inhibition of PDE7 Reduces Inflammatory Response Following Renal Ischemia/Reperfusion Injury. W.R. Reis, M.A. Sun, T.A. Kronk, M.A. Blount. Emory University School of Medicine. E350 694.3 The Glycolysis Regulatory Enzyme PFK-FB3 Enhances Endothelial Barrier Restoration in Acute Lung Injury. L. Wang, P. Chaturvedi, S. Krantz, J. Klomp, N.M. Pohl-Avila, A. Ray, P.T. Toth, P. Carmeliet, A. Karginov, A.B. Malik, J. Rehman. UIC and VIB Vesalius Research Center, Belgium. E351 694.4 Inactivation of the PLA2 Activity of Prdx6 Ameliorates Sepsis-Induced Acute Lung Injury. J. VazquezMedina, J. Tao, P. Patel, C. Dodia, E. Sorokina, S.I. Feinstein, S. Chatterjee, A.B. Fisher. University of Pennsylvania.
SUNDAY PHYSIOLOGY E352 694.5 Expression of a Pulmonary Fibrosis Associated Surfactant Protein C Mutant, SP-CI73T, in Alveolar Type 2 Cells Induces Lung Inflammation and Aberrant Parenchymal Remodeling. A. Venosa, Y. Tomer, S. Jamil, M. Beers. University of Pennsylvania. E353 694.6 Proteomic Analysis Identifies Matrix Metalloproteinase-9 and -12 Regulated Apoptosis Substrates in the Post-Myocardial Infarction Left Ventricle. R.P. Iyer, E.R. Flynn, Y. Ma, M.L. Lindsey. University of Mississippi Medical Center and G.V. (Sonny) Montgomery Veterans Affairs Medical Center. E354 694.7 Mitochondrial Transcription Factor A and Cardiac Stability. G.H. Kunkel, N. Theilen, N. Jeremic, G. Weber, S.C. Tyagi. University of Louisville School of Medicine. E355 694.8 Divergent Effects of DHA Treatment and AMPK Activation on Protein Synthesis Rate and Signaling in Palmitate-Treated Skeletal Muscle. B.D. Perry, J.A. Rahnert, Y. Xie, P. Zhang, D. Espinosa, S. Price. Emory University and VA Medical Centre. E356 694.9 Contribution of Membrane Repair Defects to Skeletal Muscle Inflammation. K.E. McElhanon, N. Young, J. Hampton, E.X. Beck, Z. Sahenk, R. Aggarewal, C.V. Oddis, W.N. Jarjour, N.E. Weisleder. The Ohio State University, Research Institute at Nationwide Children’s Hospital and University of Pittsburgh. E357 694.10 Interleukin-10 in Type 1 Diabetes-Induced Bone Loss in Mice. N.D. Rios-Arce, S. Mohr, B. Coughlin, D. Feenstra, B. Christian, L.R. McCabe, N. Parameswaran. Michigan State University.
695. CELLULAR RESPONSES TO INFLAMMATION Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E358 695.1 Unravelling the Identity of Active Serine Proteases in Inflammatory Bowel Diseases. N. Vergnolle, C. Deraison, B. Chrystelle, A. Edir, B. Gilmore, M. Quaranta, M. Sebert, L. Alric, D. Bonnet, N. Bunnett, A. Denadai Souza. Inserm U-1220, France, Queen’s University, Ireland, CHU Toulouse, France and Columbia University. E359 695.2 The Host Engulfment Pathway in Enteroids Is Linked to Intestinal Inflammation Following Bacterial Infection. S. Das, E. Lim, K. Suarez, P.B. Ernst, K.E. Barrett. University of California San Diego. E360 695.3 Bacteria-Neutrophil Crosstalk: Genomic Approaches Identify G Protein-Coupled Receptors as New, Potential Targets for the Treatment of Infections. R. Corriden, K. Sriram, P.A. Insel. University of California at San Diego. E361 695.4 25(OH)D3 Treatment Improves Inflammatory Pathway on Monocytes Lineage (U937) in Uremic Environment. R.B. de Oliveira Brito, J.F. Rebello, W.R. ‘dos Santos Oliveira, C.C. Grabulosa, Y.S. Matos, C.S. Malta, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil. E362 695.5 Interferon Type II Increases Lipolysis and Fatty Acid Oxidation in Pancreatic β Cells. N. Truong, J. Bazil, L. Olson. Michigan State University.
E363 695.6 Acute High Fat Diet Exposure Results in Discrete Shifts in the Adipose Tissue Inflammation Profile in Mice. B. Hetrick, A. Huffard, C. McCurdy. University of Oregon.
696. OXIDATIVE STRESS, MITOCHONDRIAL METABOLISM AND REDOX CHANGES IN HEALTH AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E364 696.1 The Effects of Conjugated Linoleic Acid and Berberine Supplementation on Markers of Oxidative Stress in Broiler Chickens. V. Dartigue, H. Klandorf, E. Falkenstein, K. Barnes, K. Van Dyke. West Virginia University, and West Virginia University School of Medicine. E365 696.2 Reversal of Ciprofloxacin-Induced Testosterone Reduction by Probiotic Microbes in Mouse Testes. C. Xie, F. Gao. Hebei Normal University, People’s Republic of China. E366 696.3 Phenotypic Abnormalities in Microvascular Endothelial Cells Isolated from the Sugen/Hypoxia Rat. K. Suresh, L. Servinsky, J. Huetsch, L. Shimoda. Johns Hopkins University. E367 696.4 The Mitohormetic Response and an Evaluation of a Method for Inducing Oxidative Damage. Y. Zhang, F. Humes, A. Brasher, A. Kavazis, W. Hood. Auburn University. E368 696.5 The Mitochondrial Adenine Nucleotide Pool Contributes to the Matrix Ca2+ Buffering System. A.J. Davani, C.D. Navarro, J.S. Heisner, V.R. Pannala, R.K. Dash, D.F. Stowe, A.K. Camara. Medical College of Wisconsin, Research Service and Zablocki VA Medical Center. E369 696.6 Estradiol Receptor Agonists α and β Protect Against Brain Mitochondrial Dysfunction in a Model of Sleep Apnea. S. Laouafa, A. Bairam, J. Soliz, D. Roussel, V. Joseph. IUCPQ, Université Laval, Canada, CNRS, UMR 5023—LEHNA and Université Claude Bernard Lyon 1., France. E370 696.7 Mitochondrial-Targeted Peptide SBT-20 Improves Mitochondrial Bioenergetics in Duchenne Muscular Dystrophy in a Mitochondrial Creatine Kinase Dependent Manner. M.C. Hughes, S.V. Ramos, N. Polidovitch, P. Backx, C.G. Perry. York University, Canada. E371 696.8 Hydrogen Sulfide Attenuates HomocysteineInduced Mitochondrial Toxicity in MC3T3-E1 Pre-Osteoblastic Cells. Y. Zhai, J. Behera, S. Tyagi, N. Tyagi. School of Medicine and University of Louisville. E372 696.9 Mitochondrial Fragmentation Is a Novel Feature of Adherent-Invasive E. coli Evoked Pathophysiology in Enteric Epithelia. N. Mancini, A. Wang, J. Shearer, D. McKay. University of Calgary, Canada. E373 696.10 Muscle gp130 Receptor Regulation of Oxidative Metabolism During Cancer Cachexia. D. Fix, J. Hardee, S. Gao, B. VanderVeen, J.A. Carson. University of South Carolina.
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PHYSIOLOGY SUNDAY E374 696.11 Nicorandil Reduces Lipoperoxidation in Stimulated and Non-Stimulated Atrophied Muscle. A. Sanchez-Perez, P. Padilla-Maldonado, E. Sanchez-Duarte, C. Coretes-Rojo, A. Saavedra-Molina, M. Gomez-Barroso, R. Montoya-Perez. Universidad Michocana de San Nicolas de Hildalgo, Mexico, Universidad de Colima, Mexico. E375 696.12 Up-Regulation of Nox4 Expression in DUSP4/- Hearts Is a Critical Factor in Modulating Cardiovascular Function Under Oxidative Stress. J.P. Lamb, A. BarajasEspinoza, A. Basye, M. Angelos, C. Chen. The Ohio State University College of Medicine.
697. INFLAMMATION AND AUTONOMIC REGULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E376 697.1 Chronic Inflammation Deactivated the MAPK Pathway and Decreased the TRPV1 Protein Expression in the 50B11 Dorsal Root Ganglion Cell Line. H. Wang, G.J. Rozanski, I.H. Zucker. University of Nebraska Medical Center. E377 697.2 Local Innervation Modulates Lymph Node Cellularity. C. Chen, L. Ince, A. de Juan, S. Hergenhan, W. He, D. Druzd, K. Kraus, C. Scheiermann. LMU Munich, Germany. E378 697.3 Distinguishing the Central Pathways of the Inflammatory Reflex from Those of Fever. D. Martelli, D.G. Farmer, S.T. Yao, M.J. McKinley, R.M. McAllen. Florey Institute of Neuroscience and Mental Health, Australia and University of Bologna, Italy. E379 697.4 Renal Inflammatory Response Mediated by Chronic Pain and Related Stress. B.B. Duong, M.L. Carder, G.S. Crosby, V. Duric, V. Babich, F. Di Sole. Des Moines University and Mercy College of Health Sciences. E380 697.5 Renal Denervation Prevents Nicotine-Induced Hypertension and Reduces Renal IL-17a. S.C. Harwani, J. Ratcliff, M.Z. Cicha, M.W. Chapleau, F.M. Abboud. University of Iowa. E381 697.6 Acute Electrical Vagal Nerve Stimulation Exerts Powerful Anti-Inflammatory Effects Through Its Nicotinic Action in Rats with Pulmonary Arterial Hypertension. K. Yoshida, K. Saku, M. Tanaka, K. Abe, T. Kishi, H. Tsutsui, K. Sunagawa. Kyushu University Graduate School of Medical Sciences, Japan and Kyushu University, Japan. E382 697.7 Decrease in Inflammation (CRP) and Heart Rate Through Mirthful Laughter. G. Bains, L. Berk, E. Lohman, N. Daher, B. Miranda. Loma Linda University. E383 697.8 Disruption of Mitochondrial Redox and Metabolic States in Norepinephrine-Exposed T-Lymphocytes. A.J. Case, C.W. Collins, C.T. Roessner, J. Tian, M.C. Zimmerman. University of Nebraska Medical Center. E384 697.9 The Therapeutic Potential of Modified DeepOcean Water on 2,4-Dinitrochlorobenzene Induced Atopic Dermatitis in Balb/c Mice. C. Ho, C. Chien. National Taiwan Normal University, Taiwan.
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698. RENAL OXIDATIVE STRESS AND HYPOXIA Poster (Sponsored by: APS Renal Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E385 698.1 Chronic Electronic Cigarette Vapor Inhalation Induces Renal Injury and Functional Decline in Female Mice. C. Drummond, L.E. Crotty Alexander, J. Tian. University of Toledo, University of California San Diego and Veterans Affairs San Diego Health System. E386 698.2 Hypoxia/Re-Oxygenation Increases the Response of Afferent Arterioles to Angiotensin II—Investigation in Mouse Kidney Slices. T. Pahlitzsch, D. Braun, M. Ludwig, P.B. Persson, A. Patzak. Charité-Universitätsmedizin Berlin, Germany. E387 698.3 The Impaired Vasodilatation in Rat Renal Interlobar Arteries After Hypoxia/Re-Oxygenation Is Endothelium Independent. D. Braun, M. Ludwig, P.B. Persson, S. Dietze, A. Patzak. Charite-Universitätsmedizin Berlin, Germany. E388 698.4 Acute Kidney Injury Induces Oxidative Stress and Distant Organ Dysfunction Due to Glutathione Depletion. Y. Shang, Y.L. Siow, C.K. Isaak, K. O. St. Boniface Hospital Research Centre, Canada, University of Manitoba, Canada and Agriculture and Agri Food Canada, Canada. E389 698.5 Intra-Operative Urinary Hypoxia During Cardiac Surgery on Cardiopulmonary Bypass Predicts Later Development of Acute Kidney Injury. R.G. Evans, M.Z. Zhu, J.A. Smith, G.K. Harrop, A.G. Thrift, A.D. Cochrane. Monash University, Australia and Monash Health, Australia. E390 698.6 The Effects of Telmisartan on Ischemia/ Reperfusion Injury of Rat Kidney. P. Lee. Tzu Chi University of Science and Technology, Taiwan. E391 698.7 Tempol Prevents the Enhancement of Angiotensin II Contractions of Afferent Arterioles from Mouse with Reduced Renal Mass. L. Li, E. Lai, Z. Luo, K.K. Griendling, W.K. Taylor, A. Wellsten, W. Welch, C.S. Wilcox. Georgetown University, Zhejiang University, People’s Republic of China, and Emory University. E392 698.8 Intermittent Hypoxia Increases Blood Pressure in Rats with Chronic Kidney Disease but Does Not Increase Fibrosis, Inflammation or Loss of Endothelial Dilators. J.L. Riggs, C.E. Pace, W. Giermakowska, H.H. Ward, L.V. Gonzalez Bosc, N.L. Kanagy. University of New Mexico Health Sciences Center.
SUNDAY PHYSIOLOGY
699. CELLULAR RESPONSE TO HYPOXIA Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E393 699.1 Withdrawn. E394 699.2 Withdrawn. E395 699.3 Surviving Low Oxygen: Exploring the Role of AMP-Activated Kinase in Anoxia-Tolerance. A.V. Carter. University of Maryland: Baltimore County.
700. CELLULAR AND INTEGRATED RESPONSES TO HYPOXIA Poster
E403 700.8 Hypoxia Activates BK and Kv Channels in Rat Carotid Body Glomus Cells. D. Kim, J. Wang. Rosalind Franklin University. E404 700.9 Effects of Hypoxia on Hydrogen Sulfide Production and Degradation Gene Expression Pathways. L.G. Forgan, B.A. McNeill, E. DeLeon, Y. Gao, K. Olson. Deakin University, Australia and Indiana University. E405 700.10 Identification of Vesicular Monoamine Transporter 2 (vmat2)-Containing O2 Chemoreceptors in the Gills of Zebrafish. W. Pan, A.L. Scott, C.A. Nurse, M.G. Jonz. University of Ottawa, Canada and McMaster University, Canada. E406 700.11 HOIL-1L and PKCζ Are Required for Na,KATPase Stabilization at the Plasma Membrane During Hypoxia. N.D. Magnani, M.A. Queisser, L.A. Dada, L.C. Welch, P. Brazee, A. Misharin, S.G. Budinger, J.I. Sznajder. Northwestern University.
701. RENAL HEMODYNAMICS, GLOMERULAR FILTRATION AND RENAL VASCULATURE
(Sponsored by: APS Hypoxia Group)
Poster
Sun. 9:00 am—McCormick Place Convention Center, Hall F
(Sponsored by: APS Renal Section)
Presentation time: 12:45 pm–3:00 pm E396 700.1 Cardiovascular Adaptations to Moderate Anemia Maintain Cerebral Perfusion but Are Inadequate to Prevent Renal and Splanchnic Tissue Hypoxia. N. Mistry, M. Solish, L. Cahill, Y. Zhou, A.G. Hare, A. Doctor, A.H. Lazarus, J.G. Sled, C. Mazer, G.M. Hare. St. Michael’s Hospital, Canada, University of Toronto, Canada, The Hospital for Sick Children, Canada and Washington University in St. Louis. E397 700.2 EffectS of DIfferent Oxygen Concentrations on Human Differentiated Preadipocytes Lipogenic and Lipolytic Functions. B. Mahat, J. Mauger, P. Imbeault. University of Ottawa, Canada. E398 700.3 Berlin Questionnaire Is a Useful Tool to Identify Risk of Obstructive Sleep Apnea in Metabolic Syndrome Patients. F.X. Cepeda, L. Virmondes, S. Rodrigues, A.C. Dutra-Marques, J.C. Carvalho, E. Toschi-Dias, M.N. Alves, M. Rondon, W.R. Lopes-Vicente, M.F. Hussid, G. LorenziFilho, I.C. Trombetta. Heart Institute (InCor), University of São Paulo Medical School, Brazil, Universidade Nove de Julho (UNINOVE), Brazil, School of Physical Education and Sports and University of São Paulo, Brazil. E399 700.4 Effect of Carotid Sinus Nerve Transection on Ventilation in Juvenile (P25) Male Sprague-Dawley Rats. P.M. Getsy, G.A. Coffee, S.J. Lewis. Case Western Reserve University. E400 700.5 Comparison of the Ventilatory Responses Elicited by Hypoxic Gas Challenge in Freely-Moving C57BL6 and A/J Male Mice. G.A. Coffee, P.M. Getsy, S.J. Lewis. Case Western Reserve University. E401 700.6 Cardiorespiratory Responses to Severe Arterial Hypoxemia with Increasing Remifentanil Plasma Concentrations in the Rabbit. A.W. Quail, D.B. Cottee, J.M. Johnstone, K. O’Hara, S.W. White. University of Newcastle, Australia. Channels (KV) E402 700.7 Voltage-Dependent K+ Suppress Hypoxia-Induced Elevation of [Ca2+]i in Rat Carotid Body Glomus Cells. J. Wang, J.O. Hogan, D. Kim. Rosalind Franklin University of Medicine and Science.
Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E407 701.1 Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Coexisting Metabolic Syndrome and Renovascular Disease in Swine. A. Eirin, X. Zhu, C.M. Ferguson, A.J. van Wijnen, A. Lerman, L.O. Lerman. Mayo Clinic. E408 701.2 Susceptibility to Pressure-Induced Renal Injury in DOCA-Salt vs. Angiotensin II Hypertensive Rats. A.J. Polichnowski, K. Griffin, P. Sethupathi, V. Patel, M. Patel, M. Picken, G. Williamson, A. Bidani. East Tennessee State University, Hines VA Hospital and Loyola University Chicago and Illinois Institute of Technology. E409 701.3 Imaging Renin Granule Exocytosis in Juxtaglomerular Cells by Total Internal Reflection (TIRF) Microscopy. M. Mendez. Henry Ford Hospital. E410 701.4 Direct Evidence That in Rat the Renal Interstitium Contracts in Vivo. M. Rodríguez-Martínez, J. López-Rodríguez, O. Flores-Sandoval, M.Z. CalvoTurrubiartes, L. LLamazares-Azuara. Faculty of Medicine UASLP, Mexico. E411 701.5 Adenosine A1 Receptor-Operated Calcium Entry in Renal Afferent Arteriolar Smooth Muscle Cells Is Dependent on Postnatal Maturation of Canonical Transient Receptor Potential Isoform 3 Channels. D. Peixoto-Neves, H. Soni, R.K. Buddington, A. Adebiyi. University of Tennessee Health Science Center and University of Memphis. E412 701.6 Role of Gap Junctions in Renal Vascular Conducted Response. S. Moller. University of Copenhagen, Denmark. E413 701.7 TRPV4 Channels Contribute to Renal Myogenic Response in Neonatal Pigs. H. Soni, D. Peixoto-Neves, A. Adebiyi. University of Tennessee Health Science Center. E414 701.8 A New View of Macula Densa Cell Biology. U. Shroff, L. Perin, J. Peti-Peterdi. University of Southern California.
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PHYSIOLOGY SUNDAY E415 701.9 Macula Densa Cell Gene Profiling. A. RiquierBrison, D. Desposito, J. Moon, J. Peti-Peterdi. University of Southern California. E416 701.10 Glucagon-Like Peptide-1 Affects Mean Arterial Pressure, Renal Blood Flow and Urinary Flow Rate in Spontaneously Hypertensive Rats Despite No Renal Expression of GLP-1 Receptors. C.M. Sorensen, J. Ronn, J.J. Holst, E.P. Jensen. University of Copenhagen, Denmark. E417 701.11 JGA-Derived CCN1 Is a Systemically Acting Angiogenic Hormone. D. Desposito, J. Moon, A. RiquierBrison, J. Peti-Peterdi. University of Southern California. E418 701.12 A New View of Macula Densa Cell Microanatomy. G. Gyarmati, J. Moon, A. Riquier Brison, J. Peti-Peterdi. University of Southern California.
702. PH HOMEOSTASIS AND ACIDBASE TRANSPORT Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E419 702.1 Renal Response to Acidosis: RNA-Seq and Role of NaDC1. S. Yadav, W. Huang, J. Coleman-Barnett, L. Hamm, K.S. Hering-Smith. Tulane University School of Medicine. E420 702.2 Renal Role of Gprc5c in Regulating Systemic pH Homeostasis. P. Rajkumar, B. Cha, M. Donowitz, Y. Hirabayashi, L.J. Arend, J.L. Pluznick. Johns Hopkins School of Medicine and RIKEN Brain Science Institute, Japan. E421 702.3 Characterization of pHi Regulation by NBCe1/ SLC4A4 Variants with Known Clinical Phenotypes in Human Immortalized Trabecular Meshwork Cells with a Red-Shifted Genetically-Encoded pH-Indicator “pHire”. A.J. Rossano, P.N. Caldas Font, H.L. Holmes, M.F. Romero. Mayo Clinic College of Medicine and University of Puerto Rico, Puerto Rico. E422 702.4 The Choroid Plexus Sodium-Bicarbonate Cotransporter NBCe2 Regulates Cerebrospinal Fluid pH. D. Barbuskaite, J. Praetorius, H.L. Christensen, A. Rojek, H.M. Nielsen, E. Fuchtbauer, T. Wang, H.H. Damkier. University of Copenhagen, Denmark and Aarhus University, Denmark. E423 702.5 Nominal Carbonic Anhydrase Activity Mitigates Airway-Surface Liquid pH Changes During the Respiratory Cycle. I.M. Thornell, X. Li, X. Tang, J.L. Zabner, M.J. Welsh. University of Iowa.
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703. EPITHELIAL TRANSPORT GROUP I Poster (Sponsored by: APS Epithelial Transport Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E424 703.1 Importance of Adenylyl Cyclase 6 in Developing Lithium-Induced Nephrogenic Diabetes Insipidus. S.B. Poulsen, T.B. Kristensen, H.L. Brooks, T. Rieg, R.A. Fenton. Aarhus University, Denmark, VA San Diego Healthcare System, University of Arizona and University of California San Diego. E425 703.2 Curation of Renal Inner Medullary Collecting Duct Proteome Database with Sequence-Based Searching Using K-Blast. B. Medvar, T. Pisitkun, A. Sarkar, M. Knepper. NHLBI, NIH and The Catholic University of America. E426 703.3 Intestinal Adenylyl Cyclase 6 Mediates Cholera Toxin-Induced Diarrhea. T. Rieg, I. Kaji, Y. Akiba, J. Kaunitz, S.B. Poulsen, J.A. Dominguez Rieg, R.A. Fenton. UCSD & VASDHS, UCLA & Greater LAVAHS, Aarhus University, Denmark and Bastyr University California. E427 703.4 ER and Mitochondria Regulate Intracellular Ca2+ and ENaC in Mouse Renal CCD Principal Cells. L.W. Li, L. Galarza-Paez, L. Zhou, V.A. Linck, B. Duke, O. Al-Khalili, T.L. Thai, D.C. Eaton. Emory University. E428 703.5 The Divergent Redox Sensitivities of d- and aEpithelial Sodium Channel (ENaC) Subunits. M.N. Helms, W. Wu. University of Utah and University of California San Diego. E429 703.6 H,K-ATPase Type 2 Participates in the Adaptive Proliferation of Quiescent Renal A-Type Intercalated Cells in Response to K+ Depletion. G. Crambert, L. Cheval, A. Doucet, A. Edwards, C. Walter. Centre de Recherche des Cordeliers - INSERM U1138 - CNRS ERL8228, France and Boston University. E430 703.7 Upregulation of miR-21-5p and VMP-1 Precede Apical Bleb Formation in Renal Ischemia. V. Singh, M. Paterson, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. E431 703.8 AVP Dynamically Increases Paracellular Na+ Permeability and Transcellular NaCl Transport in the Medullary Thick Ascending Limb of Henle’s Loop. J. Leipziger, N. Himmerkus, A. Plain, R.D. Marques, S. Sonntag, A. Paliege, M. Bleich. Aarhus University, Denmark, Chrisitan Albrechts University Kiel, Germany, Charité and Universitätsmedizin Berlin, Germany. E432 703.9 A Role for p38 in Bile Acid (BA)-Mediated Tight Junction (TJ) Dysfunction in Human Colon T84 Cells. T. Nair, H. Sirajuddin, M. Ao, S. Alendry, L. Haery, J. Domingue, M. Rao, J. Sarathy. Benedictine University and University of Illinois at Chicago. E433 703.10 Hydrophobic Residues in the Zonula Occludens-1 (ZO-1) ZU5 Domain Contribute to Essential Junctional Activity. J.M. King, N.C. Thomason, A.R. White, K.M. Kannen, L. Shen, J.R. Turner. Trinity Unversity, University of Chicago, Brigham and Women’s Hospital and Harvard Medical School. E434 703.11 Ischemia Leads to Increases in Tight Junction Mobility Following FRAP in Vivo. A. Kolb, K. Amsler, R. Bacallao. Indiana University Purdue University Indianapolis, Roudebush VAMC, NYIT College of Osteopathic Medicine and Indiana University School of Medicine.
SUNDAY PHYSIOLOGY E435 703.12 Identification of β-Catenin Interacting Proteins in the Nuclei of Native Rat Renal Inner Medullary Collecting Duct Cells. J. Hwang, H. Jung, C. Chou, M. Knepper. NHLBI and NIH. E436 703.13 Autophagy Prevents Downregulation of AQP1 Protein Induced by Ischemia/Reperfusion in Cultured IMCD3 Cells. Q. Liu, S. Hu, W. Dong, X. Liang, C. Li, W. Wang. Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, People’s Republic of China, Guangdong General Hospital, People’s Republic of China. E437 703.14 Altered Expression of Aquaporin Water Channels in a Rat Model of Chronic Diarrhea Due to Bile Acid Malabsorption. J. Yde, J. Borg, R.A. Fenton, H.B. Moeller. Aarhus University, Denmark. E438 703.15 Molecular Basis of AVP-Regulated Calcium Signaling in the Collecting Duct. M. Mamenko, I. Dhande, V. Tomilin, O. Zaika, P.A. Doris. The University of Texas Health Science Center at Houston, Medical College of Georgia and Augusta University. E439 703.16 A Study on Mechanism and Potential Application of Novel Chalconoid Derivatives as Anti-Secretory Therapy for Diarrheal Diseases. C. Yibcharoenporn, W. Chavasiri, V. Chatsudthipong, C. Muanprasat. Mahidol University, Thailand and Chulalongkorn University, Thailand. E440 703.17 Fungus-Derived Zearalenone as an Inhibitor of cAMP-Dependent Chloride Secretion in Human Colonic Epithelial T84 Cells. P. Muangnil, K. Tadpetch, V. Rukachaisirikul, V. Chatsudthipong, C. Muanprasat. Mahidol University, Thailand and Prince of Songkla University, Thailand. E441 703.18 A Screen for Potassium Sensitivity in Yeast Reveals Endosomal Sorting Factors That Regulate the Renal Outer Medullary Potassium (ROMK) Channel. T.D. Mackie, P.A. Welling, A.R. Subramanya, J.L. Brodsky. University of Pittsburgh and University of Maryland Baltimore. E442 703.19 Renal Epithelial Function Can Be Altered by Hypoxia Inducible Mechanisms. S.S. Nag, A.H. Resnick. Cleveland State University. E443 703.20 Effect of Diuretics and Gender on Kcnj16Mediated Effects in Salt Sensitive Hypertension. O. Palygin, V. Levchenko, O. Prudnikov, C. Nguyen, A. Staruschenko. Medical College of Wisconsin.
704. PROKARYOTIC TRANSPORT, METABOLISM, AND CELL SIGNALING IN NUTRITION, HEALTH, AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E444 704.1 Select Moringa oleifera Subfractions Exhibit Potent Antibacterial Properties Against Escherichia coli. T. Orders, S. Nair, B. Smith, J. Slate, N. Moreano, E. Oyugi, S. Reinker, Y. Salih, R. Maisura, A. Payne, J. Emrani, J. Idassi, M. Frank, C.N. Mowa. Appalachian State University and American Physiological Society.
E445 704.2 Death by a Thousand Cuts: Moringa oleifera Lysis Escherichia coli by Altering Multiple Biological Processes. B. Smith, T. Orders, J. Emrani, J. Idassi, M. Frank, C.N. Mowa. Appalachian State University, North Carolina A & T and American Physiological Society.
705. BLOOD BRAIN BARRIER, BRAIN BLOOD FLOW AND METABOLISM Poster (Sponsored by: APS Central Nervous System Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E446 705.1 Early Post-Ischemic Blood-Brain Barrier (BBB) Disruption in Long-Standing Obesity. C. Li, G. Xu, K.D. McCarter, H. Sun. Louisiana State University Health Sciences Center-Shreveport. E447 705.2 Oxygen Glucose Deprivation Modulates Endothelial Ca2+ Signal Mediated by TRPV4-KCa Channels. M.T. Lin, C. Choi, X. Zha, F. Yap. University of South Alabama. E448 705.3 Transcranial Direct Current Stimulation Transiently Increases the Blood-Brain Barrier Solute Permeability in Rat Brain. B. Fu, D. Shin, N. Khadka, J. Fan, M. Bikson. The City College of the City University of New York. E449 705.4 Changes in the Oxyhemoglobin Dissociation Curve and Cerebral Oxygenation During Acute Systemic Inflammation in Healthy Volunteers. R. Dahl, R. Plovsing, R. Berg. University Hospital Rigshospitalet, Denmark and Frederiksberg and Bispebjerg Hospitals, Denmark.
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706. AUTONOMIC CONTROL AND AUTOREGULATION OF THE CEREBRAL CIRCULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E450 706.1 Cerebrovascular Responses to Trigeminal Nerve Stimulation in Humans. A. Ahmed, L. Edwards, I.D. Braz, J.P. Fisher. University of Birmingham, United Kingdom. E451 706.2 Impaired Dynamic Cerebral Autoregulation to Postural Stress Following Concussive Injuries in Adolescents. M.E. Moir, K.C. Abbott, C.S. Balestrini, L.K. Fischer, D.D. Fraser, J.K. Shoemaker. Western University, Canada and Children’s Health Research Institute, Canada. E452 706.3 Blast Exposure with mTBI Is Associated with Impaired Cerebral Blood Flow in US Veterans. J.M. Serrador, Y. Haber, K. Brewer, L. De La Cruz, M. Falvo. Dept of Veteran Affairs and Rutgers.
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707. ACUTE EXERCISE RESPONSES Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E453 707.1 Fatigue and Motor Unit Activation Are Determined by Neither Load Nor Time Under Tension During Resistance Exercise. R. Morton, M. Sonne, A. Farias Zuniga, A. Jones, P. Keir, C. McGlory, S. Phillips. McMaster University, Canada. E454 707.2 Effects of Resting Muscle Carnosine Content on the Intramuscular Antioxidant Response to a Bout of Resistance Exercise. A.N. Varanoske, J.R. Hoffman, D.D. Church, A.R. Jajtner, J.R. Townsend, K.S. Beyer, L.P. Oliveira, D.H. Fukuda, J.R. Stout. University of Central Florida. E455 707.3 IL-6 Contributes to Exercise Induced Recovery of Hepatic Insulin Action in Obese Mice. W.T. Peppler, R.E. MacPherson, M.R. Panasevich, G.M. Meers, R.S. Rector, D.C. Wright. University of Guelph, Canada, Brock University, Canada, University of Missouri and Harry S Truman Memorial VA Hospital. E456 707.4 Maturity Related Differences in Systemic and Localized Fatigue Thresholds Amongst Adolescent Male Athletes. K.S. Beyer, J.R. Stout, M.J. Redd, K.M. Baker, D.H. Fukuda, J.R. Hoffman. University of Central Florida. E457 707.5 Physical Capacity and Energy Expenditure of Cavers. v. Pinna, S. Magnani, G. Sainas, G. Gihiani, S. Vanni, F. Tocco, G. Antoni, A.C. Rinaldi, A. Crisafulli. University of Cagliari, Italy. E458 707.6 Effects of the Different Acute Exercise on Serum Cortisol of Undergraduate. J. He, P.Y. Sun, L.L. Qiu. East China Normal University, People’s Republic of China. E459 707.7 Single- vs. Double-Leg Cycling: Lower Cardiorespiratory Demands and Perceived Effort for a Greater Relative Power Output. M.J. MacInnis, N. Morris, M.W. Sonne, A. Farias Zuniga, P.J. Keir, J.R. Potvin, M.J. Gibala. McMaster University, Canada. E460 707.8 Single Bout of Moderate-Intensity Exercise Facilitates Memory Consolidation via New Protein Synthesis in Dorsal Hippocampal CA. K. Inoue, A. Yamaguchi, I. Morita. Health Sciences University of Hokkaido, Japan. E461 707.9 Effects of the Different Acute Exercise on Melatonin of Undergraduate. Y. Sun, J. He, L. Qiu. East China Normal University, People’s Republic of China. E462 707.10 PGC-1α–Dependent TFEB Expression and Activation with Exercise. A.T. Erlich, D. Brownlee, K. Beyfuss, D. Hood. York University, Canada. E463 707.11 Dynamics of Locomotor Fatigue During SupraCritical Power Exercise in Humans. A. Swisher, B. Koehn, S. Yong, J. Cunha, C. Ferguson, D.T. Cannon. San Diego State University and University of Leeds, United Kingdom. E464 707.12 Factors Predictive of Human One-Kilometer Ice Swimming Race Time Performance. C.A. Wulf, S.P. Treu, T. Wilson. Winona State University. E465 707.13 Active Video Gaming Compared to Treadmill Walking and TV Watching in Obese Children and Adolescents. W. Smith, R.A. Moran, C.A. Fu, T.A. Scott. University of Tennessee Health Science Center and LeBonheur Children’s Hospital.
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E466 707.14 Predicting Mountain Ultra-Marathon Performance Using the Critical Velocity Model. M. Rogers, M. Ngo, O. Sandberg, P. Atashzay, P. Singh, C. Malcolm, D. Clarke, M. Walsh, M. White. Simon Fraser University, Canada. E467 707.15 Does Maximal Isokinetic Power at Exercise Intolerance Approximate Critical Power? S. Yong, A. Swisher, C. Ferguson, D.T. Cannon. San Diego State University and University of Leeds, United Kingdom. E468 707.16 Aortic Pulsatility and Arterial Stiffness After Acute Combined Resistance and Endurance Exercise. T.R. Wakeham, I.M. Greenlund, J.J. Durocher. Michigan Technological University. E469 707.17 Exercise-Induced Expression, Function, and Localization of Protein Arginine Methyltransferases in Skeletal Muscle. T.L. van Lieshout, D.W. Stouth, V. Ljubicic. McMaster University, Canada.
708. AUTONOMIC ADJUSTMENTS TO EXERCISE Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E470 708.1 Blunted Autonomic Response to Head Up Tilt in Individuals with Intellectual Disabilities: Preliminary Results. T. Hilgenkamp, E.C. Schroeder, D.W. White, T. Baynard, B. Fernhall. University of Illinois at Chicago, Erasmus MC University Medical Center Rotterdam, Netherlands and University of Houston-Victoria. E471 708.2 Pedometer-Determined Physical Activities of Daily Living Can Affect Blood Pressure Regulation in Healthy Young Adults After Postural Change. H. Yang, Y. Kotaki, J. Hoshi, S. Bao, H. Tanno, E. Kanno, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E472 708.3 Exercise Training Intolerance in Heart Failure with Preserved Ejection Fraction Is Associated with Altered Chemoreflex Gain and Sympathoexcitation in Rats. D.C. Andrade, A. Arce-Alvarez, C. Toledo, H. Diaz, C. Lucero, M. Faundez, R. Iturriaga, R. Del Rio. Pontificia Universidad Catolica de Chile, Chile and Universidad Autonoma de Chile, Chile. E473 708.4 Combined Exercise Training Atenuates the Onset of Cardiometabolic and Autonomic Dysfunctions in an Experimental Model of Metabolic Syndrome. D. Dias, N. Bernardes, F.F. Conti, J.d. Brito, F. Santos, A.A. Araujo, D.M. Oliveira, N. Frisene, M. Irigoyen, K. De Angelis. Universidade Nove de Julho, Brazil and Medical School of University of Sao Paulo, Brazil. E474 708.5 Muscle Sympathetic Nerve Responses to Passive and Active One-Legged Cycling: Insight Into the Contributions of Central Command. C.J. Doherty, A.V. Incognito, K. Notay, M.J. Burns, M. Nardone, J.D. Seed, P.J. Millar. University of Guelph, Canada and University of GuelphHumber, Canada.
SUNDAY PHYSIOLOGY E475 708.6 Linear and Nonlinear Analysis of Heart Rate Variability in an Experimental Model of Diabetes and Obesity Submitted to Myocardial Infarction: Role of Aerobic Exercise Training. F.F. Conti, M. Sartori, F. Santos, D.S. Dias, J.F. Machi, L.E. Souza, Jensen, M. Morris, M. Irigoyen, K. De Angelis. Universidade Nove de Julho, Brazil, Universidade of São Paulo, Brazil and Nova Southeastern University. E476 708.7 Autonomic Cardiovascular Response During the Isometric Cuban Test of the Sustained Weight. M. SanchezHechavarria, R. Carrazana-Escalona, B. Ricardo-Ferro, I. Cutino-Clavel, E. Lopez-Galan. University of Santiago de Cuba, Cuba. E477 708.8 Inter-Individual Variability in Muscle Sympathetic Nerve Activity During Static Handgrip in Healthy Young Men. A.V. Incognito, C.J. Doherty, J.B. Lee, M.J. Burns, P.J. Millar. University of Guelph, Canada.
709. ALTITUDE AND HYPOXIA AND RESPIRATORY RESPONSES TO EXERCISE Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E478 709.1 Withdrawn. E479 709.2 Altered Hypoxia-Induced Vascular Reactivity and Endothelial Repair Capacity in Hypertensive Men. H.N. Rocha, V.P. Garcia, J.D. Mattos, M.P. Rocha, M.O. Campos, D.E. Mansur, A.L. Nóbrega, I.A. Fernandes, N.G. Rocha. Fluminense Federal University, Brazil. E480 709.3 Acute Hypoxia Decreases Systemic Blood Pressure at Exercise in Hypertensive and Normotensive Subjects. J. Richalet, L. Winkler, F.J. Lhuissier. Université Paris 13, Sorbonne Paris Cité and, France. E481 709.4 Higher Protein Diet Suppresses Appetite at High Altitude. J. Karl, R.E. Cole, C.E. Berryman, M.T. Kominsky, P.N. Radcliffe, L.M. Margolis, A.J. Young, S.M. Pasiakos. US Army Research Institute of Environmental Medicine and Oak Ridge Institute of Science and Education. E482 709.5 Molecular Basis of Hypoxia Induced Excessive Erythrocytosis. P. Azad, G. Haddad. University of California San Diego. E483 709.6 Poincare Analysis of Spontaneous Respiratory Sinus Arrhythmia During High Altitude Ascent: Effects on Oxygenation. G. Saran, L. Lavoie, A. Linares, J. Pfoh, C. Bruce, K. Borle, R. Brandt, K. Tjandra, T.A. Day. Mount Royal University, Canada. E484 709.7 Effects of Transitioning from Un-Occluded to Occluded Hyperbolic Submaximal Exercise on VO2 Mean Response Time and Oxygen Deficit. E.H. Van Iterson, T.P. Olson. Mayo Clinic. E485 709.8 Habitual Physical Activity Level Modifies Lung Function, but Not 8-Isoprostane Generation, in Older Adults. S.P. Kurti, S.R. Emerson, S.K. Rosenkranz, J.R. Smith, C.A. Harms. Kansas State University. E486 709.9 Imposed Expiratory Resistance, Hyperinflation, and Dyspnea Are Dissociated from Locomotor Fatigue During Moderate Exercise. B.E. Wickman, K.G. Sasaki, E. TorrecillasSanchez, D.T. Cannon. San Diego State University.
710. MUSCLE PHYSIOLOGY: REGULATION OF CONTRACTION, OXIDATIVE STRESS AND OXYGEN DELIVERY Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E487 710.1 Determinants of Skeletal Muscle Work Efficiency in Patients with COPD. G. Layec, C.R. Hart, J. Trinity, Y. Le Fur, E. Jeong, R. Richardson. University of Utah and University of Aix-Marseille, France. E488 710.2 Muscle Recruitment Patterns Above Critical Power. A.M. Alexander, S.M. Hammer, K.D. Didier, D.R. Baumfalk, T.J. Barstow. Kansas State University. E489 710.3 Active Shortening Protects Against StretchInduced Force Deficits in Human Skeletal Muscle. A.L. Saripalli, K.B. Sugg, C.L. Mendias, S.V. Brooks, D.R. Claflin. University of Michigan. E490 710.4 Myosin Phosphorylation-Mediated Potentiation Does Not Alter the Economy of Work Performed in Fast Skeletal Muscles. W. Gittings, J. Bunda, R. Vandenboom. Brock University, Canada. E491 710.5 Increased Superoxide Dismutase-2 in Skeletal Muscle in a Rat Model of Preterm Birth. E.S. Hokanson, L. Tetri, R.K. Braun, M.W. Eldridge. University of WisconsinMadison and UW Madison. E492 710.6 Human Skeletal Muscle Proteins and Metabolic Pathways Are Susceptible to Dicarbonyl Stress. J.T. Mey, J.M. Haus. University of Illinois at Chicago. E493 710.7 Muscle Inflammatory Signaling’s Contribution to Cancer Cachexia-Induced Decrements in Muscle Function. B. VanderVeen, J. Hardee, D. Fix, J. Carson. University of South Carolina. E494 710.8 Short Term High Fat Feeding Alters Expression of Glucoregulatory Proteins in Skeletal Muscle of Male Adolescent Rats. M.S. Crawford, T. Liss, K. Sweazea. Arizona State University. E495 710.9 Whole Body Hyperthermia Enhances Angiogenesis in Tenotomized Rat Skeletal Muscle. M. Hirunsai, R. Srikuea. Srinakharinwirot University, Thailand and Mahidol University, Thailand. E496 710.10 Metabolic Demand Dictates Muscle Blood Flow and the Hyperemic Response to Low Intensity Exercise. A. Tonson, J. Kasper, D. Tanbakuchi, R. Meyer, R. Wiseman. Michigan State University. E497 710.11 Nitrite Infusion Does Not Alter Isolated Canine Muscle Oxidative Metabolism in Situ During Hypoxia with Normal Convective O2 Delivery. S. Porcelli, L. Rasica, B.S. Ferguson, A.N. Kavazis, J.R. McDonald, F. Mowry, M.C. Hogan, B. Grassi, B.L. Gladden. National Research Council, Italy, University of Milan, Italy, Italian National Research Council, Italy, University of Illinois, Auburn University, University of California San Diego and University of Udine, Italy.
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711. REDUCED GRAVITY AND HYPERBARIC ENVIRONMENTS Poster
Poster
(Sponsored by: APS Environmental and Exercise Physiology Section)
(Sponsored by: APS Environmental and Exercise Physiology Section)
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:45 pm–3:00 pm
Presentation time: 12:45 pm–3:00 pm
E498 711.1 Carotid Artery Structure During and After Long-Duration Space Flight. S.M. Lee, D.S. Martin, S.S. Laurie, L.C. Ribeiro, S.M. Smith, S.R. Zwart, M.B. Stenger. KBRwyle, NASA Johnson Space Center and University of Texas Medical Branch. E499 711.2 Development of a Chronic Irradiation and Simulated Microgravity Facility. P. Chowdhury, R.J. Griffin, G. Narayanasamy, R. Pathak, M. Hauer-Jensen, M. Boerma, M. Dobretsov. University of Arkansas for Medical Science. E500 711.3 Hindlimb Suspension as a Model for Intracranial and Intraocular Pressures, and Retinal Changes During Spaceflight. C.A. Fuller, H. Gompf, T. Hoban-Higgins, E. Robinson. University of California at Davis. E501 711.4 High Air-Pressure Elevated Energy Expenditure in Mice. D. Xiang, Y. Fang, B. Luo, S. Yan, J. Xu, P. Chen. Naval Medical Research Institute, People’s Republic of China, and Shanghai University of Sport, People’s Republic of China. E502 711.5 Singlet Oxygen Production in the Caudodorsal Medulla of Rat Brain Slices Increases During Hyperoxia at Normobaric Pressure and Following Decompression from IsoOxic Hyperbaric Nitrogen. T.R. Roberts, G.E. Ciarlone, J.B. Dean. University of South Florida and US Army Institute of Surgical Research. E503 711.6 Reevaluation of CNS Oxygen Toxicity Seizures in Male Sprague-Dawley Rats. C.M. Hinojo, N.M. Stavitzski, C.S. Landon, J.B. Dean. University of South Florida. E504 711.7 Investigating the Effects of Hyperbaric Oxygen on Mitochondrial Function of Endothelial Progenitor Cells. N. Aylin-Burns, K.J. Krager, D. Zhou, M. Hauer-Jensen. University of Arkansas for Medical Sciences. E505 711.8 Can Hyperoxia and Hyperbaric Conditions Induce a Increase in Systemic Pressures (SBP, DBP, MAP) to the Breathing of 100 Percent Oxygen at Normal and Hyperbaric Barometric Pressure? A. Duvallet, E. Duvallet, F. Lhuissier, P. Constantin, M. Beaudry. Hopital Avicenne, APHP, Paris, France, VeroScience, Sorbonne-Paris-Cité, Université Paris 13, France, Hôpital Avicenne, APHP, Paris, France, Metropolitan and CMA Marseille-Aubagne, France.
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712. NEURAL CONTROL OF THE CIRCULATION DURING EXERCISE
E506 712.1 Passive Heating Impairs Cardiac Autonomic Regulation During Exercise and Post-Exercise Recovery. T. Peçanha, C. Forjaz, D. Low. University of Sao Paulo, Brazil and Liverpool John Moores University, United Kingdom. E507 712.2 Lumbar Sympathetic Nerve Activity at Rest and During Muscle Contraction: Effects of Estrogen and Nitric Oxide. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E508 712.3 Estrogen and Neuronal Nitric Oxide-Mediated Inhibition of Sympathetic Vasoconstriction. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E509 712.4 Sex Differences in Sympathetic Vasoconstrictor Responsiveness and Sympatholysis. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E510 712.5 Role of Alpha-Adrenergic Vasoconstriction in Regulating Skeletal Muscle Blood Flow During Single Leg Knee Extension Exercise with Advancing Age. S.M. Ratchford, H.L. Clifton, Z.M. Barret-O’Keefe, R.M. Broxterman, J.R. Gifford, J.R. Hydren, M.J. Rossman, S.J. Ives, J.D. Trinity, M.A. Witman, R.S. Garten, D.E. Morgan, A.D. Nelson, R.S. Richardson, D.W. Wray. University of Utah and VA Medical Center. E511 712.6 Functional Sympatholysis Is Impaired in EndStage Renal Disease. R. Downey, H. Lee, P. Liao, D. DaCosta, J. Park. Emory University and Atlanta VA Medical Center. E512 712.7 The Role Played by Oxidative Stress in Evoking the Exercise Pressor Reflex in Health and Simulated Peripheral Artery Disease. J.E. Harms, J.S. Kim, J.M. Kuczmarski, G.D. Thomas, M.P. Kaufman. Penn State University College of Medicine. E513 712.8 Revisiting “Resetting” of Baroreflexes During Canine Exercise. R.D. Wurster. Loyola University Chicago. E514 712.9 Effect of Endurance Training on the Centrally Induced Muscle Vasodilatation During One-Legged Cycling. R. Asahara, K. Matsukawa, T. Shintaku. Hiroshima University, Japan. E515 712.10 Early Stage Type 1 Diabetes Augments the Mechanoreflex in Rats. E.A. Garcia, A. Grotle, A.J. Stone. University of Texas at Austin. E516 712.11 Similar Effects of Type 1 Diabetes on the Pressor Reflex in Male and Female Rats. A. Grotle, E.A. Garcia, A.J. Stone. University of Texas at Austin. E517 712.12 Effects of Type 1 Diabetes on the Exercise Pressor Reflex in Rats. A.J. Stone, A. Grotle, E.A. Garcia, M.L. Harrison. University of Texas at Austin. E518 712.13 Exaggerated Sympathetic and Pressor Responses to Exercise Pressor Reflex Activation Are Attenuated by Intracerebroventricular Insulin Administration in Type 2 Diabetic Rats. M. Mizuno, J. Mitchell, S.A. Smith. UT Southwestern Medical Center.
SUNDAY PHYSIOLOGY E519 712.14 ATP-Sensitive K+ Channel Inhibition via Glibenclamide Does Not Increase Lumbar or Renal Sympathetic Nerve Discharge in Healthy Rats. T.D. Colburn, C.T. Holdsworth, J.C. Craig, D.M. Hirai, S. Montgomery, M.J. Kenney, T.I. Musch, D.C. Poole. Kansas State University. E520 712.15 Chronic Femoral Artery Ligation Exaggerates the Exercise Pressor Reflex But Not Selective Activation of the Muscle Mechanoreflex in Decerebrate Rats. K.S. Rollins, P.J. Esau, S.W. Copp. Kansas State University. E521 712.16 Contribution of Prostaglandins to the Inspiratory Muscle Metaboreflex-Induced Cardiovascular Consequences. J.R. Smith, K.D. Didier, S.M. Hammer, A.M. Alexander, S.P. Kurti, T.J. Barstow, C.A. Harms. Kansas State University. E522 712.17 Rna-Sequence Analysis Reveals Unique Changes in the Dorsal Root Ganglia Transcriptome of Rats with Femoral Artery Occlusion. J.M. Kuczmarski, K. Unrath, Y. Imamura, G.D. Thomas. Penn State College of Medicine. E523 712.18 Expression and Distribution of ProInflammatory Cytokines Within Dorsal Root Ganglion of Rats with Femoral Artery Occlusion. J. Li, J. Lu, J. Xing. Penn State College of Medicine, The First Hospital of Jilin University, Jilin University, People’s Republic of China. E524 712.19 The Postexercise Pressor Reflex Is Influenced by Pedal Frequency During Low Intensity Ergometry in Normotensive Healthy Adults. N.R. Randall, E.H. Van Iterson, N. Villarraga, B. Ziegler, T.P. Olson. Mayo Clinic. E525 712.20 Combined Influences of Subsystolic Regional Circulatory Occlusion and Pedal Rate on the Exercise Pressor Reflex in Healthy Adults. N. Villarraga, E.H. Van Iterson, N. Randall, B. Ziegler, T.P. Olson. Mayo Clinic.
713. THE EFFECTS OF AGING ON MUSCLE FUNCTION Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E526 713.1 AdipoRon, Pan-Adiponectin Receptor Agonist, Activates Mitochondrial Metabolism via AMPK-PGC1α Pathway in the Skeletal Muscle. P. Balasubramanian, P. Howell, S. Martin, R. Anderson. University of Wisconsin-Madison. E527 713.2 Estradiol Deficiency Leads to High miR21 Level in Skeletal Muscle of Ovariectomized Mice. S.M. Karvinen, E. Laakkonen, G. Le, B.C. Collins, T.L. Mader, D. Lowe. University of Jyväskylä, Finland and University of Minnesota. E528 713.3 Dietary Nitrate and Skeletal Muscle Recovery After Injury in Young and Old Mice. D. Hahn, R. Patel, R.C. Kelley, P.D. Coblentz, L.F. Ferreira. University of Florida. E529 713.4 Muscle-Specific Calpastatin Overexpression Prevents Sarcopenia of Aging. E.A. Schroder, X. Song, L. Wang, G.S. Supinski, L. Callahan. University of Kentucky. E530 713.5 Age-Related Alterations in Cutaneous Vascular and Sweating Responses Depend on Sex and Types of Receptor Agonist. N. Fujii, B.D. McNeely, L. Halili, S.Y. Zhang, M.O. Danquah, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan.
E531 713.6 The Effects of Low-Intensity Exercise During Bed Rest in Healthy Older Adults. F. Galvan, E. ArentsonLantz, S. Nagamma, R.R. Deer, C.S. Fry, A. Wacher, D. Paddon-Jones. University of Texas Medical Branch (UTMB). E532 713.7 PGC-1α Upregulates Mitochondrial Sirtuins and Reduces Protein Acetylation in Skeletal Muscle of Old Mice. C. Kang, D. Yeo, L. Ji. University of Minnesota-Twin Cities and University of Minnesota. E533 713.8 Testing the Efficacy of β-Hydroxy-βMethylbutyrate (HMB) to Preserve Mitochondrial Function in Aging Drosophila melanogaster. D.M. Callahan, A.F. Mead, D.W. Maughan. University of Vermont. E534 713.9 p16 and γH2AX as Markers of Cellular Senescence in Young and Old Human Skeletal Muscle. C. Dungan, K. Kosmac, B. Peck, J. McCarthy, C. Peterson. University of Kentucky. E535 713.10 Satellite Cell-Mediated Myonuclear Accretion Is Required for Mechanical Overload-Induced Hypertrophy in Young Growing Mice. K. Murach, S. White, Y. Wen, A. Ho, K. Kosmac, J. McCarthy, C. Peterson. University of Kentucky. E536 713.11 Parkin Overexpression Attenuates AgingRelated Muscle Atrophy in Mice. O. Reynaud, J. LeducGaudet, S.N. Hussain, G. Gouspillou. Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Canada, UQAM, Canada, Groupe de Recherche en Activité Physique Adaptée, Canada, Meakins-Christie Laboratories, Departement of Critical Care, Canada and Research Institute of the McGill University Health Centre, Canada. E537 713.12 Sestrin 2 and 3 Gene Expressions Correlate with Homeostasis Model Assessment of Insulin Resistance and Beta Cell Secretory Status in Older Men. N. Zeng, P. Sharma, F. Ramzan, S.M. Mitchell, R.F. D’Souza, U. Prodham, A.M. Milan, C.J. Mitchell, D. Cameron-Smith. University of Auckland, New Zealand. E538 713.13 Fn14 Expression Is Lower in Female Compared to Male Skeletal Muscle, Independent of Adult Age. J. Blum, H. Roman, A. Thalacker-Mercer. Cornell University.
714. NEUROENDOCRINOLOGY, HYPOTHALAMUS AND PITUITARY Poster (Sponsored by: APS Endocrinology and Metabolism Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E539 714.1 Exploring the Role of Pituitary Kisspeptin Receptor on Gonadotrophic Function in Vivo and in Vitro. O. Awe, Y. Ma, A. Wolfe. Johns Hopkins School of Medicine, Affiliated Hospital of Jiangnan University, People’s Republic of China. E540 714.2 Aberrant Light-Induced Depression Is Associated with Decreased Adult Hippocampal Neurogenesis in Mice. L.J. Massman, W.C. Engeland, P. Kofuji. University of Minnesota. E541 714.3 Identification of a Novel Regulator of Vasopressin Secretion. L.M. Stein, J. Soo, S. Loewen, C. Hindmarch, A. Ferguson, G. Yosten, W. Samson. Saint Louis University, University of Pennsylvania and Queens University, Canada.
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PHYSIOLOGY SUNDAY E542 714.4 Copeptin: More Than Just a Surrogate Biomarker. C.J. Haddock, H.M. Wille, G.L. Yosten, W.K. Samson. Saint Louis University. E543 714.5 Hypothalamic Pathways Involved in Adenosine A1 Receptor Agonist-Induced Hibernation in the Arctic Ground Squirrel (Urocitellus paryii). C. Frare, K.L. Drew. University of Alaska Fairbanks.
715. PANCREATIC HORMONES, GLUCOSE HOMEOSTASIS, AND DIABETES Poster (Sponsored by: APS Endocrinology and Metabolism Section)
716. DIABETIC RENAL DISEASE Poster (Sponsored by: APS Renal Section)
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:45 pm–3:00 pm
Presentation time: 12:45 pm–3:00 pm
E544 715.1 Determining the Role of CEBP/α in Functional β-Cell Mass. K.B. Kener, J.D. Ray, M. Ballard, W. Utsch, J.S. Tessem. Brigham Young University. E545 715.2 Proinsulin C-Peptide Effects in Retinal Pigment Epithelium Health and VEGF Release: Implications for Diabetic Retinopathy. S.M. Grote, G.R. Kolar, G.L. Yosten. Saint Louis University School of Medicine. E546 715.3 The Cellular Response to C-Peptide Is Dependent on the Concentration of Glucose and Insulin. J.L. Rossiter, G.R. Kolar, G.L. Yosten. St Louis University. E547 715.4 Knockout of miR-223 Induces Beta-Cell Dysfunction Through Activation of the FOXO1 Signaling Pathway. Y. Li, J. Peng, S. Deng, X. Wang, D. Kuhel, J. Cash, K. Essandoh, X. Mu, E. Salem, D. Hui, G. Fan. University of Cincinnati. E548 715.5 Orphan Nuclear Hormone Receptor Small Heterodimer Partner Plays a Protective Role in Diet-Induced Islet Dysfunction. J. Park, M. Lee, Y. Lee. Northeast Ohio Medical University. E549 715.6 Free Fatty Acid Receptor 3 Plays a Role in High Fat Diet Induced β Cell Dysfunction and β Cell Stress. M. Priyadarshini, A.E. Ludvik, C. Cole, M. Newman, B.T. Layden. University of Illinois at Chicago, Northwestern University and Jesse Brown Veterans Affairs Medical Center. E550 715.7 Cytokines Activate Src Kinase and Inhibit EGFR-Mediated Repair Mechanisms via Mig6 in Pancreatic Beta Cells. K.M. Fong, A. Rezaeizadeh, Y. Chen, P.T. Fueger. Indiana University School of Medicine and City of Hope. E551 715.8 Low Phosphorus Diet Enhances Insulin Sensitivity. Y. Lin, L. Berger, Z. Sun. University of Oklahoma HSC. E552 715.9 Short-Term Metformin and Exercise Training Effects on Strength, Aerobic Capacity, Glycemic Control and Mitochondrial Function in Burn Children. E. Rivas, C. Porter, D.N. Herndon, O.E. Suman. The University of Texas Medical Branch and Shriners Hospitals for Children. E553 715.10 AICAR Attenuates Olanzapine-Induced Hyperglycaemia and Insulin Resistance in C57BL6 Mice. N. Bush, L. Castellani, D.C.Wright. University of Guelph, Canada. E554 715.11 Hypomagnesemia in Type 2 Diabetes Is Correlated with Insulin Resistance and Changes in Lipid Metabolism in Patients and Mice. S. Kurstjens, J. de Baaij, J. van Diepen, C. Overmars-Bos, H. Bouras, R. Bindels, C. Tack, J. Hoenderop. Radboudumc Nijmegen, Netherlands.
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E555 715.12 Hepatic Androgen Receptor Modulates Hyperandrogenemia-Induced Glucose Metabolic Dysfunction and Hepatic Insulin Resistance. S. Andrisse, S. Wu. Johns Hopkins University School of Medicine. E556 715.13 Raw Garlic Aqueous Extract (RGAE) Augments MafA Expression in the Liver of STZ-Induced Type-1 Diabetic Rats. K.K. Al-Qattan, A. Al-Otaibi, A. Al-Adsani, M. Al-Bader, M. Thomson, S.J. Divya, L. Miranda, S. Al-Bustan. Kuwait University, Kuwait.
E557 716.1 Effect of Resistance Exercise Training in Mitophagy of Diabetic Rats. l. Jorge, K.A. Silva, R.S. Luiz, R.R. Rampaso, N. Schor. Federal University of Sao Paulo, Brazil. E558 716.2 Modeling the Effects of Functional Adaptation to Reduction in Renal Mass. A. Layton, A. Edwards, V. Vallon. Duke University, Boston University and University of California San Diego. E559 716.3 In Vivo Knockdown of I-mfa Using the Targeted Nanoparticle Delivery System Ameliorated Renal Injury in Diabetic Mice. Y. Ma, W. Li, H. Jiang, Y. Wang, J. Zuckerman, M. Davis, R. Ma. University of North Texas Health Science Center, Anhui Medical University, People’s Republic of China, and California Institute of Technology. E560 716.4 Renal Olfactory Receptor 1393 May Contribute to the Progression of Diabetic Nephropathy. B.D. Shepard, J.L. Pluznick. Johns Hopkins University School of Medicine. E561 716.5 Polyphenolics Protect Renal Fibroblasts from the Harmful Effects of Hyperglycemia-Stimulated Advanced Glycation End Products. J.M. Harris, M.A. Blount. Emory University School of Medicine. E562 716.6 GYY4137 Modulates Plasminogen Activator Inhibitor-1-Dependent Extracelluar Matrix Turnover in Diabetic Kidney via RAR/RXR Signaling. A. Papu John, S. Pushpakumar, U. Sen. University of Louisville. E563 716.7 Fibroblast Growth Factor 1 Ameliorates Diabetic Nephropathy Through an Anti-Inflammatory Mechanism. Q. Lin, L. Cai, Y. Tan. University of Louisville. E564 716.8 Up-regulation of Transforming Growth FactorBeta via Advanced Glycation End Products-Induced Oxidative Stress on NRK-52E Cells. S. Jeong, S. Yang, K. Lee. Korea University, Republic of Korea. E565 716.9 Nox 4 Null Mutation Attenuates Podocyte Calcium Regulation Dysfunction and Kidney Damage in Streptozotocin-Treated Dahl Salt-Sensitive Rats. G. Blass, D. Ilatovskaya, K. Winsor, V. Levchenko, O. Palygin, A.W. Cowley Jr., A. Staruschenko. Medical College of Wisconsin. E566 716.10 Biomarkers of Kidney Injury and Indicators of Renal Inflammation in African American Men with Diabetes and Diabetic Nephropathy. L. Premadasa, A.M. Boston, R. Sedighi, G.E. Crawford, J. Pinder, O.E. Jegede, S.H. Harrison, R.H. Newman, E.M. Ongeri. North Carolina A&T State University and Cone Health Community Health and Wellness Center.
SUNDAY PHYSIOLOGY E567 716.11 Transcriptional Regulation and Therapeutic Targeting of P2X7 Receptors in Diabetic Nephropathy. R.I. Menzies, J.W. Booth, J.J. Mullins, M.A. Bailey, F.W. Tam, J.T. Norman, R.J. Unwin. University of Edinburgh, United Kingdom, UCL, United Kingdom and Imperial College London, United Kingdom. E568 716.12 Correlations Between Biomarkers of Kidney Injury, Adiponectin, and TGF?β1 in African American Men with Diabetes. A.M. Boston, L.S. Premadasa, R. Sedighi, G. Crawford, J. Pinder, S. Whitaker, O.E. Jegede, S.H. Harrison, R.H. Newman, E.M. Ongeri. North Carolina A&T State University and Cone Health Community Health and Wellness Center. E569 716.13 Suppression of Albumin-Induced Matrix Metalloproteinase-9 by Rosiglitazone in Renal Tubular Epithelial Cells. A. Cobbs, X. Chen, A. Khamdy, A. Chima, J. George, X. Zhao. Morehouse School of Medicine. E570 716.14 MicroRNA-21 Ablation Exacerbates Aldosterone-Mediated Renal Injury. S.L. Njemanze, M. Syed, L. Ramachandran Nair, J.P. Ball, K.W. Mathis, M.J. Ryan, M.E. Rothenberg, L.L. Yanes Cardozo, D.G. Romero. University of Mississippi Medical Center and Cincinnati Children’s Hospital. E571 716.15 Novel Differences in Renal Gene Expression in a Diet Induced Obesity Model of Diabetic Nephropathy. V.L. Halperin Kuhns, J.L. Pluznick. Johns Hopkins University. E572 716.16 Metformin Normalises Medullary Hypoxia in the Diabetic Rat Kidney. M. Christensen, T. Schiffer, R. Nørregaard, F. Palm. Aarhus University, Denmark and Uppsala University, Sweden.
717. AUTONOMIC ADJUSTMENTS TO BEHAVIORAL STRESS AND NEUROENDOCRINE ACTIVATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E573 717.1 Preproglucagon Neurons in the Brainstem Regulate Glucose Homeostasis and Insulin Sensitivity. X. Shi, S. Chacko, A. Brown, D. Li, F. Li, X. Guan. Baylor College of Medicine, Binzhou Medical University Hospital, People’s Republic of China, and the University of Texas MD Anderson Cancer Center. E574 717.2 Effects of Catecholamines on Gastric Functions in Stressed Rats. Y. Jiang, K.N. Browning, L. Toti, R. Travagli. Penn State College of Medicine. E575 717.3 A Ventral Medial Prefrontal Cortex– Dorsomedial Hypothalamus Monosynaptic Pathway That Drives Sympathetic Stress Responses. N. Kataoka, K. Nakamura. Nagoya University Graduate School of Medicine, Japan and JST, Japan. E576 717.4 The Relaxation Effects of Hand-Massage Therapy on Autonomic Nervous System Function and Emotions: Increases in Eye Contact and Communication. T. Sato, S. Bao, J. Hoshi, H. Yang, H. Tanno, E. Kanno, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E577 717.5 Method for Simultaneous Measurement of Amygdala Neuronal and Sympathetic Nerve Activity in Freely Moving Rats. K. Shizuka, M. Yoshimoto, F. Ootsuki, K. Miki. Nara Women’s University, Japan.
E578 717.6 Four Weeks of Exposure to Environmentally Relevant Levels of Second Hand Smoke Decreases Heart Rate Variability—but Not Baroreflex Sensitivity—in Mice. E. Karey, S. Pan, Y. Chen, K.E. Pinkerton, C. Chen. UC-Davis. E579 717.7 Pressor Hyperreactivity to Stress Corresponds to Greater Vasoconstriction and Sympathetic Responsiveness and Is Prevented by Renal Denervation. M.M. Knuepfer, S.K. Burris, J.L. Perry. St. Louis University School of Medicine, St. Louis University, Loyola University Strich School of Medicine and St. Louis University School Medicine.
718. ION CHANNEL MODULATION: CONTRIBUTIONS TO AUTONOMIC DYSFUNCTION IN CARDIOVASCULAR AND METABOLIC DISEASES? Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E580 718.1 Chronic Hypertension Switches IrritantInduced Pulmonary-Cardiac Reflexes to Sympathoexcitation. T. Taylor-Clark, J.S. Hooper. University of South Florida. E581 718.2 Neuronal Nitric Oxide Synthase Inhibits StoreOperated Ca2+ Entry in Cardiomyocytes via S-Nitrosylation of Stromal Interaction Molecule-1. Q. Feng, L. Gui, J. Zhu, X. Lu, S.M. Sims, W. Lu, P.B. Stathopulos. University of Western Ontario, Canada, Nantong University Medical School, People’s Republic of China. E582 718.3 Hydrogen Peroxide Inhibits Neurons in the Paraventricular Nucleus of the Hypothalamus. D.D. Kline, M.P. Matott. University of Missouri. E583 718.4 Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling in Cardiac Postganglionic Parasympathetic Neurons During the Progression of Heart Failure After Myocardial Infarction. D. Zhang, H. Tu, C. Wang, R. Muelleman, M. Wadman, Y. Li. University of Nebraska Medical Center, First Affiliated Hospital of Xi’an Jiaotong University, People’s Republic of China. E584 718.5 Small-Conductance Ca2+-Activated K+ (SK) Channels Regulate Pre-Sympathetic Neurons in the Hypothalamic Paraventricular Nucleus (PVN) and Parasympathetic Cardiomotor Neurons (CMN) in the Nucleus Ambiguus (NA): Pathological Changes. Z. Cheng, M. Lin, G.M. Toney, Q. Chen. College of Medicine, University of Central Florida, University of Texas Health Science Center at San Antonio and Michigan Technological University. E585 718.6 Inflammation and Impaired α2-Adrenergic Receptor-Mediated Inhibition of Ca2+ Channels Contribute to Hypertension in DOCA-Salt but Not Obese Dahl SS Rats. R.K. Mui, R.N. Fernandes, H.G. Garver, G.D. Fink, H. Xu, J.J. Galligan. Michigan State University. E586 718.7 Noisy Timing of Nicotinic Synaptic Activity Promotes Amplification in Sympathetic Ganglia. J.P. Horn, P.H. Kullmann. University of Pittsburgh. E587 718.8 The Role of the Mechanosensitive Renal Sensory Afferent Nerve Sympathoinhibitory Reno-Renal Reflex in Sympathetic Outflow, Natriuresis, and Blood Pressure Regulation. A. Frame, R. Wainford. Boston University.
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PHYSIOLOGY SUNDAY E588 718.9 GABA and Glycine: Fine Tuning for Inhibitory Control of Brainstem RVLM Neurons. H. Gao, A. Derbenev. Tulane University. E589 718.10 High Salt Intake Induces Sympathetic Activation in Dahl Salt-Sensitive Rats Through Activation of Orexin-TNF Signaling in the Hypothalamic Paraventricular Nucleus (PVN). E. Jiang, M. Huber, Y. Fan, F. Zhu, Q. Chen, Z. Shan. Michigan Technological University, Institute of Public Hygiene, People’s Republic of China. E590 718.11 Maternal Treatment of Renovascular Hypertensive Rats with Hydrogen Sulfide Inhibited Hypertension in Offspring. Y. Wu, Q. Guo, X. Feng, H. Xue. Hebei Medical University, People’s Republic of China.
719. SCHOLANDER POSTER SESSION Poster (Sponsored by: APS Comparative and Evolutionary Physiology) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F1 719.1 Involvement of Serotonergic Neurons in the Ventilatory Response to Hypercapnia in Birds (Chicken, Gallus gallus). K.M. Santos, S.B. Abreu, G.M. Garcia, K.C. Bícego, L.H. Gargaglioni, G.S. da Silva. Sao Paulo State University UNESP-FCAV, Brazil. F2 719.2 Diving Mice vs. Torpid Mice: A Comparison of Cardiovascular Regulation. E.M. Hult, M.J. Bingaman, S.J. Swoap. Williams College. F3 719.3 Insulin Resistance in Horses Varies Throughout the Year and Among Breeds. C.N. Moffatt, Z.W. Paquin, A. Guild, K.M. Johnson. Beloit College and Elkhorn Veterinary Clinic. F4 719.4 Autonomic Control of Thermogenic Capacity Is Optimized in Deer Mice Native to High or Low Altitudes. O.H. Wearing, K.B. Tate, G.R. Scott. McMaster University, Canada and Truman State University. F5 719.5 Expression and Function of an Animal MEP/ Amt Ammonia Transporterm, AeAmt2 in the Larvae of the Mosquito, Aedes aegypti. A.C. Durant, A. Donini. York University, Canada. F6 719.6 Antibodies Against Sodium-Dependent Cation Chloride Cotransporters in the Yellow Fever Mosquito Aedes aegypti. K.C. Viel, A.C. DeBrosse, G.F. Riley, P.M. Piermarini, C.M. Gillen. Kenyon College and The Ohio State University. F7 719.7 Do Ion-Motive Pumps Contribute to ColdAcclimation in Drosophila? G. Yerushalmi, H. MacMillan, A. Donini. York University, Canada. F8 719.8 Temperature Effect on Cardiorespiratory Responses and Autonomic Modulation of Heart Rate in Premetamorphic Bullfrog Tadpoles, Lithobates catesbeianus. L.S. Longhini, L.A. Zena, G.S. da Silva, K.C. Bícego, L.H. Gargaglioni. Sao Paulo State University, Brazil. F9 719.9 Temperature-Induced Changes to Aquaporin Localization in the Freeze-Tolerant Cope’s Gray Treefrog. B. Stogsdill, J. Frisbie, C. Krane, D. Goldstein. Wright State, Wright State University and University of Dayton. F10 719.10 Neuromuscular Inactivity of the Respiratory Control System During Overwintering in Bullfrogs, Lithobates catesbeianus. J.M. Santin, L. Hartzler. Wright State University.
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F11 719.11 RNA-Seq Analysis of the Effects of ColdAcclimation and Freezing on the Hepatic Transcriptome in the Freeze-Tolerant Cope’s Gray Treefrog, Hyla chrysoscelis. M.F. do Amaral, J. Frisbie, D.L. Goldstein, C. Krane. University of Dayton and Wright State University. F12 719.12 Salinity-Dependent Expression of ncc-like 2 in the Gill and Opercular Epithelium of Euryhaline Killifish. J. Doud, C. Popovski, E. Ritter, C. Tipsmark, J. Breves. Skidmore College and University of Arkansas. F13 719.13 FishResp: An R-Package for Filtering and Analyzing Raw Data in Aquatic Respirometry. S. Morozov, S.R. McCairns, J. Merilä. University of Helsinki, Finland and Institut National de la Recherche Agronomique (INRA), France. F14 719.14 Effect of Cortisol on Growth and Gene Expression of insulin-like growth-factor binding proteins (igfbps) In Atlantic Salmon Parr. R. Springer-Miller, D. Chenoweth, A. Paskavitz, A. Regish, S. McCormick, J. Breves. Skidmore College, USGS and Conte Anadromous Fish Research Center. F15 719.15 Role of the Protein Kinase G in the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Marine Invertebrate Aplysia. R. Chatterji, M. Wainwright, R. Mozzachiodi. Texas A&M University-Corpus Christi. F16 719.16 A Paradigm Shift: Benefits of Carbon Monoxide (CO) in Hypoxia-Adapted Species. M.S. Tift, P. Jordan, T. Lueker, P. Cabrales, T. Simonson, E. Heinrich, F. Villafuerte, J. Meir, D.E. Crocker, B. Moore, J. St. Leger, P.J. Ponganis. Scripps Institution of Oceanography, University of California, San Diego, Universidad Peruana Cayetano Heredia, NASA, Sonoma State University and SeaWorld. F17 719.17 Physiological Plasticity and Tolerance of Fundulid Killifish Species to Aquatic Hypoxia. R. Hoffman, B. Borowiec, G. Scott, C. Adams, F. Galvez. Louisiana State University and McMaster University, Canada. F18 719.18 Use of mTOR as a Potential Molecular Marker to Investigate the Development of Obesity in Non-Model Fish Species. R. Spainhour, J. Ball, Y. Kobayashi. Fort Hays State University. F19 719.19 Bicarbonate-Stimulated Soluble Adenylyl Cyclase Is an Acid-Base Sensor Present in the Cell Cytoplasm and Nucleus of Elasmobranch Fishes. J.N. Roa, M. Tresguerres. Scripps Institution of Oceanography.
720. NCAR YOUNG INVESTIGATORS AWARD POSTERS Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F20 720.1 Brief Exposure to Intermittent Hypoxia Prolongs QTc in Human Subjects, Which Is Abrogated with AT1a Receptor Blockade. N. Jouett, K. Bysani, D. Cooley, M. Cutler, P. Raven, M. Smith. University of North Texas Health Science Center, Texas College of Osteopathic Medicine and Intermountain Healthcare.
SUNDAY PHYSIOLOGY F21 720.2 Effect of Upper Body Position on Arterial Stiffness: Influence of Hydrostatic Pressure and Autonomic Function. E.C. Schroeder, T. Hilgenkamp, A.J. Rosenberg, D.W. White, T. Baynard, B. Fernhall. University of Illinois at Chicago, Erasmus MC University Medical Center Rotterdam, Netherlands and University of Houston-Victoria. F22 720.3 OVLT Neuron Responses to Hypertonic NaCl and Mannitol Differ: Implications for Neural Regulation of Blood Pressure by NaCl. B.J. Kinsman, K.N. Browning, S.D. Stocker. Penn State College of Medicine and University of Pittsburgh. F23 720.4 Black Adults Display Reduced Sympathetic Reactivity to Mental Stress Compared to Non-Hispanic White Adults. I.T. Fonkoue, C.E. Schwartz, B.M. Gervais, J.R. Carter. Michigan Technological University. F24 720.5 Reciprocal Inhibitory Integration and Respiratory Modulation of Arterial Chemoreceptor and Baroreceptor Inputs to Nucleus Tractus Solitarii. D.J. A. Moraes, M.P. da Silva, B.H. Machado, J.F. Paton. School of Medicne of Ribeirão Preto/USP, Brazil and University of Bristol, United Kingdom. F25 720.6 Renal Denervation Lowers Mean Arterial Pressure in Obese Female Schlager Mice but Adversely Affects Glucose Metabolism. N. Asirvatham-Jeyaraj, C.T. Banek, M.M. Gauthier, R. Han, M. Razzoli, A. Bartolomucci, A. Panoskaltsis-Mortari, J.W. Osborn. University of Minnesota. F26 720.7 Renal Pelvic Sensory Nerve Distribution Varies in Rat and Pig. J.L. Perry, N. Hoffman-Schepers, J. Syed, S. Siddiqui, J. Long, M. Knuepfer. Saint Louis University.
721. MICRORNAS IN HEALTH AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F27 721.1 Expression of Skeletal Muscle Mirna Are Unaltered During 14 Days of Bed Rest but Decrease Following 7 Days of Reloading in Middle-Aged Adults. E.J. ArentsonLantz, S. Lamon, C.S. Fry, K.L. English, D. PaddonJones. University of Texas Medical Branch and Deakin University, Australia. F28 721.2 miRNA-Mediated Regulation of Insulin Sensitivity in Skeletal Muscle Cells. J. Petrocelli, C. Beach, J.S. Marino. University of North Carolina, Charlotte. F29 721.3 Pathologic Role of microRNA-365 in the Heart. N. Valkov, T. Kim, M. Liu, J. Moeller, M. King, J. O-Uchi, Q. Chen, B. Choi, P. Zhang. Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Department of Orthopaedics and Rhode Island Hospital and Alpert Medical School of Brown University. F30 721.4 Spiny Mouse Is Protected from Ischemia Induced Cardiac Injury: Leading Role of microRNAs. Y. Qi, R. Goel, A.S. Mandloi, R. Vohra, G. Walter, Y.F. Joshua, T. Gu, M.J. Katovich, J.M. Aranda, M. Maden, M.K. Raizada, C.J. Pepine. University of Florida. F31 721.5 Myocardial Infarction-Induced miRNAEnriched Exosomes Contribute to Nrf2 Dysregulation in Chronic Heart Failure. C. Tian, L. Gao, I.H. Zucker. University of Nebraska Medical Center.
F32 721.6 Subconcussive Head Impact Results in a Unique Circulating Exosomal MicroRNA Signature. C.T. Caban, K. Jackson, C.L. Pinson, F.V. Dos Santos, J.J. Jeka, R.T. Tierney, M.B. Hudson. Temple University. F33 721.7 miR429: Potential Regulator of PAK2 in Inflammatory Monocytes. L.C. Stull, M.A. Amin, B.J. Rabquer. Albion College and University of Michigan. F34 721.8 MicroRNAs in Breast Cancer: Growing Understanding of Their Role in Metastasis and Invasion. H. AlHennawi, A. Bux, T. Khan, F. Yousuf, A. Rayes, S. Kazmi, L. Anwer, A. Nurhussen, M. Shareef, A. Yaqinuddin. Alfaisal University, Saudi Arabia, Mayo Clinic and Mercy St. Vincent Medical Center.
722. GENE EDITING, NON-CODING RNA, AND SYSTEMS BIOLOGY Poster (Sponsored by: APS Physiological Genomics Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F35 722.1 A CRISPR/Cas9 Toolbox for the Rapid Generation of Intersectional Dual Recombinase Mouse Lines for Anatomical, Molecular, and Functional Neural Circuit Mapping. J. Sun, R.S. Ray. Baylor College of Medicine. F36 722.2 Gene Editing Rat Resource Center (GERRC): Designer Rats for Heart, Lung and Blood Studies. R. Schilling, M. Gryzbowski, S. Pietrzak, A. Temple, A. Zappa, L. Lazcares, J. Niebuhr, S. Kalloway, J. Foeckler, A. Takizawa, A.M. Geurts, M.R. Dwinell. Medical College of Wisconsin. F37 722.3 Kidney-Specific Conditional Knockout of Klotho Gene Impairs Natriuresis and Causes Hypertension by Upregulating Epithelial Sodium Channel Alpha. Q. Ali, Y. Lin, S. Wang, K. Chen, J. Chen, Z. Sun. University of Oklahoma HSC. F38 722.4 The Relationship of miR-21-5p and PPARα in CKD-Related NAFLD and Dyslipidemia. V.L. Nasci, S. Miller, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. F39 722.5 Loss of miR-146b-5p Exacerbates Pathological Left-Ventricular Remodeling in a Rat Model of CKD. M. Paterson, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. F40 722.6 Selection and Characterization of Novel of RNA Aptamer Recognizing Homocysteine, Which Ameliorates Oxidative Stress in Mouse Brain Endothelial (bEND3) Cells. J. Bala, J. Behera, K. Kelly, N. Tyagi. Univerisity of Louisville. F41 722.7 Dynamic Bayesian Graphical Modeling to Predict Regulatory Networks in Hypertensive Rats. A. Dayton, K. Ahn, P. Liu, P. Laud, F. Stingo, M. Vannucci, J.D. Bukowy, M. Liang, A.W. Cowley Jr. Medical College of Wisconsin, MD Anderson Cancer Center and Rice University. F42 722.8 Modeling of Calcium-Induced Swelling in Spatially Divergent Populations of Cardiac Mitochondria. X.R. Chapa, V. Makarov, S. Javadov. UPR Medical Science Campus and UPR Rio Piedras Campus. F43 722.9 Discovering Interactions and Connections with Bioinformatics Tools at RGD. M. Shimoyama, S. Laulederkind, J. De Pons, M. Tutaj, J. Thota, O. Ghiasvand, V. Petri, J.R. Smith, G.T. Hayman, S. Wang, M. Dwinell. Marquette University and Medical College of Wisconsin and Medical College of Wisconsin.
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PHYSIOLOGY SUNDAY F44 722.10 Simulating Selected Human Hormonal Pathways During a 24-Hour Period and Its Implications for Aging Research. S.A. Garan, G. Efe, K. Cheung, M.A. Khurramb, R. White, J.A. Yukich, G.A. Brooks. UC Berkeley. F45 722.11 A Thermodynamically Constrained Mechanistic Mathematical Model for the Kinetics of NADPH Oxidase Assembly, Activation and ROS Production. N. Tomar, V.R. Pannala, C. Yang, A.W. Cowley, R.K. Dash. Medical College of Wisconsin. F46 722.12 Genelab: Multi-Omics Investigation of Rodent Research-1 Biobanked Tissues. K. Chakravarty, S. Lai, V. Boyko, D. Berrios, H. Fogle, S. Dueck, L. Timucin, J. Galazka, S. Reinsch, O. Stotzky, M. Skidmore. NASA/ Logyx LLC, NASA/kbrWyle, NASA/Bionetics, NASA/University Affiliated Research Center/University of California Santa Cruz and NASA Ames Research Center. F47 722.13 Development of Tools for RNA Interference (RNAi) of the Engrailed Gene in Daphnia magna. D. Singer, M. Beckman. Augsburg College. F48 722.14 Comprehensive Coverage of Rat Models for Human Diseases at the Rat Genome Database. S. Wang, S.J. Laulederkind, J.R. Smith, G.T. Hayman, V. Petri, M. Dwinell, M. Shimoyama. Medical College of Wisconsin.
723. REPRODUCTION, SEX HORMONES, AND GESTATIONAL BIOLOGY
F54 723.6 Effects of Culture Time, Fetal Bovine Serum, Progesterone, Testosterone and Estradiol on Alkaline Phosphatase Activity, Extracellular Matrix Mineralization and Osteoblast Viability. J.E. Lemos, L.F. Brancaglião, A.L. Bonfá, N.F. Rocha, V.M. Gonçalves, L.H. Montrezor. University of Araraquara—UNIARA, Brazil. F55 723.7 Reversible Azoospermia After Long Term Sustained Delivery of DHT. H.A. Benghuzzi. University of Mississippi Medical Center. F56 723.8 Prenatal Food Restriction Causes Adaptive Changes in the Metabolic Regulation of Reproductive Physiology. E.M. Rhinehart. Susquehanna University. F57 723.9 Effect of Perinatal Blockade of Androgen Receptors on Estrogen Receptor Levels in Specific Brain Regions and Spatial Working Memory in Male Rats. R. Hershkowitz, B. Shah, P.A. Nehrt, A. Sanchez, T. Secor, B. Starr, S. Toennies, G. Taylor, C. Gopalan. Southern Illinois University Edwardsville, St. Louis College of Pharmacy and University of Missouri St. Louis. F58 723.10 Letrozole and/or Fructose Induced-Polycystic Ovarian Syndrome in Animal Model. C.O. Akintayo, J.D. Anjola. Afe Babalola University, Nigeria.
724. AUTONOMIC AND RESPIRATORY INTERACTIONS Poster
Poster (Sponsored by: APS Endocrinology and Metabolism Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F49 723.1 Brain Inflammation and Oxidative Stress in the Developmental Programming of Metabolic Syndrome in Adult Offspring to Maternal Nutrition Insult. J.Y. Chan, Y. Chao. Kaohsiung Chang Gung Memorial Hospital, Taiwan. F50 723.2 Fetal Brain Sparing in a Mouse Model of Chronic Maternal Hypoxia. L.S. Cahill, Y. Zhou, J. Hoggarth, M. Seed, C.K. Macgowan, J.G. Sled. Mouse Imaging Centre, The Hospital for Sick Children, Canada, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, Canada, Department of Medical Biophysics, University of Toronto, Canada, Physiology & Experimental Medicine and The Hospital for Sick Children, Canada. F51 723.3 Duality of Early Life Maternal Separation Effects on Offspring Initial Development and Maternal Neuronal Activation. D.R. Fóscolo, F.S. Machado, C.C. Coimbra. Universidade Federal de Minas Gerais (UFMG), Brazil. F52 723.4 Preterm Birth Is Associated with a Decrease in Cervicovaginal L. iners During Second Trimester in Mexican Women. P. Rodriguez-Martin, B. PalaciosGonzalez, F. Vadillo-Ortega. Instituto Nacional de Medicina Genomica, Mexico. F53 723.5 Feed Restriction and IGF-1 Affect the Oocyte Maturation in Matrinxa˜ Brycon amazonicus. L.H. Montrezor, E.C. Urbinati. University of Araraquara—UNIARA, Brazil and Univ. Estadual Paulista—UNESP, Brazil.
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(Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F59 724.1 Firing Properties of Pre-Inspiratory Neurons Are Altered in Female Rats Exposed to Chronic Intermittent Hypoxia. G.M. Souza, M.R. Amorim, D.J. Moraes, B.H. Machado. University of Sao Paulo, Brazil. F60 724.2 Effects of Deep Controlled Breathing on Heart Rate Variability in Young Adults. D. Grigorieva, D. Dimitriev, E. Saperova. Chuvash State Pedagogical University, Russian Federation. F61 724.3 Ventral Medullary Inspiratory Neurons Recordings in Rats Submitted to Sino-Aortic Denervation. M.R. Amorim, G.M. Souza, L.G. Bonagamba, B.H. Machado. School of Medicine of Ribeirão Preto/USP, Brazil. F62 724.4 Effects of Lipopolysaccharide Injection on in Vivo Breathing Pattern in Developing Rats. R.L. Johnson, S. Murray, C.G. Wilson. Loma Linda University. F63 724.5 Six Weeks Inspiratory Muscle Strength Training Lowers Blood Pressure but Does Not Affect Baroreflex Sensitivity or Cardiac Output in Active Young Adults. C.M. DeLucia, R.M. De Asis, E.F. Bailey. The University of Arizona. F64 724.6 A Cellular Mechanism of Leptin Mediated Responses in Mouse NTS Neurons. J. Do, A. Kowal, L. Floreani, D.R. McCrimmon, M. Martina. Northwestern University and International School for Advanced Studies, Italy. F65 724.7 The Vagus Nerve in Development of Lung Tumor. J. Liu, N. Song, J. Guardiola, J. Yu. University of Louisville and Robley Rex VA Med Center. F66 724.8 Improvement in Lower Urinary Tract Function Following a Single Bout of Acute Intermittent Hypoxia in Rats with Chronic Spinal Cord Injury. W.F. Collins, N.P. Phagu, M. Catege, I.C. Solomon. Stony Brook University.
SUNDAY PHYSIOLOGY
725. AIRWAY EPITHELIUM IN HEALTH AND DISEASE Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F67 725.1 Multipotent Myoepithelial Progenitor Cells Are Born Early During Airway Submucosal Gland Development. P. Anderson, T. Lynch, J. Engelhardt. University of Iowa. F68 725.2 Effects of Perinatal Nicotine Exposure on Cholinergic Signaling in the Airway Epithelium. N. Borrero, R. Fregosi, S. Boitano. University of Arizona. F69 725.3 Reducing Allergic Asthma Inflammation and Airway Hyperresponsiveness via a Novel Protease-Activated Receptor-2 Antagonist. C.M. Rivas, M.K. Lovett, T. Neenan, M. Yee, K.A. DeFea, M. Daines, J. Vagner, S.A. Boitano. University of Arizona, University of California at Riverside. F70 725.4 Sodium-Coupled Neutral Amino Acid Transporter SNAT2 Counteracts Edema Formation and Reduces Autophagy and Er Stress in Acute Lung Injury. S. Weidenfeld, C.J. Chupin, S. Rozowsky, W.M. Kuebler. Keenan Research Centre for Biomedical Science, St. Michael´s Hospital, Canada, Charité-Berlin, Germany and University of Toronto, Canada. F71 725.5 Evidence for ACE-2 Ubiquitination and Proteasomal Processing in Lung Epithelium. A. Abdul-Hafez, J. Markey, B. Uhal. Michigan State University. F72 725.6 Utility of Abbreviated Exposure Time in Mice— Contribution to Understanding Pathogenesis of Cigarette Smoke Induced Lung Disease. M.R. Wolfson, S.T. Baker, Y. Tian, K. Bahmed, B. Kosmider, M.M. Marcinkiewicz, J. Wu. Lewis Katz School of Medicine at Temple University.
726. AIRWAY RESPONSIVENESS AND SMOOTH MUSCLE CELL BIOLOGY
F77 726.5 Novel Inflammatory Mechanisms in the Regulation of Airway Hyperresponsiveness: Regulation of Airway Smooth Muscle Kv7 Channel Expression by Rest. L.I. Brueggemann, C. Zhang, P.P. Kakad, L.L. Cribbs, K.L. Byron. Edward Hines Jr. VA Hospital and Loyola University Chicago. F78 726.6 Regulation of Endogenous Kv7 Potassium Channels by Histamine in Primary Cultured Human Airway Smooth Muscle Cells. J.M. Haick, L.I. Brueggemann, J.L. Schwartz, K.L. Byron. Loyola University Chicago and Edward Hines Jr. VA Hospital. F79 726.7 Reflex Bronchoconstriction Evoked by Inhaled Nicotine Aerosol in Guinea Pigs: Role of the Nicotinic Acetylcholine Receptor. R. Lin, M. Khosravi, F. Xu, L. Lee. University of Kentucky and Lovelace Respiratory Research Institute. F80 726.8 Resveratrol Protects Against HyperoxiaInduced Airway Hyperreactivity in Neonatal Rats. R.B. Sopi, S. Reçica, A. Lajçi, I. Kryeziu, Q. Thaçi, I.A. Dreshaj, M. Basholli. University of Prishtina, Faculty of Medicine, Kosovo, University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo, Case Western Reserve University and School of Medicine. F81 726.9 Quercetin Reverses the Enhanced Contractile Responses of Tracheal Smooth Muscle of Neonatal Rats Exposed to Hyperoxia. I. Kryeziu, Q. Thaçi, S. Reçica, F. Kurshumliu, D. Vela, M. Mladenov, M. Basholli, R.B. Sopi. University of Prishtina, Faculty of Medicine, Kosovo, University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo and Ss.Cyril and Methodius University—Faculty of Mathematics and Natural Sciences, Former Yugoslav Republic of Macedonia. F82 726.10 Role of PGE2-EP1/EP3 Receptor Signaling on Hyperoxia-Induced Airway Hyperreactivity in Neonatal Rats. Q. Thaçi, A. Cenaj, R.B. Sopi. University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo, University of Prishtina and Faculty of Medicine, Kosovo.
727. CONTROL OF BREATHING: DEVELOPMENT
Poster
Poster
(Sponsored by: APS Respiration Section)
(Sponsored by: APS Respiration Section)
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Sun. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:45 pm–3:00 pm
Presentation time: 12:45 pm–3:00 pm
F73 726.1 Sex Differences and Role of Sex Hormones in the Expression of Inflammatory Mediators and Lung Function in Response to Ozone. N. Fuentes, N. Cabello, M. Nicoleau, P. Silveyra. Penn State College of Medicine. F74 726.2 Modulation of the Lung Inflammatory Response to Ozone by the Estrous Cycle. P. Silveyra, N. Cabello, S. DiAngelo. Penn State College of Medicine. F75 726.3 Activation of Bitter Taste Receptors Has Distinct Modulatory Effects on Different Lung Afferent Signaling in Rats. Q. Gu, C. Gilbert, H. McLaurin. Mercer University School of Medicine. F76 726.4 TNFα Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells. J.Q. Yap, P. Delmotte, G.C. Sieck. Johns Hopkins University and Mayo Clinic.
F83 727.1 Impact of Gestational Chronic Intermittent Hypoxia and Hypertension on the Serotonergic System and Autoresuscitation in the Developmental Rat. D. Harvey, A. Carrillo Leal, A. Li. Dartmouth College and Geisel School of Medicine at Dartmouth. F84 727.2 Intermittent Hypoxia During Gestation Disrupts Respiratory Rhythm and Neuroplasticity in Newborn Rat Brainstem-Spinal Cord Preparations in Vitro. S.M. Johnson, J. Watters, K. Randhawa. University of Wisconsin-Madison. F85 727.3 Abnormalities in Excitability of Nucleus Tractus Solitarius (nTS) Neurons Following Neonatal Hypoxia Exposure: Implications for Sudden Infant Death Syndrome. C. Mayer, P. MacFarlane. Case Western Reserve University. F86 727.4 Divergent Effects of Myo-Inositol Supplementation on Respiratory Control During Postnatal Development. P. MacFarlane, J. Di Fiore, C. Mayer. Case Western Reserve University and Rainbow Babies & Children’s Hospital.
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PHYSIOLOGY SUNDAY F87 727.5 A Low Cost, Simplified, and Scaleable Pneumotachograph and Face Mask for Neonatal Mouse Respiratory Measurements. J.J. Sun, R. Nanu, R.S. Ray. Baylor College of Medicine and Brandeis University. F88 727.6 Functional Characterization of Developmental Whole Rhombomere Brainstem Populations in Adult Respiratory Physiology. J.J. Sun, R.S. Ray. Baylor College of Medicine. F89 727.7 Sex-Specific Effects of Nuclear and Membrane Progesterone Receptors on Breathing Stability in Newborn Rats. R. Boukari, A. Bairam, V. Joseph. CRIUCPQ— Université Laval, Canada. F90 727.8 Arousal Defects and Apnea in Rat Pups Deficient in Central 5-HT: Interactions with Sleep State. J.O. Young, M. Hodges, K. Cummings. University of Missouri and Medical College of Wisconsin. F91 727.9 Effects of Perinatal Nicotine or Inflammation Exposure on Ventilation in the Developing Rat Model. P.A. Williams, C. Wilson. Loma Linda University and School of Medicine.
728. CONTROL OF BREATHING: INTEGRATED RESPONSES Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F92 728.1 Hypercapnic and Hypoxic Ventilatory Response in Streptozotocin-Model of Alzheimer’s Disease During Wakefulness. M.C. Vicente, K.C. Bícego, D.C. Carrettiero, L.H. Gargaglioni. São Paulo State University, Brazil and Federal University of ABC, Brazil. F93 728.2 The Metaboreflex and the Peripheral Chemoreflex Interact for the Regulation of Ventilation in Patients with Chronic Heart Failure. A.C. Machado, L.C. Vianna, E.A. Gomes, J.A. Teixeira, M.L. Ribeiro, H.V. Junior, A.C. Nobrega, B.M. Silva. Fluminense Federal University, Brazil, Federal University of Latin American Integration, Brazil, University of Brasília, Brazil, Federal Fluminense University, Brazil and Federal University of São Paulo, Brazil. F94 728.3 Ventilatory Response Arising from the Interaction Between the Peripheral Chemoreflex and the Muscle Mechanoreflex in Healthy Humans. T.M. Silva, L.C. Aranda, M.P. Ribeiro, W.M. Medeiros, L. Viana, L.E. Nery, B.M. Silva. Federal University of São Paulo (UNIFESP), Brazil, University of Brasilia, Brazil and Federal University of São Paulo, Brazil. F95 728.4 Changes in Physiological Variables During Slow- and Rapid-Onset Airway Obstruction in Swine. M.B. Blackburn, C. Nawn. United States Army Institute of Surgical Research, University of Texas at San Antonio and Oak Ridge Institute for Science and Education. F96 728.5 Effects of Cervical Spinal Cord Injury on Cough. T. Pitts, A. Huff, C. Greene, K.A. Cheffer, W.A. O’Steen, D.R. Howland. University of Louisville and Robley Rex VA Medical Center. F97 728.6 Cervical C2 Hemisection Acutely Induces Swallow Hyperreflexia. A. Huff, C. Greene, K.A. Cheffer, W.A. O’Steen, D.R. Howland, T. Pitts. University of Louisville and Robley Rex VA Medical Center.
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F98 728.7 Activation of Esophageal Mechanoreceptors Alters the Pharyngeal Phase of Swallow. A. Brown, S.N. King, I. Poliacek, T. Pitts. University of Louisville and Comenius University in Bratislava, Slovakia. F99 728.8 Gasotransmitters in Sleep Apnea. X. ‘Zhang, Y. Peng, C. Irina, Gridina, J. Nanduri, G. Kumar, S. Snyder, P. Nanduri. The University of Chicago and Johns Hopkins University. F100 728.9 Ovalbumin-Induced Airway Inflammation Enhances Hypoxic Ventilatory Response in Rats. O. Broytman, J. Brinkman, D. Pegelow, B. Morgan, M. Teodorescu. Univ of Wisconsin. F101 728.10 The Effects of Five Clinically Relevant Narcotic Drugs on the Generation of Spontaneous Augmented (Sigh) Breaths. C.T. Kortes, K. Grzesek, H.J. Bell. Central Michigan University. F102 728.11 A Study of Gender Influence on the Pattern of Cardiorespiratory Response to Transient and Unrelenting Acute Severe Hypoxemia in Adult Rats. N.J. Van Maele, C.J. Hosner, H.J. Bell. Central Michigan University. F103 728.12 Optogenetic Activation of Leptin-Receptor Expressing Neurons in the Region of the Dorsomedial Hypothalamus Increases Respiratory Motor Output in Mice. Z. Chang, A.S. Kowal, G. Sekerkova, K.E. McKenna, M. Martina, D.R. McCrimmon. Northwestern University. F104 728.13 Infrared Laser Light Elicits Cardiorespiratory Responses When Applied to the Nucleus Tractus Solitarius in the in Situ Rat Brainstem Preparation. G. Kola, T.E. Dick, M. Dutschmann, H. Chiel, M. Jenkins, S.J. Lewis. Case Western Reserve University and Howard Florey Institute of Neuroscience and Mental Health, Australia. F105 728.14 Basal Ventilatory Activity in Conscious Freely Moving Spontaneously Breathing 6-OHDA SNLesioned Parkinson’s Disease Rat Model. R.M. Wadolowski, S.B. Wadolowski, W.F. Collins III, I.C. Solomon. Stony Brook University. F106 728.15 Respiratory Control in a Rat Model of Alzheimer’s Disease (TgF344-AD). K.H. Murphy, D.P. Burns, K. Barry-Murphy, M.G. Rae, K.D. O’Halloran, E.F. Lucking. University College Cork, Ireland.
729. RHYTHM GENERATION Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F107 729.1 In Vivo Studies of Brainstem Neurons with Respiratory Rhythm Activity in a Rat Model of Rett Syndrome. Y. Wu, N. Cui, H. Xing, W. Zhong, C.M. Johnson, C. Jiang. Georgia State University. F108 729.2 The Norepinephrine-Dependent “Postinspiratory Complex” Is Not an Autonomous Generator of the Postinspiratory Rhythm. C. Poon, G. Song. Massachusetts Institute of Technology. F109 729.3 Eupnea, Tachypnea, and Autoresuscitation in a Closed-Loop Respiratory Control Model. C.O. Diekman, C.G. Wilson, P.J. Thomas. New Jersey Institute of Technology, Loma Linda University and Case Western Reserve University.
SUNDAY PHYSIOLOGY F110 729.4 Phasic Inhibition Differentially Modulates Synaptic Dynamics Among Excitatory PreBötzinger Complex Populations to Promote Rapid Breathing in Vivo. N.A. Baertsch, T. Dashevskiy, H.C. Baertsch, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F111 729.5 The Differential Effect of Systemic Inflammation and Chronic Intermittent Hypoxia on the Respiratory Networks Generating Inspiration and Postinspiration. I.M. Agosto, S. Ramirez, A.J. Garcia III, J. Ramirez. Seattle Children’s Research Institute and University of Chicago. F112 729.6 Modulation of KCNQ Channels Is a Potential Mechanism for Controlling Inspiratory Burst Duration. A.L. Revill, A. Katzell, G.D. Funk. University of Alberta, Canada. F113 729.7 Triple Oscillator Hypothesis: Three Excitatory Rhythm Generating Networks Control the Three Phases of Breathing. T.M. Anderson, A.J. Garcia III, N.A. Baertsch, J. Pollak, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F114 729.8 Transitioning to Normal Breathing in Pre-Term and Term Pups During the First Hours of Birth. S.C. Ramirez, I.M. Agosto-Marlin, C.V. Smith, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F115 729.9 Isolated Bullfrog Rostral Brainstems Exhibit a DAMGO-Insensitive Lung-Like Episodic Rhythm in the Presence of Bicuculline. M. Reed, K. Iceman, M. Harris, B. Taylor. University of Alaska, Valparaiso University and California State University Long Beach.
730. LUNG BIOMECHANICS, SURFACTANT AND GAS EXCHANGE Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F116 730.1 Cigarette Smoke Induced Alterations in Bone Microarchitecture: Regional Differences in a Mouse Model. G. Calendo, D.T. Stapor, S.T. Baker, M. Amin, M.F. Barbe, M.R. Wolfson. Lewis Katz School of Medicine at Temple University. F117 730.2 Postural and Perfusion Related Effects on Lobar Deformation Heterogeneity Following Pneumonectomy Assessed by High Resolution Computed Tomography (HRCT). D.M. Dane, N.J. Tustison, C. Yilmaz, A.S. Estrera, J. Gee, C.C. Hsia. University of Texas Southwestern Medical Center, University of Virginia and University of Pennsylvania.
F118 730.3 Effects of Inhaled Erythropoietin on Canine Post-Pneumonectomy Compensatory Lung Growth. D.M. Dane, C. Yilmaz, D. Gyawali, P. Ravikumar, A.S. Estrera, J. Menon, K. Nguyen, N.J. Tustison, J.C. Gee, C.C. Hsia. University of Texas Southwestern Medical Center, University of Texas at Arlington, University of Virginia and University of Pennsylvania. F119 730.4 The Effect of Equilibriative Nucleoside Transporter 1 on Pseudomonas Aeruginosa-Induced Acute Lung Injury. E.D. Chambers, A. Healy, A. Morrison, S. Rounds, Q. Lu. Alpert Medical School of Brown University and Providence VA Medical Center.
731. REGENERATIVE MEDICINE Poster (Sponsored by: Biomedical Engineering Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F120 731.1 Development of a Poly(Lactic Acid) and Fibrin Device for Use in Bone Regenerative Medicine. R.A. Carvalho, V.V. Rocha Júnior, E.J. Silva, E. Trovatti, M.R. Iemma, A.C. Amaral. University of Araraquara, Brazil and University of São Paulo, Brazil. F121 731.2 Isolation and Expansion of “Youthful” Bone Marrow Mesenchymal Stem Cells from Elderly Individuals. T.J. Block, M. Marinkovic, O. Tran, D.D. Dean, X. Chen. StemBioSys and University of Texas Health Science Center at San Antonio. F122 731.3 Bioactive Fibrin Scaffolds for Use in Regenerative Medicine. S.F. Braga, R. Aquino, A. Carvalho, E. Trovatti, M. Iemma, A.C. Amaral. University of Araraquara, Brazil and University of São Paulo, Brazil. F123 731.4 The Growth and Differentiation Capacity of Porcine Renal Papilla Progenitor Cells Decline with Passaging. D.M. Burmeister, M.K. McIntyre, B.I. Gomez, R. Mongomery, M.A. Dubick. United States Army Institute of Surgical Research. F124 731.5 Angiotensin-(1-7) Treatment Aids in the Recovery of Skeletal Muscle Function After Acute Injury in Rats. T. Criswell, Y. Zhou, B. Yoseph, T. Criswell. Wake Forest Institute for Regenerative Medicine.
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MONDAY, APRIL 24 Anatomy 732. ANATOMY EDUCATION: FACTORS AFFECTING STUDENT PERFORMANCE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E1 732.1 Interprofessional Education in Anatomy: Using Q Methodology to Determine Student Perceptions. C. Mackinnon, N. Akhtar-Danesh, A. Palombella, B. Wainman. McMaster University, Canada. E2 732.2 First Year Medical Students’ Perceptions of Professionalism. E.M. Encisco, A.C. Edmondson, C.A. Nichols. Medical College of Georgia at Augusta University. E3 732.3 Comparison of Academic Performance Within the First Year of Medical School with Performance on a National Board of Medical Examiners (NBME) Comprehensive Exam. W. Yang, C.A. Nichols, A.C. Edmondson. Medical College of Georgia at Augusta University. E4 732.4 Introductory Anatomy Laboratory Teaching, Correlations Between Contact Hours and Student Success. A.J. Oh, L. Georger, E.M. Rokitka, J. Holz, N.R. Olivieri, F. Stephen, M.P. Olivieri. D’Youville College. E5 732.5 The Effect of Retrieval Practice After Sleep on Student Learning. C. Perry, R. Easteal. Queen’s University, Canada. E6 732.6 Student Perception of the Value of Previous Anatomy Coursework on Medical Gross Anatomy. E. Robertson, K. Thompson, A. Notebaert. University of Mississippi Medical Center and Millsaps College. E7 732.7 Characteristics of a Good Basic Science Teacher as Perceived by Medical Students. I. Hajj Hussein, T. Wunderlich, S. Loftus, R. Wedemeyer. OUWB School of Medicine. E8 732.8 Previous Learning Experiences in the Anatomical Sciences. M. Taylor. Indiana University. E9 732.9 Influence of Learning Paradigms on the Retention of Anatomical Knowledge in Medical Students. M. Ahmed, S. Dykowski, T. Tooley, T. Helland, M. Barremkala. Oakland University William Beaumont School of Medicine. E10 732.10 Student Performance in and Perception of Gross Anatomy in Varied Curricular Material Organization in Multiple Cohorts. K.L. Thompson. Mercer University SOM. E11 732.11 Superficial Versus Deep Learning in a Professional Veterinary Anatomy Curriculum. M.A. McNulty, H.A. Richbourg. Louisiana State University School of Veterinary Medicine and Indiana University School of Medicine. E12 732.12 Correlation of Brief Cope and Academic Performance in First Year PA and Dental Students During Human Structure Course. A.S. Thiessen, N. Halliday. University of Oklahoma and University of Oklahoma Health Sciences Center.
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E13 732.13 Student Perceived Difficulties in Learning Organ Systems in an Undergraduate Human Anatomy Course. J. Shaffer, R. Lieu, A. Gutierrez. University of California at Irvine. E14 732.14 Is Anatomy Important for Speech Language Pathology (SLP) Undergraduate Students? M.D. Barros, V.A. Silva, B.M. Liquidato. Santa Casa de São Paulo School of Medical Sciences, Brazil. E15 732.15 Observational Exercise in the Anatomy Lab and Narrative Reflection Contribute to Professional Identity Formation in Medical Students. G. Sorrentino, W. Rennie, A. Fornari, K. Metzger. Hofstra Northwell School of Medicine and Seton Hall-Hackensack Meridian School of Medicine. E16 732.16 Sink, Swim, or Grab a Lifesaver: First Year Medical Student Perception of Academic Performance and Tutoring in an Anatomy Course. P. Stadem, A.D. Ginsburg, F. Hafferty, N. Lachman, W. Pawlina, N. Langley. Mayo Clinic College of Medicine and Science. E17 732.17 internationalization of Medical Education—A Pilot Study Using a Shared Digital Dissector and Early PeerTo-Peer Student Interaction in American and German Clinical Gross Anatomy Courses. A. Wu, C. Goelkel, C. Chiuzan, J. Duong, H. Kielstein, P. Bernd. Columbia University and Martin-Luther-Universitaet, Germany.
733. ANATOMY EDUCATION: LAB TEACHING STRATEGIES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E18 733.1 Perceptions of Dissection Experience in a Professional Veterinary Curriculum. M.A. McNulty, H.A. Richbourg, M.D. Lazarus. Louisiana State University School of Veterinary Medicine, Indiana University School of Medicine and Monash University, Australia. E19 733.2 Utilizing Medical Students’ Attitudes Toward Whole Body Donation in Developing a Whole Body Donation Program. S. Dykowski, M. Ahmed, T. Tooley, T. Helland, M. Barremkala. Oakland University William Beaumont School of Medicine. E20 733.3 Perception of Body Donation Among African Americans. A. Werede, B. Thompson. Oakland University William Beaumont School of Medicine. E21 733.4 Use and Perceptions of Plastination Among Anatomy Medical Educators in the United States. R. Klaus, D. Royer, J. Corral, M.E. Stabio. University of Colorado Anschutz Medical Campus. E22 733.5 Interactions and Perceptions About the Learning Process of Second Year Medical Students When Using Non-Conventional Anatomical Specimens at a Heart and Coronary Anatomy Practical Class. R.J. Rueda-Esteban, C. Hernández. Universidad de los Andes, Colombia.
MONDAY ANATOMY E23 733.6 Everything Old Is New Again: An Alternate Approach to Human Hip Dissection Inspired by a Classic 19th Century Experiment. A. D’Abarno, M. Singleton. Chicago College of Osteopathic Medicine and Midwestern University. E24 733.7 Dissection Opportunity Affects Student Performance on Gross Anatomy Practical and Lecture Examination Questions. A. Marshall, A.R. Thompson. University of Cincinnati College of Medicine. E25 733.8 The Minute Clinic: Increasing Student Engagement in an Undergraduate Systems-Based Anatomy Course. C.A. Hill, K. Aldridge, C.M. Holliday, K.M. Middleton, C.V. Ward, S.A. Maiolino, M.E. Jorgensen. University of Missouri-Columbia and Rocky Vista University College of Osteopathic Medicine. E26 733.9 The Anatomy Laboratory as a Fulcrum of Basic and Clinical-Science Integration. F. Nausheen, G. Al-Eyd, R. Ettarh, S. Hassan, M. Yakub, R. Suskind, A. Tenore. California University of Science and Medicine and School of Medicine. E27 733.10 Pilot Project: Delivering Ultra-Low Cost Digitally Guided Dissection. T. Frasch, M.L. Korndorffer; MD; FACS. Tulane University. E28 733.11 Navigating Your First Cut: A Hands-Off Animated Guide to the First Year Anatomy Lab. M. Garabedian, Z. Rothman, M. Fejtek, L. Vo, C. Krebs. University of British Columbia, Canada. E29 733.12 The Use of Radiological Imaging to Enhance Gross Anatomical Learning: Thoughts and Practices. S.D. Inglis, A.M. Delbalso, R.P. Dannenhoffer. University at Buffalo.
734. ANATOMY EDUCATION: OUTREACH Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E30 734.1 Contributing to the Future of Diversity in Medicine: A Powerful Outreach Program at the SUNY Downstate College of Medicine. A. Diaz, T. Jones, A.S. Pagano, S. Márquez. SUNY Downstate Medical Center and NYU School of Medicine. E31 734.2 Building Bridges Between Brazil and the US: Anatomical Sciences and Medical Education. D.F. Curcio, J.T. Laitman. Icahn School of Medicine at Mount Sinai and Santa Casa School of Medical Sciences—Sao Paulo, Brazil. E32 734.3 Neuroscience Outreach Education: Establishing Partnerships Between Graduate and Secondary School Programs. B. Puder. Samuel Merritt University. E33 734.4 Anatomical Connections: Linking High Schools to the UVM College of Medicine with Anatomy. S.A. McCarthy, S.P. Flynn, L. Merrill. University of Vermont. E34 734.5 Physiology Understanding Week (PhUn Week), First Time in Kingsville, Texas: The Immune System. R.A. Johnson. Texas A&M University—Kingsville. E35 734.6 PhUn Overview of the Cardiovascular System. R. Williams, M.E. Hernandez-Velez. Texas A&M Kingsville.
E36 734.7 Medical Education Across Borders—Are You GAAAME? J.M. Ziermann, D.F. Curcio. Howard University College of Medicine, Icahn School of Medicine at Mount Sinai— New York and Santa Casa School of Medical Sciences—Sao Paulo, Brazil. E37 734.8 Inside Dinosaurs: A Broader Impacts Program for Research, Teaching and Public Education Through Dinosaur Biology, Physics and Evolution. C.M. Holliday, C.A. Hill, J.L. Davis, L.M. Witmer, K.M. Middleton. University of Missouri, University of Southern Indiana and Ohio University. E38 734.9 Medical School Anatomy/Pathology Workshops for High School Students Enhance Learning, Model Professionalism, and Provide Inspiration for Careers in Medicine. G. Zhang, B.A. Fenderson, J.J. Veloski, M. Livesey, T. Wojdon-Smith. Thomas Jefferson University and Eastern Regional High School. E39 734.10 An Innovative Pedagogical Project to Study the Genital System and Learn About Sexually Transmitted Diseases (STDs) in Brazilian Public High School. T.S. Masuko, L.d. Fragassi, D.T. Conceição, L.D. Souza Santos, T. Andrade Magalhães, M.M. Maron e Silva, L.M. Moraes. UFBA—Federal University of Bahia, Brazil.
735. ANATOMY EDUCATION: CLINICAL SKILLS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E40 735.1 Anterior Components Separation (ACS) by Endoscopic Pathway: Alternative Pathway to Approach the Abdominal Wall. M.D. Barros, S. Roll, R.T. Nishio, R.A. Silva, D.P. Ayres Neto, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E41 735.2 Transoral Thyroidectomy: Anatomical Aspects of an Esthetic Access. M.D. Barros, A.J. Gonçalves, R.T. Nishio, N.K. Kavabata, D.P. Ayres Neto, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E42 735.3 Improving the Use of Pelvic Binding Devices During Pre-Hospital Care Through Application Modules on Advanced Dissection Specimens During Advanced Care Paramedic Labs. A.J. Stubbs, G. Sullivan, L.C. Jadeski. University of Guelph, Canada. E43 735.4 Teaching Model for Reconstruction of the Abdominal Wall via the Separation of Anterior and Posterior Components Technique. M.D. Barros, S. Roll, R.A. Silva, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E44 735.5 Effect of Simulation-Based Cerebral Angiography Training on Navigational Error in Novices. O. Zaika. Western University, Canada. E45 735.6 Integrating Clinical Medicine with the Basic Sciences: Musculoskeletal System Cadaver-Based Learning Module for Medical Students. M. Doroudi, A. Majdzadeh, A. Wong, H. Nouraei. UBC, Canada.
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736. ANATOMY EDUCATION: 3D MODELS Poster
Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Education
Education
Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm
Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm
E46 736.1 To Model or Not to Model Embryonic Heart Development, That Is the Educational Question. B. Blezinski, A. Richardson, L.M. Lee. University of Colorado Denver Anschutz Medical Campus and University of Colorado School of Medicine. E47 736.2 Aortic Automatic Segmentation and 3D Printing for Educational Purpose—A Preliminary Approach. J.D. Coronel, J. Palacio Varona, R.J. Rueda Esteban, P.A. Abelaéz Escalante. Universidad de los Andes, Colombia. E48 736.3 From 3D Brains to 3D PDFs: Creating Virtual 3D Models of Human Brains for Neuroanatomy Classes Through Photogrammetric 3D Scanning. R. Sikes, C. Bernardo, E. Yavetz, J. Chan. Northeastern University. E49 736.4 3D Methods for Medical Education and Clinical Practice. M. Buynak, L.K. Song, D. Dufeau. Marian University College of Osteopathic Medicine. E50 736.5 An Innovative 3 Dimensional Model of Middle Ear. S. Dixit, A. Dixit, S. Ghatak. All India Institute of Medical Sciences and Jodhpur, India. E51 736.6 The Promise of Mixed Reality in Anatomy Education. M. Romaniuk, J. Lamb, J. Mitchell, I. Bayer, B. Wainman. McMaster University, Canada. E52 736.7 Segmenting the Data Stream: Harnessing Contrast-Enhanced Imaging from Widely Available, Anonymized Patient Data to Generate 3-D Training Tools for Clinical Gross Anatomy. J.T. Todd, P.M. Gignac. Oklahoma State University Center for Health Sciences. E53 736.8 Visualization of Cardiac Anatomy: New Approaches for Medical Education. R.M. Whitman, D. Dufeau. Marian University College of Osteopathic Medicine. E54 736.9 Imaging and 3d Reconstruction of Anatomical Specimens as an Alternative to Traditional Learning Models. S.D. Inglis, J.E. Tomaszewski, R.P. Dannenhoffer. University at Buffalo. E55 736.10 3D Printed Models to Visualize Fascial and Peritoneal Layers of the Abdomen in Medical Gross Anatomy. M.E. Orczykowski, A. Zumwalt. Boston University School of Medicine. E56 736.11 Assessing the Use of Paper Musculoskeletal Models in Anatomy and Physiology Classes for Undergraduate Students. S.J. Rehorek, P.G. Falso. Slippery Rock University. E57 736.12 Creation and Evaluation of 3D Sectioned Pig Heart Models to Supplement Cardiac Ultrasound Training for Undergraduate Medical Students. T.A. Harvey, D.F. Royer. University of Colorado Denver Anschutz Medical Campus.
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E58 737.1 Comparing First-Year Medical Students Performance on Radiology and Non-Radiology Components of a Gross Anatomy Course. A.D. Ginsburg, J.A. Knight, C.M. Gibbs, P.S. Stadem, W.B. Hoch, J.A. Harvey, P.W. Eiken, N. Lachman, W. Pawlina. Mayo Clinic School of Medicine, Mayo Clinic and Mayo Clinic College of Medicine and Science. E59 737.2 An Authentic Link to the Clinic: Implementation of an Integrated Anatomy-Radiology Curriculum. K. Darras, J. Reeves, A. Roston, J. Hu, S. Nicolaou, B. Forster, C. Krebs. University of British Columbia, Canada and University of Alberta, Canada. E60 737.3 Radiology Touchscreen Kiosks as a Multi-Modal Replacement for the Viewbox. T. Frasch. Tulane University.
738. ANATOMY EDUCATION: PRESERVATION TECHNIQUES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E61 738.1 The Use of Nigrosin Staining to Increase Brain Slice Contrast for Neuroanatomy Teaching. A.N. Saraco, N. MacPhee, A.K. Ball, B.C. Wainman. McMaster University, Canada. E62 738.2 Improving the Quality of Prosected Limbs in Gross Anatomy by Dissecting Under Water. Y. Gao, A.P. Vitela, A. Ransom, S. Alturkustani, A. Reynolds, C. Miller, L. Nieto, R. Ettarh. Tulane University School of Medicine and California University of Science and Medicine. E63 738.3 Educational Advantages to the Use of Soft Fixed Cadavers. G. Smith. Saint Louis University School of Medicine. E64 738.4 The Novel Use of Silicone Dielectric Gel for Central Nervous System Encapsulation and Preservation. P. Persino, K. Samonds, D. Olson, M. Jenkins. Chicago Medical School and Northern Illinois University.
MONDAY ANATOMY
739. ANATOMY EDUCATION: SPATIAL ABILITIES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E65 739.1 Spatial Abilities and Effect of Working Memory on Drawings of Objects from Haptic Perception. J. Langlois, Y. Dagenais, M. Martin, R. Lemieux, M. Lecourtois, J. Bernick, C. Bellemare, E. Yetisir, G. Bergeron, S. Hamstra, G. Wells. CIUSSS de l’Estrie—CHUS, Canada, Université de Sherbrooke, Canada and University of Ottawa, Canada. E66 739.2 Evidence That Studying Histology Improves Students’ Spatial Ability. N.A. Schmalz, K.W. Condon, J.J. Brokaw. Indiana University School of Medicine. E67 739.3 The Creation and Evaluation of a Novel Anatomical Mental Rotation Test for Medical Education Research. M.E. Keeler, M.E. Stabio, D.F. Royer. University of Colorado Anschutz Medical Campus and University of Colorado School of Medicine. E68 739.4 How Learning Methods in Anatomy Allow a Boost of Visuospatial Abilities for Undergraduate Students. V. Defaweux, D. Ernst, A. Dernier, J. Van de Poel, L. Seidel, P. Bonnet. University of Liege, Belgium.
740. CELL BIOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cell Biology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E69 740.1 Widespread Growth Factor Expression in the Reptilian Epidermis Indicates Roles During Homeostasis and Wound Healing. N. Subramaniam, J. Petrik, M. Vickaryous. University of Guelph, Canada. E70 740.2 Characterization of a Non-Canonical Role for Tcf3 in Skin Tumorigenesis. A.T. Ku, H. Nguyen. Baylor College of Medicine. E71 740.3 Cell-Specific Relations Between Vasopressin and Renin-Angiotensin-Aldosterone Systems. Y. Giesecke, T. Giesecke, K. Kawahara, T. Koshimizu, N. Gimber, J. Schmoranzer, S. Bachmann, K. Mutig. CharitéUniversitätsmedizin Berlin, Germany, University of St. Andrews School of Medicine, United Kingdom, Kitasato University School of Medicine, Japan and Jichi Medical University, Japan. E72 740.4 Primary Sertoli Cell Cultures from 30-DayOld Rats Form Cords with a Morphologically Differentiated Phenotype. A. Sriram, H. Huynh, J. Shadarevian, D. Djaksigulova, A. Vogl. University of British Columbia, Canada. E73 740.5 Expression of Prolactin (PRL) in Prostate Gland: Studying Histopathology on Cadaveric Tissue Samples. S. Nomigolzar, N. Khamooshi, L. Sandy, G.M. Nagy. Ross University School of Medicine, Dominica. E74 740.6 The Pattern of VEGF Expression in Avian Renal Development. R.T. McNeil, C.B. Penny. Sefako Makgatho Health Sciences University (SMU) (Formerly called MEDUNSA), Pretoria, South Africa, South Africa and University of the Witwatersrand Medical School, South Africa.
E75 740.7 Immunohistochemical Characterization of Hepatic Progenitor Cell Niche in Liver Fibrosis of Elderly Cadavers. K.M. Mak, S. Chiu. Icahn School of Medicine at Mount Sinai. E76 740.8 Expansion of Hepatic Progenitor Cell Population in Liver Fibrosis of Elderly Cadavers. S. Chiu, K.M. Mak. Icahn School of Medicine at Mount Sinai. E77 740.9 Foetal Intraperitoneal AAV8 Injections as a Valid and Promising Tool to Specifically Target Neuronal Subpopulations Within the Gastrointestinal (GI) Tract. K. Winckelmans, R. Buckinx, S. Waddington, J. Timmermans. University of Antwerp, Belgium and University College London, United Kingdom. E78 740.10 Sexual Dimorphism of Human Vallate Papillae—A Human Cadaveric Study of Normative Morphology. A.A. Rickards, J. Holmes, M.R. Ganoe, K.N. Bliss, M.L. Russell, H.L. Lynch, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E79 740.11 Classification of Vallate Papillae Based upon Morphology and Other Associated Anatomical Features. J. Holmes, A.A. Rickards, M.L. Russell, K.N. Bliss, H.L. Lynch, M.R. Ganoe, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E80 740.12 Analysis of Cellular Responses to Imiquimod in Taste Cells. A.Y. Huang, S.Y. Wu. Southern Illinois University School of Medicine. E81 740.13 Functional and Morphological Characteristics of Efferent Bouton Mitochondria of the Inner Ear. S. Sobkiv, A. Kambalyal, G. Perkins, A. Lysakowski. Univ. of Illinois at Chicago and Univ. of California at San Diego. E82 740.14 Mitochondria Adjacent to Ribbon Synapses in Vestibular Hair Cells Are Not Polarized Toward the Synapse. A. Jayakumar, L. Ghatalah, G. Perkins, A. Lysakowski. University of Illinois at Chicago and University of California at San Diego. E83 740.15 Assessing the Asymmetrical Distribution of Crista Junctions in Tubular Mitochondria Located Adjacent to a Post-Synaptic Density of a Vestibular Hair Cell Ribbon Synapse. S. Vazirian, V. Babu, G. Perkins, A. Lysakowski. University of Illinois at Chicago, Illinois Math and Science Academy, University of California at San Diego. E84 740.16 Mitochondria Near Ribbon Synapses in Inner Ear Hair Cells. L. Ali, A. Jayakumar, G. Perkins, A. Lysakowski. University of Illinois at Chicago and University of California at San Diego. E85 740.17 Energy Output Characteristics of Efferent Bouton Mitochondria of the Inner Ear. A.C. Kambalyal, S. Sobkiv, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California, San Diego. E86 740.18 Structural Analysis of Inner Ear Hair Cell Mitochondria Near the Striated Organelle. J. Lesus, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California, San Diego. E87 740.19 Cristae in Inner Ear Hair Cells Mitochondria Are Polarized Toward Cuticular Plate. K.D. Arias, S.D. Price, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California San Diego. E88 740.20 Cristae Align Across Mitochondrial Membranes in Vestibular Hair Cells to Possibly Increase ATP Output. M.H. Patel, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University California San Diego. E89 740.21 Energy Output of Mitochondria Located Near Synaptic Ribbons in Inner Ear Hair Cells. V. Babu, S. Vazirian, G. Perkins, A. Lysakowski. Illinois Math and Science Academy, University of Illinois at Chicago, University of California, San Diego.
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ANATOMY MONDAY E90 740.22 Polyketide Synthase Is Required for Zebrafish Otolith Biomineralization. K. Thiessen, L. Higuchi, K. Kramer. Creighton University School of Medicine. E91 740.23 Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development. K.L. Kramer, C.J. Inserra. Creighton University.
741. CELL BIOLOGY: MEMBRANES AND CYTOSKELETON Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cell Biology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E92 741.1 Identification and Characterization of Bacterial and Host Factors Involved in Microtubule Disassembly in Epithelial Cells During Edwardsiella Infections. P. Aggarwal, Q. Wang, Q. Liu, K. Leung, J.A. Guttman. Simon Fraser University, Canada, East China University of Science and Technology, People’s Republic of China, and Trinity Western University, Canada. E93 741.2 Palladin Can Compensate for Arp2/3 Complex Defects and Structurally Organizes Actin-Rich Structures Generated during Listeria monocytogenes infections. A.S. Dhanda, A.W. Vogl, C.A. Otey, M.R. Beck, J.A. Guttman. Simon Fraser University, Canada, University of British Columbia, Canada, University of North Carolina and Wichita State University. E94 741.3 The Klebsiella pneumoniae Gene ytfL Triggers Microtubule Disassembly in Lung Epithelial Cells Through KATNA. L1 M.D. Chua, L. Siu, K. Yeh, J.A. Chua. Simon Fraser University, Canada, National Health Research Institutes, Taiwan, Tri-Service General Hospital and National Defense Medical Center, Taiwan. E95 741.4 IP3R, TRPM6 and Homer1 Are Localized to ER-PM Contact Sites at Tubulobulbar Complexes in Rat Testis. A. Adams, A. Vogl. The University of British Columbia, Canada. E96 741.5 IP3R Is Localized to ER-PM Contact Sites at Unique Endocytic Structures Involved in Intercellular Junction Turnover Events Critical to Spermatogenesis. K. Lyon, P. Asghari, D.R. Scriven, E.D. Moore, A. Vogl. University of British Columbia, Canada.
742. DEVELOPMENT AND GROWTH: LIMBS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E97 742.1 Determining the Role of Natural Killer Cells in Immune-Mediated Fetal Growth Restriction in Rats. K. Baines, S. Renaud. The University of Western Ontario, Canada. E98 742.2 The TALLYHO Mouse as a Model of ObesityInduced Linear Growth Acceleration. C.A. Meadows, J. Kim, S. Arthur, G. Ion, H.L. Racine, J.C. Kerby, M.A. Serrat. Marshall University Joan C. Edwards School of Medicine.
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E99 742.3 Lmx1b-Dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation. L.A. Ivey, E. Haro, C.U. Pira, K.C. Oberg. Loma Linda University. E100 742.4 Identification of a Novel Silencer Within an Lmx1b Mediated Cis-Regulatory Module. A.L. Gray, E. Haro, C.D. Spady, C.U. Pira, K.C. Oberg. Loma Linda University. E101 742.5 Analysis of Sp6 and Sp8 Protein-Protein Interactions and DNA Binding During Limb Development. M. Ros, R. Pérez-Gómez, M. Fernández-Guerrero, S. Zunzunegui, S. Bell, J.F. López-Giménez. Instituto Biomedicina y Biotecnologia de Cantabria, Spain, Universidad de Cantabria, Spain and Cincinnati Children’s Hospital Medical Center Cincinnati. E102 742.6 Chondrocyte Columns Are Shorter in the Growth Plate of Collagen XXIV Null Mice. M. Gordon, P. Zhou, R. Hahn, D.R. Gerecke. Rutgers University.
743. DEVELOPMENT AND GROWTH: CRANIOFACIAL Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E103 743.1 Cadherin-6B Proteolysis Controls the Neural Crest Cell Epithelial-to-Mesenchymal Transition Through Transcriptional Regulation. L. Taneyhill. University of Maryland. E104 743.2 Cell Migration and Palatal Fusion. S. Logan, D. Benson. Texas A&M University College of Dentistry. E105 743.3 In Vivo Inhibition of microRNA (miR) Using a Novel miR Inhibitor System Reveals a Role for miR-17-92 in Palate Elevation and/or Extension. R.J. Ries, W. Yu, S.L. Eliason, H. Cao, B.A. Amendt. University of Iowa Carver College of Medicine and University of Iowa College of Dentistry. E106 743.4 Analysis of Craniofacial Variation in cleft secondary palate-1 Heterozygous and Homozygous Newborn Mice. H. Bennett, R. Moskal, J. Holloway, J. Jones, N. Holton, E. Leslie, B. Bjork. Midwestern University and University of Iowa. E107 743.5 Cleft Palate Case-Derived ARHGAP29 Mutation Causes Lethality and Oral Adhesions in Mice. B.J. Paul, K. Palmer, J.C. Sharp, C.H. Pratt, S.A. Murray, M. Dunnwald. University of Iowa and The Jackson Laboratory. E108 743.6 Gene Expression of Angiogenesis Markers in Mouse Mandibular Condyle During Development. I. Sato, Y. Maeda, Y. Miwa, M. Sunohara. The Nippon Dental University, Japan. E109 743.7 FGF8 Dosage and Tissue Interactions Contribute to Jaw Asymmetry in Disease. J.L. Fish, K. Dolan, R. Green, R.S. Marcucio, B. Hallgrimsson. UMass Lowell, University of Calgary, Canada and UCSF. E110 743.8 A Sox2-Lef-1 Protein Interaction Inhibits Lef-1 Transcriptional Activity and WNT Signaling During Odontogenesis. M.E. Sweat, W. Yu, S. Eliason, B.A. Amendt. University of Iowa, Craniofacial Anomalies Research Center and Carver College of Medicine. E111 743.9 Do Secretory-Stage Ameloblasts Divide? Experimental Evidence. R. Hogg, T. Smith, N. Ward, S. Gografe. Florida Gulf Coast University, Slippery Rock University and Florida Atlantic University.
MONDAY ANATOMY E112 743.10 Pitx2 Controls Dental Stem Cell Proliferation and Differentiation by Regulating Cyclin D2 and Irx1. W. Yu, Z. Sun, S. Eliason, B.A. Amendt. The University of Iowa. E113 743.11 microRNA-26b-5p Targets Lef-1 to Regulate Molar and Incisor Development. S.L. Eliason, M.R. Bustillo, N. Holton, B.A. Amendt. University of Iowa. E114 743.12 Skull and Aerodigestive Tract Growth in Early Postnatal Life: Establishing a Sample. D.F. Curcio, J. Delgado, J.T. Meaike, A. Gupta, K. Zur, K. Shekdar, J.T. Laitman. Icahn School of Medicine at Mount Sinai, Santa Casa School of Medical Sciences—Sao Paulo, Brazil and The Children’s Hospital of Philadelphia. E115 743.13 The Back to Sleep Campaign, Positional Cranial Deformity, and the Foramen Magnum: New Lessons Learned from Old Pachacamac Crania. M.J. Zdilla, A.W. Koons, M.L. Russell, K.N. Bliss, K.R. Mangus. West Liberty University. E116 743.14 Fluorescent Labeling in the Leopard Gecko Resolves Tooth Initiation Patterns in Ovo and Suggests Origins of Post-Hatching Shedding Patterns. T.M. Grieco, K.S. Brink, J.M. Richman. University of British Columbia, Canada.
744. NEUROBIOLOGY: NEURONAL AND SPINAL CORD DEGENERATION, REPAIR AND REGENERATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E117 744.1 Homeostatic Neurogenesis in the Lizard Brain. R.P. McDonald, M.K. Vickaryous. University of Guelph, Canada. E118 744.2 Distribution of Neural/Stem Progenitor Cells in the Brain of the Leopard Gecko (Eublepharis macularius). R.P. McDonald, S.S. Bradley, M.K. Vickaryous. University of Guelph, Canada. E119 744.3 Peripheral Blood Neutrophil Activity Profiles in Dogs with Spinal Cord Injuries: A Longitudinal Analysis. R.L. Russell, C. Welsh, N.D. Jeffery, C.R. Young, G.J. Levine, J.M. Levine. Texas A&M University. E120 744.4 Neuron-Specific Transgene Expression of IMP2 Mediated by Synapsin Promoter-Driven AAV9. D. Park, S. Blizard, S. Austin, J. Harman, S. Haraszti, M. Xu. Philadelphia College of Osteopathic Medicine. E121 744.5 Investigating UBA1 Distribution and Its Relevance to Spinal Muscular Atrophy. A. Maani, H. Shorrock, T. Gillingwater. The University of Edinburgh, United Kingdom. E122 744.6 (Z)-Bisdehydrodoisynolic Acid (BDDA), a Non-Steroidal Uterotrophic and Potentially Neuroprotective Compound in Brain Injury, Induces Proestrus-Like Luteinizing Hormone Secretion and Lordosis Behavior in Ovariectomized Female Rats. R.W. Clough, N.S. Viscomi, L. Arbogast, Y. Hou, W.J. Banz. Southern Illinois University School of Medicine and Southern Illinois University Carbondale. E123 744.7 Trigeminal Neuralgia in Rats with Hypothyroidism: A Morphological Study. O.P. Sobrinho, H.F. Silveira, L.A. Vieira, K.O. Sousa, D.B. Dias, D.V. Gondim, M.L. Vale. Universidade Federal do Ceará, Brazil.
E124 744.8 Changes in the Extracellular Matrix Following Ischemic Stroke in the Rat. M. Patel, A. McClain, A. Meyer, E. Andrews. Midwestern University. E125 744.9 Therapeutic Effects of Long-Term Systemic Adipose-Derived Stem Cell Conditioned Medium in a Mouse Model of Amyotrophic Lateral Sclerosis. C.L. Walker, F.M. Kennedy, C.M. Fry, A.K. Iyer, Y. Du, K. March, K.J. Jones. Indiana University School of Medicine and Roudebush VA Medical Center.
745. NEUROBIOLOGY: BEHAVIOR; NEUROPSYCHIATRIC DISORDERS; DISEASE; AGING Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E126 745.1 DNA Methylation and mRNA Expression in the dmPFC Are Altered After Protracted Withdrawal from Cocaine Self-Administration. K. Ploense, P. Vieira, T. Kippin. UC Santa Barbara. E127 745.2 Expression of Glial Fibrillary Acidic Protein (GFAP) and Histopathological Changes in Brains of Trypanosoma brucei brucei Experimentally Infected Rats. J.N. Alawa, J.S. Maliki, Y. Tanko, C.I. Alawa. Ahmadu Bello University, Nigeria and University of Abuja, Nigeria. E128 745.3 Serum Enkephalin Levels Correlate with EAE Disease Severity. M.D. Ludwig, I.S. Zagon, P.J. McLaughlin. Pennsylvania State University College of Medicine. E129 745.4 Withdrawn. E130 745.5 Amphetamine-Induced Hyperlocomotor Activity in Heterozygous Disc1 Mutant Mice. C. Lai, L. Lee. National Taiwan University, Taiwan. E131 745.6 Different Expression of miRNA in the Elderly with Cognitive Impairment and Control Group in Aluminum Exposed Mining Area. H. Ma, H. Huang, L. Tang, S. Zhou, B. Chen, Y. Ling. Youjiang Medical University for Nationalities, People’s Republic of China. E132 745.7 Cognitive Function in Varsity Football Athletes Is Maintained in the Absence of Concussion. D. BrewerDeluce, T. Wilson, A.M. Owen. Western University, Canada.
746. NEUROBIOLOGY: DEVELOPMENT Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E133 746.1 Vexin (Vxn) Regulates Neurogenesis and Cell Cycle Exit Downstream of Proneural Factors. K. Moore, M. Logan, I. Al Diri, M. Steele, M. Vetter. University of Utah and Oregon Health Sciences University.
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ANATOMY MONDAY E134 746.2 Ronin (Thap11) Is Implicated in a New Cobalamin Deficiency Syndrome Impacting the Central Nervous System. A. Achilleos, X. Tong, R.A. Poché. Baylor College of Medicine. E135 746.3 Morphological and Physiological Characterization of Cortical Subplate Neurons in ForebrainSpecific Ctgf Knockout Mice. Y. Lu, L. Lee. National Taiwan University, Taiwan. E136 746.4 Motor Neuron Scaling and Somatic Growth in Normal and Transgenic Rainbow Trout, Oncorhynchus mykiss. C.W. Anderson, E.T. Feurborn, T.M. Bradley, K.J. Rodnick. Idaho State University and University of Rhode Island.
747. NEUROBIOLOGY: NEUROPROTECTION AND NEUROIMMUNOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E137 747.1 ‘Gene Expression Profile Analysis of Immunodeficient Mice After WT or mSOD1 Immunoreconsitution Reveals Differential Motoneuron Death Mechanisms After Facial Nerve Axotomy. D.O. Setter, E.M. Runge, N.D. Schartz, V.M. Sanders, K.J. Jones. Indiana University School of Medicine, Roudebush VAMC and The Ohio State University. E138 747.2 Swine Barn Dust Exposure Activates Microglia Through Induction of Oxidative Stress and the Resultant Neuroinflammation Appears to Involve HMGB1 and RAGE Signaling. N. Massey, S. Puttachary, S. Mahadev-Bhat, D. Shrestha, A.G. Kanthasamy, C. Charavaryamath. Iowa State University. E139 747.3 Effects of Dietary Isoflavones, Age, and Stroke on Estrogen Pathway Activation in Male Rats. M.L. Hart, K. Huber, E.D. Grisley, J.L. Cheatwood. SIU School of Medicine. E140 747.4 Withdrawn.
748. ANATOMY: NEURAL Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E141 748.1 Cutaneous Innervation of the Palmar Aspect of the Hand. M. Hurley, T. Stevens, R. Fracassi, D. Neu, M.P. Olivieri. D’Youville College. E142 748.2 Nerval Danger Zones for Surgical Procedures of the Arm and the Forearm. L. Hirtler, V. Wlodek. Medical University of Vienna, Austria. E143 748.3 Baxter’s Nerve Impingement and Other Neuropathies of the Foot: Implications for Physical Therapy. B.J. Hornick, A.H. Amabile. Thomas Jefferson University.
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E144 748.4 A Study to Determine the Incidence and Examine the Implications of Phrenic Nerve Dysfunction in Cervical Spine Hyper-Flexion/Extension Injury. K.A. Turner, D. Walton, M. Johnson, K. Willmore, T. Wilson. Western University, Canada. E145 748.5 The Ligamentum Flavum Thickens During the Advanced Stages of Hypomobility Induced Lumbar Spinal Osteoarthritis. T. Pulisetty, A.N. Benckendorf, J.A. Merlo, G.D. Cramer, J.W. Little. Saint Louis University School of Medicine and National University of Health Sciences. E146 748.6 The Lumbar Facet Joint Synovial Fold Intimal Surface Length Decreases During the Onset of Cartilage Degeneration Following Spinal Hypomobility. J.M. Allison, J.A. McDowell, J.A. Merlo, G.D. Cramer, J.W. Little. Saint Louis University School of Medicine and National University of Health Sciences. E147 748.7 Identification of the Neurotransmitter Substance P in Sural Nerve of Rats: An Immunohistochemistry Approach. C. Giorgetto, A.B. Simoes, V.S. Fazan. School of Medicine of Ribeirao Preto, Brazil. E148 748.8 Decreases in Relative Cerebellum Volume Are Correlated with Digit Reduction and Limb Loss in Squamates. C.P. Heesy, M.I. Hall, S.A. Ruiz, N.Wells. Midwestern University. E149 748.9 Morphological Comparison of the Pudendal Canal and Its Neurovascular Elements in Human and Domestic Mammals. J.R. Rodriguez-Sosa, M.I. Hall, J.H. Plochocki, S.A. Ruiz, B. Adrian. Arizona College of Osteopathic Medicine, College of Veterinary Medicine, Midwestern University and Arizona College of Osteopathic Medicine Midwestern University. E150 748.10 Neuroanatomical Variants of Clinical Importance in the Population of Ethiopia. A.T. Wirtu, S.A. Geneti, S.T. Haile Georgis, J.M. Gemechu. Addis Ababa University School of Medicine, Ethiopia and Oakland University William Beaumont School of Medicine.
749. NEUROBIOLOGY: BRAIN Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: 12:00 pm–2:00 pm E151 749.1 Embryo-Form Project : How Accurate Was Miss D. Padget? Study of the Human Venous Cerebral System. R. Tonnelet, Y. Renard, E. Micard, M. Fauvel, M. Perez, M. Labrousse, M. Braun. CHU Nancy, France, Faculté de Médecine Université de Lorraine, France and Faculté de Médecine—Université de Reims Champagne Ardenne, France. E152 749.2 Blood Supply to the Human Dentate Nucleus by Cerebellar Arteries. S. Kim, H. Yang, Y. Lee, H. Kim, H. Lee. Yonsei University College of Medicine, Republic of Korea, Gachon University Medical School, Republic of Korea, Department of Radiology, Yonsei University College of Medicine, Republic of Korea. E153 749.3 Diversity of Microvascular Endothelial Cell Markers in Different Regions of the Human Brain. S. Mbagwu, L. Filgueira. University of Fribourg, Switzerland and Nnamdi Azikiwe University, Nigeria. E154 749.4 Sleep, Glymphatic Activation and Phantosmia Inhibition. R.I. Henkin, M. Abdelmeguid. Center for Molecular Nutrition and Sensory Disorders.
MONDAY BIOCHEMISTRY
Biochemistry and Molecular Biology 750. EDUCATION AND PROFESSIONAL DEVELOPMENT THROUGH THE ACADEMIC AND CAREER PIPELINE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B1 750.1 Assessing Accreditation at the ASBMB: Surveying Our Constituency. J.T. Tansey, L. Carastro, D.M. Dean, P. Kennelly, D. Martin, A.J. Wolfson, J.J. Provost. Otterbein University, The University of Tampa, The University of Saint Joseph, The Virginia Polytechnic Institute, St. Mary’s University of Minnesota, Wellesley College and The University of San Diego. B2 750.2 An Effective Workshop Model for Graduate Student and Postdoctoral Fellow Career Development. S. Feeney, J.M. Barral, J.M. Hendershot, G. Hunt, E.A. Siebrasse. University of California at Davis, The University of Texas Medical Branch, Cayman Chemical Company and American Society for Biochemistry and Molecular Biology. B3 750.3 Use of Eyetracking Technology to Determine Biochemistry Expert-Novice Differences in Reading Metabolic Pathways. K. Linenberger Cortes. Kennesaw State University. B4 750.4 Support and Expectations for Biochemistry and Molecular Biology Faculty Promotion and Tenure at PUI Institutions. K.L. Cortes, R.L. Angotti, J. Provost, M.A. Benore. Kennesaw State University, University of Washington Bothell, University of San Diego and University of Michigan Dearborn. B5 750.5 MAMS–A Biochemistry and Molecular Biology Rich Bridge Program to Health Professional School. M.A. Taylor. Pacific Northwest University of Health Sciences and Heritage University. B6 750.6 First Year Medical Student Authorship of Clinical Cases. R.C. Bateman; Jr., P. Chastain, M. Stephens. WCU College of Osteopathic Medicine and UI College of Medicine at Rockford. B7 750.7 Mental Health Crisis in Graduate Education: The Data and Intervention Strategies. T.M. Evans, L. Bira, J. Beltran-Gastelum, L. Weiss, N. Vanderford. UT Health San Antonio, St. Mary’s Univ. and Univ. of Kentucky. B8 750.8 Using Collaborative Problem Sets to Facilitate Learning in the Online Thermodynamics Classroom. D. Dean. University of Saint Joseph. B9 750.9 Mentorship Training for Postdoctoral Researchers: Results from a Four Week Intervention Program. C.G. Pena, T. Evans, S. Mustafa, L. Moreno, L. McManus. UT Health.
B10 750.10 The Women in Science Undergraduate Organization at Otterbein University: Best Practices and Outreach Efforts. T.B. Hyatt, H.M. Bailey, J.T. Tansey. Otterbein University. B11 750.11 A Potential Solution to the Continuing Problem of Not Enough NIH RO1 Funding to Minority Investigators. J.J. Guers, J. Gwathmey, G. Haddad, D.E. Vatner, S.F. Vatner. Rutgers University—New Jersey Medical School and Howard University.
751. ENGAGING AND RETAINING STEM STUDENTS IN THE LEARNING PROCESS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B12 751.1 Structural Modeling and 3-D Printing of the PTF1-L Heterotrimeric Complex: Understanding the Structure and Function of a Ptf1a P191T Hypomorphic Mutation That Causes Pancreatic Aplasia in Children. L. Davies, C. Zwillenberg, J. Diaz, S. Nelson, A. Ali, S. Staford, T. Lefeld, M. Bowers, A. Gilliam, S. Hooks, E. Maysent, H. La Force, J. McKenzie, V. Armenta, I. Baker, C. Bennette, L. De Leon, A. Escobar, R. Faulkner, L. Morel, W. Morel, A. Garcia, M. Garcia, N. Grimes, I. Hernandez, E. Jordan, Y. Martinez, L. Montelongo, K. Montes, S. Njoku, A. Pacheco, M. Pittman, V. Pittman, E. Sandoval, E. Santana, H. Starnes, D. Morales, M. Flores, L. Tudon, A. Burkhaulter, N. Ali, W. Coats, R. MacDonald. Hillcrest High School and University of Texas Southwestern Medical Center at Dallas. B13 751.2 Predictors of Success on the MCAT for PostBaccalaureate Pre-Medicine Students. Y. Dobrydneva, L. Schwartz. GWU School of Medicine and Health Sciences. B14 751.3 Design and Implementation of an Experiential Learning Workshop for Upper-Level Undergraduate Science Majors. S.J. Connelly, R. Johnson, J.L. Mills. Rochester Institute of Technology. B15 751.4 Modeling a Protein Story (MAPS): A ProjectBased Learning Program Connecting Gene and Protein Sequence and Structure-Function Relationships with Physical Models. D.H. Munzenmaier. Milwaukee School of Engineering. B16 751.5 The Evolution of Hemocyanin. M. Schuld, R. Bhatia, S. Bobber, B. Dorava, B. Fragoso, O. Johanneck, K. Ledger, B. Mclaughlin Haralson, A. Mitchell, J. Perez, T. Rivera, J. Ruiz, S. Sheikh, A. Ya, J. Perez. Ronald Wilson Reagan College Preparatory High School. B17 751.6 Withdrawn. B18 751.7 Making Connections: Impact of Primary Literature Assignments on Lecture and Laboratory Learning. K.R. Miller. University of Mount Union.
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BIOCHEMISTRY MONDAY B19 751.8 Promoting Rural Student Enthusiasm for STEM by Establishing a Model Biotechnology Company in Their High School. M. Koci, B. Boller, R. Ali, A. Orders. NC State University and Bertie Early College High School. B20 751.9 IONiC VIPEr: Online Resources for an Active Classroom in Bioinorganic Chemistry. S. Smith, A. Bentley, H.J. Eppley, E. Jamieson, A.R. Johnson, C. Nataro, J. Raker, B.A. Reisner, J.L. Stewart, L.A. Watson, N.B. Williams. University of Michigan-Dearborn, Lewis and Clark College, DePauw University, Smith College, Harvey Mudd College, Lafayette College, University of South Florida, James Madison University, Hope College, Earlham College, Claremont McKenna, Pitzer and Scripps Colleges. B21 751.10 Integrating Research Experiences Into Introductory Biology Laboratories to Engage Undergraduate Students in STEM Learning. D. Zies, M. Stebar, D. Baker. University of Mary Washington. B22 751.11 Scientific Community Outreach in Central Texas. J.A. Bondoc, J. Ream. Texas State University. B23 751.12 Observations and Practical Tips on Metal Affinity Chromatography and Protein Refolding Techniques. C.N. Tovar, J.A. Mullins, O.O. Odunuga. Stephen F. Austin State University. B24 751.13 A Topic-Based Approach for Teaching Metabolism in a Flipped Classroom. K.E. Johanson. Xavier University of Louisiana. B25 751.14 Flipped Classroom Approaches Lead to No Improvement in Learning Outcomes or Student Perceptions. J.A. Arnott, S.L. Planey. The Commonwealth Medical College. B26 751.15 Proxies for Success—How Application Changes Correlate to PhD Path Pursuit for a Small Diversity Research Program. C.R. Shadding, D. Whittington. Washington University in St. Louis—School of Medicine, Strategic Evaluations and Inc.
752. LABORATORY COURSES
B30 752.4 Ammonium Sulfate Selectively Extracts Invertase Activity from a Mixture of Precipitated Yeast Proteins. R.M. Cook, A.J. Gontkovic, J. Lawrence, A. Timerman. University of Wisconsin-Stevens Point. B31 752.5 The Role of Skill Assessments in an Undergraduate Non-Majors Biochemistry Lab Course. O.M. Hart. Purdue University. B32 752.6 Genetic Engineering of Human Cells Using Lentivirus in a High School Laboratory Course. C. Safranek, E. Ross, M. Rosenberg, A. Cole, A. Chandra, L. Pemberton, H. Zarrinnegar, A. Alonzo, L. De, R. Sweeney. The Nueva School. B33 752.7 Establishing a Zebrafish Laboratory Exercise to Be Used in a Course-Based Undergraduate Research Experience (CURE) in Introductory Biology. L. Bruton, A. Gruber, K. Kalo, J. Morrissette. Lawrence Technological University. B34 752.8 Undergraduate Student Research in Quantitative Analysis of Transcription Elongation Perturbation Networks Using Mass Spectrometry. L. Bedard, A. Boyd, N. Dyer, Z. Golay, W. Smith-Kinnaman, N. Alakhras, A.L. Mosley. DePauw University and Indiana University School of Medicine. B35 752.9 Design of a Robust Undergraduate Biochemistry Laboratory Course Based on a Modified and Expanded Bovine Serum Albumin Purification Scheme. T. Odunuga, N. Cheatwood, J. Mullins, M. Harris. Stephen F. Austin State University. B36 752.10 Design and Implementation of a SemesterLong Course-Based Research Experience in Biochemistry That Is Suitable for Introductory and Upper Level Students. S. Shelby. Florida Southern College. B37 752.11 Adaptation of Conceptual Frameworks from Public Health to Promote Deeper Learning in a Biochemistry Lab Course Curriculum. B. Smith-Keiling. University of Minnesota.
753. DNA REPLICATION
Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B27 752.1 Measurement of BCAA in Milks and Supplements with an Enzyme Assay: Confirmation of Results with HPLC. K. Keenan, D. Do, K. Ngo. Stockton University and Absegami High School. B28 752.2 A POGIL Based Laboratory Manual for Undergraduate Biochemistry. A. Wright, B. Davis, A. Krzyslak. Marymount University, Shenandoah University and Bellarmine University. B29 752.3 Assessing Student Competencies Using Rubrics Associated with Figure Legends and Ability to Perform the Bradford Assay in a 400-Level Undergraduate Course on Proteomics. R. Shipman, J. Grant. University of Wisconsin-Stout.
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Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B38 753.1 A Novel Reductase-Independent Role of Nuclear Ribonucleotide Reductase. Y. Aye. Cornell U & Weill Cornell Med. B39 753.2 Bypass and Misincorporation of DNA Polymerases at DNA-Peptide Crosslinks. C.A. Sedgeman, F.P. Guengerich. Vanderbilt University. B40 753.3 Defining Lagging-Strand Polymerase Dynamics in Vivo. D. Smith. New York University. B41 753.4 Mechanism of DNA Binding by Human DNA Ligase 1. T. Jurkiw, P. O’Brien. University of Michigan. B42 753.5 An Evolutionary Conserved DNA Replication Stress Response in Planarian. R. Tirgar, U. Shamoon, L. Akpati, N. Sawyer, E. Nam. University of Saint Thomas.
MONDAY BIOCHEMISTRY B43 753.6 Single Amino Acid Substitutions Affect the Stability of the Dimer Interface of the E. coli β Clamp. J. Baez. Colgate University. B44 753.7 Acetylpyrazine Thiosemicarbazone Inhibiting Topoisomerase II. L.C. Ngo, G. Stults. Tennessee Technological University.
754. DNA DAMAGE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B45 754.1 Assessing DNA Cross-Linking and Repair in Human Leukemia Cells. P.M. Le, J.T. Millard. Colby College. B46 754.2 Determination of Escherichia coli Genes Important for Dna Repair Following Alkylation. C. Joshi, A. Aiken, E. Nash, K. Wong, A. Carlson, B. Leifer, M. Muenter, P. Beuning. Northeastern University. B47 754.3 Effects of DNA Bending on T=C CPD Deamination. K. Wang, J. Taylor. Washington University in St. Louis. B48 754.4 A Dipyrimidine Sequence Library for Determining the Sequence Dependence of UV-Induced Cyclobutane Pyrimidine Dimer Formation. C. Lu, J.-S. Taylor. Washington University in St. Louis. B49 754.5 Effects of H4K16 and Gene Mutation on Sensitivity to DNA Damaging Agents and Silencing. B. Enya, T. Young, A. Kirchmaier. Savannah State University and Purdue University. B50 754.6 Determination of E. coli Cellular Factors That Contribute to Survival upon Exposure to the Alkylating Agent Benzyl Bromide. A. Aiken, S. Bellou, K. Wong, E. Nash, C. Kramer, B. Leifer, M. Muenter, P. Beuning. Northeastern University. B51 754.7 Identification of the Dimer Exchange Interface of the Bacterial DNA Damage Response Protein UmuD. D.A. Murison, R. Timson, P. Beuning. Northeastern University. B52 754.8 A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells. M.K. Zafar, L. Maddukuri, N.R. Penthala, A. Ketkar, S. Eddy, M.R. Reed, P.A. Crooks, R.L. Eoff. University of Arkansas for Medical Sciences. B53 754.9 Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment. M.R. Reed, L. Maddukuri, E. Helm, A.C L. Bostian, M.K. Zafar, R.L. Eoff. University of Arkansas for Medical Sciences, University of Central Arkansas and Arkansas State University.
755. HISTONE MODIFICATIONS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B54 755.1 Chemical Tools to Study the Molecular Mechanisms of the CoREST Complex-Chromatin Interactions. M. Wu, D. Hayward, J.H. Kalin, Y. Song, J.W. Schwabe, P.A. Cole. Johns Hopkins University School of Medicine and University of Leicester, United Kingdom. B55 755.2 Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. D. Zhang, Z. Xie, D. Chung, Z. Tang, H. Huang, L. Dai, S. Qi, J. Li, G. Colak, Y. Chen, C. Peng, H. Ruan, D. Wang, L.M. Jensen, O. Kwon, S. Lee, S.D. Pletcher, M. Tan, D.B. Lombard, K.P. White, H. Zhao, J. Li, R.G. Roeder, X. Yang, Y. Zhao. Medical University of South Carolina, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China, University of Minnesota Twin Cities, Yale University School of Medicine, University of Michigan, Kyungpook National University, Republic of Korea, Yale University and Yale School of Medicine. B56 755.3 A “Tail” of Unusual Histone H2A Variants in Bdelloid Rotifers. M. Ebijoyeldhas, A.C. Jones, M. Boerma, S.D. Byrum, L.M. Orr, A.J. Tackett, A. Schurko. Hendrix College and University of Arkansas for Medical Sciences. B57 755.4 Systematic Mutational Analysis of Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Active Site Suggests Single Phe/tyr Switch Position to Regulate Product Specificity. A. Canning, N. Alicea-Velazquez, M. Cosgrove. SUNY Upstate Medical University. B58 755.5 Discovering Selectivity in BET Bromodomain Epigenetic Regulation. M. Olp. Medical College of Wisconsin. B59 755.6 Identification of Inhibitors of Human Histone Methyltransferases SUV39H1 and SUV39H2. A.C. Spencer, A. Jahan, Z. Shaikh, K. Liu. Augusta University. B60 755.7 Biological Function and Histone Recognition of Family IV Bromodomain-Containing Proteins. J.T. Lloyd, A. Poplawaski, M.Y. Lubula, S. Carlson, J. Gay, K.C. Glass. Albany College of Pharmacy and Health Sciences (Vermont Campus). B61 755.8 Class I-Specific HDAC Inhibitor Stimulates the Expression of Npr1 in Haplotype Mice by Enhanced Histone Acetylation at Different Lysine Residues. P. Kumar, V.R. Gogulamudi, C. Nguyen, K.N. Pandey. Tulane University Health Sciences Center and School of Medicine. B62 755.9 Regulation of Histone Methylation via Methionine Metabolism. S.A. Haws, J.M. Denu. University of Wisconsin-Madison, Wisconsin Institute for Discovery and University of Wisconsin-Madison School of Medicine and Public Health. B63 755.10 A Novel “Dual Substrate” Kinetics Assay Suggests the Presence of Two Active Sites in the MLL1 Core Complex. K. Namitz, J. Mahmud, N. Alicea-Veláquez, M. Cosgrove. SUNY Upstate Medical University.
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BIOCHEMISTRY MONDAY B64 755.11 Molecular Characterization of UHRF1 and UHR. F2 A. Winkler, B. Albaugh. Eastern Michigan University. B65 755.12 Molecular Characterization of the PHD Domains of UHRF1 and UHRF2. A. Mohamed, B. Albaugh. Eastern Michigan University. B66 755.13 Affinity Characterization of TTD Domain of UHRF Histone Reader Protein. T.S. Petzold. Eastern Michigan University. B67 755.14 Identifying Dysregulated Epigenetic Enzymes in Castrate-Resistant Prostate Cancer Development. J. Lee, B.H. Yang, N.H. Damaschke, M.D. Boersma, W.H. Huang, E. Corey, D.F. Jarrard, J.M. Denu. University of Wisconsin— Madison, Auburn University and University of Washington. B68 755.15 GPS2 Regulates Mitochondrial Biogenesis via Mitochondria Retrograde Signaling and Modulation of NuclearEncoded Mitochondrial Genes Core Promoter Accessibility. M.D. Cardamone, B. Tanasa, C.T. Cederquist, J. Huang, K. Mahdaviani, J.L. Orofino, C. Lentucci, W. Li, M.G. Rosenfeld, M. Liesa, V. Perissi. Boston University, Stanford University, University of California Los Angeles and University of California San Diego. B69 755.16 The Effect of UVB Irradiation on Histone H4. C.R. Musson, C. Zurita-Lopez. California State University at Los Angeles. B70 755.17 New Method for Isolation of Native Yeast Nucleosomes—Development and Application. V.I. Kuznietsov, C.A. Fox, J.M. Denu. University of Wisconsin-Madison. B71 755.18 Understanding the Role of the Histone Demethylase LID in the SIN3 Histone Modifying Complex in Drosophila melanogaster. A. Chaubal, L. Pile. Wayne State University.
756. TRANSCRIPTIONAL REGULATION (I) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Transcriptional Regulation (II), Tuesday B72 756.1 Biochemical Analysis of the Zinc Uptake Regulator (Zur) from Klebsiella oxytoca. L. Khacheryan, Y. Xie, G. Gallas, J. Hernandez. Midwestern University. B73 756.2 Biochemical Analysis of Zinc Transporter Regulator from Klebsiella oxytoca: In Vitro and in Vivo Effects on Protein Function. Y. Xie, L. Khacheryan, G. Gallas, J. Hernandez. Midwestern University. B74 756.3 Upregulation of CYP17A1 by Sp1-Mediated DNA Demethylation Confers Temozolomide Resistance Through DHEA-Mediated Protection in Glioma. T. Hsu. Taipei Medical University, Taiwan.
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B75 756.4 The Sp1 in Astrocyte Plays an Important Role in Neurogenesis. J. Hung, W. Chang. Department of Biotechnology and Bioindustry Science, NCKU, Taiwan, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei Taiwan. B76 756.5 Transcriptional Regulation by Mediator Kinases During Starvation or Proliferation. J.D. Rubin, R.D. Dowell, D.J. Taatjes. University of Colorado Boulder. B77 756.6 Heme Induces HAP4 Transcription and Mitochondrial Respiration. T. Zhang, A. Vancura. St.John’s University. B78 756.7 Zinc-Dependent Transcriptional Regulation in Paracoccus denitrificans. D.P. Neupane. New Mexico State University. B79 756.8 Stat3 Is a Upstream Regulator of Granzyme g That Triggers the Minor Zygotic Gene Activation in Mouse Preimplantation Embryo. H. Ou-Yang, S. Wu, L. Sung, C. Chen. Institute of Biotechnology, National Taiwan University, Taiwan, Department of Animal Science and Technology, National Taiwan University, Taiwan, Department of Life Sciences and National Chung Hsing University, Taiwan. B80 756.9 Using Artificial Transcription Factors to Induce Differentiation into Cardiomyocytes. E.A. Heiderscheit, A. Eguchi, M.J. Wleklinski, M.C. Spurgat, A.Z. Ansari. University of Wisconsin—Madison. B81 756.10 The Role of Noncoding Genetic Elements in the Transcriptional Regulation of the Voltage-Gated Sodium Channels SCN1A and SCN8A. G.S. Inglis, A. Escayg. Emory University. B82 756.11 An Analysis of Cycling DOF Factor-Like Genes and Their Expression in Physcomitrella patens. J.C. Pang, K.A. Hicks. Kenyon College. B83 756.12 O-GlcNAc Regulates Erythroid Genes Controlled by GATA-1. Z. Zhang, S. Graw, E. Tan, D.C. Koestler, K.R. Peterson, C. Slawson. The University of Kansas Medical Center. B84 756.13 Elucidating a Putative Enhancer Element for the Human LAT Gene. G. Ghanim, T.S. Finco. Agnes Scott College. B85 756.14 Rdl Expression Impacts Circadian Rhythm and Locomotion in Drosophila melanogaster. S. MacDonald, R.P. Rogers. Wentworth Institute of Technology. B86 756.15 Molecular Characterization of HlyU, a Global Regulator of Vibrio vulnificus Virulence Genes. S. Choi, Z. Lee, Y. Bang, K. Jang. Seoul National University, Republic of Korea, and UT Southwestern Medical Center. B87 756.16 Smad4-Dependent TGF-β Signaling Directly Up-Regulates Notch Receptor in Cerebrovascular Endothelial Cells. Y. Lan, X. Cheng. Institute of Biotechnology, People’s Republic of China, Institute of Biotechnology, People’s Republic of China. B88 756.17 Regulation of Cellular Proliferation in B-Cell Acute Lymphoblastic Leukemia by Ikaros. E. Dovat, J.L. Payne, C. Song, D. Desai. Pennsylvania State University and Pennsylvania State University College of Medicine.
MONDAY BIOCHEMISTRY B89 756.18 Transcriptional Regulation of Cell Cycle Progression in T-Cell Leukemia. J.L. Payne, M. Soliman, E. Dovat, M. Kapadia, C. Song, S. Dovat. Loma Linda University School of Medicine and Penn State College of Medicine. B90 756.19 MSK-1 Mediated Histone H3 Phosphorylation Is Critical for Ethanol-Induced Inhibition of IL-2 Gene Transcription in CD4+ T Lymphocytes. S. Ghare, S. JoshiBarve, C. McClain, S. Barve. University of Louisville and Robley Rex VAMC. B91 756.20 Inhibiting Pathways Involved in B-Cell Development Enhances Sensitivity of B-Cell Acute Lymphoblastic Leukemia to Glucocorticoids. M.A. Pufall, K. Kruth, M.A. Fang, D. Shelton, O. Abu-Halawa, S.K. Tasian, M. Kampmann. University of Iowa, Bio-Rad, Coe College, Children’s Hospital of Philadelphia, University of California San Francisco.
757. NON-CODING RNAS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B97 757.1 Targeting High-Mobility Group Box2 by miR-127 Modulates Pluripotency of Mouse Embryonic Stem Cells and Contributes to Aggressiveness of Hepatocellular Carcinoma. Y. Zhao, Z. Yang, L. Wang. University of Connecticut, Veterans Affairs Connecticut Healthcare System and Yale University. B98 757.2 Tthe Role of LncRNA H19 in Estrogen-Induced Cholestatic Injury. X. Li, R. Liu, D. Zhao, W. Pandak, P. Hylemon, H. Zhou. Virginia Commonwealth University. B99 757.3 miRNA-Mediated Crosstalk Between Wnt3a and TGFβ3 in Osteoblast Differentiation. S. Fushimi, T. Nohno, S. Nishimatsu, N. Katase, K. Terada, M. Katsuyama, M. Demura, K. Saijoh, H. Nagatsuka, H. Katsuyama. Kawasaki Medical School, Japan, Okayama University, Japan and Kanazawa University, Japan. B100 757.4 Non-Coding RNA Editing Involved in Adipose Dysfunction During Aging. A. Seidler, A. Marcelo, J. Page, N. Santanam. Marshall University, Marshall University School of Medicine and Cheyney University. B101 757.5 “Listening In”—The Cross-Talk Between Mother and Infant Through Exosomal microRNAs in Breast Milk. J.D. Kraft, I. Altosaar. University of Ottawa, Canada. B102 757.6 Functional Characterization of DiabetesInduced Long Non-Coding RNA Dnm3os in Macrophages. S.C. Das, M.A. Reddy, P. Senapati, M. Wang, L. Lanting, H. Oh, S. Devaraj, R. Natarajan. City of Hope, Texas Children’s Hospital and Houston. B103 757.7 Developing a Method to Identify and Study the Transcriptome of miRNAs Important in Myogenesis. G. Salant, J. Goodrich, J. Kugel. University of Colorado and Boulder.
B104 757.8 Role of Long Non-Coding RNA Alive in Response to Angiotensin Ii in Vascular Smooth Muscle Cells. V. Amaram, S. Das, A. Leung, A. Reddy, L. Lanting, R. Natarajan. City of Hope. B105 757.9 Regena/NOT2 Is Essential for Gene Silencing by microRNAs. T. Zbornik, K. Andersen, S. Bowden, C. Reinke. Linfield College. B106 757.10 A Novel Long Non-Coding RNA Modulates Macrophage Phenotype During Diet-Induced Obesity. K. Stapleton, Z. Chen, M. Reddy, L. Lanting, A. Leung, J. Dieuliis, R. Natarajan. City of Hope and University of Maryland. B107 757.11 The Neuroprotective Role of miR-1017, a 3′ Tailed Mirtron. M. de Cruz, A. Flynt. University of Southern Mississippi. B108 757.12 Haematological and miRNAs (let-7g, miR-21, miR-141) Expression Modulation Profile in Serum Samples of Human Prostate Cancer. A.B. James, A.O. Fadaka, O.A. Magbagbeola, A. Oturu, O.O. Kolawole, A. Ogunijimi, T. Oshodi, M. Habeebu, F.O. Onawoga, E.O. Ajogbeje. University of Lagos, Nigeria, and Afe Babalola University/ University of Lagos, Nigeria. B109 757.13 Cyclosporin A Alters Expression of Renal MicroRNAs: New Insights into Calcineurin Inhibitor Nephrotoxicity. Y. Bai, C. King, C. Francis, J. Gooch. Philadelphia College of Osteopathic Medicine and Emory University. B110 757.14 Transcriptome-Wide Mapping of the miR-122 Targetome Revealed Its Mechanistic Role in the Maintenance of Liver Homeostasis. J.M. Barajas, J. Luna, K. Teng, R. Darnell, K. Ghoshal. The Ohio State University and The Rockefeller University. B111 757.15 New Biotechnology to Inhibit microRNA Activity in Vivo and in Vitro. B. Amendt, H. Cao, W. Yu, T. Sharp, S. Eliason. University of Iowa. B112 757.16 Alteration of miR-186 Expression Modifies Inflammatory Markers in Normal Epithelial and Prostate Cancer Cell Models. S. Suman, D.Z. Jones-Reed, M.L. Schmidt, G.J. Clark, C. Klinge, S. Barve, K.S. Kimbro, L.R. Kidd. University of Louisville and North Carolina Central University. B113 757.17 Investigation of PAX3-FOXO1 Effect on NEAT1 Expression in Alveolar Rhabdomyosarcoma Cells. V.A. George, B. McDaniel, K.E. Johanson. Xavier University of Louisiana. B114 757.18 MicroRNA-506-3p as a Differentiation Agent for Neuroblastoma. M. Sousares, L. Du. Texas State University. B115 757.19 Functional Non-Coding ncRNA in Vascular Epigenetics: Redox Editing and Structural Relations of Factors. J.H. Wissler. ARCONS Institute of Applied Research & Didactics, Germany. B116 757.20 Quantifying Downstream Regulatory Output as a Way to Understand the Biogenesis Pathways of Endogenous siRNAs in C. elegans. L.T. Izzo, E.M. Youngman. Villanova University. B117 757.21 Nonstop Decay in C. elegans: Examination of a Possible Role for Small Noncoding RNAs. E.M. Youngman. Villanova University.
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BIOCHEMISTRY MONDAY
758. PROTEIN CHEMISTRY, SYNTHESIS AND TURNOVER Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B118 758.1 Positive Charge in the n-Region of the Signal Peptide Contributes to Efficient Post-Translational Translocation of Small Secretory Proteins. M. Liu, J. Sun, Y. Xiong, J. Cui, H. Guo. Tianjin Medical University General Hospital, People’s Republic of China, and The University of Michigan. B119 758.2 CEBPD Is an Early Endoplasmic Reticulum Stress Response Gene Implicated in Breast Cancer Cell Survival. N. Sheshadri, S. Sharan, E. Sterneck. National Cancer Institute. B120 758.3 A Bifunctional Fusion Enzyme with DNA Polymerase and dUTPase Activities. A.K. Dash, S. Bhamidipati, M.B. Rashid. University of Houston-Clear Lake. B121 758.4 The Molecular Basis of Rapid and Selective Diffusion in the Nuclear Pore Complex. S. Sparks, R. Hayama, M.P. Rout, D. Cowburn. Albert Einstein College of Medicine and Rockefeller University. B122 758.5 Llama Hemoglobin Binding to Heterologous Haptoglobins. O.A. Vanderpuye, K. Troutman, N. Kellam, C. Dunn. Albany State University.
759. BIOCHEMISTRY AND BIOPHYSICS OF PROTEINS AND TRANSLATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B123 759.1 Extra-Ribosomal Function of Bacterial Ribosomes: Modulation of Enzyme Activities. A. Shekhtman, C. DeMott, S. Majumder, S. Reverdatto. University at Albany and State University of New York. B124 759.2 In Vivo and in Vitro Studies of RRF (Ribosome Recycling Factor) Revealed That Its Major Function Is to Release mRNA from the Post-Termination Complex and Not Splitting of the Ribosomal Subunits. F. Quaglia, H. Kaji, A. Kaji, Y. Inokuchi. Thomas Jefferson University, University of Pennsylvania and Teikyo University, Japan.
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B125 759.3 Assembly and Disassembly of the Hibernating Bacterial 100S Ribosome. A. Basu. Saint Louis University. B126 759.4 The Cellular Demand for Protein Synthesis Influences the Ribosome Maintenance Program in Vivo. J.C. Price. Brigham Young University. B127 759.5 Differential tRNAser Expression Regulates Translation Rate of a Biofilm Master Regulator During Bacillus subtilis Biofilm Development. G. Di Cecco, J. Greenwich, Y. Chai. Northeastern University. B128 759.6 A Non-Canonical Function of Leucyl tRNA Synthetase Negatively Regulates Skeletal Myogenesis. K. Son, N. Khanna, A. Banerjee, S. Martinis, J. Chen. University of Illinois at Urbana-Champaign. B129 759.7 Translational Regulation of Gene Expression in Mycobacterium: A Means for Coordinating the Expression of Functionally Related Proteins. M.E. Saks, J. Oh, A.C. Deets, G.M. Mastorakos, S.A. Martinis. University of Illinois.
760. PROTEIN INTERACTIONS AND BINDING (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Interactions and Binding (I), Sunday Protein Interactions and Binding (III), Tuesday B130 760.1 Deconstructing the Peptide Specificity of TCR Recognition. T.P. Riley, J. Mendoza, L. Hellman, K. Garcia, B. Baker. University of Notre Dame and Stanford School of Medicine. B131 760.2 Native Proteomics: A New Approach to Protein Complex Discovery and Characterization. P.D. Compton, O. Skinner, N. Haverland, L. Fornelli, P. Doubleday, H. Seckler, L. Schachner, N. Kelleher. Northwestern University. B132 760.3 Expression, Purification and Initial Characterization of the Coiled-Coil 2-3 Region of Atg11, a Central Organizer of Selective Autophagy Initiation. C. Zois, B. Kennedy, S.K. Backues. Eastern Michigan University. B133 760.4 Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Y. Lin. University of Texas Southwestern Medical Center. B134 760.5 Identification of Different Binding Partners of the F-BAR Proteins Cdc42 Interacting Protein 4 (CIP4) and Formin Binding Protein 17 (FBP17) in Cortical Neurons. M.E. McDermott, R.J. Taylor, K.L. Taylor, E.W. Dent. University of Wisconsin-Madison, University of Wisconsin School of Medicine and Public Health, University of Wisconsin School of Medicine and Public Health Madison and Neuroscience.
MONDAY BIOCHEMISTRY B135 760.6 Characterization of ppGpp-Binding Proteins in Escherichia coli. D.T. Nguyen, C.H. Jung. Chonnam National University, Republic of Korea. B136 760.7 Lactoferrin Interacts with SPLUNC1 to Amelioate Lipopolysaccharide-Induced Inflammation of Human Nasal Epithelial Cells. C. Chen, Y. Tsou, H. Chen. National Chung Hsing University, Taiwan and Da-Yeh University, Taiwan. B137 760.8 Affinity and Structural Characterization of Human AT Hook Motif Variants. K. Dobbins, K.L. Buchmueller. Furman University. B138 760.9 Analysis of Complex Interactions Between the Essential Subunits, Pam16, Tim44, and Tim50, of the Hsp70Based Mitochondrial Protein Import Machinery. N.L. Yan, S. Ting, B. Schilke, E.A. Craig. University of Wisconsin. B139 760.10 Examining How Allosteric Mutations Affect Ligand Binding and Specificity on Dihydrofolate Reductase. M. Alfonso, M. Okondo, N.M. Goodey. Montclair State University. B140 760.11 Novel Bryostatin-1 Targets: Mammalian Unc13-1 and Unc13-2 Isoforms. F.A. Blanco, S. Pany, A.A. Ghosh, Y. You, J. Das. University of Houston. B141 760.12 Carboxyl-Terminus of TFG Regulates Directional Movement of COPII Transport Carriers. S. Block, M. Hanna, A. Audhya. University of Wisconsin-Madison. B142 760.13 Probing the Pal-Peptidoglycan Interaction. S. Phadke, S. Stanton, J. Pierce, C. LaClair, C. Hall, L. Michel. Rochester Institute of Technology. B143 760.14 The Role of a Flexible Loop in Metal Transfer Between Periplasmic Zinc Proteins. S.H. Fullam. New Mexico State University. B144 760.15 Determining Histone Deacetylase 8 Substrates Using Non-Natural Amino Acids. J. Lopez, S. Haynes, J. Majmudar, B. Martin, C. Fierke. University of Michigan. B145 760.16 Endocytosis of Phosphorothioate Antisense Oligonucleotides (ASO) by the Stabilin Receptors. A. Egger, B. Kellar, C.M. Miller, E.N. Harris. University of Nebraska-Lincoln. B146 760.17 Identifying Serine Proteases Involved in HMPV F Cleavage. J.T. Kinder. University of Kentucky. B147 760.18 Molecular Mechanisms Associated with Early Onset Primary Dystonia (DYT16) Caused by Mutations in PACT. S.B. Burnett, L. Vaughn, R. Patel. University of South Carolina. B148 760.19 Determination of DNA Binding Interactions for Individual Constructs of the PICKLE Protein’s DNA Binding Domain in Arabidopsis thaliana. K.J. Ernzen, K.K. Ho, J. Ogas. Viterbo University and Purdue University. B149 760.20 Cellular Protein P32/gC1qR Recruits PKC to Viral Protein ICP34.5 and Facilitates HSV Nuclear Egress. C. Zhang, S. Wu, Y. Wang, L. Zhang, S. Pan, Y. Liu, M. Yang, D. Chen, J. Wang, B. He, Y. Cao. Nankai University, People’s Republic of China, and University of Illinois. B150 760.21 Generation of TYRO3 Receptor Tyrosine Kinase Clones to Study Interactions with SH2 Domain Proteins in the Retinal Pigment Epithelium. L. Harris, S. Shelby. Florida Southern College. B151 760.22 Multiple Approach to Determine Protein-Protein Binding Affinity of Calcineurin Homologous Protein Isoforms 1 and 2 and the Sodium Hydrogen Exchanger Isoform 1. C.N. Marshall, M.A. Wallert, M.A. Wallert, J.J. Provost. University of San Diego and Bemidji State University.
B152 760.23 Bacteriophytochromes in Myxobacteria: Implications for Light-Control of Cell Development. G.C. Tracy, K.D. Gallagher, J.D. Varela, D. Bizhga, P. Duong, A. Nugent, E.A. Stojkovic. Northeastern Illinois University. B153 760.24 BECN Homologs and ATG14 Form a Metastable Coiled-Coil to Mediate Autophagy. S. Sinha, M. Su, Y. Li, B. Levine, C. Colbert. North Dakota State University, Howard Hughes Medical Research Institute and University of Texas Southwestern Medical Center.
761. PROTEIN STRUCTURE AND BIOPHYSICS (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B154 761.1 Detecting Lipid Induced Structural Changes of Marburg Virus-VP40 Protein Using Hydrogen-Deuterium Exchange Mass Spectroscopy (HDX-MS). K.J. Wijesinghe, S. Urata, S. Li, R.V. Stahelin. University of Notre Dame, University of California-San Diego and Indiana University School of Medicine-South Bend. B155 761.2 Destabilization of the Non-Polar Subdomain of Hemolysin A Inhibits Hemolysis. M.R. Brunner, D. Grilley, T.M. Weaver. University of Wisconsin La Crosse. B156 761.3 Testing c-Type Heme Sources for Nontypeable Haemophilus influenzae. S. Stanton, J. Pierce, V. Sgheiza, K.L. Bren, L. Michel. Rochester Institute of Technology and University of Rochester. B157 761.4 Probing the Role of Allostery in Rho and Ras GTPases. K. Marcus, B. Ma, R. Nussinov, C. Mattos. Northeastern University and National Cancer Institute. B158 761.5 Characterizing the Interactions Between Mg2+ and a Periplasmic Lipoprotein Involved in Mg2+ Homeostasis in Salmonella enterica. T.J. Davie, J.F. May. University of Wisconsin-La Crosse. B159 761.6 Structural and Functional Insights into σ1 Receptor Ligand Binding. H.R. Schmidt, A.C. Kruse. Harvard Medical School. B160 761.7 Purification and Structural Analysis of an Uncharacterized Lytic Protein in Epstein-Barr Virus. M.D. Scheidt, K. Gorres. University of Wisconsin—La Crosse. B161 761.8 Characterization of the Ordered Domain of an Epstein Barr Viral Tegument Protein. M.E. Marlowe, K. Gorres. University of Wisconsin-La Crosse. B162 761.9 Structural Characterization of a Periplasmic Lipoprotein Associated with Magnesium Homeostasis in Salmonella enterica. D.M. Rasmussen, C. Varneerd, B. Bhattacharyya, J. May. University of Wisconsin- La Crosse. B163 761.10 Using Biophysical Characterization to Explore Suppressor of IKKepsilon Structure. M.L. Machek, F. Shikwana, S.I. Graham, I.D. Minzer, R. Wey, R. Cruz, E. Bell, J.K. Bell. University of San Diego and Westview High School.
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BIOCHEMISTRY MONDAY B164 761.11 Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation. J.F. May, D.M. Rasmussen, T.J. Davie, C. Vaneerd, E.A. Groisman, B. Bhattacharyya. University of Wisconsin-La Crosse, Yale School of Medicine and Yale Microbial Sciences Institute. B165 761.12 Structure and Stability of C19orf10 as Assessed by Circular Dichroism. V. Bortnov, D.S. Annis, D.R. McCaslin, D.F. Mosher. University of Wisconsin. B166 761.13 Evaluating the Role of Corynebacterium matruchotti MdAa in Oral Biofilm Formation. R. Tirgar, T.T. Luong, H. Ton-That. University of Saint Thomas and The University of Texas Health Science Center at HoustonMcGovern Medical School. B167 761.14 Evolutionary Fine-Tuning of Conformational Ensembles in Fimh During Host-Pathogen Interactions. V. Kalas, J.S. Pinkner, T.J. Hannan, M.E. Hibbing, J.W. Janetka, S.J. Hultgren. Washington University in St. Louis. B168 761.15 Thermodynamic Partitioning Forces at the Membrane Protein Interface. R. Mahalakshmi. Indian Institute of Science Education and Research, India. B169 761.16 Pinpointing the Divergence of Quaternary Structure in the Lysine Biosynthetic Pathway. G. Pearce, S. Watkin, J. Keown. University of Canterbury, New Zealand and University of Auckland, New Zealand. B170 761.17 Molecular Insights Into the Structural Stability and Biological Activity of T4 Bacteriophage DNA Polymerase Processivity Factor. V. Jain, M.I. Singh. IISER Bhopal, India. B171 761.18 Toward the Structure of PE5-PPE4-EspG3 Heterotrimer from Mycobacterium smegmatis to Elucidate PEPPE Dimer Recognition by Cognate EspG. Z. Williamson, W. Ciocca, R. Reed, K. Korotkov. University of Kentucky and Eastern Kentucky University. B172 761.19 An Automated Method for the Correction of Unsubstantiated Ramachandran Outliers in Protein Structures. C.R. Smith, J.A. Alaniz, K.H. West, C.J. Weiss, W.R. Novak. Wabash College. B173 761.20 Structural and Functional Characterization of an F17-Like CUP Adhesin from Uropathogenic E. coli Isolate UTI89. R.D. Klein, C. Spaulding, S. Hultgren. Washington University in St. Louis School of Medicine. B174 761.21 Complex Structure of the Disulfide BondDimerized PDZ-RhoGEF and CXCR2 PDZ-Binding Motif: A New Mode of PDZ Dimerization. N.S. Spellmon, J. Holcomb, A. Niu, V. Choudhary, J. Brunzelle, C. Li, Z. Yang. Wayne State University, Life Sciences Collaborative Access Team and Georgia State University. B175 761.22 Characterization of the Role for the N-Terminal Domain on Sil1 Activities as a Nucleotide Exchange Factor and Reductase. K.A. Pareja, C. Sevier. Cornell University. B176 761.23 An Alternative Structural Model of Activation for the Anti-Anti-σ Factor PhyR and Interaction with the Anti-σ Factor NepR. J.L. Luebke, D.S. Eaton, J.R. Sachleben, S. Crosson. University of Chicago. B177 761.24 Developing Monovalent Ion Parameters for the Optimal Point Charge (OPC) Water Model. D.E. Clark, J.C. Dood, B.P. Krueger. Hope College. B178 761.25 Cooperative Binding of Cinnamon Polyphenols as Activators of Sirtuin-1 Protein in the Insulin Signaling Pathway. M. Brennemen, T. Mahfouz, A. Stockert. Ohio Northern University.
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B179 761.26 The Conformation of Apolipoprotein E4 on Discoidal and Spherical High Density Lipoproteins Using Chemical Crosslinking and Fluorescence Spectroscopy. N. Bala, K. Taiwo, V. Narayanaswami. California State University at Long Beach. B180 761.27 Correlation of Fitness Landscapes from Three Orthologous TIM Barrels Originates from Sequence and Structure Constraints. Y.H. Chan, S.V. Venev, K.B. Zeldovich, C.R. Matthews. UMass Medical School.
762. PROTEIN DYNAMICS AND FLUCTUATIONS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B181 762.1 A Discrete SERCA N-Domain Loop Plays a Role in Pump Structural Dynamics and Functional Regulation. O.N. Raguimova, N. Smolin, E. Bovo, A.V. Zima, S.L. Robia. Loyola University Chicago. B182 762.2 Salt-Dependent Protein Splicing in Extreme Halophiles. C.J. Janton, J.N. Reitter, K.V. Mills. College of the Holy Cross. B183 762.3 Stress-Triggered Self-Association of an Enzyme Reverses Its Catalytic Activity. H. Yoo, R. Goyal, D. Drummond. University of Chicago. B184 762.4 NMR Studies of Ubc9 Mutant Identify Structural Basis for SUMO Target Selection. W.J. Placzek, M. Bjornsti, R.H. Whitaker, C. Wright, J. Onuiri. The University of Alabama at Birmingham. B185 762.5 Altered Protein Dynamics Modified the Chemical Step in Thymidylate Synthase. A.K. Ghosh, T. Abeysinghe, A. Kohen. The University of Iowa. B186 762.6 Conformational Motions Impacting Function in an Enzyme Superfamily. C. Narayanan, D.N. Bernard, K. Bafna, O.P. Choudhary, C.S. Chennubhotla, P.K. Agarwal, N. Doucet. INRS—University of Quebec, Canada, University of Knoxville. B187 762.7 Modeling Dynamics in the D-Amino Acid Oxidase Protein. L. Kueffer, W. Beyers. University of Wisconsin—Stevens Point. B188 762.8 The Effects of Nucleotides on the Conformational Flexibility and Stability of Glutamate Dehydrogenase. S. Tran, J.K. Bell, E. Bell. University of San Diego. B189 762.9 Dynamics Underlying Cytochrome P450cam Regioselectivity via 2D IR Spectroscopy. M. Thielges, E. Basom. Indiana University and Indiana Univeristy. B190 762.10 Conformational Changes in Palladin ActinBinding Domains Measured by Fluorescent Resonance Energy Transfer. S. Womack, R. Vattepu, M.R. Beck. Wichita State University. B191 762.11 Structure, Dynamics and Folding of an Immunoglobulin-Like Domain of Actin Binding Protein Palladin. R. Vattepu, M.R. Beck. Wichita State University.
MONDAY BIOCHEMISTRY
763. PROTEIN MISFOLDING AND AGGREGATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B192 763.1 ATF6 Activation Remodels the Endoplasmic Reticulum Proteostasis Network to Restore Proteostasis of Pathogenic GABAA Receptors. Y. Fu. Case Western Reserve University. B193 763.2 Characterization of Anti-SOD1 Antibodies and Detection of Intermediary SOD1 Oligomers. R.S. Atlasi, R. Malik, C. Corrales, L. Tzeplaeff, N. Cashman, G. Bitan. University of California, Los Angeles (UCLA), Strasbourg University, France and University of British Columbia (UBC), Canada. B194 763.3 Engineering Hsp104 Variants to Counter Protein Misfolding. M. Jackrel, J. Shorter. University of Pennsylvania. B195 763.4 Copper-Zinc Superoxide Dismutase as a Convenient System for Assessment of Safety Margins in Vitro. R. Malik, C. Corrales, R.S. Atlasi, J.S. Valentine, T. Schrader, F. Klärner, G. Bitan. UCLA and Duisburg-Essen University, Germany. B196 763.5 Investigation of Cellular Signaling and Epigenetic Dynamics via Optogenetic Control of Nuclear Cytoplasmic Distribution. H. Yumerefendi, B. Kuhlman. University of North Carolina at Chapel Hill. B197 763.6 Role of Folding Intermediates in Initiating Aggregation of the Prion Protein. R. Moulick, R. Goluguri, J.B. Udgaonkar. NCBS and IFR, India. B198 763.7 Protein Aggregation in Ehrlichia chaffeensis During Infection of Mammalian Cells. M. Zolkiewski, D. Kuczynska-Wisnik, C. Cheng, R.R. Ganta. Kansas State University, University of Gdansk, Poland and Vanderbilt University Medical Center. B199 763.8 A Common Mechanism of Proteasome Impairment by Neurodegenerative Disease-Associated Oligomers. T.A. Thibaudeau, R. Anderson, D.M. Smith. West Virginia University and School of Medicine. B200 763.9 Host vs Virus: HSV Has Evolved to Evade Host Antiviral Mechanisms by Manipulating the Host Proteostasis Machinery. S. Weller, M. Adlakha. University of Connecticut School of Medicine. B201 763.10 Translation of Heat Shock Proteins Is Regulated by Poly(A)-Binding Protein Assembly. C.D. Katanski, J. Riback, E. Pilipenko, D.A. Drummond. University of Chicago. B202 763.11 Identifying and Ameliorating Complex Collagen Misfolding Defects. M.D. Shoulders. Massachusetts Institute of Technology. B203 763.12 Propagation of Tau Prions from Alzheimer’s Disease and Chronic Traumatic Encephalopathy Patients in Cultured Cells. A.L. Woerman, A. Aoyagi, S. Patel, S.A. Kazmi, I. Lobach, L.T. Grinberg, A.C. McKee, W.W. Seeley, S.H. Olson, S.B. Prusiner. University of California San Francisco, Daiichi Sankyo Co., Ltd. and Boston University. B204 763.13 Protein Aggregation Small Molecule Inhibitor Discovery and Mechanisms. B. Xu. Virginia Tech.
B205 763.14 Tau and α-Synuclein Protein Expression, Purification, and Their Amyloid Inhibitor Discovery. M. Marcus, F. Henderson, K. Kelly, A. Umana, P. Velander, L. Wu, B. Xu. Virginia Tech. B206 763.15 Metal Induced Conformational Changes of Alpha-Synuclein and the Role of Ambient Oxygen. H.R. Lucas. Virginia Commonwealth University.
764. ENZYME MECHANISMS, KINETICS AND ENERGETICS (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Enzyme Mechanisms, Kinetics and Energetics (I), Sunday B207 764.1 Effects of Isotopic Substitution in Enzyme and Co-Factor on Enzyme Catalyzed Hydride Transfer. C. Ranasinghe, P. Pagano, Q. Guo, C. Cheatum, A. Kohen. The University of Iowa. B208 764.2 Reactivity of Neuroglobin with H2S. M. Ruetz, J. Kumutima, M. Filipovic, N. Lehnert, R. Banerjee. University of Michigan and University of Bordeaux, France. B209 764.3 Spectroscopic Insight Into the Mechanism of Nickel-Substituted Rubredoxin, a Bioinspired Hydrogenase Mimic. M.J. Stevenson, J.W. Slater, S.C. Marguet, H.S. Shafaat. The Ohio State University. B210 764.4 Investigation of the Substrate Specificity of L-Idonate Dehydrogenase by Site-Directed Mutagenesis. S. Steiner, A. Terpening, C. McCurdy. Hanover College and Indiana University School of Medicine. B211 764.5 Temperature and Pressure Dependence of the Activity of Inteins from Extreme Thermophiles. H.Y. Comeau, J.D. Long, I.V. Pierre, J.N. Reitter, K.V. Mills. College of the Holy Cross. B212 764.6 Insights into Radical SAM Enzyme Mechanism from Lysine-2,3-Aminomutase and an S-Adenosyl-L-Methionine Analog. A. Byer, J. Broderick. Montana State University. B213 764.7 Expression, Purification, and Characterization of Codon Optimized and Mutant Variations of DszB from N. asteroides. J.J. Gumpf, K. Idrizi, L. Watkins. James Madison University. B214 764.8 Substrate Specificity of the Novel Serine Hydrolase, LipN, Implicated in the Virulence of Mycobacterium tuberculosis. D. Schemenauer, R. Johnson. Butler University. B215 764.9 Elucidating the Mechanism of Thiol Oxidase Activity of a B12-Trafficking Protein. Z. Li, A. Shanmuganathan, M. Ruetz, N. Lesniak, M. Koutmos, R. Banerjee. University of Michigan and Uniformed Services University of the Health Sciences. B216 764.10 Specificity Studies of the Aromatic Desulfinase, 2-(2′-Hydroxyphenyl)Benzenesulfinate Desulfinase (DszB) from Nocardia asteroides A3H1. D.M. Hoang, E. Smith, L. Watkins. James Madison University.
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BIOCHEMISTRY MONDAY B217 764.11 Evaluating the Catalytic Role of a Conserved Glutamate Residue in Triosephosphate Isomerase from Trypanosoma brucei brucei. C.B. Khoury, N. Seangmany, T.C. Chang, J.P. Schwans. California State University at Long Beach. B218 764.12 Investigating Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors. J.P. Schwans, J. Gonzalez, T. Tran, J. Ochoa, K. Nakayama, S. McCoy, E.J. Sorin. California State University at Long Beach. B219 764.13 Sulfide Oxidation and Transfer Catalyzed by a Bacterial Persulfide Dioxygenase Fused to a Rhodanese. N. Motl, O. Kabil, M. Skiba, J. Smith, R. Banerjee. University of Michigan. B220 764.14 Balance of Conformational States Affect the Intrinsic Hydrolysis of NRas When Compared to Other Ras Isoforms. D.F. Reid, C. Mattos. Northeastern University. B221 764.15 Factors That Influence Recombinant Lysine Deacetylase Activity. S.A. Imbraguglio, B.J. Hylton, T.B. Toro, T.J. Watt. Xavier University of Louisiana. B222 764.16 Optimization of the Paired Enzyme Assay Synthesizing UDP-Xylose from UDP-Glucose. M.D. Cook, A. Culbertson, O. Zabotina. Iowa State University. B223 764.17 Development of a Thermostable ATP Hydrolysis Coupled Enzyme Activity Assay. K.L. Cumpian, M.D. Canny, M.P. Latham. Texas Tech University. B224 764.18 Unmasking the High Affinity of Escherichia coli Glycogen Synthase Toward Its Polyglucan Substrate. A.A. Iglesias, M. Aleanzi, M.D. Asencion Diez, M. Machtey, A. Yep, M. Ballicora. Instituto de Agrobiotecnologia del Litoral, Argentina, Cal Poly and Loyola University at Chicago.
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765. ENZYME REGULATION AND ALLOSTERISM Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B225 765.1 Manipulating Cellular Adaptive Response by Engineering Novel and Evolutionarily Conserved Allosteric Sites in Caspase-3. M.E. Thomas III, C. Clark. NCSU and UTA. B226 765.2 Resurrection of Caspase-6 Ancestral States. R.D. Grinshpon, A.C. Clark. NCSU and UT—Arlington. B227 765.3 Designing Highly Specific ProteinBased Small Molecule Biosensors. S. Raman. University of Wisconsin-Madison. B228 765.4 Allosteric Regulation and Enzymatic Mechanism of YopJ Family of Bacterial Effectors. J. Song, Z. Zhang, K. Ma, L. Gao, W. Ma. University of California at Riverside. B229 765.5 Delving Into the Details: Investigation of the Kinetic Properties of SpeG Spermidine N-Acetyltransferases from Escherichia coli and Vibrio cholerae. M.L. Kuhn, J. Dang, W. Hong, E. Jung, D. Tran, D. Asaro, K. Jew. San Francisco State University. B230 765.6 Modulation of Sirtuin NAD+-Dependent Deacylase Activity by Cysteine Oxidation. K.S. Kalous, S.L. Wynia-Smith, M.D. Olp, B.C. Smith. Medical College of Wisconsin. B231 765.7 Phosphoinositides and Kinesin 13 Family Member Kif2A Cooperatively Regulate Arf GTPase Activating Protein AGAP1. N.S. Roy, R. Luo, P.A. Randazzo. National Cancer Institute and National Institutes of Health. B232 765.8 A Potential Modification of the Production of the Essential Amino Acid: L-Threonine. C. Petit, Y. Kim, S. Lee, C. Kang, D. Ronning. University of Toledo and California State University-Stanislaus. B233 765.9 Phospholipase A2: A Unique Paradigm of Allosteric Regulation by Membranes. V. Mouchlis, J. McCammon, E. Dennis. UC San Diego. B234 765.10 The Predicted Human PANK4 Lacks Key Catalytic Residues for Pantothenate Kinase Function. J. Yao, C.O. Rock, S. Jackowski. St Jude Children’s Research Hospital.
MONDAY BIOCHEMISTRY B235 765.11 Redox Control of PRMT1 Substrate Specificity. T.B. Caceres, O. Price, Y. Morales, J. Hevel. Utah State University. B236 765.12 Structural Insight Into Allosteric Inhibition of Mycobacterium tuberculosis Tryptophan Synthase. K. Michalska, S. Wellington, P.P. Nag, R. Jedrzejczak, N.I. Maltseva, S.L. Fisher, S.L. Schreiber, D.T. Hung, A. Joachimiak. University of Chicago, Broad Institute of MIT and Harvard, Harvard Medical School, Massachusetts General Hospital and Harvard University. B237 765.13 Physiological Significance of Persulfide Generation by The Transsulfuration Pathway. P.K. Yadav, M. Martinov, V. Vitvitsky, J. Seravalli, R. Wedmann, M.R. Filipovic, R. Banerjee. University of Michigan, Russian Academy of Sciences, Russian Federation, University of Nebraska-Lincoln and Friedrich-Alexander University of Erlangen-Nuremberg, Germany. B238 765.14 The Firmicutes Case on the Regulation of Bacterial ADP-Glucose Pyrophosphorylase. M.D. Asencion Diez, A.E. Cereijo, A. Demonte, M. Ballicora, A.A. Iglesias. Instituto de Agrobiotecnologia del Litoral, Argentina and Loyola University at Chicago. B239 765.15 The Regulatory Subunit Type Iα of Protein Kinase A: A Study of Carney Complex and Acrodysostosis Mutations. J.C. Del Rio, C.R. Nielsen, S.S. Taylor. UC San Diego. B240 765.16 Negative Allosteric Regulation of a Serine Hydrolase by Divalent Metal Cations. G.C. Hoops. Butler University. B241 765.17 Role of the Inter-Subunit Surface Interaction in the Regulation of the ADP-Glucose Pyrophosphorylase from Agrobacterium tumefaciens. H.P. Patel, E. Dobrzynski, D. Liu, M.A. Ballicora. Loyola University of Chicago. B242 765.18 Divergent Mechanisms of Allosteric Regulation of Pyruvate Carboxylase by Acetyl Coenzyme A. Y. Liu, M. St.Maurice. Marquette Univerisity. B243 765.19 Probing the Role of N- and C-Terminal Regions in Allosteric Regulation of Thermodesulfovibrio yellowstonii ADP-Glucose Pyrophosphorylase. E. Yik, S. Kaur, E. Pushkarev, E. Mercado, M. Collazo, D. Cascio, H. Axelrod, C.R. Meyer. California State University, Fullerton and UCLA. B244 765.20 Structure/Function Studies of Diverse Forms of ADPGlucose Pyrophosphorylase. C.R. Meyer, L. Ong, C. Vu, H. Axelrod, A. Orry. California State University, Fullerton and MolSoft LLC.
766. CHEMICAL BIOLOGY OF NATURAL PRODUCTS AND SMALL MOLECULES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B245 766.1 Identification of Tumor Necrosis Factor-α Inhibitors from the Traditionally Used Chinese Plant Mappianthus iodoides. M. Garrison, H. Park, M. Wright, A. Farone. Middle Tennessee State University. B246 766.2 Biosynthetic Studies of the Antibiotic Uncialamycin. H. Hindra, T. Huang, D. Yang, X. Yan, H. Ge, B. Shen. The Scripps Research Institute. B247 766.3 Mechanisms by Which Plant Extracts Delay Aging in Yeast by Targeting Certain Signaling Pathways and Modulating Lipid Metabolism. V. Titorenko, V. Lutchman, Y. Medkour, A. Arlia-Ciommo, P. Dakik, M. McAuley. Concordia University, Canada. B248 766.4 Distracting the Hungry: Mosquito AnosmiaInducing and Odor Perception-Enhancing Compounds of Natural Origin Targeting ORco Function for Control of Transmission of Malaria and Other Mosquito-Borne Infectious Diseases. K. Iatrou, P. Tsitoura, M. Konstantopoulou. National Centre for Scientific Research “Demokritos”, Greece. B249 766.5 The Effects of Silibinin on Colorectal Cancer Cell Line. M.A. Horita, U. Ezekiel. Saint Louis University. B250 766.6 High-Throughput Natural Products Discovery in Fungi Using FAC-MS Technology. K.D. Clevenger, J.W. Bok, R. Ye, G.P. Miley, M.H. Verdan, T. Velk, C. Chen, K. Yang, P. Gao, M. Robey, M. Lamprecht, P.M. Thomas, M.N. Islam, J. Palmer, C.C. Wu, N.P. Keller, N.L. Kelleher. Northwestern University, University of Wisconsin at Madison, Intact Genomics, Inc and US Forest Service. B251 766.7 Annona senegalensis Shows Potent AntiDiabetic Activity by Attenuating DNA Fragmentation in Oxidative Injury and Inhibiting Key-Enzymes Linked to Type 2 Diabetes. O.L. Erukainure, S. Islam. University of KwaZuluNatal, South Africa. B252 766.8 Deciphering the Function of NTF2-Like Proteins Associated with Polyketide Biosynthesis in Actinomycetes. N. Vuksanovic, X. Zhu, N.R. Silvaggi, C.E. Melançon III. University of Wisconsin-Milwaukee and University of New Mexico. B253 766.9 Abscisic Acid/Dormin, a Plant Hormone That Inhibits Angiogenesis in Vitro and Neovascular Growth in Vivo. J.Y. Chaqour, S. Lee, B. Chaqour. High Technology HS and SUNY Downstate Medical Center. B254 766.10 Structure Revision and Biological Evaluation of Artabonatine A and Its Diastereoisomer. A. Ku, G. Cuny. University of Houston.
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BIOCHEMISTRY MONDAY B255 766.11 Relationship in Broccoli Between Genetic Mapping and Small Molecule Profiling Using NMR Spectroscopy. K. Knagge, G. Yousef, J. Winnike, K. Blankenship, A. Thomas, A. Brown. David H Murdock Research Institute, North Carolina State University. B256 766.12 Microarray and Pathway Analysis of Prostate Cancer Tumors Treated with Andrographolide. I.S. ForestierRoman, M. Sánchez, K. Rohena, H. Ortiz-Zuazaga, M. Martínez-Ferrer. University of Puerto Rico Comprehensive Cancer Center, Puerto Rico, University of Puerto Rico Medical Sciences Campus, Puerto Rico, University of Puerto Rico at Rio Piedras, Puerto Rico, School of Pharmacy and University of Puerto Rico Medical Sciences Campus, Puerto Rico. B257 766.13 Effects of Aspirin on Expression of Proteins Implicated in Airway Remodeling in Human Lung Fibroblasts. K. Geary, D. Hasenmeyer, F. Daghigh. Philadelphia College of Osteopathic Medicine, Center for Chronic Disorders of Aging and PCOM. B258 766.14 Evaluation of Anti-Cancer Activity of Simplified Staurosporine Analogs. N. Neerukonda, E.T. Pelky, P. Mowery. Hobart & Wm. Smith Colleges. B259 766.15 New Roles for Dithiolopyrrolones in Disrupting Bacterial Metal Homeostasis and Inhibiting Metalloenzymes. A.N. Chan, A.L. Shiver, W.J. Wever, S.Z. Razvi, M.F. Traxler. University of North Carolina at Chapel Hill, University of California, San Francisco, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Duke University, University of California at Berkeley. B260 766.16 Electrochemical Detection of Isatin Using Flow Injection Analysis with Amperometric Detection. S.W. Sanchez, R. Jarosova, G.M. Swain. St. Mary’s University and Michigan State University. B261 766.17 A Chemical Biology Approach to the Study of Coenzyme Q Biosynthesis and Metabolism. A. Nag, L. Fernandez, J.M. Villalba, J.N. Shepherd, O. Kwon, C.F. Clarke. University of California, Los Angeles, Universidad de Córdoba, Spain and Gonzaga University. B262 766.18 Gene Expression Changes in Polyphenone E-Treated Primary Prostate and Prostate Cancer Cells. L. Carastro, R.A. Cordova, D.E. Barboto, R.A. Declet-Bauzo, I. Gushterova, N.K. Lago, N.E. Braganca, J.C. Burr, D.E. Hoffman, J.Y. Park. University of Tampa, Universidad Central de Caribe and Moffitt Cancer Center & Research Institute. B263 766.19 Characterization of an Unprecedented Hybrid Pteridine-Nonribosomal Peptide Synthetase-Like Biosynthetic Gene Cluster. C.E. Perez, H. Park, K.W. Barber, J. Rinehart, J.M. Crawford. Yale University and Yale School of Medicine. B264 766.20 Predicting Function of Class II Diterpene Cyclases in Bacterial Species Using a Sequence Similarity Network. C. Lemke, R. Nett. Iowa State University.
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B265 766.21 Characterizing the Use of the RNA Mango Aptamer for RNA Pull-Downs and Single Molecule Fluorescence. H.M. Poe, C. van der Feltz, X. Chen, P. Unrau, A. Hoskins. University of Wisconsin—Madison and Simon Fraser University, Canada. B266 766.22 Predicting and Interpreting the Hofmeister Effects of Different Salts with Nucleic Bases and Aromatic Compounds Using Solubility Assay. R. Hong, L. Cheng, Y. Yao, B. Knowles, Y. Zhang, M. Kerins, I. Shkel, M. Record. University of Wisconsin Madison. B267 766.23 Second Generation PS-ASO Internalization and Endosomal Escape. C. Miller, A. Egger, B. Kellar, B. Hass, P.P. Seth, E.N. Harris. University of Nebraska-Lincoln and Ionis Pharmaceuticals Inc.
767. CHEMICAL PROBES, BIOSENSORS AND BIOMARKERS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B268 767.1 Probing the Charge and Conformational Requirements of JmjC Demethylases. G.W. Langley, A. Brinkø, M. Münzel, L.J. Walport, C.J. Schofield, R.J. Hopkinson. University of Oxford, United Kingdom and Aarhus University, Denmark. B269 767.2 Development of Algorithmic Techniques for Designing Electrochemical DNA Biosensors. A.J. Bonham, A.J. Bulow. Metropolitan State University of Denver. B270 767.3 Development of Red Fluorescent Protein pH Sensors. M. Rajendran, E. Haynes, B. Claywell, U. Scales, C. Henning, M. Tantama. Purdue University. B271 767.4 Chemoenzymatic Synthesis of Bioorthogonal Peptidoglycan Derivatives: Tools to Remodel Bacterial Cell Wall. Z. Jones. University of Delaware. B272 767.5 An Inexpensive and Effective AptamerBased Evanescent Wave Biosensor. I. Mazin, A.J. Bonham. Metropolitan State University of Denver. B273 767.6 Lanthanide-Based FRET Biosensors for TimeGated Imaging and Detection of Protein-Protein Interactions in Live Mammalian Cells. T. Chen, H. Pham, L. Miller. UIC. B274 767.7 Measuring Oxytocin Hormone and OxytocinReactive Autoantibodies to Determine Their Correlation with the Severity of Clinical Depression. S.E. Thompson, A.J. Russo. Hartwick College.
MONDAY BIOCHEMISTRY B275 767.8 Multiplexing Metabolomic-Based Disease Diagnosis by Surface Enhanced Raman Spectroscopy (SERS) Platform. Y. Chen, L.D. Ziegler. Boston University. B276 767.9 Biosensor Diagnostic for Congestive Heart Failure via Detection of B-Type Natriuretic Peptide. N. Dubchak, A.J. Bonham. Metropolitan State University of Denver. B277 767.10 Serological Diagnosis of Mycoplasma via Lipoprotein Specific Electrochemical Biosensor. J. Jacobs, A.J. Bonham. Metropolitan State University of Denver. B278 767.11 Global Substrate Specificity of Mycobacterial Serine Hydrolases. R. Johnson, B. Bassett, B. Waibel, A. White, H. Hansen, D. Stephens, A. Koelper, G. Hoops. Butler University. B279 767.12 A Novel and Robust Series of Organelle Fluorescent Probes. G. Rigden, C. Tourville, D. Lewis, S. Hartsel. University of Wisconsin-Eau Claire. B280 767.13 ENOX2-Selective Aptamer Identification for an Electrochemical-Aptamer Biosensor in Cancer Diagnostics. L.C. Fetter, J. Jacobs, A.J. Bonham. Metropolitan State University of Denver. B281 767.14 Constructing Red-Shifted Fluorescent Protein Sensors of Cellular Redox Status. S. Norcross, K. Trull, J. Snaider, S. Doan, K. Tat, L. Huang, M. Tantama. Purdue University. B282 767.15 Building a Synthetic Library of Fluorogenic Ester Substrates to Analyze Serine Hydrolases. A. Koelper, R. Johnson, G. Hoops. Butler University. B283 767.16 Development of Ester-Protected Ethambutol Derivatives for Characterization of Mycobacterial Hydrolase Activity. E. Larsen, D. Stephens, R.J. Johnson. Butler University. B284 767.17 Development of an Arsenic Sensitive Bacterial Biosensor and San Diego Soil Testing. A. Magsumbol, M.S. Magee, J.J. Provost. University of San Diego. B285 767.18 Stereoelectronically Stabilized Flurogenic Probes for Esterase-Activated Biomolecule Imaging. H.R. Kilgore, W. Chyan, B. Gold, R.T. Raines. University of Wisconsin- Madison. B286 767.19 Withdrawn. B287 767.20 High Dynamic-Range LRET Biosensors of Rac1. H.T. Pham, T. Chen, L. Miller. University of Illinois at Chicago. B288 767.21 Toward Cell-Permeable, Multi-Fluorophore Protein Labels for Enhanced LRET Imaging. M.H. Soflaee, C. Ivette Rivera Vera, L. Miller. University of Illinois at Chicago.
768. PROTEOMICS (I) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Proteomics (II), Tuesday B289 768.1 Nicotine-Induced Proteome of Arthrobacter nicotinovorans pAO1+. M. Mihasan, C. Babii, C.C. Darie. Alexandru Ioan Cuza University of Iasi, Romania and Clarkson University. B290 768.2 There Are Still Proteins in Rat Urine After 7-Day Starvation. F. Zhang, Y. Yuan, Y. Ni, Y. Gao. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, People’s Republic of China, Beijing Normal University, People’s Republic of China. B291 768.3 Investigation of Induced Obstructive Sleep Apnea (OSA) in Rat Atria Using Mass Spectrometry Based Proteomics. D. Channaveerappa, J. Lux, K.L. Wormwood, M. McLerie, B.K. Panama, C.C. Darie. Clarkson University and Masonic Medical Research Laboratory. B292 768.4 Temporal Quantitative Proteome Analysis Reveals Dynamic Change of Cellular and Secreted Protein Profiles of Clostridium cellulovorans Depending on Carbon Sources. A. Shunsuke, A. Wataru, K. Kouichi, U. Mitsuyoshi. Kyoto University, Japan, Research Fellow of Japan Society for the Promotion of Science, Japan, Kyoto Integrated Science & Technology Bio Analysis Center, Japan, JST and PRESTO, Japan. B293 768.5 Development of a High Throughput Extraction Procedure for Nuclei and Mitrochondria from Rat Tissues. B. Easparro, S. Garrett, J. Atwood. Omni International. B294 768.6 Proteomic Research on the Therapeutic Mechanism of Zhibai Dihuang Granule for Treating Hyperthyroidism Yin-Deficiency Rats. C. Liu, L. Mao, S. Yang, T. Jiang, C. Wang, Z. Chen, H. Tu, Z. Li, J. Li. Zhejiang University, People’s Republic of China. B295 768.7 A High Serum Vanin-1 Phenotype Is Not Unique to Diving Marine Mammals. B.K. Boxall, K. Prager, B.A. Neely, J.O. Lloyd-Smith, F. Gulland, M.G. Janech. College of Charleston, University of California, Los Angeles, National Institute of Standards and Technology, The Marine Mammal Center and Medical University of South Carolina. B296 768.8 Quantifying Protein Dephosphoylation as a Function of Mechanical Sample Disruption Techniques Toward an Optimized Sample Prep Protocol for Phosphoproteomics. S. Garrett, J. Atwood, B. Easparro. Omni International. B297 768.9 Global Proteomics Assay of UbiquitinKnockout Strains of Yeast. A. Hanse, C. Minogue, E. Cooper. Hartwick College.
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BIOCHEMISTRY MONDAY B298 768.10 Effect of Zhibai Dihuang Granule on AntiInflammatory Proteins Associated with Yin Deficiency Heat Syndrome. L. Mao, C. Liu, T. Jiang, C. Wang, Z. Chen, J. Li. Zhejiang University, People’s Republic of China. B299 768.11 Pathogenesis of AMI Revealed by Integrative Global Transcriptomics and Proteomics Analysis. Y. Wang, W. Lin, C. Nugent, S. Gao, Z. Ma, R. Zhu, C. Li, L. Zhu, W. Wang. Beijing University of Chinese Medicine, People’s Republic of China, Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, People’s Republic of China, Digestive Diseases and Nutrition Center, Department of Bioinformatics, School of Life Sciences and Technology, People’s Republic of China, Genome, Environment and Microbiome Community of Excellence, People’s Republic of China. B300 768.12 Screening and Identification of Novel Serum Potential Biomarkers for Pulmonary Tuberculosis by iTRAQ-2D LC-MS/MS. T. Jiang, L. Shi, X. Li, L. Wei, S. Yang, C. Wang, C. Liu, Z. Chen, H. Tu, Z. Li, J. Li. South China University of Technology School of Medicine, People’s Republic of China, Department of Clinical Laboratory, Zhejiang Hospital, People’s Republic of China, Zhejiang Province People’s Hospital, People’s Republic of China, Shaoxing Municipal Hospital, People’s Republic of China, Zhejiang University, People’s Republic of China. B301 768.13 Over-Expression and Association of Serum PPIA, vwf, and FXIIIa with a Systemic Hypercoagulable State in Patients with Pulmonary Tuberculosis. Z. Chen, T. Jiang, L. Wei, X. Li, L. Shi, M. Li, C. Liu, H. Tu, S. Yang, J. Chen, J. Li. Institute of Cell Biology, Zhejiang University, People’s Republic of China, Shaoxing Municipal Hospital, People’s Republic of China, 468 Yan’an Road, Shaoxing, People’s Republic of China, Zhejiang Hospital, People’s Republic of China. B302 768.14 Proteomics Analysis of Tea Tree Oil-Selected Staphylococcus aureus Small Colony Variant. N.J. Torres, S.D. Hartson, J. Rogers, K.A. Abdulhafid, J.E. Gustafson. Oklahoma State University. B303 768.15 Assessment of the Effects of Pollutants in the Great Lakes on the Human Proteome. E. Dupree, B. Crimmins, T. Holsen, J. Pagano, B. Thompson, K. Christensen, M. Raymond, C. Darie. Clarkson University, SUNY Oswego and Wisconsin Department of Health Services.
769. METABOLOMICS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B304 769.1 Alcohol’s Effect on the Metabolome and CCL2. C.W. Berndt, P. Schumann, A. Dunn, J. Bray, J. Lawrence. University of Wisconsin—Stevens Point. B305 769.2 Integrated Metabolomic Studies on Health Effects of Oxidized Tyrosine Administration in Female Mice. Y. Yang, B. Yan, T. Zhang, Y. Gao, Y. Shi, G. Le. The Laboratory of Food Nutrition and Functional Factors, People’s Republic of China.
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B306 769.3 PathQuant: A Bioinformatic Tool to Quantitatively Annotate the Relationship Between Genes and Metabolites Through Metabolic Pathway Mapping. S. TherrienLaperrière, S. Cherkaoui, G. Boucher, T. Consortium, F. Jourdan, G. Lettre, J. Rioux, C. Des Rosiers. Montreal Heart Institute, Canada, University of Montreal, Canada, Institute of Molecular Systems Biology, ETH Zürich, Switzerland, INRA and Toulouse University, France. B307 769.4 High Resolution Mass Spectrometry Coupled with Multivariate Data Analysis Revealing Plasma Lipidomic Alteration in Patients with Colorectal Cancer. P. ‘de Oliveira Carvalho, M.F. Messias, G.C. Mecatti, C.F. Angolini. Sao Francisco University, Brazil and University of Campinas, Brazil. B308 769.5 Effects of PCBs Exposure on Modulation of Bile Acid Profile and Intestinal Microbiota in Mice. S.L. Cheng, D.Z. Fu, X. Li, K. Khayi, H-J. Lehmler, J.Y. Cui. University of Washington and University of Iowa. B309 769.6 Age- And Species-Specific Activation of CAR on Bile Acid Homeostasis in Mice. S.L. Cheng, K. Buckley, D. Rizzolo, B. Buckley, G.L. Guo, J. Cui. University of Washington and Rutgers University.
770. PROTEIN KINASES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B310 770.1 Identifying the Structural Determinants of Negative Cooperativity in Phosphagen Kinases. K.L. Stock, G. Kerwood, D.L. Fraga. College of Wooster. B311 770.2 O-GlcNAcylation of the Human Kinome. X. Liu, G. Han, A. Pandey, G. Hart. Johns Hopkins University. B312 770.3 Calcium Signals Alter the Mobility and Localization of CaMKIIδ in Cardiomyocytes. B.M. Wood, S. Galice, D.M. Bers, J. Bossuyt. UC Davis. B313 770.4 Role of an Abscisic Acid-Activated Protein Kinase in Drought Response in Soybean Revealed by RNASeq. S.K. Sah, G. Popescu, K.R. Reddy, V. Klink, J. Li. Mississippi State University. B314 770.5 Subcellular Localization and Functional Characterization of cAMP-Dependent Protein Kinase A Isoforms: Painting Specificity by Mosaic Brain Mapping. R. Ilouz, V. Lev Ram, M. Ellisman, S. Taylor. UCSD. B315 770.6 AMPK-Related Kinase MPK38/MELK Potentiates p21-Mediated Apoptosis, Cell Cycle Arrest, and Inhibition of Adipocyte Differentiation via Thr55 Phosphorylation. H. Ha, H. Seong, R. Manoharan. Chungbuk National University, Republic of Korea, and University of Madras, India. B316 770.7 Cancer-Related Mutations of ERK3 Promotes Cancer Cell Invasiveness. H. Alsaran, L. Elkhadragy, W. Long. Wright State University.
MONDAY BIOCHEMISTRY B317 770.8 Structural Elucidation of the Binding of the VavSH2 Domain to the EphA2 Cytoplasmic Region. K. Zhang, J. Ma, C.B. Post, C.V. Stauffacher. Purdue University. B318 770.9 A Platform for Delivery of Isoform Selective Inhibitors with in Vivo Efficacy and Safety: Case Study That Revised Prevailing Perspectives on Active Site Targeting and Delivered a Novel Drug Candidate. S.M. Roy, V. Tokars, D.M. Watterson. Northwestern University. B319 770.10 High-Throughput, Fluorescent Analysis of Reactive Oxygen Species in C. elegans After Knockdown of mrck-1. C. Brown, R. Heying, M. Russo, S. Rigoulot, P. Erickson. Salisbury University and Virginia Tech. B320 770.11 Fyn Regulates Cyclic-AMP Dependent Protein Kinase a Binding Interactions. S.A. Barritt, M.E. Weir, B.A. Ballif, P.B. Deming. University of Vermont. B321 770.12 Novel Molecular Interaction Between CyclicAMP Dependent Protein Kinase A Holoenzymes and LaRelated Protein 4. K.T. O’Toole, P.B. Deming. University of Vermont. B322 770.13 Biochemical Study of a Cancer Driver Fusion Protein, DnaJB1-PKA. T. Lu, P. Zhang, M. Cianfrocco, S. Simon, A. Leschziner, S. Taylor. University of California, San Diego, National Cancer Institute, Rockefeller University and UCSD. B323 770.14 Understanding the Effects of Arginine Kinase Gene Deletion on Mitochondrial Volume in Caenorhabditis elegans. M.A. Beal, D. Fraga, K. Timar. College of Wooster. B324 770.15 PKA Subunit Balance Plays a Key Role in Lipolysis. Y. Ji, J. Lee, J. Han, J. Kong, J. Kim. Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Republic of Korea. B325 770.16 Spatial Organization of a cAMP/Ca2+Regulated Signaling Complex: A Solution Structural Small-Angle X-Ray and Neutron Scattering Study of an AKAP79-Scaffolded Complex Containing Type IIbeta PKA and Calcineurin. J.E. Hall, J. Copps, P. Zhang, A. Heck, D. Blumenthal, S. Taylor. UC San Diego, The Scripps Research Institute, Utrecht Institute for Pharmaceutical Sciences, Netherlands and University of Utah. B326 770.17 The Secret Life of Kinases: Insights into Non-Catalytic Functions from Pseudokinases. J.M. Murphy, E.J. Petrie, K. Davies, M.C. Tanzer, A.V. Jacobsen, J.M. Hildebrand, I.S. Lucet, J. Silke, P.E. Czabotar. Walter and Eliza Hall Institute of Medical Research, Australia. B327 770.18 Importance of “Single Turnover Reaction” in Protein Kinase A Signaling. L.G. Ahuja, J. Wu, P. Zhang, S. Taylor. University of California San Diego and National Cancer Institute.
771. PHOSPHATASES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B328 771.1 Insight Into the Mechanism and Structural Basis for Autoinhibition of PTEN by Phosphorylation of Its C-Terminal Tail. D.R. Dempsey, Z. Chen, S. Thomas, D. Hayward, D. Bolduc, P. Cole. Johns Hopkins University. B329 771.2 At the Crossroads Between TYR and SER/THR Signaling: A New Paradigm in the Regulation of PP2A by SRC Kinase. E. Sontag, J. Sontag, R.J. Gomez, A. Hoffman, G. Taleski, M.D. Mazalouskas, S.K. Hanks, I. Frohner, E. Ogris, B.E. Wadzinski. University of Newcastle, Australia, Vanderbilt University School of Medicine and Medical University of Vienna, Austria. B330 771.3 The Phosphatase PRL-3 as a Novel Drug Target in T-Cell Acute Lymphoblastic Leukemia. M. Wei, H. Jing, J. Liu, C. Wang, J. Blackburn. University of Kentucky. B331 771.4 Cyclosporin A-Induced Calcineurin Isoform Specific Matrix Metalloproteinases (MMP2 and MMP9) Expression in Renal Fibroblasts. C.E. Francis, Y. Bai. Philadelphia College of Osteopathic Medicine. B332 771.5 Uncovering Novel Substrates and Functions for the Calcineurin Phosphatase in Human Cells. C.P. Wigington, J. Roy, N.P. Damle, S. Ei Cho, N. Davey, Y. Ivarsson, C. Wong, A. Gingras, M.S. Cyert. Stanford University, University College Dublin, Ireland, Uppsala University, Sweden and University of Toronto, Canada.
772. ION CHANNELS Poster
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Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B333 772.1 STIM1 Interacts with the Voltage Sensor (L-Channel) of L6 Skeletal Muscle Cell Cultures. S. Pitake, R.S. Ochs. St. John’s University. B334 772.2 Transient Receptor Potential Vanilloid 4 (TRPV4) Regulates Fibroblast Differentiation in Vitro and D. farinae-Induced Airway Remodeling in Asthma in Vivo via Modulation of Matrix Synthesis and Matrix Degradation Mechanisms. F.C. Gombedza, V. Kondeti, N. Al-Azzam, C. Thodeti, S. Paruchuri. University of Akron and Northeast Ohio Medical University. B335 772.3 NADPH Oxidase 4 Expression Is Increased Through TRPV4 Channel In D. farinae-Induced Airway Remodeling and TGF-β1-Mediated Fibroblast Differentiation Into Myofibroblasts. N.Z. Al-Azzam, F. Gombedza, M. Snyderman, C. Thodeti, S. Paruchuri. University of Akron and Northeast Ohio Medical School.
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BIOCHEMISTRY MONDAY B336 772.4 Up-Regulation of Atrial and Neuronal Kir3 Activity by Cholesterol. A. Rosenhouse-Dantsker, A.N. Bukiya. University of Illinois at Chicago and The University of Tennessee Health Science Center. B337 772.5 Fluorescence Investigations of the RateLimiting Step in the HCN Ion Channel Deactivation Pathway. K.E. Magee, T.W. Claydon, E.C. Young. Simon Fraser University, Canada. B338 772.6 Identification of TRPP2 Binding Partners in Mice Tissues. C. Ng, Y. Yu. St. John’s University. B339 772.7 Purification and Crystallization of the C-Terminal Interaction Domains of TRPP Ion Channel Proteins. H.R. Martin, Z. ‘Agbaje, Y. Yu. St. John’s University. B340 772.8 Identification of Extracellular Residues Critical to the Epithelial Sodium Channel. T.Y. Dismuke, R. Booth. Texas State University and University of the Incarnate Word. B341 772.9 Identification of Accessory Proteins Impacting the Function of the Epithelial Sodium Channel (ENaC). T. Adewunmi, R. Booth. Texas State University and University of the Incarnate Word. B342 772.10 Disrupted BKCa Channel β1 Subunit Gene Contributes to Vascular Dysfunction in Pulmonary Hypertension. E.A. Barnes, C. Chen, L. Lee, S.L. Barnes, D.N. Cornfield. Stanford University. B343 772.11 5-Flurouracil Disrupts Nuclear Transport During Apoptosis in a Calcium Dependent Manner. J.A. Koper, K. Higby, L. Foltz, K. Resendes. Westminster College. B344 772.12 Piezo1 Mediated Mechanotransduction of Wall Shear Stress Activates Ca2+ Gating Secondary to Src Phosphorylation of Piezo1 and Induces Angiogenesis. H. Kang, M. Mittal, A. Karginov, Y. Komarova, D. Mehta, A. Malik. University of Illinois College of Medicine. B345 772.13 Regulation of the Arabidopsis thaliana Ca2+Dependent Protein Kinase, CPK28, by Autophosphorylation and Calmodulin-Binding. K.W. Bender, R.E. Zielinski, S.C. Huber. University of Illinois at Urbana-Champaign and USDAAgricultural Research Service.
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773. REDOX SIGNALING Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B346 773.1 The Intrinsically Disordered Membrane Enzymes Selenoprotein S and Selenoprotein K. S. Rozovsky, J. Liu, Z. Zhang. University of Delaware. B347 773.2 The Nucleotide Exchange Factor Sil1 Modulates Redox Signaling Through the Molecular Chaperone BiP. K. Siegenthaler, K. Pareja, J. Wang, C. Sevier. Cornell University. B348 773.3 A Novel Mediator of Heart Failure Development and Progression. S. Miriyala, M. Panchatcharam, M. Chandra, B. Maxey, w. Orr, L. Harrison, K. McCarthy, S. Bhuiyan, C. Kevil. LSUHSC-Shreveport. B349 773.4 Hydrogen Sulfide Homeostasis and Signaling in Normal and Neoplastic Intestinal Cells. M. Libiad, N. Sakamoto, E. Fearon, R. Banerjee. University of Michigan. B350 773.5 Lipid-Derived Electrophiles Regulate IsoformSpecific Redox-Dependent Kinase Signaling. S. Surya, S. Parvez, M.J. Long, Y. Zhao, J. Haegele, P. Huang, Y. Aye. Cornell University and Weill Cornell Medicine. B351 773.6 4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption by Modulating Thioredoxin System and Mitochondrial Ros Generation Independently. S.A. Ansari, U.R. Pendurthi, L.M. ‘Rao. University of Texas Health Science Center at Tyler. B352 773.7 Hydrogen Sulfide Oxidation by Myoglobin. T.M. Bostelaar. University of Michigan. B353 773.8 Characterization of Glutathione Flux Between Subcellular Compartments. C.E. Outten, M. Darch, C. McGee. University of South Carolina. B354 773.9 Molecular Basis for Redox Regulation of the Src Kinase. D.E. Heppner, C.M. Dustin, C. Liao, M. Hristova, B. Deng, Y. Lam, J. Li, A. van der Vliet. University of Vermont.
MONDAY BIOCHEMISTRY
774. APOPTOSIS AND CELL DEATH Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B355 774.1 Enhanced Aggressiveness of Bystander Cells in an Anti-Tumor Photodynamic Therapy Model: Role of Nitric Oxide Produced by Targeted Cells. A. Girotti, J. Bazak, J. Fahey, W. Korytowski. Medical College of Wisconsin and Jagiellonian University, Poland. B356 774.2 H/D Exchange Mass Spectrometry Reveals Calmodulin-Controlled Regulatory Interactions in Neuronal Nitric Oxide Synthase. J.R. Carley, M.F. Barrett, T.J. Gilbreath, E.S. Underbakke. Iowa State University. B357 774.3 Mapping Calmodulin-Induced Oxidase Domain Interactions of Neuronal Nitric Oxide Synthase Using H/D Exchange Mass Spectrometry. M.F. Barrett, J.R. Carley, E.S. Underbakke. Iowa State University. B358 774.4 Stay on Target: Deconvoluting Mixed Redox Messages Through Precision Redox Targeting. Y. Aye. Cornell U & Weill Cornell Med. B359 774.5 Cation-Independent Mannose 6-Phosphate Receptor Interacts with Several Components of the Plasminogen Activation System. R. Bohnsack, J. Miller, S. Twining, L. Olson, N. Dahms. Medical College of Wisconsin. B360 774.6 Probing the Activation Mechanism of BAK in Mitochondrial Apoptosis. M. Tesney, G. Singh, C. Guibao, T. Moldoveanu. Winthrop University and St. Jude Children’s Research Hospital. B361 774.7 Inhibition of Apoptosis in Glutamine-Starved Mouse Hybridoma Cells by Ammonium Ions and DON, a Glutamine Analog. E.R. Gauthier, C. Zhou, A. Abusneina. Laurentian University, Canada. B362 774.8 Interaction Between FAM129B, a Novel Adherent Junction Protein, and KELCH-Like Associated Protein 1 (KEAP1) Suppresses Apoptosis in Cancer Cells. F.A. Hachem, S.A. Chen, H.G. Evans, D.R. Evans. Wayne State University and Eastern Michigan University. B363 774.9 Pro-Death Bax Has an Intrinsic Capability to Induce Aggregate-Dependent Caspase 8-Mediated Cell Death. A. Manas, S. Wang, J. Li, A. Nelson, A. Davis, S. Lamerand, H. Zhang, J. Xiang. Illinois Institute of Technology and University of Chicago. B364 774.10 Induction of Apoptosis in Carcinoma Cells: Perhaps It Is Right Way to Kill the Metastatic Process. S. Basu, M. Basu, R. Ma, J. Moskal. University of Notre Dame, Siemens Corp., People’s Republic of China, and Northwestern University. B365 774.11 Gene Expression of SEB-Induced C-Jun N-Terminal Kinase Apoptosis Pathway in Human PBMCs. M. Hendricks, D. Borgos, J. Butzen, A. Watson, C. Mendis, M. Jett. University of Wisconsin Platteville and Systems Biology Enterprise US Army Medical Command (MEDCOM).
B366 774.12 Post-Transcriptional Modulation of MCL1 by PTBP1 Regulates Cellular Apoptosis Induced by Antitubulin Chemotherapeutics. J. Cui, W.J. Placzek. University of Alabama at Birmingham. B367 774.13 Genetic Characterization of Programmed Cell Death in Aneuploid Yeast Cells. M. Sanborn, V. Timmel, J. Barrios, T. McBride, R.S. Pinches, N. Austriaco. Providence College. B368 774.14 The Effect of Compound L19 on Human Colorectal Cells (DLD-1). S. Mohammadhosseinpour, B. Clack. Stephen F. Austin State University. B369 774.15 Intracellular Zinc Trafficking and Metallothionein Gene Activation in HUVEC Treated with Crotalus atrox Venom. E. Albrecht, V. Garbar, S. Tomlins, E. Williams. Kennesaw State University and University of Michigan Medical School. B370 774.16 Activation of Caspase-8/BID Pathway in Dexamethasone-Induced Apoptosis in a Human Lens Epithelial Cell Line. M.S. Ali. William Beaumont Army Medical Center. B371 774.17 Misoprostol-Induced Activation of NF-κB Functions to Repress the Bnip3 Cell Death Pathway in Neonatal Hypoxia. M.D. Martens, J. Field, Y. Hai, W. Mughal, S. da Silva Rosa, C. Blaney, T. Ivanco, W. Diehl-Jones, J.W. Gordon. University of Manitoba, Canada. B372 774.18 Antioxidant and Anti-Proliferative Activity of Fractions from Anona senegalensis Pers (Annonaceae) Stem Bark on HeLa Cells. R.A. Adisa, G.T. Getti, S.C. Richardson. University of Lagos, Nigeria and University of Greenwich, United Kingdom. B373 774.19 Understanding the Role of BCL-2 Proteins in Hyperglycemia-Induced Apoptosis in Cardiomyocytes. S. Miller, V. Del Gaizo Moore. Elon University. B374 774.20 The NPM1 Inhibitor NSC348884 Induces Apoptosis in Neuroblastoma Cells. K. Kristjansdottir, N. Akgul, K. Vlcek. Midwestern University. B375 774.21 Effect of Methyglyoxal and Curcumin on PC12 and RINm5f Cells. V. Puccini de Castro, S. Keys, J. Su, S. Mungre. Northeastern Illinois University. B376 774.22 Bcl-2 Dependency in Cell Culture and Mouse Models of Sepsis-Associated Acute Kidney Injury. K.A. Lynch, V. Del Gaizo Moore. Elon University. B377 774.23 NF-κB Promotes Alternative Splicing of Bnip3 During the Cellular Adaptation to Hypoxia. J. Field, M. Martens, W. Mughal, S. da Silva Rosa, J. Gordon, W. Diehl-Jones. University of Manitoba, Canada and Athabasca Unversity, Canada. B378 774.24 Synthesis of a Novel Endoperoxide and Evaluation of the Drug’s Ability to Induce Apoptosis in Colon Cancer Cells. J.R. Devlin, E.S. Gornick, T.R. Vavrek, D.M. Rubush, J. Sarathy. Benedictine University. B379 774.25 Analysis of the Functional Relationship Between the Kaposi Sarcoma-Associated Herpesvirus (KSHV) VBcl-2 Protein and the Pro-Apoptotic Host Protein, BIK. K. Hixon, J. Roecklein-Canfield. Simmons College. B380 774.26 A Flow Cytometry Analysis of Apoptosis Reversibility in Mammalian Lymphocytes Following Cytokine Deprivation. A. Parnes, R. Lauzon. Union College. B381 774.27 UV Irradiation/Cold Shock-Induced Bubbling Death Is Ca2+-Dependent. C-C. Tsai, Y-W. Chen, N-S. Chang. National Cheng Kung University College of Medicine, Taiwan.
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BIOCHEMISTRY MONDAY
775. CANCER SIGNALING AND THERAPEUTICS (I) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Cancer Signaling and Therapeutics (II), Tuesday B382 775.1 Mortalin Modulates MEK/ERK Activity by Regulating the Physical Interaction Between MEK1/2 and Protein Phosphatase 1 Alpha. P. Wu. Medical College of Wisconsin. B383 775.2 Targeting Cancer Progression Genes Upregulated in CREBL1-Deficient Breast Cancer Cells. S. Smith, F. Goubran, P. Mellor, D. Anderson. University of Saskatchewan, Canada. B384 775.3 Manipulating the Bone Marrow Microenvironment to Prevent Survival of AML Cells. R.M. Sterner, K.N. Kremer, A. Dudakovic, J.J. Westendorf, A.J. van Wijnen, K.E. Hedin. Mayo Clinic. B385 775.4 Leveraging Synthetic Lethality to Target Convergent Therapeutic Resistance. K.C. Wood. Duke University. B386 775.5 ATG5 Knockout Leads to Malignant Cell Transformation and Resistance to Src Family Kinase Inhibitor PP2. M. Lee, S. Hwang. Incheon National University, Republic of Korea. B387 775.6 Modelling the Effects of Laser Photothermal Therapy on Proteins HSP70 and P53. A. Milcarek, K. Daus, M. Alpaugh, T. Dobbins. Rowan University. B388 775.7 Pim-1 Signaling in Drug-Resistant Colon Cancer Cells Promotes Cell Survival and Chemoresistance Through Up-Regulation of Lactate Production. G. Park, D. Kim. Kosin University College of Medicine, Republic of Korea, Inje University College of Medicine, Republic of Korea. B389 775.8 Differential Inhibitory Effects of Nocodazole on Human Hematopoietic and Hepatocytic Cells and Their Stem/ Progenitors in Culture. J. Baquier, H. Darrell, S. Brumaire, L. Schoonover, T. Hu. Barry University. B390 775.9 (A3)Beating Cancer: Impact of APOBEC3B on 5-Fluorouracil Treatment. S.R. Fine. College of Wooster. B391 775.10 Differential Phosphatidylserine Sensing by TAM Receptors Regulates AKT Dependent Chemoresistance and PD-L1 Expression in Epithelial Cells. C. Kasikara, S. Kumar, R. Birge. Rutgers University. B392 775.11 Overcoming Resistance to Anti-EGFR Therapy in Breast Cancer with Rac Inhibitors. L.D. Borrero-Garcia, A.L. Troche-Torres, M. Maldonado, S. Dharmawardhane. University of Puerto Rico, Medical Sciences Campus, Puerto Rico, University of Puerto Rico and Rio Piedras Campus, Puerto Rico. B393 775.12 Targeting Both Aberrant Metabolism and Cell Proliferation in Cancer Therapy. B. Gibbs, C.P. Masamha. Butler University.
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B394 775.13 CCN5/WISP-2 Activates Estrogen Receptor-α in Normal and Cancerous Breast Epithelial Cells and Sensitizes Them to Hormonal Therapy. S. Sarkar, A. Ghosh, S. Banerjee, G. Maity, A. Das, V. Gupta, I. Haque, O. Tawfik, M. Larson, S. Banerjee. University of Kansas Medical Center, Kansas City VA Medical Center, Kansas City VA Medical Center and University of Calcutta, India. B395 775.14 Identification of Novel Variants of the CB1 Cannabinoid Receptor in Cancer Cells. A.Yarbrough, S. Pyrek, L. Wood, A. Urbaniak, J. Bush, P. Prather, A. RadominskaPandya. University of Arkansas at Little Rock and University of Arkansas for Medical Science. B396 775.15 Attenuation of γ-Secretase Mediated Activation of Notch Signaling Induces Autophagic Cell Death in Triple Negative Breast Cancer Cells. A. Das, A. Ganguli, K. Narayanam, P. Mukherjee, B. Basu, U. Chatterjee, S. Banerjee, P. Karmakar, D. Kumar, G. Chakrabarti. Jadavpur University, India, Calcutta University, India, University of California, Calcutta University, India, Amity University, India, VA Medical Center, University of Kansas Medical Center and Birla Institute of Science & Technology, India. B397 775.16 Activation of Cyr61 Signaling in Solid Tumor Cells Diminishes Response to a Histone Deacetylase Inhibitor: Challenges for HDACIs. A. Ghosh, P. Ghosh, G. Maity, S.K. Banerjee, S. Banerjee. University of Kansas Medical Center and VA Medical Center. B398 775.17 Aspirin: A Regulator of Tumor Angiogenesis in Breast Cancer. G. Maity, J. Chakraborty, S. Banerjee, S.K. Banerjee. Kansas University Medical Center, VA Medical Center and Blue Valley West High School. B399 775.18 Rosehip (Rosa canina) Extracts Prevent AKT and MAPK-Mediated Cell Proliferation in Triple Negative Breast Cancer Cells. P. Cagle, P. Martin. North Carolina A & T State University. B400 775.19 SRC Regulates Proliferation in ER+ Breast Cancer Cells by Stabilizing MYC mRNA. C. Abdullah, H. Korkaya, S.A. Courtneidge. Oregon Health & Science University, UC San Diego and Augusta University. B401 775.20 Gemcitabine-Induced Exosome Hypersecretion Increases the Chemoresistance and Migration of Pancreatic Cancer Cells. R. Sweeney, K.E. Richards, R. Hill. University of Notre Dame and Harper Cancer Research Institute. B402 775.21 Using a CRISPER/Cas9 Knockout to Evaluate the Role of Furin in the Intoxication Pathway of Pseudomonas Exotoxin A. J. Sanford, Y. Zhu, J. Weldon. Towson University. B403 775.22 DDB2 Activates Rnf43 and Regulates Wnt/βCatenin Signaling in Colorectal Cancer Cells. S. Huang, D. Fantini, B. Merrill, S. Bagchi, P. Raychaudhuri. University of Illinois at Chicago, Northwestern University and Jesse Brown VA Medical Center. B404 775.23 Investigation of Affinity at Binding Site Between Human Epidermal Growth Factor Receptor 2 (HER2) and Herceptin. M. Kondrashova, B. Miller. Truman State University.
MONDAY BIOCHEMISTRY
776. PARASITE-HOST INTERACTIONS
777. ANTIBIOTIC RESISTANCE
Poster
Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:00 pm–2:30 pm
Presentation time: 12:00 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
B405 776.1 Genetic Variants of Tumor Necrosis Factor-α (rs1800629) Gene Enhances Susceptibility to Malaria Infection in West Africa. T. Snyder, J. Noble, R. Funwei, C. Falade, O. Ojurongbe, B.N. Thomas. Rochester Institute of Technology and Ladoke Akintola University of Technology, Nigeria. B406 776.2 Extensive Interethnic Diversity of Cytokine Interleukin-10 Promoter Gene (rs1800872) Single Nucleotide Polymorphisms and Association with Malaria Infection. N. Aziz, S. Adedokun, T.J. Snyder, I. Farid, O. Ojurongbe, B. Thomas. B407 776.3 Evaluation of the Immune Response Induced in Mice by a Recombinant Form of SPO-1, a Schistosoma mansoni Modulatory Protein. W.d. Bernardes, C.C. Alves, R.A. Pereira, C.T. Fonseca. Rene Rachou Research Center, Brazil. B408 776.4 Polar Lipid in Human Blood Regulates Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. J.P. Gerdt, N.M. Brancucci, C. Wang, S.R. Adapa, M. Zhang, J.H. Adams, R.H. Jiang, M. Marti, J. Clardy. Harvard Medical School, University of Glasgow, United Kingdom, Harvard T.H. Chan School of Public Health and University of South Florida. B409 776.5 Genetic Mapping of Strain Specific Differences in Autophagy Effector Recruitment to the Toxoplasma gondii Parasitophorous Vacuole. J.B. Radke, L. Sibley. Washington University School of Medicine. B410 776.6 Molecular Characterization and Pathogenicity of Meloidogyne incognita on Tomato Cultivars (Solanum lycopersicon L.). M. Abdulai, B.C. Cole, B. Fawole. Akdeniz University, Turkey and University of Ibadan, Nigeria. B411 776.7 Overcoming Challenges in the Diagnosis of Schistosoma mansoni Infections Using POC Tests, Recombinant Protein and Monoclonal Antibody Technology. R.F. Queiroz, R. Cruz, M. Pedrosa, M. Oliveira, W. Jeremias, J. Assis, L. Coutinho, D. Taboada, V. Moraes, L. McEwen, D. Harn, P. Coelho. FIOCRUZ, Brazil and University of Georgia. B412 776.8 Discovery Recovery Methods and Detection of Food Borne Parasites. A. Aralu. University of Georgia. B413 776.9 Toxoplasma gondii Infection Reprograms Monocyte Adherence and Motility. L.L. Drewry, L. Sibley. Washington University. B414 776.10 Fatty Acid Resource Allocation and the Survival of African Trypanosomes in the Host Bloodstream. K.S. Paul, C.A. McKnight, P.A. Vigueira. Clemson University.
B415 777.1 Anti-Fluoroquinolone Resistance Activity of E558: A Natural Product. W.O. Iyanda-Joel, E.A. Omonigbehin, E.E. Iweala, S.N. Chinedu. Covenant University, Nigeria. B416 777.2 Discrete Structural Dynamics of PseudoPalindromic Motifs Control DNA Binding of Bacterial ToxinAntitoxin Complexes. D.E. Brodersen, K.L. Bendtsen, K. Xu, M. Luckmann, K. Winther, S.A. Shah, C.N. Pedersen. Aarhus University, Denmark and University of Copenhagen, Denmark. B417 777.3 Genesis of Antibiotic Resistance XXII: Mutagenic Potential of the River Ganga (RG): Segment I, II, IIIa,b,c, Vacate Hardy-Weinberg-Castle Equilibrium (HWCE), and Concoct as a Plausible Contributor to an Imminent Antibiotic Resistance Pandemic (ARP). M. Francisco, H. Montoya, J. Flores, C. Carbajal, C. Wickham, C. Lopez, D. Johnson; Jr., S. Kannan. City of Eagle Pass Water Works and Southwest Texas Junior College. B418 777.4 Genesis of Antibiotic Resistance XXIII: The River Ganga (RG)-Segment IVB, Secede Hardy-WeinbergCastle Equilibrium (HWCE), and Concoct as Cataclysmic Epicenter of Antibiotic Resistance Pandemic (ARP). F. Martinez, E. Fuentes, H. Montoya, J. Flores, C. Carbajal, C. Wickham, C. Lopez, D. Johnson; Jr., S. Kannan. City of Eagle Pass Water Works and Southwest Texas Junior College. B419 777.5 Genesis of Antibiotic Resistance XXIV: Impediments in Implementation of Antibiotic Time Out (ATO) to Mitigate Antibiotic Resistance Pandemic (ARP): A Sniffle for Inclusive Approach. R. Lehler, A. Picazo, S. Blackmon, D. Asplaugh, R. Fielder, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College. B420 777.6 Genesis of Antibiotic Resistance XXI NonExistent F-Tag-428 Implementation in Developing Countries, Exacerbate Genesis of Antibiotic Resistance (AR). C. Carbajal, E. Fuentes, C. Wickham, C. Lopez, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College. B421 777.7 Genesis of Antibiotic Resistance XXV: Mitigation of Antibiotics Resistance Pandemic (ARP) by Immediate Moratorium on Effluent Discharge Practices from Antibiotics Manufacturing Pharmaceutical Industry. C. Carbajal, E. Fuentes, C. Wickham, C. Lopez, D. Carrizales, T. Carrizales, S. Jauregui, R. Thomas, R. Lechler, J. Beautnagel, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College. B422 777.8 Genesis of Antibiotic Resistance XXVI: Mitigation of Antibiotic Resistance Pandemic (ARP) by Obdurate Implementation of Guidelines at the International Border Crossing. C. Carbajal, A. Picazo, S. Gutierrez, S. Blackmon, G. Perez, A. Gonzalez, E. Fuentes, C. Wickham, C. Lopez, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College.
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BIOCHEMISTRY MONDAY B423 777.9 Genesis of Antibiotic Resistance XXVII: Action Plan for Global Union for Antibiotics Research and Development (GUARD) to Mitigate AR Pandemic (ARP). E. Fuentes, C. Wickham, C. Carbajal, C. Lopez, S. Jauregui, R. Lechler, S. Gutierrez, S. Blackmon, A. Gonzalez, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College. B424 777.10 Genesis of Antibiotic Resistance XXVIII: Mitigation of Antibiotic Resistance Pandemic (ARP) Through Obdurate Implementation of Antibiotics Time Out (ATO). J. Martinez, E. Anaya, M. Calzoncit, A. Moran, M. Francisco, H. Montoya, J. Flores, A. Picazo, S. Blackmon, S. Jauregui, R. Lechler, J. Beautnagel, S. Gutierrez, D. Johnson; Jr., S. Kannan. Fort Duncan Reginal Medical Center, Southwest Texas Junior College and City of Eagle Pass Water Works. B425 777.11 Genesis of Antibiotic Resistance XXIX: Clinical Perspectives of Obdurate Implementation of Antibiotics TimeOut (ATO) in Mitigating Antibiotic Resistance Pandemic (ARP). E. Anaya, J. Martinez, M. Calzoncit, A. Picazo, S. Blackmon, S. Jauregui, R. Lechler, J. Beautnagel, S. Gutierrez, D. Johnson; Jr., S. Kannan. Fort Duncan Regional Medical Center and Southwest Texas Junior College. B426 777.12 Genesis of Antibiotic Resistance (AR) XXX: Mitigation of AR Pandemic (ARP) Through Rational Measures. S. Blackmon, M. Francisco, H. Montoya, J. Flores, E. Anaya, J. Martinez, M. Calzoncit, A. Picazo, S. Jauregui, R. Lechler, J. Beautnagel, S. Gutierrez, D. Johnson; Jr., S. Kannan. Southwest Texas Junior College, City of Eagle Pass Water Works and Fort Duncan Reginal Medical Center. B427 777.13 Transformations of Antibiotics in Water Systems and the Impact on Specific Microbes. A. Beavan, A. Bhatnagar, Z. Henkes, J. Peller, S. Dick. Valparaiso University. B428 777.14 Gyrase Inhibition by Toxin-Antitoxin Modules. C.R. Bourne, J.C. White, S. Dabadi, M. Muthuramalingam. University of Oklahoma. B429 777.15 Isolation, Expression, and Characterization of a β-Lactamase Produced by Meiothermus ruber. L. Grulke, A. Bergstrom, T. Groen, E. Analitis, L. Scott, P. Crawford. Augustana College. B430 777.16 Yeast-Based Immunotherapy Against Clostridium difficile Infection. Y. Zhu, H. Feng. University of Maryland. B431 777.17 Streptococus mitis and Streptococcus oralis Mutate an “Essential” Gene upon Exposure to Daptomycin. H. Adams, L. Joyce, Z. Guan, R. Akins, K. Palmer. University of Texas at Dallas, Duke University Medical Center and Methodist Charlton Medical Center. B432 777.18 Effects of Over-Expression of RecA on Transformation in Bacillus subtilis. S. Penumutchu, B. Korry, P. Belenky. University of Maryland, Baltimore County and Brown University. B433 777.19 Biochemical Characterization of Type II Toxin- Antitoxin Module from Pseudomonas aeruginosa. M. Muthuramalingam, J.C. White, C.R. Bourne. University of Oklahoma. B434 777.20 Synthesis and Antibacterial Activity of Novel Semi-Synthetic Triterpenoids. G. Da Silva, M. Pereira, J.D. Salvador. Lab. of Microbiology, Fac. of Pharmacy, University of Coimbra, Portugal, Center for Neurosciences and Cell Biology, University of Coimbra, Portugal, Lab. of Pharmaceutical Chemistry, Fac. of Pharmacy and University of Coimbra, Portugal.
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B435 777.21 New Delhi Metallo-Beta-Lactamase Variants NDM-4 and NDM-12 from E. coli Clinical Isolates Exhibit Increased Activity and Stability. C. Williams, J. VanPelt, R. Poth, K. Cottingim, A. Stewart, J.C. Nix, W. Fast, D.L. Tierney, M.W. Crowder, R.C. Page. Miami University, University of Texas at Austin and Lawrence Berkeley National Laboratory. B436 777.22 Multidrug Resistance and High Prevalence of Class 1 Integrons in Escherichia coli Isolated from Irrigation Water and Vegetables in Parts of Nsukka and Enugu, Nigeria. C.B. Chigor, I.I. Ibangha, V.C. Onuora, O.E. Omotosho, T. Chernikova, V.N. Chigor, P. Golyshin. Chukwuemeka Odumegwu-Ojukwu University, Nigeria, University of Nigeria, Nigeria, Covenant University, Nigeria and Bangor University, United Kingdom. B437 777.23 The Structure of EmrE and Its Role in Antibiotic Resistance. J. Kenana, B. Langat, C. Kalicki, E. Inthavong, A. Kanna. Olathe North High School. B438 777.24 Functional Analysis of Toxoplasma gondii cGMP-Dependent Protein Kinase Isoforms Using an AuxinInducible Degron System. K.M. Brown, S. Long, L. Sibley. Washington University School of Medicine.
778. ENERGY METABOLISM, OXIDATIVE PHOSPHORYLATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B439 778.1 Determining the Rhodoquinone Biosynthetic Pathway in Rhodospirillum rubrum Using Gene Knock-Outs. A. Martin, J. Shepherd. Gonzaga University. B440 778.2 Effect of the Mitochondrial DNA 4977-bp “Common Deletion” on Metabolism and Cell Growth in Human Lymphoblast Cell Lines. C. Keck, M. Gulfo, R. O’Donnell, H. Hoops, W. Pogozelski. SUNY Geneseo and Albert Einstein College of Medicine. B441 778.3 Leigh Syndrome French Canadian Type Patient Fibroblasts Exhibit Energy Metabolism Adaptations Through a Warburg-Like Effect. Y. Mukaneza, A. Cohen, M. Rivard, J. Tardif, C. Laprise, C. Des Rosiers, L. Coderre. Montreal Heart Institute, Canada, Université de Montréal, Canada, The Hebrew University of Jerusalem, Israel and Université de Québec à Chicoutimi, Canada. B442 778.4 Increased N-Acetyltaurine in the Skeletal Muscle After Endurance Exercise. T. Miyazaki, Y. Nakamura, K. Ebina, S. Ra, K. Ishikura, H. Ohmori, T. Ikegami, Y. Matsuzaki, A. Honda. Tokyo Medical University Ibaraki Medical Center, Japan, University of Tsukuba, Japan, Fukuoka University, Japan and Sojo University, Japan. B443 778.5 Hydrodynamic Delivery of Isocitrate Dehydrogenase II for the Treatment of Acute Kidney Injury. A. Kolb, S. Atkinson, R. Bacallao. Indiana University Purdue University Indianapolis, Roudebush VAMC and Indiana University School of Medicine. B444 778.6 Elucidating the Biosynthetic Pathway of Rhodoquinone in Caenorhabditis elegans S. Babcock, J. Shepherd. Gonzaga University.
MONDAY BIOCHEMISTRY B445 778.7 Expression of Hepatic Acetyl-CoA Carboxylase (ACACA) in Mice (Mus musculus) Exposed in Utero to Atrazine. A. Wimmer. Saint Mary’s University of Minnesota. B446 778.8 O-GlcNAc Is Critical for the Regulation of Energy Metabolism. E. Tan, S. McGreal, S. Graw, R. Tessman, S. Koppel, P. Dhakal, Z. Zhang, M. Machacek, M.J. Soares, N. Zachara, D. Koestler, K.R. Peterson, J.P. Thyfault, R.H. Swerdlow, P. Kasturi, U. Apte, C. Slawson. University of Kansas Medical Center, The Johns Hopkins University of Medicine and University of Kansas Alzheimer’s Disease Center. B447 778.9 Stimulation of Astrocyte Fatty Acid Oxidation Increases Spare Respiratory Capacity Under NutrientDeprived Conditions. M. Sifuentes, J. Lechleiter. University of Texas Health Science Center at San Antonio.
779. OXIDATIVE STRESS AND REACTIVE OXYGEN Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B448 779.1 Acute Oxidative Challenge Induces Glucose Uptake Through AMPK-Mediated NO Production in Skeletal Muscle. D.L. Kellogg, K. McCammon, B. Masters, L. Roman. UTHSCSA and Duke University. B449 779.2 S-Nitrosylation Is Responsible for Muscle Atrophy and Weakness in GNE Myopathy. M. Miyakawa, A. Cho, M.C. Malicdan, I. Nishino, S. Noguchi. National Institute of Neuroscience, Japan, Ewha Womans University School of Medicine, Republic of Korea, National Institute of Health and National Institutes of Health. B450 779.3 Inflammatory Stress Induces a Biphasic Nrf2 Activation in Neuronal Cells. S.A. Krepel, L. O’Hara, S. Mangum, M.B. Hogan, T.B. Kuhn. University of Alaska Fairbanks and Fairbanks West Valley High School. B451 779.4 Exploring the Role of Trehalose-6-Phosphate Synthase in Oxidation and Desiccation Stress Tolerance of Fusarium verticillioides. N.R. Oberlie, S.D. McMillan, P.N. Pierson, N.S. Bonich, D.W. Brown, K.L. McQuade. Bradley University and USDA-ARS-NCAUR. B452 779.5 Fruit Extract of Thaumatococcus daniellii Reduces Oxidative Stress in Rats. F.N. Iheagwam, S.N. Chinedu, O.C. Emiloju, A.C. Okenmuo. Department of Biological Sciences, College of Science and Technology, Covenant University, Nigeria, Department of Biological Sciences, College of Science and Technology and Covenant University, Nigeria. B453 779.6 Cross-Talks Between Intracellular Zinc Increases and Reactive Oxygen Species in Hypoxia. K. Slepchenko, Y.V. Li. Ohio University. B454 779.7 Effect of Maternal Separation on Oxidative and Nitrosative Stress in the Brain of Rat Offspring. A. CamposRangel, L. Torner-Aguilar, A. Saavedra-Molina, S. ManzoAvalos. Universidad Michoacana de San Nicolás de Hidalgo, Mexico, Centro de Investigación Biomédica de Michoacán and IMSS, Mexico.
780. DIABETES, OBESITY AND METABOLIC SYNDROME (I) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Diabetes, Obesity and Metabolic Syndrome (II), Tuesday B455 780.1 Lactotransferrin Prevents Hepatic Steatosis Through Inhibition of Hepatic Dietary Lipid Uptake in Hormone Disturbance Non-Alcoholic Fatty Liver Disease Model. S. Lee, B. Son, G. Park, W. Kim, H. Youn, B. Youn. Pusan National University, Republic of Korea, and Sejong University, Republic of Korea. B456 780.2 Adiponectin Receptor 1 Resists the Decline of Serum Osteocalcin and GPRC6A Expression in Ovariectomized Mice. Y. Lin, C. Chen, S. Wu, S. Ding. National Taiwan University, Taiwan and Institute of Biotechnology, Taiwan. B457 780.3 Use of a Three Dimensional Porcine Retinal Explant Model to Detect HIF1α for Understanding Diabetic Retinopathy. B. Iwuagwu, S.F. Cruickshank, I. Rowe, R.M. Knott. Robert Gordon University, United Kingdom. B458 780.4 Niclosamide Blocks Glucagon Phosphorylation of Serine 552 on β-Catenin Leading to Decrease Target Genes Expression and Improve Glucose Metabolism via PKA Signalling Pathway. M.H. Chowdhury, M. Morris, N. Turner, L. Wu, P. Shepherd, G. Smith. UNSW Australia, Australia and University of Auckland, New Zealand. B459 780.5 Potential Role of Dietary Fat- and ObesitySensitive Adipose PKCbeta Signaling in Pathophysiology of Adipose Dysfunction. N.K. Mehta, W. Huang. Northeastern Ohio College of Medicine and The Ohio State University College of Medicine. B460 780.6 Diabetic Nephropathy Accelerated by Imbalance of Renal Renin-Angiotensin System Components in db/db Mice with High Fat Diet. G. Wang, C. Cho, C. Lin, H. Wu, C. Lin. National Chiao Tung University, Taiwan and National Chia Yi University, Taiwan. B461 780.7 Prohibitin Has Sex Dimorphic Role in Adipose and Immune Functions. Y. Xu, S. Ande, S. Mishra. University of Manitoba, Canada. B462 780.8 Regulation of Hepatic Inflammation by Folic Acid in Non-Alcoholic Fatty Liver Disease (NAFLD). V. Sid, Y. Shang, C. Siow, K. O. University of Manitoba, Canada, CCARM, St. Boniface Research Center, Canada and Agriculture and Agri-Food Canada, Canada. B463 780.9 Lack of Efficient Metabolism Adaption Caused Failure of Regenerative Cell-Based Therapy in a Rat Model of Metabolic Syndrome. A. Jamaiyar, W. Wan, D. Janota, M. Enrick, V. Ohanyan, L. Yin, W. Chilian. Northeast Ohio Medical University and Kent State University. B464 780.10 Impact of VEGF Gene Polymorphisms on Progression of Diabetic Retinopathy in an Indian Population. D. Jajal, K. Kalia. Sardar Patel University, India and National Institute of Pharmaceutical Education & Research (NIPER— Ahmedabad), India.
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BIOCHEMISTRY MONDAY B465 780.11 Altered Islet Function May Promote a Lean Phenotype in Tafazzin Deficient Mice. L.K. Cole, C. Doucette, M. Vandel, M. Fonseca, B. Xiang, V.W. Dolinsky, G.M. Hatch. University of Manitoba, Canada. B466 780.12 Lipid Stress Alters Cell Distribution, Traffic, and Desensitization Properties of Melanocortin-4 Receptor, a GPCR Involved in Appetite Control. K. Cooney, B. Molden, S. Russell, G. Baldini. University of Arkansas for Medical Sciences. B467 780.13 Mitochondria-Targeted Catalase Primes Adipocyte Differentiation Through Regulation of Pref-1. K. Tavares, B. Christian. Appalachian State University. B468 780.14 ‘Ome Is Where the Wound Is: Biomarkers of Healing in Chronic Diabetic Foot Ulcers. M. Glucksman, K. Philibert, X. Shao, C. Yang, J. Ortiz, S. Wu. Chicago Medical School and Scholl College of Podiatric Medicine. B469 780.15 Investigation of Free Fatty Acid on Concerted Trafficking of KATP and Kv2.1 Channels in the Adipoinsular Axis in Vivo and in Vitro. J. Ruan, P. Chen. National Cheng Kung University, Taiwan.
781. LIPID METABOLIZING ENZYMES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B470 781.1 The Activation Loop of PIP5K Functions as a Membrane Sensor Essential for Processing of Lipid Substrates. J. Hu. Michigan State University. B471 781.2 The Nem1-Spo7/Pah1 Phosphatase Cascade Is Negatively Regulated by Protein Kinase A. W. Su, G. Han, G.M. Carman. Rutgers University. B472 781.3 Structure-Function Analysis of Yeast Pah1 Phosphatidate Phosphatase. Y. Park, G. Han, G.M. Carman. Rutgers University. B473 781.4 Potential Role of Hepatic Lipase in the Accrual of Docosahexaenoic Acid (DHA) in the Brain. S. Dhavamani, P. Yang, D. Ng, S. Khetarpal, C. Vitali, D. Rader, P. Subbaiah. University of Illinois, University of Toronto, Canada and University of Pennsylvania. B474 781.5 Dual Site Mechanism Governs Sphingosine Kinase 1 Membrane Binding and Biological Function. M. Pulkoski-Gross, J. Truman, M. Salama, C. Clarke, Y.A. Hannun, L. Obeid. Stony Brook University and Mansoura University, Egypt. B475 781.6 Monoacylglycerol Acyltransferase (MGAT) 1 and 2 Play Divergent Roles in Adipogenesis/Lipogenesis in Mice. T. Huang, M. Yen, D.W. Nelson, C. Yen. University of Wisconsin-Madison.
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B476 781.7 Biochemical Characterization of a Mycobacterial Acyltransferase Involved in the Metabolism of Long-Chain Fatty Acids. J. Law, J. Daniel. Indiana UniversityPurdue University Fort Wayne. B477 781.8 Crystal Structure and Activation Mechanism of Human Neutral Sphingomyelinase 2. P. Shanbhogue, M. Airola, A. Shamseddine, K. Guja, R. Maini, N. Bartke, B. Wu, L. Obeid, M. Garcia-Diaz, Y. Hannun. Stony Brook University and Medical University of South Carolina. B478 781.9 Characterization of Saccharomyces cerevisiae Coenzyme Q Biosynthetic Protein Coq11. M.C. Bradley, A.M. Awad, C.M. Allan, J.S. Johnson, D.I. Shirasaki, C. Wang, C.E. Blaby-Haas, J.A. Loo, C.F. Clarke. University of California, Los Angeles and University of Michigan. B479 781.10 Mutational Analysis of the Arabidopsis thaliana Lysoglycerophospholipid Acyltransferase AT1g78690. S. Nag, T.A. Garrett. Vassar College. B480 781.11 The Cardiotoxic and Cardioprotective Potential of Cytochrome P450 2J2 (CYP2J2). W.R. Arnold, J. Baylon, E. Tajkhorshid, A. Das. University of Illinois Urbana-Champaign. B481 781.12 AGPAT4 Is a Mitochondrial Lysophosphatidic Acid Acyltransferase That Regulates Learning and Memory in Mice. R. Bradley, E.B. Mardian, A.S. Mitchell, D. Bloemberg, P. Marvyn, E. Bombardier, K. Moes, A. Tupling, J. Quadrilatero, R.E. Duncan. University of Waterloo, Canada. B482 781.13 Investigation of a Role for AGPAT4 in Mouse Skeletal Muscle. R.M. Bradley, D. Bloemberg, A.S. Mitchell, V.A. Fajardo, J. Aristizabal Henao, C. Bellissimo, E.B. Mardian, M. Paré, E. Bombardier, K. Moes, A. Tupling, J. Quadrilatero, K.D. Stark, R.E. Duncan. University of Waterloo, Canada. B483 781.14 Saccharomyces cerevisiae Coq10, a Putative START Domain Protein Binds Coenzyme Q and Late-Stage Q-Biosynthetic Intermediates. H. Tsui, C. Clarke. UCLA. B484 781.15 A Conserved Putative Kinase Is Required for Coenzyme Q Biosynthesis: Functional Insights from Yeast Genetics. N.V. Pham, C. Clarke. University of California at Los Angeles. B485 781.16 Elevated Uptake of Glycerophosphoinositol Through the Git1 Permease Causes Cell Growth Inhibition in Saccharomyces cerevisiae. P. Ziegler, A. Nikiforov, B. Robinson, A. Bakalinsky, A. O’Donnell, J. Patton-Vogt. Duquesne University and Oregon State University. B486 781.17 Identification of Inhibitors of ACSVL3, a Therapeutic Target in Glioma. E. Clay, X. Shi, Y. Liu, C.C. DiRusso, P.N. Black, P.A. Watkins. Johns Hopkins University School of Medicine, Kennedy Krieger Institute, University of Nebraska Lincoln. B487 781.18 Charecterization of a Glycerophosphocholine Acyltransferase (Gpc1), a Novel Enzyme in Phosphatidylcholine Biosynthesis in Saccharomyces cerevisiae. S. Anaokar, I. Lager, B. Glab, A. Banas, S. Stymne, J. Patton-Vogt. Duquesne University, Swedish University of Agricultural Sciences, Sweden and Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Poland.
MONDAY BIOCHEMISTRY B488 781.19 Four Acyltransferases Uniquely Contribute to Phospholipid Heterogeneity in Saccharomyces cerevisiae. P. Oelkers, K. Pokhrel. University of Michigan-Dearborn. B489 781.20 The Malonyl-CoA:ACP Transacylase R117A Variant Catalyzes Acyl-Transfer with a Broad Range of Acyl-CoA Substrates. A.M. Marcella, A.W. Barb. Iowa State University. B490 781.21 Crystal Structure of LCAT Bound to a Small Molecule Allosteric Activator Reveals Its Active Conformation. K.A. Manthei, S.Yang, L. Chang, L.A. Freeman, B. Baljinnyam, M. Shen, D.J. Maloney, A.T. Remaley, A. Jadhav, J.J. Tesmer. University of Michigan and National Institutes of Health. B491 781.22 LplT-Aas System: The Primary Mechanism for Lysophospholipid Remodeling in E. coli. L. Zheng, Y. Lin, S. Tong, Z. Guan, M. Bogdanov. University of Texas Houston Medical School and Duke University. B492 781.23 Effect of Myeloid Specific ACAT1 Knockout on Atherosclerosis. J.A. Benson, E. Melton, L. Huang, P. Sohn, H. Li, C. Chang, T. Chang. Dartmouth College and Geisel School of Medicine.
782. REGULATION OF LIPID METABOLISM Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B493 782.1 Acyl-CoA Thioesterase 1 Regulates Hepatic Lipid Metabolism and PPAR-α Signaling. M.P. Franklin, A. Sathyanarayan, D. Mashek. University of Minnesota. B494 782.2 Phosphorylation of the Nem1-Spo7/Pah1 Phosphatase Cascade by Pkc1 Protein Kinase C. P. Dey, W. Su, G.M. Carman. Rutgers University. B495 782.3 Unravelling a Role of LRPPRC in Peroxisomal Lipid Metabolism Through Lipidomic Investigations in Human and Mouse. M. Ruiz, A. Cuillerier, F. Dupuis, P. Morue, B. Bouchard, I. Robillard-Frayne, A. Forest, C. Daneault, J. Thompson Legault, L. Coderre, Y. Burelle, J. Rioux, C. Des Rosiers. Montreal Heart Institute, Canada and Faculty of Health Sciences, Canada. B496 782.4 Regulation of Phosphatidic Acid Phosphatase by High Glucose in the Oleaginous Yeast Yarrowia lipolytica. D. Hardman, S. Fakas. Alabama A&M University. B497 782.5 XBP-1: A Key Transcriptional Regulator of Lipid Synthesis in Renal Epithelial Cells. M. Fernandez, M. Fernandez, R. Malvicini, K. Weber, L. Parra, L. Lepera, C. Casali. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, BCM, Argentina, CONICET, Argentina, Administración Nacional de Medicamentos and Alimentos y Tecnología Médica (ANMAT), Argentina.
B498 782.6 Methionine Restriction Decreases Fat Mass in C57BL/6 Mice via Increasing Endogenous Hydrogen Sulfide Production. Y. Wang, J. Zhang, H. Guo, B. Yan, Y. Shi, G. Le. Food Nutrition and Functional Factors Research Center, People’s Republic of China, Food Nutrition and Functional Factors Research Center, People’s Republic of China, The Laboratory of Food Nutrition and Functional Factors, People’s Republic of China. B499 782.7 Angiopoietin-Like 4 Directs Uptake of Dietary Fat Away from Adipose During Fasting. E.M. Cushing, B. Davies. University of Iowa. B500 782.8 Functional Interplay Between LXR and AMPKα inhibits Atherosclerosis in apoE-Deficient Mice—A New AntiAtherogenic Strategy. C. Ma, W. Zhang, Y. Duan, Y. Chen, J. Han. Nankai University, People’s Republic of China. B501 782.9 ANGPTL8 Promotes the Ability of nNGPTL3 to Inhibit Lipoprotein Lipase. B.S. Davies, X. Chi, E.C. Britt, H.W. Shows, A.J. Hjelmaas, S.K. Shetty, E.M. Cushing, R. Zhang. University of Iowa and Wayne State University. B502 782.10 Energy Substrate Levels and Metabolic Changes in Skeletal Muscle Underlie Increased Activity and Improved Exercise Performance in Liver Fatty Acid-Binding Protein Null Mice. H. Xu, A. Gajda, Y. Zhou, A. Fatima, J. Storch. Rutgers University. B503 782.11 Lantibiotic Synthetase C-Like Protein 2 (LanCL2) Is Necessary for 3T3-L1 Differentiation to Adipocytes. D. Dutta, J. Chen, W. van der Donk. University of Illinois and Urbana Champaign. B504 782.12 N-Terminal Phosphorylation of Thioesterase Superfamily Member 1 (Them1) Regulates Its Subcellular Localization in Brown Adipocytes. Y. Li, L. Ang, S.J. Hagen, D.E. Cohen. Beth Israel Deaconess Medical Center and Weill Cornell Medical College. B505 782.13 Tl(I) and Tl(III) Induce Alterations in MDCK Cell Lipid Metabolism. E. Morel Gomez, S. Verstraeten, M. Fernandez. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Argentina, CONICET, Argentina, Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica and BCM, Argentina. B506 782.14 A Severe Inherited Arrhythmia Syndrome Highlights the Role of Fatty Acid Metabolism in the Regulation of Cardiac Electrical Activity. R. Gelinas, P. Goyette, A. Forest, B. Bouchard, I. Robillard Frayne, L. Pruneau, M. Ruiz, L. Villeneuve, J. Thompson-Legault, M. Talajic, C. Des Rosiers, J.D. Rioux. Montreal Heart Institute, Canada and Université de Montréal, Canada. B507 782.15 Nutrient Sensing and Mitochondrial Coenzyme Q Biosynthesis: Are They Connected by a Phosphatase? A.M. Awad, S. Venkataramanan, A. Nag, M.C. Bradley, A.R. Galivanche, T.L. Johnson, C.F. Clarke. UCLA.
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BIOCHEMISTRY MONDAY B508 782.16 Regulation of Schizosaccharomyces pombe Lipid Homeostasis in Response to Low Oxygen by Coordinated Activation of the Transcription Factors Sre1 and Mga2. R. Burr, E.V. Stewart, W. Shao, S. Zhao, H.K. Hannibal-Bach, C.S. Ejsing, P.J. Espenshade. Johns Hopkins University School of Medicine, VILLUM Center for Bioanalytical Sciences and University of Southern Denmark, Denmark. B509 782.17 Macrophage Catabolism of Aggregated Lipoproteins Using a Novel Extracellular Compartment Regulates Lipid Accumulation During Atherosclerosis. R.K. Singh, A.S. Haka, V.C. Barbosa-Lorenzi, A. Asmal, F. Lund, Y. Xiong, H.F. Chin, I. Grosheva, T. Hla, F.R. Maxfield. Weill Cornell Medical College. B510 782.18 Novel Function of Tetraspanin-Interacting Protein IGSF3 in the Regulation of Glycosphingolipid Metabolism. K. Schweitzer, M.J. Justice, I. Bronova, S.M. Leach, E.V. Berdyshev, I. Petrache. National Jewish Health and Indiana University. B511 782.19 Rottlerin Diminished the Lipid Accumulation in 3T3-L1 Cell Line and Enhanced the Uncoupling of Oxidative Phosphorylation in D16 Cell Line via LRP6 Mediated Pathway. Y. Ryu, J. Jeong, G. Go. Kookmin University, Republic of Korea. B512 782.20 Insights Into the Cellular Trafficking of Perilipin 5. H.M. Bailey, J.T. Tansey. Otterbein University. B513 782.21 Detection of a Perilipin-5 Splice Variant. B. Ranzau, D.M. Dubreuil, T. Hubbell, J.T. Tansey. Otterbein University.
783. VESICLE TRAFFICKING AND CARGO Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B514 783.1 Scavenger Receptor BI Mediates the Uptake and Transcytosis of HDL in Brain Microvascular Endothelial Cells Independent of PDZK1 and Nitric Oxide. K.Y. Fung, C. Wang, S. Nyegaard, B. Heit, G. Fairn, W. Lee. St. Michael’s Hospital, Canada, Hospital for Sick Children, Canada and Western University, Canada. B515 783.2 Mapping the Atg9 Binding Site on Atg11, a Central Organizer of the Selective Autophagy Initiation Complex. M. Meyer, J. Winzeler, D. Sheppard, S.K. Backues. Eastern Michigan University.
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B516 783.3 The Effect of Cellular Autophagy on Replication and Dissemination of Theiler’s Murine Encephalomyelitis Virus. L. Benner. University of Tampa. B517 783.4 Multifaceted Role of Glycan Interactions on Clathrin-Independent Endocytosis of MHC1 and CD59. M.P. Mathew, J.G. Donaldson. National Heart Lung and Blood Institute. B518 783.5 Designed Proteins Induce Formation of Nanocage-Containing Vesicles. J. Votteler, C. Ogohara, S. Yi, Y. Hsia, U. Nattermann, D.M. Belnap, N.P. King, W.I. Sundquist. University of Utah and University of Washington. B519 783.6 Investigating the Effects of Vps45 Mutations Associated with Severe Congenital Neutropenia on SNARE Interactions. A. D’Ordine, P.E. Newburger, M. Munson. UMass Medical School. B520 783.7 Structural and Functional Studies of the ANTH Domain as Ubiquitin–Binding Module Involved in Endocytosis. N. Pashkova, R.C. Piper. University of Iowa. B521 783.8 The Selective Autophagy Pathway of Nanodiamond-SSEA-1 Antibody in GBM Cells. C. Ting-Hua. National Chiao Tung University, Taiwan. B522 783.9 Regulation of Angiotensin Receptor Trafficking by an Upstream Short Open Reading Frame in the mRNA 5’ Leader Sequence. P. Kadam, S. Mueller, H. Ji, K. Sandberg. Georgetown University. B523 783.10 Use of the Auxin-Induced Degradation System to Dissect Factors Important for Exocyst Assembly and Localization. R.D. Heard, D. Lepore, M. Munson. University of Massachusetts Medical School. B524 783.11 Genetic Dissection of Early Endosomal Recycling Highlights a TORC1-Independent Role for Rag GTPases. C. MacDonald, R.C. Piper. University of Iowa. B525 783.12 Myopalladin’s Role in Cardiac Muscle Function and Disease. V.K. Kadarla, B.M. Bigge, M.R. Beck. Wichita State University. B526 783.13 The Effect of Intermolecular Interactions in the Elongation Rates of Actin Filament by Formins. F. Aydin, N. Courtemanche, T.D. Pollard, G.A. Voth. University of Chicago, University of Minnesota and Yale University. B527 783.14 Cytoskeleton-Associated Protein 4 (CKAP4) Knockdown Disrupts the Actin Filament Network in Bladder Carcinoma Cells. T. Majernick, B. Chavda, S.L. Planey. The Commonwealth Medical College.
MONDAY BIOCHEMISTRY
784. GLYCANS AND GLYCOBIOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B528 784.1 Glycosylation Quality Control by the Golgi Structure. Y. Wang, S. Huang, Y. Haga, H.K. Kweon, H. Hirayama, P. Andrews, T. Suzuki. University of Michigan and RIKEN, Japan. B529 784.2 Methodology Toward the Purification and Analysis of Glycopolymers. G. Nagy, T. Peng, N.L. Pohl. Indiana University. B530 784.3 Toward a Glycosidase Toolbox for Glycan Structure Analysis: General Label-Free Mass SpectrometryBased Assay to Identify Glycosidase Substrate Competence. T. Peng, G. Nagy, N.L. Pohl. Indiana University. B531 784.4 Microbiota-Sensing O-GlcNAc Signaling in Intestinal and Metabolic Homeostasis. H. Ruan, M. Zhao. University of Minnesota. B532 784.5 The Expanding Glycouniverse: Diverse Glycan Modifications in Lower Eukaryotes. I.B. Wilson, S. Yan, A. Hykollari, B. Eckmair, J. Vanbeselaere, K. Paschinger. Universitaet fuer Bodenkultur Wien, Austria. B533 784.6 Glycoproteins in the Midgut Microvilar Membrane of Spodoptera frugiperda (Lepidoptera: Noctuidae). F.J. Fuzita, K.B. Chandler, J.R. Haserick, C. Ferreira, W.R. Terra, C.E. Costello. University of Sao Paulo, Brazil and Boston University. B534 784.7 Imaging Specific Glycan Epitopes on Cells Using Glycosyltransferases via Click Chemistry. Z.L. Wu, A. Person, M. Anderson, B. Burroughs, R. Sackstein, T. Geders. Bio-techne, Brigham & Women’s Hospital and Harvard Medical School. B535 784.8 The Human Lectin Galectin-3 Recognizes Chondroitin Sulfate Proteoglycans (CSPGs) and Sulfated Glycosaminoglycans. T. Dam, M. Talaga, N. Fan, A. Fueri, R. Brown, P. Bandyopadhyay. Michigan Technological University. B536 784.9 Using Recombined RNA Aptamers to Specifically Change O-Glcnacylation on a Protein. Y. Zhu. Johns Hopkins University.
B537 784.10 Toward Facile Automated Glycan Synthesis: Current Progress and Remaining Challenges. N.L. Pohl. Indiana University. B538 784.11 Examining the Role of the AMP-Activated Protein Kinase in Stress-Dependent O-GlcNAc Signaling. A. Maduka, K. Fahie, N. Zachara. University of Maryland, Baltimore County and Johns Hopkins University School of Medicine. B539 784.12 Differing O-Glycan-Forming Glycosyltransferase Expression Profiles in Cancer Cells Act as Signatures That Accurately Identify Cancer Types/ Subtypes, Epithelial-Mesenchymal Transforming Cells as Well as Cancer Stem Cells. A.F. Abuelela, J.S. Merzaban. KAUST, Saudi Arabia.
785. GLYCAN FUNCTION AND CONTROL MECHANISMS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B540 785.1 Analysis of C-Mannosylated Proteins, Hsc70, and Inflammation. D.A. Seccurro, J. Rakus. Marshall University. B541 785.2 Identifying C-Mannosylated Peptides Involved in Hsc70 Mediated Inflammation. N.R. Kegley. Marshall University. B542 785.3 Metabolic Modulation of Cell Surface Sialoform of Macrophages. Y. Zhao. Cleveland State University. B543 785.4 The Tumor Associated Lectin Galectin-3 Can Bind and Sequester Cancer Biomarkers. N. Fan, M. Talaga, R. Brown, A. Fueri, P. Bandyopadhyay, T. Dam. Michigan Technological University. B544 785.5 Enhanced Glycosylation Detection and Characterization of a Human IgG1 Reference Material by Using 2D-LC MS/MS Fractionation and High Resolution Mass Spectral Library. Q. Dong, X. Yan, Y. Liang, S.E. Stein. NIST.
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Nutrition 786. GLOBAL NUTRITION II Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C1 I 786.1 Newly Developed In-House ELISA Methods for Measuring Serum Ferritin, Soluble Transferrin Receptor, C-Reactive Protein and Alpha-1-Acid Glycoprotein. R. Esmaeili, M. Zhang, C. Mapango, C.M. Pfeiffer. Centers for Disease Control and Prevention. C2 II 786.2 Blood Lead Toxicity Is Not Associated with Anemia and Iron Deficiency in Children from Bhaktapur, Nepal. R.K. Chandyo, B. Shrestha, B. Zhao, M. Ulak, P.S. Shrestha, R. Shrestha, L. Bodhidatta, C. Mason, L. Shrestha, T. Strand, S. Shrestha. Child Health Research Project, Institute of Medicine, TU, Nepal, Walter Reed/Armed Forces Research Institute of Medical Sciences, Research Unit, Kathmandu, Nepal, Nepal, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Department of Biostatistics, Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand, Thailand, Centre for Intervention Science in Maternal and Child Health, University of Bergen and Norway, Norway. C3 I 786.3 A Simplified Red Blood Cell Folate Calculation: Comparison to the Traditional Calculation Using Data from NHANES 2007–2010. M. Zhang, M.R. Sternberg, C.M. Pfeiffer. Centers for Disease Control and Prevention. C4 II 786.4 Zinc (Zn) Absorption from Micronutrient Powders (MNP) Is Low in Bangladeshi Toddlers with Environmental Enteric Dysfunction (EED). N.F. Krebs, J. Long, P. Mondal, J. Westcott, L. Miller, M. Islam, M. Ahmed, M. Mahfuz, T. Ahmed. University of Colorado School of Medicine, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Bangladesh. C5 I 786.5 Iodine Status and Its Determinants Among Adolescent School Girls in Rural Tanzania. S.M. Bakar, K. Lee, W. Song. Michigan State University. C6 II 786.6 Integrated DHS and National Micronutrient Survey: A Case Study from Malawi. E. Rhodes, K. Tripp, G. Mshali, E. Nyirenda, P. Suchdev. Emory University, Centers for Disease Control and Prevention and National Statistical Office of Malawi, Malawi. C7 I 786.7 Iron Content in Groundwater Associated with Anemia Among Children 6–37 Months in Rural Bangladesh. A.S. Wendt, J.L. Waid, S. Gabrysch. University of Heidelberg, Germany and Helen Keller International, Bangladesh. C8 II 786.8 Effects of Preconceptional Weekly Micronutrient Supplements on Maternal and Child Anemia During the First 2 Years of Life. P. Nguyen, M. Young, I. Gonzalez-Casanova, T.V. Truong, S. Nguyen, R. Martorell, U. Ramakrishnan. International Food Policy Research Institute, Thai Nguyen University of Pharmacy and Medicine, Vietnam and Emory University.
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C9 I 786.9 Impact of Dosing Regimen on Consumption of Calcium Supplements for Prevention of Preeclampsia Among Antenatal Care Clients: A ClusterRandomized, Non-Inferiority Trial in Western Kenya. M.O. Omotayo, K. Dickin, D.L. Pelletier, E. Mwanga, J. Kung’u, R. Stoltzfus. State University of New York at Buffalo, Cornell University, Malava Subcounty, Kakamega County, Kenya and The Micronutrient Initiative, Kenya. C10 II 786.10 Pattern of Urinary Sodium Excretion Following Consumption of a Known Quantity of Sodium. A.J. Lobene, B.R. Martin, C.J. Macdonald-Clarke, C.A. Anderson, L.D. McCabe, G.P. McCabe, C.M. Weaver. Purdue University, Liverpool Hope University, United Kingdom and UC San Diego School of Medicine. C11 I 786.11 Suboptimal Thiamin Status Is Common Among Women of Reproductive Age and Children ≤5 y in Cambodia: Findings from the National Micronutrient Survey. K.C. Whitfield, G. Smith, C. Chamnan, C.D. Karakochuk, K. Kuong, M.A. Dijkhuizen, R. Hong, J. Berger, T.J. Green, F.T. Wieringa. Mount Saint Vincent University, Canada, International Life Sciences Institute (Southeast Asia Region), Singapore, Essential Micronutrients Foundation, Singapore, Fisheries Administration, Ministry of Agriculture, Forestry and Fisheries, Cambodia, University of British Columbia, Canada, Copenhagen University, Denmark, ICF, Institute of Research for Development, France, South Australian Health and Medical Research Institute, Australia and University of Adelaide, Australia. C12 II 786.12 Vitamin D Status and the Menstrual Cycle: A Systematic Review. A. Subramanian, A.D. Gernand. Department of Nutritional Sciences and The Pennsylvania State University. C13 I 786.13 Iron Bioavailability from Moringa oleifera Leaves Is Very Low. D.D. Gallaher, C.M. Gallaher, S. Natukunda, T.C. Schoenfuss, E. Mupere, S.E. Cusick. University of Minnesota and Makerere University, Uganda. C14 II 786.14 Iron-Fortified Spiced Vinegar “Suka”: A Novel Approach to Address Iron Deficiency in the Philippines. E.C. Lopez, S. Gaur, N.J. Engeseth, C. Nielsen, W.G. Helferich. University of Illinois at Urbana Champaign and University of Baltimore. C15 I 786.15 New Formulations for Fortified-Blended Foods: The MFFAPP Tanzania Efficacy Trial. N.M. Delimont, S. Alavi, B. Lindshield. Kansas State University. C16 II 786.16 Prevalence of Anemia Is Significantly Higher in Six Month Old Infants Than in Their Mothers in Southern Ethiopia. T. Gebreeziabher, B.J. Stoecker. Central Washington University and Oklahoma State University. C17 I 786.17 Withdrawn. C18 II 786.18 Screening of Dried Matrix Spot Collection Devices to Be Used for Nutritional Biomarker Analysis. F.X. Arredondo, N.E. Craft. Craft Technologies and Inc. C19 I 786.19 Prevalence and Risk Factors for Infantile Bleeding and Mortality in Rural Bangladesh: Is Vitamin K Deficiency a Cause? A.L. Thorne-Lyman, M. Rashid, L. Wu, K. Schulze, P. Christian, A.B. Labrique, H. Ali, S. Mehra, S. Shaikh, R.D. Klemm, K.P. West Jr. Johns Hopkins Bloomberg School of Public Health, Harvard T.H. Chan School of Public Health, JiVitA Project, Bangladesh, Bill & Melinda Gates Foundation and Helen Keller International.
MONDAY NUTRITION C20 II 786.20 Micronutrient Deficiencies in Ghanaian Women Before Pregnancy. A.D. Gernand, S. Aguree, R. Pobee, L.E. Murray-Kolb. The Pennsylvania State University. C21 I 786.21 Pregestational Obesity May Have an Indirect Effect on Iron Status During Pregnancy Considering the Increase of Gestational Weight. M. Flores-Quijano, M. López-Alarcón, C. Muñoz-Manrique, M. Tolentino-Dolores. Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico, Pediatric Hospital “Centro Médico Nacional Siglo XXI” and Mexican Institute of Social Security, Mexico. C22 II 786.22 Correspondence of 25-Hepcidin Concentrations by ELISA and Mass Spectrometric Methods and Their Discrimination Across Healthy and Ill Subject Groups. M. Orozco, C.L. Arriaga, N.W. Solomons, K. Schümann. CeSSIAM, Guatemala and Hildegard Grunow Foundation, Germany. C23 I 786.23 Inflammation During Pregnancy and Growth of Early School-Aged Children in Rural Nepal. A.A. Panjwani, K. Schulze, L. Wu, K.P. West Jr., P. Christian. Johns Hopkins University Bloomberg School of Public Health. C24 II 786.24 Risk Factors for M. tuberculosis Infection in Vitamin D Deficient Mongolian School Children. D. Ganmaa, P. Khudyakov, O. Munkhjargal, B. Jargalsaikhan, D. Baigal, B. Ochirbat, U. Buyanjargal, A. Martineau. Harvard T.H. Chan School of Public Health, Brigham and Women’s Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Mongolian Health Initiative, Mongolia and Queen Mary University of London, United Kingdom. C25 I 786.25 Lipid-Based Nutrient Supplement 2.0: Encapsulation of Oregano Essential Oil to Address Intestinal Parasitic Infections in Indian Children. S. Gaur, E. Lopez, A. Ojha, D. Shukla, P.R. Patel, J.E. Andrade. University of Illinois, Urbana-Champaign, National Institute of Food Technology and Entrepreneurship and Management, India and Mansinhbhai Institute of Dairy and Food Technology, India. C26 II 786.26 Regulation of Inflammation Metabolism of Hibiscus manihot L. Water Extract. K. Kim, M. Choe. Kangwon National University, Republic of Korea, Well-Being Bioproducts R&D Regional Innovation Center, Republic of Korea. C27 I 786.27 Effect of DM Extracts on the Atopy Dermatitis in Human Keratinocytes. H. Kim, M. Lee, H. Kwon, S. Park, D. Lee, Y.J. Kim, E. Kim, J. Lee. Kyung Hee University, Republic of Korea, Hambakjae Bio Farm Co., Ltd., Republic of Korea, Hambakjae Bio Farm Co., Ltd., Research Institute, Republic of Korea, Research Institute of Medical Nutrition, Republic of Korea. C28 II 786.28 Fractionated Dairy Cow Milk β-Casein Modulates Jejunal Alkaline Phosphatase Activity Kinetics in Neonatal Piglets Liquid Formulas. N.A. Burello, N. Tari, K. Zhou, T. Archbold, M. Corredig, M.Z. Fan. University of Guelph, Canada. C29 I 786.29 MODE-K Cells as a Model to Study the Gut Epithelial Response: An Outside-In and Inside-Out Approach. E.K. Crockett, K.F. Washburn, J.L. Graef, E.A. Lucas, B.J. Smith. Oklahoma State University and University of Oklahoma Health Sciences Center. C30 II 786.30 Prolonged Fasting Increases the Cholesterol Efflux Capacity and Anti-Inflammatory Functionality of HDL Particles in Human Subjects. C.H. Rhodes. UC Davis.
C31 I 786.31 Knowledge and Attitudes of Mothers and Health Providers Toward Home-Complementation with Micronutrients in Baja Verapaz, Guatemala. R. GarcíaMeza, W. González, A. Tumilowicz, N.W. Solomons. CeSSIAM, Guatemala and Global Alliance for Improved Nutrition, Switzerland. C32 II 786.32 Incorporating Calcium Supplementation Into Antenatal Care Services Is Acceptable to Providers, Pregnant Women, and Families in Western Kenya. S. Martin, V. Wawire, T. Li, K. Sklar, H. Tzehaie, A. Wong, H. Ombunda, M. Omotayo, G. Chapleau, R. Stoltzfus, K. Dickin. Cornell University, Kenyatta University, Kenya and University at Buffalo. C33 I 786.33 Prenatal Food and Micronutrient Interventions in Rural Bangladesh Remain Cost-Effective When Assessing Both Favorable and Unfavorable Outcomes: Cost-Effectiveness Analysis of the Minimat Trial on Under FiveMortality and Stunting. P. Svefors, K. Ekholm Selling, R.E. Shaheen, L.E. Persson, L. Lindholm. Uppsala University, Sweden and Umeå University, Sweden. C34 II 786.34 A Program Impact Pathways Mediation Analysis of a Multi-Sectoral Nutrition Program in Nepal. J. Choufani, A. Kennedy, P. Pandey, K. Cunningham. London School of Hygiene and Tropical Medicine, United Kingdom, Helen Keller International (HKI), Nepal and Suaahara/Helen Keller International (HKI), United Kingdom. C35 I 786.35 Effects of Early Prenatal Food Supplementation and Multiple Micronutrients on Under-Five Survival, Linear Growth, Metabolic Markers and Blood Pressure Up to 10 Years of Age. The Minimat Trial in Rural Bangladesh. L.Å. Persson, S.E. Arifeen, A. Khan, A. Rahman, E. Ekström. Uppsala University, Sweden, London School of Hygiene & Tropical Medicine, United Kingdom, icddr,b, Bangladesh. C36 II 786.36 Content Validity of the Abbreviated Women’s Empowerment in Agriculture Index (A-WEAI) in Ethiopia: A Mixed Methods Approach. M. Min-Barron, J. Coates, S. Ghosh, B. Rogers, J. Maluccio. Friedman School of Nutrition Science and Policy-Tufts University and Middlebury College. C37 I 786.37 Feasibility of Integrating Calcium and Iron-Folic Acid Supplementation to Prevent Preeclampsia and Anemia in Pregnancy in Primary Healthcare Facilities in Kenya. M.O. Omotayo, K. Dickin, D. Pelletier, S. Martin, J. Kung’u, R. Stoltzfus. State University of New York at Buffalo, Cornell University and The Micronutrient Initiative, Kenya. C38 II 786.38 Facilitators and Barriers to Access and Utilization of a Comprehensive Nutrition Program in Rural Malawi—A Qualitative Study. J.C. Ruel-Bergeron, R. Oemcke, N. Kapadia-Kundu, K. Hurley, P. Christian. Johns Hopkins University, JHU Center for Communication Programs and Bill & Melinda Gates Foundation. C39 I 786.39 A Nutrition Education Intervention Affects the Diet-Health Related Practices and Nutritional Status of Mothers and Children in a Pulse-Growing Community in Halaba, South Ethiopia. G. Ersino, C.J. Henry, G. Zello. College of Pharmacy & Nutrition, University of Saskatchewan, Canada and Hawassa University, Ethiopia. C40 II 786.40 Association of Antenatal Care Visit with Breastfeeding Practices Depends on Maternal Education in Ethiopia. S. Basnet, E.A. Frongillo, M. Girma. University of South Carolina and Micronutrient Initiative, Ethiopia.
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NUTRITION MONDAY C41 I 786.41 Evaluation of a Social Network for Improved Child Nutrition. K.J. Fiorella, M. Moore, F. WilsonAnumudu, A. Argent, E. Gavenus, E.M. Milner, D. Omollo, L. Fernald. Cornell University, University of California, San Francisco, University of California, Berkeley, University of Arizona and Organic Health Response-Ekialo Kiona Center, Kenya. C42 II 786.42 Acceptability and Feasibility of Multiple Micronutrient Powders vs. Iron Syrup in Young Children in Bihar, India. M.F. Young, A. Webb Girard, R. Mehta, S. Srikantiah, P. Menon, U. Ramakrishnan, R. Martorell, R. Avula. Emory University, CARE India, India and International Food Policy Research Institute, India. C43 I 786.43 Dietary and Water, Sanitation, and Hygiene Patterns in Children 6–23 Months of Age Participating in a Feeding and Behavioral Change Communications Program in Rural Malawi. J.C. Ruel-Bergeron, K. Hurley, A. Bou Monclus, Y. Kang, L. Shu Fune Wu, M. Mitra, J. Phuka, R. Klemm, K. West, P. Christian. Johns Hopkins University, University of Malawi, Malawi, Hellen Keller International and Bill & Melinda Gates Foundation. C44 II 786.44 Effect of Early Market Introduction of Iodized Salt on Pregnancy and Birth Outcomes in a Randomized Clinical Trial in the Amhara Region of Ethiopia. H. Mohammed, G. Marquis, F. Aboud, K. Bougma, K.B. Harding, A. Samuel. McGill University, Canada, Micronutrient Initiative, Canada and Ethiopian Public Health Institute, Ethiopia. C45 I 786.45 Homestead Food Production and Child Anemia in Burkina Faso: The Mediating Roles of Mother’s Knowledge and Production of Micronutrient-Rich Fruits and Vegetables. A. Kennedy, S. Kadiyala, R. Daniel, N. Poole, D. Olney. London School of Hygiene & Tropical Medicine, United Kingdom, SOAS University of London, United Kingdom and International Food Policy Research Institute. C46 II 786.46 Nutrition in Transition: Building Clinical Nutrition Capacity to Train Dietitians in Lao PDR. J. Cummings, D. Stadler. Oregon Health & Science University. C47 I 786.47 Integrating Nutrition-Focused Behavior Change Communication and Community Mobilization Into Existing Maternal, Neonatal and Child Health Platform Improved Consumption of Diversified Foods and Micronutrients and Exclusive Breastfeeding Practices in Bangladesh: Results of a Cluster-Randomized Program Evaluation. P. Nguyen, T. Sanghvi, Z. Mahmud, L. Tran, S. Shabnam, B. Aktar, K. Afsana, E. Frongillo, M. Ruel, P. Menon. International Food Policy Research Institute, FHI360, BRAC, Bangladesh and University of South Carolina. C48 II 786.48 Irrigation’s Potential to Improve Dietary Diversity, Production Diversity and Income in Sub-Saharan Africa: Evidence from Ethiopia and Tanzania. S.A. Passarelli, E. Bryan, D. Mekonnen. Harvard University and International Food Policy Research Institute. C49 I 786.49 Understanding the Effect of CommunityBased Health and Nutrition Program on Uptake of Iron and Folic Acid Supplementation and Breastfeeding Practices in a Pastoralist Community in Rural Ethiopia. S. Kulkarni, E.A. Frongillo, M. Girma. University of South Carolina and Micronutrient Initiative, Ethiopia. C50 II 786.50 Hungry for Information: Empowerment and Food Security in Honduran Extension Programs. E.M. Sloffer, C. Buckley, J.E. Andrade. University of Illinois and Urbana-Champaign.
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C51 I 786.51 An Integrated Approach to Harmonize Nutrition Knowledge Across Sectors in the Upper Manya Krobo District of Ghana. K. Birks, G. Marquis, S. Matey, R. Owusu, B. Aidam, R. Aryeetey, T. Thompson-Colón. McGill University, Canada, World Vision, Ghana, World Vision and University of Ghana, Ghana. C52 II 786.52 Nutrition Knowledge, Attitudes, and Practices Among Employees of Organizations That Provide Agricultural Extension Services and Their Beneficiaries in Rural Honduras. J.L. Lotton, A.L. Scherer, E.M. Sloffer, K.R. McNamara, J.M. Andrade, J.E. Andrade. University of Illinois, Urbana-Champaign, University of Florida, Gainsville and Eastern Illinois University. C53 I 786.53 The Role of Good Governance and an Enabling Environment in Delivering Good Nutrition. E.T. Kennedy. Tufts University. C54 II 786.54 Determinants of Maternal and Child Malnutrition Among Low Income Households in Turkana County, Kenya. T. Mbogori, M. Murimi. Ball State University and Texas Tech University. C55 I 786.55 Costing Methods for a ClusterRandomized Cost-Effectiveness Trial Comparing the Performance of Four Supplementary Foods in Treating Sierra Leonean Children with Moderate Acute Malnutrition (MAM). Y.K. Shen, S. Griswold, D. Suri, S.A. Vosti, B. Rogers. Tufts University and University of California-Davis. C56 II 786.56 Getting the Food List “Right”: Leveraging Household Consumption and Expenditure Surveys for Food Security and Nutrition. J. Coates, W.F. Bell, O.I. Bermudez, B.L. Rogers. Tufts University Friedman School of Nutrition Science and Policy and Tufts University School of Medicine.
787. PUBLIC POLICY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C57 I 787.1 Variation in Nutritional Quality of School Lunches with Implementation of National School Lunch Program Guidelines. J. Joyce, S. Rosenkranz. Kansas State University. C58 II 787.2 NIH Nutrition Research Funding, Fiscal Years 2012–2016. K.S. Regan, R. Fisher. National Institutes of Health. C59 I 787.3 Assessing the Reach of Myplate in the U.S. Population: An Analysis Using NHANES Data. R. Raghavan, T. Schap, J. Haven, A. Tagtow. USDA/CNPP and Johns Hopkins Blooomberg School of Public Health. C60 II 787.4 Impacts on Student Fruit and Vegetable Consumption and Snack Participation in the Canned, Frozen, and Dried Pilot Project of the Fresh Fruit and Vegetable Program (FFVP). K. Niland, A. Gothro, J. Cannon, M. Crepinsek, L. Washburn, M. Melia, A. Magness, R. Briefel. Mathematica Policy Research, USDA and FNS. C61 I 787.5 A New Tool for Researchers: The USDA Branded Food Products Database. D.B. Haytowitz, P.R. Pehrsson, K.A. McKillop, G. Moore, J. Finley, N.K. Fukagawa. USDA-ARS, University of Maryland and USDAARS-National Agricultural Library.
MONDAY NUTRITION C62 II 787.6 How to Make Kids Eat Healthier in School Cafeterias: An Evidence from Smarter Lunchrooms Program in North East U.S. D.R. Just, B. Wansink, G. Gabrielyan, A.S. Hanks, A. Brumberg. Cornell University and Ohio State University.
788. EPIDEMIOLOGICAL RESEARCH ADDRESSING DIET AND HEALTH OUTCOMES Poster (Sponsored by: Nutritional Epidemiology RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C63 I 788.1 Time-of-Day Macronutrient Intake and Blood Pressure Levels: The Nutrition and Health Survey in Taiwan. H-J. Chen, W. Pan. National Yang-Ming University, Taiwan and Academia Sinica, Taiwan. C64 II 788.2 Consumers of Frozen Fruits and Vegetables Eat More Fruits and Vegetables Overall. M. Storey, P. Anderson. Maureen Storey, LLC and Consultant. C65 I 788.3 Dietary and Lifestyle Determinants of Vitamin D Status in Filipino Women Living in Korea: FiLWHEL Study. S. Kim, G. Abris, S. Provido, W. Shin, S. Hong, S. Yu, C. Lee, J. Lee. Sookmyung Women’s University, Republic of Korea, Seoul National University, Republic of Korea, Hallym University Dongtan Sacred Heart Hospital, Republic of Korea, Hanyang University School of Medicine, and Republic of Korea. C66 II 788.4 Prevalence of Low-Calorie Sweetener Intake in South Asian Adults. Y. Jin, A.C. Sylvetsky, N. Kandula, A.M. Kanaya, S.A. Talegawkar. George Washington University Milken Institute School of Public Health, Summer M. Redstone Global Center for Prevention and Wellness, Milken Institute School of Public Health, The George Washington University, Division of General Internal Medicine, Northwestern University, Division of General Internal Medicine, University of California at San Francisco. C67 I 788.5 A Minimally Processed Dietary Pattern Is Associated with Lower Odds of Metabolic Syndrome Among Lebanese Adults. L. Nasreddine, H. Tamim, N. Hwalla, L. Itani, M. Nasrallah, H. Ismaeel, N. Nakhoul, J. Abou-Rizk, F. Naja. American University of Beirut, Lebanon, Beirut Arab University, Lebanon and University of Hohenheim, Germany. C68 II 788.6 Iron, Oxidative Stress, and StearoylCoa Desaturase Activity: An Analysis from the National Health and Nutrition Examination Survey 2003–04. Y. Wu, A. Baylin, J. Colacino. University of Michigan School of Public Health and University of Michigan Comprehensive Cancer Center. C69 I 788.7 Serum 25(OH)D Concentrations Are Associated with the Glycemic Status and Insulin Resistance Among Adults in Southwest China. D. Li, H. Xue, J. Zhang, G. Cheng. West China School of Public Health, Sichuan University, People’s Republic of China. C70 II 788.8 An Approach for Examining the Impact of Food Group-Based Sources of Nutrients on Outcomes with Application to PUFAs and LDL. J.A. Tooze, J.L. Crandell, N.S. The, S.C. Couch, E.J. Mayer-Davis, C. Koebnick, A.D. Liese. Wake Forest School of Medicine, University of North Carolina, Furman University, University of Cincinnati Medical Center, Kaiser Permanente and University of South Carolina.
C71 I 788.9 A Health Behaviour Score Is Associated with Hypertension and Obesity Among Australian Adults. K.M. Livingstone, S. McNaughton. Deakin University, Australia. C72 II 788.10 Dietary Patterns Derived by Reduced Rank Regression Are Associated with Cardiometabolic Disease. K.M. Livingstone, S. McNaughton. Deakin University, Australia. C73 I 788.11 Comparison of Self-Reported Weight Status Among Followers of Popular Diets: Data from the ADAPT (Adhering to Dietary Approaches for Personal Taste) Feasibility Survey. M.C. Karlsen, A.H. Lichtenstein, C.D. Economos, S.C. Folta, G. Rogers, P.F. Jacques, K.A. Livingston, N.M. McKeown. JM USDA HNRCA at Tufts University, Friedman School of Nutrition Science & Policy and Tufts University. C74 II 788.12 Consumption of Ultra-Processed Foods and Socioeconomic Position: Cross Sectional Analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). B.d. Simões, S.M. Barreto, M.B. Molina, V.C. Luft, B.B. Duncan, M.I. Schmidt, I.M. Benseñor, L.d. Cardoso, R.B. Levy, L. Giatti. Universidade Federal de Minas Gerais, Brazil, Universidade Federal do Espírito Santo, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Universidade de São Paulo, Brazil and FIOCRUZ, Brazil. C75 I 788.13 Web-Based Recruitment and Survey Methodology to Capture Followers of Popular Diets: The Adhering to Dietary Approaches for Personal Taste (ADAPT) Feasibility Survey. M.C. Karlsen, A.H. Lichtenstein, C.D. Economos, S.C. Folta, G. Rogers, P.F. Jacques, K.A. Livingston, K.M. Rancaño, N.M. McKeown. JM USDA HNRCA at Tufts University, Friedman School of Nutrition Science & Policy and Tufts University. C76 II 788.14 Consumption of Raisin-Containing Foods Is Associated with Increased Nutrient Intake and Better Diet Quality in Adult Participants (19+ y) from the NHANES (2001–2012). V.L. Fulgoni; III, J.E. Painter, A. Carughi. Nutrition Impact, LLC, Padre Blvd. and Sun-Maid Growers of California. C77 I 788.15 Dairy Consumption and Total and Cause-Specific Mortality in the Southern Community Cohort Study. Y. Takata, X. Shu, W. Zheng, W.J. Blot. Oregon State University, Vanderbilt University School of Medicine and International Epidemiology Institute. C78 II 788.16 Iodine Status and Food Sources of Iodine by Race-Hispanic Origin, NHANES 2011–2014. K. Herrick, C. Perrine. CDC, NCHS and CDC. C79 I 788.17 Higher Mediterranean Diet Quality Score and Lower BMI Are Associated with a Less Oxidized Plasma Glutathione and Cysteine Redox Status in Adults. E. Bettermann, T.J. Hartman, E.P. Ferranti, D.P. Jones, A.A. Quyyumi, V. Vaccarino, T.R. Ziegler, J.A. Alvarez. Emory University. C80 II 788.18 Impact of Food Fortification on Dietary Folate Intake and Adequacy in a Representative Sample of Urban Costa Rican Population: Results from the Latin American Study of Nutrition and Health (Elans). G. Gomez, A. Ramírez, A. Sheik, A. Chinnock, R. Monge. Universidad de Costa Rica, Costa Rica and Ministerio de Salud, Costa Rica. C81 I 788.19 Effect of Dietary Intake on Bone Mineral Density Among Non-Obese and Obese Women. P. Aggarwal, S.L. Volpe. Drexel University. C82 II 788.20 Healthcare Costs and Savings Associated with Increased Dairy Consumption in the United States. C. Scrafford, J.K. Schmier, M.M. Murphy, L.M. Barraj. Exponent and Inc.
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NUTRITION MONDAY C83 I 788.21 Association of Self-Reported Oat and Milk Consumption with Markers of Cardiovascular Disease. A. Olson, C.L. Frankenfeld, T.C. Wallace, J. Johnson. George Mason University, Think Healthy Group, LLC and PepsiCo. C84 II 788.22 Validation of Masimo Pronto 7 and Hemocue 201 for Hemoglobin Determination in Children from 1 to 5 Years of Age. I. Mendez Gomez Humaran, T. Shamah Levy, M. Morales Ruán, B. Martinez Tapia, S. Villalpando Hernández, M. Hernández Ávila. Center for Research in Mathematics, Mexico and National Public Health Institute, Mexico. C85 I 788.23 Frequency of 100% Fruit Juice Consumption by Canadians Is Associated with Higher Micronutrient Intake and Improved Nutrient Adequacy. M.M. Murphy, L.M. Barraj, T. Brisbois, A.M. Duncan. Exponent, Inc., PepsiCo and University of Guelph, Canada. C86 II 788.24 Association of Rates of Obesity with Voting Patterns in the 2016 Presidential Election. A. Krauss, A. Taetzsch, A. Maaliki, D. Mozaffarian, S.B. Roberts. Human Nutrition Research Center on Aging/ Tufts University and Tufts Friedman School of Nutrition Science & Policy. C87 I 788.25 Very Low-Level Metal Exposure, Dietary Intakes, and Oxidative Stress in Children from Montevideo, Uruguay. K. Kordas, A. Roy, J. Nie, M. Vahter, N. Mañay, G. Martinez, F. Peregalli, K. Kordas. University at Buffalo, Vanderbilt University Medical Center, Karolinska Institutet, Sweden, University of the Republic of Uruguay, Uruguay and Catholic University of Uruguay, Uruguay. C88 II 788.26 Sources of Dietary Folate/Folic Acid in Women of Different Races in the United States Between 2009 and 2012: What Is the Role of Fortified and Enriched Products? R. DeVirgiliis. Milken Institute School of Public Health and George Washington University. C89 I 788.27 Health and Wellness in the College Population: Dietary and Lifestyle Contributions to Bone Health. K. Plawecki, B. Beezhold, T. Chen, C. Cundari, H. Sabella. Benedictine University. C90 II 788.28 Trends in Consumption of Candy by the U.S. Population Between 1971 and 2012: Results from NHANES. L. Barraj, M.M. Murphy, L. Shumow. Exponent and National Confectioners Association. C91 I 788.29 Dietary Intakes of EPA and DHA Omega-3 Fatty Acids Among U.S. Pregnant Women. Z. Zhang, S. Mitmesser. The Nature’s Bounty Co. C92 II 788.30 The Role of Dietary Factors in Accumulation of Pericardial Adipose Tissue Volume in the Coronary Artery Calcification in Type 1 Diabetes Study. J. Moore, L. Pyle, A. Alman, J. Snell-Bergeon. Children’s Hospital Colorado/Barbara Davis Center for Childhood Diabetes, Colorado School of Public Health/University of Colorado School of Medicine, University of South Florida College of Public Health and Barbara Davis Center for Childhood Diabetes. C93 I 788.31 A Randomized Clinical Trial for the Effects of Rice-Based Korean Diet on Cardiovascular Risk Factors in Korean Adults. S. Kim, K. Ha, S. Ahn, D. Ham, S. Kim, H. Joung. Seoul National University, Republic of Korea, Institute of Health and Environment, Seoul National University, Republic of Korea.
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C94 II 788.32 Factors Associated with Anemia in Pregnant Women in Banke, Nepal. S. Ghosh, J. Andrews Trevino, D. Davis, R. Shrestha, A. Bhattarai, A. KC, A. Pokharel, B. Dulal, S. Gurung, K. Paudel, K. Baral, P. Webb. Tufts, Helen Keller International, Nepal, Feed the Future Innovation Lab, Nepal, KANTI Children’s Hospital, Nepal and Patan Academy of Medical Sciences, Nepal. C95 I 788.33 Dietary Diversity in Mexican Adults from the 2016 National Nutrition Survey. S. Rodríguez-Ramírez, B. Martínez-Tapia, E.B. Gaona-Pineda, A. Arango-Angarita, T. Shamah-Levy. National Institute of Public Health, Mexico. C96 II 788.34 Omega-3 Polyunsaturated Fatty Acid Erythrocyte Composition and 2-Year Change in Body Weight. S.J. Bigornia, S.E. Noel, K. Mangano, K.L. Tucker. University of Massachusetts Lowell. C97 I 788.35 The Association Between Diabetic Indicators and Serum Iron Content in Different Ethnic Populations. J. Han, M.E. Kalan, S.H. Harrison, D. Yang. North Carolina Agricultural and Technical State University and University of Louisville. C98 II 788.36 Palm Oil in Myanmar: A Spatiotemporal Study of How Industrial Farming Affects Biodiversity Loss and the Sustainable Diet. K.M. Nicholas, J. Fanzo, K. MacManus. Columbia University and Johns Hopkins University. C99 I 788.37 Evaluating the Global Epidemic of NonCommunicable Disease Through a Nutritional Perspective by Income Levels. S. Kang, H. Lim. Kyung Hee University, Republic of Korea.
789. NUTRITION AND CHRONIC DISEASE EPIDEMIOLOGY Poster (Sponsored by: Nutritional Epidemiology RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C100 I 789.1 International Food Group Based Diet Quality and Risk of Coronary Heart Disease in Men and Women. T. Fung, S. Isanaka, W. Willett. Simmons College and Harvard TH Chan School of Public Health. C101 II 789.2 Association Between Circulating Magnesium Levels and Risk of Coronary Heart Diseases, Hypertension, and Type 2 Diabetes Mellitus: A Meta-Analysis of Prospective Cohort Studies. P. Xun, J. Wu, Q. Tang, W. Cai, K. He. Indiana University Bloomington, Shanghai Jiaotong University, People’s Republic of China. C102 I 789.3 A Priori-Defined Diet Quality Indexes, Biomarkers, and Risk of Type 2 Diabetes in Five Ethnic Groups: The Multiethnic Cohort. G. Maskarinec, S. Jacobs, A.A. Franke, K.R. Monroe, C.A. Haiman, L.N. Kolonel, L.R. Wilkens, L. Le Marchand, C.J. Boushey. University of Hawaii Cancer Center and University of Southern California. C103 II 789.4 The Relation of DIetary Glycemic Index and Glycemic Load to Glucose Homeostasis Among Adults WIthout Diabetes In Southwest China. H. Xue, J. Zhang, D. Li, J. Luo, J. Dai, A.E. Buyken, G. Cheng. Sichuan University, People’s Republic of China, Tsinghua University, People’s Republic of China, and University of Bonn, Germany.
MONDAY NUTRITION C104 I 789.5 Associations of Whole and Refined Grain Intakes with Adiposity-Related Cancer Risk in the Framingham Offspring Cohort (1991–2013). N. Makarem, E.V. Bandera, Y. Lin, N. McKeown, N. Parekh. Columbia University Medical Center, Rutgers School of Public Health & Cancer Institute of New Jersey, Jean Mayer USDA HNRCA, Tufts University and New York University College of Global Public Health. C105 II 789.6 Inverse Association Between Stature and Coronary Artery Disease and Stroke Risk: HeightBlood Pressure Relations as a Contributing Mechanism. B. Bourgeois, K. Watts, D.M. Thomas, O.B. Carmichael, F. Hu, M. Heo, J. Shepherd, S.B. Heymsfield. Pennington Biomedical Research Center, Louisiana State University, West Point Military Academy, Harvard Medical School, Albert Einstein College of Medicine, University of California at San Francisco. C106 I 789.7 Effects of Dietary Inflammatory Index and History of Gestational Diabetes Mellitus on Insulin Resistance. D. Shin, K. Lee, D.L. Tande, J. Hur, N. Shivappa, M.D. Wirth, J.R. Hébert. University of North Dakota, Michigan State University, University of South Carolina, Connecting Health Innovations and LLC. C107 II 789.8 Dietary Intake Evaluation and HealthRelated Quality of Life (HRQL) in Tuberculosis Patients with and Without Diabetes Mellitus. Q. Wang, A. Ma, Y. Liu, Y. Zhao, Y. Guo, Y. Zou, L. Sun, H. Tian, G. Jiang. Nutrition Institute, Qingdao University, Qingdao, People’s Republic of China, Qingdao Chest Hospital, Qingdao, People’s Republic of China. C108 I 789.9 The Impact of Diabetes on Typical Manifestation of Tuberculosis and the Nutritional Status. Q. Wang, A. Ma, S. Zhao, J. Cai, Y. Zhang, X. Han, T. Kou, B. Du, J. Song. Nutrition Institute, Qingdao University, Qingdao, People’s Republic of China, Linyi Chest Hospital, Linyi, People’s Republic of China. C109 II 789.10 Role of Nutrients in Metabolic Health: Updates in 2016. H.J. Kern, S.H. Mitmesser. The Nature’s Bounty Co. C110 I 789.11 Dietary Behaviors Characteristic for the Patients with Type 2 Diabetes Mellitus. M. Nakao, Y. Ishihara. Kurume University, Japan. C111 II 789.12 The Association Between Eating Frequency and Risk of Type 2 Diabetes: The Women’s Health Initiative Dietary Modification Trial. C.M. Clowry, S.J. Beatty, C.A. Thomson, B.C. Wertheim, M.L. Neuhouser. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mel & Enid Zuckerman College of Public Health, University of Arizona, University of Arizona Cancer Center, School of Public Health and University of Washington. C112 I 789.13 Avocado Consumption and Risk Factors of Heart Disease: A Systematic Review and Meta-Analysis. H. Mahmassani, E.E. Avendano, G. Raman, E.J. Johnson. Tufts University Friedman School of Nutrition Science and Policy, Tufts Medical Center and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts Univesity. C113 II 789.14 Relationship Between Egg and Meat Intake and Type 2 Diabetes Risk: Results from the Adventist Health Study. J. Sabaté, N. Burkholder-Cooley, K. Oda, G. Siapco. Loma Linda University. C114 I 789.15 Kimchi Consumption and the Incidence of Metabolic Syndrome in Korean Adults: Results from a 10Year Longitudinal Study. T. Hyun, S. Seo, Y. Han, Y. Song. Chungbuk National University, Republic of Korea, The Catholic University, Republic of Korea.
C115 II 789.16 Age at Diagnosis and Duration of Hypertension on the Adherence to the Dietary Approaches to Stop Hypertension (DASH) Diet. H. Kim, F. Andrade. Alma College and University of Illinois at Urbana-Champaign. C116 I 789.17 Gestational Weight Gain and Pregnancy Risk Factors Among Low Income Women. J. Kim, H. Chagarlamudi, S. Patil, E. Bray. East Carolina University. C117 II 789.18 Impact of Eggs on Dietary Nutrient Adequacy and Cardiovascular Risk in U.S. Adults. M.M. Melough, S. Chung, M. Fernandez, O.K. Chun. University of Connecticut, Kookmin University, Republic of Korea.
790. DIET AND CANCER Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C118 I 790.1 Lithocholic Acid Induces Apoptosis of Breast Cancer Cells MCF-7 and Inhibits Lipogenesis. J. Bard, T.H. Luu, D. Carbonnelle, C. Chailloux, J. Huvelin, C. Bobin-Dubigeon, H. Nazih. Université de Nantes, France, Metropolitan, Institut de Cancérologie de l’Ouest, France and Metropolitan. C119 II 790.2 Differential Anti-Proliferative Activity of Isoflavones Against Src-Activated Human Adenocarcinoma Cells. M. Ono, T. Higuchi, M. Takeshima, R. Wakimoto, S. Nakano. Nakamura Gakuen University, Japan. C120 I 790.3 Colon Cancer Prevention and Its Transcriptomics-Based Identification of Molecular Mechanisms by Dietary Intake of Soy Food. C. Jang, R.A. Sikes, C.J. Schmidt, C. Wu. University of Delaware. C121 II 790.4 The Proliferation and Invasion of Low Passage Number Human Colon Cancer Cell Lines Is Inhibited by Retinoids. M.M. Martinez, A. Hurst, C.P. Reynolds, M.A. Lane. Texas State University and Texas Tech University Health Sciences Center. C122 I 790.5 Effects of Vitamin E Derivatives on the Proliferation of KG-1 Leukemic Cells in Vitro. S. Rizk, P. Ghanem, A. Zouein, M.H. Hodroj. Lebanese American University, Lebanon. C123 II 790.6 Colorectal Cancer Cell Death by Pterostilbene Through Regulation of Bcl-2 Family Signaling Pathway. S. Chei, S. Choi, E. Koh, J. Choi, Y. Seo, J. Song, M. Park, J. Hwang, Y. Lee, K. Kim, B. Lee. CHA University, Republic of Korea. C124 I 790.7 Walnut Phenolic Extracts Reduced Both Telomere Length and Telomerase Activity in Colon Cancer Stem Cells. P. Shin, Y. Zoh, Y. Kim, S. Choi. CHA University, Republic of Korea, Ewha Womans University, Republic of Korea, Chaum Life Center CHA University, Republic of Korea. C125 II 790.8 CCAAT/Enhancer Binding Protein Beta (C/EBPβ) Gene Expression Is Regulated by Epigenetic Mechanisms in Human Colon Cancer Cells. X. Tang, L. Moody, H. Chen, Y. Pan. University of Illinois at Urbana-Champaign. C126 I 790.9 The Aryl Hydrocarbon Receptor Is a Repressor of Colorectal Cancer Development Induced by High-Fat Diet in Mice. E.L. Garcia-Villatoro, L. Davidson, E. Callaway, K. Allred, M. Hensel, A. Jayaraman, S. Safe, R. Chapkin, C.D. Allred. Texas A&M University.
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NUTRITION MONDAY C127 II 790.10 Resveratrol Inhibits Ovarian Cancer Cell Growth Through Epigenetic Regulation of Wnt Antogonist SFRP5. C. Liu, H. Yen, C. Tsao, H. Su, Y. Lin. Fu Jen Catholic University, Taiwan, Tri-Service General Hospital, National Defense Medical Center, Taiwan and National Defense Medical Center, Taiwan. C128 I 790.11 Inhibitory Effects of DHA and Its Peroxidation Product 4-HHE on Proliferation of Breast Cancer Cells. G. Chen, U. Ganbat, F. Tang. Department of Nutrition and China Medical University, Taiwan. C129 II 790.12 Taiwanin A Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Line BT-549. J. Syu, F. Tang, Y. Kuo. Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China, Taiwan, Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan and Republic of China, Taiwan. C130 I 790.13 Quercetin Reverses SorafenibResistant SK-Hep-1 Cells to Sorafenib by Up-Regulation of p53 Pathway. C. Huang, S. Huang, F. Jhan. Asia University, Taiwan and Chung Shan Medical University, Taiwan. C131 II 790.14 1α,25-Dihydroxyvitamin D3 Inhibits de Novo Fatty Acid Synthesis and Neutral Lipid Accumulation in Metastatic Breast Cancer Cells Through Downregulation of Pyruvate Carboxylase. T.M. Wilmanski, K. Buhman, S.S. Donkin, J. Burgess, D. Teegarden. Purdue University. C132 I 790.15 Identification and Quantitation of Furocoumarin Contents in Popularly Consumed Foods in the U.S. Using UPLC-MS/MS. M.M. Melough, S. Lee, E. Cho, K. Kim, A. Provatas, C. Perkins, M. Park, A. Qureshi, O.K. Chun. University of Connecticut, North Carolina Agricultural and Technical State University and Warren Alpert Medical School of Brown University. C133 II 790.16 Chemotherapeutic Effects of Avenanthramides on Breast Cancer Cells. J. Hastings, J. Kenealey. Brigham Young University. C134 I 790.17 1α,25-Dihydroxyvitamin D3 Inhibits Matrix Metalloprotease 2 Expression in Metastatic Breast Cancer Cells. H. Chae, T.M. Wilmanski, D. Teegarden. Purdue University. C135 II 790.18 Inhibitory Effects of DHA and Its Peroxidation Product 4-HHE on Human Colon Cancer Cells. Y. Lin, U. Ganbat, F. Tang. Department of Nutrition, China Medical University, Taichung, Taiwan and Republic of China, Taiwan. C136 I 790.19 Upregulation of Antioxidant Enzymes by Soybean-Derived Glyceollins Is Independent of p53 Expression in Human Colorectal Cancer Model. Y. Gwon, G. Jo, Y. Woo, G. Jeong, J. Kim, J.N. Averilla, H. Seo, S. Ju, J. Jang, J. Oh, J. Kim. Kyungpook National University, Republic of Korea. C137 II 790.20 Epigallocatechin-3-Gallate Sensitizes Multidrug-Resistant Oral Squamous Carcinoma Cells to Vincristine Sulfate Involving Angiogenesis Inhibition via DownRegulating VEGF in Vivo. Y. Hu, L. Chen, G. Zhang, L. Li, G. Liang. Guangxi Medical University, People’s Republic of China, The People’s Hospital of Guangxi Zhuang Autonomous Region, People’s Republic of China, First Affiliated Hospital of Guangxi Medical University, People’s Republic of China. C138 I 790.21 Dry Bean Consumption Inhibits Colorectal Tumorigenesis in Preclinical Studies: A MetaAnalysis of Animal Studies. T. Perera, Y. Takata, G. Bobe. Oregon State University.
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C139 II 790.22 In Vivo and in Vitro Evidence of Anticancer Effects of Omani Propolis Against Colon Cancer. M.I. Waly, H. Al Ajimi, H.T. Al-Lawati, N.I. Guizani, S.S. Rahman. Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos, Oman, Head of Honey bee Department MOAF, Head of Bee Products Healing Center, Oman, Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman, Oman, Food Science and Nutrition Department, College of Agricultural and Marine Sciences and Sultan Qaboos University, Oman. C140 I 790.23 Apoptotic Proteins Expression in Experimental Colon Cancer Model. S. Padmanabhan, V. Taranikanti, M. Waly. Sultan Qaboos University, Oman. C141 II 790.24 Piceatannol May Slow Cancer Cachexia-Induced Weight-Loss in Vivo. J. Kershaw, K. Kim. Purdue University. C142 I 790.25 Effect of Watermelon Powder Supplementation on Azoxymethane-Induced Colon Carcinogenesis in Rats. K. Glenn, D.S. Klarich, A. Figueroa, S. Hooshmand, M. Kern, M. Hong. San Diego State University and Florida State University. C143 II 790.26 Obesity Deteriorates DMBA-Induced Tumorigenesis in Vitro and in Vivo. C. Hsieh, S. Peng, M. Chou. National Taiwan Normal University, Taiwan. C144 I 790.27 Korean Solar Salt Suppresses Concomitant Induction of Obesity and AOM/DSS-Based Colon Cancer in C57BL/6 Mice. K. Park, J. Ju, E. Park, S. Choi. Cha University, Republic of Korea, Yonsei University, Republic of Korea, Docho Salt Co., Republic of Korea. C145 II 790.28 Low Folate Status Reprograms Warburg Metabolic Signaling Network to Induce Cancer Stem Cell-Like Signatures to Promote in Vivo Metastasis Tumorigenicity of Lung Cancers. W-J. Chen, R-F.S. Huang. Fu-Jen Catholic University, Taiwan. C146 I 790.29 Glyceollins Induce Tumor Growth in Mouse Xenograft Model of Human Colon Cancer in Nrf2Dependent Manner. G. Jeong, H. Seo, S. Ju, J H. Jang, Y. Woo, Y. Gwon, J.N. Averrila, J. Kim, S. Byun, J. Oh, J. Kim. Kyungpook National University, Republic of Korea. C147 II 790.30 Withdrawn. C148 I 790.31 Effect of a Mindful Eating Intervention on Cardiometabolic Markers in Overweight and Obese Postmenopausal Breast Cancer Survivors—A Pilot Study. E.L. Sattler, A.M. Washington, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, M. Davis. University of Georgia. C149 II 790.32 Consumption-Temperatures of Local Thin Gruels (atoles) Among Low-Income Women from Quetzaltenango, Guatemala: Implications for Mitigation of Upper Digestive Cancer Risk. R. García-Meza, E. Diaz-Ruiz, D. Fuentes, A. Maldonado, M. Escobar, C.L. Arriaga, N.W. Solomons. CeSSIAM, Guatemala. C150 I 790.33 Calcium to Magnesium Intake Ratio and Prostate Cancer Aggressiveness. O. Omofuma, L. Arab, L. Su, J. Bensen, E. Fontham, J. Mohler, S. Steck. Arnold School of Public Health, University of South Carolina, David Geffen School of Medicine, University of California Los Angeles, University of Arkansas, Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, School of Public Health, Louisiana State University Health Sciences Center and Roswell Park Cancer Institute.
MONDAY NUTRITION C151 II 790.34 Feasibility Outcomes of a Pilot Randomized Controlled Trial to Increase Cruciferous and Green Leafy Vegetable Intake in Post-Treatment Head and Neck Cancer Survivors. S.L. Crowder, A.D. Fruge, A. Delk, W.R. Carroll, S.A. Spencer, J.L. Locher, W. DenmarkWahnefried, L.Q. Rogers, A.E. Arthur. University of Illinois and University of Alabama at Birmingham. C152 I 790.35 Soy Consumption and the Risk of Prostate Cancer in Men: An Updated Systematic Review and Meta-Analysis. C.C. Applegate, J.L. Rowles III, K.M. Ranard, S. Jeon, J.W. Erdman Jr. University of Illinois at Urbana-Champaign. C153 II 790.36 Dietary Inflammatory Index and Objective and Subjective Memory Impairments in Breast Cancer Survivors. K.E. Zuniga, J. Fernandez. Texas State University. C154 I 790.37 Phytanic Acid in Dairy Products and Risk of Cancer: Current Evidence and Future Directions. Y. Takata, Z. Zhang, M. Garzotto, R. Kopp, G. Bobe, J. Shannon. Oregon State University and Oregon Health & Science University. C155 II 790.38 Red and Processed Meat Consumption and Pancreatic Cancer Risk in the Cancer Prevention Study-II Nutrition Cohort. M.L. McCullough, E.J. Jacobs, R. Shah, P.T. Campbell, Y. Wang, S.M. Gapstur. American Cancer Society. C156 I 790.39 Oxylipids Derived from Arachidonic and Dihomo-Gamma-Linolenic Acids Are Associated with Colon Polyps in Adult Males. Z. Yin, C.A. Pickens, L.M. Sordillo, J.I. Fenton. Michigan State University. C157 II 790.40 Gender Perspectives on the Relationship Between Red and Processed Meat Intake And Colorectal Cancer: A Systematic Review and Meta-Analysis. H. Lee, J. Lee, M. Kang, J. Shim, H. Paik. GISTeR, Republic of Korea, Seoul National University, Republic of Korea, Daejeon University, Republic of Korea. C158 I 790.41 Withdrawn. C159 II 790.42 Bioelectrical Impedance Utilization and Dietary Intake Relation in the Analysis of Risk of Lymphedema in Breast Cancer Survivors. Y. Han, H. Park, S. Lim, S. Lee. Yonsei University, Republic of Korea, Yonsei University College of Medicine, Republic of Korea. C160 I 790.43 Effect of a Mindful Eating Intervention on Biomarkers of Prognosis and Survival in Overweight and Obese Postmenopausal Breast Cancer Survivors—A Translational Pilot Study. A.M. Washington, M. Davis, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, B.D. Jenkins, E.L. Sattler. University of Georgia. C161 II 790.44 Socio-Demographic and Disease Related Factors Associated with Diet Quality Among Adult Cancer Patients. K. Kane, S. Ilic, H. Paden, M. Lustberg, C. Grenade, K. Mo, I. Hatsu. The Ohio State University. C162 I 790.45 Tender Coconut Water Inhibits the Growth of Human Liver Cancer Cell Line HepG2. J. Lakshmanan, B. Zhang, A. Motameni, B.G. Harbrecht, H.C. Polk; Jr. University of Louisville. C163 II 790.46 Development of Furocoumarin Database and Intake Trend of Furocoumarins in US Health Professionals. M. Park, O.K. Chun, M.M. Melough, A.A. Qureshi, E. Cho. Warren Alpert Medical School of Brown University, University of Connecticut, Brown School of Public Health and Brigham and Women’s Hospital.
C164 I 790.47 Estimation of Furocoumarin Intake of the U.S. Population in the National Health and Nutrition Examination Survey. M.M. Melough, K. Kim, E. Cho, A. Provatas, C. Perkins, M. Park, A. Qureshi, O.K. Chun. University of Connecticut and Warren Alpert Medical School of Brown University. C165 II 790.48 Does Maté Down Regulate Bcl2 Gene Expression to Cause a Selective Death of Cancerous Cells Through Apoptosis? K. Nisbett, A. Sadik. Touro University Nevada. C166 I 790.49 Young Adults Physical Activity Behavior and Chronic Disease Prevention Knowledge Across Appalachia. M.L. Barr, E.L. Beller, S.E. Colby, J. Morrell, T. Kidd, K. Riggsbee, M.D. Olfert. West Virginia University, University of Tennessee, University of New Hamshire and Kansas State University. C167 II 790.50 Retrospective Analysis on the Effect of Vitamin D Intake and Supplementation on Bone Mineral Density in Pediatric Leukemia Patients Who Underwent Allogeneic Bone Marrow Transplantation. M.N R. Lesser, L. Nguyen, E.B. Fung. UCSF Benioff Children’s Hospital, Oakland, University of California, Berkeley and Children’s Hospital Oakland Research Institute.
791. FOOD SECURITY AND ITS CONNECTIONS TO NUTRITION AND HEALTH Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C168 I 791.1 Food Security, Dietary Quality, and Use of Resources Are Low Among Rural U.S. Veteran Food Pantry Users in a Reaching Rural Veterans Pilot Intervention. B.N. Wright, M. Sternberg, A. Wellnitz, S. MacDermid Wadsworth, H.A. Eicher-Miller. Purdue University. C169 II 791.2 Food Insecurity and Food Behaviors of Male Collegiate Athletes. K. Poll, M. Valliant, H.D. Joung, D.H. Holben. University of Mississippi. C170 I 791.3 The Mediterranean Diet as a Sustainable and Healthy Diet for Food Security. N. Hwalla, S. El Labban, R. Bahn. American University of Beirut, Lebanon. C171 II 791.4 Personal Health Index, Food Security Status and Social Capital Items: A Study on Women with Young Children (Under 5) Living in Households with Different Levels of Food Security. D. Ahmadi, K. Sinclair, H. MelgarQuinonez, G. Helal, N. Ebadi, H. Monteith. School of Dietetics and Human Nutrition, Canada. C172 I 791.5 Prevalence of Food Insecurity of Adolescent Students from 83 Countries. H.T. Nguyen, E.A. Frongillo, M.S. Fram, J. Bernal. University of South Carolina and Universidad Simón Bolívar, Venezuela. C173 II 791.6 Association of Food Insecurity and the Nutritional Status of Mexican Mother-Child Pairs. T. ShamahLevy, V. Mundo-Rosas, C. Morales-Ruan, L. Cuevas-Nasu, I. Méndez Gómez–Humarán, R. Pérez-Escamilla. National Public Institute, Mexico., Mexico, National Institute of Public Health (INSP). National Public Institute, Mexico, Mexico, Center for Research in Mathematics (CIMAT), Mexico, Yale School of Public Health.
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NUTRITION MONDAY C174 I 791.7 Inter-Relationship Between Food Security Status, Money Spending, and Availability of Fruits and Vegetables at Home. S. Armah, J.M. Dharod. University of North Carolina-Greensboro. C175 II 791.8 Quality-of-Life, Risk for Malnutrition, and Polypharmacy Among Persons on Haemodialysis in Trinidad and Tobago. P. Prout, S. Nichols. The University of The West Indies, Trinidad and Tobago. C176 I 791.9 Haemodialysis, Risk of Food Insecurity, and Dietary Behaviours in Trinidad and Tobago. S. Nichols, P. Prout. The University of The West Indies, Trinidad and Tobago. C177 II 791.10 Food Security and International Migration: A Comparative Study of Asia, Middle East/North Africa, Latin America/Caribbean and Sub-Saharan Africa. N. Ebadi, D. Ahmadi, K. Sinclair, H. Melgar-Quinonez. McGill Institute for Global Food Security, Canada. C178 I 791.11 The Prevalence of Food Insecurity Among Pregnant Women in a Community-Based Intervention Program. N.E. Nnakwe. Illinois State University. C179 II 791.12 Madre Maiz, an Ancient Resilience Strategy Practiced by Mayan Groups in Times of Food Scarcity. O.I. Bermudez, A. Rivas Barrios, A. Martinez, P. Palma de Fulladolsa. Tufts University School of Medicine, Regional Program for Food and Nutrition Security, El Salvador and Central America University Council, Guatemala. C180 I 791.13 The Impact of Soci-Economic and Cultural Factors on Refugee Households’ Food Insecurity: A Snapshot of the Food Security Status of Afghan Refugees in Switzerland. M. Khakpour, L. Sadeghi, H. Jenzer, S. Martins, M. Farag, M. Koc, J. Garcea, C. Henry, R. Engler-Stringer, H. Vatanparast. University of Saskatchewan, Canada, Bern University, Switzerland and Ryerson University, Canada. C181 II 791.14 Monthly Variations in Food Intake and Diet Quality of Women Participating in the Supplemental Nutrition Assistance Program (SNAP). N. Sanjeevi, J.H. Freeland-Graves. The University of Texas at Austin. C182 I 791.15 Container Gardens to Meet Vegetable Needs During Dry Season for Reproductive Age Women and Their Children in Northern Ghana. C. Kubuga, S. Song, G. Kennedy, K. Lee, W. Song. Michigan State University, University for Development Studies, Ghana and Bioversity International, Italy. C183 II 791.16 The Relationship Between Food Insecurity, Weight Status, and Diet Quality Among Active Duty Service Members at a Large Military Installation. J. Lopera, B.D. Bustillos, K. Schmitz. Winn Army Community Hospital, Brooke Army Medical Center, U.S. Army-Baylor Graduate Program in Nutrition and William Beaumont Army Medical Center. C184 I 791.17 Household Food Insecurity Is Associated with Children’s Health and Developmental Risks, But Not with Age-Specific Obesity and Underweight. M.M. Black, C. Drennen, N. Gallego, S. Coleman, D.A. Frank. University of Maryland, Baltimore, Meharry Medical College, and Boston University. C185 II 791.18 Sex and Race/Ethnic Disparities in Food Security and Chronic Diseases in U.S. Older Adults. F.G. Huffman, J.A. Vaccaro, G.G. Zarini. Florida International University.
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C186 I 791.19 Food Insecurity During Pregnancy and the Early Postpartum Period Is Associated with Reduced Exclusive Breastfeeding at Four Months Postpartum in a Cohort of Women in Western Kenya. M. Bates, T. Hartman, F. Grant, A. Webb Girard. Rollins School of Public Health, Emory University and International Potato Center, Kenya. C187 II 791.20 Food Security Status Is Associated with Diet Quality in Indiana Supplemental Nutrition Assistance Program-Education (SNAP-Ed) Eligible Adults. R.L. Rivera, M.K. Maulding, A.R. Abbott, Q. Wang, H.A. Eicher-Miller. Purdue University. Greater Perseverance and C188 I 791.21 Determination Predicts Lower Odds of Food Insecurity in Households with Children. C.J. Nikolaus, M.J. Schierer, S.M. Nickols-Richardson. University of Illinois at Urbana-Champaign. C189 II 791.22 Experiences of Household Food Insecurity in Rural Colombia: Qualitative Analysis of Women Smallholder Farmers. B. Burkhardsmeier, E. Rhodes, A. Webb Girard, K.M. Yount, D. Hines. Rollins School of Public Health, Emory University, United Nations World Food Programme and Colombia, Colombia. C190 I 791.23 Nutrient Status of Clients of a Soup Kitchen. J. Freeland-Graves, T. Mousa. University of Texas at Austin. C191 II 791.24 Proximate Analysis, Mineral and Nitrate Contents of Hydroponically Cultivated Lettuces. T. Siritientong, S. Pongthananikorn, L. Tongyonk. Chulalongkorn University, Thailand. C192 I 791.25 Predicting Weight Gain in Adults— Results from a Multi-Center Cohort Approach. H. Boeing, A. Steffen. German Institute of Human Nutrition, Germany. C193 II 791.26 Examining the Role of Habitual Physical Activity in the Food Insecurity-Obesity Paradox. A.R. Covello, C.J. Nikolaus, M.R. Curran, C.G. Edwards, N.W. Baumgartner, R.H. Liu, E.H. Loehmer, J.H. McCaffrey, R.H. An, N.A. Khan. University of Illinois at Urbana-Champaign. C194 I 791.27 Is Food Security Influencing Emotional Health? A Study with Hispanic Immigrant Mothers. E. Villegas, B. Hannon, A. Hammons, M. Teran-Garcia, A. Wiley. University of Illinois Champaign Urbana and California State University. C195 II 791.28 Rural Women: The Most Vulnerable to Food Insecurity and Poor Health in the Global South. K. Sinclair, D. Ahmadigheidari, D. Dallmann, H. MelgarQuiñonez. McGill University, Canada. C196 I 791.29 Social Determinants of Food Insecurity in the Arab Region: A Comparative Study. O.B. Sheikomar, E. Wambogo, N. Sahyoun, H. Ghattas. University of Maryland, College Park and American University of Beirut, Lebanon. C197 II 791.30 Food Cost Concerns Affect Food Choice and Dietary Intake in a Population of Inner City Kidney Transplant Recipients. E. Ruff, S. Mincer, M. Markell. SUNY Downstate Medical Center. C198 I 791.31 Women’s Empowerment, Prevention of Malnutrition in Children Under 2 Approach, and Agricultural Interventions Improved Household Dietary Diversity and Household Food Insecurity in South Kivu, DR Congo. J.A. Emerson, J. Strong, E. Colantuoni, L.E. Caulfield, S. Doocy. Johns Hopkins Bloomberg School of Public Health and University of Maryland School of Medicine.
MONDAY NUTRITION C199 II 791.32 Food Insecurity Among College Students at West Virginia University and Self-Reported Health Status. R.L. Hagedorn, M.L. Barr, O.A. Famodu, A.M. Morris, R.L. Clark, M.D. Olfert. West Virginia University. C200 I 791.33 Food Insecurity and Coping Strategies Among Senior Citizens in Lubbock, Texas. B.A Z. Abu, W. Oldewage-Theron. Texas Tech University.
792. EXPERIMENTAL ANIMAL NUTRITION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C201 I 792.1 Metabolite Changes in the Zebrafish Model of Fetal Alcohol Spectrum Disorder Associated with Established Neural Abnormalities. C.E. Keller, M.S. Sepúlveda, A.H. Jannasch, A.M. Roumani, F.C. Zhou, P.B. Brown. Purdue University, Gulf University for Science & Technology, Kuwait and Indiana University. C202 II 792.2 Can Voluntary Exercise Improve Renal Changes in Offspring Induced by Maternal Obesity. S. Chowdhury, H. Bahari, V. Caruso, C. Maloney, M. Morris. University of New South Wales, Australia. C203 I 792.3 Hippocampal Phosphatidylcholine Stearic Acid Mediates the Relationship Between Serum Triacylglycerol Eicosanoic Acid and Hippocampal Myo-Inositol in the Young Pig. A.T. Mudd, R.V. Waworuntu, B.M. Berg, S.M. Donovan, R.N. Dilger. University of Illinois and Mead Johnson Pediatric Nutrition Institute. C204 II 792.4 A Maternal Diet Enriched with Longer Chain Omega-3 Polyunsaturated Fatty Acids Increased Lipogenesis and Fetal Outcome in C57bl/6 Mice. O.A. Akerele, S.K. Cheema. Memorial University of Newfoundland and Labrador, Canada. C205 I 792.5 Male Testicular Development Is Affected by Estrogens but Not Altered in Neonatal Piglets Receiving Soy Infant Formula. K.E. Mercer, C. Chen, L. Hennings, H. Dawson, L. Yeruva, M. Ronis, T. Badger. Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences and Beltsville Human Nutrition Research Center. C206 II 792.6 Maternal Exposure to Hesperidin and Naringin Flavanones Exerts Transient Effects to Tibia Bone Microstructure in Female CD-1 Offspring. S.M. Sacco, C. Saint, P.J. LeBlanc, W.E. Ward. Brock University, Canada. C207 I 792.7 Maternal Obesity During Pregnancy Uniquely Programs Offspring Aortic and Perivascular Adipose Tissue Transcriptomes. K.M. Thakali, E.C. Wahl, U.D. Wankhade,Y. Zhong, K. Shankar. Arkansas Children’s Nutrition Center and University of Arkansas for Medical Sciences. C208 II 792.8 Pancreas Development and Nutrient Uptake and Utilization Are Disrupted by Embryonic Exposures to the Environmental Toxicant Perfluorooctanesulfonic Acid in the Zebrafish. K.E. Sant, H.M. Jacobs, K.A. Borofski, P. Chen, Y. Park, A.R. Timme-Laragy. University of Massachusetts Amherst. C209 I 792.9 Maternal Obesity Increases Sweet Taste Response and Sweet Taste Receptor mRNA Expression in Adult Offspring. E. Choo, R. Dando. Cornell University.
C210 II 792.10 Maternal Diet-Induced Hypercholesterolemia Programs Lipoprotein Metabolism by Increasing VLDL Particle Number and Size in C57BL6/J Mouse Progeny. J. Mathew, J.H. Dumolt, A. Raslawsky, T.C. Rideout. State University of New York at Buffalo. C211 I 792.11 Infant Formula Feeding Alters the Proliferative Status of Neonatal Mammary Glands Independent of Estrogen Signaling. S. Bhattacharyya, K.E. Mercer, L. Hennings, M. Chaudhurry, L. Yeruva, M. Ronis, T. Badger. Arkansas Children’s Nutrition Center and University of Arkansas for Medical Sciences. C212 II 792.12 Modulation of Nutrient Sensing Networks by Anti-Nutritional Factors in Fish. G. He, F. Bian, J. Tian, K. Wang, H. Zhou. Ocean University of China, People’s Republic of China. C213 I 792.13 Effects of Collagen Peptide on Bone in Mice with Methionine Restriction Diet. H. Guo, Y. Wang, J. Zhang, Y. Shi, G. Le. Food Nutrition and Functional Factors Research Center, People’s Republic of China, Food Nutrition and Functional Factors Research Center, People’s Republic of China, The Laboratory of Food Nutrition and Functional Factors, People’s Republic of China. C214 II 792.14 Tissue-Specific Macronutrient Allocation Is Directly Affected by Macronutrient Intake in the Cultured Sea Urchin, Lytechinus variegatus, Nutrition Model. Y. Yuan, L.E. Heflin, M.L. Powell, A.L. Lawrence, S.A. Watts. University of Alabama at Birmingham and Texas A&M University. C215 I 792.15 The Evolution of Satiety: Studies in the Sea Urchin, Lytechinus variegatus, Nutritional Model. M.D. Hayes, B. McCafferty, L. Heflin, J.M. Lawrence, D. Raubenheimer, S.A. Watts. University of Alabama at Birmingham, University of South Florida and University of Sydney, Australia. C216 II 792.16 Activation of Adrenergic Receptor Subtypes Differentially Regulates Expression of Metabolic Genes in Porcine Adipocytes. S. Shin, K.M. Ajuwon. Purdue University. C217 I 792.17 Dogs and Cats Differ in Metabolomics When Allowed to Freely Choose Macronutrient Intake. D.E. Jewell, J.C. Vondran, M.A. Vanchina, M.E. Jackson, J.A. Hall. Hill’s Pet Nutrition, Inc. and Oregon State University. C218 II 792.18 Upregulation of Glucose Production by Increased Dietary Protein in the Adult Cat (Felis catus). T.J. Wester, K. Weidgraaf, M. Hekman, B.J. Bequette, N.J. Cave, M.H. Tavendale. Massey University, New Zealand, University of Maryland and AgResearch Grasslands, New Zealand. C219 I 792.19 Sex-Specific Differences in the Development of Diet-Induced Obesity in a Zebrafish Model. L.A. Fowler, L. Dennis, J.A. Dawson, R.J. Barry, J.L. Davis, M. Powell, Y. Yuan, M. Williams, S. Watts. University of Alabama at Birmingham and Texas Tech University. C220 II 792.20 Trabecular Bone Microarchitectural Outcomes of the Mandible and Tibia or Lumbar Vertebrae Are Correlated in SHAM but Not the OVX Rat Model of Postmenopausal Osteoporosis. A. Longo, W. Ward. Brock University, Canada. C221 I 792.21 Hypercaloric Diet Does Not Induce Metabolic Syndrome in Wistar Rats. A. Medeiros, E.O. Moura, M.F. Gomes, N.M. Cardoso, A.C. Santos, M.C. Kubota, D. Estadella. Universidade Federal de São Paulo, Brazil.
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NUTRITION MONDAY C222 II 792.22 Evaluation of the Glycemic and Insulinemic Responses Related to the Consumption of Enzymatically Reduced Glycemic Index Wheat Flour in Murine Model. C.G. Plazas, F. Cabrera-Chavez, A. OchoaAcosta, M.J. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico. C223 I 792.23 Impact of Fiber-Bound Polyphenols on Gut Microbiome Metabolism Is Influenced by Background Diet. M.I. Jackson, D.E. Jewell. Hill’s Pet Nutrition. C224 II 792.24 The Gastrointestinal Tract of Piglets from First Parity Sows Develops More Slowly and Is More Permeable Than Piglets from Later Parity Sows. J.J. Cottrell, J. Craig, U.A. Wijesiriwardana, L. Fothergill, M.T. Ringuet, K. O’Hallorhan, D.L. Turpin, L.M. Munoz, C.L. Collins, J.B. Furness, F.R. Dunshea, J. Pluske. The University of Melbourne, Australia, Murdoch University, Australia and Rivalea Pty Ltd, Australia. C225 I 792.25 Low Dietary Vitamin D with a Regular Level of Calcium Prior to and During Pregnancy and Lactation Has No Effect on Trabecular Bone Structure of Mouse Dams. C.R. Villa, S.M. Sacco, J. Chen, E.M. Comelli, W.E. Ward. University of Toronto, Canada and Brock University, Canada. C226 II 792.26 Low Dietary Vitamin D Since Pre-Mating Does Not Modify Fecal Bacteroides Counts of Mouse Dams at the End of Pregnancy. C.R. Villa, A. Taibi, S. Kasee, J. Chen, W.E. Ward, E.M. Comelli. University of Toronto, Canada and Brock University, Canada.
793. EFFECTS OF DIETARY BIOACTIVE COMPONENTS IN EXPERIMENTAL MODELS OF CHRONIC DISEASE RISK Poster (Sponsored by: Dietary Bioactives Components RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C227 I 793.1 The Effects of a High- And LowDaidzein Diet on Liver Steatosis and Serum Adipokines in Female Obese Zucker Rats. A. Bell, S. Korourian, H. Zeng, J. Phelps, T. Crook, B. Gurley, R. Feresin, R. Hakkak. Arkansas Children’s Research Institute, University of Arkansas for Medical Sciences, United States Department of Agriculture and Agricultural Research Service. C228 II 793.2 Potential Effects of Javamide-I Found in Coffee on Inflammatory Chemokine MCP-1 in Rats Fed a High Fat Diet. J. Park. BHNRC. C229 I 793.3 Impact of Piceatannol and Resveratrol on the Proteomic Profile of Caenorhabditis elegans. J.M. Oshiro, P. Shen, O. Wang, Y. Park, K. Kim. Purdue University, University of Massachusetts Amherst, Chinese Centre for Disease Control and Prevention, and People’s Republic of China. C230 II 793.4 Yacon (Smallanthus sonchifolius) Improves Gut Health in Animal Model of Colon Cancer. N.M. Costa, M.M. Grancieri, M.L. Viana, M.G. Tostes, M.D. Ignacchiti. Federal University of Espirito Santo, Brazil.
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C231 I 793.5 Effects of Lycium barbarum Polysaccharides Extract and Betaine on Cell Activation and Liver Fibrosis in Rat Hepatic Stellate HSC-T6 Cells. J.C. Chao, B. Li. Taipei Medical University, Taiwan and Taipei Medical University Hospital, Taiwan. C232 II 793.6 Systemic Metabolomic Changes in Mice Fed a High Fat Diet and Supplemented with Lactobacillus plantarum. A. Martinic, D. Mishchuk, J. Barouei, Z. Bendiks, D. Heeney, D. Kieffer, R. Martin, M. Marco, C. Slupsky. University of California, Davis and USDA-ARS-Western Human Nutrition Research Center. C233 I 793.7 Effects of Flaxseed Supplementation on Intestinal Tight Junction Protein and TNF-Alpha Gene Expression in Obese Mice. K. Silvernagel, M. Mann, A. Wiltgen, Y. Rhee. North Dakota State University. C234 II 793.8 Wheat Germ Supplementation Alleviates Insulin Resistance and Cardiac Mitochondrial Dysfunction in an Animal Model of Diet-Induced Obesity. B. Ojo, A.J. Simenson, C. O’Hara, L. Wu, X. Guo, S.K. Peterson, D. Lin, B.J. Smith, E.A. Lucas. Oklahoma State University. C235 I 793.9 Alacalase-Hydrolyzed Camellia Seed Hull Inhibited Angiotensin Converting Enzyme Activity and Lowered Blood Pressure in Spontaneous Hypertensive Rats. J. Pan, H. Lim, E. Shin, J. Kim. University of Arkansas, Gyeongnam National University of Science and Technology, Republic of Korea. C236 II 793.10 Root Bark of Ulmus davidiana var. japonica Ameliorates Alcohol-Induced Hepatic Steatosis in Mice by Inhibiting Oxidative Stress-Mediated MAPK Activation. J. Pan, Y. Lim, H. Shin, J. Kim, K. Lee, J. Kim, J. Lee, Y. Kim. Korea University, Republic of Korea, and University of Arkansas. C237 I 793.11 Inhibitory Effects of Nobiletin on Colitis Were Associated with Altered Gut Microbiota. M. Gu, X. Cai, M. Song, Z. Li, F. Li, T. Goulette, H. Xiao. University of Massachusetts Amherst. C238 II 793.12 Muscadine Grape Extract Improves Exercise Capacity and Reduces Oxidative Stress in Aging Transgenic (mRen2)27 Hypertensive Female Rats. A.V. Duncan, W. Graham, E.N. Tommasi, P.E. Gallagher, E.A. Tallant, M.C. Chappell, D.I. Diz. Wake Forest School of Medicine. C239 I 793.13 Effect of Mexican Oregano on Colon Cancer Cells. S. Lee, P. Ward, C.R. Brownmiller. University of Arkansas. C240 II 793.14 Dietary Compound Chrysin Suppressed Glomerulosclerosis in High Glucose-Exposed Renal Mesangial Cells and Diabetic Mice. E. Lee, M. Kang, Y. Kang. Hallym University, Republic of Korea. C241 I 793.15 Oleuropein Ameliorates Airway Inflammation and Emphysema in a Chronic Obstructive Pulmonary Disease Model. Y. Kim, Y. Choi, Y. Kang. Hallym University, Republic of Korea, Maeil Co, Republic of Korea. C242 II 793.16 Bioactive Compounds of the Ubá Mango Juice Decrease Inflammation and Hepatic Steatosis in Obese Wistar Rats. H.S. Martino, D. Natal, M.C. Moreira, M.H. dos Santos. Federal University of Viçosa, Brazil. C243 I 793.17 Moringa Leaf Powder Attenuates Hepatic Steatosis and Decreases Inflammation by Altering the Expression of Genes Involved in Lipid Synthesis. M.M. Almatrafi, M.M. Vergara-Jimenez, G.G. Murillo, G.H. Norris, C.N. Blesso, M.M. Fernandez. University of Connecticut, University of Sinaloa, Mexico and University of Costa Rica, Costa Rica.
MONDAY NUTRITION C244 II 793.18 Effects of Dietary Isoflavone Daidzein on Fecal Short-Chain-Fatty-Acid and Serum Cytokines in Obese Female Zucker Rats. R. Hakkak, A. Bell. University of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. C245 I 793.19 Muscadine Grape (Vitis rotundifolia) or Wine Supplement Alleviates Intestinal Inflammation in a Chronic Colitis Mice Model. R. Li, S. Zhao, Y. Yagiz, L. Gu. University of Florida. C246 II 793.20 Dose Response Effects of a BlueberryEnriched Diet on Net Bone Calcium Retention in Ovariectomized Rats. M. Maiz Rodriguez, C. Henry, P.J. Lachcik, M. Ferruzzi, G. McCabe, M.A. Lila, C.M. Weaver. Purdue University and North Carolina State University. C247 I 793.21 Consumption of Whole Aronia Berry Powder Inhibits Adoptive Transfer-Induced Colitis in Mice. R. Pei, D. Martin, B. Bolling. University of Wisconsin-Madison.
794. OBESITY II Poster (Sponsored by: Obesity RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C248 I 794.1 Indomethacin, a Nonsteroidal AntiInflammatory Drug, Enhanced Brown Fat Activity in Vitro and in Vivo. L. Hao, J. Kearns, L. Zhao, S. Wang. Texas Tech University, University of Tennessee and Knoxville. C249 II 794.2 Prior Exposure of Angiogenic Factors Promote Cell-Autonomous Brown Adipogenesis of Human Classical Brown Precursor Cells. J. Kim, S. Chung. University of Nebraska Lincoln. C250 I 794.3 Postprandial Variations in Gut Incretins Associated with Obesity Status and Race. S.M. Langdon, J. Randolph, I. Edirisinghe, F. Steinberg, B. Burton-Freeman. University of California, Davis, Institute for Food Safety and Health and Illinois Institute of Technology. C251 II 794.4 The Reinforcing Value of Vegetables Does Not Increase With Repeated Exposure During a Randomized Controlled Provided Vegetable Intervention Among Overweight and Obese Adults. L. Jahns, L.K. Johnson, J. Temple, N.L. Keim, S. Casperson, J.N. Roemmich. USDA-ARS Grand Forks Human Nutrition Research Center, University of Buffalo and USDA-ARS Western Human Nutrition Research Center. C252 I 794.5 Primary Motor Cortex Mediates the Association Between Body Mass Index and Reaction Times to Visual Food-Cues in Subjects with Obesity: An fMRI Food-Cue Reactivity Study. C.N. Kahathuduwa, T. Davis, M. O’Boyle, M. Binks. Texas Tech University, Faculty of Medicine and University of Peradeniya, Sri Lanka. C253 II 794.6 Effect of Mid-Morning Snacks on Subjective Appetite, Food Intake, and Glucose and Insulin Responses in Healthy Men and Women. Q. Guo, J. Hayden, J. Chang, J. Totosy de Zepetnek, S.J. Crozier, D. Rousseau, N. Bellissimo. Ryerson University, Canada and The Hershey Company.
C254 I 794.7 Effects of Voluntary Running with Defined Distances on Body Adiposity and Its Associated Inflammation in Mice Fed a High-Fat Diet. L. Yan, S. Sundaram. C255 II 794.8 The Effect of Red Raspberry on Satiety. L. Huang, D. Xiao, E. Park, I. Edirisinghe, B. BurtonFreeman. Illinois Institute of Technology. C256 I 794.9 Substitution or Addition? How Overweight and Obese Adults Incorporate Vegetables Into Their Diet During a Randomized Controlled Vegetable Feeding Trial. L. Jahns, Z. Conrad, L.K. Johnson, J. Temple, N.L. Keim, J.N. Roemmich. USDA-ARS Grand Forks Human Nutrition Research Center, University of Buffalo and USDAARS Western Human Nutrition Research Center. C257 II 794.10 Subjective and Objective Assessment of Physical Activity—Influence of Newly Diagnosed Exercise Induced Bronchoconstriction and Gender. U. Holmback, M. Berglund, H. Johansson. Uppsala University, Sweden. C258 I 794.11 Development and Validation of a New Prediction Equation for Energy Expenditure In Mexican Adults with Overweight and Obesity. X. Orozco-Ruiz, M. GuevaraCruz, E. Pichardo Ontiveros, N. Torres, I. Medina-Vera, P. Villanueva- Luna, C.L. Lafortuna, F. Prinelli, A.R. Tovar. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico and Consiglio Nazionale delle Ricerche, Italy. C259 II 794.12 DUSP5 Functions in a Feedback Loop to Suppress TNFα-Induced ERK1/2 Phosphorylation and Inflammation in Adipocytes. J.S. Habibian, M. Jefic, A. Schepps, R.A. Bagchi, R.A. McKnight, T.A. McKinsey, R.F. Morrsion, B.S. Ferguson. University of Nevada Reno, University of Colorado Denver, University of Utah and University of North Carolina Greensboro. C260 I 794.13 Consumption of an EPA and DHA Rich Diet Rescues Changes in White Adipose Tissue Lipid Metabolism and Oxylipin Production Induced in Fads2-Null Mice. O. Sarr, G.W. Payne, S. Abdelmagid, M.T. Nakamura, D.W. Ma, D.M. Mutch. University of Guelph, Canada and University of Illinois. C261 II 794.14 Differential Relationship Between Thigh and Calf Intermuscular Adipose Tissue Depots and Muscle Compartments with Indices of Cardio-Metabolic Health. R.E. Bergia, J. Kim, W.W. Campbell. Purdue University. C262 I 794.15 The Effects of Methionine Restriction on Thyroid Hormones and Mitochondrial Changes in Skeletal Muscle. J. Zhang, Y. Wang, H. Guo, Y. Shi, G. Le. Food Nutrition and Functional Factors Research Center, People’s Republic of China, Food Nutrition and Functional Factors Research Center, People’s Republic of China, The Laboratory of Food Nutrition and Functional Factors, People’s Republic of China. C263 II 794.16 High Fat Diet Impairs Mitochondrial ADP Sensitivity and Attenuates Respiration in the Presence of Submaximal, but Not Maximal, ADP Concentrations. P.M. Miotto, G.P. Holloway. University of Guelph, Canada. C264 I 794.17 Elevated Muscle Inflammatory Response After Protein-Dense Food Ingestion in Obese Adults. S.K. Skinner, J. Beals, S. Van Vliet, G.M. Niemiro, A.C. Dilger, M. De Lisio, S. Paluska, N.A. Burd. University of Ottawa, Canada. C265 II 794.18 High-Fat Diets Enriched with Varying Fatty Acid Compositions Have Differential Effects on Skeletal Muscle Troponin T Pre-mRNA Alternative Splicing. A. Black, R. Schilder, S. Kimball. Penn State College of Medicine and Penn State University.
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795. NUTRITION, DIETARY SUPPLEMENTS AND HUMAN PERFORMANCE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C266 795.1 Plasma Amino Acid, Glucose and Insulin Response to a Metered Intake of Milk or CarbohydrateElectrolyte Solution During 5 h Recovery from Exercise in Healthy Active Young Men. P. Jakeman, S. Seery, W. McCormack. University of Limerick, Ireland. C267 795.2 Relationship Between Within-Day Energy Balance on Body Composition in Professional Cheerleaders. M.P. Bellissimo, D. Benardot, W. Thompson, A. Nucci. Emory University and Georgia State University. C268 795.3 Rhaponticum carthamoides and Rhodiola rosea Plant Extracts: The Right Combination Between Both to Get the Optimal Effect on Muscle de Novo Protein Synthesis and Performance Gain. P. Fança-Berthon, S. Campredon, G. Py, V. Descossy, C. Tran Van Ba, A. Philippe, B. Vernus, C. Bertrand-Gaday, L. Falcao, A. Bily, M. Roller, A. Bonnieu. Naturex, France, INRA, UMR866 Dynamique Musculaire Et Métabolisme and Université de Montpellier, France. C269 795.4 VIA Instant Coffee Enhances the Effect of Post-Activation Potentiation in the Counter Movement Jump. A. Trivisonno, K. Ruffner, B. DiFiore, B. Smith, G. Slack, M. Harris, R. Mendel, L. Lowery. University of Mount Union. C270 795.5 Biotin Supplements: A Hair-Raising Challenge to the Analytical Accuracy of Clinical Immunoassays. E.W. Holmes, J. Garbincius, K. McKenna. Loyola University Chicago Stritch School of Medicine and Loyola University Medical Center. C271 795.6 Influence of Sports Drink Taste Preference on Consumption in Adult Male Soccer Players. A.M. Mistry, K. Molavi. Eastern Michigan University. C272 795.7 Prevalence of Dietary Supplement Use: Association of Sociodemographic and Lifestyle Factors, Awareness and Attitude Among Female College Students in Saudi Arabia. H.A. Alfawaz. King Saud University, Saudi Arabia. C273 795.8 Sports Nutrition Knowledge Among Japanese Coaches. S. Miyazaki, K. Okamura, Y. Okumura. Osaka University of Health and Sport Sciences, Japan. C274 795.9 Athletes’ Attitude on Foods as Snacks. Y. Okumura, K. Okamura, S. Miyazaki, K. Ishihara, Y. Yokota, M. Matsumoto. Osaka University of Health and Sport Sciences, Japan, Ryukoku University, Japan, Teikyo University, Japan and Nihon University, Japan. C275 795.10 Safety and Efficacy of Furosap, a Novel Trigonella foenum-graecum Seed Extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Human Volunteers. M. Bagchi, A. Swaroop, H.G. Preuss, D. Bagchi. Dr. Herbs LLC, Cepham Research Center and Georgetown University Medical Center. C276 795.11 Bone Mass and Nutrient Intake of Female Collegiate Athletes by Exercise Type. J. Shin, L. Okhee. Yongin University, Republic of Korea.
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C277 795.12 Body Composition and Dietary Assessment and Its Relationship with Knowledge of Nutrition in Young Athletes. A.N. Mendoza Hernandez, M.J. Castillo, A.E. Nuñez-Guzman. Universidad Popular Autonoma del Estado de Puebla, Mexico. C278 795.13 Postprandial Variability of Cognitive Inhibitory Control Following Dairy Milk Versus Fruit Juice in Children. J.R. Anderson, J. Gunstad, A. Sato, J. Updegraff, M. Spitznagel. Kent State University.
796. ENERGY BALANCE, MACRONUTRIENTS AND WEIGHT MANAGEMENT Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C279 I 796.1 Validity of the Output Variables of Body Composition in Healthy Guatemalan Adults Using the SECA mBCA 525 Bioelectrical Impedance Analyzer. C.L. Arriaga, C. Tanchez, L.A. Diaz-Jereda, N.W. Solomons, K. Schümann. CeSSIAM, Guatemala and Hildegard Grunow Foundation, Germany. C280 II 796.2 Fiber Intake, Dietary Energy Density, and Adherence to Diet Assignment Are Positively Associated with Weight Loss in Free-Living Adults Consuming CalorieRestricted Diets at 6-Month Follow-Up: The POUNDS LOST Study. D. Miketinas, G. Bray, F. Sacks, C. Champagne. Louisiana State University, Pennington Biomedical Research Center and Harvard T.H. Chan School of Public Health. C281 I 796.3 Fiber Intake, Dietary Energy Density, and Diet-Type Predict 6-Month Weight-Loss in Free-Living Adults Who Adhered to Prescribed Macronutrient and Energy Composition of Varying Diets. C.M. Champagne, G. Bray, F. Sacks, D. Miketinas. Pennington Biomedical Research Center, Harvard T.H. Chan School of Public Health and Louisiana State University. C282 II 796.4 Dietary Energy Density Is Positively Associated with Body Composition in Chinese Adults: A CrossSectional Study. J. Yin, Y. Chen, H. Xue, G. Cheng. West China School of Public Health, Sichuan University, People’s Republic of China. C283 I 796.5 Weight Loss Due to Low-Fat Feeding in Female Mice with Obesity Induced by High-Fat Feeding Reduces Both Body Fat and Bone Status. E.A. Sawin, B.M. Stroup, S.G. Murali, D.M. Ney. University of Wisconsin-Madison. C284 II 796.6 Characteristics of Participant Dropouts in a 1-Year Randomized Controlled Trial of Weight Gain Prevention. C.J. Metzgar, S.M. Nickols-Richardson. Virta Health and University of Illinois at Urbana-Champaign. C285 I 796.7 The Body Composition Changes and Energy Requirements for Body Weight Gain in Rats. H. Inoue, K. Okamura, M. Maeda, E. Kondo, Y. Okumura, S. Miyazaki. Osaka University of Health and Sport Sciences, Japan. C286 II 796.8 Association of Hot Pepper Consumption with Other Eating Habits Among Adults. C. Wang, L. Huang, C. Butler. Kentucky State University.
MONDAY NUTRITION C287 I 796.9 Frequency of Consuming Foods Predicts Changes in Cravings for Those Foods During Weight Loss: The POUNDS Lost Study. J.W. Apolzan, C.A. Myers, C.M. Champagne, R.A. Beyl, H.A. Raynor, S.A. Anton, D.A. Williamson, F.M. Sacks, G.A. Bray, C.K. Martin. Pennington Biomedical Research Center, University of Tennessee, University of Florida and Harvard T.H. Chan School of Public Health. C288 II 796.10 Dietary Adherence and Macronutrient Intake During 12 Months of Alternate Day Fasting. K.A. Varady, K. Gabel. University of Illinois at Chicago. C289 I 796.11 Acute Effects of Dried Apple Consumption on Metabolic and Cognitive Responses in Healthy Individuals. K. Zimmerman, M. Kern, M. Hong, C. Liu, S. Hooshmand. San Diego State University. C290 II 796.12 Effects of Pre-Dinner Snack on Cafeteria Meal Choice and Nutrition Quality in College Freshman. H.J. Scott, M.B. Hoppe, S.A. Schmitz, A.C. Eastep, P.L. Sebranek, S.E. Kern, I.E. Horwath, T. Wilson. Winona State University. C291 I 796.13 Effect of Snack Choice on Pre-Meal Hunger and Post-Meal Satiety in College Freshmen. A.C. Eastep, S.E. Kern, S.A. Schmitz, P.L. Sebranek, M.B. Hoppe, H.J. Scott, I.E. Horwath, T. Wilson. Winona State University. C292 II 796.14 Bright Line Eating: A Novel Web-Based Weight Loss Program. A.K. Thaw. Millsaps College. C293 I 796.15 The Effect of Buckwheat and Couscous on Satiety and Short-Term Food Intake in Young Males. H. Stirling, S. Keddy, J. Jamieson, S. Grant, B.L. Luhovyy. Mount Saint Vincent University, Canada and St. Francis Xavier University, Canada. C294 II 796.16 New Insights Into the Mayer Hypothesis Derived from a Dynamic Energy Balance Model. D. Thomas, J. Starner, A. Vaidya, A. Silva, S.B. Heymsfield, D.B. Allison. United States Military Academy, Montclair State University, University of Lisbon, Portugal, Pennington Biomedical Research Center, University of Alabama at Birmingham. C295 I 796.17 Energy Intake During the Last Supper: Insights from Mathematical Models. C. Aselton, D. Thomas, A. Salinas. United States Military Academy.
797. OBESITY AND THE METABOLIC SYNDROME Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) (Cosponsored by: Obesity RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C296 I 797.1 Nutrition Education and Meal Replacement : A Combined Intervention Strategy Among Obese Adolescent Girls with Metabolic Syndrome. C.A. Kalpana. Avinashilingam Institute for Home Science and Higher Education for Women, India. C297 II 797.2 Proteomic Analysis of 3T3-L1 Adipocytes Treated with Methylglyoxal: The Potential Impact of Dietary Sugar on Adipocyte Metabolism. S.M. Komanetsky, V. Hedrick, T.J. Paschoal Sobreira, K. Kim. Purdue University.
C298 I 797.3 Hyperlipidic Diet Induced Glomerular Morphometric Alterations and Renal Damage in Hypertensive Rats. R.O. Pereira, M.S. de Souza, I. Araujo, P. Fiorino, M. Fonteles, V. Farah. Federal University of São Paulo, Brazil and Mackenzie Presbyterian University, Brazil. C299 II 797.4 Gene Expression Data Analysis of High Fat Diet-Induced Obese Mice Following Treatment with a Putative Weight Loss Botanical Blend. J. Lu, A. Mastaloudis, Y. Ren, M. Bartlett. Nu Skin (China) Daily-use & Health Products Co. Ltd., People’s Republic of China, and Nu Skin Enterprises. C300 I 797.5 Safety and Efficacy of a Novel Green Coffee Bean Extract (GCB-70) in Overweight Subjects. D. Bagchi, N. Verma, M. Mittal, A. Swaroop, M. Bagchi, H.G. Preuss. Cepham Research Center, King George’s Medical University, India, Dr. Herbs LLC and Georgetown University Medical Center. C301 II 797.6 Female Wistar Han® Outbred Rats as a Model of Obesity When Fed High Fat Diets. J. Flowers, M.J. Horn. Envigo. C302 I 797.7 The Prevalence of Obesity and Metabolic Syndrome in Tibetan Immigrants Living in High altitude Area in Ladakh, India. B.Y. Lin, K. Genden, W. Shen, P. Wu, H. Hung, K. Yang, W. Lin. Syosset High School, Executive secretary of Tibetan Primary Health Care Center, India, Columbia University, National Taiwan University Hospital, Taiwan, National Taiwan University Hospital, Hsin-Chu Branch, Taiwan, National Taiwan University Hospital, Bei-Hu Branch, Taiwan, China Medical University University, Taiwan and China Medical University, Taiwan. C303 II 797.8 Daily Walnut Consumption Improves Metabolic Syndrome Status in Korean Adults. H. Park, E. Song, Y. Liu, Y. Song, H. Hwang, H. Kim. ICAN Nutrition Education and Research, Republic of Korea, Sookmyung Women’s University, Republic of Korea. C304 I 797.9 Can Bone Regulating Hormones and Nutrients Characterize the Metabolically Healthy Obese Phenotype? M. Cheung, K. Becker, S. Diamond, R. Duszak, L. McNamee, C. Wojciechowicz, A. Suresh, A. Aljahdali, M.C. Chenault, D. Sukumar. Drexel University and Drexel University College of Medicine. C305 II 797.10 BMI and Body Fat Mass Are Differentially Associated with fMRI Food-Cue Reactivity in Individuals with Obesity. W.R. Quarles, C.N. Kahathuduwa, T. Davis, M. O’Boyle, M. Binks. Texas Tech University and University of Peradeniya, Sri Lanka. C306 I 797.11 Self-Reported Stress Is Not Associated with Functional Magnetic Resonance Imaging FoodCue Reactivity in Adults with Obesity. W.R. Quarles, C.N. Kahathuduwa, T. Davis, M. O’Boyle, M. Binks. Texas Tech University and University of Peradeniya, Sri Lanka. C307 II 797.12 Influence of Age in Metabolic Syndrome Parameters Among College Students. H. Jenkins, W. Soule, D. Aguilar-Alvarez. Weber State University. C308 I 797.13 Ginger (Zingiber officinale) Extract Inhibits the Lipid Droplet Accumulation and Expression of Adipogenic Transcription Factors in 3T3-L1 Preadipocytes. H.J. Kim, E. Mun, J. Oh, Y. Cha. Chonbuk National University, Republic of Korea, Healthy Local Food Branding Agency, Republic of Korea.
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NUTRITION MONDAY C309 II 797.14 Perilla frutescens var Acuta Inhibits Differentiation of 3T3-L1 Preadipocytes by Downregulation of Lipogenic Pathway. S.S. Thomas, M. Kim, J. Ro, Y. Cha. Chonbuk National University, Republic of Korea, Hyunsung Vital Co., Ltd. Life & Science Research Center, Republic of Korea. C310 I 797.15 Daily Walnut Consumption Effects Lipid Profile and Body Protein in Korean Subjects with Metabolic Syndrome. E. Song, H. Park, Y. Liu, H. Kim. Sookmyung Women’s University, Republic of Korea, ICAN Nutrition Education and Research, Republic of Korea. C311 II 797.16 Deficiency of β, β-Carotene-9′, 10′-Oxygenase 2 Links to Systemic Inflammation, Dyslipidemia and Glucose Intolerance. L. Wu, X. Guo, Y. Lyu, S.L. Clarke, E.A. Lucas, B.J. Smith, W. Wang, D.M. Medeiros, X. Shen, D. Lin. Oklahoma State University, Nanjing University of Finance and Economics, People’s Republic of China, Kansas State University and University of Missouri-Kansas City. C312 I 797.17 Effect of a Mindful Eating Intervention on Weight Loss in Postmenopausal Breast Cancer Survivors—A Pilot Study. A.M. Washington, M. Davis, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, E.L. Sattler. University of Georgia. C313 II 797.18 Effect of a Mindful Eating Intervention on Lifestyle Factors in Overweight and Obese Postmenopausal Breast Cancer Survivors—A Pilot Study. K.A. Dunagan, A.M. Washington, M. Davis, H.N. Young, E. Cobran, D. Hartzell, E.L. Sattler. University of Georgia. C314 I 797.19 Low Manganese May Increase the Risk of Diabetes in Chinese Adults. L. Liu, S. Du, H. Wang, M.A. Mendez, B.M. Popkin. Beijing Municipal Center for Disease Control and Prevention, People’s Republic of China, The University of North Carolina at Chapel Hill, China Center for Disease Control and Prevention, People’s Republic of China. C315 II 797.20 Time Restricted Feeding of a High Fat Diet Protects Against Adiposity, but Not Liver Steatosis or Increased Systemic TNF-α Levels. L.B. Crone, R. Bloomer, M. Butawan, J. Wyman, J.L. Hill, A. Liu, H.W. Lee, M. van der Merwe. University of Memphis. C316 I 797.21 Glucocorticoids in Combination with a High Fat Diet Increase Acute Phase Proteins and Alters PUFA Metabolism in Visceral Adipose Tissue. J.L. Hill, J. Wyman, R. Buddington, M. van der Merwe. University of Memphis. C317 II 797.22 Beverage Patterns Are Associated with the Risk Factors of Obesity and Metabolic Syndrome in Korean Adults. K. Lee, D. Shin, W. Song. Michigan State University and University of North Dakota. C318 I 797.23 Evaluation of Dietary Intake and Red Blood Cell Membrane Fatty Acid Profile on the Incidence of Metabolic Syndrome in Hispanic Children from 2 to 10 Years of Age. A. Dysart, W.A. Clark, J.S. Marrs, J.M. Peterson, M.E. Johnson, A. Alamian. East Tennessee State University. C319 II 797.24 Reduced Risk Factors of Metabolic Syndrome in Immigrant Compared to Resident South Asian Indian Young Men. D.Q. Nguyen, D. Sukumar, K. Kanjana, A.Q. Victor, C. Pop, S. Shapses. Rutgers University, Drexel University and PSG College of Arts and Sciences, India.
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798. CARBOHYDRATE METABOLISM Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C320 I 798.1 Effects of Low Calorie Sweetener D-Psicose on Lipid Metabolism in Rats. J. Chen, W. Huang, B. Jiang. Jiangnan University, People’s Republic of China. C321 II 798.2 Gastrointestinal Tolerance of VERSAFIBE™ 2470 Dietary Fiber in Humans. M.L. Stewart, J. Zimmer. Ingredion Incorporated. C322 I 798.3 Post-Prandial Glycemic and Insulin Response to VERSAFIBE™ 2470 Dietary Fiber in Healthy Adults. M. Stewart, J. Zimmer. Ingredion Incorporated. C323 II 798.4 Effect of Polyphenols on Sugar Transport by GLUT2, GLUT5 and GLUT7. J. Gauer, S. Tumova, S. Gardner, A. Kerimi, J. Lippiat, L. McKeown, G. Williamson. University of Leeds, United Kingdom. C324 I 798.5 Modulating Postprandial Glycemic Response Through Inhibition of Potato Peel on Mucosal α-Glucosidase. C. Chen, H. Lin. University of Idaho. C325 II 798.6 A High Fiber Cookie Made with VERSAFIBE™ 1490 Dietary Fiber Reduces Post-Prandial Glucose and Insulin Responses in Healthy Adults. M.L. Stewart, J. Zimmer. Ingredion Incorporated. C326 I 798.7 Antidiabetic Effects of Water Extract and Fraction of Mori Cortex. K. Kim, M. Choe. Kangwon National University, Republic of Korea, Well-Being Bioproducts R&D Regional Innovation Center, Republic of Korea. C327 II 798.8 “Catalytic” Doses of Fructose and Its Epimers on Glycemic Control: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. J.C. Noronha, C. Braunstein, S. Blanco Mejia, A.I. Cozma, T. Khan, A. Glenn, R. Noseworthy, C.W C. Kendall, T.M. Wolever, L.A. Leiter, J.L. Sievenpiper. St. Michael’s Hospital, Canada, University of Toronto, Canada, St. Francis Xavier University, Canada and University of Saskatchewan, Canada. C328 I 798.9 Race/Ethnicity Evaluation of Postprandial Glycemic and Triglyceride Response. L. Zhu, D. Xiao, Y. Huang, I. Edirisinghe, B. Burton-Freeman. Illinois Institute of Technology. C329 II 798.10 Effects of Lentil Physical Form and Digestive Enzyme Availability on Postprandial Mood Responses. K.O. Anguah, W.W. Campbell, G.P. McCabe, M.A. McCrory. Louisiana Tech University, Purdue University and Boston University. C330 I 798.11 Acute Metabolic and Satiety Responses to Ingestion of Molasses Versus Sucrose in Healthy Adults. M. Kern, O. Orduna, T. Roberts. San Diego State University. C331 II 798.12 The Effect of “Catalytic” Doses of Fructose and Its Epimers in Acute Single-Meal Feeding Trials: A Systematic Review and Meta-Analysis of Controlled Trials. C.R. Braunstein, J.C. Noronha, S. Blanco Mejia, T.A. Kahn, T.M. Wolever, R.G. Josse, C.W. Kendall, J.L. Sievenpiper. St.Michael’s Hospital, Canada, University of Toronto, Canada and University of Saskatchewan, Canada.
MONDAY NUTRITION
799. APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM Poster (Sponsored by: Medical Nutrition Council) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C332 I 799.1 Chewing Rate Is Linked to Appetite and Hunger. E. Uǧur, R. Nergiz-Unal. Hacettepe University, Turkey. C333 II 799.2 Increased Physical Activity Ameliorates High Fat Diet-Induced Bone Resorption in Mice. J. Chen, O.P. Lazarenko, M.L. Blackburn, E. Carvalho, K. Shankar, E. Børsheim. Arkansas Children’s Nutrition Center and University of Arkansas for Medical Sciences. C334 I 799.3 The Effect of Combined Calcium and Vitamin D Supplementation on Premenstrual Symptoms and Depression. A.A. Yürük, F. Tamer, R. Nergiz-Unal. Hacettepe University, Turkey. C335 II 799.4 Effect of Ganjang (Korean Fermented Soy Sauce) on Renin-Angiotensin-Aldosterone System in Sprague-Dawley Rats. M. Kim, E. Mun, Y. Cha. Chonbuk National University, Republic of Korea. C336 I 799.5 The Effect of Meal Timing on Postprandial Glucose and Insulin Response in Healthy Volunteers. M. Bonham, G.K. Leung, C.E. Huggins. Monash University, Australia. C337 II 799.6 L-Carnitine Supplement and Running Training Improve Skeletal Muscle Recovery After Hindlimb Suspension Induced Muscle Atrophy. K. Lim, J. Jang. Konkuk University, Republic of Korea. C338 I 799.7 Lactate Co-Ingested with Caffeine Stimulates Fat Oxidation in Resting Mice. C. Yoo, J. Kim, H. Kim, Y. Hwang, E. Kim, Y. Park, K. Lim. Konkuk University, Republic of Korea. C339 II 799.8 Dairy, Dairy, Quite Contrary: Associations of Reported Dairy Consumption with Indices of Cardiovascular Health. E.S. Que, S. Krishnan, J. Waller, F. Lee, W.F. Horn, A. Vedula, J. Hall, L.C. Welch, K. Kishimura, N.L. Keim. USDA, University of California at Davis. C340 I 799.9 Increase in Serum Insulin, Urinary C-Peptide Immunoreactivity (CPR) Excretion Levels by Skimmed Milk Intakes Is Attenuated by Endurance Physical Exercise. T. Yamada, M. Okada, M. Matsuzaki, A. Tanaka. Kanto Gakuin University, Japan, Komazawa Women’s University, Japan and Kagawa Nutrition University, Japan. C341 II 799.10 The Improvement of Exercise Training on Diabetes-Damaged cAMP and Steroidogenesis Pathway in Leydig Cells of Streptozotocin-Induced Diabetes Rat. T. Lin, S. Tsai, C. Lu, C. Chen, C. Chen. University of Taipei, Taiwan, Mackay Junior College of Medicine, Nursing, and Management, Taiwan, Chang Gung University, Taiwan and National Yang-Ming University, Taiwan. C342 I 799.11 Dietary Factors Associated with High Fat Meal Challenge Based Metabolic Flexibility in Women with Metabolic Syndrome. S. Krishnan, E. Que, W. Justin, B. Gale, F. Lee, W.F. Horn, A.M. Vedula, J. Hall, L.C. Welch, K. Kishimura, N.L. Keim. UC Davis, USDA-WHNRC and UC Davis Medical Center.
C343 II 799.12 Positive Association Between Reduced GSH and Inadequacy/Deficiency of 25-Hydroxy-Vitamin D in Obese Children. S.K. Jain, R. Parsanathan, A.E. Achari. Louisiana State University Health Sciences Center. C344 I 799.13 Improvement of Exercise on DiabetesReduced LHR Sensitivity via Increasing Expression of StAR Protein. S. Chou, S. Tsai, C. Lu, C. Chen, C. Chen. University of Taipei, Taiwan, Mackay Junior College of Medicine, Nursing, and Management, Taiwan, Chang Gung University, Taiwan and National Yang-Ming University, Taiwan. C345 II 799.14 Effect of Carbohydrate Plus BranchedChain Amino Acids Supplementation on Hormonal and Inflammatory Responses During Normobaric Hypoxic Exercise. Y. Yang, C. Chen, C. Wu, C. Chen, C. Chou, J. Bernard, Y. Liao. National Taipei University of Nursing and Health Science, Taiwan, University of Taipei, Taiwan, National Taipei University of Technology, Taiwan and California State University at Stanislaus. C346 I 799.15 A Pilot Study to Assess Total Energy Expenditure in Children with Severe Burns During Acute Hospitalization: Application of the Doubly Labelled Water Method. E. Polychronopoulou, G. Singh, I. Malagaris, P. Craig, L. Sidossis, D. Herndon. Shriners Hospital for Children, UTMB and Rutgers University. C347 II 799.16 Physiological Changes in College Students While Taking Exams. M. Novak, A.E. Harris, S.A. Keuler, M.J. Rogatzki. University of Illinois at Chicago and University of Wisconsin-Platteville.
800. WATER AND FAT SOLUBLE VITAMINS AND CHRONIC DISEASE Poster (Sponsored by: Vitamins and Minerals RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C348 I 800.1 Supplementation Resulted in Lower Prevalence of Vitamin D Deficiency in Infants and Toddlers with Cystic Fibrosis Compared to That Reported for Healthy Children. L.H. Chin, H.J. Lai, F.R. Greer, . FIRST Study Group. University of Wisconsin-Madison. C349 II 800.2 Cyclodextrin-Based Nanocarriers for Alpha-Tocopheryl Phosphate and Regulatory Activity in THP1 Monocytes. J. Zingg, C. Stamatiou, S. Daunert. University of Miami. C350 I 800.3 Differential Uptake of RRR α-Tocopherol, All-Racemic α-Tocopherol, and RRR γ-Tocopherol Into Primary Human Aortic Smooth Muscle Cells. K.M. Ranard, M.J. Kuchan, C. Lai, J.W. Erdman. University of Illinois at UrbanaChampaign and Abbott Nutrition. C351 II 800.4 Effect of Housing Type on Vitamin D in Serum of Rhesus Monkeys. A.M. Preston, J. RodriguezOrengo, S. Ayala-Torres, E. Maldonado-Maldonado, L. Gonzalez-Sepulveda. University of Puerto Rico-Medical Science Campus, Puerto Rico, Caribbean Primate Research Center, Puerto Rico and Puerto Rico Clinical and Translational Research Consortium, Puerto Rico.
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NUTRITION MONDAY C352 I 800.5 Vitamin B-6 Is Negatively Associated with Oxidative Stress Independently of Homocysteine in Hemodialysis Patients. E. Yeh, Y. Huang, C. Chen. School of Nutrition, Chung Shan Medical University, Taiwan and Taichung Veterans General Hospital, Taiwan. C353 II 800.6 Evaluation of Vitamin E Intake in Korean Adults. Y. Kim, Y. Cho. Duksung Women’s University, Republic of Korea. C354 I 800.7 Vitamin D Supplementation Does Not Reduce Blood Pressure of Premenopausal African American Women. C.E. Moore, M. Ruppe. Texas Woman’s University and Houston Methodist Hospital. C355 II 800.8 The Effects of Vitamin D Supplementation on Glucolipid Metabolism and Pancreas and Muscle Histological Characteristic in Diabetic Rats. Q. Wang, A. Ma, J. Chi, X. Dou, Y. Liu, Y. Zhao. Nutrition Institute, Qingdao University, Qingdao, People’s Republic of China, Qingdao Chest Hospital, Qingdao, People’s Republic of China. C356 I 800.9 Effect of Vitamin D Intake Levels on Vitamin D Metabolism in High Fat Diet-Induced Obese Mice Compared to the Control. C. Park, S. Zhu, Y. Jung, S. Han. Seoul National University, Republic of Korea. C357 II 800.10 An Updated Approach for Extraction and Detection of Human Plasma Tocopherols and Tocotrienols. M S.H. Khan, L. Hao, C-L. Shen, S. Wang. Texas Tech University and Texas Tech University Health Sciences Center.
801. MICRONUTRIENT BIOAVAILABILITY AND ANTIOXIDANT FUNCTION Poster (Sponsored by: Vitamins and Minerals RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C358 I 801.1 Glutathione Concentration and Glutathione Peroxidase Activity Are Associated with the Risk of Liver Cirrhosis Independently of Oxidative Stress. Y. Huang, S. Cheng, H. Liu, C. Lai. Chung Shan Medical University, Taiwan and Taichung Veterans General Hospital, Taiwan. C359 II 801.2 Bioavailability of Carotenoids and Specific Vitamins of a Commercially Available Fruit-, Berryand Vegetable-Juice Concentrate. S. Dams, M. Lamprecht, S.J. Holasek, N. Meier-Allard, B. Poncza, Y. Jansenberger, D.E. Malliga. Green Beat—Institute of Nutrient Research and Sport Nutrition, Austria, Institute of Pathophysiology and Immunology, Medical University of Graz, Austria, Institute for Physiological Chemistry, Medical University of Graz, Austria, Division of Cardiac Surgery, Department of Surgery and Medical University of Graz, Austria. C360 I 801.3 Pharmacokinetics of Vitamin E Forms, Tocopherols and Tocotrienols, and Time-Dependent Formation of Their Metabolites in Rats. K.Y. Liu, Q. Jiang. Purdue University. C361 II 801.4 The Efficacy of Nano-Emulsification to Improve Vitamin D Bioaccessibility. A.S. Kadappan, C.E. Gumus, A. Bessey, D.J. McClements, R.J. Wood, Z. Liu. University of Massachusetts, Amherst and Tufts University.
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C362 I 801.5 Dose-Effect Relationship Between Dietary Iron and Hematological Parameters in Rats. K. Yokoi, A. Konomi. Seitoku University Graduate School, Japan and Kyushu Women’s University, Japan. C363 II 801.6 Parathyroid Hormone in Relation to Various Vitamin D Metabolites in Adult Females. N. Al-Daghri, S. Yakout, Y. Al-Saleh, N. Aljohani, O. Al-Attas, M. Alokail. King Saud University, Saudi Arabia, King Saud bin Abdulaziz University for Health and Sciences, Saudi Arabia and King Fahad Medical City, Saudi Arabia. C364 I 801.7 Slow Release of Iron Into Blood from Aspergillus oryzae Compared to Ferrous Sulfate in Humans. M.B. Reddy, S.M. Armah, Y. Bian. Iowa State University, University of North Carolina Greensboro, Cura Global Health and Inc. C365 II 801.8 Comparison of Digestion Methods for Phosphorus Analysis of Fecal and Diet Samples. C.J. Vorland, B.R. Martin, C.L H. Armstrong, J. Radcliffe, R.N. Moorthi, S.M. Moe, K.M. Hill Gallant. Purdue University and Indiana University School of Medicine.
802. ZINC, SELENIUM AND B VITAMINS Poster (Sponsored by: Vitamins and Minerals RIS) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C366 I 802.1 Gene Expression and Coordination of Cellular Zinc Transporters and Metallothioneins Are Altered in Type 2 Diabetes Mellitus. S. Samman, A. Chu, M. Foster, D.P. Hancock, P. Petocz. University of Otago, New Zealand, University of Sydney, Australia and Macquarie University, Australia. C367 II 802.2 Zinc and Copper Balances During Three Weeks of Bed Rest, with or Without an Artificial Gravity Countermeasure. H.N. Heacox, S.M. Smith, S.R. Zwart, P.L. Gillman. University of Central Arkansas, NASA Johnson Space Center, University of Texas Medical Branch and JES Tech. C368 I 802.3 Zinc Up-Regulates Nox1 Function by Increasing Mitochondrial ROS to Induce Senescence of Vascular Smooth Muscle Cells. J. Huang, R.G. Feresin, G. Salazar. Florida State University and University of Arkansas for Medical Sciences. C369 II 802.4 Effects of Hepcidin on Zinc Homeostasis in HepG2 Cells. A.M. Kelley, S.R. Hennigar, J.P. McClung. U.S. Army Research Institute of Environmental Medicine and Oak Ridge Institute for Science and Education. C370 I 802.5 Effects of Zinc Supplementation on Carnitine and Lactate Concentrations in Cultured Liver Cells. S. Barton-Wechsler, D.L. Stachura, E. Ho, L. Housley. California State University, Chico and Oregon State University. C371 II 802.6 Effect of Cooking and Malting on the Content and Bioaccessibility of Zinc and Folates in Quinoa (Chenopodium quinoa) and Amaranth (Amaranthus sp.). I.P. Castanheira, C. Motta, I.M. Delgado, A.C. Nascimento, A.S. Matos, G.B. Gonzales, M.C. Santos, C. Martins, R. Assunção, P.C. De Alvito. Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal, Faculdade de Ciências e Tecnologia, Portugal, Faculty of Bioscience Engineering and Ghent University, Belgium.
MONDAY NUTRITION C372 I 802.7 Effect of Marginal Zinc Intake and Repletion on Essential Fatty Acid Metabolism. J. Suh, S. Burke, M. Shigenaga, D. Killilea, T. Holland, S. Shenvi, B. Sutherland, J. King. Children’s Hospital and Research Center at Oakland and University of Iowa. C373 II 802.8 The Effect of Zinc Deficiency and Diet Restriction on GATA Family Gene Expression in Rat’s Kidney. A. Konomi, K. Yokoi. Kyushu Women’s University, Japan and Seitoku University, Japan. C374 I 802.9 ZIP10 Mediates Renal MT2 Production and Attenuates Oxidative Stress. S. Hao, G. Ding, H. Hao, P. Tian, S. Li, H. Zhao, Z. Darzynkiewicz, N.R. Ferreri. New York Medical College, National Institute for Nutrition and Health, China CDC, People’s Republic of China. C375 II 802.10 High-Density Lipoprotein Cholesterol Concentrations and Particle Size Are Modified by Dietary Zinc in Men. S. Shenvi, K. Chen, E. Kim, S. Zyba, S. King, M. Shigenaga, D. Killilea, T. Holland, B. Sutherland, R. Krauss, J. King. Children’s Hospital and Research Center at Oakland and University of Iowa. C376 I 802.11 ZIP14 (SLC39A14) Protects Against Muscle Atrophy and Attenuates Inflammatory Responses in Murine Skeletal Muscle. J. Kim, T.B. Aydemir, M. Kim, R.J. Cousins. University of Florida. C377 II 802.12 Regulation of Selenogenome, Selenoproteome, and Selenocystenine Biosynthesis and Degradation-Related Genes by a Novel Organic Se Compound in Avian Tissues. L. Sun, L. Zhao, M. Briens, S. Xu, X. Lei. Huazhong Agricultural University, People’s Republic of China, Adisseo France S.A.S., France, Northeast Agricultural University, People’s Republic of China, and Cornell University. C378 I 802.13 Selenoprotein K Functions to Promote Melanoma Progression and Metastasis. P. Hoffmann, M. Marciel, P. Kilicasian, A. Pham, F. Hoffmann. University of Hawaii and Mannheim Institute for Applied Sciences, Germany. C379 II 802.14 Selenium-Dependent Resolution of Inflammation in Macrophages Is Mediated Through Δ12PGJ2CRTH2 Signaling Axis. D. Bastihalli-Tukaramrao, S. Nettleford, K. Prabhu. The Pennsylvania State University. C380 I 802.15 Mechanistic Aspects of Selenium Delivery by Selenoprotein P. P. Copeland, S. Shetty. Rutgers— Robert Wood Johnson Medical School. C381 II 802.16 Selenoprotein T Positively Regulates α-Synuclein Expression and Cell Proliferation in SK-N-SH Cells. J. Zhu, H. Zhu, Z. Shao, S. Sun, X. Zhang. Wenzhou Medical University, People’s Republic of China. C382 I 802.17 Se and Zn Nutritional Status of Collegiate Female Athletes by Exercise Type. L. Okhee. Yongin University, Republic of Korea. C383 II 802.18 Regulation of the Stoichiometry of the Human Selenocysteine Synthase (SepSecS) Catalytic Complex. A.K. Puppala, M. Simonovic. University of Illinois at Chicago. C384 I 802.19 Minimum Selenium Requirements Based on Muscle and Kidney Glutathione Peroxidase Activity in the Turkey. R.M. Taylor, V.G. Bourget, R.A. Sunde. University of Wisconsin. C385 II 802.20 Dietary Excess Selenium Regulates the Transcription of Pancreatic Selenoproteome in Chicken. J.L. Li, W. Li, L.-R. Xiang, C.-Y. Cao, X.-Q. Jiang, S.-Y. Zhu. Northeast Agricultural University, People’s Republic of China. C386 I 802.21 Effects of Initial Selenium Status on Apparent Dietary Selenium Requirements in Rodents. R.A. Sunde. University of Wisconsin.
C387 II 802.22 Folic Acid and Riboflavin Deficiencies in Murine Macrophage RAW Cells Reduce LPS-Induced Nitric Oxide Production. M. Rittmann, J.W. Miller, A. Gow. Rutgers and The State University of New Jersey. C388 I 802.23 Modifications to Ascorbate Concentration and pH Result in Faster Deconjugation of Whole Blood Folate Polyglutamates to Monoglutamates for Measurement by Liquid Chromatography-Tandem Mass Spectrometry. R.A. Stamm, Z. Fazili, C.M. Pfeiffer. Centers for Disease Control and Prevention. C389 II 802.24 Folic Acid Intake Among U.S. Women of Childbearing Age with Suboptimal Red Blood Cell Folate Concentrations for Neural Tube Defect Prevention. Y. Qi, S. Tinker, R. Berry, K. Crider. CDC. C390 I 802.25 Whole Blood Stored at -70°C for 10 Years Appears to Provide the Comparable Stability to Folate Forms as Frozen Hemolysate with Ascorbic Acid. N. Paladugula, Z. Fazili, S. Jabbar, M. Zhang, C. Pfeiffer. Centers for Disease Control and Prevention. C391 II 802.26 Choline and Betaine Alter Fetal Brain Expression of Genes Related to Docosahexaenoic Acid Availability in a Mouse Model of Gestational Diabetes. Y. Joselit, C. Jack-Roberts, K. Axen, X. Jiang. Brooklyn College. C392 I 802.27 Profiles of Metabolic Protein Expressions in Proteomic and Phospho-Proteomic Analysis of Low Folate Modulates Energy Metabolism Bioenergetics in Colon Cancer. W-Y. Lan, W-C. Ku, R-F.S. Huang. Fu Jen Catholic University, New Taipei City, Taiwan. C393 II 802.28 Association Between One-Carbon Metabolism Indices and Dna Methylation Status in Maternal and Cord Blood. H. Park, A.K. Knight, J.M. Fleming, D.B. Hausman, M.A. Caudill, O.V. Malysheva, G.P. Kauwell, A. Sokolow, S. Fisher, A.K. Smith, L.B. Bailey. University of Georgia, Emory University, Cornell University, University of Florida, Athens Regional Midwifery Clinic and Emory University School of Medicine. C394 I 802.29 Changes in Blood Folate Concentrations in Response to Intake of Folic Acid—A Systematic Review and Meta-Analysis. K.S. Crider, O. Devine, Y. Qi, L. Yeung, A. Sekkarie, I. Zaganjor, R.J. Berry. CDC, Chestatee Solutions and Inc. C395 II 802.30 The MTHFR 677TT Variant Is Associated with Impaired Acute Blood Pressure Response to Sodium Ingestion. M.A. Murphy, P.A. Breslin, J.W. Miller. Rutgers University. C396 I 802.31 Relationships Among One-Carbon Nutrients Status, DNA Methylation at H19 Differentially Methylated Region and the Long Interspersed Nucleotide Elements, and Serum Insulin-Like Growth Factor Levels of Pregnant Women. K-T. Huang, Y-L. Shen, C-N. Lee, C-P. Cheng, W-C. Ku, R-F.S. Huang. Fu Jen University, Taiwan, Fu Jen Catholic University, Taiwan, and National Taiwan University Hospital, Taiwan.
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PATHOLOGY MONDAY
Pathology 803. LIVER HOMEOSTASIS, INJURY, AND REPAIR Poster
Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Liver Pathobiology
Liver Pathobiology
Cell and Tissue Injury
Inflammation
Presentation time: 11:45 am–1:45 pm
Presentation time: 11:45 am–1:45 pm
A1 803.1 Wnt/Beta-Catenin and mTOR Signaling in Liver Pathophysiology. A.O. Michael, T. Pradhan-Sundd, J. Russell, S.(. Monga. University of Pittsburgh. A2 803.2 Loss of MET in the Absence of EGFR Signaling Leads to Hepatic Failure in the Resting Liver. A. Tsagianni, W.M. Mars, W. Bowen, M. Haynes, S. Paranjpe, A. Orr, G. Michalopoulos. University of Pittsburgh School of Medicine. A3 803.3 Bile Acid-Mediated Accumulation of Brain Cholesterol Contributes to Hepatic Encephalopathy Due to Acute Liver Failure. S. DeMorrow, S. Grant, G. Frampton, M. McMillin. Central Texas Veterans Healthcare System and Texas A&M HSC College of Medicine. A4 803.4 The Role of Lipocalin-2 (Lcn2) in Acetaminophen Induced Acute Liver Failure. C. Paul, N. Gajjar, V. Bhave. Philadelphia College of Osteopathic Medicine. A5 803.5 Transcriptional Response in a Rat Model of Liver Ischemia-Reperfusion Injury. V. Zabala, P. Thevenot, A. Cohen, P.A. Gruppuso, J.A. Sanders. Brown University and Ochsner Health System. A6 803.6 Lack of β-Catenin in Hepatocytes Impairs Proliferation and Promotes Liver Progenitor Cell-Mediated Repair in Response to the Choline-Deficient EthionineSupplemented Diet. J.O. Russell, H. Okabe, S. Singh, M. Poddar, M. Abrams, K. Nejak-Bowen, S.P. Monga. University of Pittsburgh and Dicerna Pharmaceuticals. A7 803.7 Leukocyte Specific Protein-1 (LSP1) Functions as a Suppressor of Proliferation During Liver Regeneration After Partial Hepatectomy (PHx) and in Primary Hepatocytes. K. Koral, W. Bowen, M. Haynes, W. Mars, G. Michalopoulos. University of Pittsburgh. A8 803.8 Acceleration of Liver Regeneration by Betaine Supplementation After Partial Hepatectomy. D.S. Jun, Y.J. Choi, C.W. Ahn, Y.C. Kim. Seoul National University, Republic of Korea.
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804. PATHOBIOLOGY OF CHRONIC LIVER INJURY
A9 804.1 Up Regulation of Spleen Tyrosine Kinase in Ballooned Hepatocytes with Mallory-Denk Bodies in Alcoholic Liver Disease. N. Afifiyan, S. Samadzadeh, M. Masouminia, B. Tillman, B.A. French, S.W. French. Los Angeles Biomedical Research Institute and Harbor-UCLA Medical Center. A10 804.2 Role of Na+-K+-ATPase in Development of Alcoholic Fatty Liver Disease. H. Matsumoto, K. Sugimoto, S. Yang. Osaka University Graduate School of Medicine, Japan. A11 804.3 Characterization of Cellular Senescence Mechanisms in Alcoholic Liver Injury. F. Meng, S.R. Lorenzo, H. Francis, S. Glaser, G. Alpini. Baylor Scott & White Healthcare, Texas A&M HSC College of Medicine and Central Texas Veteran Healthcare System. A12 804.4 SREBP-1c Increases the Hepatic Inflammatory Response in Dairy Cows with Fatty Liver Through ROSMediated NF-κB Pathway. X. Li, G. Liu. Jilin University, People’s Republic of China. A13 804.5 Diagnosis of Naturally Occurring Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Rhesus Monkeys Using Dual-Energy CT (DECT) and Histopathology Criteria. F. Sun, Z. Liang, Z. Yang, C. Tang, Z. Chen, Y. Shen, Z. Yao, M. Wu, Y. Chen, F. Gao, W. Zeng, B.C. Hansen. Sichuan Primed Shines Bio-tech Co., Ltd, People’s Republic of China, Department of Radiology, Ya’an People’s Hospital, People’s Republic of China, Department of Radiology, West China Hospital, Sichuan University, People’s Republic of China, Department of Internal Medicine, Morsani College of Medicine, University of South Florida. A14 804.6 Mass Spectrometry Analysis of the Phosphoproteome in an in Vitro Lipotoxicity Model. R. Khachatoorian, W. Cohn, E. Ganapathy, N. Liu, J. Vu, N. Lu, J. Whitelegge, S.W. French. University of California at Los Angeles. A15 804.7 Mice Lacking Liver-Specific β-Catenin Develop Steatohepatitis and Fibrosis After Iron Overload. M. Preziosi, S. Singh, E. Valore, C. Jung, S. Nagarajan, T. Ganz, S. Monga. University of Pittsburgh and University of California at Los Angeles.
MONDAY PATHOLOGY A16 804.8 Wnt7b and Wnt10a, Beta-Catenin Independent Signaling Regulates Cholangiocyte Proliferation and Function During Cholestasis. K. Kosar, K. Nejak-Bowen. University of Pittsburgh School of Medicine. A17 804.9 Chronic Administration of Nicotine Increases Biliary Damage and Hepatic Fibrosis in Mdr2 Knockout (KO) Mice. A. O’Brien, L. Ehrlich, C. Hall, T. White, D. Dostal, G. Alpini, S. Glaser. Central Texas Veterans Foundation, Texas A&M Health Science Center, Baylor Scott & White Health and Central Texas Veterans Health Care System. A18 804.10 Integrin β6: Lost in Translation from Mouse to Human as a Target for Hepatic Fibrosis. C. Saravanan, Y. Song, P. Wu, W. Hu, F. Bian, A. Heidt, K. Mansfield. Novartis Institutes for Biomedical Research Institutes (NIBR), NIBR, People’s Republic of China, and The Genomics Institute of the Novartis Research Foundation. A19 804.11 YAP/TAX Regulate Hepatic Stellate Cell and Portal Fibroblast Proliferation After Hepatic Ischemia/ Reperfusion Injury. T. Konishi. University of Cincinnati. A20 804.12 The Inhibitory Effects of HJC0416 on Liver Fibrogenesis in Activated Hepatic Stellate Cells. O. NunezLopez, X. Wang, G. Graham, A. Kandathiparampil, N. Ye, H. Chen, H. Chen, J. Zhou, R.S. Radhakrishnan. University of Texas Medical Branch and Texas Tech University Health Sciences Center School of Medicine at Amarillo. A21 804.13 Thymosin Beta 4 Influences Hedgehog Signaling by Interacting with Smo-Gli2 in Hepatic Stellate Cells. J. Kim, Y. Jung. Pusan National University, Republic of Korea.
805. PATHOBIOLOGY OF HEPATIC TUMORS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Liver Pathobiology Neoplasia Presentation time: 11:45 am–1:45 pm A22 805.1 Proteomic Analysis of Focal Lesions in a Rat Model of Progenitor Marker-Positive Hepatocellular Carcinoma. A.O. Michael, N. Ahsan, H. Francois-Vaughan, V. Zabala, S. Post, K.E. Brilliant, A. Salomon, P. Gruppuso, J.A. Sanders. Brown University, University of Pittsburgh and Rhode Island Hospital. A23 805.2 Glypican 3 (GPC3)-CD81 Axis Regulates Spleen Tyrosine Kinase (Syk)-Ezrin Mediated Hippo Pathway via Cross Talking with HGF/c-Met Axis in Hepatocytes and Hepatocellular Carcinoma (HCC). Y. Xue, W. Bowen, K. Koral, A. Orr, W. Mars, G. Michalopoulos. University of Pittsburgh. A24 805.3 FGF19 Induced Hepatocarcinogenesis in Mice. J. Tao, S. Singh, X. Chen, p. Monga. University of Pittsburgh Medical Center and University of California San Francisco. A25 805.4 Thyroid Receptor Beta Agonist Reduces Tumor Burden in an Established Murine Model of Human Hepatocellular Cancer. Q. Min, E. Puliga, A. Columbano, S.S. Monga. University of Pittsburgh, Renmin Hospital of Wuhan University, People’s Republic of China, and University of Cagliari, Italy.
A26 805.5 Lipocalin 2 Is a Yap-Beta-Catenin Target and a Biomarker of Disease Burden in a Murine Model of Hepatoblastoma. D.E. Bell, J. Tao, M. Preziosi, T. Pradhan, S.P. Monga. Children’s Hospital of Pittsburgh and University of Pittsburgh. A27 805.6 Assessing the Role of Hepatocyte-Specific Wnts in Hepatocellular Carcinoma. M. Preziosi, S. Monga. University of Pittsburgh. A28 805.7 Understanding the Contribution of Macrophage-Specific Wnts to Hepatic Tumorigenesis and Cancer Progression. M. Preziosi, S. Monga. University of Pittsburgh.
806. CANCER AND MODIFIABLE RISK Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neoplasia Presentation time: 11:45 am–1:45 pm A29 806.1 Analysis of Thermography and Breast Cancer Prevention Among Minority Women and Other Ethnic Groups. K.M. New, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. A30 806.2 Alcohol Abuse Promotes Breast Cancer Development and Progression via StarD10 Phosphorylation. A. Floris, C. Cossu, Y. Spissu, M. Tomasi. Cedars-Sinai Medical Center. A31 806.3 Effects of High Fat Diet on 4-NQO-Induced Changes in a Variety of Tissues in a Mouse Model of Oral Cancer. J. Goral, A. Meyer, L. Pitstick, M. Pytynia, R. Schmelter, F. Syed, A. Barakat, D. Oswald, A. Gladding, J. Pescatore, J.M. Green, M.J. Ciancio, B. Jham. Midwestern University. A32 806.4 A High Fat Diet Augments 4NQO-Induced Oral Squamous Cell Carcinoma in Mice. M. Pytynia, A. Meyer, A. Nguyen, J. Goral, J.M. Green, B. Jham, L. Pitstick, M.J. Ciancio. Midwestern University. A33 806.5 C-Terminal Binding Protein and Snail: Understanding the Roles of Metabolic Imbalance and EMT in Breast Cancer Disparities. A. Jones, A. Caban-Ureña, S. Park, S. Gil-Hernández, J. Shin, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. A34 806.6 Exploring Molecular and Morphological Relationships Between Obesity and Ctbp in Breast Cancer. S. Park, T. Yan, L. Crawford, D. Li, A. Jones, A. Caban, S. GilHernandez, M. Kabbout, D. Yi, S. Ambs, V. Periwal, J. Byun, K. Gardner. NCI, NIMHD and NIDDK. A35 806.7 Ketogenic Therapies on Cancer Cachexia in a Mouse Model of Metastatic Cancer. A.P. Koutnik, A.M. Poff, N.P. Ward, J. DeBlasi, D.P. D’Agostino. USF.
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807. MOLECULAR TARGETS, BIOMARKERS, AND DISCOVERY IN NEOPLASIA Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neoplasia Presentation time: 11:45 am–1:45 pm A49 807.1 Nuclear Trafficking of ABCB1-Daunorubicin Vesicles Initiated by Sphingomyelinase Reverts Multidrug Resistance in Chinese Hamster Fibroblasts. W. Lee, R.N. Kolesnick. Witten/Herdecke University, Germany and Memorial Sloan-Kettering Cancer Center. A50 807.2 African Americans with Pancreatic Ductal Adenocarcinoma Exhibit Gender Differences in Kaiso Expression. A. Mukherjee, J. Jones, C. Yates. Troy University and Tuskegee University. A51 807.3 In Vitro Anticancer Efficacy of a Polyphenol Combination of Curcumin, Quercetin, Green Tea Extract and Resveratrol in Human Cervical Cancer HeLa Cells. M. Roomi, M. Rath, A. Niedzwiecki. Dr Rath Research Institute. A52 807.4 Oncogenic Activity of MAN2A1-FER Fusion in Liver Cancer and Other Human Malignancies. J. Luo, Z. Chen, S. Monga, G. Michalopoulos, Y.P. Yu. University of Pittsburgh. A53 807.5 Anti-Proliferative Properties of Methanolic Extracts of Annona muricata in Colon, Lung and Skin Cancer Cell Lines. J.F. Robles, K. Muñoz, N. Rivera, E. Suarez. University of Puerto Rico, Puerto Rico. A54 807.6 Aspirin Attenuates Melanoma Tumor Growth via PGF2α-SOX-2 Dependent Pathways. A. ThyagarajanSahu, R.P. Sahu. Wright State University. A55 807.7 Intrinsic Reactivation of Human Endogenous Retroviruses in the Osteosarcoma. S. Koks, G. Koks, X. Ho, K. Maasalu, A. Märtson. University of Tartu, Estonia. A56 807.8 Substituted Chalcones and Flavones as Human Monoamine Oxidase a (hMAO-A) Inhibitors with Prostate Cancer Antiproliferative Effects. N.O. Zarmouh, M. Gangapuram, S. Eyunni, F. Elshami, K.K. Redda, S.S. Messeha, K.F. Soliman. Florida A&M University. A57 807.9 Cervical Cancer and HPV: Dilemmas and Resolution via Biomarkers. D. Markovic, D. Markovic. Global Academy for Women’s Health, Inc. A58 807.10 Inhibition of CHOP Chemotherapy-Stimulated Hematological Tumor Growth with Resolvins. D. Fernandes, M. Gilligan, M. Kieran, S. Huang, C. Serhan, D. Panigrahy. Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute, Institute of Systems Biology and Brigham and Women’s Hospital. A59 807.11 Absence of Class a Scavenger Receptor Distinguishes a Phenotype of Tumor Associated Macrophages in Classic Hodgkin’s Lymphoma. Y. Yuan, E. Holthoff, J. Post, J. James, G.R. Post, S.R. Post. University of Arkansas for Medical Sciences. A60 807.12 Inhibition of Aggressive Natural Killer Cell Leukemia Cell Functions by Inhibitors of the Mevalonate Pathway and Its Products. W. Carlson, P. Pradhan, T. Steele. Des Moines University—College of Osteopathic Medicine.
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A61 807.13 Adjuvant Statin Therapy Efficacy Is Dictated by Tumor Dormancy and Statin Lipophilicity in ex Vivo and in Vivo Models of Metastatic Breast Cancer. C.H. Beckwitt, A.M. Clark, K. Warita, Z.N. Oltvai, A. Wells. University of Pittsburgh and Tottori University, Japan. A62 807.14 Characterization of Immunodeficient Mouse Models. J. McClellan, R. Macasocal, T. Hare, M. Horn. Envigo. A63 807.15 Optimization of Schwann Cell Differentiation from Porcine Stem Cells. D. Schomberg, D. Shanmuganayagam. University of Wisconsin-Madison. A64 807.16 Neuropilin Expression in Podocytes: The Implications for SEMA3 Anti-Cancer Therapy. E.N. Nzikoba, A. Zessler, X. Li, D. Briscoe, R.M. Adam, V. Schumacher, D.R. Bielenberg. Tufts University and Boston Children’s Hospital. A65 807.17 Molecular Diagnostic Techniques Used to Confirm an Unusual Case of BAPoma. A. Atkinson, K. Linos, S. Yan, G. Tsongalis, J. Lefferts. Dartmouth-Hitchcock Medical Center. A66 807.18 HLA-DR Positive Acute Promyelocytic Leukemia (APL). A.S. Mendoza, X. Qing, M. Dungo, J. Lasky, E. Panosyan, J. Cai. Harbor-UCLA Medical Center and Terasaki Research Institute. A67 807.19 Hemophagocytic Lymphohistiocytosis in a Patient with Legionella Infection and Bone Marrow Monotypic Plasma Cells in the Setting of Chronic Lymphocytic Leukemia. L. Nguyen, A. Ebaee, L. Pham, H. Ghani, S.W. French, X. Qing. Harbor-UCLA Medical Center. A68 807.20 Use of Anchored Multiplex PCR Enrichment for Detection of Gene Fusions in Solid Tumors by Next Generation Sequencing. D.C. Green, S.J. Deharvengt, F.B. de Abreu, H.B. Steinmetz, J.D. Peterson, G.J. Tsongalis. Dartmouth Hitchcock Medical Center, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center and Geisel School of Medicine.
808. TUMOR METASTASIS AND THE MICROENVIRONMENT Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neoplasia Tumor Microenvironment and Metastasis Presentation time: 11:45 am–1:45 pm A69 808.1 Molecular Analysis of the Blood-Tumor Barrier in Brain Metastasis from Breast Cancer. L. Lyle, R. Duchnowska, P. Lockman, C. Adkins, A. Shareef, E. Sechrest, E. Hua, D. Liewehr, S. Steinberg, W. Kloc, N. Nayyar, P. Brastianos, S. Patricia, B. Gril. National Cancer Institue, Purdue University, Military Institute of Medicine, Poland, West Virginia University, Copernicus Hospital Gdansk, Poland and Harvard Medical School. A70 808.2 Cathepsin K Cleavage of SDF-1α Inhibits Its Chemotactic Activity Toward Glioblastoma Stem-Like Cells in Their Niches. V. Hira, U. Verbovšek, B. Breznik, H. Kakar, J. Wormer, B. Van der Swaan, S. Mehta, T. Lah, C. Van Noorden. Academic Medical Center, Netherlands, Barrow Neurological Institute and National Institute of Biology, Slovenia.
MONDAY PATHOLOGY A71 808.3 Expression of Matricellular Protein CCN1 in the Tumor Stroma Is Required for Melanoma Metastasis. A. Leask, L. Postovit, K. Quensel, J. Hutchenreuther. Western University, Canada and University of Alberta, Canada. A72 808.4 Assessing the Effects of TIMP2 Knockout on Lung Cancer Cell Lines Cultured in 3D. D. Peeney. NCI. A73 808.5 Solute Carrier Family 2 Member 4 Regulates TRIM24-DDX58 Axis to Promote Head and Neck Cancer Metastasis. Y. Chang, M. Hsiao. Academia Sinica, Taiwan. A74 808.6 Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis. H. Qazi, Z-D. Shi, J.W. Song, L.M. Cancel, L.L. Munn, J.M. Tarbell. The City College of The City University of New York, Sloan-Kettering, The Ohio State University and Massachusetts General Hospital.
809. BREAST CANCER Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Breast Cancer Neoplasia Presentation time: 11:45 am–1:45 pm A75 809.1 3,4,2,4 Tetrahydroxychalcone (Butein) Inhibition of TNFα-Induced CCL2 Release in Triple Negative Breast Cancer Cells. A.C. Horton, D.F. Bauer, K.F. Soliman. Florida A&M University. A76 809.2 MiR-105/93-3p Promotes Metastasis, Chemoresistance and Stemness in TNBC and Circulating miR-105/93-3p Act as Predictive Biomarker for TNBC Chemoresistance. H. Li, P. Lu. National Cheng Kung University, Taiwan. A77 809.3 Apigenin Modulation of Whole Transcriptome Patterns of TNFα-Induced Changes in Triple Negative Breast Cancer Cells, MDA-MB-231. D. Bauer, E. Mazzio, K.F. Soliman. Florida A&M University. A78 809.4 Quercetin Inhibition of TNFα-Induced CCL28 Release from Human Triple Negative Breast Cancer (MDAMB-468) Cells. T.F. Buchanan, D. Bauer, K.F. Soliman. Florida A&M University. A79 809.5 Gradient Irradiation Enhances Cell Killing Efficiency via Bystander Effects in MCF-7 Cells. L. Zuo, T. Zhou. Ohio State University. A80 809.6 Glutamine Transporter Expression Profiling in Murine Breast Cancer Reveals Therapeutic Targets for Triple Negative Breast Cancer. C. Kron, B. Bode. Northern Illinois University.
A81 809.7 Internalization and Trafficking of PD-L1 in MDAMB231 Breast Cancer Cells. A. Rudkouskaya, M. Barroso. Albany Medical College. A82 809.8 Autophagy and Glutamine Synthetase Induction Sustain ALL Blast Resistance to L-Asparaginase in Human Bone Marrow Mesenchymal Stromal Cells. M. Chiu, D. Bardelli, G. Taurino, E. Dander, M.G. Bianchi, P. Mirandola, C. Carubbi, G. D’Amico, C. Rizzari, O. Bussolati. University of Parma, Italy, University of Milano-Bicocca, Italy, San Gerardo Hospital and University of Milano-Bicocca, Italy. A83 809.9 Exploring the Relationship Between Kaiso and C-Terminal Binding Protein in Breast Cancer in Women of African Ancestry. A.B. Caban-Ureña, A. Jones, J. Shin, S. Park, S. Gil-Hernández, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. A84 809.10 Induction of Paclitaxel Resistance in Human Breast Cancer Cell by JNK/SAPK-Inhibitory Kinase Through MAPK14/RELA/PTGS2 Signaling. T. Lai. Genomics Research Center and Academia Sinica, Taiwan. A85 809.11 Enlarged Endosomes and Altered Transferrin Recycling in Breast Cancer Cells. K.E. Tubbesing, A. Malhotra, A. Rudkouskaya, M. Barroso. Albany Medical College. A86 809.12 Hypoxia Stimulates an Increase of Neuropeptide Y Y1 and Y5 Receptor Expression in Human Breast Cancer Cells. P.J. Medeiros, J. Uniacke. University of Guelph, Canada. A87 809.13 Fatty Acid Desaturation and Triglyceride Accumulation Protects Breast Cancer Cells Against Fatostatin Induced Apoptosis. V. Brovkovych, J.M. Danes, I.T. Sakallioglu, G. Atilla-Gokcumen, J. Frasor. University of Illinois at Chicago and University at Buffalo. A88 809.14 Uncoupling Effects of ERα on LKB1/AMPK Signaling Induced by Adiponectin in Breast Cancer Cells. L. Mauro, G.D. Naimo, L. Gelsomino, E. Spina, M.L. Panno, S. Andò. University of Calabria, Italy. A89 809.15 Mangenese Superoxide Dismutase (MnSOD) Promotes Stem-Like Cell Phenotypes in Breast Cancer. C. He, P. Hart, K. Fricano, M. Vargas, K. Thieraud, A. Luelsdorf de Abreu, M. Bonini. University of Illinois at Chicago. A90 809.16 MED28 Regulates Proinflammatory CytokineInduced Epithelial–mesenchymal Transition and Invasion in Human Breast Cancer Cells. N. Hsieh, C. Huang, C. Li, Y. Weng, M. Lee. China Medical University, Taiwan and Chang Jung Christian University, Taiwan.
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Pharmacology 810. PHARMACOLOGY EDUCATION II Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Pharmacology Education Presentation time: 12:30 pm–2:30 pm D1 810.1 Actual and Potential Use of Information Technology in Pharmacology Education Among Medical Students in a Developing Country. H.O. Kwanashie. Ahmadu Bello University, Nigeria. D2 810.2 Effective Engagement of Large Numbers of Undergraduate Students in Pharmacology Practicals in Resource-Poor Settings: A Nigerian Experience. H.O. Kwanashie, T.O. Olurishe, J.I. Ejiofor, S.B. Anafi. Ahmadu Bello University, Nigeria. D3 810.3 Using Peer-Assisted Learning in a Pharmacology Undergraduate Research Program to Enhance Student Engagement and Performance. B.K. Kemp-Harper, G.R. Drummond, E.A. Davis. Monash University, Australia. D4 810.4 Student Attendance at Pharmacology Lectures and Its Relation to Exam Performance: A Two Year Observational Analysis. C.A. Powers, M.A. Carroll. New York Medical College. D5 810.5 Funding Success Following STEM Teacher Mentoring Drives Classroom Innovation. R. Rockhold, D. Sullivan, S. Bender. University of Mississippi Medical Center and Jim Hill High School.
811. THERAPEUTIC AND NONTHERAPEUTIC CANNABINOIDS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Presentation time: 12:30 pm–2:30 pm D6 811.1 Synthetic Cannabinoids: Rapidly Emerging Drugs of Abuse. A. Radominska-Pandya, J. Moran, W. Fantegrossi, P. Prather. University of Arkansas for Medical Science. D7 811.2 Rescue from Synthetic Cannabinoid Intoxication. B.C. Ginsburg. The University of Texas Health Science Center at San Antonio. D8 811.3 The Effects of THC on Brain Mitochondria of Zebrafish. O. Awodu, A.L. King. Kennesaw State University. D9 811.4 Methamphetamine Self-Administration History May Increase The reinforcing Effects of Cannabinoid Receptor Agonists in Rhesus Monkeys. M. Minkiewicz, W.S. John, M. Nader. Wake Forest Graduate School, Duke University and Wake Forest School of Medicine. D10 811.5 Evidence for Agonist-Specific Mechanisms of Cannabinoid Tolerance. C. Nealon, R. LaFleur, D. Morgan. Penn State College of Medicine.
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D11 811.6 The Anti-Migraine Effects of Delta-9Tetrahydrocannabinol in Female Rats Are Mediated by CB1 Receptors. R. Kandasamy, C.T. Dawson, A.T. Lee, M.M. Morgan. Washington State University and Washington State University Vancouver. D12 811.7 The Non-Psychoactive Phytocannabinoid, Cannabidiol (CBD), and the Synthetic Derivatives, HU308 and CBD-DMH, Reduce Hyperalgesia and Inflammation in a Mouse Model of Corneal Injury. D. Thapa, J.T. Toguri, A.M. Szczesniak, M.E. Kelly. Dalhousie University, Canada. D13 811.8 Effects of Cannabinoid Receptor Agonists on the Antinociceptive Effects of Oxycodone in Squirrel Monkeys. S.L. Withey, J. Bergman. McLean Hospital. D14 811.9 Persistent Potentiation of the Analgesic Effects of Opioids by Delta-9tetrahydrocannabinol (THC) in Nonhuman Primates. M.R. Nilges, P. Winsauer. Louisiana State University Health Sciences Center. D15 811.10 Effects of Morphine/CP55940 Mixtures on an Impulsive Choice Task in Rhesus Monkeys. V. Minervini, C.P. France. University of Texas Health Science Center at San Antonio.
812. NON-OPIOID APPROACHES TO PAIN Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Presentation time: 12:30 pm–2:30 pm D16 812.1 Anti-Nociceptive Effect of Chrysin in Partial Sciatic Nerve Ligation Model. D. Sujatha, N. Begum, P. KVSRG. Institute of Pharmaceutical Technology, India. D17 812.2 Effects of α7 Nicotinic Receptor Positive Allosteric Modulator on Sodium-Potassium-Chloride CoTransporter 1 Activation Following Lipopolysaccharide-Induced Neuroinflammatory Pain in Mice. S. Rahman, M. Abbas. South Dakota State University. D18 812.3 Highly Predictive Objective Measurement of OA Joint Pain in Rat Using Bioseb Automated Dynamic Weight Bearing System. H. Rashid, J. Cornicelli, A. Young, R. Samadfam. Charles River, Canada, Charles River and Charles River, United Kingdom. D19 812.4 Lasting Anti-Hyperalgesic Effect of Nanoemulsion Containing Essential Oil of H. pectinata in an Animal Model of Fibromyalgia. L.J. Quintans, J.S. Quinans, Z. Camargo, M.F. Arrigoni-Blank, R. Brito, M. Oliveira, M. Santos, A. Araújo, S.J. Kolker, K. Sluka. Federal University of Sergipe, Brazil and University of Iowa. D20 812.5 D-Limonene Complexed with β-Cyclodextrin Reduces Hyperalgesia in a Mice Model for Fibromyalgia. R.S. Barreto, P.S. Lima, H.G. Araujo, E.W. Pereira, M.M. Rezende, A.G. Guimaraes, A.S. Barreto, M.R. Santos, A.A. Araujo, L.J. Quintans-Junior, J.S. Quintans. Federal University of Sergipe, Brazil and State University of Feira de Santana, Brazil.
MONDAY PHARMACOLOGY D21 812.6 TRPV1 Mediates the Orofacial Antinociceptive Effect of Frutalin: in Vivo and in Silico Studies. A.R. Campos Barros, M.d. Damasceno, S.A. Santos, J.d. Melo Júnior, F.A. Magalhães, A. Vieira-Neto, R.d. Moreira, A.d. MonteiroMoreira. University of Fortaleza, Brazil, State University of Ceará, Brazil and Federal University of Ceará, Brazil. D22 812.7 Ca2+ Signaling Inhibitors Attenuate the Antinociceptive But Not Discriminative Stimulus Effects of the Imidazoline I2 Receptor Agonist 2-BFI in Rats. J.N. Siemian, Y. Zhang, J. Li. SUNY Buffalo and Research Triangle Institute. D23 812.8 A Comparative Study of Two Analgesic Compounds, Fenobam Sulfate and Fenobam Free Base, Using a Model of Inflammatory Nociception. A. Cox, N. Lax, W. Welsh, Y. Peng, B. Kolber. Department of Biological Sciences, Chronic Pain Research Consortium, Duquesne University, Rutgers Cancer Institute of New Jersey, Department of Pharmacology, Rutgers University, Rutgers Cancer Institute of New Jersey and Rutgers University. D24 812.9 Macrophage COX-2/mPGES-1/PGE2 Mediates Inflammatory Pain in Peripheral Tissues. l. Chen, G. Yang, T. Grosser. Advanced Institute for Medical Sciences, Dalian Medical University, People’s Republic of China, The Institute for Translational Medicine and Therapeutics and University of Pennsylvania. D25 812.10 Effect of Acute and Chronic Stress on Somatic Pain Sensitivity Under Circumstances of Indomethacin-Induced Gastrointestinal Injury in Conscious Rats. L. Filaretova, T. Bagaeva, N. Iarushkina. Pavlov Institute of Physiology, Russian Federation. D26 812.11 Use of PC-NSAIDs to Treat 2nd Degree Burn Injury in Rodent Models. L.M. Lichtenberger, K. Ono, T. Phan, D. Fang, B.J. Poindexter, R.J. Bick, E.J. Dial. The University of Texas Health Science Center. D27 812.12 ARHGEF10 Knockout Mice Exhibit AutismLike Behavior and Altered Pain Sensation. D. Lu, H. Liou, H. Liao, C. Chen, S. Gau, W. Fu. National Taiwan University, Taiwan and National Taiwan University Hospital and College of Medicine, Taiwan. D28 812.13 Analgesic Actions of Novel Derivatives of the Active Compound, Incarvillateine, from the Chinese Herb (Incarvillateine sinesis) in Acute Pain. A. Priebe, M. Hunke, M. Pattabiraman, S. Chandra. University of Nebraska-Kearney. D29 812.14 Beta-Cyclodextrin-Complexed with Lippia grata Leaves Essential Oil Reduces Hyperalgesia in Mice. J.S. Quintans, P. Siqueira-Lima, E.P. Menezes, H.G. Araújo Filho, A. Araujo, M.M. Rezende, R.L. Amarante, R.d. Barreto, A. Lucchese, L.J. Quintans-Júnior. Federal University of Sergipe/Brazil, Brazil, UEFS-Brazil, Brazil and UFS-Brazil, Brazil. D30 812.15 Differing Roles of S1P Receptor Adaptation in FTY720-Induced Antinociception in Acute Versus Neuropathic Pain. D.E. Selley, J.L. Wilkerson, S.P. Welch, G. Donvito, A.H. Lichtman, L.J. Sim-Selley. Virginia Commonwealth University. D31 812.16 Antinociceptive Effects of Novel GABAA Receptor Positive Allosteric Modulators in Mice: Pain-Stimulated and Pain-Depressed Behaviors. L. Lewter, J.M. Cook, J. Li. University at Buffalo and University of Wisconsin-Milwaukee.
813. NEUROPHARMACOLOGY AND NEUROPLASTICITY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D32 813.1 The Transition from Stochastic to Collective Activation of Nicotinic Acetylcholine Receptors Facilitates Information Transmission Within in Vitro Hippocampal Networks. S. Djemil, X. Chen, R. Dzakpasu. Georgetown University. D33 813.2 Effects of Brevetoxin and NMDA on Dendritic Arborization in Murine Organotypic Hippocampal Slice Culture. D. Gomez, T. Murray. Creighton University. D34 813.3 Cocaine as Opposed to Methamphetamine Did Not Restore Circadian Activity Rhythms in Arrhythmic Suprachiasmatic Nucleus Lesioned C3H/HeN Mice When Paired with Running Wheel. J.Y. Marrero Vega, S. Clough, M.L. Dubocovich. University at Buffalo. D35 813.4 Expression and Functional Characterization of PEA-15 Within the Suprachiasmatic Nucleus. K. Wheaton, L.S. Queiroz, K. Sullivan, K. Obrietan, K. Hoyt. OSU. D36 813.5 Light-Induced Changes in the Suprachiasmatic Nucleus Transcriptome Regulated by the MAPK/ERK Pathway. D.A. Correa, S. Aten, A. Garcia, K. Obrietan, K. Hoyt. OSU. D37 813.6 Evaluation of the Anticonvulsant Effects of Propofol in Pentylenetetrazole Kindled Rats. Z.A. Hasan. Arabian Gulf University, Bahrain. D38 813.7 Evaluating the Therapeutic Potential of Serotonin Modulators in Scn1a-Derived Epilepsy. J.C. Wong, K.S. Murnane, B.E. Blough, A. Escayg. Emory University, Mercer University and Research Triangle Institute. D39 813.8 Increasing KCC2 Function as a Strategy for the Treatment of Seizures. Y. Moore, T. Deeb, S. Moss. Tufts University. D40 813.9 Antidepressant-Like Effects of Ketamine in Serotonin Transporter Knockout Mice and Organic Cation Transporter 3 Knockout Mice. M.A. Bowman, M. Vitela, W.A. Owens, W. Koek, L. Daws. University of Texas Health Science Center San Antonio. D41 813.10 Pharmacologic Inhibition and Genetic Elimination of p38α MAPK Normalizes Serotonergic System Alterations and Social Behavior Deficits in the SERT Ala56 Mouse Model of Autism Spectrum Disorder. M.J. Robson, M.A. Quinlan, J. Veenstra-VanderWeele, D. Watterson, R.D. Blakely. Florida Atlantic University, Vanderbilt University, Columbia University and Northwestern University. D42 813.11 Conditional Deletion of L-Type Calcium Channels in Oligodendrocyte Progenitor Cells Affects Remyelination in Mice. D.A. Santiago Gonzalez, V.T. Cheli, V. Spreuer, P.M. Paez. University at Buffalo.
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814. NEURODEGENERATIVE DISEASES, ALZHEIMER’S, PARKINSON’S Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D43 814.1 The Study of Circulating Biomarker Panels in Early Diagnosis of Alzheimer’s Disease. W. Zhou, N. Jiang, C. Ruan, X. Cheng, Y. Zhang. Beijing Institute of Pharmacology and Toxicology, People’s Republic of China. D44 814.2 Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors (NMDARs) Shows Priority over Non-Selective NMDAR Antagonists Against Beta-Amyloid Induced Neurotoxicity. Y. Huang, W. Shen, G. Liu, W. Zhou, Y. Zhang. Beijing Institute of Pharmacology and Toxicology, People’s Republic of China. D45 814.3 The Effect of Sex on APOE-Modulated AD Pathology in EFAD Mice. M.E. Avila-Munoz, D. Balu, J. York, S. Ghura, N. Collins, M. Ladu. University of Illinois at Chicago. D46 814.4 Withdrawn. D47 814.5 The Effect of Aging on APOE-Modulated AD Pathology in EFAD Mice. D. Balu, A. Valencia-Olvera, N. Collins, R. Salzman, J. York, M. Ladu. University of Illinois at Chicago. D48 814.6 Rapamycin as a Novel Therapeutic for Alzheimer’s Disease: Prevention Assessed Through Neuroimaging. A.C. Wang, D.W. Ma, I. Parikh, V. Bakshi, J. Hoffman, S. Thalman, A. Lin. Sanders-Brown Center on Aging, University of Kentucky and University of Kentucky. D49 814.7 (-)-Epicatechin Mitigates Oxidative Stress, Neuroinflammation and Hyperphosphorylation of TAU in Hippocampus of Senile Mice. I. Ramirez-Sanchez, A. Rodriguez, T. Neri, P. Mendoza-Lorenzo, G. Ceballos, F. Villarreal. UCSD School of Medicine, Hospital Especialidades CMN SXXI, Mexico, UJAT, Mexico and IPN ESM, Mexico. D50 814.8 Study of Daily Genistein Ingestion on Spatial Memory and Olfaction in Triple Transgenic Alzheimer’s Mice. H.R. LeBlanc, A.C. Williamson, C.C. Wrenn. Drake University. D51 814.9 Zfra restores Memory Deficits in Alzheimer’s Disease Triple Transgenic Mice by Blocking Tau Aggregation and Amyloid Beta Formation. Y. Lin, Y. Shih, M. Lee, S. Lin, J. Chang, C. Sze, Y. Kuo, N. Chang. National Cheng Kung University College of Medicine, Taiwan. D52 814.10 Inhibition of Membrane-Induced AlphaSynuclein (aSyn) Aggregation: A Strategy to Interfere with Asyn Neurotoxicity in Parkinson’s Disease (PD). A. Chandran, D. Ysselstein, B. Dehay, I. Costantino, G.P. McCabe, M. Frosch, J.M. George, E. Bezard, J. Rochet. Purdue University, Institut des Maladies Neurodégénératives—Université de Bordeaux, France, Massachusetts Alzheimer’s Disease Research Center, Massachusetts General Hospital and Queen Mary University of London, United Kingdom. D53 814.11 ATP Exposure Increases Expression of α-Synuclein in Sh-Sy5y Cells: Potential Link Between Neuronal Injury and Parkinson’s Disease. J.T. Lamberts, D. Rustem, B. Wallis, C. Zwart. Ferris State University.
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D54 814.12 Microglial Kv1.3, a Voltage-Gated Potassium Channel, Mediates Neuroinflammation and Neurodegeneration in Cell Culture and Animal Models of Parkinson’s Disease. S. Sarkar, M. Langley, D. Harischandra, M. Neal, J. Luo, A. Charli, H.M. Ngyen, H. Jin, V. Ananthram, A. Kanthasamy, H. Wulff, A. Kanthasamy. Iowa State University, University of California at Davis.
815. NEUROTOXICITY AND NEURODEGENERATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D55 815.1 Fumaric Acid Esters as a New Therapeutic Target for Traumatic Brain Injury. E. Esposito, M. Campolo, G. Casili, R. D’Amico, M. Lanza, S. Cuzzocrea. University of Messina, Italy. D56 815.2 Co-Ultra PEALut Enhances Neuronal Recovery After a Moderate Traumatic Brain Injury. S. Cuzzocrea, I. Paterniti, M. Campolo, R. Crupi, A. Filippone, M. Cordaro, G. Bruschetta, E. Esposito. University of Messina, Italy. D57 815.3 Taurine Prevents the Neurotoxic Effects of Manganese on the Physiological Response of a Cilio-Inhibitory Dopaminergic System. E. Fatoke-Osobukola, K. Ernest, M.A. Carroll, E.J. Catapane. D58 815.4 The Neurotoxic Effect of Manganese on Dopamine Post-Synaptic Receptors Is Reversed by Taurine. K. Loney-Walsh, L. Dubose, E.J. Catapane, M.A. Carroll. D59 815.5 Downregulation of GRP78 Chaperone Protein Triggers Pro-Apoptotic CHOP Signaling Cascade in Acute Intracerebral Hemorrhage Rats. H. Liew, P. Chen, H. Peng, J. Chen, P. Lin, P. Wang, C. Pang, T. Chen. Tzu Chi General Hospital, Taiwan. D60 815.6 The Neuroprotective Role of Myeloid Zinc Finger-1 and Specificity Protein 1 During Treatment with Leukemia Inhibitory Factor. S. Davis, L. Collier, J. Fazal, M. Britton, C. Leonardo, C. Ajmo, K. Pennypacker. University of Kentucky and University of South Florida. D61 815.7 Erythropoietin Reverses Cognitive Deficits Following Infantile Traumatic Brain Injury: A Translational Touchscreen Investigation. L. Jantzie, S. Robinson. University of New Mexico and Johns Hopkins University. D62 815.8 Neonatal Erythropoietin Reverses Cognitive Deficits in a Preclinical Model of Encephalopathy of Prematurity. L. Jantzie, S. Robinson. University of New Mexico and Johns Hopkins University. D63 815.9 Oxytocin Protects Against Oxidative Stress and Apoptosis-Induced Cell Damage in Glial “U87-MG” CellLine: Role of OXT Receptor. M.M. Alanazi, T. Havranek, J. Bakos, A.M. Castejon. Nova Southeastern University, Institute of Experimental Endocrinology and Slovak Academy of Sciences, Slovakia. D64 815.10 Effect of Losartan on Acute Expression of Renin-Angiotensin System Genes in the Spinal Cord and Peripheral T-Cell CD11a Expression Following Spinal Cord Injury in Rats. E. Nguyen, T B. Jones, J. Leonard, D. Henery, C.B. Jones. Midwestern University.
MONDAY PHARMACOLOGY D65 815.11 Stroke Protection via Stimulation of Fatty Acid Oxidation Increases Astrocyte Spare Respiratory Capacity. M. Sifuentes, J. Lechleiter. University of Texas Health Science Center at San Antonio. D66 815.12 Neurosteroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model. P.A. Davies, A.A. Modgil, M. Parakala, M. Ackley, J. Doherty, S.J. Moss. Tufts School of Medicine, Sage Therapeutics and Inc. D67 815.13 Enhanced Mitochondrial Biogenesis for the Treatment of Spinal Cord Injury. N.E. Scholpa, A. Narang, W. Wang, D. Corum, S. Tomlinson, R.G. Schnellmann. University of Arizona and Medical University of South Carolina. D68 815.14 Erythropoietin Provides Neuroprotective Benefits Against Low-Dose Proton Exposure. S.E. King, T.L. DeWesse, P.G. Roma, R.D. Hienz, C.M. Davis. Johns Hopkins University School of Medicine, Washington & Jefferson College and Institutes for Behavior Resources. D69 815.15 Brevetoxin Induced Dendritic Arborization and Functional Recovery in a Murine Post-Stroke Model. E. Sequeira, M. Pierce, D. Gomez,T. Murray. Creighton University.
816. HETEROTRIMERIC G PROTEIN EFFECTOR PATHWAYS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D70 816.1 Domain-Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure. S.M. Schumacher, E. Gao, J. Chuprun, W.J. Koch. Lewis Katz School of Medicine at Temple University. D71 816.2 Identifying a Phospholipase C Epsilon Region That Interacts with Gbeta Gamma. J. Madukwe, S. Makik, A. Smrcka. University of Michigan and University of Rochester. D72 816.3 PLC-Dependent Hydrolysis of Phosphatidylinositol 4-Phosphate Is Responsible for the Majority of Total Inositol Phosphate Production and PKC/D Activation Downstream of Multiple GPCRs. R. Gil de Rubio, S. Malik, A.V. Smrcka. University of Rochester and University of Michigan. D73 816.4 Structural Studies of the RhoGEF Trio as a Target in Uveal Melanoma. S. Bandekar, B.L. Barton, E.S. Tully, J.JG. Tesmer. University of Michigan. D74 816.5 Discovery and Assessment of Chemical Probes Targeting Regulatory Surfaces of P-Rex1, a Metastatic RhoGEF. J.N. Cash, P. Sharma, M. Shost, E. Davis, J. Tesmer. University of Michigan. D75 816.6 Characterization of Rap1A-Dependent Activation of PLCε. M. Sieng, E.E. Garland-Kuntz, A.M. Lyon. Purdue University. D76 816.7 Electrostatic Regulation of Phospholipase C β. C. Esquina, N.Y. Rugema, E. Garland-Kuntz, A. Lyon. Purdue University. D77 816.8 Mechanisms and Regulation of PLCβ and Its Effects on Membrane Adsorption. B.N. Hudson, S. Hyun, D.H. Thompson, A.M. Lyon. Purdue University. D78 816.9 Structural Insights Into Phospholipase Cε: A Multi-Method Biophysical Approach. E.E. Garland-Kuntz, F.S. Vago, M. Sieng, S. Chakravarthy, W. Jiang, A.M. Lyon. Purdue University and Argonne National Laboratory.
D79 816.10 Differential Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling. J. Maning, K.A. McCrink, A. Brill, V. Desimine, B. Aukszi, A. Lymperopoulos. Nova Southeastern University.
817. KINASES AND PHOSPHATASES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D80 817.1 ERK1/2 Activation Following Renal Injury Is Required for Kidney Injury Molecule-1 Production. J.B. Collier, R. Whitaker, R.G. Schnellmann. Medical University of South Carolina and University of Arizona. D81 817.2 RhoA Regulates PINK1 Accumulation and Mitophagy Through PKD Activation. R. Tripathi, V.P. Tan-Sah, J.H. Brown, S. Miyamoto. Case Western Reserve University and University of California at San Diego. D82 817.3 Microtubule Affinity Regulating Kinase-2 Inhibition: Synthetic Peptide Mimetics of Human Tau Repeat Domains Reduce Tau Phosphorylation in Rat Primary Neurons. C.A. Qian, R.A. Colvin, N. Al Qaeisoom, J.A. Holub. Ohio University. D83 817.4 Structure-Based Design of Ikk&ε and Tbk1 Inhibitors for the Treatment of Obesity. T.S. Beyett, E. Labudde, J.J. Tesmer. University of Michigan. D84 817.5 Novel Regulation of IGF1R by Ubiquilin1. Z. Kurlawala, J. Gosney, B.P. Ceresa, L. Beverly. University of Louisville. D85 817.6 Inhibition of Heat Shock Protein 90 Reduces Opioid-Induced Anti-Nociception by Blocking ERK Mitogen Activated Protein Kinase Signaling in Mouse Brain. W. Lei, N. Mullen, C. Brann, J. Cormier, E. Bilsky, J.M. Streicher. University of Arizona and University of New England.
818. DRUG DISCOVERY AND DEVELOPMENT: DISCOVERY TECHNOLOGY PLATFORMS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Drug Discovery and Development Presentation time: 12:30 pm–2:30 pm D86 818.1 The Marine Pharmacology and Pharmaceuticals Pipeline in 2016. A.M. Mayer, M. Nguyen, P. Kalwajtys, H. Kerns, D.J. Newman, K.B. Glaser. Midwestern University, CCOM, Midwestern University, CCP, National Cancer Institute and AbbVie Inc. D87 818.2 Application of High Throughput Kinomics Analysis to Identify Inhibitors of Gemcitabine Resistant Pancreatic Cancer Growth. L.J. Krulikas, B. Lee, I.M. Macdonald, K.T. Gilbert, L.E. Herring, B.T. Golitz, C. Wells, A.D. Axtman, D.C. Morris, T. Willson, A.T. Baines, J. Yeh, G.L. Johnson, L.M. Graves. University of North Carolina at Chapel Hill and North Carolina Central University.
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PHARMACOLOGY MONDAY D88 818.3 Development of a Novel Single-Cell Assay to Interrogate a CRISPR/Cas9 Library for Regulators of MEK Kinase 2. K. Lotesto, B. Cuevas. Northeastern Illinois University and Loyola University Chicago. D89 818.4 Universal, Homogenous and Bioluminescent Assay to Monitor the Activity of Wide Range of Methyltransferases. S. Goueli, K. Hsiao. Promega Corp. and University of Wisconsin School of Medicine and Public Health. D90 818.5 A Multifaceted Approach to Improve Upon the Freshwater Cyanobacteria Drug Lead Discovery Pipeline. P. Sullivan, D. May, C. Crnkovic, J. Orjala. UIC. D91 818.6 Flow Cytometry-Based Quantification of Cyclic AMP in Primary Human Neutrophils. A. Chinn, A. Michkov, P.A. Insel, R. Corriden. University of California at San Diego. D92 818.7 A Novel One-Click Automated Drug Discovery Tool: A New Approach Based on Binding Efficiency Indices. P. Jabbarzadeh Kaboli, M. Bazrafkan, P. Ismail, K. Ling. Universiti Putra Malaysia, Malaysia and University of Padova, Italy. D93 818.8 mRNA Structural Modelling Predicts Variability in Efficacy of Post-Transcriptional Gene Silencing Between Species. A.J. Trujillo, J.M. Sullivan. University at Buffalo, University at Buffalo and VA WNY Health Center.
819. RENAL TOXICOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Toxicology Presentation time: 12:30 pm–2:30 pm D94 819.1 Exercise Preconditioning as a Means to Protect the Kidney Against Doxorubicin-Induced Oxidative Stress. I.M. Awwad, A.C. D’Lugos, C.C. Carroll, R.J. Gonzales, K.L. Sweazea, J.M. Dickinson, S.S. Angadi, T.M. Hale. University of Arizona, Arizona State University, Purdue University and Midwestern University. D95 819.2 The Role of DNA Methylation and Histone Acetylation in Bromate-Induced Alteration of p21 Expression in Human and Rat Kidney Cells. R.T. Kolli, S.P. Kaur, T.C. Glenn, B.S. Cummings. University of Georgia. D96 819.3 Quercitrin, a Natural Flavonoid Glycoside, Protects Against Cisplatin-Induced Injury in Rats Without Hindering Cisplatin Beneficial Cytotoxic Activity. E.A. Arafa, W. Mohamed, B. Shehata, H. Hassan, M. Raslan, G. Elsherbiny, A. Elgendy. Faculty of Pharmacy, Beni-Suef University, Egypt, College of Pharmacy, Ajman University, United Arab Emirates, Faculty of Pharmacy, Kafr El-Sheikh University, Egypt, Faculty of Veterinary Medicine and Beni-Seuf University, Egypt. D97 819.4 A Quantitative Morphometric Analysis of the Effects of Sub-Chronic Cadmium Exposure on the Proximal Tubule of the Rat. I. Hublikar, J.R. Edwards, P.C. Lamar, J.Z. Gasiorowski, W.C. Prozialeck. Midwestern University. D98 819.5 In Vitro Nephrotoxicity Induced by Dibromoanilines in Isolated Renal Cortical Cells from Male Fischer 344 Rats. G.O. Rankin, C. Tyree, B. Peters, J. Norwood, D. Anestis. Marshall University. D99 819.6 Resveratrol Protection of Mitochondrial Function in HK-2 Cells Exposed to Cisplatin. M. Valentovic, K. Brown, A. Lamyaithong, M. Dial. Marshall University School of Medicine.
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D100 819.7 Effect of Aqueous Extract and Anthocyanins of Calyces of Hibiscus sabdariffa L. (Malvaceae) in Rats with Adenine-Induced Chronic Kidney Disease. B.H. Ali, L. Cahliková, L. Opletal, T. Karaca, Y. Al Suleimani, M.H. Al Za’abi, A. Nemmar, G. Blunden. Sultan Qaboos University, Oman, Charles University, Czech Republic, University of Trakya, Turkey, UA University, United Arab Emirates and University of Portsmouth, United Kingdom. D101 819.8 Evaluating in Vitro Canine Kidney Slices as a Renal Toxicity Model Using Nephrotoxic Agents Cisplatin and Cadmium Chloride. K. Kowalkowski, M. Klapczynski, E. Blomme, W. Buck, M. Liguori. AbbVie. D102 819.9 The Potential Role of Acetaminophen and Alcohol in Early Stage Renal Disease: A Bayesian Perspective. H.T. Ndetan, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. D103 819.10 Cadmium Ion Upregulates the Activity of Human Organic Cation Transporter 2. H. Yang, D. Guo, Y. Shu. University of Maryland and Baltimore. D104 819.11 Derisking Renal Tubular Toxicity Identified During Early Compound Screening. S.R. Mantena, W. Buck, R. Peterson II, M. Liguori. Abbvie. D105 819.12 Identification of ROS-Induced Poly(ADPRibose)-Associated Proteins by LC-MS/MS. A. Islas-Robles, F. Munoz, S. Lau, T. Monks. University of Arizona, Wayne State University and Drexel University.
820. ASTHMA PHARMACOLOGY / TOXICOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Toxicology Presentation time: 12:30 pm–2:30 pm D106 820.1 Limonene Reduces Airway Hyperreactivity and Inflammation Through Activation of A2A Adenosine Receptors. D. Narke, M. Kurade, K. Dholakia, A. Siddique, N. Thakkar, K. Frey, D.S. Ponnoth. Long Island University. D107 820.2 Apelin Increases Airway Reactivity and Inflammation in a Mouse Model of Asthma. K. Dholakia, A. Siddique, M. Kurade, D. Narke, D.S. Ponnoth. Long Island University. D108 820.3 JTE-013, an Antagonist of Sphingosine 1-Phosphate Receptor 2, Inhibits Ovalbumin-Induced Allergic Asthma in Balb/c Mice. S. Park, S. Kang, D. Im. Pusan National University, Republic of Korea. D109 820.4 Anti-Inflammatory Effects of Serotonin 5-HT2A Receptor Activation in Ovalbumin-Induced Allergic Asthma Models. T.W. Flanagan, M.N. Sebastian, C.D. Nichols. Louisiana State University Health Sciences CenterNew Orleans. D110 820.5 The ‘Prophylactic’ and ‘Therapeutic’ Effects of β2-Adrenoceptor Blockers in a House Dust Mite (HDM) Driven Murine Asthma Model. R. Joshi, D. Valdez, H. Kim, B.J. Knoll, R.A. Bond. University of Houston. D111 820.6 Neurotransmitter Systems in Mouse Airways. C.M. Kieffer, Y. Tu, P.W. Abel. Creighton University.
MONDAY PHARMACOLOGY D112 820.7 Poly(ADP-Ribosyl)ation of Signal Transducer and Activator of Transcription (STAT)6 by Poly(ADP-Ribose) Polymerase (PARP)-1 Is Critical for Its Integrity and Subsequent Regulation of Th2 Cytokines During Asthma. J. Wang, M. Ghonim, S.V. Ibba, K. Pyakurel, M. Lammi, H. Boulares. LSU Health Sciences Center New Orleans and University of Milan, Italy. D113 820.8 Phosphatidylinositol-3,4,5-TrisphosphateDependent Rac Exchange Factor 1 (P-Rex1) Exacerbates Asthmatic Airway Smooth Muscle Cell Proliferation via Rac1Dependent Signal Pathways. Y. Huang, Y. Xie, H. Jiang, P.W. Abel, R.A. Panettieri Jr., T.B. Casale, Y. Tu. Creighton University School of Medicine, University of Pennsylvania and University of South Florida School of Medicine.
821. PHASE II DRUG METABOLISM Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D114 821.1 Aromatic Substitution Reaction of Ergothioneine—A Novel Mechanism of Xenobiotic Deactivation. C.G. Clerkin, M. Matzinger, M. Selo, B.N. Talbot, J.J. Walsh, C. Ehrhardt. Trinity College Dublin, Ireland and Kufa University, Iraq. D115 821.2 Characterization of UDP-Glycosyltransferase 3a (UGT3A) Variants in Tobacco Carcinogen Metabolism. A.G. Vergara, C.J. Watson, P. Lazarus. Washington State University. D116 821.3 Menthol Exhibits Stereospecific Inhibition of Phase II UGT Enzymes. S. Kozlovich, G. Chen, P. Lazarus. Washington State University—Spokane. D117 821.4 Human Fetal Sulfotransferase 1C4: Unique Properties and Novel Substrates. A.L. Guidry, M. RungeMorris, C.N. Falany. University of Alabama at Birmingham and Wayne State University. D118 821.5 In Vitro Inhibition of Human UGT Isoforms by Anti-HIV Boosting Drugs, Ritonavir and Cobicistat. N. Alam, S. Algeelani, A. Hossain, D. Greenblatt. Tufts University School of Medicine. D119 821.6 Expression and Regulation of SULT1C4 in Human Cells and Tissues. S. Dubaisi, H. Fang, T.A. Kocarek, M. Runge-Morris. Wayne State University. D120 821.7 Development and Characterization of SULT4A1 Mutant Mouse Models. P.L. Garcia, C.N. Falany. University of Alabama at Birmingham. D121 821.8 Identification of L-Asparagine as a Novel Endogenous Substrate for Human Arylamine N-Acetyltransferase 1. S.M. Carlisle, P.J. Trainor, D.W. Hein. University of Louisville.
822. PHARMACOKINETICS AND PHARMACODYNAMICS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D122 822.1 Physiologically Based Pharmacokinetic Model Verification and Improvement for Cyp2d6-Mediated DrugDrug Interaction Prediction. M. Ning, M.M. Posada, S.D. Hall, G.L. Dickinson. University of Illinois at Chicago and Eli Lilly and Company. D123 822.2 Stereochemistry of the Carbonyl Reduction of Msdc-0602, an Mtot-Modulating Insulin-Sensitizer for the Treatment of Nonalcoholic Steatohepatitis (Nash). W.J. Adams, T. Yousey, K. Bourdon, S. Talay, J.R. Colca. ADaMET Consulting LLC, Quintiles, Inc. and Metabolic Solution Development Company. D124 822.3 Alcohol Induced Changes in Cellular Pharmacokinetics and Pharmacodynamics of Elvitegravir and Darunavir in HIV-1 Infected Monocytic Cells. N.M. Midde, N. Sinha, Y. Gong, B. Meibohm, S. Kumar. University of Tennessee Health Science Center. D125 822.4 Ontogenic Expression of Key ADME Genes and Their Roles in Imatinib-Induced Toxicity in Juvenile Rats. Y. Wang. Soochow University, People’s Republic of China. D126 822.5 Effect of Moringa oleifera on the Pharmacokinetics and Pharmacodynamics of Pioglitazone. K. Bharathi, M. Sandhya, P. KVSRG. Institute of Pharmaceutical Technology, India. D127 822.6 Novel Polymer Micelle and Nanocrystal Formulations for the Proteasome Inhibitor Drug Carfilzomib: Pharmacokinetic and Pharmacodynamic Studies in Human Lung and Breast Cancer Models. J. Park, S. Chun, D. Reichel, J. Park, J. Min, G. Ryoo, Y. Oh, S. Bae, Y. Yeo, Y. Bae, W. Lee. Seoul National University, Republic of Korea, University of Kentucky, Purdue University, Catholic University of Korea, Republic of Korea. D128 822.7 Development of Novel Substrate Cocktail to Applicate in Vivo Drug-Drug Interaction Study. S. Kim, J. Jo, A. Na, S. Lee. University of Chicago and Kyungpook National University, Republic of Korea. D129 822.8 Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. J.L. Jilek, Y. Tian, A. Yu. University of California at Davis. D130 822.9 Hepatic Metabolism of Licochalcone A, a Chalcone from the Licorice Species Glycyrrhiza inflata. L. Huang, D. Nikolic, R.B. van Breemen. University of Illinois at Chicago. D131 822.10 Modeling the Metabolism and Subsequent Reactivity of Drugs. S. Swamidass, M. Matlock, N. Dang, T. Hughes, D.A. Barnette, G.P. Miller. Washington University and University of Arkansas for Medical Sciences. D132 822.11 Altered Irinotecan Pharmacokinetics During Inflammation in Mice. P. Chityala, S. Gao, M. Hu, R. Ghose. University of Houston. D133 822.12 Fructose Diet Decreases APAP-Induced Hepatotoxicity in Mice. A. Tripathi, S. Cho, G.E. Chlipala, S. Green, H. Jeong. University of Illinois Chicago.
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PHARMACOLOGY MONDAY D134 822.13 Potential for Drug Interaction of the Novel COMT Inhibitor Opicapone. A. Loureiro, C. Fernandes-Lopes, P. Soares-da-Silva. Bial, Portela e Companhia SA, Portugal and Institute of Pharmacology and Therapeutic, Portugal. D135 822.14 Determination of the P450- and UGTDependent Biotransformation of the Anti-HIV Drugs Cabotegravir and Dolutegravir. E. Madeen, N. Bumpus. Johns Hopkins University.
823. DRUG TARGETS IN CANCER Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D136 823.1 The Bacterial Quorum Sensing Molecule N-(3-Oxo-Acyl)Homoserine Lactone Inhibits Tumor Growth Independent of Bcl-2 Proteins. A.M. Neely, G. Zhao, C. Schwarzer, H. Lu, A.G. Whitt, N.S. Stivers, J.A. Burlison, T. Machen, C. Li. University of Louisville. D137 823.2 A Multidimensional FPLC Approach for the Purification of Recombinant Non-Coding RNAs. Z. Duan, P. Ho, J. Jilek, N. Batra, R. DeVere White, T. Wun, P. Lara, A. Yu. Biochemistry and Molecular Medicine, UC Davis School of Medicine, Cancer Center and UC Davis School of Medicine. D138 823.3 “Kill Two Birds with One Stone”: Bioengineering of Single RNA Molecule to Target miR-21a and Introduce miR34a in NSCLC Cells. H.E. Petrek, P. Ho, Z. Duan, N. Batra, J. Jilek, A. Yu. UC Davis School of Medicine. D139 823.4 Screening of a Small Flavonoid Library for AntiCancer Activity Against Glioblastoma. A.D. Faler, C.R. Stang, R.S. Khupse, R.A. Schneider. The University of Findlay. D140 823.5 Lipidomic Profiling Identifies Cytochrome P450 as a Therapeutic Target for Colitis-Associated Colorectal Cancer. W. Wang, J. Yang, M. Song, D. Wan, H. Yang, K. Sanidad, B.D. Hammock, H. Xiao, G. Zhang. University of Massachusetts, University of California at Davis. D141 823.6 The Interaction of GIV with Galpha-I Is a Druggable Protein-Protein Interaction. V. DiGiacomo, A.I. de Opakua, N. Merino, J.B. Blanco-Canosa, F.J. Blanco, M. Garcia-Marcos. Boston University School of Medicine, CIC-BioGune, Spain and Institute for Research in Biomedicine, Spain. D142 823.7 Targeting Mitochondrial Function and Biogenesis in KRAS-Dependent Pancreatic Cancer. A.M. Badejo, J. McCreary, E. Szlavich, H. True, A. Serrato, Q. Love, A. Malhotra. Pacific University. D143 823.8 Re-Purposing FDA-Approved Raloxifene to Target Apoptotic Proteins in KRAS-Mutant Pancreatic Cancer. A.M. Badejo, E. Szlavich, J. McCreary, H. True, A. Serrato, Q. Love, A. Malhotra. Pacific University. D144 823.9 Identification of Epigenetic Targets in the Treatment of Recurrent Breast Cancer. N.W. Mabe. Duke University. D145 823.10 Recombinant Human Tissue Inhibitor of Metalloprotease-2: A Novel Anti-Cancer Therapeutic. A. Chowdhury, B. Wei, Y. Yamada, N. Castro, D. Salomon, J.P. Schneider, W.G. Stetler-Stevenson. National Cancer Institute. D146 823.11 CCR1 as a Target for Metastatic Breast Cancer. M.D. Cao, Z. Zhang, A. Gilchrist. Midwestern University.
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D147 823.12 Targeting the Anaphase Promoting Complex to Prevent Lung Cancer Cell Growth. N.W. Wainscott, J. Hoffman, B. Taylor, J.O. Trent, J. States. University of Louisville. D148 823.13 Fluorescence Imaging Reveals a Potential Association of Laminin Receptor with SENP Machinery. M. Robinson, C.S. Umbaugh, M.L. Figueiredo. Purdue University. D149 823.14 Aggressive Breast Cancer Cell Line and Role of Translocator Protein. S. Mukherjee, C. Sharan, P. Mitra, S. Hari Gopal, S.K. Das. Meharry Medical College. D150 823.15 Rapid Progression of Breast Cancer Cell Proliferation in Diabetes: Role of Polyamines. M.J. Morwitzer, S. Chandra. University of Nebraska-Kearney. D151 823.16 Structure-Activity Relationship Studies of Oxypropanolamines: The Importance of Hydrophobicity About the Amine for Maintaining Anti-Proliferative Effects in Lung Cancer Cells. J. Hoffman, N.W. Wainscott, B.F. Taylor, J.A. Burlison, J.O. Trent, J. States. University of Louisville.
824. TUMOR MICROENVIRONMENT, ANGIOGENESIS, AND METASTASIS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cancer Pharmacology Presentation time: 12:30 pm–2:30 pm D152 824.1 Mechanisms of Jzu4Me, a Novel Inhibitor of Vascular Endothelial Growth Factor Induced Angiogenesis and Tumor Angiogenesis. S. Huang, T. Huang. Graduate Institute of Pharmacology, College of Medicine and National Taiwan University, Taiwan. D153 824.2 The Role of Microtubule-Associated Protein 3 in Angiogenesis. X. Yang, Y. Sun, U. Saqib, A. Banerjee, M. Geyer, V. Gaponenko, M. Rosenblatt, A. Malik, Y. Komarova. University of Illinois at Chicago. D154 824.3 Leading the Charge in Sprouting Angiogenesis: The Roles of PKA and PDE4D in Regulating Tip Cell Invasion. J. MacKeil, P. Brzesinska, J. Burke-Kleinman, D. Maurice. Queen’s University, Canada. D155 824.4 Memantine, the Dual α7-nAChR/NMDAR Antagonist Displays Potent Anti-Angiogenic Activity in Lung Cancer. Z.R. Robateau, K.C. Brown, Y.C. Chen, R.D. Egleton, P. Dasgupta. Joan C.Edwards School of Medicine and Alderson-Broaddus University. D156 824.5 Anti-Angiogenic Effects of Metformin in 2-Deoxyglucose Treated Microvascular Endothelial Cells: Role of Thrombospondin-1. S. Mathews Samuel, S. Ghosh, Y. Majeed, H. Ding, C.R. Triggle. Weill Cornell MedicineQatar, Qatar. D157 824.6 Opposite Angiogenic Outcome of Curcumin Against Ischemia and Lung Cancer: In Silico, in Vitro and in Vivo Studies. X. Li. School of Basic Medical Sciences, Peking University, People’s Republic of China. D158 824.7 Novel Role of Septin2 in Endothelial Cell Podosome Formation and Matrix Degradation. K.B. Collins, H. Kang, J. Klomp, A.B. Malik, A.V. Karginov. University of Illinois—Chicago. D159 824.8 In Vitro 3-Dimensional Modeling of Tumor Microenvironment Reveals Host/tumor Influence on Progression in Non-Small Cell Lung Carcinoma. D. Saforo, P.P. Shah, L.J. Beverly, L.J. Siskind. University of Louisville.
MONDAY PHARMACOLOGY D160 824.9 Action Analysis in Cell Migration of Tumour Cell Line MDA-MB 231. F.S. Guerra, R.G. Oliveira, C.A. Fraga, C.d. Mermelstein, P.D. Fernandes. UFRJ, Brazil. D161 824.10 Synthetic 8-Hydroxygdeoxyguanosine Paradoxically Inhibited Metastasis of Pancreatic Cancer Through Concerted Inhibitions of ERM and Rho-GTPase. Y. Han, J. Park, M. Chung, C. Kwon, K. Ko, K. Hahm. CHA Cancer Prevention Research Center, CHA Bio Complex, Republic of Korea, Lee Gil Ya Diabetes and Cancer Institute, Republic of Korea, CHA University Bundang Medical Center, Republic of Korea. D162 824.11 Capsaicin Suppresses the Metastasis of Human NSCLC in Vivo. N.A. Nolan, A.T. Akers, K.W. Colclough, J.D. Hurley, C.D. Williams, W.D. Rollyson, K.C. Brown, K.L. Denning, L.G. Brown, R.D. Egleton, P. Dasgupta. Joan C. Edwards School of Medicine and Marshall University. D163 824.12 A Dock-Derived PEDF Mimic Targeting Laminin Receptor Recapitulates PEDF Signaling. C.S. Umbaugh, A. Diaz-Quinones, M. Figueiredo. Purdue University and Universidad Central del Cariba Medical School. D164 824.13 Conjugated Bile Acids Promote Esophageal Adenocarcinoma Cell Invasive Growth via Activation of Sphingosine 1-Phosphate Receptor 2 and Sphingosine Kinase 2. R. Liu, X. Li, Y. Li, P.B. Hylemon, H. Zhou. McGuire VA Medical Center and Virginia Commonwealth University. D165 824.14 Combatting Colon Cancer Through Modulation of the Tumor Microenvironment and Gut Microbiota. J.K. Ko. Hong Kong Baptist University, Hong Kong.
825. CARDIOVASCULAR PATHOBIOLOGY OF INFLAMMASOMES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D166 825.1 Haptoglobin Prevents Atherosclerosis by Inflammation Regulation: A Prevention Role of Haptoglobin Hp for Atherosclerosis. T. Cheng, H. Chu, J. Pan. The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medica, Taiwan, The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taiwan, Division of Cardiology, Taiwan, School of Medicine and, Taiwan. D167 825.2 CCL18 as a Mediator of the Pro-Fibrotic Actions of M2 Macrophages in the Vessel Wall During Hypertension. C. Lewis, M. Zhu, M. Lieu, S. Moodley, Y. Wang, T. McConaghy, B. Larner, R. Widdop, C. Sobey, G. Drummond, B. KempHarper. Monash University, Australia. D168 825.3 Psychedelics as a New Anti-Inflammatory Therapeutic for Atherosclerosis. C.D. Nichols, M. Sebastian, T. Flanagan. LSU Health Sciences Center. D169 825.4 Distinct Roles of Extracellular Vesicles from Macrophages and Endothelial Cells in Regulation of Endothelial Inflammation. X. Lin, P. Zuo, G. Khanal, Y. Zhang, X. Li, Y. Zhang. University of Houston. D170 825.5 Arachidonic Acid Metabolites Induce TRPV1Mediated Inflammation. A.J. Hamers, A. Ahluwalia. William Harvey Research Institute, Barts & The London School of Medicine & Dentistry and Queen Mary University of London, United Kingdom.
D171 825.6 Nuclear PTEN Maintains Vascular Homeostasis by Stabilizing the Expression of ETS Transcription Factor, ERG. V. BR, T. Mohammad, M. Farazuddin, L. Yue, D. Mehta. University of Illinois at Chicago. D172 825.7 NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Crucial Role of the Cavernous Tissue Tone Modulation in Mice. R.S. Fais, F.L. Rodrigues, R.C. Tostes, F.S. Carneiro. Ribeirão Preto Medical School and University of Sao Paulo, Brazil. D173 825.8 Nicotine Induced Endothelial Dysfunction Through Cathepsin B-Dependent Activation of Endothelial Nlrp3 Inflammasome. Y. Chen, X. Li, P. Li,Y. Zhang. Guangzhou University of Chinese Medicine, People’s Republic of China, Virginia Commonwealth University and University of Houston. D174 825.9 Endothelial Caspase-11 Induces Endothelial Pyroptosis and Lung Vascular Injury. S. Xiong, K. Cheng, J. Rehman, A. Malik. University of Illinois College of Medicine. D175 825.10 RNA Receptor RIG-I Stimulation Impairs Endothelial Barrier Function Through Inflammasome Activation Independent of NLRP3. A.L. Pitzer, Y. Zhang, O. Bhat, P. Li. Virginia Commonwealth University and University of Houston. D176 825.11 Protective Role of Autophagy in NLRP3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries. O. Bhat, N. Meng, X. Yuan, H. Lohner, P. Li. Virginia Commonwealth University. D177 825.12 Endothelial NLRP3 Inflammasome Activation and Neointima Formation in Mice by Gut Microbial Metabolite Trimethylamine-N-Oxide. S. Koka, P. Li, Y. Zhang, K.M. Boini. University of Houston and Virginia Commonwealth University. D178 825.13 Macrophage-Derived Extracellular Vesicles Transfer Inflammasome Components to Endothelial Cells and Induces Endothelial Injury. P. Zuo, X. Lin, X. Li, Y. Zhang. University of Houston. D179 825.14 The Effect of MCPIP1 Deficiency on AgeRelated Lipid Profile Changes. C. Yang, E. Deaton, Y. Chang. A.T. Still University of Health Sciences. D180 825.15 Differential Effects of Short Chain Fatty Acids on Endothelial NLRP3 Inflammasome Activation and Neointima Formation. X. Yuan, L. Wang, O. Bhat, H. Lohner, Y. Zhang, P. Li. Virginia Commonwealth University and University of Houston.
826. VASCULAR SMOOTH MUSCLE CELLS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D181 826.1 Inhibitory Effects of Growth Differentiation Factor 11 on Phenotypic Transition Associated with Autophagy Deficiency in Mouse Coronary Arterial Myocytes. X. Yuan, O. Bhat, R. Lee, H. Lohner, Y. Zhang, P. Li. Virginia Commonwealth University and University of Houston. D182 826.2 Doxorubicin Dose Dependently Attenuates Cyclooxygenase-2 in Female Human Coronary Vascular Smooth Muscle Cells. T. Tat, M. So, N. Vijayavel, P. Raman, J.M. Dickinson, S.S. Angadi, R.J. Gonzales. University of Arizona, Arizona State University and Mayo Clinic.
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PHARMACOLOGY MONDAY D183 826.3 IGF-1 and Ang II Regulate Expression of the G Protein-Coupled Estrogen Receptor in Vascular Smooth Muscle Cells. J.L. Duong, S.H. Lindsey. Tulane University School of Medicine. D184 826.4 Expression and Characterization of Transcription Factor EB in Coronary Arterial Smooth Muscle Cells. R. Bao, P. Zuo, X. Li, P. Li, Y. Zhang. University of Houston and Virginia Commonwealth University. D185 826.5 Glucosamine Hydrochloride and Tunicamycin Attenuate Palmitate-Induced Glycosylation of Cyclooxygenase-2 in Primary Human Vascular Smooth Muscle Cells. P. Raman, T. Tat, R.J. Gonzales. University of Arizona. D186 826.6 PDE1C Regulates the Dynamics of ActinBased Structures in Migrating Human Arterial Smooth Muscle Cells. P. Brzezinska, D. Payne, S. Rampersad, J. Mackeil, J. Burke-Kleinman, D. Maurice. Queen’s University, Canada. D187 826.7 Inhibitory Effect and Mechanisms of Paroxetine, a Selective Serotonin Reuptake Blocker, on 5-HT-Induced Cell Proliferation and Migration of Vascular Smooth Muscle Cells. Y. Lin. Taipei Medical University, Taiwan.
827. GENERAL CARDIOVASCULAR PHARMACOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D188 827.1 Evidence That NaHs Inhibits the Tachycardic Responses Induced by Stimulation of the Preganglionic Sympathetic Outflow in Pithed Rats. D. Centurion, S.V. Castillo-Santiago, M.E. Becerril-Chacón, J.A. Torres-Perez, S. Huerta de la Cruz, A. Sanchez-Lopez. Cinvestav, Mexico. D189 827.2 Electrically Induced Cardioprotection via the Skin. A.E. Roessler, K. Luther, X. Ren, Y. Wang, Z. Shen, W.K. Jones. Loyola University Chicago. D190 827.3 Differential βarrestin1-Mediated Signaling in Spontaneously Hypertensive Versus Normotensive RatDerived Astrocytes. S. Negussie, A. Lymepropoulos, M. A. Clark. Nova Southeastern University and College of Pharmacy. D191 827.4 Amelioration by GABAB Receptors of the Cyclosporine-Evoked Counteraction of Endotoxic Cardiovascular Manifestations in Conscious Rats. M.Y. Sallam, S.M. El-Gowilly, A.A. Abdel-Galil, M.Y. Sallam, M.M. ElMas. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt, Faculty of Pharmacy and Alexandria University, Egypt. D192 827.5 Do Non-C1 Cells in the Rostral Ventrolateral Medulla Increase Blood Pressure? K.E. Dash, R.L. Stornetta, B.B. Holloway, P.G. Guyenet. University of Virginia and Hampton University. D193 827.6 Characterization of GPR40 as a Low Affinity Epoxyeicosatrienoic Acid (EET) Receptor in Vascular Cells. S. Park, A. Herrnreiter, S.L. Pfister, J.R. Falck, W.B. Campbell. Medical College of Wisconsin and University of Texas Southwestern Medical Center.
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D194 827.7 Ru(Bipyridine)2(Thiourea)(NO) Has Long Lasting Antihypertensive Effects in 2Kidney-1Clip and DahlSalt Sensitive Hypertensive Rats. N.R. Nascimento, P.B. Cabral, E.S. Sousa, L.F. Lopes, I.A. Paz, C.F. Santos, M.C. Fonteles. Ceara State University, Brazil, Federal University of Ceara, Brazil, Full Professor, Brazil and Ceara State University and Mackenzie University, Brazil. D195 827.8 The Role of PECAM-1 Mediated Signaling in Neutrophil Polarization. M.A. Khan, J. Shin, Y. Komarova, A. Malik. University of Illinois at Chicago. D196 827.9 Genetic Deficiency of Mas Receptor Impairs Vascular Repair by Bone Marrow Progenitor Cells. G. Vasam, S. Joshi, Y.P. Jarajapu. North Dakota State University. D197 827.10 Sirt1 Plays a Pivotal Role in TLR2-Mediated Mac-1 Expression in Monocytes. S. Lee. Pusan National University, Republic of Korea. D198 827.11 Droplet Digital PCR Reveals Substantial Tissue-Specific Differences in Estrogen Receptor Expression Profiles. D.D. Hutson, J.L. Duong, R. Sato, S.H. Lindsey. Tulane University School of Medicine. D199 827.12 Characterization of Acid Ceramidase and Its Regulation by HMGB1 in Mouse Coronary Arterial Myocytes. R. Lee, N. Meng, X.Yuan, P. Li. Virginia Commonwealth University. D200 827.13 Oroxylin-A Suppresses Adhesion Molecules Expression and Endothelial Barrier Disruption in Endotoxemic Arteries. T.-L. Tseng, M.-F. Chen, C.-H. Liu, Y.-H. Hsu, T.J. F. Lee. Dept of Medical Research, Buddhist Tzu Chi General Hospital, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan, Tzu Chi University, Taiwan and Southern Illinois University School of Medicine. D201 827.14 Interaction Between Sympathomimetic Amines, Norepinephrine, Tyramine and Dopamine at the Monoamine Transporter in Sympathetic Nerve Terminals and the Role of Nitric Oxide. J. Simaan. American University of Beirut, Lebanon. D202 827.15 Impact of Sex and GPER on the Cardiovascular Effects of the Environmental Estrogen Bisphenol A. H.M. Spooner, S.H. Lindsey. Tulane University School of Medicine. D203 827.16 Deactivation of 12-HETE by Peroxisomal β-Oxidation by Alternatively Activated Macrophages. T. Kriska, W.B. Campbell. Medical College of Wisconsin. D204 827.17 O-GlcNAc-eNOS Is Decreased in Blood Vessels from Pregnant Wistar Rats, but Not in Vessels from Pregnant SHR. J.A. Troiano, S. Potje, M. Graton, D.S. Silva, C. Antoniali. UNESP, Brazil. D205 827.18 Macrophage 12-HETE Enhances Angiotensin II Vasoconstriction Through Thromboxane B2 Release in Murine Aortas. T. Kriska, S.L. Pfister, W.B. Campbell. Medical College of Wisconsin. D206 827.19 Angiotensin Converting Enzyme-2 and Mas Receptor Are Hypoxia-Regulated in Human CD34+ Cells. S. Joshi, Y.P. Jarajapu. North Dakota State University. D207 827.20 Mechanisms Linking Chronic Obstructive Pulmonary Disease and Stroke. A.J. Bernard, J.M. Ku, S. Bozinovski, R. Vlahos, A.A. Miller. RMIT University, Australia.
MONDAY PHARMACOLOGY
828. APPROACHES IN PRE-CLINICAL PHARMACOLOGY I
829. APPROACHES IN PRE-CLINICAL PHARMACOLOGY II
Poster
Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Mon. 9:00 am—McCormick Place Convention Center, Hall F
Translational and Clinical Pharmacology
Translational and Clinical Pharmacology
Presentation time: 12:30 pm–2:30 pm
Presentation time: 12:30 pm–2:30 pm
D208 828.1 Exploration of Chemical Components Correlated with Pharmacology of EHYT Based on a LC-HRMS Metabolomics Approach. I. Ha, E. Kim, K. Kim. Kyung Hee Univ. Korean Medicine Hospital, Republic of Korea, College of Korean Medicine, Kyung Hee University, Republic of Korea. D209 828.2 Polyanionic Drugs Reduce Intracellular Bioavailability and Transfection Efficiency of Cationic siRNA Lipoplex: Quantitative Pharmacology Studies. P. Jaiprasart, B.Z. Yeung, Z. Lu, M.G. Wientjes, S. Woo, J.L. Au. University of Oklahoma Health Sciences Center, Optimum Therapeutics, LLC, Institute of Quantitative Systems Pharmacology and Taipei Medical University, Taiwan. D210 828.3 Validation of Click Chemistry with Mass Cytometry for Single Cell Analysis. J. Shaklee, K. Srivastava, H. Grundhofer, V. Pierre, J. van Berlo. University of MinnesotaTwin Cities. D211 828.4 Identification of Bioaminergic Lead Compounds to Treat Parasitic Blood Flukes (Schistosoma spp.) Through High Throughput Screening Natural Product Libraries. J.D. Chan, M. Johns, J.S. Marchant. University of Minnesota. D212 828.5 Development and Characterization of a Fluorescent Protein-Based Biosensor for the Detection of Extracellular ATP. J.M. Conley, S. Radhakrishnan, S.A. Valentino, M.C. Tantama. Purdue University. D213 828.6 Quantitative Pharmacology of Internalization, Intracellular Trafficking and Gene Silencing of siRNA. R.A. Abbiati, B.Z. Yeung, Z. Lu, G.M. Wientjes, J.L. Au. Institute of Quantitative Systems Pharmacology, Optimum Therapeutics LLC, Politecnico di Milano, Italy, Taipei Medical University, Taiwan and University of Oklahoma.
D214 829.1 Quantitative Pharmacology to Interrogate Mechanisms of Lipoplex Destabilization by Serum Proteins. R.A. Abbiati, B.Z. Yeung, P. Jaiprasart, Z. Lu, G.M. Wientjes, J.L. Au. Institute of Quantitative Systems Pharmacology, Optimum Therapeutics LLC, Politecnico di Milano, Italy, University of Oklahoma and Taipei Medical University, Taiwan. D215 829.2 Alternative Therapeutic Nanoparticle Approach for Treatment of Invasive Streptococcal Infections. T. Escajadillo, J. Olson, B. Luk, L. Zhang, V. Nizet. UCSD. D216 829.3 Method to Assess Interactivity of Drugs with Nonparallel Concentration-Effect Relationships. L. Zhao, J.L. Au, M.G. Wientjes. The Ohio State University, Optimum Therapeutics LLC, Taipei Medical University, Taiwan and University of Oklahoma Health Sciences Center. D217 829.4 Computational Approaches to Understanding ARB Resistance: A Route to Personalized ARB Therapy. S.D. Anderson, I. Nies, P. Santos, T. Soong, Y. Thu, W.M. BotelloSmith, Y. Luo, B.T. Andresen. Western University for Health Sciences, Rider University, Azusa Pacific University and Cal Poly Pomona. D218 829.5 Quantitative Pharmacology of Intercellular Drug Shuttle by Exosomes. J. Wang, M. Cui, B.Z. Yeung, Z. Lu, M.G. Wientjes, S. Woo, J.L. Au. Institute of Quantitative Systems Pharmacology, University of Oklahoma Health Science Center, Optimum Therapeutics LLC and Taipei Medical University, Taiwan. D219 829.6 Novel Three Dimensional and Dynamic (3DD) Cell Culture System for Optimization of Molecularly Targeted Combination Therapy in Dual HER2 and mTOR Refractory Breast Cancer. A. Ande, B.N. Tran, A. Brown, S. Ait-Oudhia. University of Florida. D220 829.7 Nanoparticle-Based Biosensors for the Detection of Lecithin:Cholesterol Acyltransferase Activity. R.U. Palekar, D. Kim, C.S. Thaxton. Northwestern University.
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Physiology 830. MICROVASCULAR DEVELOPMENT AND AGING Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E157 830.1 Aged Microvascular Networks Display Increased Pericyte Coverage Along Capillaries. A.D. SuarezMartinez, J.H. Lane, W.L. Murfee. Tulane University. E158 830.2 IGF-1 Deficiency Alters Hypertension Induced Cerebrovascular Remodeling in Mice. G.A. Fulop, F.I. RamirezPerez, S. Tarantini, V. Sjoelund, L.A. Martinez-Lemus, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research, University of Missouri and University of Oklahoma Health Sciences Center.
831. MICROVASCULAR FLOW REGULATION/ OXYGEN DELIVERY/NETWORKS Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E159 831.1 Inhibition of NOS Does Not Affect Oxygen Dependent Capillary Blood Flow Response in Vivo. G.M. Fraser, S. Milkovich, C.G. Ellis. Memorial University, Canada and Western University, Canada. E160 831.2 Phosphodiesterase 3 Inhibition Does Not Restore ATP Release from Deoxygenated Red Blood Cells of Older Adult Humans. M.L. Racine, M.J. Joyner, F.A. Dinenno. Colorado State University and Mayo Clinic. E161 831.3 Study of Systemic and Microvascular Responses to Progressive Hemolytic Anemia in Rats. W.H. Nugent, D.A. Carr, A. Ormond, S.P. Selwood, B.K. Song. Song Biotechnologies and SoBran Bioscience. E162 831.4 Comprehensive Geometric and Hemodynamic Analysis of Complete Microvascular Networks in Rat Gluteus Maximus Muscle: An Integrated Model Derived from Experimental Data. Z. Farid, K. Lemaster, M. Al Tarhuni, J.C. Frisbee, D.N. Jackson, D. Goldman. University of Western Ontario, Canada. E163 831.5 Peak Total-[Hemoglobin + Myoglobin] During Incremental Dynamic Handgrip Exercise and Post Occlusive Hyperemia. K.D. Didier, C.J. Ade, S.M. Hammer, T.J. Barstow. Kansas State University. E164 831.6 Impact of Early Mammalian Development on the Response of the O2 transport System to Muscle Contraction. S.C. Dodhy, R. Pittman. Virginia Commonwealth University. E165 831.7 Influence of Fan Induced Photoperiod on Selected Blood Physiological Variables of Male Broilers Reared to 63 Days of Age. H.A. Olanrewaju, J.L. Purswell, S.D. Collier, S.L. Branton. USDA.
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E166 831.8 Microvascular Perfusion Heterogeneity Impairs Oxygenation and Contributes to Peripheral Vascular Disease in Metabolic Syndrome. P. McClatchey, F. Woo, I. Olfert, C. Eliis, D. Goldman, J. Reusch, J. Frisbee. University of Colorado, Novartis, West Virginia University and University of Western Ontario, Canada. E167 831.9 Peri-Capillary Pericytes Are Associated with Capillary De-Recruitment in the Setting of Non-Critical Stenosis. C. Methner, J. Iliff, N. Alkayed, S. Kaul. Oregon Health and Science University. E168 831.10 Dynamics of Skeletal Muscle Microvascular and Interstitial PO2 from Rest to Contractions. D.M. Hirai, T.D. Colburn, J.C. Craig, T.I. Musch, D.C. Poole. Kansas State University. E169 831.11 Increased NO Sensitivity Is Associated with Maintained Coronary Microvascular cGMP-PDE5 Signaling in Exercising Swine with Multiple Co-Morbidities. R.W. van Drie, O. Sorop, J. van de Wouw, D. Merkus, D.J. Duncker. Erasmus MC, Netherlands. E170 831.12 Red Blood Cell ATP Release Correlates with Red Blood Cell Hemolysis. B.S. Ferguson, L.E. Neidert, M.J. Rogatzki, K.R. Lohse, L.B. Gladden, H.A. Kluess. University of Illinois at Chicago, Auburn University and University of Wisconsin—Platteville. E171 831.13 Evaluation of Smooth Muscle Cell Function in the Rat Mesentery Culture Model. J. Motherwell, M. Azimi, K. Spicer, N. Alves, J. Breslin, P. Katakam, W. Murfee. Tulane University and University of South Florida. E172 831.14 Oxygenation Characteristics of the Vastus Lateralis During Cycling Exercise Performed Above Critical Power. S.M. Hammer, A.M. Alexander, K.D. Didier, D.R. Baumfalk, T.J. Barstow. Kansas State University.
832. MICROVASCULAR MECHANICS/ HEMODYNAMICS/RHEOLOGY Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E173 832.1 Dependence of Erythrocyte Deformability on Mechanical Stress and Oxygenation. O. Yalcin, E. Ugurel, G. Saglam, A. Erten, A.C. Aksu. Koc University, Turkey. E174 832.2 Laminar Shear Stress Reduces NADPH Oxidase II Expression but Does Not Influence Superoxide Dismutase Expression in Human Adipose Microvascular Endothelial Cells. A.T. Robinson, M.D. Cook, M.D. Brown, S.A. Phillips. University of Delaware and University of Illinois at Chicago. E175 832.3 Localized Re and Radial Position Predicts Particle Flux at Microvascular Sized Branch Points. M. Frame, S. Darvishi. Stony Brook University.
MONDAY PHYSIOLOGY
833. MICROVASCULAR PATHOPHYSIOLOGYPHARMACOLOGY/THERAPEUTICS AND TRANSLATIONAL ASPECTS Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E176 833.1 Spironolactone Can Act on Pannexin1 Channels in Smooth Muscle Cells to Regulate Vasoconstriction and Blood Pressure. M.E. Good, I.K. Poon, Y. Chiu, J.T. Butcher, L.J. DeLalio, S. Mendu, I.Z. Jaffe, N. Leitinger, B.N. Desai, D.A. Bayliss, K.S. Ravichandran, B.E. Isakson. University of Virginia, La Trobe University, Australia and Tufts Medical Center. E177 833.2 Soluble Vimentin Binds to P-Selectin and Attenuates Leukocytic Infiltration Into the Lungs in Murine Endotoxin Induced Acute Lung Injury. F.W. Lam, Q. Da, B. Guillory, M. Cruz. Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center. E178 833.3 Age-Related Activation of ADAM17/TNF in Adipose Tissue Leads to Remote Coronary Microvascular Dysfunction in Obese Patients. H. Dou, A.C. Davila, V. Patel, D. Fulton, N. Weintraub, Z. Bagi. Augusta University. E179 833.4 Impaired Conducted Coronary Arteriole Dilation in Patients with HFpEF. A.C. Davila, H. Dou, V. Patel, D. Fulton, N. Weintraub, Z. Bagi. Medical College of Georgia and Augusta University. E180 833.5 Is Heart Failure a Coronary Microvascular Disease? L. Rinker, L. Yin, T. Hakobyan, M. Enrick, C. Kolz, N. Nadler, J. Chao, D. Sim, P. Hopman, W. Chilian, V. Ohanyan. Northeast Ohio Medical University. E181 833.6 Beneficial Pleiotropic Anti-Depressive Effects of Cardiovascular Disease Risk Factor Interventions in Metabolic Syndrome. J. Frisbee, S. Stranges, A. Duncan, S. Frisbee. University of Western Ontario, Canada. E182 833.7 Determining eNOS Binding and Circulation Modulating Effects of an Alpha Globin Mimetic Peptide (HbαX). T. Keller IV, J.T. Butcher, N.K. Swope, L. Columbus, B.E. Isakson. University of Virginia. E183 833.8 Adipose Stromal Vascular Fraction Cells Improve Coronary and Cardiac Physiology in the Aged Female Heart. J. Beare, C. Shofner, J. Dale, J. Tinney, B. Keller, J. Hoying, A. LeBlanc. University of Louisville. E184 833.9 Hypoxia Disturbs the Metformin-Evoked Curtailment of Chemokine CX3CL1 (Fractalkine) Signaling in Human Umbilical Vein Endothelial Cells (HUVECs). D. Szukiewicz, M. Pyzlak, G. Szewczyk, J. Wejman, J. Kochanowski. Medical University of Warsaw, Poland. E185 833.10 Protease Inhibition to Optimize the Intestinal Mucosal Barrier to Digestive Enzymes During Hemorrhagic Shock. F.A. DeLano, H. Zhang, G.W. Schmid-Schönbein. University of California at San Diego.
E186 833.11 Effects of Long-Term Administration of the KCa Channel Agonist SKA-31 on Cardiovascular Function in the Type 2 Diabetic Goto-Kakizaki Rat. R.C. Mishra, C.M. John, D.J. Kendrick, P.W. Fedak, H. Wulff, A.P. Braun. University of Calgary, Canada and UC Davis. E187 833.12 Amiloride Reduces ENaC Content and Enhances Endothelial Dependent Dilation in Mesenteric Arteries of Female Mice Fed a Western Diet. K.D. Marshall, A.R. Aroor, F.I. Ramirez-Perez, J. Habibi, V.G. DeMarco, G. Jia, M. Garro, A. Whaley-Connell, R. Nistala, J.R. Sowers, L.A. Martinez-Lemus. University of Missouri and Harry S. Truman Memorial Veterans’ Hospital.
834. PERMEABILITY/FLUID AND SOLUTE EXCHANGE/GLYCOCALYX Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E188 834.1 ADAM15-Mediated Glycocalyx Injury Contributes to Vascular Barrier Dysfunction During Inflammation. X. Yang, J.E. Meegan, M. Jannaway, S.Y. Yuan. University of South Florida. E189 834.2 Direct Current Stimulation of Endothelial Monolayers Induces a Transient and Reversible Increase in Transport due to the Electroosmotic Effect. L.M. Cancel, K. Arias, M. Bikson, J. Tarbell. The City College of New York. E190 834.3 A Tri-Phasic Role for Hydrogen Peroxide in Blood-Brain Barrier Endothelial Cells. C. Anasooya Shaji, B. Robinson, A. Yeager, M. Beeram, C.L. Isbell, B. Tharakan. Baylor Scott and White Health & Texas A&M University College of Medicine and Texas Bioscience Institute. E191 834.4 Sphingosine-1-Phosphate Protects Endothelial Cells and Microvascular Barrier Function Following Hypoxic Injury and Hemorrhagic Shock. N.G. Alves, S.Y. Yuan, J.W. Breslin. University of South Florida. E192 834.5 Hyperglycemia-Induced Ubiquitination and Degradation of β-Catenin with the Loss of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) in Retinal Endothelial Cells. R. Eshaq, N. Harris. LSU Health-Shreveport. E193 834.6 Sphingosine-1-Phosphate Reduces Adhesion of Malignant Mammary Tumor Cells MDA-MB-231 to Microvessel Walls by Protecting Endothelial Surface Glycocalyx. B. Fu, L. Zhang, M. Zeng. The City College of the City University of New York. E194 834.7 Inflammation-Induced Syndecan Shedding Contributes to Endothelial Barrier Dysfunction. M. Jannaway, X. Yang, J.E. Meegan, S.Y. Yuan. University of South Florida. E195 834.8 Modulation of P2Y2R-Dependent Vascular Barrier Function: Focal Adhesion Kinase. J. Wang, J. Harvey, R. Garrad, L. Erb, G. Weisman, V. Huxley. Missouri State University, University of Washington, St. Louis and University of Missouri-Columbia.
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835. VASOMOTOR CONTROL: ENDOTHELIUM/ SMOOTH MUSCLE/NERVES Poster (Sponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E196 835.1 Endothelium-Dependent Agonists Interact to Augment Vasodilation and Limit α1-Adrenergic Vasoconstriction in Humans. J.D. Terwoord, M.L. Racine, C.M. Hearon Jr., G.J. Luckasen, F.A. Dinenno. Colorado State University, Medical Center of the Rockies Foundation and University of Colorado Health. E197 835.2 Amyloid Beta Peptides and Inflammatory Cytokines Depress Human Brain Vascular Smooth Muscle Tonic Contractility: Relevance to Alzheimer’s Disease Impaired Cerebral Autoregulation. J. Yun, C. Washington, A. Minagar, J. Alexander. Louisiana State University Health Sciences Center- Shreveport. E198 835.3 KATP Channels Mediate CGRP-Dependent Hyperpolarization of Mouse Pulmonary Artery Smooth Muscle and Endothelium. C.E. Norton, S.S. Segal. University of Missouri and Dalton Cardiovascular Research Center. E199 835.4 Vasoactivity of the Vasculature Directly Supplying the Rat Sciatic Nerve. E. Williams, A.T. Klein, D.N. Jackson, J. Twynstra. Brescia University College, Canada and The University of Western Ontario, Canada. E200 835.5 PIP2-Regulation of Endothelial KIR2.1 Channels in Cerebral Arteries. M. Sancho, D.G. Welsh. University of Western Ontario, Canada. E201 835.6 The Role of NADPH Oxidase in Regulating Cerebral Vascular Myogenic Tone. N. Mazumdar, H. Jalali, A.M. Hashad, D.G. Welsh. University of Western Ontario, Canada and University of Calgary, Canada. E202 835.7 Altered Distribution of Adrenergic Constrictor Responses Contributes to Skeletal Muscle Perfusion Abnormalities in Metabolic Syndrome. K. Lemaster, D. Jackson, D. Welsh, S. Brooks, P. Chantler, J. Frisbee. University of Western Ontario, Canada and West Virginia University. E203 835.8 Effect of Aging on Vascular Smooth Muscle Contractility in Skeletal Muscle Resistance Arteries. C. Woodman, J. Seawright, S. Shin, A. Trache. Texas A&M University. E204 835.9 Exercise-Like Mechanical Stimulation Improves Myogenic Responses in Aged Skeletal Muscle Resistance Arteries. S. Shin, J. Seawright, A. Trache, C. Woodman. Texas A&M University. E205 835.10 Water Extract of Imperatae Rhizom Induces Vascular Relaxation Via No-Cgmp-Pkg Signaling. H. Kim, Y. Ahn, X. Jin, M. Hong, H. Kim, S. Yang, Y. Lee, H. Lee, D. Kang. Wonkwang University, Republic of Korea. E206 835.11 Ojeoksan Suppressed TNF-α-Induced Vascular Inflammation in Human Umbilical Vein Endothelial Cells. B. Han, H. Kim, Y. Ahn, X. Jin, D. Jeong, Y. Lee, H. Lee, D. Kang. Wonkwang University, Republic of Korea. E207 835.12 Ligustilide Activates NRF2/HO-1 Induction, NO Synthesis and Ameliorates Vascular Inflammation in HUVECS. E. Choi, J. Yoon, S. Namgung, D. Jeong, H. Kim, Y. Lee, D. Kang, H. Lee. Wonkwang University, Republic of Korea.
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E208 835.13 Mechanisms of Vasodilatory Effects of Total Flavonoids from Euphorbia humifusa in Rat Aorta. X. Ji, B. Wu, Z. Zhou, D. Kang, H. Lee, K. Cho, S. Jin, J. Wen. Taishan Medical University, People’s Republic of China, Wonkwang University, Republic of Korea. E209 835.14 The Functional Contribution of Myoendothelial Feedback to Arterial Tone Is Determined by the Nature of the Vasoconstricion. P.M. Kerr, R. Wei, S.E. Lunn, S.L. Gust, B. Classen, T.V. Murphy, S.L. Sandow, F. Plane. Macewan University, Canada, University of Alberta, Canada, UNSW, Australia and University of the Sunshine Coast, Australia. E210 835.15 Myogenic Oscillations During Alpha-2 Agonist Administration in Humans. P.O. Talke, M. Diab. UCSF and Masimo.
836. CONTROL OF BLOOD FLOW Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E211 836.1 Presence of Hysteresis in the Cerebral Pressure-Flow Relationship During Repeated Squat-Stand Maneuvers in Humans. P. Brassard, H. Ferland-Dutil, J.D. Smirl, M. Paquette, O. Le Blanc, S. Malenfant, P.N. Ainslie. Université Laval, Canada and University of British Columbia— Okanagan, Canada. E212 836.2 ‘’Elevated Cardiorespiratory Fitness Is Associated With Blunted Cerebral Pressure-Flow Relationships. P. Brassard, M. Paquette, O. Le Blanc, S. Malenfant, K. Rahimaly, S.J. Lucas, D.M. Bailey. Université Laval, Canada, Research Center of the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada, University of Birmingham, United Kingdom, University of South Wales, United Kingdom and University of British Columbia, Canada. E213 836.3 Akt Activation Improves Microregional Oxygen Supply/Consumption Balance After Cerebral IschemiaReperfusion. H. Weiss, O.Z. Chi, X. Liu. Rutgers Robert Wood Johnson Medical School. E214 836.4 Harmful Effects of Neonatal Epileptic Seizures on Cerebrovascular Functions: Does Sex Matter? J. Liu, A.L. Fedinec, C.W. Leffler, H. Parfenova. University of Tennessee HSC. E215 836.5 Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2, TRPV4 and Calcium-Activated Potassium Channels. N. Szarka, M.R. Pabbidi, K. Amrein, E. Czeiter, K. Pohoczky, Z. Helyes, Z. Ungvari, A. Buki, A. Koller, P.J. Toth. University of Pecs, Hungary, University of Mississippi, University of Oklahoma HSC and University of Physical Education, Hungary. E216 836.6 The Role of FGF2 and FGFBP in Cerebrovascular Response to Angiotensin II with Renal Ischemia-Reperfusion Injury in Mice. L. Zhao, X. Cao, S. Zhou, Q. Wang, L. Li, J. Zhao, J. Saavedra, C.S. Wilcox, A. Wellstein, E. Lai. Zhejiang University, People’s Republic of China, and Georgetown University. E217 836.7 Cerebrovascular Reactivity in Atrial Fibrillation. J.P. Fisher, I.D. Braz, S.J. Lucas, L. Edwards, J.J. van Lieshout, G.Y. Lip. University of Birmingham, United Kingdom and University of Amsterdam, Netherlands.
MONDAY PHYSIOLOGY E218 836.8 Endothelial Pannexin1 Can Regulate Cerebral Myogenic Tone Development and Severity of Ischemic Stroke. M.E. Good, H.M. Bacon, S.A. Eucker, S.M. Lang, J.T. Butcher, T.J. Johnson, J. Li, Z. Zuo, B.E. Isakson. University of Virginia and Duke University. E219 836.9 Integrative Physiology of Brain Perfusion During Extreme Chemoreflex Manoeuvers. J.K. Shoemaker, O.F. Barak, M.K. Badrov, L.N. Shoemaker, B.K. Matushewski, T. Mijacika, M. Lojpur, I. Drvis, Z. Dujic. University of Western Ontario, Canada, University of Novi Sad, Yugoslavia, University of Split, Croatia and University of Zagreb, Croatia. E220 836.10 Regional Patterns of Pulsatility Index and Wall Shear Stress Across Cerebral Circulation of Adolescents with High Insulin Resistance. K.J. Carter, J.M. Kellawan, G.L. Peltonen, A.T. Ward, A.L. Carrel, O. Wieben, B.B. Bendlin, W.G. Schrage. University of Wisconsin-Madison. E221 836.11 Altered Basal Cerebral Perfusion in Adolescents with Insulin Resistance. A.T. Ward, J.M. Kellawan, G.L. Peltonen, K.J. Carter, J.L. Rehm, J.M. Oh, A.L. Carrel, B.B. Bendlin, W.G. Schrage. University of Wisconsin-Madison. E222 836.12 High Fat Feeding Reduces Cerebral Artery Transient Receptor Potential Channel Vanilloid 4 (TRPV4) Expression in a Mineralocorticoid Receptor-Dependent Manner. A.M. Dorrance, J. Diaz-Otero, P.W. Pires, W.F. Jackson. Michigan State University and University of Nevada. E223 836.13 Steady State vs. Pulsatile Blood Pressure Component and Regional Cerebral Perfusion. J. Laosiripisan, A. Haley, H. Tanaka. The University of Texas at Austin. E224 836.14 Reactivity of Basilar and Circle of Willis Arteries Measured Simultaneously at 7 Tesla. L. Shoemaker, B. Al-Khazraji, J. Gati, T. Tzekeres, K. Shoemaker. University of Western Ontario, Canada. E225 836.15 Acid-Sensing Ion Channels: Mediator of Cerebrovascular Responses to CO2. F. Faraci, R. Taugher, R. Fan, J. Wemmie. University of Iowa. E226 836.16 Multiple Sclerosis Alters Dynamic Cerebral Autoregulation During Heat Stress. D.R. Allen, M.R. Huang, S. Purkayastha, R.M. Brothers, S.L. Davis. Southern Methodist University and University of Texas at Arlington. E227 836.17 Protecting Cerebral Microvascular Endothelial Cells in Diabetes Mellitus. K.R. Bidasee, F. Alomar, G.J. Rozanski, W. Mayhan, B. Padanilam, J. Singh. University of Nebraska Medical Center, University of Dammam, Saudi Arabia, University of South Dakota and University of Central Lancashire, United Kingdom. E228 836.18 Impaired Reactivity of Basilar and Circle of Willis Arteries in Osteoarthritis and Ischemic Heart Disease Patients. B.K. Al-Khazraji, M.B. Badrov, J.L. Vording, T.B. Birmingham, J. Shoemaker. The University of Western Ontario, Canada. E229 836.19 ATP-Sensitive Potassium Channels Contribute to Progressive Coronary Vasodilation in Response to Acute Isovolemic Hemodilution. A.M. Kiel, A.G. Goodwill, A.L. Barnard, J.T. Sturek, J.N. Noblet, D.J. Sassoon, J.D. Tune. Indiana University School of Medicine and Purdue University. E230 836.20 Initial Studies of Cardiovascular Monitoring Feasibility Using EndoGear 2, a Fully Implantable Telemetry System in Swine Model. A.G. Goodwill, F. Konecny, K. Pitsillides, M. Sosa, A.P. Barnard, A.M. Kiel, J.D. Tune. Indiana University School of Medicine, Transonic SciSense Inc, Canada, Transonic Endogear Inc and Transonic Systems Inc.
E231 836.21 A New Biotelemetry System to Monitor True Volumetric Blood Flow, Blood Pressure and Temperature in Small Animals: Preliminary Test Data in Rats. B. Arnall, V. Rotar, K. Pitsillides, M. Sosa, V. Garg, M.F. Callahan. University of Missouri, Tensive Controls Inc., Transonic EndoGear Inc. and Transonic Systems Inc. E232 836.22 Treatment of Long-Term Coronary Dysfunction in Diabetes with Mineralocorticoid Receptor Antagonism: Vasomotor Control and the MR-Dependent Vascular Transcriptome. S.M. Brown, A.I. Meuth, G.M. Meers, J.W. Davis, R.S. Rector, S.B. Bender. Harry S Truman Memorial Veterans Hospital, University of Missouri and University of Missouri School of Medicine. E233 836.23 The Effect of Alcohol Exposure in Utero on the Cerebral Circulation. S. Cananzi, W. Mayhan. LSUHSCShreveport and University of South Dakota. E234 836.24 No Evidence of Impaired Functional Sympatholysis in Young Obese Adults. K. Bunsawat, G. Grigoriadis, S. Wee, G. Griffith, M.D. Brown, S.A. Phillips, P.J. Fadel, P.S. Clifford, B. Fernhall, T. Baynard. The University of Illinois at Chicago and University of Texas at Arlington. E235 836.25 Brain Homogenates from Alzheimer’s Patients Impact Vascular Function. X. Zhang, J. Ma, I. Hajjar, R.L. Sutliff. Emory University/Atlanta VA Medical Center and Emory University School of Medicine. E236 836.26 High Dietary Sodium Reduces Low-FlowMediated Constriction in Salt-Resistant Adults. M. Ramick, S. Lennon-Edwards, W. Rose, W. Farquhar, D. Edwards. University of Delaware.
837. ENDOTHELIAL CELL BIOLOGY II Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E237 837.1 Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia. X. Dai, J. Zeng, J. Chen, L. Cai, Y. Tan. University of Louisville. E238 837.2 N-Cadherin Strengthens VE-Cadherin Adhesion Through Trio/Rac1 Signaling. K.J. Kruse, F. Huang, Y. Sun, S. Vogel, A. Malik, Y. Komarova. University of Illinois at Chicago. E239 837.3 Effects of Reactive Oxygen Species in Endothelial Cells Assessed by Observing Levels of JNK Activation. K. Latuska, S. Farwell, L. Lowe-Krentz. Lehigh University. E240 837.4 Racial Differences in Cell Adhesion Molecule Expression in HUVECs. A. Adeyemo, C. Ling, M.D. Cook, H. Grimm, M.D. Brown. University of Illinois- Chicago. E241 837.5 Racial Differences in CRP Receptor and Influence on eNOS Bioactivity and NO Production in Endothelial Cells. M. Aldokhayyil, C. Ling, M. Cook, H. Grimm, M.D. Brown. UIC. E242 837.6 MMP-2 Dysfunction in African Americans Endothelial Cells: Potential Biomarker of Hypertension Risk? M.D. Cook, M. Aldokhayyil, A. Adeyemo, B. Fernhall, M. Brown. University of Illinois at Chicago.
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PHYSIOLOGY MONDAY E243 837.7 Characterization of Exosomes Isolated from Cultured Vascular Endothelial and Smooth Muscle Cells. M. Boyer, A. Baggett, R. Scalia, S. Eguchi, V. Rizzo. Lewis Katz School of Medicine at Temple University. E244 837.8 Cholesterol Loading Rescues OxLDL-Induced Activation of Endothelial Rho/ROCK/Akt/p27kip1 Cascade. C. Zhang, I. Levitan. University of Illinois at Chicago. E245 837.9 HDAC1, NOS3, and Circadian Clock Gene Expression in the Endothelium. P. Pati, D. Pollock, J. Pollock. University of Alabama at Birmingham. E246 837.10 Extracellular Histones Induce Propagating Ca2+ Influx, Ca2+ Overload, and Endothelial Cell Death in Resistance-Sized Mouse Mesenteric Arteries. D.M. Collier, N.M. Villalba, A.M. Sackheim, K. Freeman, M.T. Nelson. University of Vermont. E247 837.11 An Automated, Label-Free Method for Quantifying Intercellular Gap Formation in Images of Cell Monolayers. C.M. Francis, K.A. Morrow, P. Renema, D.A. Teague, E. Agwaramgbo, G. Langham, T.C. Stevens, C.C. Williams, D.F. Alvarez, J.P. Audia, R.D. Balczon, T. Stevens. University of South Alabama, Alabama College of Osteopathic Medicine and Xavier University. E248 837.12 ADAM17 and Impaired Endothelial Insulin Signaling in Type 2 Diabetes. R.M. Restaino, J.A. CastorenaGonzalez, K.D. Marshall, J. Padilla, L.A. Martinez-Lemus. University of Missouri. E249 837.13 Pro-Atherogenic Disturbed Flow Increases Endothelial Stiffness via Enhanced CD36/Cav1-Mediated oxLDL Uptake. E. LeMaster, T. Shentu, R. Huang, C. Zhang, C. Adamos, I. Fancher, C. Ng, T. Christoforidis, P. Subbaiah, D. Eddington, M. Cho, Y. Fang, R. Minshall, I. Levitan. University of Illinois at Chicago and University of Chicago. E250 837.14 Heterogeneity of TRPV4 Expression and Function in Endothelial Cells of Different Vascular Beds. M. Maishan, D. Lamb, W.L. Lee, W.M. Kuebler. Keenan Research Centre, Canada, University of Toronto, Canada, Boehringer Ingelheim Pharma GmbH, Germany, Institute of Physiology and Charité—Universitätsmedizin, Germany. E251 837.15 Chloroquine Attenuates EndotheliumDependent Relaxation in Mouse Coronary Artery. Q. Zhang, J. Wang, A. Makino. University of Arizona. E252 837.16 Endothelial Specific Molecule 1 (Esm1) Inhibits Macrophage Infiltration in a Mouse Model of Goodpasture’s Syndrome. X. Zheng, L. Higdon, J. Maltzman, V. Bhalla. Stanford University. E253 837.17 Acetylcholine Activates Cystathionine γ-Lyase Production of H2S in Aortic Endothelial Cells. P. Mendiola, L.V. Gonzalez Bosc, L. Rios, J. Naik, N. Kanagy. University of New Mexico. E254 837.18 Testosterone Downregulates the Nrf2 System and Promotes Vascular Dysfunction in HFD-Fed Mice. R.M. Costa, R. Alves-Lopes, F. Mestriner, R. Tostes. Ribeirao Preto Medical School—University of Sao Paulo, Brazil. E255 837.19 Endothelial Function and Antioxidant Capacity Are Impaired in Adults Who Report Adverse Childhood Events. P. Rodriguez Miguelez, J. Looney, M. Blackburn, J. Thomas, J. Pollock, R. Harris. Augusta University, University of Alabama at Birmingham and University of Ulster, United Kingdom. E256 837.20 Tissue Inflammatory Responses in an Anesthetized Rat Hemorrhage Model Associated with Endothelial Dysfunction. M.A. Dubick, L.N. Torres, J.L. Barr, I.P. Torres Filho. US Army Institute of Surgical Research.
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E257 837.21 Mechanotransduction of the Endothelial Glycocalyx Mediates Nitric Oxide Production Through Activation of TRP Channels. X. Zhang, M. Dragovich, D. Chester, B. Fu. Lehigh University and The City College of New York.
838. CARDIAC RESPONSES TO EXERCISE Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E258 838.1 Development of a Left Ventricular Diastolic Stress Test. T.J. Samuel, R. Beaudry, M. Haykowsky, S. Sarma, P. Bhella, S. Park, M. Liew, M.D. Nelson. The University of Texas at Arlington, Texas Health Presbyterian Hospital, University of Texas Southwestern Medical Center and John Peter Smith Hospital. E259 838.2 Influence of Body Fat Distribution in Autonomic Dysfunction of Young Obese Women. W.R. Vicente, F.X. Fonseca, L.V. Silva, M.F. Hussid, S.D. Corso, K.D. Angelis, R.d. Vieira, H.F. Lopes, F.M. Consolim-Colombo, T. Tinucci, I.C. Trombetta. Universidade Nove de Julho (UNINOVE), Brazil and Heart Institute (InCor) University of São Paulo Medical School, Brazil. E260 838.3 Adolescent Children Born Preterm Have Altered Cardiac Regulation During and Immediately Following Maximal Exercise. M.D. Brix, K. Haraldsdottir, M. Palta, A. Beshish, L. Tetri, K. Goss, A. Watson, M. Eldridge. University of Wisconsin-Madison. E261 838.4 Blunted Stroke Volume Response to Exercise in Adolescent Children Born Premature. A Cardiac MRI Study. K. Haraldsdottir, L. Tetri, A. Beshish, K. Goss, A. Watson, M. Palta, M. Eldridge. University of Wisconsin-Madison. E262 838.5 Potential Sympathetic Activation in Response to a Training Macrocycle Is Associated with Sport Injuries Incidence in Competitive Sprint Swimmers. S.A. OliveiraJunior, D.S. Lima-Borges, L.M. Vanderlei, F.S. Barbosa, M.P. Okoshi, K. Okoshi, P.F. Martinez. Federal University of Mato Grosso do Sul, Brazil and Sao Paulo State University, Brazil. E263 838.6 Physical Training Improves Cardiac Structure and Function, Antioxidant Capacity, and Exercise Tolerance in Spontaneously Hypertensive Rats. M.P. Okoshi, L. Pagan, R. Damatto, M. Cezar, D. Campos, A. Lima, F. Damatto, M. Gomes, T. Caldonazo, K. Okoshi. Botucatu Medical School, Sao Paulo State University and UNESP, Brazil. E264 838.7 Hemodynamics Dys-Regulation During the Muscle Metaboreflex in Patients with Coronary Artery Disease. A. Crisafulli, S. Roberto, G. Sainas, R. Milia, G. Palazzolo, S. Vanni, V. Pinna, A. Doneddu, F. Tocco, S. Magnani. University of Cagliari, Cagliari, Italy. E265 838.8 Voluntary Exercise Enhances Cardiac Growth in Response to Chronic β-Adrenergic Receptor Stimulation. M.K. O’Connor Lenth, S. Soo, S. Luckey, N. McLaughlin. Seattle University. E266 838.9 Tsg101 Regulates Rab11FIP3-Mediated Endosomal Recycling of IGF-1R in Physiological Cardiac Hypertrophy. K. Essandoh, X. Wang, M. Jiang, X. Mu, J. Peng, Y. Li, S. Deng, E. Salem, J. Rubinstein, G. Fan. University of Cincinnati College of Medicine.
MONDAY PHYSIOLOGY
839. EXERCISE TRAINING RESPONSES Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E267 839.1 Effect of 4 Weeks of High-Intensity Interval Training on Exercise Performance and Markers of Inflammation and Oxidative Stress. K.A. Zwetsloot, D.C. Nieman, A. Knab, C.S. John, D.D. Lomiwes, R.D. Hurst, N.D. Gillitt, M.A. Lila. Appalachian State University, Appalachian State University, North Carolina Research Campus, Queens University of Charlotte, The New Zealand Institute for Plant and Food Research Ltd., New Zealand, Dole Nutrition Research Laboratory, North Carolina Research Campus, Plants for Human Health Institute, North Carolina State University and North Carolina Research Campus. E268 839.2 Physiological Cardiac Hypertrophy of Exercise Training Is Absent in Mice Deficient in Adiponectin. J.M. MullerDelp, K.M. Dieseldorf-Jones, J.M. Pinto, K. Burodonovich, K. Hotta, M. Delp, B. Behnke. Florida State University, LECOM and Kansas State University. E269 839.3 Skeletal Muscle Adaptations to Exercise in a Pre-Clinical Model of Myotonic Dystrophy Type 1. A. Manta, D.W. Stouth, I.A. Rebalka, J.M. Kalmar,T.J. Hawke,V. Ljubicic. McMaster University, Canada and Laurier University, Canada. E270 839.4 Effects of Cycling Exercise on Mitochondrial Function and Efficacy of Peripheral Blood Mononuclear Cells Under Hypoxic Condition in Sedentary Men. S. Chang, J. Wang. Graduate Institute of Rehabilitation Science, Medical College, Chang Gung University, Taiwan, Heart Failure Center, Department of Physical Medicine and Rehabilitation and Chang Gung Memorial Hospital, Taiwan. E271 839.5 Exercise Increases Brain-Derived Neurotrophic Factor in Serum Exosomes. W. Saengsawang, S. Kongoun, M. Chanda. Faculty of Science, Mahidol University, Thailand, Faculty of Physical Therapy, Mahidol University, Thailand, Faculty of Veterinary Medicine and Kasetsart University, Thailand. E272 839.6 Effect of Exercise Training on Mobilization and Functionality of Endothelial Progenitor Cells Undergoing Hypoxic Stress. J. Wang. Chang Gung University, Taiwan. E273 839.7 Physiological, Immunological and Biochemical Changes in Athlets During Adventure Race. R.P. Silva, C.F. Silva, C.S. Bortolini, L.E. Maggi, M.J. Bortolini, A. Vilaça, N. Penha-Silva. Federal University of Acre, Brazil and Federal University of Uberlândia, Brazil. E274 839.8 Influence of Exercise and Maternal Lipids During Pregnancy on Neonatal Size. L.E. May, C.M. Moyer, E. Newton, D. Strickland, C. Isler, K. Haven, J. DeVente, L. Chasan-Taber, G. Kelley, X. Fang. East Carolina University, Bridgewater College, University of Mass-Amherst and West Virginia University. E275 839.9 Combined Exercise Training (Aerobic Plus Resistance) Promotes Additional Cardiovascular Benefits in Relation to Aerobic or Resistance Alone in Experimental Model of Menopause. I.C. Sanches, G.M. Costa, S.C. Freitas, N. Bernardes, M. Doro, M. Irigoyen, K. De Angelis. São Judas Tadeu University, Brazil, Universidade Nove de Julho, Brazil and University of São Paulo, Brazil.
E276 839.10 disruption of Adenylyl Cyclase Type 5 Eliminates Gender Differences in Exercise Capacity. N.D. Rynecki, J. Guers, J. Zhang, D. Vatner, S. Vatner. Rutgers University- New Jersey Medical School. E277 839.11 Multiple Sclerosis Patients Do Not Show Changes in Wave Intensity Analysis Following Home-Based Exercise. G. Griffith, S. Wee, R. Klaren, R. Motl, T. Baynard, B. Fernhall. University of Illinois at Chicago, University of Illinois and UAB/Lakeshore Research Collaborative. E278 839.12 Effects of Eccentric and Concentric Cycling Exercise Regimens on Hemodynamic and Hemorheologic Properties in Sedentary Males. C. Huang, J. Wang. Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Medical Collage, Chang Gung University, Tao-Yuan and Taiwan, Taiwan. E279 839.13 Relationships Between Functional Capacity and Hemodynamic Characteristics in Patients with Peripheral Arterial Disease. T. Fu, Y. Lin, S. NG, J. Wang, C. Yeh. Chang Gung Memorial Hospital, Taiwan and Chang Gung University, Taiwan. E280 839.14 Heart Rate Recovery Improvement Is Greater After Evening Than Morning Aerobic Training in Treated Hypertensive Men. L.C. Brito, T. Peçanha, R. Fecchio, R. Rezende, P. Sousa, G. Silva, A. Abreu, D.C. Mion Junior, J. Halliwill, C. Forjaz. University of Sao Paulo, Brazil and University of Oregon. E281 839.15 Activated mTORC1 by Eccentric Contractions Contributes to Induce LAT1 mRNA Expression in Mouse Skeletal Muscle. H. Takada, Y. Tando, A. Nunomiya, S. Osana, H. Tsunekawa, T. Murakami, R. Nagatomi. Tohoku University Graduate School of Medicine, Japan, Tohoku University Graduate School of Biomedical Engineering, Japan, Department of Nutrition and Shigakkan University, Japan. E282 839.16 P53 Regulation of Cellular Homeostasis in Skeletal Muscle with Training: An Evaluation of Two Mouse Models. K. Beyfuss, A.T. Erlich, D. Hood. York University, Canada. E283 839.17 Regulation of Autophagy During Chronic Contractile Activity-Induced Muscle Adaptations. Y. Kim, M. Triolo, D.A. Hood. York University, Canada. E284 839.18 Parkin-Mediated Mitophagy in Skeletal Muscle with Endurance Training. C. Chen, D. Hood. York University, Canada. E285 839.19 One-Step Real Time RT-PCR for the Detection of Exercise-Inducing Circulating Micrornas in Sedentary Males. K.J. Chen, C. Huang, K. Lin, J. Wang. Chang Gung University, Taiwan. E286 839.20 AICAR Treatment Does Not Prevent Increases in Exercise Capacity or Muscle Heat Shock Protein 25 with Treadmill Training in Mice. K. Godwin, K. Huey. Drake University. E287 839.21 Dynamic Proteome Profiling of the Human Muscle Response to Resistance Exercise Training. J.G. Burniston, D.M. Camera, M.A. Pogson, J.A. Hawley. Liverpool John Moores University, United Kingdom and Australian Catholic University, Australia. E288 839.22 Effects of Eccentric and Concentric Cycling Exercise Regimens on Hypoxia-Mediated Mitochondrial Bioenergetics of Platelets in Sedentary Males. Y. Wu, J. Wang. Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Medical College and Chang Gung University, Taiwan.
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PHYSIOLOGY MONDAY E289 839.23 Repeated Sprint Training in Hypoxia Improves Exercise Tolerance in Recreationally Trained Men: A Randomized Single-Blind Study. R. Wang, D.H. Fukuda, M.B. La Monica, T.M. Starling, J.R. Stout, J.R. Hoffman. University of Central Florida. E290 839.24 Exercise Combined With Low-Level GABAA Receptor Inhibition Up-Regulates the Expression of Neurotrophins in the Motor Cortex. K. Takahashi, H. Maejima, G. Ikuta, T. Asaka, H. Mani. Hokkaido University, Japan and Tonan Hospital, Japan. E291 839.25 Change in Acute Response of Aged Women to Resistance Exercise Following a Long-Duration Stretching Intervention. J.E. Hibbert, T.E. Jones, Z.J. Domire. Ball State University and East Carolina University. E292 839.26 Acute and Chronic Varied Exercise Intensity Effects on Total Antioxidant Capacity and Protein Carbonylation. E.C. Wuorinen, R. Page, S.H. Wuorinen. Northern Michigan University and Norwich University.
840. VASCULAR RESPONSES TO EXERCISE AND ENVIRONMENTAL STRESS Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E293 840.1 Enhanced Microvascular Function in the Cutaneous Circulation with Platelet Inhibition Is Not Related to Alterations in Blood Viscoelastic Properties. T.B. Garner, J. Dahmus, K. Manning, L. Alexander. The Pennsylvania State University and Thomas Jefferson School of Medicine. E294 840.2 Effects of Glycyrrhetic Acid and Other Chemical Components of Shakuyakukanzoto on Cutaneous Microcirculation in Humans. G.A. Dillon, S.M. Ranadive, M.J. Joyner, A.R. Eugene, K.M. Tasaki, D.M. Noble. Mayo Clinic and University of Oxford, United Kingdom. E295 840.3 Combined Norepinephrine and ATP Antagonism Attenuates the Vasoconstriction Response in Young Adult Skin. A.C. Krajek, K.A. Smaller, J.A. Lang. Des Moines University and Drake University. E296 840.4 Acute Lysyl Oxidase Inhibition Augments Cutaneous Vasoconstriction in Normotensive, but Not Hypertensive, Men and Women. D.H. Craighead, L. Santhanam, L.M. Alexander. Penn State University and Johns Hopkins University School of Medicine. E297 840.5 The Effect of Protease-Activated Receptor 2 on Cutaneous Vasodilation and Sweating in Young Males During Exercise in the Heat. L. Halili, M. Danquah, N. Fujii, B. McNeely, G. Kenny. University of Ottawa, Canada, Carleton University, Canada and University of Tsukuba, Japan. E298 840.6 Alternate Quantification Approaches for Cold Induced Vasodilation in Human Glabrous Skin. T.E. Wilson, D. Gerow, P. Clegg, K. Metzler-Wilson. Marian University College of Osteopathic Medicine. E299 840.7 Activation of Protease-Activated Receptor 2 Directly Mediates Cutaneous Vasodilatation but Not Sweating in Humans in Vivo: Roles of Nitric Oxide Synthase and Cyclooxygenase. B.D. McNeely, N. Fujii, S.Y. Zhang, M.O. Daquan, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan.
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E300 840.8 The Influence of Heat Shock Protein 90 on Sweating and Cutaneous Vasodilation in Young Males During Exercise in the Heat. B.D. McNeely, S.Y. Zhang, N. Fujii, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan. E301 840.9 The Effect of Exogenous Adenosine Triphosphate on Blood Flow Kinetics During Dynamic Forearm Exercise. J.R. Shepherd, M.J. Joyner, G.A. Dillon, F.A. Dinenno, T.B. Curry, S.M. Ranadive. Mayo Clinic and Colorado State University. E302 840.10 Individual and Combined Effects of Phosphodiesterase-5 and Nitric Oxide Synthase Inhibition to Vasodilation During Moderate Exercise. J.M. Kellawan, J.K. Limberg, Z.M. Scruggs, W.T. Nicholson, W.G. Schrage, M.J. Joyner, T.B. Curry. University of Wisconsin—Madison and Mayo Clinic College of Medicine. E303 840.11 Effect of Nitric Oxide Synthase Inhibition on Plasma ATP During Hypoxia and Exercise Induced Vasodilation in Humans. S.M. Ranadive, G.A. Dillon, J.A. Shepherd, S.C. Wolhart, F.A. Dinenno, T.B. Curry, M.J. Joyner. Mayo Clinic and Colorado State University. E304 840.12 Influence of Muscle Fiber Recruitment on Local Vasodilation During Work-Matched Exercise in Humans: Role for KIR Channel Activation. J.D. Terwoord, C.M. Hearon Jr., M.L. Racine, G.J. Luckasen, F.A. Dinenno. Colorado State University, Medical Center of the Rockies Foundation and University of Colorado Health. E305 840.13 Contribution of Adenosine to Skeletal Muscle Contraction-Induced Vasodilation in Humans Is Not Increased with Age. M.L. Racine, C.M. Hearon; Jr., J.C. Richards, G.J. Luckasen, M.J. Joyner, F.A. Dinenno. Colorado State University, Medical Center of the Rockies Foundation, University of Colorado Health and Mayo Clinic. E306 840.14 Skeletal Muscle Vascular and Metabolic Control and Microgravity Exposure: Potential Disruptive Role of Free Hemoglobin in Convective and Diffusive O2 Transport. S.K. Ferguson, K.R. Stenmark, D.C. Irwin. University of Colorado and Denver. E307 840.15 Acute Folic Acid Ingestion Improves Skeletal Muscle Blood Flow During Graded Handgrip and Plantar Flexion Exercise in Aged Humans. S.A. Romero, D. Gagnon, A.N. Adams, M.N. Cramer, M.F. Jaffery, K. Kouda, G. Moralez, C.G. Crandall. University of Texas Southwestern Medical Center, Université de Montréal, Canada, Texas Health Presbyterian Hospital Dallas and Wakayama Medical University, Japan. E308 840.16 The Effect of a High-Fat Meal on Vascular Stiffness in Young Healthy Males. W. Tucker, J. Patik, B. Curtis, S. Park, M. Nelson, R. Brothers. University of Texas at Arlington. E309 840.17 Measurement of Skeletal Muscle Blood Flow with Near-Infrared Diffuse Correlation Spectroscopy. R. Rosenberry, C. Ganesh, F. Tian, M.D. Nelson. University of Texas at Arlington. E310 840.18 The Effect of an Antioxidant Cocktail on Indices of Cerebral and Peripheral Vascular Function in Healthy College-Age Men. B.M. Curtis, J.C. Patik, J.R. Vranish, J. Kaur, B.E. Young, P.J. Fadel, R. Brothers. The University of Texas at Arlington. E311 840.19 The Effect of an Antioxidant Cocktail on Endothelial Function in Healthy Caucasian and African American Men. J.C. Patik, J.R. Vranish, B.M. Curtis, J. Kaur, B.E. Young, P.J. Fadel, R. Brothers. The University of Texas at Arlington.
MONDAY PHYSIOLOGY E312 840.20 Leg Endothelial Dysfunction Induced by Reduced Daily Physical Activity Is Mediated by a Reduction in Shear Stress. A.L. Teixeira, J. Padilla, L.C. Vianna. University of Brasília, Brazil and University of Missouri. E313 840.21 Carotid Vascular Blood Flow in Individuals with Down Syndrome Following Low Body Negative Pressure Challenge. S. Wee, A.J. Rosenberg, B. Kanokwan, G. Griffith, T. Baynard, B. Fernhall. University of Illinois at Chicago. E314 840.22 Effects of Hybrid Exercise Program on Subclinical Vascular Markers in Young Patients with Permanent Lower-Limb Disability. D. Suksom, K. Srihirun, A. Siripatt, S. Siripanya, H. Tanaka. Faculty of Sports Science, Chulalongkorn University, Thailand, Faculty of Physical Education, Srinakharinwirot University, Thailand and The University of Texas at Austin. E315 840.23 Acute Effects of Walking on Human Internal Carotid Blood Flow. E.R. Greene, K. Shrestha, A. Garcia. NMHU. E316 840.24 Sympathetic Nervous System Activation Reduces Contraction-Induced Rapid Vasodilation in the Leg of Humans Independent of Age. W.E. Hughes, N.T. Kruse, D.P. Casey. University of Iowa. E317 840.25 Basal Endothelial Cell Autophagy Is Elevated in Trained vs. Sedentary Mice. J. Cho, J. Kim, J. Allsop, T. Bean, T. Bonn, G. Hestwood, K. Yang, M. Drummond, P. Babu, J. Symons. University of Utah. E318 840.26 Nasal Administration of Diesel Exhaust Particles Does Not Evoke Dysfunction or Initiate Autophagy in Murine Femoral Arteries. J. Cho, J. Kim, J.B. Lewis, P.R. Reynolds, B. Bikman, J. Symons. University of Utah and Brigham Young University. E319 840.27 Combined Effect of Heating and Electrical Stimulation on Endothelial Vasodilator Function. E. Iwamoto, S. Oiwa, J. Takami, R. Nagaoka, S. Ito, T. Neki, M. Katayose. Sapporo Medical University, Japan and University of Iowa. E320 840.28 Aerobic Training Restores Endothelial Function in Intrauterine Growth Restricted Rats: Possible Involvement of eNOSThr495 Phosphorylation. V. Oliveira, L. Victorino, S. Silva Junior, T. Fernandes, E. Akamine, M.C. de Carvalho, E.M. de Oliveira, L.C. Michelini, M. Franco. Federal University of São Paulo, Brazil and University of São Paulo, Brazil. E321 840.29 Sex Differences in Central and Peripheral Cardiovascular Response with Trigeminal Nerve Stimulation During Dynamic Exercise. E. Prodel, T.C. Barbosa, I. Galdino, G. Alexandria, A.C. Nobrega, L.C. Vianna. Fluminense Federal University, Brazil and University of Brasilia, Brazil. E322 840.30 Effects of Aerobic Capacity on Arterial Stiffness in Individuals with Multiple Sclerosis. G. Grigoriadis, A.J. Rosenberg, S. Wee, E.C. Schroeder, T.I. Hilgenkamp, G. Griffith, T. Baynard. University of Illinois at Chicago, Erasmus MC University Medical Center Rotterdam and the Netherlands, Netherlands.
841. HYPOXIA AND HIGH ALTITUDES Poster (Sponsored by: APS Hypoxia Group) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E323 841.1 Impact of Sleep Disordered Breathing on Carotid Body Size. H.G. Petersen-Jones, B.T. Welch, A.R. Eugene, W. Brinjikji, D.F. Kallmes, T.B. Curry, M.J. Joyner, J.K. Limberg. Mayo Clinic. E324 841.2 Hypoxic Preconditioning Improves Respiratory Muscle Function During Hypoxia by Regulating Mitochondria in COPD Mice. L. Zuo, C. Chuang, T. Zhou. Ohio State University. E325 841.3 Catecholamine Secretion from the Adrenal Medulla Is Blunted in High-Altitude Deer Mice (Peromyscus maniculatus). A.L. Scott, N.A. Pranckevicius, P. Patal, C.A. Nurse, G.R. Scott. McMaster University, Canada. E326 841.4 Ventilatory Acclimatization to Hypoxia in Deer Mice Native to High Altitudes. C.M. Ivy, G.R. Scott. McMaster University, Canada. E327 841.5 Norepinephrine (NE) and Intermittent Hypoxia (IH) Impact Short Term Synaptic Plasticity in the Hippocampus. J.E. Barnard, M.A. Khuu, A.J. Garcia III. The University of Chicago. E328 841.6 Perinatal Supplemental Oxygen Alters the Ventilatory and Pulmonary Vascular Responses to Hypoxia in Adult Rats. M. Hoover, T.J. Greiner, D. Rotella, S. Vellookunnel, S. Chandrasekar, M. Bates. University of Iowa. E329 841.7 Adrenal Chromaffin Cell Function in HighAltitude Deer Mice (Peromyscus maniculatus). N.A. Pranckevicius, A.L. Scott, C.A. Nurse, G.R. Scott. McMaster University, Canada. E330 841.8 Ventilatory and Carotid Body Chemosensory Responses in Rats Exposed to Short-Term Sustained Hypoxia. K.C. Flor, E.F. Silva, M.F. Menezes, G.R. Pedrino, E. Colombari, D.B. Zoccal. School of Dentistry of Araraquara, Sao Paulo State University, Brazil and Federal University of Goias, Brazil. E331 841.9 Chemoreflexes: A Major Component of Adaptation to High Altitude/Hypoxic Environment. J. Richalet, N. Voituron, E. Hermand, F. Jeton, F.J. Lhuissier. Université Paris 13, Sorbonne Paris Cité and EA2363 “Hypoxie et poumons”, France. E332 841.10 Genetic Risk Factors of Chronic Mountain Sickness. J. Richalet, S. Gazal, J.R. Espinoza, F. Austerlitz, J. Macarlupu, F. Leon-Velarde, D. Marchant, L. Gouya. Université Paris 13, Sorbonne Paris Cité, EA2363 “Hypoxie et poumons”, France, INSERM U1149, France, Universidad Cayetano Heredia, Peru and Musée de l’Homme, France. E333 841.11 Cognitive Assessment Following Sleep Apnea Treatments at High Altitude. M.A. Djokic, E.C. Heinrich, D. Gilbertson, P. DeYoung, N. Bosompra, J. Orr, F.L. Powell, A. Malhotra, T.S. Simonson. University of California—San Diego. E334 841.12 Effect of Normobaric Hypoxia Simulating 3,500 m on SpO2 and Workload in Women During Exercise at 65% VO2peak. K. Kambis, M. Yasukawa, A. Degarmo, L. Quiroga, V. Barbour, S. Muza, R. Looft-Wilson. College of William & Mary, Chuo University, Japan and U.S. Army Research Institute of Environmental Medicine.
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PHYSIOLOGY MONDAY E335 841.13 Intermittent Hypoxic Challenge in Conscious Rats Elevates Heart Rate But Does Not Increase Lumbar Sympathetic Nerve Activity. M. Muntzel, J. Loera, G. Coffee, P. Getsy, S.J. Lewis. Lehman College (CUNY), University Rochester and Case Western Reserve University. E336 841.14 Carotid Chemoreceptor Control of Muscle Sympathetic Nerve Activity in Hypobaric Hypoxia. J.P. Fisher, D. Flück, M.P. Hilty, C. Lundby. University of Birmingham, United Kingdom, University of Zürich, Switzerland and University Hospital of Zürich, Switzerland. E337 841.15 Chronic Intermittent Hypoxia Decreases the Levels of Corticotropin-Releasing Hormone Receptor 2 in the Nucleus of the Solitary Tract in Rats. L. Wang, S. Mifflin. University of North Texas Health Science Center. E338 841.16 The Brain, Not the Kidney, Is the Source of Erythropoietin in Response to Hypoxic Hypoxia. M.A. Allwood, N. Romanova, K.R. Brunt, J.A. Simpson. University of Guelph, Canada and Dalhousie Medicine New Brunswick, Canada. E339 841.17 Prolonged High Altitude Exposure Exacerbates Fat-Free Mass and Fat Mass Loss During Negative Energy Balance Regardless of Dietary Protein Intake. C.E. Berryman, J. Karl, R.E. Cole, R.W. Kenefick, L.M. Margolis, J.W. Carbone, A.A. Ferrando, H.R. Lieberman, A.J. Young, S.M. Pasiakos. Oak Ridge Institute for Science and Education, US Army Research Institute of Environmental Medicine, Eastern Michigan University and University of Arkansas for Medical Sciences. E340 841.18 Higher-Protein Intake During Sustained Negative Energy Balance Attenuates Elevations in Resting Metabolic Rate at High Altitude (4300 m). A. Derosier, C.E. Berryman, J. Karl, M. Wilson, A.J. Young, S.M. Pasiakos. US Army Research Institute of Environmental Medicine and Oak Ridge Institute for Science and Education. E341 841.19 Vessel Reactivity and Blood Flow in Rats Exposed to Neonatal Supplemental Oxygen. S. Vellookunnel, S. Chandrasekar, M. Sturgeon, A. Murphy, M. Hoover, M. Bates. University of Iowa.
E344 842.3 Elevated Aortic Stiffness Is Associated with Reduced Cerebrovascular Reactivity but Not Global Cerebral Blood Flow Among Middle-Aged/Older Humans. L.E. DuBose, L.L. Boles Ponto, E. Harlynn, D.J. Moser, G.L. Pierce. University of Iowa. E345 842.4 The Effects of Acute Aerobic Exercise on Cerebral Blood Flow and Cognition in Persons with Multiple Sclerosis. A.J. Rosenberg, S. Wee, E.C. Shroeder, G. Grigoriadis, B.M. Sandroff, K. Bunsawat, T.I. Hilgenkamp, G.J. Griffith, R. Motl, T. Baynard. University of Illinois at Chicago, Kessler Foundation, Erasmus MC University Medical Center Rotterdam, Netherlands and University of Alabama at Birmingham. E346 842.5 Pilot Study: Effects of Short-Term Summer School Program on Plasma Cognitive Marker and NonLipid Cardiovascular Risk Factors in Female Adolescents. M. Choi, K. Park. Oakland University and Texas A&M International University. E347 842.6 Knockout of Matrix Metalloproteinase-9 Rescues the Development of Cognitive Impairments in Hypertensive Dahl Salt Sensitive Rats. F. Fan, S. Wang, P.N. Mims, K.J. Maeda, L. Li, A.M. Geurts, R.J. Roman. University of Mississippi Medical Center and Medical College of Wisconsin. E348 842.7 Exercise Ameliorated Cognitive Dysfunction Through Mitochondrial Remodeling in Alcohol Administrated C57BL/6 Mice. K.E. Kelly, A.K. George, J. Behera, N. Tyagi. University of Louisville.
842. VASCULAR MECHANISMS OF COGNITION
E349 843.1 The Effects of Sildenafil, Phosphodiesterase 5 Inhibitor, on the Expression of α and β Myosin Heavy Chains in Hypoxia Induced Right Ventricular Hypertrophy in Mice. S.Y. Khatib, M.M. AlJanabi. Jordan University of Science and Technology, Jordan. E350 843.2 Simvastatin Inhibits Myocardial Apoptosis Through Targeting miR-15a-5p Undergoing Cardiac Surgery. Z. Ou, L. Zhou, X. Liu, Y. Li, Xu, X. Zhang, Y. Xu, Z. Wang, J. Ou. The First Affiliated Hospital of Sun Yat-sen University, China and People’s Republic of. E351 843.3 Developing a Link Between Cardiac Function and Maternal Engineered Nanomaterial Exposure in Growing Progeny. Q.A. Hathaway, C. Nichols, D. Shepherd, P. Stapleton, S. McLaughlin, J. Stricker, S. Rellick, M. Pinti, A. Abukabda, C. McBride, J. Yi, S. Stine, T. Nurkiewicz, J. Hollander. West Virginia University. E352 843.4 Myocardial Adaptations to Chronic Intermittent Pressure Overload Protect the Heart Against Stretch-Induced Stunning and Cardiac Troponin I Release. B.R. Weil, R.F. Young, J.M. Canty; Jr. University at Buffalo. E353 843.5 Environmental Enrichment Alters the Impact of Social Stress on the Cardiovascular System. M. Normann, N. McNeal, W. Colburn, A. Dagner, E. Ihm, A. Toghraee, M. Woodbury, A.J. Grippo. Northern Illinois University.
Poster (Sponsored by: APS Cardiovascular Section) (Cosponsored by: APS Environmental and Exercise Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E342 842.1 Aortic Hemodynamics and Cognition in Women with a History of Hypertensive Pregnancy. K.B. Miller, J.A. Fields, R.E. Harvey, B.D. Lahr, M.J. Joyner, V.M. Miller, J.N. Barnes. University of Wisconsin-Madison and Mayo Clinic. E343 842.2 Cerebral and Peripheral Circulation and Progression of Alzheimer’s Disease. A. Pedrinolla, M. Venturelli, C. Fonte, I. Boscolo Galazzo, L. Crispoltoni, M. Benetti, A. Stabile, A. Pistilli, M. Rende, F.B. Pizzini, N. Smania, F. Schena. University of Verona, Italy and University of Perugia, Italy.
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843. CARDIAC FUNCTION AND DYNAMICS Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm
MONDAY PHYSIOLOGY E354 843.6 Activation of the GPR30 Receptor Inhibits Aldosterone-Induced Cardiac Hypertrophy. A. Orlowski, R.A. Di Mattía, E.A. Aiello. Centro de Investigaciones Cardiovasculares, Argentina. E355 843.7 Exposure to PM2.5 in Utero Contributes to Early Adult Cardiac Dysfunction. V. Tanwar, J. Adelstein, J. Grimmer, D. Youtz, L. Wold. Ohio State University. E356 843.8 Proteomic Analysis of Titin Phosphorylation and Sarcomere Stiffness in the Human Heart. M. Heroux. Loyola University Chicago. E357 843.9 Assessing Cardiac Function During Simulated Activities of Daily Living: A Magnetic Resonance Imaging Study. R.I. Beaudry, T.J. Samuel, W. Tucker, V.G. Zaha, M. Singhavi, M.J. Haykowsky, M.D. Nelson. University of Texas at Arlington and University of Texas Southwestern Medical Center. E358 843.10 The Effect of Methylglyoxal (MGO) on the Cardiac Myofilament. M. Papadaki, R. Holewinski, M. Stachowski, J. Kirk. Loyola University Chicago and Cedars Sinai Medical Center. E359 843.11 Cholesterol Depletion Increased Cardiomyocyte Contractility Associated with Phosphorylation of Cytosolic AKT. M.Z. Haque, V.J. McIntosh, R.M. Mohammad, A.A. Samra, R.D. Lasley. Hamad Medical Corporation, Qatar, Henry Ford Hospital and Wayne State University. E360 843.12 Amelioration of Sodium Fluoride-Induced Hypertension, Cardio-Renal Oxidative Stress and Genotoxicity by Azadirachta indica Through Antioxidant and Extracellular Signal-Regulated Kinase (ERK) 1/2 Signalling. O. Adejumobi, T. Omobowale, A. Oyagbemi, O. Ayenuro, O. Ola-Davies, A. Adedapo, M. Yakubu. University of Ibadan, Nigeria and Texas Southern University. E361 843.13 Sex Differences in Global and Regional Cardiac Function in Response to Acute Hypoxia. L. Vildberg, G. Barton, A. McMillan, N. Aggarwal, K. Goss, M. Eldridge. UW-Madison. E362 843.14 Cardiac Hypertrophy and Ventricular Contractility in Rats Exposed to Neonatal Supplemental Oxygen and High Fat Diet. S. Chandrasekar, S. Vellookunnel, M. Hoover, M. Sturgeon, A. Murphy, M. Bates. University of Iowa. E363 843.15 Time-Released Caffeine Ingestion in Habitual Users May Extend Parasympathetic Influence as Determined by Heart Rate Variability. M.B. La Monica, D.H. Fukuda, A.M. Gonzalez, R. Wang, A.J. Wells, J.R. Stout, J.R. Hoffman. University of Central Florida and Hofstra University. E364 843.16 Acute Changes in Left Ventricular Mechanics During Voluntary Apnea. S.L. Sutterfield, J.R. Smith, D.R. Baumfalk, K.D. Didier, C.J. Ade. Kansas State University. E365 843.17 Zinc Deficiency Worsens and Zinc Supplement Prevents the Development of Diabetic Cardiomyopathy, Respectively, in the db/db Mice: A Key Role of Nrf2. B. Wang, S. Wang, J. Tong, Y. Wang, L. Cai. The Second Hospital of Jilin University, People’s Republic of China, The University of Louisville, The First Hospital of Jilin University, People’s Republic of China. E366 843.18 Left Ventricular Remodeling and Cardiac Dysfunction in Long-Term Burn Survivors. A. Nasirian, M. Nelson, K. Kouda, S. Romero, A. Adams, M. Jaffery, M. Cramer, G. Moralez, K. Kowalske, H. Phelan, S. Wolf, N. Merz, Crandall. University of Texas at Arlington, Institute for Exercise and Environmental Medicine, The University of Texas Southwestern Medical Center and Cedars-Sinai Heart Institute.
E367 843.19 Cardiovascular System Explained on the Bases of Sports, Taught by Undergraduate Students Majoring in Biomedical Sciences or Biology. H. Lopez, M. HernandezVelez. Texas A&M University in Kingsville. E368 843.20 The Dipeptidyl Peptidase IV Inhibitor Saxagliptin Prevents Angiotensin II-Induced Cardiac Diastolic Dysfunction: Potential Involvement of Cardiac Lymphocytes? S.M. Brown, C.E. Smith, M. Khan, A.I. Meuth, J.R. Sowers, B. Chandrasekar, V.G. DeMarco, R. Nistala, S.B. Bender. Harry S Truman Memorial Veterans Hospital, University of Missouri and University of Missouri School of Medicine. E369 843.21 B-Raf Is Required for IsoproterenolInduced Hypertrophy. K. Rees, M. Takahashi, P.J. Stork, K.L. Thornburg, N.N. Chattergoon. Oregon Health and Science University.
844. SYMPATHETIC REGULATION IN HEART FAILURE Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E370 844.1 Cervicothoracic Transcutaneous Electrical Nerve Stimulation Attenuates Cardiac Sympathetic Overdrive in Heart Failure: A 123lMIBG Myocardial Scintigraphy, Randomized Double-Blind Crossover Trial. I.A. Fernandes, M.O. Campos, S.M. Miranda, M.C. Ribeiro, A.S. Braghiroll, C.T. Mesquita, A.C. Nóbrega. Fluminense Federal University, Brazil and IEN, Brazil. E371 844.2 Pharmacological Cardiac Sympathetic Afferent Denervation in Pacing-Induced Heart Failure. D. Senador, J. Kaur, J.A. Sala-Mercado, A.C. Krishnan, A. Alvarez, H.W. Hanna, A.T. Lovelace, M.M. Rasaiah, Y.H. Altamimi, D.S. O’Leary. Wayne State University School of Medicine. E372 844.3 Brain Tumor Necrosis Factor-α Converting Enzyme Contributes to Sympathetic Activation in Heart Failure Rats. S. Wei, Y. Yu, R.M. Weiss, R.B. Felder. University of Iowa Carver College of Medicine and VA Medical Center. E373 844.4 Specific Afferent Renal Denervation Improves Reduced nNOS in the Paraventricular Nucleus in Rats with Heart Failure. H. Zheng, X. Liu, M.M. Knuepfer, K.P. Patel. University of Nebraska Medical Center and St. Louis University School of Medicine. E374 844.5 Altered Arterial Baroreflex—Muscle Metaboreflex Interaction in Heart Failure. J. Kaur, D. Senador, A.C. Krishnan, A. Alvarez, H.W. Hanna, D.S. O’Leary. University of Texas at Arlington and Wayne State University School of Medicine. E375 844.6 Angiotensin II Type 1a Receptor Knockdown in Subfornical Organ Attenuates Central Expression of Inflammatory Mediators and Ameliorates Peripheral Manifestations of Heart Failure in Rats After Myocardial Infarction. Y. Yu, S. Wei, R.M. Weiss, R.B. Felder. University of Iowa and VA Medical Center. E376 844.7 Reduced Sensory Nerve Fiber Density in Ventricular Myocardium in a Rat Myocardial Infarction Heart Failure Model. J. Siano, Y. Li, E.I. Dedkov, Y. Zhang. New York Institute of Technology College of Osteopathic Medicine and Cooper Medical School of Rowan University.
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845. CARDIOPROTECTION Poster (Sponsored by: APS Cardiovascular Section) (Cosponsored by: The Microcirculatory Society) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E377 845.1 Increased CVD Risk Burden Diminishes the Protective Effect of Remote Ischemic Preconditioning Against Endothelial Ischemia-Reperfusion Injury in Humans. G.P. Van Guilder, T. Trachte. South Dakota State University. E378 845.2 Infarct Size Reduction by Remote Ischemic Perconditioning and Humoral Transfer of Protection Across Species. P. Kleinbongard, H. Lieder, S. Gent, A. Skyschally, G. Heusch. University of Essen Medical School, Germany. E379 845.3 Myocardial Vascular Protection in Hibernating Woodchucks. J. Zhang, D.E. Vatner, J. Guers, S.F. Vatner. Rutgers University—New Jersey and Medical School. E380 845.4 Overexpression of SOD2 in Myocytes Protects Mitochondrial Function from Myocardial Ischemia and Reperfusion Injury. P. Lin, Y. Chen. Northeast Ohio Medical University. E381 845.5 Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury. K. Ait-Aissa, J.S. Heisner, J.L. Strande, L. Harmann, A.K. Camara, A.M. Beyer. Medical College of Wisconsin. E382 845.6 Insulin-Like Growth Factor 1 Preserves Cardiac Function After Myocardial Infarction Without Affecting Initial Ischemia and Reperfusion Injury. A. Heinen, R. Nederlof, A. Raupach, H. Reffelt, S. Gödecke, A. Gödecke. HeinrichHeine University, Germany.
846. MYOCARDIAL ISCHEMIA Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E383 846.1 Troponin Degradation Products: More Specific Marker for Myocardial Infarction. S. Zahran, V. Figueiredo, G. Cembrowski, M. Graham, R. Schulz, P. Hwang. University of Alberta, Canada, Univ. Federal de Ouro Preto and Brazil, Brazil. E384 846.2 Transient Rat Cardiac Ischemia from 30–60 Minutes Results in Comparable Left Ventricular Remodeling and Dysfunction. Q. Chen, F. Wright, A. Olzinski, R. Bernard, D. Dwyer, B. Jucker, J. Toomey, C. Schnackenberg. GlaxoSmithKline. E385 846.3 Comparison of Circulating Micrornas and Cardiac Troponin I Following Brief Ischemia-Induced Myocardial Stunning. M.J. Rodman, B.R. Weil, R.F. Young, J.M. Canty; Jr. E386 846.4 Post-Ischemic Cardiac Protection by NADPH Supplementation or CD38 Inhibition Is Dependent on Endothelial Nitric Oxide Synthase (eNOS). J. Boslett, J.L. Zweier. Ohio State University.
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E387 846.5 Taurine Supplementation Improves Arterial Pressure Control Function After Cardiac Ischemia/Reperfusion via Systemic Inhibition of the Renin-Angiotensin System in Adult Female Rats Perinatally Depleted of Taurine and Supplemented with High Sugar. S. Roysommuti, S. Kulthinee, J.M. Wyss. Khon Kaen University, Thailand, Rajabhat Mahasarakham University, Thailand and University of Alabama at Birmingham. E388 846.6 Taurine Supplementation Improves Cardiac Ischemia/Reperfusion Injury by Inhibiting Intra-Cardiac Renin-Angiotensin System Overactivity in Adult Female Rats Perinatally Depleted of Taurine. S. Kulthinee, L.G. Navar, S. Roysommuti. Khon Kaen University, Thailand, Rajabhat Mahasarakham University, Thailand and Tulane University. E389 846.7 Cardiac Ischemic Tolerance of Spontaneously Hypertensive Rats with Increased Expression of C-Reactive Protein. J. Neckar, F. Papousek, J. Silhavy, M. Pravenec, F. Kolar. Institute of Physiology and Czech Academy of Sciences, Czech Republic. E390 846.8 Cardioprotective Role of Regulator of G Protein Signaling 6 in the Ischemic Heart. B.R. Rorabaugh, B. Chakravarti, S.L. Seeley, A.D. Bui, J. Yang, S.W. Watts, R.R. Neubig, R.A. Fisher. Ohio Northern University College of Pharmacy, University of Iowa College of Medicine and Michigan State University. E391 846.9 Longitudinal Strain by Speckle Tracking Imaging Detected Regional Myocardial Dysfunction in a Rat Model of Ischemia-Reperfusion. A.M. Omoto, F.N. Gava, H.B. Silva, M. de Oliveira, C.A. Silva, H.C. Salgado, R. Fazan Jr. School of Medicine of Ribeirão Preto—University of São Paulo, Brazil. E392 846.10 Impact of Methamphetamine on the Ischemic Hearts of Three Generations of Rats. B.R. Rorabaugh, S.L. Seeley, T. Stoops, L. Sprague, A.D. Bui, M. D’Souza. Ohio Northern University College of Pharmacy. E393 846.11 Age-Dependent Mitochondrial Targeting of Protein Kinase C Epsilon in Cardioprotection. C. Kang, J. Qin, W. Osei, K. Hu. The Ohio State University. E394 846.12 Retinoic Acid Regulates Cardiac Progenitor Cell Proliferation and Differentiation. A.J. Favreau-Lessard, R. Rath, S. Duarte, I. Pinz, S. Ryzhov, M. Asson-Batres, D.B. Sawyer. Maine Medical Center Research Institute, University of California Davis, University of Southern Maine and Central Oregon Community College. E395 846.13 Spinal Dorsal Column and Vagus Nerve Stimulation Modulate Vagal Afferent Transduction of Myocardial Ischemia. S. Salavatian, E. Beaumont, J.A. Armour, J.L. Ardell. University of California—Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Biomedical Sciences and East Tennessee State University. E396 846.14 Deficiency of Ataxia-Telangiectasia Mutated Kinase Induces Autophagic Impairment Following Myocardial Infarction. P.R. Thrasher, S.L. Scofield, S. Dalal, M. Singh, K. Singh. East Tennessee State University and James H. Quillen VA Medical Center. E397 846.15 Calcium Inhibition of Oxidative Phosphorylation. J.N. Bazil, Y. Zhang. Michigan State University. E398 846.16 Exogenous Ubiquitin Improves Cardiac Function and Reduces Inflammatory Response Following Myocardial Ischemia/Reperfusion Injury. S.L. Scofield, K.A. Lim, S. Dalal, M. Singh, K. Singh. East Tennessee State University and James H. Quillen VA Medical Center.
MONDAY PHYSIOLOGY E399 846.17 Protein Kinase C Epsilon Peptide Inhibitor Exerts Cardioprotective Effects in Myocardial Ischemia/ Reperfusion Injury. A. McIntyre, C. Adekayode, J. Heron, I. James, J. Woodley, T. Dittakavi, I. Benjamin, S. Liu, Q. Chen, R. Barsotti, L. Young. Philadelphia College of Osteopathic Medicine. E400 846.18 SIRTt1 Activator II Protects Against Myocardial Injury in High Fat Diet-Induced Diabetic Mice. K.M. Boini, S. Raghunathan, B. McConnell, S. Koka. University of Houston. E401 846.19 The Role of Cardiac Lineage Protein 1 (CLP1) on Inflammatory and Fibrotic Responses Following Myocardial Infarction. C. Ghobrial, M. Stewart. SUNY Downstate. E402 846.20 Protective Effects of mTOR Against Ferroptosis, a Form of Iron-Dependent Regulated Cell Death, in Cardiomyocytes. Y. Baba, B.K. Shimada, K.M. Horiuchi, J.K. Higa, T. Matsui. Dept of Anatomy, Biochemistry & Physiology, JABSOM, University of Hawaii at Manoa, Kochi University and Kochi Medical School, Japan. E403 846.21 Bolus Ghrelin Administration Ameliorates the Inflammatory Response and Oxidative Stress During Percutaneous Cardiopulmonary Support in a Rat Model. V. Sukumaran, Y. Fujii, H. Tsuchimochi, M. Shirai, E. Tatsumi, J.T. Pearson. National Cerebral and Cardiovascular Center Research Institute, Japan, Niigata University of Health and Welfare, Japan, Monash Biomedicine Discovery Institute and Monash University, Australia. E404 846.22 Interaction Between Lipid and β-Carotene Metabolism in the Maternal Heart in Mice. C.T. Holloway, Y. Kim, L. Quadro. Rutgers University. E405 846.23 Ginger Treatment Ameliorates Alcohol-Induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats. S.R. Kesireddy, V. Ganjikunta, S. Bhasha, R. Sahukaru. Sri Venkateswara University, India. E406 846.24 Remodeling of Glucose Metabolism by HIF1α in Hypoxic Heart. Y. Li, P. Lin, J.M. Peterson, G.L. Wright. Quillen College of Medicine, East Tennessee State University, University of Kentucky, College of Public Health and East Tennessee State University. E407 846.25 Effects of SanguinateTM on Systemic and Microcirculatory Variables in a Model of Prolonged Ischemic Shock. W.H. Nugent, R.F. Cestero, R. Jubin, A. Abuchowski, B.K. Song. Song Biotechnologies, University of Texas Health Science Center at San Antonio and Prolong Pharmaceuticals.
847. SYMPATHETIC CONTROL OF THE CIRCULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section)
E410 847.3 Individual Variability in Sympathetic Neural Responses to Altitude Exposure: Relationship to Sea Level Sympathetic Nerve Activity. K. Mitchell, K. Bradbury, B.A. Beidleman, C.S. Fulco, S. Muza, A. Posch, N. Charkoudian. USARIEM. E411 847.4 Lower Limb Venous Distension Reflex and Orthostatic Tolerance in Young Healthy Humans. J. Cui, C. Blaha, M.D. Herr, L.I. Sinoway. Pennsylvania State University College of Medicine. E412 847.5 Muscle Metaboreflex Activation in Young Healthy Men with a Family History of Hypertension. J. Kaur, J.R. Vranish, J.C. Patik, B.E. Young, D.M. Keller, P.J. Fadel. University of Texas at Arlington. E413 847.6 Presynaptic Organization of CaV2 Channels with Specific Vesicle Pools in SCG vs Rat Tail Artery. S. Mojard Kalkhoran, J. Walia, C. Gershome, S.H. Chow, D. Poburko. Simon Fraser University, Canada. E414 847.7 Relationships Between Hemodynamic and Sympathetic Neural Responses to Head-Up Tilt During Moderate Dehydration in Humans. A.M. Posch, A. Luippold, K. Mitchell, K. Bradbury, S. Cheuvront, R. Kenefick, N. Charkoudian. USARIEM. E415 847.8 Sixty Days of Head-Down Tilt Bed Rest Augments Muscle Sympathetic Nerve Activity Responses to Maximal End-Inspiratory Apnea: Evaluation of Sympathetic Neural Recruitment Strategies. S.A. Klassen, S. De Abreu, P. Denise, J.K. Shoemaker, H. Normand. Western University, Canada, COMETE, Universite de Caen Normandie and INSERM, France. E416 847.9 Effect of Exercise Training on Neurovascular Control During Mental Stress in Patients with Acute Coronary Syndrome. L. Ferreira-Santos, D.G. Martinez, J. Nicolau, H.G. Moreira, M.N. Alves, I.C. Trombetta, C.E. Negrão, M.P. Rondon. Heart Institute, University of Sao Paulo Medical School and School of Physical Education and Sport, University of Sao Paulo, Brazil, Federal University of Juiz de Fora, Brazil, Heart Institute, University of Sao Paulo Medical School, Brazil, Universidade Nove de Julho, Brazil, School of Physical Education and Sport and University of Sao Paulo, Brazil. E417 847.10 Elevated Sympathetic Nerve Activity Mediates Increases in Large Central Elastic Artery Stiffness Independent of Changes in Blood Pressure in Humans. S.W. Holwerda, D.P. Credeur, L.E. DuBose, R.E. Luehrs, C.E. Schwartz, P.J. Fadel, G.L. Pierce. University of Iowa, University of Southern Mississippi, Michigan Tech and University of Texas at Arlington. E418 847.11 Effect of Arterial Stiffness on Hemodynamic Responses to the Cold Pressor Test in Men and Women. M.A. Tucker, J. Looney, M. Lyon, L.C. Layman, D.M. Pollock, R.A. Harris. Augusta University, University of Alabama at Birmingham and University of Ulster, United Kingdom.
Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E408 847.1 Sympathetic Function During Whole-Body Cooling Is Altered in Hypertensive Adults. J.L. Greaney, W. Kenney, L.M. Alexander. The Pennsylvania State University. E409 847.2 The Effects of 12 Days Exposure to 4,300 m Altitude on the Sympathetic Neural and Cardiovascular Responses to Head-Up Tilt. K.E. Bradbury, K.M. Mitchell, B.A. Beidleman, C.S. Fulco, S.R. Muza, A.M. Posch, N. Charkoudian. USARIEM.
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848. ARTERIAL BAROREFLEX FUNCTION AND BLOOD PRESSURE REGULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E419 848.1 Modulation by NADPH-Ox/Rho-Kinase Signaling of the Cyclosporine-NSAIDs Interactions on Blood Pressure and Baroreflexes in Female Rats. M.M. El-Mas, K.S. Ibrahim, A.F. El-Yazbi, H.M. El-Gowelli. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Alexandria University, Egypt. E420 848.2 Renal Denervation Restores the Baroreflex Regulation of Renal Sympathetic Nerve Acativity In Rats Receiving Intrarenal Bradykinin. S.A. Khan, M. Abdul Sattar, H. Anwer Rathore, A. Ahmad, N. Abdullah, E. John. Universiti Sains Malaysia, Malaysia, Virginia Commonwealth University, University of Malaya, Malaysia and University College Cork, Ireland. E421 848.3 The α7/α4β2 nAChRs Alleviate the Hypotension and Altered Cardiac Sympathovagal Balance Evoked by Endotoxemia in Male Rats. M.Y. Sallam, S.M. ElGowilly, H.M. El-Gowelli, M.M. El-Mas. Faculty of Pharmacy and Alexandria University, Egypt. E422 848.4 Gonadal Hormone Receptors Underlie the Resistance of Female Rats to Cardiovascular Complications of Endotoxemia. M.A. El-Lakany, H.M. El-Gowelli, M.A. Fouda, S.M. El-Gowilly, M.M. El-Mas. E423 848.5 Altered Baroreflex-Mediated Cardiovascular Responses to Acute Hypotension in Heart Failure Patients Compared to Healthy Adults. R.C. Drew, C.N. Lindblad, S.M. Samii, C.A. Blaha, M.J. White, L.I. Sinoway. Penn State College of Medicine, University of Massachusetts Boston and University of Birmingham, United Kingdom. E424 848.6 Device-Guided Slow Breathing Lowers Blood Pressure and Muscle Sympathetic Nerve Activity Acutely in Prehypertensive Patients with Post-Traumatic Stress Disorder (PTSD). J. Park, R. Downey, M. Kankam, S. Norrholm, B. Rothbaum. Emory University and Atlanta VA Medical Center. E425 848.7 Group III/IV Muscle Afferents Contribute to Carotid Baroreflex Resetting During Evoked Contractions in Humans. T.J. Hureau, J.C. Weavil, T.S. Thurston, R.M. Broxterman, A.D. Nelson, A.D. Bledsoe, J.E. Jessop, R.S. Richardson, D. Wray, M. Amann. University of Utah. E426 848.8 Non-Invasive Vagus Nerve Stimulation Acutely Improves Blood Pressure Control in a Placebo Controlled Study. J.L. Sabino-Carvalho, D. Antonino, A.L. Teixeira, P.M. MaiaLopes, A.R. Murray, J. Deuchars, L.C. Vianna. University of Brasília, Brazil and University of Leeds, United Kingdom. E427 848.9 Effects of Nitrous Oxide Sedation on Sympathetic Baroreflex Sensitivity. K. Isono, Y. Okada, T. Mitsui, Y. Higuchi, Y. Masuda, T. Ogasawara. Matsumoto Dental University, Japan. E428 848.10 Impact of Angiotensin Converting Enzyme (ACE) Gene Levels on Baroreflex Impairment and Sympathetic Hyperactivity After a High Fructose Diet. I.C. Moraes-Silva, L.E. de Souza, D.E. Casarini, M. Irigoyen. Heart Institute (InCor), University of São Paulo Medical School, Brazil and Federal University of São Paulo, Brazil.
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E429 848.11 Identification of Open-Loop Baroreflex Gain from Continuous Arterial Pressure Monitoring. H. Mannoji, K. Saku, T. Nishikawa, T. Tohyama, Y. Oga, K. Abe, T. Kishi, H. Tsutsui, K. Sunagawa. Kyushu University, Japan. E430 848.12 Acute and Chronic Increases in Sodium and Cardiac Vagal Baroreflex Sensitivity. M.C. Babcock, J. Watso, M.S. Brian, D.G. Edwards, S.D. Stocker, M.M. Wenner, W.B. Farquhar. University of Delaware and University of Pittsburgh. E431 848.13 Wavelet Analysis of Cardiac Baroreflex Sensitivity During Stepwise Blood Pressure Changes. T. Tarumi, F. Tian, C. Xing, M. Turner, J. Repshas, R. Zhang. Institute for Exercise and Environmental Medicine, UT Southwestern Medical Center, University of Texas at Arlington, Fourth Military Medical University, People’s Republic of China. E432 848.14 Inspiratory Muscle Strength Training for SleepRelated Breathing Disorders. G. Ramos Barrera, R. De Asis, E. Bailey. The University of Arizona. E433 848.15 Tractographic Analysis of the Medulla Oblongata Necessitates Partial Re-Wiring of the Contemporary Neural Circuit for Baroreflex-Mediated Sympathetic Vasomotor Tone. S. Chan. Chang Gung Memorial Hospital, Taiwan.
849. CENTRAL REGULATION OF BODY FLUID HOMEOSTASIS Poster (Sponsored by: APS Central Nervous System Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E434 849.1 Non-Invasive 3-Dimensional Facial Modeling for the Quantification of Facial Edema. B. Smith, B. Crowell, O. Ozgur, E. Goetchuis, N. Newby, J. Scott. University Of Mount Union, MEI Technologies, New York Ear and Eye Infirmary, University of Houston, KBRWyle and University Space Research Association. E435 849.2 A Reduction in SK Channel Function Contributes to Increased Excitability of Hypothalamic Magnocellular Neurons During Heart Failure. H. Candido Ferreira Neto, V. Biancardi, J. Stern. Augusta University and Auburn University. E436 849.3 Chronic Dehydration Induced Changes in Mouse Supraoptic Nucleus (SON): Contribution to Chronic Kidney Diseases (CKD)? Z. Song, C. Roncal, T. Milagres, M. Lanaspa-Garcia, A. Andres-Hernando, R. Johnson. University of Colorado School of Medicine. E437 849.4 Role of Brain Derived Neurotrophic Factor in the Supraoptic Nucleus on Response to Salt Loading. K. Balapattabi, J.T. Little, M. Bachelor, J.T. Cunningham. UNT Health Science Center. E438 849.5 Water Deprivation Does Not Enhance Sympathetic and Pressor Responses to Sciatic Nerve Stimulation or Chemical Activation of RVLM Neurons. S.D. Stocker, M.M. Wenner, W.B. Farquhar. University of Pittsburgh and University of Delaware. E439 849.6 Enhanced Excitability of Vasopressin Neurons in the Supraoptic Nucleus Following 48-hr Water Deprivation. G.E. Farmer, J.T. Little, B. Knapp, J.T. Cunningham. UNT Health Science Center.
MONDAY PHYSIOLOGY
850. SEX DIFFERENCES IN BLOOD PRESSURE AND FLUID VOLUME HOMEOSTASIS Poster (Sponsored by: APS Water and Electrolyte Homeostasis Section ) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E440 850.1 Differential Effect of Testosterone Supplements on Body Composition in Young and Old Male Spontaneously Hypertensive Rats. R.O. Maranon, C. Dalmasso, C.N. Patil, L.L. Yanes Cardozo, L.A. Juncos, J.F. Reckelhoff. UMMC. E441 850.2 Sexual Dimorphic Responses of Renal Transporters to High Salt Diet Favor More Diuresis in Females. L.C. Veiras, H. Lisboa, Z. Khalil, D.L. Ralph, A.A. McDonough. University of Southern California. E442 850.3 The Temporal Effects of DOCA-Salt on the Renal T Cell Profile Is Sex-Specific. J. Hutchinson, E.E. Gillis, G.R. Crislip, J.B. Musall, B. Baban, J.C. Sullivan. Augusta University. E443 850.4 Sex Chromosome Complement Involvement in Vasopressin Gene Expression Induced by Water Deprivation. F. Dadam, A. Mecawi, M. Cambiasso;, J. Antunes-Rodrigues;, L. Vivas, X. Caeiro. Instituto de Investigación médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina, Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto and Universidade de Sao Paulo, Brazil. E444 850.5 IL-10 Supplementation Decreases BP in Male, but Not Female, Spontaneously Hypertensive Rats. E.E. Gillis, J. Hutchinson, J.B. Musall, J.C. Sullivan. Augusta University. E445 850.6 Sex Dependent Effects of Prenatal Nicotine Exposure on Cardiovascular Reactivity: Are Males at a Greater Risk for Cardiovascular Disease? L.F. Hayward, J. Watkins. Univ.of Florida.
851. BLOOD PRESSURE AND FLUID VOLUME REGULATION IN PREGNANCY Poster (Sponsored by: APS Water and Electrolyte Homeostasis Section ) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E446 851.1 Gene Expression Changes and a Decreased Sensitivity for KCl in Aortic Tissue During Experimental Preeclampsia in Rats. S.V. Lip, T. Plösch, M.V. Boekschoten, M.M. Faas. University Medical Center Groningen, Netherlands and Wageningen University, Netherlands. E447 851.2 TNFα and IL-17 Downregulates βENaC Expression and Reduces Migration in Vascular Smooth Muscle Cells. J.W. Duncan, J.P. Warrington, M.J. Ryan, J.P. Granger, H.A. Drummond. University of Mississippi Medical Center.
E448 851.3 Role of Natural Killer Cells as Mediators of Mitochondrial Dysfunction Induced by Placental Ischemia in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia. V. Vaka, K.M. McMaster, M.W. Cunningham, L.M. Amaral, T. Ibrahim, D.C. Cornelius, B. LaMarca. UMMC. E449 851.4 Impact of Placental Ischemia on Cardiac Structure and Function During Pregnancy and PostPartum. B. Bakrania, J.P. Granger. University of Mississippi Medical Center. E450 851.5 Oxidative Stress Drives ECM Shedding in Placental Trophoblasts. A.C. Eddy, H. Chapman, E.M. George. University of Mississippi Medical Center. E451 851.6 A Biopolymer-Stabilized VEGF Chimera Is Maternally Sequestered and Prevents Placental Ischemia Induced Increases in Blood Pressure in the Reduced Uterine Perfusion Pressure Model of Preeclampsia. O. Logue, F. Mahdi, H. Chapman, E.M. George, G.L. Bidwell. University of Mississippi Medical Center. E452 851.7 Validation of LTP Nanoparticles as a Gene Delivery System: Maternal and Fetal Outcomes Unchanged by Delivery of Nonsense Plasmid VEGFR2 Nanoparticles. J. Novak, B.A. Balser, Y.H. Yun, R.J. Ramirez. Walsh University and University of Akron. E453 851.8 Endothelin Receptor Type B (ETB)-Deficient Pregnant Rats Have Exaggerated Placental IschemiaInduced Hypertension. E.A. Dent, F.T. Spradley, J.P. Granger. University of Mississippi Medical Center. E454 851.9 Inhibition of Angiotensin II Type 1 Receptor Agonistic Autoantibody Binding Improves Maternal Outcomes in Rats with Placental Ischemia. M.W. Cunningham; Jr., J. Castillo, V.R. Vaka, L. Amaral, D. Cornelius, F. Spradley, T. Ibrahim, N. Campbell, N. Usry, J. Williams, B. LaMarca. University of Mississippi Medical Center. E455 851.10 Relaxin Contributes to the Regulation of Atrial Pressure During Pregnancy. K.M. Denton, K.M. Mirabito Collafella, C. Samuel. Monash University, Australia and Erasmus Medical Centre, Netherlands. E456 851.11 Time Course of Changes in Calf Venous Compliance During Pregnancy and Postpartum in Humans. R. Parker, J. Yoo, S. Jarvis, Y. Okada, S. Best, A. Stickford, B. Levine, Q. Fu. Institute for Exercise and Environment and University of Texas Southwestern Medical Center.
852. DEVELOPMENTAL PROGRAMMING AND CARDIO-RENAL FUNCTION IN ADULTS Poster (Sponsored by: APS Water and Electrolyte Homeostasis Section ) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E457 852.1 Effect of Maternal Antioxidant MitoQ Treatment on Offspring Cardiovascular Function in a Rat Model of Intrauterine Growth Restriction (IUGR). M.M. Aljunaidy, J.S. Morton, R. Kirschenman, P. Case, C. Cooke, S.T. Davidge. University of Alberta, Canada and University of Bristol, United Kingdom. E458 852.2 Obesity-Induced Hypertension Is Associated with Increases in Adipose Tissue-Derived Angiotensinogen in Female Mice Exposed to Early Life Stress (ELS). J. Herald, M. Murphy, D. Cohn, A. Loria. University of Kentucky.
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PHYSIOLOGY MONDAY E459 852.3 Chronic Activation of the MAP Kinase Pathway in Isolated Proximal Tubules of Adult Male Sheep with Antenatal Glucocorticoid Exposure. M.C. Chappell, B.A. Wilson, Y. Su, J.C. Rose. Wake Forest University School of Medidicne, University of North Carolina and Wake Forest School of Medicine. E460 852.4 Intrauterine Growth Restriction Programs Greater Susceptibility to Chronic Kidney Injury in Male and Female Aged Rats. A.D. Newsome, G.K. Davis, B.T. Alexander. University of Mississippi Medical Center. E461 852.5 The Androgen Receptor Contributes to Hypertension in Ovariectomized IUGR but Not in Ovariectomized Control Rats. G.K. Davis, A.D. Newsome, B.T. Alexander. University of Mississippi Medical Center. E462 852.6 Effect of Advanced Maternal Age on Cardiovascular Function in Adult Male and Female Rat Offspring. A. Shah, A.S. Care, C.L. Cooke, J.S. Morton, A. Quon, R. Kirschenman, S.T. Davidge. Department of Obstetrics and Gynecology, University of Alberta, Canada, Women and Children’s Health Research Institute, University of Alberta, Canada, Cardiovascular Research Center, University of Alberta, Canada, Department of Physiology and University of Alberta, Canada. E463 852.7 Maternal High Fat-High Sucrose Diet Is Associated with Elevated Offspring Hypothalamic Oxidative Stress and Blood Pressure Responses to Psychological Stress. S. Jayaratne, L. Prestipino, J.W. Polson. University of Sydney, Australia. E464 852.8 Adult Males of Very Low Birth Weight with Antenatal Corticosteroid Exposure Exhibit an Enhanced Blood Pressure Response to Acute Stress. L. Washburn, M. Chappell, D. Beavers, D. Diz, E. Jensen, P. Nixon, H. Shaltout, A. South, R. Taylor, J. Rose. Wake Forest School of Medicine and Wake Forest University.
853. CARDIOVASCULAR AND RENAL MECHANISMS IN DIABETES AND METABOLIC SYNDROME Poster (Sponsored by: APS Water and Electrolyte Homeostasis Section ) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E465 853.1 Physiological Significance of Angiotensin AT1A Receptors in Vasopressin-Producing Cells. D.W. Linggonegoro, J.A. Sandgren, K.E. Claflin, K.J. Perschbacher, J. Ni, N.A. Pearson, G.L. Pierce, M.K. Santillan, J.L. Grobe. E466 853.2 A Role for Sweet Taste Receptors (T1R2/T1R3) in Fructose-Induced Increase in NKCC2 Phosphorylation in Thick Ascending Limbs (TALS). K.M. Kassem, G. Ares, P. Ortiz. Henry Ford Health System. E467 853.3 Endogenous Annexin-A1 Is a Protective Determinant in HFD-Induced Insulin Resistance and Diabetic Nephropathy. G.S. Purvis, F. Chiazza, M. Collino, E. Solito, C. Thiemermann. Queen Mary University of London, United Kingdom and University of Turin, Italy. E468 853.4 The Anti-Contractile Effect of Perivascular Adipose Tissue Is Maintained in Female Dahl Salt-Sensitive Rats in Response to a High-Fat Diet Despite Increases in Blood Pressure and Vascular Inflammation. L.E. Taylor, E. Gilllis, H. Ocasio, B. Baban, J.C. Sullivan. Augusta University.
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E469 853.5 The Reactive Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL) Is a Potent Inducer of Collagen Secretion in Human Cardiac Fibroblasts. T. Monroe, E.J. Anderson. Brody School of Medicine, East Carolina University, College of Pharmacy, Fraternal Order of Eagles Diabetes Research Center and University of Iowa. E470 853.6 ETb Receptor Dysfunction Leads to Exaggerated Apoptosis and Inflammasome Priming in Renal Outer Medulla During Type 1 Diabetes. C. De Miguel, X. Liu, D.M. Pollock, J.S. Pollock. University of Alabama at Birmingham. E471 853.7 Fructose Induces Metabolic Syndrome Associated with a Marked Inflammatory State. F. Santos, E.D. Moreira, K. De Angelis, M. Irigoyen. Heart Institute of Medicine School of Sao Paulo University, Brazil and Nove de Julho University, Brazil. E472 853.8 Exendin-4, a Glucagon-Like Peptide 1 (GLP-1) Agonist, Attenuates Vascular Dysfunction in Type 2 Diabetes (T2DM) via Anti-Inflammatory and Antioxidant Effects. E.B. Asher, K. Vinokur, S. Benerofe, M. Carrillo-Sepulveda. NYIT College of Osteopathic Medicine. E473 853.9 Mechanisms of Vascular Endothelial Dysfunction: The Problem with Sugar and Artificial Sweeteners. B.R. Hoffmann, A.S. Greene. Medical College of Wisconsin and Marquette University. E474 853.10 Chronic Central Leptin Infusion Improves Cardiac Function in Diabetic Rats with Heart Failure. A.A. da Silva, F.N. Gava, R.M. Lataro, C.A. Silva, D.P. Rodrigues, T. Guida, J.M. do Carmo, H.C. Salgado. School of Medicine—Barão de Mauá University Center, Brazil, School of Medicine—Universidade de São Paulo, Brazil and University of Mississippi Medical Center.
854. RAS, ION TRANSPORT, AND VASCULAR DISEASE: GENES AND FUNCTION Poster (Sponsored by: APS Physiological Genomics Group) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E475 854.1 A Genome-Spanning Map of Chromatin Structure Near the Renin Proximal Promoter. T. Stodola, P. Liu, Y. Liu, A. Greene, M. Liang. Medical College of Wisconsin. E476 854.2 Evidence for Mitochondrial AT2 ReceptorMediated Inhibition of Intracellular Angiotensin II-Induced Respiratory and Glycolytic Responses in Mouse Proximal Tubule Cells. X.C. Li, J.L. Zhuo. University of Mississippi Medical Center. E477 854.3 Angiotensin Converting Enzyme Enhances the Oxidative Response and Bactericidal Activity of Neutrophils. K.E. Bernstein, Z. Khan, X.Z. Shen, E.A. Bernstein, J.F. Giani, M. Eriguchi, T.V. Zhao, R.A. Gonzalez-Villalobos, S. Fuchs, G.Y. Liu. Cedars-Sinai Medical Center, Zhejiang University School of Medicine, People’s Republic of China, Pfizer and Western University. E478 854.4 Central Angiotensin II Modulation of HypoxiaInducible Factor (HIF)-1 Alpha in the PVN: Possible Mechanism for Sympathetic Activation. A. Haibara, N. Sharma, H. Zheng, X. Liu, K.P. Patel. University of Minas Gerais, Brazil and University of Nebraska Medical Center.
MONDAY PHYSIOLOGY E479 854.5 Brain Angiotensin Type 2 Receptor (AT2R) Distribution and Role in Fear Memory. Z. Yu, E.G. Krause, P.J. Marvar. George Washington University and University of Florida. E480 854.6 Disorder of Renin-Angiotensin System Promoting the Acute Pulmonary Inflammation by Particulate Matter 2.5 (PM2.5) Exposure. C. Lin, G. Wang, C. Cho, H. Wu, W. Hsieh, C. Lin. National Chiao Tung University, Taiwan, National Chia Yi University, Taiwan and Hsinchu Mackay Memorial Hospital, Taiwan. E481 854.7 HNF1B as a New Transcriptional Activator of the Renal KIR4.1/KIR5.1 Potassium Channel. A. Kompatscher, J.H. de Baaij, K. Aboudehen, A.P. Hoefnagels, P. Igarashi, R.J. Bindels, G.J. Veenstra, J.G. Hoenderop. Radboud Institute for Molecular Life Sciences, Radboudumc, Netherlands, University Minnesota Medical School, Radboud Institute for Molecular Life Sciences and Radboud University Nijmegen, Netherlands. E482 854.8 Kir5.1 Binds to Nedd4-2 and Is Essential for Mediating Nedd4-2-Mediated Down-Regulation of Kir4.1. D. Lin, M. Wang, X. Su, O. Staub, W. Wang, P. Wu, Z. Gao. New York Medical College and University of Lausanne, Switzerland. E483 854.9 The Role of CD70 in Vascular Function. H.A. Itani, A. Pandey, J.D. Brown, D.G. Harrison. Vanderbilt University Medical Center.
855. THE KIDNEY IN HYPERTENSION Poster (Sponsored by: APS Renal Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E484 855.1 Sodium Chloride Cotransporter Upregulation in Settings of Zinc Deficiency Offers New Insight Into Blood Pressure Dysregulation in Chronic Diseases. C.R. Williams, M. Mistry, R. Mallick, A. Mistry, B. Ko, J.L. Gooch, R.S. Hoover. Emory University, Atlanta VA Medical Center and The University of Chicago Medicine. E485 855.2 Sex Differences in Blood Pressure and mRNA Expression of Renal Sodium Transporters in Mice Under Normal Sodium Diet. C. Waturuocha, L. Fan, L. Kudo, W. Gilbert, A. Rouch. OSU-CHS. E486 855.3 Linking Epigenetic Regulation of Short Chain Fatty Acid Receptors, Gut Microbiome and Hydrogen Sulfide in the Hypertensive Kidney. G. Weber, S. Pushpakumar, U. Sen. University of Louisville. E487 855.4 Exaggerated Salt-Sensitive Hypertension in the ALMS1 (Alstrom Syndrome 1) Knockout Rat. K.N. KingMedina, A. Jaykumar, P. Ortiz. Wayne State University and Henry Ford Health System. E488 855.5 Attenuated Cardiovascular-Renal Sensitivity of Blood Pressure and Heart Rate to Infused Insulin in Obese TallyHo/Jng Mice. A. Alunan, L. Li, H. Lee, M. Fluitt, S. Tiwari, C.M. Ecelbarger. Willamette University, Georgetown University and Sanjay Gandhi Post-Graduate Institute of Medical Sciences, India. E489 855.6 Temporal Progression of Salt-Sensitivity in Hsd11b2 Knockout Rat. L.J. Mullins, J. Ivy, M. Bailey, C. Kenyon, J.J. Mullins. University of Edinburgh, United Kingdom.
E490 855.7 Thick Ascending Limb-Derived TNF Production Regulates the Blood Pressure Response to High NaCl Intake. N.R. Ferreri, S. Hao. New York Medical College. E491 855.8 The Role of Atrial Natriuretic Peptide in the Development of Renal and Cardiac Damage in a Dahl SS Rat Model. D. Ilatovskaya, K. Winsor, V. Levchenko, O. Prudnikov, G. Blass, A. Kriegel, A. Staruschenko. Medical College of Wisconsin. E492 855.9 Inactivation of Hv1 Proton Channels Is Not Responsible for Bicarbonate-Mediated Reductions in Tubular Cast Formation in Dahl Salt-Sensitive Rats. S. Ray, H. Ocasio, J. Sun, P.M. O’Connor. Augusta University. E493 855.10 Novel Cardiorenal Effects of the Lactate Receptor GPR81 Activation. N.K. Jones, K. Wallenius, R.I. Menzies, K. Stewart, J.J. Mullins, M.A. Bailey. University of Edinburgh, United Kingdom and AstraZeneca, Sweden. E494 855.11 Sodium Butyrate Suppresses Angiotensin II-Induced Hypertension by Inhibition of Renal (Pro)Renin Receptor and Intrarenal RAS. L. Wang, Q. Zhu, A. Lu, L. Zhang, C. Xu, X. Liu, T. Yang. Sun Yat-sen University School of Medicine, People’s Republic of China, and University of Utah and Veterans Affairs Medical Center. E495 855.12 Establishment of Salt-Induced Chronic Kidney Disease in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) and Its Therapeutic Effect of Kefir-Derived Peptides Oral Administration. Y. Chen, H. Chen, C. Chen. Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University and National Health Research Institutes, Taiwan, Phermpep Co. Ltd., Taiwan, Department of Life Sciences and National Chung Hsing University, Taiwan. E496 855.13 Loss of Bmal1 Impairs the Diurnal Rhythm in Sodium Excretion That Parallels the Loss of Circadian Blood Pressure Rhythm. D. Zhang, G. Najarro, D. Chen, I. Obi, C. Jin, J. Speed, J. Pollock, D. Pollock. University of Alabama at Birmingham and University of California at Merced. E497 855.14 Sodium Butyrate Protects Against Renal Injury in DOCA Salt Hypertensive Rats. Q. Zhu, L. Wang, L. Zhang, A. Lu, T. Yang. Zhongshan School of Medicine, Sun Yat-sen University, People’s Republic of China, Department of Internal Medicine and University of Utah and Veterans Affairs Medical Center. E498 855.15 Inhibition of mTORC1 Signaling Pathway Attenuates the Salt-Induced Hypertension in Dahl SS Rats. V. Kumar, A.W. Cowley Jr. Medical College of Wisconsin. E499 855.16 Aldosterone-Regulated miRNAs and Their Target Genes in Mouse Cortical Collecting Duct MpkCCD Cells. T. Kwon, E. Park, H. Jung, H. Choi. School of Medicine, Kyungpook National University, Republic of Korea, and NIH. E500 855.17 Synergetic Effects of Hypokalemia and Volume Contraction Combine to Drive Paracrine Secretion of αKG. P.R. Grimm, P.A. Welling. University of Maryland School of Medicine. E501 855.18 Dasatinib, a Non-Receptor Tyrosine Kinase Inhibitor, Induces Aquaporin-2 Membrane Accumulation in a Phospho-Serine 256 Independent Manner. R. Bouley, P.W. Cheung, A. Terlouw, D. Brown. MGH. E502 855.19 Renal-Specific Dendritic Cell Depletion Reduces Urinary Interleukin 6 Levels Following Angiotensin II-Mediated Hypertension and Dietary High Salt. B.M. Wynne, G.G. Hecht, T.A. Kronk, H. van Elst, M. Tansey, D.C. Eaton, R.S. Hoover. Emory University and Atlanta VA Medical Center.
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PHYSIOLOGY MONDAY E503 855.20 Sex Differences in Renal Sphingosine1-Phosphate Signaling Pathway and Blood Pressure of Intrauterine Growth Restricted Mice. C.E. Perez de Lara Rodriguez, S. Intapad. Tulane University.
856. EPITHELIAL TRANSPORT GROUP II Poster (Sponsored by: APS Epithelial Transport Group) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E504 856.1 Large Conductance Potassium (KCa1.1) Channel Mediated Potassium Secretion Provides the Driving Force for Water Secretion in Organoids from Rat Distal Colon. T. Rottgen, D. Nickerson, E. Minor, V.M. Rajendran. West Virginia University. E505 856.2 Endoplasmic Reticulum Associated Degradation (ERAD) of the Renal Outer Medullary Potassium Channel, ROMK, Underlies Type II Bartter Syndrome. B.M. O’Donnell, T. Mackie, A. Subramanya, J. Brodsky. University of Pittsburgh. E506 856.3 The Epithelial Sodium Channel (ENaC) α- and γ-Subunits Are Cleaved by Furin in Human Kidney. R.Z. Langkilde, M.K. Mikkelsen, K. Skjødt, R. Zamani, N. Marcussen, B. Jensen, P. Svenningsen. University of Southern Denmark, nstitute of Molecular Medicine, Denmark, Institute of Molecular Medicine, Denmark, Odense University Hospital, Denmark, University of Southern Denmark and Odense University Hospital, Denmark. E507 856.4 The Epsilon Subunit of Epithelial Sodium Channels in Xenopus laevis Prevents Channel Activation by Proteolytic Cleavage. L. Wichmann, K. Vowinkel, M. Althaus. Justus-Liebig-University, Germany and Saarland University School of Medicine, Germany. E508 856.5 Activation of the Epithelial Sodium Channel (ENaC) by Aldosterone in mCCDcl1 Mouse Renal Cortical Collecting Duct Cells Is Dependent on SGK1 and Can Be Prevented by Inhibiting Endogenous Proteases. C. Korbmacher, M.K. Mansley, M. Bertog. Friedrich-AlexanderUniversität Erlangen-Nürnberg (FAU), Germany. E509 856.6 Modularity in the ENaC/Degenerin Family Facilitates Transfer of Functional Properties Between Family Members. M.A. DeMarco, X. Wang, D.M. Balchak, K. Powell, A. Mukherjee, B.M. Blobner, O.B. Kashlan. University of Pittsburgh. E510 856.7 WNK1 Is an Ancient Cell Volume Regulator That Was Repurposed for Terrestrial Evolution. H. Namboodiri, N. Clark, O.B. Kashlan, A.R. Subramanya. University of Pittsburgh. E511 856.8 A Cysteine-Rich Hydrophobic Motif in KSWNK1 Regulates WNK Body Formation. C.R. Boyd-Shiwarski, D.J. Shiwarski, L.J. Nkashama, A. Roy, D.B. Stolz, M. Puthenveedu, A.R. Subramanya. University of Pittsburgh and Carnegie Mellon University.
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E512 856.9 Studying Na-K-2Cl Cotransporter 1 Membrane Dynamic in Mouse Colon in Vivo. P.G. Bouyer, X. Tang, K. Bridgmon, J. Smallwood, K.S. Matlin, J.B. Matthews. University of Chicago and Valparaiso University. E513 856.10 Regulated Expression of the Na+/K+-ATPase Pump in Colonic Epithelium by Bile Acids. J.F. Borg, J. Yde, Q. Wu, N. Lajczak, S. Keely, R.A. Fenton, H. Moeller. Aarhus University, Denmark and Royal College of Surgeons in Ireland, Ireland. E514 856.11 Adaptation to Potassium Depletion in Human: Role of Progesterone? G. Crambert, S. Brailly-Tabard, D. Bergerot, V. Zhygalina, A. Lorthioir, A. Jacques, D. Hourton, M. Azizi, G. Escher, A. Blanchard. Centre de Recherche des Cordeliers, INSERM U1138, CNRS ERL8228, France, APHP, France and Universitätsspital Bern/Inselspital, France. E515 856.12 Novel Calcium Transport Pathways Mediate Intestinal Calcium Absorption Pre-Weaning. M.R. Beggs, J.J. Lee, R. Alexander. University of Alberta, Canada. E516 856.13 Intracellular Cl- and the Scaffold Protein Mo25/ Cab39 Regulate WNK-SPAK/OSR1 Signaling in Transepithelial Ion Transport. A. Rodan, Y. Wu, Q. Sun, J. Humphreys, J. Schellinger, E. Goldsmith. University of Utah and University of Texas Southwestern. E517 856.14 Dietary K+ and Cl- Independently Regulate Basolateral Conductance in the Principal and Intercalated Cells of the Collecting Duct. O. Zaika, V. Tomilin, M. Mamenko, O. Pochynyuk. UTHSCH. E518 856.15 A Novel Na+ Transport System in the A-Type Intercalated Cells of the CCD That Mediates Na+ Secretion Through a H/K-ATPase Type 2-Dependent Pathway. A. Edwards, L. Morla, C. Walter, A. Doucet, G. Crambert. Centre de Recherche des Cordeliers - INSERM U1138 - CNRS ERL8228, France and Boston University. E519 856.16 Stimulation of Sweet Taste Receptors Expressed in the Kidney Enhance Surface NKCC2 Levels in Thick Ascending Limbs (TALs). G. Ares, P. Caceres, K.M. Kassem, P.A. Ortiz. Henry Ford Health System. E520 856.17 Forskolin (cAMP) Promotes Insertion of Large Conductance Potassium (KCa1.1) Channels Into Apical Membranes of Rat Distal Colon. A. Nickerson, T. Rottgen, E. Minor, V.M. Rajendran. West Virginia University. E521 856.18 Rapid LPS Transport During Fat Absorption in Rat Small Intestine. Y. Akiba, I. Kaji, K. Maruta, J.D. Kaunitz. UCLA & WLA VAMC and West LA VAMC. E522 856.19 Human Derived Gut Microbiota Modulates Colonic Secretion in Mice by Regulating 5-HT3 Receptor Expression. Y. Bhattarai, B.A. Schmidt, D.R. Linden, J. Rainey, A. Beyder, E. Larson, M. Grover, G. Farrugia, P. Kashyap. Mayo Clinic. E523 856.20 Intestine-Specific Dual Oxidase Deficiency Lacks ATP-P2Y-Mediated Luminal H2O2 Production in Mice. K. Maruta, Y. Akiba, I. Kaji, J.D. Kaunitz. UCLA & WLA VAMC.
MONDAY PHYSIOLOGY
857. RENAL TUBULAR TRANSPORT, BIOLOGY, AND REGULATION Poster (Sponsored by: APS Renal Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E524 857.1 Kir4.1 Is a Potassium (K) Sensor and Mediates the Effect of Dietary K Intake on NCC Activity in the Distal Convoluted Tubule (DCT). X. Su, C.C. Gallardo, M. Wang, P. Wu, Z. Gao, D. Lin, J.A. McCormick, C. Yang, D.H. Ellison, W. Wang. New York Medical College and Oregon Health and Science University. E525 857.2 Withdrawn. E526 857.3 Vasopressin and Oxytocin in Regulation of Renal Cation and Water Excretion: Nephrone–Kidney Interaction. D. Golosova. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Russian Federation. E527 857.4 NADPH Oxidase 4 Mediates ROS-Induced NKCC2 Activity in Thick Ascending Limbs. F. Saez, J. Garvin. Case Western Reserve University. E528 857.5 NBCe1-A Is Not the Only NBCe1 (SLC4A4) Isoform Expressed in the Mouse Kidney. J.W. Verlander, C. Chen, H. Lee, G. Osis, L. Fang, A. Chen, H.L. Holmes, M.F. Romero, I.D. Weiner. University of Florida, Mayo Clinic and NF/SGVHS. E529 857.6 Segmental and Cellular V1a Receptor Distribution in the Mammalian Kidney. T. Giesecke, Y. Giesecke, K. Kawahara, T. Koshimizu, N. Gimber, J. Schmoranzer, A. Smorodchenko, S. Bachmann, K. Mutig. Charité-Universitätsmedizin Berlin, Germany, University of St Andrews, United Kingdom, Kitasato University School of Medicine, Japan and Jichi Medical University, Japan. E530 857.7 Flow Stimulation of Endothelin-1 Production by the Collecting Duct: Role of Nitric Oxide and Reactive Oxygen Species. D.E. Kohan, W. Wheatley. University of Utah. E531 857.8 ROMK Is Required for the Net K Secretion in the Thick Ascending Limb of Mice on a Low Na High K Diet. B. Wang, H. Li, J. Wang-France, C. Bales, D. Wen, S. Sansom. University of Nebraska Medical Center. E532 857.9 Deletion of Xenotropic and Polytropic Retrovirus Receptor 1 in Mouse Nephron Causes Renal Fanconi Syndrome and Hypophosphatemic Rickets. C. Ansermet, M. Moor, G. Centeno, M. Auberson, D. Hu, R. Barron, S. Nikolaeva, B. Haenzi, N. Katanaeva, I. Gautschi, V. Katanaev, S. Rotman, R. Koesters, L. Schild, S. Pradervand, O. Bonny, D. Firsov. Université de Lausanne, Switzerland, Harvard School of Dental Medicine, Institute of Evolutionary Physiology and Biochemistry, Russian Federation, University Hospital of Lausanne, Switzerland and Université Pierre et Marie Curie, France. E533 857.10 Acute Aldosterone-Mediated Signaling Networks in Distal Convoluted Tubules. L. Cheng, Q. Wu, E.T. Olesen, L. Peng, T. Pisitkun, R. Fenton. Aarhus University, Denmark, Univeristy of Copenhagen, Denmark and Chulalongkorn University, Thailand.
E534 857.11 Important Role for the Mammalian-Target-ofRapamycin (mTOR) in the Collecting Duct as a Determinant of Transporter/Channel Profile and Function. A.L. Brown, H. Lee, S. Tiwari, L. Li, C.M. Ecelbarger. Georgetown University and Sanjay Gandhi Post-Graduate Institute of Medical Sciences, India. E535 857.12 Chronic Loop Diuretic Treatment Mediates Segment-Specific Hypertrophy in the Nephron. A. Krauson, E. Walczak, S. Iyer, N. Velarde, J. Nizar, V. Bhalla. Stanford University and BD Genomics. E536 857.13 Renal Handling of Potassium in the Type 2 Bartter’s Mouse on a Low Na, High K Diet (LNaHK). J. WangFrance, B. Wang, H. Li, S. Sansom. University of Nebraska Medical Center. E537 857.14 Renal CUL3 Haploinsufficiency Is Not Sufficient to Cause Familial Hyperkalemic Hypertension. M.Z. Ferdaus, L. Agbor, C. Sigmund, J. McCormick. Oregon Health & Science University (OHSU) and University of Iowa. E538 857.15 The 70 pS Inward Rectifying K Channel Is Identified as Renal Outer Medullary K Channels (ROMK) on Rough, but Not Smooth, Thick Ascending Limb Cells (TAL). H. Li, B. wang, j. Wang-France, C. Bayles, J.W. Verlander, S.C. Sansom. University of Nebraska Medical Center and College of Medicine Electron Microscopy Core University of Florida. E539 857.16 Ex Vivo Quantification of pHi in Drosophila Malpighian Tubule Principal Cells Reveals Basolateral H+ Equivalent—Coupled Oxalate Transport Through Likely Slc26a1 Ortholog. A.J. Rossano, J.B. Anderson, M.F. Romero. Mayo Clinic College of Medicine. E540 857.17 Aldosterone-Induced Na+ Absorption Is Regulated by Protein Acetylation in a Cellular Model of the Cortical Collecting Duct. M.K. Mansley, A.J. Roe, S.L. Francis, J.H. Gill, M.A. Bailey, S.M. Wilson. Durham University, United Kingdom and The University of Edinburgh, United Kingdom. E541 857.18 Characterisation of a Mouse Kidney Cortical Collecting Duct Cell Line Suggests Plasticity Between Cell Types. A.M. Assmus, M.K. Mansley, L.J. Mullins, A. Peter, J.J. Mullins. Centre for Cardiovascular Science and University of Edinburgh, United Kingdom. E542 857.19 Alpha-Ketoglutarate Stimulates Cl- Absorption in the Mouse CCD Through a Mechanism Dependent on Pendrin and Protein Kinase C. Y. Lazo Fernandez, P.A. Welling, S.M. Wall. Emory University School of Medicine and University of Maryland Medical School. E543 857.20 A Heterozygous de Novo Mutation in SLC41A1 Causes Hypomagnesemia and Renal Magnesium Wasting. J.H. de Baaij, F.J. Arjona, K.P. Schlingmann, S. Burtey, M. Thomassen, J. van der Wijst, N.V. Knoers, R.J. Bindels, M. Konrad, J.G. Hoenderop. Radboud University Medical Center, Netherlands, University of Münster, Germany, Vascular Research Center Marseille, France and University of Utrecht, Netherlands. E544 857.21 Calcium-Mediated Activation of the BK K+ Secretory Channel in Collecting Duct Cells Is Dynamically Regulated by the Ca2+-Activated SK3 and IK1 K+ Channels. Y. Li, H. Hu, J. Tian, M. Zhu, R. O’Neil. University of Texas and Health Science Center at Houston. E545 857.22 Reversible Modulation of the Proximal Tubule Apical Endocytic Pathway by Fluid Shear-Stress. K.E. Shipman, K.R. Long, Y. Rbaibi, C.J. Baty, O.A. Weisz. University of Pittsburgh.
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PHYSIOLOGY MONDAY E546 857.23 Proximal Tubule Glutamine Synthetase Is Critical for the Response to Low Protein Diet. I.D. Weiner, H. Lee, G. Osis, M.E. Handlogten, C. Chen, J.W. Verlander. University of Florida and NF/SGVHS. E547 857.24 Molecular Analysis of Exosomes from Mouse Kidney Collecting Duct Cells. V.D. Dang, K.K. Jella, D.S. Montgomery, N. Denslow, A.A. Alli. University of Florida, Emory University School of Medicine and University of Florida College of Medicine. E548 857.25 Role of Sodium Hydrogen Exchange Regulatory Factor-1 (NHERF1) in Aging: Tale of Two Rat Models. A. Ahmad, S. Pushpakumar, C.J. Ketchem, U. Sen, E.D. Lederer, S.J. Khundmiri. Howard University, University of Louisville and Robley Rex VAMC. E549 857.26 Deletion of ALMS1 (Alstrom Syndrome 1) Enhances Salt-Sensitive Hypertension and Induces Insulin Resistance and Obesity in Rats. A. Jaykumar, P. Caceres, E.L. Henson, W.H. Beierwaltes, P.A. Ortiz. Wayne State University and Henry Ford Hospital. E550 857.27 Novel Mechanism of Salt-Sensitive Hypertension: CD8+ T Cells Stimulate Sodium Chloride Co-Transporter NCC in Kidney. S. Mu, Y. Liu. University of Arkansas for Medical Sciences. E551 857.28 Assessing the Role of OCRL1 in Proximal Tubule Function in a Lowe Syndrome Cell Model. M.L. Eshbach, K.E. Shipman, V. Raghavan, Y. Rbaibi, K.R. Long, A. Labilloy, C.J. Baty, O.A. Weisz. University of Pittsburgh. E552 857.29 Comparative Proteomic Analysis of Kidney Distal Convoluted Tubule and Cortical Collecting Duct Cells Following Long-Term Hormonal Stimulation. Q. Wu, H. Møller, L.L. Rosenbæk, T. Pisitkun, R.A. Fenton. Aarhus University, Denmark, University of Copenhagen, Denmark and Chulalongkorn University, Thailand. E553 857.30 Expression of UT-B Urea Transporters in the RT4 Urothelial Cell Line. G. Stewart, A. Farrell. University College Dublin, Ireland. E554 857.31 Nuclear Factor-κB Mediates Zinc DeficiencyInduced Sodium Chloride Cotransporter Upregulation in Mouse Distal Convoluted Tubular Cells. M.K. Naraine, M.S. Li, J. Williams, M. Mistry, R.S. Hoover, C.R. Williams. Emory University. E555 857.32 Alternative Splice Variant of the ThiazideSensitive NaCl Cotransporter: The Dominant Role of the Novel Phosphorylation Site S811. O. Tutakhel, J.G. Hoederop, R.J. Bindels. Radboud University Medical Center (RUMC), Netherlands. E556 857.33 Corticosterone Activates the Thiazide-Sensitive NaCl Transporter Through the Glucocorticoid Receptor. M.A. Bailey, J.R. Ivy. University of Edinburgh, United Kingdom.
858. CELL VOLUME, OSMOREGULATION, AND WATER TRANSPORT Poster (Sponsored by: APS Cell and Molecular Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E557 858.1 Measuring Intracellular Protein Concentration: Why and How? P. Rana. Kent State University.
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859. STRESS AND PHYSIOLOGICAL RESPONSES THROUGHOUT LIFE Poster (Sponsored by: APS Water and Electrolyte Homeostasis Section ) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E558 859.1 High sFlt-1 Concentrations During Pregnancy Modulate the Ppara Promoter Methylation in the Fetal Liver. V. Stojanovska, K. Holwerda, A. van der Graaf, M. Boekschoten, M. Faas, S. Scherjon, T. Plösch. University Medical Center Groningen, Netherlands and University of Wageningen, Netherlands. E559 859.2 Stress and Insufficient Nutrition Program Abnormal Growth of the Embryo. H. Nishimura, E. Yaoita, M.S. Sequeira Lopez. Niigata University Graduate School of Medical and Dental Sciences, Japan and University of Virginia Child Health Research Center. E560 859.3 High Fat Diet Exacerbates Adipose TissueDerived Adipokines and Hypertension in Female C57BL/6 Mice Exposed to Early Life Stress (ELS). A. Loria, M.O. Murphy, J. Herald, D. Cohn. University of Kentucky. E561 859.4 Sympathetic Nerves Promote HypertensionSpecific CD8+ Effector Memory T Cell Homing in the Bone Marrow of Mice with Angiotensin II Infusion. L. Xiao, H.A. Itani, J.D. Foss, D.G. Harrison. Vanderbilt University Medical Center. (358.4) E562 859.5 Identification of a Stress-Inhibitory Pathway from the Nucleus of the Solitary Tract (NTS) to the Bed Nucleus of the Stria Terminalis (BNST). D. Scheuer, H. Hiller, M. McCowan, L. Wang, E.G. Krause. University of Florida and University of North Texas Health Science Center. E563 859.6 Role of UCP2 on Mitochondrial Dysfunction in the Renal Oxidative Stress-Mediated Hypertension Associated with DJ-1 Depletion. C. De Miguel, W.C. Hamrick, S. Jagarlamudi, L. Assico, P.A. Jose, S. Cuevas. University of Alabama at Birmingham and The George Washington University. E564 859.7 Psychosocial Stress Exacerbates Disease Outcome in Mice with Muscular Dystrophy. R. Sabharwal, M. Poglitsch, L. Yang, R.M. Weiss. University of Iowa and Attoquant Diagnostics, Austria. E565 859.8 Influence of Parental Dietary Protein Source on Dahl Salt-Sensitive Hypertension and Renal Disease. J.M. Abais-Battad, H. Lund, D.L. Mattson. Medical College of Wisconsin. E566 859.9 Hemorrhagic Shock and Fluid Resuscitation Alter Gene Expression of Chromatin Modification Enzymes in Thoracic Aorta of Swine (Sus scrofa). D.H. Ho, C.A. Hernandez, W.M. Ichimura, L.M. Murata, C.F. Uyehara. Tripler Army Medical Center. E567 859.10 Impact of Exercise on Stress Responses and Memory in an Undergraduate Student Population. A.I. Carranco, J.M. Monthony, S.A. Mumtaz, L.C. Morton, D.J. Burns, B.D. Cohen. Union College. E568 859.11 Early Life Stress (ELS) Induces Arginase 1 Gene Expression in the Renal Cortex of Adult Male Rats Under High Salt Diet. I.E. Obi, J.S. Pollock. University of Alabama at Birmingham.
MONDAY PHYSIOLOGY E569 859.12 Central Angiotensin Type 2 Receptor (AT2R) Stimulation Promotes Enhanced Extinction of Fear Learning Independent of Cardiovascular Measures. A.P. Swiercz, J.P. Wiaderkiewicz, C. Moshfegh, L. Hopkins, P.J. Marvar. George Washington University and Rosalind Franklin University of Medicine and Science.
860. MATHEMATICAL MODELS OF ORGAN SYSTEMS, TISSUES OR CELLS Poster (Sponsored by: Biomedical Engineering Society)
E580 860.11 Relating Preload Recruitable Stroke Work to Parameters Characterizing Systolic and Diastolic Cardiac Function. I.M. Stoute, L.P. Dekowski, K.K. Le, R.M. Dongaonkar, C.M. Quick. Texas A&M University. E581 860.12 Discoverable, Reproducible, and Reusable Biosimulation Models. D. Nickerson, P. Hunter. Auckland Bioengineering Institute and University of Auckland, New Zealand.
861. NEUROEXCITABILITY, NEUROTRANSMISSION AND NEUROPLASTICITY Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
(Sponsored by: APS Central Nervous System Section)
Presentation time: 12:45 pm–3:00 pm
Mon. 9:00 am—McCormick Place Convention Center, Hall F
E570 860.1 Utilization of Mechano-Biological Models to Predict Cell Adhesion Interactions Between Bone Marrow Endothelial Cells and Breast Cancer Cells. L. Irons, L. Xie, M. Owen, M.A. Hill, L.A. Martinez-Lemus, O. Glinski, V.V. Glinsky, R. O’Dea, B. Brook, G.A. Meininger. University of Nottingham, United Kingdom and University of Missouri. E571 860.2 Modeling Osmotic Transients During Exercise. K.M. Christmas, A. Jensen, J. Bassingthwaighte. University of Washington and Washington State University. E572 860.3 Numerical Determination of Wall Shear Stress in Red Blood Cell Membranes. P. Cabrales, V. Jani. UCSD. E573 860.4 Validation of Exposure-Response Modeling of Flow-Mediated Dilation as a Less Biased and More Informative Measure of Endothelial Function. K.M. Hallow, C.H. Van Brackle, R.A. Harris. University of Georgia, Augusta University and Ulster University, United Kingdom. E574 860.5 Mechanical Properties of Lymphangions That Optimize Stroke Work in a Lymphatic Network. S.A. Rohen, Y. Hamid, K.M. Ly, C.M. Quick. Texas A&M University. E575 860.6 Algebraic Formula Predicting Interstitial Fluid Pressure Homeostasis from the Interaction of Microvascular Filtration and Lymphatic Transport. S.Q. Hasnain, M.S. Villanueva, A.Q. Harris, C.A. Newman, M.C. Conley, T.B. Nguyen, C.M. Quick. Texas A&M University. E576 860.7 Algebraic Formula Predicting the Fraction of Absorbed Fluid Transported by Mesenteric Lymphatic Vessels. A.A. Joglar, C.M. Johnson, L.M. Harris, R.M. Dongaonkar, C.M. Quick. Texas A&M University. E577 860.8 Novel Mammalian Similarity Principle Predicted from the Standard Minimal Closed-Loop Cardiovascular Model. E.M. Duhon, D.N. Morea, E.L. Rimes, M.D. Lee, T.B. Nealy, C.M. Quick. Texas A&M University. E578 860.9 Predicting Regression of a Ductus Arteriosus. J. Hussain, H.A. Ahmed, W.A. Grant, M.D. Hernandez, C.M. Quick, R.H. Stewart. Texas A&M University. E579 860.10 Integration of Biomechanics and Mechanobiology to Predict Chronic Ventricular Wall Stress, Thickness, and Contractility. W.W. Fuertes, S. Shao, H.S. Mohiuddin, H. Lee, F.A. Dalal, C.M. Quick, R.H. Stewart. Texas A&M University.
Presentation time: 12:45 pm–3:00 pm E582 861.1 Effect of Smoking on Hearing: Evidence from Auditory Evoked Potentials. A. Dixit, Y.R. Singh, P. Sharma. All India Institute of Medical Sciences and Jodhpur, India. E583 861.2 Rac1/Cdc42-Activation Enhances Expression of Total and Phosphorylated Cav-1 in Differentiated Human Neurons Derived from Induced Pluripotent Stem Cells (iPSCs). S. Wang, Z. Zhang, B. Illum, B. Head, P. Patel. UCSD, University of California San Diego. E584 861.3 Pseudomonas aeruginosa-Induced Pulmonary Endothelial Amyloid Proteins Impair Long-Term Plasticity. M.T. Lin, R. Balczon, K. Morrow, B.M. Wagener, J. Pittet, T. Stevens. University of South Alabama, Alabama College of Osteopathic Medicine and University of Alabama-Birmingham. E585 861.4 Differential Role of NaV Isoforms in the Induction vs Conduction of Action Potentials in Vagal Afferent Nerves. H. Sun, S. Meeker, R.A. Herbstsomer, M. Kollarik, B.J. Undem. Johns Hopkins University. E586 861.5 Effects of Chronic Ethanol Exposure and Withdrawal on Glutamatergic Signaling at Two Afferent Projections Into the Rat Lateral/Basolateral Amygdala. M.M. McGinnis, M. Morales, N.J. Alexander, B.A. McCool. Wake Forest School of Medicine. E587 861.6 Activation of N-Methyl-D-Aspartate Receptor Inhibits Enkephalinergic Neurons in Mouse Spinal Superficial Dorsal Horn. E. Kato, Y. Takemura, T. Fukushima, Y. Hori. Dokkyo Medical University, Japan. E588 861.7 Effect of Hydrogen Peroxide and Glutamate on Muscle Spindle Afferent Receptor Ending Sensitivity to Muscle Stretch in Adult Mice. K. Than, A. Kwon, K.A. Wilkinson. San Jose State University. E589 861.8 Long Term Potentiation (LTP) in Syrian Hamster Hippocampal Slices Can Be Generated at Warm (35°C–20°C) but Not Cool (15°C) Slice Temperatures over a Hibernation Cycle. J.M. Horowitz, J.S. Hamilton, S.M. Chau, B.A. Horwitz. University of California Davis. E590 861.9 GABA and Glycine Are Co-Released Into Dorsal Motor Nucleus of the Vagus Neurons Following a Perinatal High Fat Diet. C.E. Clyburn, K.N. Browning. Penn State Hershey.
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PHYSIOLOGY MONDAY E591 861.10 Corticotropin-Releasing Hormone Regulates Spontaneous Excitatory Postsynaptic Currents on the Nucleus of the Solitary Tract. S. Jia, S. Mifflin. UNTHSC. E592 861.11 Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla (RVM) in Inflammatory Pain. M. Li, K.L. Suchland, S.L. Ingram. OHSU. E593 861.12 Effects of Chronic Exposure to THIP on Brainstem Neuronal Excitability in a Female Mouse Model of Rett Syndrome. W. Zhong, C.M. Johnson, N. Cui, H. Xing, Y. Wu, H.M. Mo, C. Jiang. Georgia State University. E594 861.13 Impact of Decentralization on Cholinergic Neurotransmission in Neurons of Mouse Major Pelvic Ganglia. C. Kyi, V. Garcia, D.J. Schulz. University of Missouri. E595 861.14 Low- and High-Frequency Field Potentials in Cortical Networks Exhibit Distinct Responses to Chemicals. C.M. Mack, D.R. Hall, D.W. Herr, T.J. Shafer. US Environmental Protection Agency and Columbia University. E596 861.15 In Vitro Synapse Development in the Cultured Neuronal Network Formed from Dissociated Chick Forebrain Neurons. S. Kuang, B.Z. Gao. Oakland University William Beaumont School of Medicine and Clemson University.
862. AUTONOMIC BALANCE: SYMPATHETIC AND PARASYMPATHETIC Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E597 862.1 Sex and Age Differences in Cardiac Autonomic Nervous Regulation in Response to Recumbent Positions. K. Sasaki, S. Bao, H. Sato, Y. Saiki, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E598 862.2 Does Mozart’s Music Have a Relaxation Effect? J. Hoshi, M. Sasaki, M. Sugawara, H. Yang, S. Bao, H. Tannno, E. Kanno, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E599 862.3 Autonomic Dysfunction Precede Hemodynamic and Metabolic Changes in an Experimental Model of Hypertension Submitted to Fructose Overload. C.d. Santos, N. Bernardes, D.D. Dias, F.F. Conti, F. Santos, K. Angelis. Federal University of São Paulo, Brazil, Universidade Nove De Julho, Brazil and College of Medical Sciences of Holy House of Mercy of Sao Paulo, Brazil. E600 862.4 ACE Gene Titration Modulates Acute Myocardial Infarction-Induced Autonomic and Functional Changes in Mice. O.A. Moraes. USP/InCor, Brazil. E601 862.5 Overweight Is Associated with Exacerbated Impairment on Heart Rate Variability in Offspring of Hypertensive Parents. A. Viana, M. Nascimento, J. de Paiva, F. dos Santos, F.M. Consolim-Colombo, M. Irigoyen, K. De Angelis. Universidade Nove de Julho—UNINOVE, Brazil, Heart Institute (InCor) and Medical School of University of Sao Paulo, Brazil. E602 862.6 The Effect of Transcranial Magnetic Stimulation on the Autonomic Nervous System in Pediatric Stroke. D. Chantigian, T. Rich, C. Chen, M. Lixandrao, B. Gillick, M. Keller-Ross. University of Minnesota—Twin Cities.
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863. SYMPATHETIC AND PARASYMPATHETIC REGULATION IN DISEASE Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F1 863.1 ESRD Patients Have Altered Pattern of Heart Rate Variability Responses to Graded Lower Body Negative Pressure. K. Ye, R. Downey, P. Liao, J. Park. Emory University and Atlanta VA Medical Center. F2 863.2 Neuromuscular Signaling in Myasthenia Gravis [MG] Patients. F.L. Sainvil, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. F3 863.3 Autonomic Dysregulation in Adolescent Concussion: Characterization and Temporal Resolution of Neurological Outcomes. C.S. Balestrini, M.E. Moir, K.C. Abbott, M. Johnson, L.K. Fischer, D.D. Fraser, J.K. Shoemaker. Western University, Canada and Children’s Health Research Institute, Canada. F4 863.4 “Taming the Flame” in Autoimmune Arthritis: Reining in Sympathetic Nerve Activity Improves Disease Outcome and Shifts Pro/Anti-Inflammatory Cytokine Balance Uniquely in Relevant Immune Organs. D.L. Bellinger, C.L. Lubahn, D. Lorton. Loma Linda University School of Medicine, Banner Sun Health Institute and Kent State University. F5 863.5 Beta2-Adrenergic Receptor Regulates Inflammation in Autoimmune Arthritis: Inhibit or Promote?— Depends on Timing, Immune Organ and Posttranslational Receptor Modifications. D. Lorton, C.L. Lubahn, C. Molinaro, D.L. Bellinger. Kent State University, Banner Sun Health Institute and Loma Linda University School of Medicine. F6 863.6 L-Arginine Infusion Reduces Muscle Sympathetic Nerve Activity and Blood Pressure in Patients with Chronic Kidney Disease. J. Kaur, J.R. Vranish, P.J. Fadel. University of Texas at Arlington.
864. CENTRAL REGULATION OF AUTONOMIC CONTROL: BRAIN STEM Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F7 864.1 Do Trigeminal Nerves That Innervate the Nose and External Nares Project to Medullary Dorsal Horn Locations Activated During Voluntary Diving in Rats? P. McCulloch, B. Del Prete, K. Lahrman, E. Warren, K. Di Novo. Midwestern University. F8 864.2 Presence of an Inhibitory Glycinergic Current in Dorsal Motor Nucleus of the Vagus Neurons Regulating Gastric Functions in Offspring of Maternal High Fat Diet Rats. C. McMenamin, R. Travagli, K. Browning. Penn State College of Medicine.
MONDAY PHYSIOLOGY F9 864.3 Second Hand Smoke Exposure Depresses Excitability and SK Channel Function of Cardiac Vagal Neurons in the Nucleus Ambiguus. J. Sun, E. Karey, S. Pan, Y. Chen, K.E. Pinkerton, C. Chen. University of California, Davis.
865. CENTRAL REGULATION OF AUTONOMIC CONTROL: CNS Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F10 865.1 Optogenetic Stimulation of PVN-RVLM Neurons Increases Sympathetic Nerve Activity in Anesthetized Rats. S. Koba, E. Hanai, N. Kumada, N. Kataoka, K. Nakamura, T. Watanabe. Tottori University Faculty of Medicine, Japan, Nagoya University Graduate School of Medicine, Japan, PRESTO and JST, Japan. F11 865.2 Spinal Cord Stimulation Reduces Ventricular Arrhythmogenicity During Ischemia. E.A. Dale, K. HowardQuijano, T. Takamiya, Y. Kubo, J.P. Kipke, A. Mahajan. UCLADavid Geffen School of Medicine. F12 865.3 Effect of Sedentary Conditions on the Expression of GABAAα2 Receptor Subunits in Bulbospinal C1 and Non-C1 Neurons Along the Rostrocaudal Extent of Rat Rostral Ventrolateral Medulla (RVLM). B.E. Fyk-Kolodziej, T.A. Azar, I.J. Llewellyn-Smith, P.J. Mueller. Wayne State University and Flinders University, Australia. F13 865.4 Hippocampal CA1 Neuronal and Sympathetic Nerve Activity in Response to Repeated Fear Conditioning in Rats. H. Ukita, M. Yoshimoto, K. Nagao, K. Miki. F14 865.5 Sympathetic and Phrenic Nerve Activities in the Offspring of High Fat Diet Feeding Dams. N.O. Amaral, M. Bassi, J.M. Sa, R.M. Barbosa, D. Zoccal, J. Menani, E. Colombari, G. Pedrino, D.S. Colombari. Centre for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás, Brazil, São Paulo State University (UNESP) and School of Dentistry, Brazil. F15 865.6 Does Temporary Inhibition of the Human Primary Motor Cortex Alter Resting and Isometric Handgrip Exercise-Mediated Sympathetic Neural Responses? D.S. Kimmerly, S. Boe, M. Ladouceur, J.A. Weir. Dalhousie University, Canada.
866. CENTRAL REGULATION OF AUTONOMIC CONTROL: HYPOTHALAMUS Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F16 866.1 Glutamatergic Neurons in the Dorsal Hypothalamic Area Dissociate Thermogenesis from Heat Conserving Pathways During Stress Responses. N.L. Machado, S. Abbott, P. Fuller, M. Fontes, C. Saper. Beth Israel Deaconess Medical Center—Harvard Medical School, Heart Research Institute, Sydney and Federal University of Minas Gerais, Brazil. F17 866.2 Post-Traumatic Stress Sensitizes the Angiotensin II-Elicited Hypertensive Response. B. Xue, Y. Yu, S. Wei, T.G. Beltz, F. Guo, R.B. Felder, A.K. Johnson. University of Iowa. F18 866.3 Arcuate NPY/AgRP Neurons Decrease Arterial Pressure and Sympathetic Nerve Activity in Part via a Projection to the Dorsomedial Hypothalamus in Mice. Z. Shi, C.J. Madden, V.L. Brooks. Oregon Health & Science University. F19 866.4 Effects of L-Arginine Supplementation on the Tissue Production of Nitric Oxide and Cardiovascular Modulation by the Paraventricular Nucleus of Hypothalamus. H.d. Raquel, N.Z. Ferreira, B.F. Lucchetti, P. Pinge-Filho, M. Martins-Pinge. State University of Londrina, Brazil. F20 866.5 Postnatal Developmental Changes of Orexin in Spontaneously Hypertensive Rats. S. Dunn, A. Moushey, R. Dong, A. Li. Geisel School of Medicine at Dartmouth College. F21 866.6 AT1aR Dependent GABAa Inhibition in the MnPO. G.E. Farmer, J.T. Little, M.E. Bachelor, J.T. Cunningham. UNT Health Science Center. F22 866.7 Increased BDNF Expression in the Paraventricular Nucleus of the Hypothalamus (PVN) Abolishes Hypotensive Actions of Nucleus of the Solitary Tract (NTS) Catecholaminergic Neurons. B. Erdos, N.C. Cruickshank, Z.D. Einwag, C.L. Schaich, T.L. Wellman. University of Vermont. F23 866.8 DREADD-Induced cFos Expression in the Basal Forebrain of Male Rats. A.B. Marciante, J. Cunningham. University of North Texas Health Science Center. F24 866.9 Identification of Stress-Activated Inputs to the Dorsomedial Hypothalamus. L. Prestipino, E.A. Ouro, S.K. Jayaratne, J.W. Polson. The University of Sydney, Australia.
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867. CHEMOREFLEX FUNCTION AND AUTONOMIC REGULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F25 867.1 The Impact of Nitrate Supplementation on the Peripheral Chemoreceptor Reflex to Hypoxia in Older Adults. J. Bock, J. Limberg, W. Hughes, N. Kruse, K. Ueda, D. Casey. University of Iowa and Mayo Clinic. F26 867.2 Role of Carotid Body to Hypertension and Pulmonar Ventilation in Renovascular Hypertensive Rats. M.R. Melo, S. Gasparini, G.F. Speretta, E.F. da Silva, G.R. Pedrino, J.V. Menani, D.B. Zoccal, D.S. Colombari, E. Colombari. School of Dentistry, UNESP, Brazil and UFG, Brazil. F27 867.3 Peripheral Chemoreflex Regulates PostExercise Cardiac Vagal Reactivation in Healthy Humans and Patients with Pulmonary Arterial Hypertension. M. PaulaRibeiro, I.C. Ribeiro, L. Aranda, T.M. Silva, C.M. Costa, R.P. Ramos, J.O. Arakaki, S.L. Cravo, L.E. Nery, M.K. Stickland, B.M. Silva. Federal University of Sao Paulo, Brazil and University of Alberta, Canada. F28 867.4 Low-Dose Dopamine, but Not Acute Hyperoxia, Attenuates the Sympathoexcitatory Response to Hyperinsulinemia in Healthy Humans. J.K. Limberg, M.T. Mozer, W.W. Holbein, B.D. Johnson, N.R. Prabhakar, T.B. Curry, M.J. Joyner. Mayo Clinic, University at Buffalo and University of Chicago. F29 867.5 Ventilation Inhibits Sympathetic Neural Recruitment During Severe Chemoreflex Stress. M.B. Badrov, O.F. Barak, T. Mijacika, I. Drvis, Z. Dujic, J. Shoemaker. Western University, Canada, University of Split School of Medicine, Croatia, University of Novi Sad, Yugoslavia and University of Zagreb, Croatia. F30 867.6 Role of Alpha-Adrenergic Inputs to PVN in the Cardiovascular Responses to Acute Hypoxia. I. Beig, S. Mifflin. UNTHSC. F31 867.7 Blood Pressure Responses to Acute Peripheral Chemoreceptor Activation Are Augmented During Head Out Water Immersion. J.R. Sackett, Z.J. Schlader, S. Sarker, C.L. Chapman, B.D. Johnson. University at Buffalo. F32 867.8 Expression of Adrenergic Alpha 1 Receptor Subtypes in Magnocellular, Pre-Autonomic and Medial Parvocellular Regions of the Paraventricular Nucleus of the Hypothalamus (PVN): Effects of Acute Intermittent Hypoxia. C.M. Heesch, K.M. Coldren, S. Barr. University of Missouri. F33 867.9 PVN Neuropeptide Neurons May Modulate nTS Activation and Cardiorespiratory Responses to Peripheral Chemoreflex Stimulation. B.C. Ruyle, C.M. Heesch, E.M. Hasser. University of Missouri. F34 867.10 Acute Intermittent Hypoxia (AIH) and Continuous Hypoxia Increase Augmented Breaths and Efferent Splanchnic Sympathetic Nerve Activity in Conscious Rats. K.M. Coldren, E. Hasser, C. Heesch. University of Missouri.
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868. CIRCUMVENTRICULAR ORGANS: A BLOODBRAIN INTERFACE FOR MODULATION OF CARDIOVASCULAR AND IMMUNE FUNCTION AND FLUID AND ELECTROLYTE BALANCE (POSTERS) Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F35 868.1 Tumor Necrosis Factor Alpha Increases Excitability in Subfornical Organ Neurons. N.J. Simpson, A.V. Ferguson. Queen’s University, Canada. F36 868.2 Baroreflex Activation Reduces Central Inflammation Induced by Lipopolysaccharide in Conscious Rats. F. Brognara, J.A. Castania, A.H. Lopes, D.P. Dias, T.M. Cunha, F.Q. Cunha, R. Fazan Jr., L. Ulloa, A. Kanashiro, H.C. Salgado. Ribeirão Preto Medical School, Brazil and New Jersey Medical School. F37 868.3 Deletion of Secreted Form of Prorenin in the Subfornical Organ Attenuates the Development of DOCA-Salt Induced Hypertension. C.J. Worker, S.A. Buller, D. Jensen, C.D. Sigmund, Y. Feng. University of Nevada, Reno, School of Medicine, Roy J. and Lucille A. Carver College of Medicine and University of Iowa. F38 868.4 Role of the OVLT in the Development of DOCASalt Hypertension. J.P. Collister, D.B. Nahey, C.T. Banek, J.W. Osborn. University of Minnesota. F39 868.5 Blockade of Brain Sodium Channels or Electroneutral Transporters Attenuates the Hypertensive Response to Central NaCl Stimulation. J.L. King, B.J. Kinsman, S.D. Stocker. University of Pittsburgh. F40 868.6 The Effect of Sodium Depletion with or Without Concomitant Dehydration on Fos Immunoreactivity in the Different Subregions of the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis of the Rat. M.J. McKinley, M. Goga. Florey Institute of Neuroscience and Mental Health, Australia.
869. CENTRAL NERVOUS SYSTEM: OTHER Poster (Sponsored by: APS Central Nervous System Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F41 869.1 The Effects of Imidacloprid on Danio rerio (Zebrafish) Ocular and Osteological Development. H. Babcock, K. Cochran, M.A. Daggett. Missouri Western State University. F42 869.2 Brain Region Specific Association of Microtubule-Associated Protein 2 with Inflammatory and Growth Factor Gene Expression. J. Maxi, S. Oberhelman, D.E. Mercante, G.J. Bagby, S. Nelson, P. Molina. Louisiana State University Health Sciences Center.
MONDAY PHYSIOLOGY F43 869.3 Highly Palatable Food During Adolescence and Youth Increased Anxiety-/Depression-Like Behaviors in Males, but Not in Females. J. Jahng, J. Kim, J. Lee. Seoul National University School of Denistry, Republic of Korea. F44 869.4 The Role of the Vestibular Nucleus in the Multimodal Coordination of Balance. S.R. Wittman, D.M. Miller, B.J. Yates, A.A. McCall. University of Pittsburgh. F45 869.5 For Patients with Chronic Musculoskeletal Pain, Does Therapeutic Neuroscience Education (TNE) Complement Exercise And/or Manual Treatment in Decreasing the Perception of Pain? J. Gamper, A. Bryant, J. McCallum, S. Wilson, D. Lehman. Tennessee State University. F46 869.6 Characteristic Changeable Shape of the Otolith Organs in Meniere’s Disease. H. Tanioka. Tanioka Clinic, Japan. F47 869.7 Transient Receptor Potential Ankyrin 1 Channel in Regulating Emotion, Learning and Memory, Cognition, and Social Behavior of Mice. H. Lee, K. Lee, H. Lin, T. Lee. Institute of Anatomy and Cell Biology, National Yang-Ming University, Taiwan, Department of Physiology and National Yang-Ming University, Taiwan. F48 869.8 Dietary Serine Prevents Synergistic Action of Paraquat and Lectins in the Development of ParkinsonianLike Gastric Dysmotility. L. Anselmi, C. Bove, J. Hampton, R. Travagli. Penn State College of Medicine and Dickinson College. F49 869.9 Dietary Serine Prevents the Parkinsonian-Like Dysfunctions Induced by Subthreshold Doses of Paraquat and Lectin. C. Bove, L. Anselmi, R. Travagli. Penn State College of Medicine. F50 869.10 Alterations of a Nigro-Vagal Pathway in a Rodent Model of Parkinson’s Disease. J. Hampton, L. Anselmi, R. Travagli. Dickinson College and Penn State College of Medicine. F51 869.11 Effect of Monoamine Reuptake Inhibitors on Seizures in DBA/1 Mice. H.A. Ahamed, Y. Kim, E. Bravo, G.B. Richerson. University of Iowa. F52 869.12 Differential Expression of VEGF Isoforms and Receptors in the Phrenic Motor Nucleus of End-Stage SOD1G93A Mutant Rats. I. Satriotomo, G.S. Mitchell. McKnight Brain Institute and University of Florida.
870. ALVEOLAR EPITHELIAL CELL BIOLOGY Poster (Sponsored by: APS Respiration Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F53 870.1 Compartment-Specific Effects of Alveolar Heparan Suflate Shedding After Intratracheal Lipopolysaccharide. S. Haeger, Y. Yang, J. Ford, F. Zhang, M. Suflita, A. Dedent, R. Zemans, R. Tuder, E. Schmidt. University of Colorado at Denver, Rensselaer Polytechnic Institute and National Jewish Health. F54 870.2 Vimentin Regulates Activation of the NLRC4 Inflammasome. Y. Cheng, J. Davis, Z. Lu, K. Gates, B. Coates, K. Ridge. Northwestern University. F55 870.3 Vimentin Directly Interacts with NLRP3 and Regulates Inflammation. D. Shumaker, K. Ridge. Northwestern University.
F56 870.4 TRPV4 and Ca2+ Downregulate ENaC Expression and Activity Following a Loss of Barrier Integrity in Alveolar Epithelial Cells. A. Dagenais, J. Desjardins, W. Shabbir, Y. Berthiaume. Institut de Recherches Cliniques de Montreal, Canada and University of Vienna, Austria. F57 870.5 Cell-Free Hemoglobin Increases Lung Alveolar-Capillary Barrier Permeability via TLR4. C.M. Shaver, N.D. Putz, J.A. Bastarache, L.B. Ware. Vanderbilt University Medical Center.
871. EPIGENETICS AND THE LUNG Poster (Sponsored by: APS Respiration Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F58 871.1 AAV9-miR-29b Treatment Decreases Expression of Matrix Proteins and Improves Alveolarization in Mice Exposed to Maternal Inflammation and Neonatal Hyperoxia. K.M. Heyob, C.A. Pool, T.E. Tipple, L.K. Rogers. The Research Institute at Nationwide Children’s Hospital, University of Alabama, Birmingham and The Ohio State University. F59 871.2 Liposomal miR-29b Delivery Attenuates Increased Expression of Matrix Proteins and Improves Alveolarization in Mice Exposed to Maternal Inflammation and Neonatal Hyperoxia. S.S. Sugar, K.M. Heyob, T.E. Tipple, L.K. Rogers. The Research Institute at Nationwide Children’s Hospital, University of Alabama, Birmingham and The Ohio State University. F60 871.3 Long-Living Alveolar Macrophages Modulate Severity of Lung Injury and Postnatal Lung Development in Hyperoxia-Induced Lung Injury Mouse Model. A. Misharin, A.C. McQuattie-Pimentel, C. Chen, P.A. Reyfman, K.R. Anekalla, J. Taylor, H.J. Cardona, K. Williams, N. Joshi, G. Budinger, K. Mestan, K. Farrow. Northwestern University. F61 871.4 NADPH-Oxidase Signaling Is Dysregulated in Thromboxane Analog-Induced Intrauterine Growth Restricted Mice Versus Appropriately Grown Mice. M.E. Robbins, H.J. Cardona, J.M. Taylor, M. Perez, C. Fung, K.N. Farrow. Northwestern University and University of Utah. F62 871.5 Epigenetic Regulation of Macrophage Linage During Acute Lung Injury and Resolution. I. Rochford, J.C. Joshi, D. Mehta. University of Illinois at Chicago.
872. LUNG DEVELOPMENT AND PLASTICITY Poster (Sponsored by: APS Respiration Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F63 872.1 Identification of a SOX2/SOX9 Double Positive Cells Progenitor Cell Population Required for Branching Morphogenesis in Human Lung. S. Danopoulos, S. Bellusci, D. Warburton, D. Al Alam. Children’s Hospital Los Angeles.
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PHYSIOLOGY MONDAY F64 872.2 Maternal High Fat Diet Causes Decreased Alveolarization and Persistent Pulmonary Inflammation in the Offspring. K.M. Heyob, A.J. Trask, M. Thompson, L.K. Rogers. The Research Institute at Nationwide Children’s Hospital and The Ohio State University. F65 872.3 Increased Activation of M2 Macrophages in 1 Year-Old Rat Lungs Following Neonatal Hyperoxia Exposure. H.E. Yoder, R.K. Braun, A. Sobotik, L.H. Tetri, K.N. Goss, M.W. Eldridge. UW-Madison. F66 872.4 The Effect of in Vivo High Molecular Weight Hyaluronan Treatment on Airway Reactivity in a Neonatal Mouse Model of Continuous Positive Airway Pressure (CPAP). C. Mayer, P. MacFarlane. Case Western Reserve University. F67 872.5 Postnatal Growth Restriction Alters Lung Function and Structure in Juvenile Rats. C.R. Ballard, J. Zhou, K. Zuspan, A. Rebentisch, H. Wang, L. Joss-Moore. Colby College and University of Utah.
873. RESPIRATORY MOTOR NEURONS AND MUSCLES Poster (Sponsored by: APS Respiration Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F68 873.1 Diaphragm and Intercostal Muscle Activity Following Unilateral Mid-Cervical Spinal Cord Contusion in the Rat. M. Wen, K. Lee. National Sun Yat-sen University, Taiwan. F69 873.2 Aberrant Respiratory Control in the Mdx Mouse Model of Duchenne Muscular Dystrophy. D.P. Burns, E. Lucking, A. Roy, K. Murphy, F.B. McDonald, R. Wilson, D. Edge, K.D. O’Halloran. University College Cork, Ireland, University of Calgary, Canada and Trinity College Dublin, Ireland. F70 873.3 Motoneuron Endocytosis and Intracellular Trafficking of Cholera Toxin B Modified Protocells. M.A. Gonzalez Porras, P. Durfee, J. Brinker, G. Sieck, C.B. Mantilla. Mayo Clinic Graduate School, University of New Mexico and Mayo Clinic. F71 873.4 Endo-Lysosomal Escape of Cholera Toxin B-Modified Protocells in Motoneurons. S. Giambini, M.A. Gonzalez Porras, J. Brinker, G. Sieck, C.B. Mantilla. Mayo Clinic Graduate School, University of New Mexico and Mayo Clinic. F72 873.5 Hyperbaric Oxygen Treatment Following MidCervical Spinal Contusion Injury—Diaphragm Outcomes. S.M. Turner, C.M. Schuster, A.B. Morton, J. Hinkley, D.D. Fuller, A.J. Smuder. University of Florida. F73 873.6 Altered Neuromuscular Junction Protein Expression in the Diaphragm of Mechanically Ventilated Patients. A.J. Smuder, S. Levine, S.K. Powers. University of Florida and University of Pennsylvania. F74 873.7 Spinal Cord Injury Leads to Reductions in Central Nervous System 5HT Coupled with Blunting of Arousal and Genioglossus Muscle Responses to Hypercapnia in Mice. D. Komnenov, D. Kuhn, J. Mateika. Wayne State University School of Medicine and John D. Dingell VA Medical Center. F75 873.8 Contribution of Expiratory Abdominal Muscle Recruitment in the Perinatal Period Across Sleep Wake Cycles. J. Saini, S. Pagliardini. University of Alberta, Canada.
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F76 873.9 Sex Differences and Proteomic Profiling of Diaphragm Weakness in Chronic Heart Failure. R.C. Kelley, B. McDonagh, S. Hanna, L.F. Ferreira. University of Florida and University of Liverpool, United Kingdom. F77 873.10 Comparison of Treatment Efficacy in the Hypoglossal Motor System of AAV-DES-coGAA and Novel Vector AAV-DES-IGFIIcoGAA in Gaa-/- Mice. B.M. Doyle, S.M. Turner, A. Poirier, M.L. Jorgensen, D.J. Falk, P.A. Doerfler, B.J. Byrne, D.D. Fuller. University of Florida. F78 873.11 State-Dependent Expiratory Abdominal Activity During Hypercapnia in Adult Unanaesthetized Rats. I.P. Leirao, C.A. Silva Jr, L.H. Gargaglioni, G.S. da Silva. Sao Paulo State University UNESP-FCAV, Brazil. F79 873.12 Differential Expression of Serotonin 2A (5HT2A) Receptors in the Phrenic Motor Nucleus Over Disease Progression in a Rat Model (SOD1G93A) of ALS. L.F. Borkowski, T.A. Craig, N.L. Nichols. University of Missouri and Columbia. F80 873.13 Phrenic Motor Neuron Survival Caudal to C2 Hemisection. L.L. Allen, J.V. Santiago, Z.A. Asa, A.E. Holland, M. Ciesla, I.S. Satriotomo, G.S. Mitchell, E.J. Gonzalez-Rothi. University of Florida. F81 873.14 Adenosine 2A (A2A) Receptor Expression in Rats with Motor Neuron Death from Intrapleural CTB-Saporin Injections. T.A. Craig, S.M. Brown, N.L. Nichols. University of Missouri-Columbia. F82 873.15 Aging-Related Changes in Motoneuron Autophagy. H.M. Gransee, M.A. Gonzalez, G.C. Sieck, C.B. Mantilla. Mayo Clinic. F83 873.16 Effects of C2 Chronic Hemisection on Inspired Volume Generation During High Frequency Spinal Cord Stimulation (HF-SCS). K.E. Kowalski, T.E. Dick, A.F. DiMarco, W.J. Alilain. MetroHealth Medical Center, Case Western Reserve University, VA Medical Center, Case Western Reserve University, MetroHealth Medical Center, Case Western Reserve University and University of Kentucky. F84 873.17 Targeting IL-6 and CRFR2 Improves Diaphragm Muscle Function and Restores Ventilation in Mdx Mice. D.P. Burns, L. Canavan, J. Rowland, R. O’Flaherty, D. O’Malley, D. Edge, K.D. O’Halloran. University College Cork, Ireland and Trinity College Dublin, Ireland. F85 873.18 Functional Specializations of Hypoglossal Motoneurons Innervating Intrinsic and Extrinsic Tongue Muscles. J.C. Wealing, M. Cholanian, R. Fregosi. University of Arizona. F86 873.19 Reorganization of Respiratory Motor Control Following Unilateral Diaphragm Paralysis. O.U. Khurram, G.C. Sieck, C.B. Mantilla. Mayo Clinic. F87 873.20 Descending Premotor Inputs to Phrenic Motoneurons Across Motor Behaviors in Anesthetized and Awake Rats. F. Jimenez-Ruiz, C.B. Mantilla, O.U. Khurram, S. Rana, W. Zhan, H.M. Gransee, G.C. Sieck. Mayo Clinic. F88 873.21 Respiratory Motor Deficit in Children with Spinal Cord Injury. G. Singh, S. Trimble, S. Aslan, A. Behrman, A. Ovechkin. University of Louisville. F89 873.22 Aging-Related Deficits in Neuromuscular Transmission and Force Loss in the Diaphragm Muscle. C.B. Mantilla, H.M. Gransee, S.M. Greising, G.C. Sieck. Mayo Clinic and U.S. Army Institute of Surgical Research. F90 873.23 Aging-Associated Abnormalities of Diaphragm Contractile Function in Wistar-Kyoto Rats. N.M. Novielli, A.J. Foster, J.S. Huber, C.L. Murrant, J.A. Simpson. The University of Guelph, Canada.
MONDAY PHYSIOLOGY
874. COMPARATIVE CARDIO RESPIRATORY TOPICS Poster
875. IMMUNE CELLS INVOLVED IN CARDIOVASCULAR DISEASE
(Sponsored by: APS Comparative and Evolutionary Physiology)
Poster
Mon. 9:00 am—McCormick Place Convention Center, Hall F
(Sponsored by: APS Cardiovascular Section)
Presentation time: 12:45 pm–3:00 pm F91 874.1 Perineuronal Net Expression in the Brain of an Obligate Hibernator. C. Schwartz, M. Bonner, A. Greife, M. Hammer, R. Johnson, A. Marchand, B. Morrow, L. Olson. University of Wisconsin-La Crosse. F92 874.2 Seasonal Metabotypes in Small Birds. B.W. Wone, J.M. Kinchen, D.L. Swanson. University of South Dakota and Metabolon. F93 874.3 Oxygen Consumption of Desert Pupfish at Ecologically Relevant Temperatures Suggests a Significant Role for Anaerobic Metabolism. S. Hillyard, F. van Breukelen. UNLV. F94 874.4 Examination of the Physiological Effects of Ethylene Glycol Exposure on Muscle and Liver Tissue of the Leopard Frog, Rana pipiens. A.N. Funk, E.K. Stabenau. Bradley University. F95 874.5 Mechanical and Chemical Factors Required for Maintaining Cardiac Rhythm in Drosophila melanogaster Larva. C. de Castro, J. Titlow, Z.R. Majeed, C. Malloy, K. King, R. Cooper. University of Chicago, University of Kentucky, University of Oxford, United Kingdom and University of Salahaddin, Iraq. F96 874.6 Characterization of the Receptors Associated with the Differing Responses to the Neuropeptide, AST-C, by the Cardiac Ganglion of the American Lobster, Homarus americanus. P. Walsh, S. Pong, M. Armstrong, A.E. Christie, P.S. Dickinson. Bowdoin College and University of Hawaii at Manoa. F97 874.7 Effects of Altering Activity of Sensory Systems, Motor Output, Skeletal Muscle and Neurons Containing ACH, Dopamine, 5-HT and GABA in Drosophila melanogaster. R.L. Cooper, C. Malloy, Z.R. Majeed; Z.R, J. Titlow, D.D. Mahmood, E. Somasundaram, A. Omar, C. Hermanns, J. Higgins, K. Hall. University of Kentucky, University of Salahaddin, Iraq, University of Oxford, United Kingdom and University of Kentucky. F98 874.8 Peptidergic Modulation in the Lobster Cardiac Neuromuscular System: A Transcriptomic Analysis of Peptides and Peptide Receptors in Cardiac Ganglion and Muscle. H. Gandler, M. Stanhope, D. Shea, A. Christie, A. Yu, T. LaMeyer, V. Roncalli, M. Cieslak, P. Dickinson. Bowdoin College and University of Hawaii at Manoa.
(Supported by Portland Press)
Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F99 875.1 Role of Dendritic Cell Serum/Glucocorticoid Regulated Kinase 1 in Hypertension. J.D. Foss, N.R. Barbaro, L. Xiao, D.G. Harrison, A. Kirabo. Vanderbilt University Medical Center. F100 875.2 IL-10 Improves Cardiac Remodeling PostMyocardial Infarction by Increasing M2 Macrophage Polarization to Improve Scar Formation. M. Jung, Y. Ma, A. Yabluchiansky, R.P. Iyer, K. DeLeon-Pennell, M.R. Garrett, M.L. Lindsey. University of Mississippi Medical Center and G.V. (Sonny) Montgomery Veterans Affairs Medical Center. F101 875.3 Human Osteopontin Isoforms Differentially Promote Post-Ischemic Neo-Vascularization via Divergent Effects on Macrophages in Vivo and in Vitro. G. Lee, C. Caroti, G. Joseph, D. Weiss, H. Salazar, W. Taylor, A. Lyle. Emory University. F102 875.4 Vasopressin Antagonists Regulate Immune Responses in Preeclampsia. S.M. Scroggins, D.A. Santillan, J.M. Peterson, K.J. Huber-Keener, J.A. Sandgren, K.J. Perschbacher, N.A. Pearson, E.J. Devor, D.T. Gomendoza, G.L. Pierce, J.L. Grobe, M.K. Santillan. University of Iowa. F103 875.5 Natural Killer Cells Stimulated in Response to Placental Ischemia Mediate Hypertension, Intrauterine Growth Restriction, and Inflammation During Pregnancy. D.C. Cornelius, M. McCalmon, L.M. Amaral, J. Elfarra, M.W. Cunningham; Jr., T. Ibrahim, J.D. Scott, B. LaMarca. University of Mississippi Medical Center. F104 875.6 Functional Status of Perilymphatic Mast Cells Is Critical for Lymphatic and Immune Functions. A.A. Gashev, G.F. Dusio, O.Y. Gasheva, H. Skoog, R. Tobin, C. Peddaboina, C. Meininger, M. Newell-Rogers, D.C. Zawieja, I. Tsoy Nizamutdinova. Texas A&M University HSC College of Medicine, Baylor Scott & White Health and Texas A&M University HSC. F105 875.7 Chronic Placental Ischemia Increases InnateLike Peritoneal B-1 B Cells in the Rat. J.F. Regal, E.J. Odean, C.R. Wing, J.A. Wilcox, J.S. Gilbert, S.D. Fleming. University of Minnesota Medical School, Duluth campus and Kansas State University. F106 875.8 Vasoprotective Actions of Chronic Vagal Nerve Stimulation in Hypertensive Rats—Role of Inflammatory Cytokines and Vascular Migration of Inflammatory Cells. H.M. Stauss, B.K. Tan, D.L. Rotella, J.A. Ratcliff, S.C. Harwani, M.W. Chapleau. The University of Iowa and Veterans Affairs Medical Center. F107 875.9 Low Phosphate Diet Prevents Klotho Deficiency-Induced Aortic Aneurysm. Q. Wang, Y. Lin, Q. Ali, Z. Sun. University of Oklahoma HSC. Receptor 9-Dependent F108 875.10 Toll-Like Phosphorylation of AMPKα Occurs via TAK1 and Inflammatory Signaling in Vascular Smooth Muscle Cells. C.G. McCarthy, C.F. Wenceslau, S. Ogbi, T. Szasz, R. Webb. Augusta University.
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PHYSIOLOGY MONDAY F109 875.11 Functional Evaluation of Prorrenin/renin Receptor in Immune Cells from Rats with Pregnancy-Induced Hypertension. E. Galicia-Galicia, L. Anguiano-Robledo, P. Lopez-Sanchez, M. Hernandez-Campos. Instituto Politecnico Nacional, Mexico.
876. APOPTOSIS, CELL STRESS AND CELL DEATH Poster (Sponsored by: APS Cell and Molecular Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F110 876.1 Suppression of DAPK1 Benefits to Ischemia Brain Injury via Mechanism(s) of ER Stress Mediated Apoptotic Pathway. J. Kim, J. Won, Y. Hong. Gyeongsang National University, Republic of Korea, Inje University, Republic of Korea. F111 876.2 LRP-1 Targeted Neuroprotection in a Mouse Model of Diabetic Retinopathy. D.H. El-Desoky, P. Bhattacharjee, A. Hossain. Xavier University of Louisiana. F112 876.3 Mapping the Apoptotic Process with Super Resolution Microscopy in Kidney Cells Challenged with High Glucose. K. Bernhem, L. Zhang, J. Fontana, L. Nilsson, L. Scott, H. Brismar, A. Aperia. KTH, Royal Institute of Technology, Sweden and Karolinska Institutet, Sweden. F113 876.4 Culture Medium Fatty Acid Withdrawal Prompts Insulin-Producing Cell Death. M.P. Rosim, V.A. Nunes, S. Lensen, R. Curi, A.K. Azevedo-Martins. Universidade de São Paulo, Brazil and Medizinischen Hochschule Hannover, Germany. F114 876.5 Effect of PPAR Partial Agonist, GQ-16, on Viability of Breast Cancer Cells in Culture. A.B. Ferreira, M.S. Coelho, A. Amato, F.R. Neves, I.C. Rodrigues, C. Royer. Faculty of Health Sciences, University of Brasilia, Brazil, Faculty of Ceilândia and University of Brasilia, Brazil. F115 876.6 Vanadium Complex Induced Cancer Cell Death via RIPK3 Activated Necroptosis. S.R. Rana, V. McCaffrey, B.J. Rabquer. Albion College. F116 876.7 Involvement of NF2 Signaling Pathway in β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis. S. Dalal, B.A. Connelly, M. Singh, K. Singh. East Tennessee State University and James H. Quillen VA Medical Center.
877. STEM CELLS, CELL GROWTH, DEVELOPMENT, DIFFERENTIATION, AND AUTOPHAGY Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F117 877.1 Comparison of Growth Supplements on the Differentiation of Adipose Derived Stem Cells from Burned and Non-Burned Human Skin. L.H. Mangum, N. Wrice, D. Larson, S. Natesan, R. Christy. USAISR.
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F118 877.2 The Effects of High Fat Diet-Induced Obesity and Exercise Training on Hematopoietic Stem and Progenitor Cells Following Sub-Lethal Radiation. R. Emmons, D. Hernández-Saavedra, Z.S. Parks, H. Chen, M. De Lisio. University of Illinois at Urbana-Champaign and University of Ottawa, Canada. F119 877.3 Circulating Progenitor Cell Quantity and Colony-Forming Capacity in Lean and Obese Adults. G.M. Niemiro, J.M. Allen, L.J. Mailing, H.D. Holscher, J.A. Woods, M. De Lisio. University of Illinois at Urbana-Champaign and University of Ottawa, Canada. F120 877.4 Xenotransplantation of Human Mesenchymal Stem Cells Alters Host Gene Expression Following Prolonged High Fat Feeding. C. Newell, D.S. Hittel, V. Nyamandi, A. Khan, J. Shearer. Cumming School of Medicine, University of Calgary, Canada and University of Calgary, Canada. F121 877.5 Palmitic Acid Methyl Ester Regulates Proliferation of Human Mesenchymal Stem Cells. J-H. Lin, K-T. Yang. Tzu Chi University, Taiwan. F122 877.6 Effect of Hypoxia and Heat Inactivated Serum on Mesenchymal Stem Cell Migration. R.A. Boomsma, V.K. Jochems, A.R. Spotts. Trinity Christian College. F123 877.7 Mouse Prostate Organoids as a Model for Prostate Cancer. J.A. Foley, K. Shah, N.A. Bradbury. Chicago Medical School and National Institutes of Health. F124 877.8 Modeling Ion Channel Function with Murine Intestinal 3D Stem Cell Cultures. J.A. Sowick, K. Shah, N.A. Bradbury. Chicago Medical School and National Institutes of Health. F125 877.9 Developing Renal Organoids Using Human Embryonic Stem Cells. B.J. Torres Collazo, C. CebrianLigero. University of Puerto Rico at Ponce, Puerto Rico and University of Michigan Medical School. F126 877.10 Intravenous Delivery of Cardiosphere-Derived Cells Improves Striated Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy. R.G. Rogers, M.A. Aminzadeh, M. Fournier, K. Gouin, L. Sanchez, L. Li, C. Sakoda, E. Marban. Cedars-Sinai Medical Center and Capricor Therapeutics. F127 877.11 Effect of Fatty Acids on Myogenesis and Mitochondrial Biosynthesis During Murine Skeletal Muscle Cell Differentiation. T. Hsueh, X. Wang, J.I. Baum, Y. Huang. University of Arkansas. F128 877.12 Sirtuin 1 Regulation of Mitophagy and Function in Hindlimb Muscles of Aging Mice. M.J. Myers, J.S. Mohamed, S.E. Alway. West Virginia University School of Medicine. F129 877.13 The Role of Sirtuin 2 in the Regulation of Myogenesis. D.A. Stanton, S.E. Alway, J.S. Mohamed. West Virginia University School of Medicine. F130 877.14 The Role of CIP4 in SH-SY5Y Cell Proliferation and Differentiation. P. Suthivanich, W. Saengsawang. Faculty of Science and Mahidol University, Thailand.
MONDAY PHYSIOLOGY
878. GI AND LIVER STEM CELLS Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F131 878.1 Obesity, Independent of the Type of Diet, Drives Lasting Effects on Intestinal Epithelial Stem Cell Proliferation. W. Zhou, K. Blackmore, M. Feldner, M.J. Dailey. University of Illinois at Urbana-Champaign. F132 878.2 Sex Differences in Intestinal Epithelial Crypt Cell Proliferation. W. Zhou, N. Suriyavirun, M.J. Dailey. University of Illinois at Urbana-Champaign. F133 878.3 A Potential Role of Neuroendocrine Tumor Gene MEN1 in Reserve Intestinal Stem Cell (rISC) Proliferation. K.P. McGowan, L. Samsa, E. Soto, H. Lara, S.T. Magness. University of North Carolina at Chapel Hill. F134 878.4 Epimorphin Regulates the Mouse Intestinal Stem Cell Niche via the Stromal Microenvironment. C.C. Vishy, E.C. Swietlicki, G.C. Heslop, L.C. Lyons, M.S. Levin, D.C. Rubin. Washington University School of Medicine and VA St. Louis Health Care System. F135 878.5 Notch and mTORC1 Regulate Growth of Human Gastric Cancer Cells and Human Gastric Organoids. G. Wong, E.S. Demitrack, L.C. Samuelson. University of Michigan. F136 878.6 The Life and Death of Differentiated and Dedifferentiated Intestinal Absorptive and Secretory Cells. S.C. Pearce, K. Kishida, S. Yu, N. Gao, R.P. Ferraris. Rutgers New Jersey Medical School, Kindai University, Japan and Rutgers Newark.
879. CELL AND MOLECULAR PROCESSES IN CANCER METASTASIS Poster (Sponsored by: APS Cell and Molecular Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F137 879.1 K-Cl Cotransporter Activity Contributes to Mammalian Cancer Cell Morphology. K.B. Gagnon, M.T. Barati, A. Palumbo, C.A. Conklin, E.D. Lederer. University of Louisville and Robley Rex Veteran Affairs Medical Center. F138 879.2 Cav-1 Upregulation Slows Migration Velocity in BLM Melanoma. S.S. Kinsey, R.w. Baer. A T Still University of Health Sciences.
F139 879.3 Cardiotoxin Iii Suppresses HGF- and EGFInduced EMT and Signaling Network in Breast Cancer MDA-MB-231 Cells. P. Tsai, Y. Fu, L. Chang, S. Hsu, T. Lu. Depratement of Medicinal and Applied Chemistry, Kaohsiung Medical University, Taiwan, Department of Biomedical Science and Environmental Biology, Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Taiwan, Institute of Biomedical Sciences, National Sun Yat-Sen University, Taiwan, Renal Division, Brigham and Women’s Hospital and Harvard Medical School. F140 879.4 Anti-Cancer Effects of Ascorbic Acid and Hyperbaric Oxygen Therapy in Vitro. J.M. DeBlasi, N.P. Ward, A.M. Poff, A.P. Koutnik, C.Q. Rogers, D.P. D’Agostino. University of South Florida.
880. CELL MIGRATION, CONTRACTILITY, CYTOSKELETON, AND ADHESION Poster (Sponsored by: APS Cell and Molecular Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F141 880.1 Macrophage Migration Inhibitory Factor (MIF) but Not Its Homologue D-Dopachrome Tautomerase (D-DT) Promotes Fibroblast Motility in a CD44/CD74-Independent Manner. P. Szczesniak, A. Meinhardt, J. Klug. JustusLiebig University Giessen, Germany and University Hospital Frankfurt, Germany. F142 880.2 Lipid Signaling Regulates Fibroblast Migration and the Actin Cytoskeleton in Response to Stiffness and Microtopography. M. Mkrtschjan, S. Gaikwad, S. Dommaraju, J. Li, B. Russell. University of Illinois at Chicago. F143 880.3 Phyllanthus taxodiifolius Beille Extract Disrupted Microtubule Dynamics in Glioma Cells. J. Kwanthongdee, W. Saengsawang, T. Patoomratana. Faculty of Science and Mahidol University, Thailand. F144 880.4 Mimicking L-Caldesmon Phosphorylation by Decoy Phosphomimetic Peptides on Podosome Formation in RANKL-Induced RAW264.7 Cells. L. Ying-Ming, C. Chang, C. Wang. National Chung-Hsing Universit, Taiwan, National Chung-Hsing University, Taiwan and Boston Biomedical Research Institute. F145 880.5 17b-Estradiol Rescues Low Force Potentiation in Ovariectomized Mice in Vivo. G. Le, G.L. Warren, D.A. Lowe. University of Minnesota and Georgia State University. F146 880.6 Focal Adhesion Kinase Forms Inhibitory Complexes with Its Endogenous Inhibitor. T.J. Zak, S.L. Robia, A.M. Samarel. Loyola University Chicago. F147 880.7 Formyl Peptide Receptor Induces Vascular Unresponsiveness to Noradrenaline via Disruption of Actin Polymerization. C.F. Wenceslau, C.G. McCarthy, R. Webb. Augusta University. F148 880.8 ATP and Extracellular Calcium Regulates Differentially the Phagocytosis of S. aureus and C. glabrata by Macrophages. G. Pérez, C. Hernandez-Silva, J. Arreola, P. Pérez-Cornejo. UASLP, Mexico.
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PHYSIOLOGY MONDAY
881. EXTRACELLULAR MATRIX, CELL INTERACTIONS, AND TISSUE ORGANIZATION Poster (Sponsored by: APS Cell and Molecular Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F149 881.1 The Mechanobiology of Cervical Remodeling: Characterization of Select Cytoskeletal and Rho-GTPase Signaling Factors in Mice Cervical Tissue During Pregnancy. J. Gordon, M. Frank, C.N. Mowa. Appalachian State University and American Physiological Society. F150 881.2 Postpartum Cervical Remodeling Entails Acute Alteration in Expression of Mechanical- And ImmuneRelated Factors. R.L. Stanley, C. Burton, S. Shah, E. Yang, P. Sampathkumar, S. Rao, V. Castillo, V. Douglas, M. Frank, C.N. Mowa. Appalachian State University and American Physiological Society. F151 881.3 Neutrophil Elastase Inhibits Activation of Adhesome Signaling Proteins and Promotes an Inflammatory Phenotype in Airway Smooth Muscle (ASM) Tissue. A.D. Lockett, Y. Wu, S. Gunst. Indiana University. F152 881.4 AGE-RAGE Signaling Is Intersected by Rap1a Crosstalk in Fibroblasts in Diabetic Hearts. J.A. Stewart; Jr., J. Langford, J. Zhao, R. Worsham. Mississippi State University. F153 881.5 Cardioprotective Effects of Lysyl Oxidase Inhibition Against Adverse Extracellular Matrix Remodeling and Cardiomyocyte Apoptosis. E.C. El Hajj, M.C. El Hajj, V.K. Ninh, A.J. Mouton, J.D. Gardner. Louisiana State University Health Sciences Center.
882. NEUROENDOCRINOLOGY/ NEUROIMMUNOLOGY Poster (Sponsored by: APS Central Nervous System Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F154 882.1 Impairment of Osmotic Challenge-Induced Vasopressin Secretion in Sepsis Survivor Rats. N.N. SantosJunior, L.H. Angenendt Costa, C.R. Catalão, A. Kanashiro, T. Sharshar, M.A. Rocha. Ribeirão Preto Medical School, Brazil, Institut Pasteur, France, School of Dentistry of Ribeirão Preto and USP, Brazil. F155 882.2 The Role of AVP on the Immunological Memory in the T-Dependent Antigens Immune Response. A. QuintanarStephano, D.U. Ramírez-Esquivel, A. Organista-Esparza, K. Kovacs, I. Berczi. Universidad Autónoma de Aguascalientes, Mexico and St. Michael’s Hospital, Canada. F156 882.3 CL-K1, a Novel Lectin Pathway Component Is a Leptomeningeal Protein. C. González-Losada, W. CastilloGonzález, J. Jensenius, I. Zerr, M. Schmitz, A.J. DortaContreras. LABCEL, Cuba, Aarhus University, Denmark and Georg-August University, Germany.
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F157 882.4 H Ficolin: Polymerization and Aggregation from Blood to Cerebrospinal Fluid. W. Castillo-González, C. González-Losada, J.A. Rodríguez-Pérez, J. Jensenius, I. Zerr, M. Schmitz, A.J. Dorta-Contreras. Labcel, Cuba, Aarhus University, Denmark and Georg-August University, Germany. F158 882.5 Effects Of Essential Oil on Fear Memory and the Immune Response: A Potential Alternative Therapy for Post Traumatic Stress Disorder (PSTD). C. Moshfegh, A.P. Swiercz, L. Hopkins, C. Hurr, C.N. Young, P.J. Marvar. George Washington University.
883. DIABETES, INSULIN RESISTANCE, AND OBESITY I Poster (Sponsored by: APS Cardiovascular Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F159 883.1 ‘Glucose Tolerance and Triglyceridemia Improve During Acute Caloric Restriction Without Changes in SBP in Obese, Insulin Resistant Rats. M.A. Cornejo, J. Nguyen, J. Cazares, B. Escobedo, A. Nishiyama, R. Ortiz. UC Merced and Kagawa University, Japan. F160 883.2 Euglycemic Clamp in the FATZO/Pco Mouse: A New Model of Type 2 Diabetes. M. Christe, D. Konkol, E. Hawkins, J. Friedrich, J. Jacobs. Eli Lilly and Company. F161 883.3 Fructose-Induced Neurogenic Hypertension Is Mediated by Superoxide Overexpression and Stimulates P38 MAPK-Induced Central Insulin Resistance in the Central Nervous System. H. Chen, P. Cheng, C. Tseng. Kaohsiung Veterans General Hospital, Taiwan. F162 883.4 Cardiac Chronotropic Competence to BetaAdrenergic Stimulation in Insulin Resistance. A.S. Barreto, F.N. Macedo, J.E. Araujo, V.U. Melo, C.O. Dantas, R.d. Barreto, A.G. Guimaraes, J.d. Quintans, L.J. Quintans-Junior, M.R. Santos, V.J. Santana-Filho. UFS, Brazil. F163 883.5 Exercise-Induced Calmodulin Dependent Protein Kinase (CaMK)II Activation Regulates Saturated and Unsaturated Fatty Acids in Rat Skeletal Muscle. E. Mukwevho. North West University, South Africa. F164 883.6 Endoplasmic Reticulum Stress Associated with Purinergic Stimulation. J.P. Reyes, J.R. Castillo-Hernández, M.I. Maldonado-Cervantes, E. Maldonado-Cervantes. Autonomous University of San Luis Potosi, Mexico. F165 883.7 Beta-Hydroxybutyrate Favorably Alters Muscle Cell Survival and Mitochondrial Bioenergetics. B. Parker, B. Dallon, C. Draney, M. Sampson, J. Witt, J. Gibbs, J.S. Tessem, B.T. Bikman. F166 883.8 Beta-Hydroxybutyrate Favorably Alters B-Cell Survival and Mitochondrial Bioenergetics. M. Sampson, D. Lathen, B. Dallon, C. Draney, J. Ray, K. Kener, B. Parker, J. Witt, J. Gibbs, J.S. Tessem, B.T. Bikman. Brigham Young University. F167 883.9 Knockdown of Angiopoietin-Like 2 Mimics the Benefits of Intermittent Fasting on Weight Loss and Insulin Sensitivity in Mice. A. Pinçon, C. Martel, A. Bélanger, M. Gillis, N. Thorin-Trescases, É. Thorin. Montreal Heart Institute, Canada.
MONDAY PHYSIOLOGY F168 883.10 Gene Network and Adipose Transcriptome Analysis of the Northern Elephant Seal During Prolonged Food Deprivation. B. Martinez, K. Rutherford, D. Crocker, N. Gemmell, R.M. Ortiz. University of Otago, New Zealand, UC Merced and Sonoma State University. F169 883.11 Features of Metabolic Syndrome in Male Mice with Deficiency of Estrogen Receptor Alpha. N.C. Winn, T. Jurrissen, G.S. Lin, M.L. Gastecki, R.J. Welly, D.B. Lubahn, V.J. Vieira-Potter, J. Padilla. University of Missouri and Barry University. F170 883.12 Investigating the Role of the Vascular Endothelium in Insulin Delivery. V. Tokarz, Y. Gao, M. Sugiyama, A. Klip, W. Lee. Hospital for Sick Children, Canada and St. Michael’s Hospital, Canada. F171 883.13 Dantrolene Improves Endothelial Function in Type-1 Diabetic Rats by Decreasing Oxidative Stress. M. Roman, S. Alemar, R. Zack, J. Matias, M. Morales, H. Torres, J. Quidgley, M.J. Crespo. University of Puerto Rico-School of Medicine, Puerto Rico. F172 883.14 Glucagon-Like Peptide-1 Treatment Stimulates Neurogenin3 Expression and Pancreatic Beta-Cell Neogenesis in Adult Mice. N. Dadheech, J. Buteau. University of Alberta, Canada. F173 883.15 The Effects of Lisinopril on the Development of Renal Injury Associated with Prepubertal Obesity. A.P. Pennington, K. McPherson, J. Williams. University of Mississippi Medical Center. F174 883.16 Kinetics of Neurotransmitter Metabolism by Monoamine Oxidase in Porcine Heart Differs by Location and Is Increased with Obesity/Metabolic Syndrome. K. Carter, M. Nelson, J. Robidoux, L. Lerman, E. Anderson. East Carolina University, Mayo Clinic and University of Iowa. F175 883.17 Impact of Treadmill Exercise on Endothelial Function During Estrogen Deficiency in Ovariectomized db/db Female Mice. W. Song, Y. Huang. The Chinese University of Hong Kong, People’s Republic of China. F176 883.18 Metformin Decreases Caveolin-1 Expression in Differentiated Human White Preadipocytes but Not in Adipose Tissue from Obese Individuals. M.A. Pfeifer, Y. Zhang, K. Polonis, K.R. Somers, C. Becari, P. Singh. Mayo Clinic. F177 883.19 A Novel Lipidomic Approach to Understand Human Diabetic Heart Disease. I. Pinz, M.P. Robich, S. Ryzhov, D.B. Sawyer, C. Vary. Maine Medical Center. F178 883.20 Neuronal Inflammation: A Potential Contributing Mechanism to High Fat Diet-Induced Neuropathy. D.S. Umbaugh, J.C. Maciejewski, B.L. Guilford. Southern Illinois University Edwardsville. F179 883.21 Heart-Specific Disruption of Bmal1 Leads to Hepatic Insulin Resistance in Mice. T. Nakao, A. Kohsaka, T. Otsuka, H.T. Le, Z.L. Thein, F. Sato, H. Ihara, Y. Muragaki, M. Maeda. Wakayama Medical University, Japan. F180 883.22 Short-Term Methionine Deprivation Improves Metabolic Biomarkers of Obesity. D. Yu, B. Miller, S. Yang, J.A. Wisinski, M. Kimple, V. Cryns, D.W. Lamming. University of Wisconsin-Madison. F181 883.23 ob/ob Mice Fail to Lose Weight on an Alternate-Day Fasting Diet, Yet Improve Glucose Control. M.J. Bingaman, E.M. Hult, S.J. Swoap. Williams College. F182 883.24 The Regulation of Skeletal Muscle InsulinStimulated Signaling by the MEK-REDD1-mTor Axis. D.L. Williamson, C.M. Dungan. Penn State Harrisburg.
F183 883.25 Oral Glucose Tolerance Test in Insulin Resistant Adolescents Induces Regionally Different MacroAnd Microvascular Responses in the Cerebral Circulation. G.L. Peltonen, J.M. Kellawan, A.T. Ward, K.J. Carter, A.L. Carrel, J.L. Rehm, J.M. Oh, B.B. Bendlin, W.G. Schrage. University of Wisconsin-Madison. F184 883.26 A Role for REDD1 on Insulin-Stimulated Signaling Activation Following Acute Treadmill Exercise. C.M. Dungan, D.L. Williamson. Penn State Harrisburg. F185 883.27 Effects of Sleep Duration on Insulin Resistance—A Longitudinal Study in Healthy, Lean, CollegeAge, Males. K. McGregor, K. Cialkowski, D.K. Townsend. Wheaton College.
884. GENOMICS OF OBESITY, DIABETES, CARDIOVASCULAR, KIDNEY AND BEYOND Poster (Sponsored by: APS Physiological Genomics Group) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F186 884.1 CRISPR-Cas9 Gene Editing Yields a Novel Rat Model with Genetic Regulation of Obesity. K.C. Clark, J.M. Pettus, J.L. Grobe, A.E. Kwitek. University of Iowa. F187 884.2 Gut Microbiotal Dysbiosis and Increased Risk for Complex Polygenic Diseases Emerge with Genomic Selection for Low Aerobic Exercise Capacity. Y. Zhang, B. Mell, S. Kumarasamy, X. Cheng, S.L. Britton, L.G. Koch, B. Joe. University of Toledo College of Medicine and Life Sciences and University of Michigan. F188 884.3 Antiaging Gene “Klotho” Deficiency Accelerates Stem Cells Aging by Impairing Telomere. M. Ullah, Z. Sun. University of Oklahoma HSC. F189 884.4 Quantitative Proteomic Analysis of Endothelial Cells in G-Protein Coupled Estrogen Receptor (Gper1) Knockout Rats. S. Galla, H. Waghulde, X. Cheng, S. Chakraborty, B. Mell, V. Basrur, B. Joe. Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Department of Pathology and University of Michigan. F190 884.5 Impaired Blood Pressure Response in Btg2 Mutant Female Rats. M.J. Hoffman, S. Imam, R. Schilling, A. Takizawa, M. Grzybowski, A. Geurts, M.R. Dwinell. Medical College of Wisconsin. F191 884.6 The RGD Phenominer Database and Query Tool: A Resource for Quantitative Phenotypes in the Rat. J.R. Smith, J.L. De Pons, S.J. Laulederkind, G. Hayman, S. Wang, M.J. Hoffman, Y. Zhao, M. Tutaj, O. Ghiasvand, M.R. Dwinell, M.E. Shimoyama. Medical College of Wisconsin. F192 884.7 Loss of Arhgef11 on the Genetic Background of the Dahl Salt-Sensitive (SS) Rat Significantly Attenuates Blood Pressure and Renal Injury. A.C. Johnson, M.R. Garrett. University of Mississippi Medical Center. F193 884.8 Transcriptomic Analysis of the Right and Left Ventricle in Normoxia and Hypoxia (A Model of Pulmonary Arterial Hypertension). M.W. Gorr, K. Sriram, P.A. Insel. University of California San Diego.
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PHYSIOLOGY MONDAY F194 884.9 Transcriptomic Profiling of Tight Junctions Dysfunction in Endothelial Cells and Epithelial Cells in Renal Failure. J. Xu, L. Ho, C. Wu, K. Lim, T. Lu. Harvard University, Harvard Medical School, Chimei Medical Center, Taiwan. F195 884.10 Gα12 Is Required for Renal Cystogenesis Through ADAM10 Dependent Junction Dysfunction Pathway. F. Xu, L. Ho, T. Kong, T. Lu. Brigham and Women’s Hospital and Harvard Medical School. F196 884.11 Identification of Novel Circadian Clock Target Genes Associated with Renal Pathophysiology. M.L. Gumz, K. Solocinski, K. Cheng, G. Wu, J. Hogenesch, D. Montgomery, A.A. Alli. University of Florida and University of Cincinnati.
885. CARDIOVASCULAR ENDOCRINOLOGY
F205 885.9 Prenatal Androgen Exposure of SingleInjection of Testosterone Induces Cardiovascular and Metabolic Dysfunction in Adult Female Wistar Rats. S.B. Sherman, N. Sarsour, J. Hill. University of Toledo College of Medicine and Life Sciences and University of Toledo. F206 885.10 Effects of DHA on Orchidectomy-Associated Alterations in Vascular Responses. D. Villalpando, L. del Campo, R. Navarro, C. Largó, D. Muñoz, M. Tabernero, C. Otero, H. García, M. Ferrer. Facultad de Medicina, UAM, Spain, IdiPAZ, Spain, CSIC, Spain and Instituto Tecnológico de Veracruz, Mexico.
886. ADIPOCYTE FUNCTION AND METABOLISM Poster
Poster (Sponsored by: APS Endocrinology and Metabolism Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F197 885.1 MicroRNA-21 Overexpression Attenuates Aldosterone-Mediated Cardiac Injury and Hypertension. M. Syed, J.P. Ball, H.J. Broome, M.E. Hall, M.J. Ryan, M.E. Hatley, L.L. Yanes Cardozo, D.G. Romero. University of Mississippi Medical Center and St. Jude Children’s Research Hospital. F198 885.2 Smooth Muscle Cell Mineralocorticoid Receptors Are Necessary for Cardiovascular Fibrosis with Aging. S.K. Kim, A. McCurley, J. Dupont, M. Aronovitz, I. Stillman, A. Karumanchi, I.Z. Jaffe. Tufts Medical Center and Beth Israel Deaconess Medical Center. F199 885.3 Adipokines, Obesity, and Sex: Implications for the Central Control of Cardiovascular Function. G.L. Yosten. Saint Louis University. F200 885.4 Functional Innervation of Rat Mesenteric Arteries Is Regulated by Thyroid Hormones. M. Ferrer, M. Ruiz, M. Alameda, A. Sagredo, I. Fernández-Lamo, A. Guadaño. Facultad de Medicina, UAM, Spain, IdiPAZ, Spain and CSIC, Spain. F201 885.5 Effects of Androgens on the Function of Mesenteric Arteries from Normotensive and Hypertensive Rats. L. Isidoro, D. Villalpando, M. Perusquía, M. Ferrer. Facultad de Medicina, UAM, Spain, Instituto de Investigaciones Biomédicas, UNAM, Mexico and IdiPAZ, Spain. F202 885.6 High Casein Diet Differentially Alters FGF21 Levels in Plasma and Cardiac Tissue in Rats. R.J. Pettit-Mee, R.P. Cunningham, N. Sharma. Central Michigan University. F203 885.7 AT1 Receptor Blockade Modifies MAPKs Expression and Attenuates Myocardial Remodeling in Rats Subjected to High-Fat Diet-Induced Obesity. S.A. OliveiraJunior, M.R. Carvalho, G.E. Ota, C.S. Morais, L.U. Pagan, M.J. Gomes, P.F. Martinez, T. Fernandes, E.M. Oliveira, M.P. Okoshi, K. Okoshi, D.H. Campos, A.C. Cicogna. Federal University of Mato Grosso do Sul, Brazil, Sao Paulo State University, Brazil and University of Sao Paulo, Brazil. F204 885.8 Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat. K.R. Somers, C. Becari, K. Polonis, M.A. Pfeifer, P. Singh. Mayo Clinic.
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(Sponsored by: APS Endocrinology and Metabolism Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F207 886.1 Liraglutide Promotes Browning of White Adipose Tissue in Mice with Diet Induced Obesity. F.C. Oliveira, C.M. Ribeiro, C.G. Christ, S. Pereira, B.T. Beserra, J.d. Viana, F.R. Neves, M.S. Coelho, A.A. Amato. Faculty of Health Sciences and University of Brasilia, Brazil. F208 886.2 Effect of Nonylphenol on Adiposity and Glucose Homeostasis in Mice with Diet Induced Obesity. C.M. Ribeiro, F.C. Oliveira, S.A. Pereira, F.R. Neves, M.S. Coelho, A.A. Amato. F209 886.3 Effect of Gut Microbiota Eradication on Adaptive Thermogenesis in Mice. B.T. Beserra, J. Silva, F.C. Oliveira, C.M. Ribeiro, S.A. Perreira, F.R. Neves, M. Coelho, A. Amato. Faculty of Health Sciences and University of Brasilia, Brazil. F210 886.4 The Effects of CTRP3 on Lipid Oxidation in Adult Mouse Primary Hepatocytes. Y. Li, G.L. Wright, J.M. Peterson. Quillen College of Medicine, ast Tennessee State University, College of Public Health and East Tennessee State University. F211 886.5 GPCR Signaling in Brown/Beige Adipose Tissue (Symposium: Adipose Tissue and the Cardiovascular System: Interactions with Sleep and Cardiometabolic Risk Factors). A. Pfeifer. University of Bonn, Germany. F212 886.6 Cold Induced Ucp1 Expression in Brown and White Adipose Tissue of WFS1-Deficient Mice. M. Ehrlich, M. Ivask, S. Kõks. University of Tartu, Estonia. F213 886.7 Inhibition of Estrogen Sulfotransferase and Adipocyte Differentiation by Hydroxylated Metabolites of Lower Chlorinated Polychlorinated Biphenyls. V.S. Parker, E. Squirewell, H. Lehmler, L. Robertson, A. Klingelhutz, M. Duffel. University of Iowa. F214 886.8 Differentiation of Primary Pre-Adipocytes Into Adipose Tissue in a Microfluidic Chip. N. Tanataweethum, F. Yang, A. Zelaya, S. Karnik, R.N. Cohen, E. Brey, A. Bhushan. Illinois Institute of Technology and The University of Chicago. F215 886.9 Brown Adipose Tissue Thermogenic Response in Children with Hypothyroidism. J. Law, L. Robinson, V. Astle, E. Finn, L. Denvir, T. Randell, A. Marshall, H. Sacks, M. Symonds, H. Budge. University of Nottingham, United Kingdom, Monash University, Australia, Nottingham University Hospitals NHS Trust, United Kingdom, University of California and VA Greater Los Angeles Healthcare System.
MONDAY PHYSIOLOGY F216 886.10 Transcriptional Landscape of the Major Adipose Depots During Early Life Reveals Unique Pathways During Development. H. Fainberg, A. Alhaddad, R. Alagal, M. Birtwistle, G. Davies, M. Castellanos, S. May, H. Sacks, H. Budge, M. Symonds. The University of Nottingham, United Kingdom and University of California Los Angeles. F217 886.11 Cold-Induced Metabolic Adjustments in Brown Adipose Tissue and Skeletal Muscle Gene Expression Are Influenced by Time-of-Day. F.S. Machado, Z. Zhang, Y. Su, R. Jansen, E. Foppen, C.C. Coimbra, A. Kalsbeek. Universidade Federal de Minas Gerais (UFMG), Brazil, Academic Medical Center (AMC), University of Amsterdam, Netherlands, Netherlands Institute for Neuroscience (NIN) and Royal Netherlands Academy of Arts and Sciences, Netherlands. F218 886.12 The Anti-Obesity Effect of FGF19 Occurs Independent of the Thermogenic Protein UCP1. R.J. Samms, P. Antonellis, S. Bauer, D. Smith, L. O’Farrell, A. Culver, M. Hamang, J. Perfield, T. Coskun, B. Yaden, R. Gimeno, J. Brozinick, A. Adams. Eli Lilly. F219 886.13 Cross Talk Between Skeletal Muscle and Brown Adipose Tissue During Cold and Diet Induced Thermogeneis. M. Periasamy. Sanford Burnham Prebys Medical Discovery Institute. F220 886.14 Glycolysis Is Required for Rapid Adipocyte Thermogenesis Induced by Cold Stress. M.L. Rexius-Hall, S. Uchiyama, D. Eddington, J. Rehman. University of Illinois at Chicago and University of Tokyo, Japan. F221 886.15 Prior Exercise Training Alters the Response of White and Brown Adipose Tissue to Cold Stress. C.M. Knuth, W.T. Peppler, S.K. Trottier, L.K. Townsend, D.C. Wright. University of Guelph, Canada. F222 886.16 Brown Adipose Tissue Promotes Healthful Aging. J.J. Guers, J. Zhang, S. Yoon, D.E. Vatner, S.F. Vatner. Rutgers University—New Jersey Medical School.
887. ALCOHOLIC AND NONALCOHOLIC FATTY LIVER DISEASES Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F223 887.1 Long-Term Western Diet Feeding Causes Severe NASH and Cecal Dysbiosis in Juvenile Ossabaw Swine. M.R. Panasevich, G.M. Meers, M.A. Linden, J.A. Ibdah, F.W. Booth, J.W. Perfield II, K. Shankar, R.S. Rector. Research Service-Harry S Truman Memorial VA Hospital, University of Missouri, Eli Lilly and Company and Arkansas Children’s Nutrition Center. F224 887.2 Early Postnatal Administration of Oleanolic Acid Attenuates the Development of Non-Alcoholic Fatty Liver Disease in Fructose Fed Adult Female Rats. T.T. Nyakudya, E. Mukwevho, P. Nkomozepi, E. Swanepoel, K.H. Erlwanger. University of Johannesburg, South Africa, University of the Witwatersrand, South Africa and North West University, South Africa. F225 887.3 CRISPR Cas9-Mediated Deletion of Biliverdin Reductase A (BVRA) in Mouse Liver Cells Models a Broad Spectrum of NAFLD Phenotype. S.O. Adeosun, A.C. Nwaneri, T.D. Hinds, D.E. Stec. University of Mississippi Medical Center and University of Toledo College of Medicine and Life Sciences.
F226 887.4 Fish-Oils Increase BAMBI Expression to Protect Against Fibrotic Activity in LPS Stimulated Hepatic Tissue. M.L. Schaller, M.P. Harris, D. Kamm, K.A. Witt, K.E. Sandoval, J.S. Wooten. Southern Illinois University. F227 887.5 Western Diet Feeding Downregulates Hepatic RECK Expression and Induces NASH with Fibrosis. R. Cunningham, R. Sheldon, G. Meers, H. Kandikattu, B. Chandrasekar, R.S. Rector. Harry S Truman Memorial Veterans Medical Center, University of Missouri School of Medicine and University of Iowa. F228 887.6 Palmitate Increases Protein Palmitoylation in Liver Cells. A.L. Estrada, C.M. Stewart, P.Y. Kim, D. Wang, Y. Wei, M. Pagliassotti. Colorado State University and Grambling State University. F229 887.7 Pharmacologic Activation of the SarcoEndoplasmic Reticulum ATPase (SERCA) Reduces PalmitateMediated Endoplasmic Reticulum Stress in Liver Cells. A.L. Estrada, C.M. Stewart, P.Y. Kim, D. Wang, Y. Wei, M. Pagliassotti. Colorado State University and Grambling State University. F230 887.8 The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease. E.K. Kwong, X. Li, R. Liu, P.B. Hylemon, H. Zhou. Virginia Commonwealth University. F231 887.9 The Absence of MSP-Dependent Ron Receptor Tyrosine Kinase Signaling Promotes Unrestrained White Adipose Tissue Expansion, Exacerbated Hepatic Inflammation and Aberrant Hepatic Lipid Metabolism in ApoE-/Mice Fed a High Fat/High Cholesterol Diet. J.N. Allen, A. Dey, J. Zhang, L. Zhang, J. Fraser, M. Kennett, A. Patterson, P. Hankey-Giblin. The Pennsylvania State University. F232 887.10 Modulation of Hepatic Mineral Concentrations in Bile Acid-Induced Fatty Liver. S. Hori, Y. Tanaka, I. Tsuneki, T. Hanai, H. Hara, H. Shimizu, S. Ishizuka. Hokkaido University, Japan and Shimane University, Japan. F233 887.11 CTRP3 Alters Lipid Profile in Response to Ethanol Feeding. A.R. DeGroat, W.A. Clark, K.L. Hagood, J.M. Peterson. East Tennessee State University. F234 887.12 The Effect of Alcohol Consumption on Adipokine Secretion. A.R. DeGroat, J.M. Peterson. East Tennessee State University. F235 887.13 Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease in TRPV1 Null Mice. P. Connell, L. Eusebio, J.N. Fahmy, D.J. DelloStritto, J.M. Ferrell, I.N. Bratz. Northeast Ohio Medical University. F236 887.14 Intestinal HIF-1α Deletion Exacerbates Alcoholic Liver Disease Mediated by Intestinal Dysbiosis and Barrier Dysfunction. T. Shao, F. Li, C. McClain, W. Feng. University of Louisville and Robley Rex VAMC. F237 887.15 Mechanisms of Amelioration of NASH Development by Deletion of the Orphan Nuclear Receptor SHP: Interaction Between Bile Acid and Gut Microbiota. R. Mifflin, C. Kim, J. Park, M. Lee, L. Shriver, H. Barton, Y. Lee. Northeast Ohio Medical University and University of Akron. F238 887.16 Nox1 Inhibition Attenuates Non-Alcoholic Fatty Liver Disease and de Novo Lipogenesis. S. Larion, J. Thompson, J. Butcher, S. Haigh, J. Mintz, S. Khurana, D. Fulton, D. Stepp. Augusta University. F239 887.17 Characterizing a Rat Model to Study the Role Endo-Immunology Plays in Diet-Induced Non-Alcoholic Fatty Liver Disease. G. Hinojosa, A. Hamilton, J. Lora, J.D. Short, R.K. Dearth. University of Texas Rio Grande Valley and University of Texas Health Science Center San Antonio.
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888. GI HORMONES, PEPTIDES AND RECEPTORS Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F240 888.1 miR-195 and RNA-Binding Protein CELF1 Jointly Regulate Translation of IGF2 Receptor in Intestinal Epithelium. Y. Zhang, H.K. Chung, L. Xiao, J. Wu, D.J. Turner, R.N. Jaladanki, J. Wang. University of Maryland School of Medicine. F241 888.2 Expression and Localization of the Major Receptor of Vasoactive Intestinal Peptide (VPAC1) Along the Length of the Intestine. D. Jayawardena, G. Guzman, R. Gill, W. Alrefai, H. Onyuksel, P. Dudeja. University of Illinois at Chicago and Jesse Brown VA Medical Center. F242 888.3 Gene Expression of the GIP and GLP-1 Receptors in the Horse. M.H. Kheder, K. Dudley, M.N. Sillence, M.A. de Laat. Queensland University of Technology, Australia. F243 888.4 FFA2-Mediated 5-HT Release Increases HCO3- Secretion, but Induces Mucosal Injury in Rat Duodenum. K. Maruta, Y. Akiba, I. Kaji, J.D. Kaunitz. UCLA & WLA VAMC. F244 888.5 Identification of Expression and Function of the Glucagon-Like Peptide-1 Receptor in Gastrointestinal Smooth Muscle. A.T. May, H. Wang, S. Mahavadi, J.R. Grider, K.S. Murthy. Virginia Commonwealth University. F245 888.6 Functional Expression of TRPV4 in the Mouse Colon. D. Poole, P. Rajasekhar, C. Nowell, A. Christensen, J. Fichna, N. Bunnett, N. Veldhuis. Monash Institute of Pharmaceutical Sciences, Australia, The University of Melbourne, Australia, Medical University of Lodz, Poland and Columbia University. F246 888.7 GLP-2 Enhances Duodenal SGLT1-Mediated Glucose Absorption via EGF Signaling. I. Kaji, Y. Akiba, J.D. Kaunitz. UCLA.
889. COMPARATIVE METABOLIC AND NUTRITIONAL TOPICS Poster (Sponsored by: APS Comparative and Evolutionary Physiology) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F247 889.1 Repeated Exposure to Food Limitation Earlier in Life Enables Rats to Spare Lipid Stores During Prolonged Starvation. M.D. McCue. St. Mary’s University. F248 889.2 A Pharmacologically Potentiated Stress During Lactation Alters the Hepatic Endocannabinoid System in Adult Mice: Association with Development of Insulin Resistance. M.N. Llanos, V.A. Castillo, P.A. Ponzano, A.M. Ronco. INTA. University of Chile, Chile. F249 889.3 Multi-Tissue Chromatin Modulation During Hibernation. R.S. Dhillon, K.A. Krautkramer, J.M. Denu, H.V. Carey. University of Wisconsin-Madison.
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F250 889.4 Diet Composition Modulates Intestinal Hydrolytic Enzymes in White-Footed Mice (Peromyscus leucopus). L. Wang, W. Karasov. University of Wisconsin-Madison. F251 889.5 Adrenocorticotropin Infusion Stimulates Glucocorticoid-Receptor Mediated Lipolysis in Northern Elephant Seal Pups. P. Juarez, J. Vasquez-Medina, D. Lee, D.E. Croker, R.M. Ortiz. University of California Merced and Sonoma State University. F252 889.6 Use of Low-Density Lipoprotein Receptor and Very Low-Density Lipoprotein Receptor as Potential Genetic Markers to Investigate the Development of Obesity in a NonModel Fish Species, Ictalurus punctarus. N. Ordonez-Castillo, O. Abernathy, R. Spainhour, Y. Kobayashi. Fort Hays State University. F253 889.7 Water Restrictions and Macronutrient Level Intake of Locust. M.I. Diaz, J. Harrison, A. Cease. Northern Arizona University and Arizona State University. F254 889.8 Characterization of Aquaporin Expression and Function in the Malpighian Tubules of the Larval Mosquito, Aedes aegypti. L. Misyura, A. Donini. York University, Canada. F255 889.9 Expression of Sodium-Dependent CationChloride Cotransporters in Adult and Larval Osmoregulatory Tissues of Aedes aegypti Mosquitoes. T.L. Jamil, J. Chen, J.C. Crow, W.G. Kerkhoff, D.C. Akuma, A. McQuiston, P.M. Piermarini, C.M. Gillen. Kenyon College and The Ohio State University. F256 889.10 Sex Differences in the Utilization of Essential and Non-Essential Amino Acids in Lepidoptera. G. Davidowitz, M. McCue, E. Levin. University of Arizona and St. Mary’s University. F257 889.11 The Role of Light and Photo-Oxidative Stress in Coral Bleaching. A. Parrin, N. Blackstone. Harper College and Northern Illinois University.
890. MICROBIOME OF THE GI TRACT Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F258 890.1 Surgical Removal of Gut Bacteria Biomass Promotes Weight Gain via Suppression of Energy Expenditure. N.A. Pearson, R.A. Riedl, S.N. Atkinson, T.L. Ollinger, C.M. Burnett, R.A. Edwards, M. Mokadem, J.R. Kirby, J.L. Grobe. University of Iowa, Medical College of Wisconsin and San Diego State University. F259 890.2 The Biomass and Composition of the Gut Microbiota Modify Anaerobic Metabolism. R.A. Riedl, C.M. Burnett, N.A. Pearson, S.N. Atkinson, T.L. Ollinger, R.A. Edwards, M. Mokadem, J.R. Kirby, J.L. Grobe. F260 890.3 Dietary Fat and Carbohydrate Content Modulate Energy Expenditure via Gut Bacteria. R.A. Riedl, C.M. Burnett, N.A. Pearson, S.N. Atkinson, T.L. Ollinger, G.G. Silva, R.A. Edwards, M. Mokadem, J.R. Kirby, J.L. Grobe.
MONDAY PHYSIOLOGY F261 890.4 Fecal Supernatants from Active Ulcerative Colitis Patients Impair Colonic Epithelial Barrier Integrity and Activate Pelvic Mucosal Extrinsic Afferent Nerves. H.R. Wardill, N. Dmochowska, M.A. Campaniello, C. Mavrangelos, J.M. Bowen, J.M. Andrews, S.P. Costello, P.A. Hughes. University of Adelaide, Australia and Royal Adelaide Hospital, Australia. F262 890.5 Intestinal Dysbiosis During Neonatal Development Alters the Microbiota-Gut-Brain Axis in Adulthood. C.H. Hennessey, J. Sladek, E. Miller, J. Kim, M. Kaur, M.G. Gareau. University of California Davis. F263 890.6 Effects of Exercise Before and During Pregnancy on Microbiomes in High-Fat Fed Pregnant Mice. E. Chung, K.A. Grue, K.R. Kottapalli, G. Kaur, J. Dufour, C. Shen. University of Texas at San Antonio, Texas Tech University and Texas Tech University Health Sciences Center.
891. MICROBES AND NUTRITION Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F264 891.1 Examination of Changes in Intestinal Microbiota Induced by High Fat Feeding in Male Adolescent Rats. M.S. Crawford, C. Whisner, K. Sweazea. Arizona State University.
892. PREBIOTICS, PROBIOTICS AND GUT FUNCTION Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F265 892.1 Control of Lupus Nephritis by the Gut Microbiota. Q. Mu, H. Zhang, X. Luo. Virginia Tech and National Cancer Institute. F266 892.2 Lactobacillus casei Cell-Surface Components and Their Impact on Immunomodulation and Cecal Microbiata Composition. B. Aktas, T.J. De Wolfe, N. Safdar, B.J. Darien, J.L. Steele. Mehmet Akif Ersoy University, Turkey and University of Wisconsin-Madison. F267 892.3 Effects of 1-Kestose Feeding on Cecal Microbiota Which Produce Lactate and Short-Chain Fatty Acids and on Blood Components in Rats. Y. Shimomura, T. Tochio, Y. Kitaura, M. Takahashi, A. Endo. Nagoya University Graduate School of Bioagricultural Sciences, Japan, B Food Science Co., Ltd., Japan, Tokyo University of Agriculture and Faculty of Bioindustry, Japan.
893. CELL BIOLOGY OF DIGESTIVE DISEASES Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F268 893.1 CD44v9 Emerges in Response to Injury and Contributes to the Regeneration of the Gastric Epithelium. N. Bertaux-Skeirik, M. Wunderlich, E. Teal, M. Mahe, N. Sundaram, J. Gabre, J. Hawkins, G. Jian, A.C. Engevik, L. Yang, J. Wang, J.R. Goldenring, J. Qualls, M.A. Helmrath, T. Diwan, J.C. Mulloy, Y. Zavros. University of Cincinnati, Cincinnati Children’s Hospital Medical Center, W.F. Maternal & Child Health Hospital, People’s Republic of China, and Vanderbilt University Medical Center. F269 893.2 The Neurokinin-2 Receptor Antagonist GR 159897 Protects Against Neuroinflammation in the Mouse Enteric Nervous System During Colitis. N.M. Delvalle, B. Gulbransen. Michigan State University. F270 893.3 HMGB2: A Novel Regulator and Potential Therapeutic Target for Liver Fibrosis. Y. Huang, Z. Yang, D. Shin, S. Keshipeddy, D. Wright, A. Costa, D. Burgess, L. Wang. University of Connecticut, Wenzhou Medical University, People’s Republic of China, Veterans Affairs Connecticut Healthcare System and Yale University. F271 893.4 UDCA Treatment Reverses Biliary Proliferation and Hepatic Fibrosis in Mdr2-/- Mice and Human PSC by Decreasing Mast Cell Infiltration and Histamine Release. L.L. Kennedy, L. Hargrove, J. Demieville, F. Meng, P. Invernizzi, G. Alpini, H. Francis. Texas A&M HSC, VA, Baylor S&W and University of Milan-Biocca, Italy. F272 893.5 Regulation of Pancreatic Beta Cell Function by Ankyrin-B. D.N. Lorenzo, J. Hostettler, V. Bennett. University of North Carolina at Chapel Hill, Duke University and Howard Hughes Medical Institute. F273 893.6 Apolipoprotein (apo)AV Deficiency Aggravates Ethanol-Induced Liver Injury, Promoting Progression from Simple Steatosis to Alcoholic Steatohepatitis and Then to Liver Fibrosis in Mice. D.Q. Wang, B. Gao, H.H. Wang, O. de Bari, P. Tso. Saint Louis University School of Medicine, The NIH-National Institute on Alcohol Abuse and Alcoholism and University of Cincinnati.
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894. EFFECTS OF DIET ON GI AND LIVER PHYSIOLOGY Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F274 894.1 Feeding Obese Diabetic Mice a Genistein Diet Induces Thermogenic and Metabolic Change. S. Rockwood, N. Sandoval-Skeet, T.L. Broderick, L. Al-Nakkash. Midwestern University. F275 894.2 Analysis of Jejunal Crypt Morphology from Diabetic Mice Fed Genistein Diet Using Two Methods: Traditional Cryostat and Novel Optical Clearing. N. SandovalSkeet, S. Rockwood, M. Castro, J. Kaufman, T. Riede, L. AlNakkash. Midwestern University. F276 894.3 Dietary High and Low Copper-Fructose Interactions Induce Hepatic Steatosis Associated with Distinct Alterations of Gut Microbial Activity in Male Rats. M. Song, X. Zhang, M. Vos, R. Prough, M. Cave, C. McClain. University of Louisville, Emory University and Robley Rex VAMC. F277 894.4 &ω3-PUFA Supplementation Reduced ALT Levels in Mice Exposed to a Low Linoleic Acid Diet with or Without Ethanol in In a Drinking in the Dark Binge Model. D. Warner, C. Chen, J. Hibbeln, C. McClain, I. Kirpich. University of Louisville, National Institute of Alcohol Abuse and Alcoholism and Robley Rex VAMC. F278 894.5 Genistein Is Associated with Increased Colonic Occludin Expression in Female ob/ob Mice. G. Chompre, J. Hernandez, J. Cerda, I. Seguinot, S. Hernandez, L. AlNakkash, C. Appleyard. Pontifical Catholic University of Puerto Rico, Puerto Rico, Ponce Health Sciences UniversityMedical School & Ponce Research Institute, Puerto Rico and Midwestern University. F279 894.6 High Fat Diet Impacts Colonic and Adipose Tissue Differently in Female and Male Sprague Dawley Rats. L. Sambolin-Escobales, Y. Rodriguez, M.L. Cruz-Rentas, C. Appleyard, G. Chompre. Ponce Health Sciences University. F280 894.7 Purple PotatO Extract Promotes Intestinal Barrier Function and Differentiation by Activating AMPActivated Protein Kinase. X. Sun, M. Du, R. Navarre, M. Zhu. Washington State University and United States Department of Agriculture.
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895. LIVER PHYSIOLOGY AND PATHOPHYSIOLOGY Poster (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F281 895.1 Utilization of Immune Compromised Rats for an Allogeneic Rat Hepatocyte Transplant Model. S.A. Rasmussen, N.P. Rudemiller, A.M. Geurts. Medical College of Wisconsin and Duke University Medical Center. F282 895.2 G Protein-Coupled Receptor 30 (GPR30), a Novel Estrogen Receptor, Plays an Independent Role in the Pathogenesis of Estrogen-Induced Cholesterol Gallstones in Female Mice. D.Q. Wang, O. de Bari, H.H. Wang. Saint Louis University School of Medicine. F283 895.3 Secretin and Secretin Receptor Are Required for Inflammatory Cell-Cell Communication via Extracellular Vesicles Between Cholangiocytes Treated with Lipopolysaccharide. K. Sato, F. Meng, J. Venter, H. Francis, S. Glaser, G. Alpini. Texas A&M Health Science Center and Central Texas Veterans Health Care System. F284 895.4 PHD2/HIF-1α Signaling Mediates Hepatic Metabolic Responses to Moderate Exercise in Cholestasis Mouse Model. B. Luo, P. Chen, D. Xiang, D. Wu, Y. Hu. Shanghai University of Sport, People’s Republic of China, Second Military Medical University, People’s Republic of China, Naval Medical Research Institute, People’s Republic of China, Second Military Medical University, People’s Republic of China. F285 895.5 Inhibition of p53 with Its Specific Inhibitor Pifithrin-α Prevents Hepatic Oxidative Stress and Inflammation, Probably via Up-Regulating Sirt1/Nrf2 Pathway. L. Qian, J. Gu, H. Ji, L. Cai. Kosair Children Hospital Research Institute, University of Louisville, Hangzhou Medical College, People’s Republic of China, First Affiliated Hospital of Jilin University, People’s Republic of China. F286 895.6 Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Rhesus Monkeys Provides the First Animal Model That Accurately Reflects the Human Condition. B.C. Hansen, Z. Liang, F. Sun, Z. Yang, C. Tang, Z. Chen, S. Yubo, Z. Yao, M. Wu, Y. Chen, F. Gao, W. Zeng. University of South Florida, Sichuan Primed Shines Bio-tech.Co, Ltd, People’s Republic of China, Primed, People’s Republic of China.
TUESDAY ANATOMY
TUESDAY, APRIL 25 Anatomy 896. ANATOMY: FORM AND VARIATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E1 896.1 The Anterior Jugular Veins: Preliminary Study. F. Hojaij, L. Santos, B. Souza, J. Pacheco, M. Andrade, F.E. Akamatsu, A.L. Jacomo. University of São Paulo, Brazil. E2 896.2 Lymph Nodes of the Level VI: Anatomic Study of Lymph Nodes Located Between the Recurrent Laryngeal Nerve and the Right Common Carotid Artery. S. Saleh, F. Hojaij, C. Camargo, A.M. Itezerote, M. Andrade, F.E. Akamatsu, A.L. Jacomo. University of São Paulo, Brazil. E3 896.3 Anatomical Variations of Renal Artery Branching in Cadavers. K. Nasr, M. Hurley, M.P. Olivieri, M. Gervasi. D’Youville College. E4 896.4 Anatomical Variation of Arterial Supply to the Prostate in a Cadaver Population. D. Danovskis, M.E. Gervasi, M. Hurley, M.P. Olivieri. D’Youville College. E5 896.5 Anomaly of Double Inferior Vena Cava Due to the Persistence of Left Supra Cardinal Vein Below the Level of the Kidneys. A.R. Nayakanti, K.S. Khurshed, N. Reddy, S.B. Arja, H.S. Shaik, Y. Acharya, S. K R. Avalon University School of Medicine, Netherlands Antilles, JJM Medical College, India and Vinayaka Missions Kirupanandavariyaar Medical College, India. E6 896.6 Asymmetric Supernumeric Renal Arteries: A Case Study. M. Dunnwald, M.A. Pizzimenti. University of Iowa and Carver College of Medicine. E7 896.7 Variation in the Branching Pattern of the Axillary Artery. N. Baur, T. Stinnett, D.J. Green. Midwestern University. E8 896.8 Accessory Brachial Artery—A Unique Variant. S. Ziemann, A. Esterson, S. Sakthi Velavan, S. Rich. Touro College of Osteopathic Medicine. E9 896.9 Arteries of the Skin. Anatomical Study with Guided CT Scan Dissections of the Legs. N. Settembre, Z. Bouziane, M. Labrousse, M. Braun, S. Malikov. Nancy University Hospital, University of Lorraine, Nancy, France, France, University of Lorraine, France and University of Reims, France. E10 896.10 Genetic Background Influences Patterning and Implementation of Stereotypy in the Early Postnatal Mammary Ductal Tree. D. Hadsell, U. Firozi, L. Hadsell, T.C. Cox, A. Lee. Baylor College of Medicine, University of Washington and University of Pittsburgh. E11 896.11 Comparison of 3D Laser-Based Photonic Scans and Manual Anthropometric Measurements of Body Size and Shape in a Swiss Validation Study. F. Ruhli, N. Bender, K. Staub. Institute of Evolutionary Medicine and University of Zurich, Switzerland.
E12 896.12 Complete Bifid Penis in an 84-Year-Old Cadaver. J.R. Martin, Y. Tan, M.W. Rana. Saint Louis University School of Medicine. E13 896.13 Variations in the L4 and L5 Ventral Rami with Iliolumbar Ligaments in 14 Cadavers. P. Kim. Indiana Wesleyan University. E14 896.14 Patterns of Thyrocervical Trunk Variation. E.R. Ballas, S. Inouye. Midwestern University. E15 896.15 Persistent Metopic Suture and Extra Sacral Foramina: Clinically Significant Anatomical Variants. J.M. Gemechu, S.A. Geneti, A.M. Zenebe, S.A. Ewnetu, A.T. Wirtu. Oakland University William Beaumont School of Medicine and Addis Ababa University School of Medicine, Ethiopia. E16 896.16 The Location of the Rib-Cartilage Interface— Importance in Autologous Costal Cartilage Grafting. A.A. Rickards, J. Holmes, M.L. Russell, A.N. Bender-Heine, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E17 896.17 Arrowhead Variation of the Anterior Digastric Musculature. J. Holmes, A.A. Rickards, J.V. Swearingen, K.D. Miller, K.R. Mangus, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E18 896.18 Presence and Variations of the Palmaris Longus in a Small Population. L. Monin, R. Gullekson, M. Hurley, M.P. Olivieri. D’Youville College. E19 896.19 Rare Muscular Variations Identified in a Single Cadaveric Upper Limb: A Four-Headed Biceps Brachii and Coracobrachialis Brevis Muscle Variant. C.W. Moore, C.L. Rice. University of Western Ontario, Canada. E20 896.20 Anatomical Investigation of the Tensor Vastus Intermedius in the Quadriceps Muscle Group. C.T. Collins, L. Figge, R. Reeves, R. Lovely. University of North Texas Health Science Center. E21 896.21 Anatomical and Functional Study of the Accessory Head of the Flexor Pollicis Longus Muscle. J.J. Loescher, E. Williams-Hatala, K.N. Rabey. Midwestern University and Chatham University. E22 896.22 A Case Report and Proposal for the Systematization of Axillary Arch Muscles. J.M. Miller, R. Trelease. UCLA David Geffen School of Medicine. E23 896.23 Rare Bilateral Variation of the Extensor Carpi Radialis Longus Muscle. J.C. Yuan, R.J. Brisson, M. Barremkala, J.M. Venuti, B.J. Thompson. Oakland University William Beaumont School of Medicine. E24 896.24 A Rare Case of Proximal Focal Femoral Deficiency with Overlapping Phenotype of Müllerian duct Irregularity: An Anatomical and Embryological Anomaly. C. Melovitz-Vasan, H. Kitoh, N. Vasan. Cooper Medical School of Rowan University and Nagoya University Graduate School of Medicine, Japan. E25 896.25 Positional Variation of the Mandibular Foramen in African-American Versus Caucasian Populations of Male and Female Human Skulls. M.T. Bee, I. Aljerdi, M. Ciavaglia, A. Elturk, S.T. Barton. University of Detroit Mercy, University of California at San Diego.
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897. ANATOMY: RESPIRATORY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E26 897.1 Development and Structure of the Chorioallantoic Membrane of the Ostrich, Struthio camelus Egg. J.N. Maina, B. Willoughby. University of Johannesburg, South Africa. E27 897.2 Incidence of Right Lung Fissuring and Lobation in Human Cadavers. R. Ettarh, A. Reynolds, S.S. Hassan, A. Govero. California University of Science and Medicine and Tulane University School of Medicine. E28 897.3 Bilateral Accessory Lung Fissures with a Variant Left Bronchial Tree. S. Cohen, B. Rajan, A. Zhandosova, S. Sakthi Velavan. Touro College of Osteopathic Medicine. E29 897.4 Quantitative Characterization of Cadaveric Larynges Using 3-Dimensional Modeling. C.C. Lewis. Samuel Merritt University.
898. ANATOMY: GASTROINTESTINAL Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E30 898.1 Esophageal Anastomosis Pressure Testing to Failure: Full-Thickness or Submucosa-Mucosal? J.M. Aho, S.A. Manzar, K.B. Wise, D.A. Wigle, D.J. Tschumperlin, M.W. Urban. Mayo Clinic Rochester. E31 898.2 Hepato-Diaphragmatic Interposition of the Cecum: A Rare Variant. B. Castellanos, S. Sakthi Velavan, S. Rich. Touro College of Osteopathic Medicine. E32 898.3 Histopathologic Changes in Gastric Mucosa After Experimental Gastric Restriction. G.M. Filho, A.M. Itezerote, S. Saleh, F. Hojaij, M. Andrade, C.A. Martinez, F.E. Akamatsu, A.L. Jacomo. University of São Paulo, Brazil and São Francisco University, Brazil. E33 898.4 Evaluation of Effect of Pausinystaila yohimbe Extract on Liver of Adult Male Wistar Rat. H. Okechukwu, C. Ihentuge, C.O. Ugochukwu, G. Ndukwe. Abia State University, Nigeria, Imo State University, Nigeria and Howard University. E34 898.5 Congenital Left Lobe Hypoplasia of the Liver. V.K. Reddy, A.R. Nayakanti, S.B. Arja, Q. Mohammad, J. Sathluri, M. Patel, S. Agarwal. Avalon University School of Medicine, Netherlands Antilles. E35 898.6 Ambient UFP Exposure Disrupted Gut Vascular Barrier. K. Baek, A. Pieterson, A. Saffari, C. Sioutas, R. Li, T. Hsiai. UCLA and USC.
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E36 898.7 Alfabisabolol Reverses the Morphological Changes Induced by 5-FU in a Model of Intestinal Mucositis. G.S. Cerqueira, J.P. Godoy, J.L. Junior, O.P. Sobrinho, J.R. Medeiros, C.S. Martins, D.V. Costa. University Federal of Piauí, Brazil and University of Brasília, Brazil. E37 898.8 Phylogenetic and Dietary Patterning in the Morphology of Avian Colic Ceca. A. Hunt, A. Lee, L. AlNakkash, T. Riede, H.F. Smith. Midwestern University. E38 898.9 Colonic Mucosa Is Affected by Gastric Restriction in an Animal Model. L.G. Fontes, A. Itezerote, S. Saleh, F. Hojaij, M. Andrade, C.A. Martinez, F.E. Akamatsu, A.L. Jacomo. University of São Paulo, Brazil and São Francisco University, Brazil. E39 898.10 Nonrotation of the Intestine: Embryological and Clinical Correlation. S. Sakthi Velavan, B. Castellanos, N. Gulfam, S. Rich. Touro College of Osteopathic Medicine. E40 898.11 diabetes Mellitus Reduces the Expression of Betatrophin in Pancreatic Islet Cells. E. Adeghate, C. D’Souza, M. Al Balooshi. United Arab Emirates University, United Arab Emirates. E41 898.12 Classification of Type II Diabetes Mellitus Progression Based on Quantification of Pancreatic Histology. L.A. Papazian, Z. Pan, F. LaRosa, L. Lee. University of Colorado.
899. ANATOMY: UROGENITAL Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E42 899.1 Understanding Osteogenesis Through Penis Bone Evolution. N. Schultz, N. Chipalkatti, M.D. Dean. University of Southern California. E43 899.2 Effect of Cyclophosphamide on the Rat Urinary Bladder and the Possible Protective Role of Thymoquinone. S.M. Hassan, G. Al-Eyd, C. Thomann, Z. Ahmad. Californiaa University of Sciences and Medicine (Calmed-SOM), Faculty of Medicine, Cairo University, Egypt and A T Still University. E44 899.3 Development of a Porcine Model to Study the Aortic Plexus and Innervation to the Internal Urethral Sphincter: Implications for Preventing Retrograde Ejaculation. T.S. Beveridge, A.M. Groh, C.W. Moore, A. El-Warrak, M. Johnson, N. Power, B.L. Allman. Western University, Canada, London Health Sciences Centre, Canada and CoSenior Authors, Canada. E45 899.4 Angiogenic, Oxidative and Hormonal Responses of the Prostatic Microenvironment in High Fat Diet-Fed Aging Mice. V.H. Cagnon, C.d. Lamas, T. Hermes, L.A. Kido, E. Minatel, C. Collares-Buzato, M.R. Marostica. University of Campinas, Brazil. E46 899.5 Correlation of Kidney Size to Number of Renal Pyramids in the Goat Kidney. L. Ashton, R. Gullekson, M. Hurley, M. Olivieri. D’Youville College.
TUESDAY ANATOMY E47 899.6 Evaluation of Toxicological Effect of Pausinystalia yohimbe Extract on Histology of Kidney of Adult Male Wistar Rat. C. Ugochiukwu, C. Ihentuge, H. Okechukwu. Imo State University, Nigeria, Howard University and Abia State University, Nigeria. E48 899.7 Rare Bilateral Morphological Variant of the Renal and Gonadal Blood Vessels. A Case Report. D.E. Zahoi, D. Sztika, A. Enache, E. Dăescu. University of Medicine and Pharmacy Victor Babe?, Romania. E49 899.8 Clinical Anatomy of the Perineum Underlies Outcomes of Prostatectomy and Episiotomy. J.H. Plochocki, J.R. Rodriguez-Sosa, S. Ruiz, M.I. Hall. AZCOM and Midwestern University. E50 899.9 Estrogen Receptors β Mediate the Protective Effect of Vitamin B12 on Seminiferous Tubular Epithelium of Cimetidine-Treated Rats. M.A. Eladl, W.M. Elsaed, R.F. Bedeer, M. El-Sherbiny. University of Sharjah, College of Medicine, United Arab Emirates, Mansoura University, Faculty of Medicine, Egypt and Taibah University, Saudi Arabia. E51 899.10 The Anatomic Re-Description of Colles Fascia Using Large Mount Histology. G. Rae. Louisiana State University Health Sciences Center.
900. ANATOMY: ANIMAL MODELS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E52 900.1 Natural Antioxidants and Colorectal Cancer: A New Approach. A. Jurjus, A. Gerges Geagea, S. Al-Kattar, M. Harmouche, S. Harakeh, M. Diab-Assaf, R. Azar, A. Eid, L. Massade, R. Manfredi. American University of Beirut, Lebanon, American University of Beirut, Lebanon, Lebanese University, Lebanon, King Abdulaziz University, Saudi Arabia, Gustave Roussy, France, Metropolitan and University of Palermo, Italy. E53 900.2 Heat Induced by Visible Light Promotes AntiAging Effect in the Skin of Mice. A. Monte-Alto-Costa, M. Santos-Silva, F.S. Schanuel, B. Saguie, B. Romana-Souza. Rio de Janeiro State University, Brazil. E54 900.3 Histological Evaluation of Olive Oil Effects on Skin of Chronically Stressed Mice. B. Romana-Souza, A. Monte-Alto-Costa. State University of Rio de Janeiro, Brazil. E55 900.4 Paraffin Embedded Tissues: Sterile or Contaminated Material? M.D. Barros, B.M. Liquidato, A.I. Adamescu, A.I. Navarini, M.J. Mimica. Santa Casa de São Paulo School of Medical Sciences, Brazil and Carol Davilla University of Medicine and Pharmacy, Romania.
E56 900.5 Immunohistochemical and Cytoarchitectonic Studies of Testes in Triticum aestivum Linn (Poaceae) LectinAdministered Sprague-Dawley Rats. I.E. Okoko, D. Osiagwu, S. Mbagwu, F.I. Duru, A. Osinubi. University of Lagos, Nigeria, Institute of Anatomy, Department of Medicine, University of Fribourg, Switzerland. E57 900.6 EMOSS: A High Resolution Staging System for Mouse Embryos Aged E10–E15. K. Flaherty, M. Musy, J. Sharpe, J. Richtsmeier. Pennsylvania State University and Centre for Genomic Regulation, Spain.
901. ANATOMY: MUSCULOSKELETAL Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E58 901.1 Age-Based Degenerative Joint Disease of Intracapsular Anatomy of the Knee: A Cadaveric Study. J. Immonen, C. Siefring, L. Sanders. Rocky Mountain University of Health Professions and University of Utah. E59 901.2 The Relationship Between the Mc Gregor Ligament, the Masseteric Ligaments and the Deep Fascia of the Infraorbital Region. C. Andretto Amodeo, J. Chevallier, V. Delmas, G. Keller. Casa di Cura La Madonnina, Italy, ANCRE Unité Paris 5 Paris Descartes, France and Dividion of Facial Plastic Surgery UCLA. E60 901.3 Facet Joint Inferior Articular Process Degeneration Following Lumbar Spinal Hypomobility. B.T. Vahey, J.A. Merlo, C. Lawson, J.A. McDowell, A.N. Benckendorf, G.D. Cramer, J.W. Little. Saint Louis University School of Medicine and National University of Health Sciences. E61 901.4 The Incidence of the Fifth Head of Quadriceps Femoris, the Tensor Vanstus Intermedius, and Its Relationship to the Tensor Fasciae Latae. M. Alimohammadi. University of British Columbia, Canada. E62 901.5 Non-Ablative Radiofrequency Enhance Collagen Content on the Injured Achilles Tendon After One Year in Rats. F.E. Akamatsu, A.M. Itezerote, S. Saleh, F. Hojaij, M. Andrade, W. Teodoro. University of São Paulo, Brazil. E63 901.6 Significance of Recognizing Anatomical Variations for Medical Education—An Example of the Triceps Brachii Heads. A.R. McDowell, M.D. Wade, J.M. Ziermann. Howard University College of Medicine. E64 901.7 Hind Limb Perimetry and Muscle Weight in High Intensity Interval Trained Rats. F.S. Fazan, L.F. Almeida, H.D. Francescato, C. Giorgetto, V.S. Fazan. School of Medicine of Ribeirão Preto, Brazil.
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ANATOMY TUESDAY E65 901.8 Physiological Examination of Ratite Orthopedic Disorders and Soft-Tissue Visualization via Micro-CT. T. Green, M. De Miranda Jr., A. Larson, S. Bonitz, P. Gignac, N. Kley, S. Kanatous. Oklahoma State University Center for Health Sciences, Colorado State University and Stony Brook University. E66 901.9 Exploration and Description of Accessory Foot Evertor Muscles. T.M. Greiner. University of WisconsinLa Crosse. E67 901.10 Myokine Signaling Blockade Prevents Androgen Deprivation Therapy Induced Sarcopenia and Suppresses Tumor Growth. C. Pan, S. Singh, J. Krolewski, K. Nastiuk. Roswell Park Cancer Institute. E68 901.11 Supernumerary Rectus Capitis Posterior Muscle in Hylobates agilis. N. Grider-Potter. Arizona State University. E69 901.12 The Anatomy of Pediatric Laparoscopic and Thoracoscopic Procedures—Newer Concepts and Procedures. T. Ghosh. Indian Institute of Morphology, India. E70 901.13 Genu Valgum and Arthritic Changes of the Tibiofemoral Joint in a 97 Year-Old Female. Results of an Independent Dissection and Literature Review in a 3rd Year Anatomy Elective Within a Doctor of Physical Therapy Curriculum. A. Rodriguez, A.H. Amabile. Thomas Jefferson University. E71 901.14 The Relationship Between the Facial Vessels and the Deep Fascia of the Infraorbital Region: A New Concept. C. Andretto Amodeo, J. Chevallier, V. Delmas, G. Keller. Casa di Cura La Madonnina, Italy, ANCRE Unité Paris 5 Paris Descartes, France and Dividion of Facial Plastic Surgery UCLA. E72 901.15 The Gross-Anatomical Plates of the Du Laurens Book, 1627 “Historia Anatomica Humani Corporis”. P.P. Le Floch-Prigent, N. Fromanger, J. Gillot. Université de Versailles-Saint Quentin, France, Metropolitan, Librairie scientifique Alain Brieux, France, Metropolitan and Librairie scientifique Alain Brieux, France.
902. BONES, CARTILAGE AND TEETH Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Bones/Muscle/Connective Tissue Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E73 902.1 Modeling Hypophosphatasia in Ovies aries (Sheep) Using CRISPR/Cas9: Development of Large Animal Models That Phenocopy Rare Human Bone Diseases. D. Williams, C. Pinzon, J. Oldeschulte, S. Huggins, D. Gaddy, L. Suva. Texas A&M University. E74 902.2 Distribution of Cgrp and Bone Remodeling Markers in the Mandible of Senescence Accelerated Mouse. Y. Miwa, M. Sunohara, I. Sato. The Nippon Dental University, Japan.
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E75 902.3 Modulation of Chondrocyte Differentiation by the Hyaline Extracellular Matrix. M.S. Domowicz, J.G. Henry, V.M. Glory, D.S. Vaval, N.B. Schwartz. University of Chicago. E76 902.4 Direct Conversion of Oral Epithelial Cells to Progenitor Dental Mesenchymal Cells by a Novel microRNATranscription Factor Pathway. M.N. Mansaray, T. Sharp, X. Li, C. Huojun, B. Amendt. University of Iowa. E77 902.5 Unravelling the Role of the Vasculature and Extracellular Matrix in Intramembranous Bone Development. T.A. Franz-Odendaal, C. Hammer. Mount Saint Vincent University, Canada and Saint Mary’s University, Canada. E78 902.6 Topographic Analysis of the TMJ Mandibular Fossa Using MicroCT Imaging. S.F. Cobos, Y. Hosein, T. Wilson, A. Tassi, P. Merrifield, K. Galil. Western University, Canada and University of Cuenca, Ecuador. E79 902.7 Factors Associated with Developmental Instability in the Dental Arches of Children. S.F. Miller, L.M. Moreno Uribe, C. Bay, B. Broffitt, S.M. Levy. Midwestern University and University of Iowa. E80 902.8 Serum-Free Culture of Primary Human Gingival Fibroblasts Demonstrates Differences in Collagen Production Between Smokers and Non-Smokers: A System to Measure Effects of Novel Collagenase Inhibitors. P. Mattioli, E. Gambardella, A. Buckley, N. Ruggieri, S. Seutter, K. Green, A. Selim, R. Borghaei, M. D’Angelo. PCOM and Temple University. E81 902.9 Egg Tooth Morphogenesis in the Leopard Gecko: A Model for Dental Size Variation. K.S. Brink, T.M. Grieco, J.M. Richman. University of British Columbia, Canada. E82 902.10 Iroquois 1 (Irx1) Marks the Stratum Intermedium and Periodontal Complex Cells. M. Romero-Bustillos, W. Yu, S. Eliason, B.A. Amendt. College of Dentistry. University of Iowa and University of Iowa. E83 902.11 Morphometric Analysis of Commonly Grafted Costal Cartilages: Considerations for Reconstructive Surgery. M.R. Ganoe, H.L. Lynch, A.N. Bender-Heine, J. Holmes, A.A. Rickards, M.A. Armeni, H. Lambert, M.J. Zdilla. West Liberty University and West Virginia University School of Medicine. E84 902.12 The Depth of Commonly Grafted Costal Cartilages at Different Locations Along the Cartilages: Considerations for Autografts. H.L. Lynch, M.R. Ganoe, A.N. Bender-Heine, J. Holmes, A.A. Rickards, M.A. Armeni, H. Lambert, M.J. Zdilla. West Liberty University and West Virginia University School of Medicine. E85 902.13 Geometric Morphometric Analysis of Costal Cartilage: Considerations for Autograft Selection in Rhinoplasty. M.L. Russell, A.N. Bender-Heine, A.A. Rickards, J. Holmes, M.A. Armeni, H.W. Lambert, M.J. Zdilla. West Liberty University and West Virginia University School of Medicine. E86 902.14 The Anterior Contour of the Seventh Costal Cartilage: Considerations for Grafting to the Nasal Dorsum and Columella. M.L. Russell, A.N. Bender-Heine, J. Holmes, A.A. Rickards, M.A. Armeni, H. Lambert, M.J. Zdilla. West Liberty University and West Virginia University School of Medicine. E87 902.15 Does Palmaris Brevis Structure Allow for Protection Against Prolonged Overlying Compression? an Ultrasound and Immunohistochemical Investigation. C.W. Moore, T.S. Beveridge, C.L. Rice. University of Western Ontario, Canada.
TUESDAY ANATOMY E88 902.16 Accelerometer Assessment of Spinal Joint Crepitus Before and After Spinal Manipulation. G.D. Cramer, M. Budavich, P. Bora, K. Ross. National University of Health Sciences, Boston Scientific and Canadian Memorial Chiropractic College, Canada. E89 902.17 Low Intensity Vibration to Improve Postural Stability, Reduce Chronic Low Back Pain and Improve Function. S.A. McCrae, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. E90 902.18 Metaphysis Repair Process Differ from the Diaphysis. S. Inoue. Department of Oral Anatomy and Developmental Biology and Showa University School of Dentistry, Japan. E91 902.19 Association of Vitamin-D Receptor Polymorphisms with Degenerative Disc Disease in Indian Population. R. Doraiswamy, K. Ramaswami, R. Subramanian, D. Srinivasan, B. Sivasankaran. Karpagam Faculty of Medical Sciences and Research, India, Sri Lakshmi Medical Center & Hospital, India, Nanyang Technological University, Singapore, National University of Singapore, Singapore and Dr.N.G.P Arts and Science College, India. E92 902.20 The Effects of Bone Morphogenetic Protein-7 and Interleukin-1 on Biomechanical Properties of Meniscus Explants. V.W. Taylor II, J. Hicks, C. Ferguson, K. Danelson. Wake Forest School of Medicine. E93 902.21 Comparative Anatomy of the Anterior Cruciate Ligament Insertions in Primates. A. Ruth, M. Raghanti, C. Lovejoy. University of Missouri School of Medicine and Kent State University. E94 902.22 Femoral Fracture Pattern and Its Role in Determining Direction of Impact in a Pedestrian Case. D.J. Porta,T.A. Kress. Bellarmine University and BEST Engineering. E95 902.23 Using 3D Printing to Evaluate Trabecular Bone Mechanical Properties. M.M. Barak, A.M. Black. Winthrop University. E96 902.24 New microRNA Biotechnology to Inhibit Inflammation and Regenerate Bone. B. Amendt, H. Cao, W. Yu, N. Holton, S. Eliason, L. Hong. University of Iowa. E97 902.25 Clodronate Does Not Alter Bone Remodeling in Young Horses. H.A. Richbourg, C.F. Mitchell, M.A. McNulty. Louisiana State University School of Veterinary Medicine and Indiana University School of Medicine. E98 902.26 Histological Identification of Cells Directly Participating Calcified Tissue Resorption and Destruction. M. Nakamura, H. Otsuka. Showa University, Japan. E99 902.27 Serum-Free Cultures of Primary Equine Articular Chondrocytes Demonstrate Differences in Collagen Production and Degradation in Response to Extracellular Matrix Protection Factor (ECPF-1), a Novel Osteoarthritis Therapeutic. A. Buckley, E. Gambardella, N. Ruggieri, D. Whiteman, S. Goswami, O. Osadebe, P. Mattioli, J. Gilbertie, A. Selim, M. D’Angelo. PCOM and University of Pennsylvania.
903. IMAGING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Imaging, Immunohistochemistry and Microscopy Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E100 903.1 3D Imaging Using MRI of a Non-Mineralized Complex Organism: The Jawless Sea Lamprey (Petromyzon marinus) as a Model. B.M. Wood, G. Jia, O. Carmichael, K. McKlveen, D.G. Homberger. Louisiana State University and Pennington Biomedical Research Center. E101 903.2 Fibrosis and Scarring of the Brachial Plexus as Displayed by MRI/MRA/MRV. J.D. Collins, E.H. Saxton, H.A. Gelabert, A.E. Carnes. UCLA and UCSF. E102 903.3 Magnetic Resonance Imaging of Fresh Cadavers: Initial Experiences. C. Harness, M. Lindsay, D. Brien, P.W. Stroman, J.S. Gati, L.W. MacKenzie, B.A. Chronik. Queens University, Canada and Western University, Canada. E103 903.4 Assessment of Commonly Used Measures of Lower Extremity Swelling Following Total Knee Arthroplasty. J. Iannitto, B. Loyd, R. Johnson, C. Eschen, D. Levy, J. Jennings, J. Stevens-Lapsley. University of Colorado and Colorado Joint Replacement. E104 903.5 Subscapularis Plane Block—A Novel Phrenic Nerve Sparing Single Injection Shoulder Block—An Anatomical Study. R. Drake, D. Vissa, M. Johnson, M. Barbeau, R. Soendekoppam Vijayashanker, S. Ganapathy. Western University, Canada, London Health Sciences Centre, Canada and University of Alberta, Canada. E105 903.6 Contrast Enhanced Imaging as an Alternative to Dissection in Tree Shrew (Tupaiidae: Scandentia) Chewing Musculature. H.L. Kristjanson, J.M. Perry. Johns Hopkins University School of Medicine. E106 903.7 Visualizing the Attachments and Internal Architecture of the Masseter Muscle in Cavia porcellus Using Contrast Enhanced Micro-CT. A. Ulm, K. Brennan, J. Iriarte-Diaz, L.A. Lebowicz, C.J. Luciano, C.J. Vinyard, R.E. Druzinsky. University of Illinois at Chicago, and NEOMED. E107 903.8 Novel Methodology for Muscle Volumization: 3D Laser Surface Scanning Meets CT. G. Skerratt, N. Knowles, T. Wilson, L. Ferreira. Western University, Canada.
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904. STEM CELLS, TISSUE ENGINEERING AND REGENERATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Stem Cells/ Regeneration Tissue Engineering/Regeneration Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E108 904.1 Comparative Study of the Mechanical Properties of New PEGSSDA Hydrogels, and Their Effect on Embedded Stem Cell Secretome. T. Azar, N. Cassimatis, M. Dragowich, R. Hashemiyoon, B.B. Ratliff. New York Medical College and Lehigh University. E109 904.2 Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) and Its Associated Gene Network as Potential Regulators of the Glioma Cancer Stem Cell Niche. P.C. Sanchez-Diaz, J.C. Chang, T. Dao, E. Moses, Y. Chen, J.Y. Hung. Rosenberg School of Optometry, University of the Incarnate Word and University of Texas Health Science Center at San Antonio. E110 904.3 Regeneration of Rats Mental Nerve with Mesenchymal Stem Cells Obtained from Dental Pulp of Human Exfoliated Deciduous Teeth. R.T. Sasaki, D.M. Saez, T. Nicoliche, B.G. Monteiro, S.R. Almeida, I. Kerkis, M.C. Silva. Federal University of São Paulo, Brazil, Federal University of Mato Grosso, Brazil, Butantan Institute, Brazil and University of São Paulo, Brazil. E111 904.4 Tracing Cell Movement in the Bladder During Regeneration After Subtotal Cystectomy. R.W. Dettman, M. Devine, G.B. Delos Santos, J.J. Wetterlin, N.A. Kukulka, P.R. Firmiss, D.K. Bowen, E.M. Gong. Northwestern University and Loyola University. E112 904.5 Can Androgens Have Significant Effects on Mesenchymal Stem Cells? P.R. Firmiss, D.K. Bowen, N.A. Kukulka, E.M. Gong, R. Dettman. Northwestern University. E113 904.6 Mesodermal Differentiation of Human Pluripotent Stem Cells Increases Mitofusin-2 Mediated Mitophagy. S. Krantz, L. Wang, P. Toth, G. Marsboom, J. Rehman. University of Illinois at Chicago. E114 904.7 Comparison of Cardiogenic Potential of Induced Pluripotent Stem Cells (iPSCs) Generated from Murine Various Tissues: The Role of Epigenetic Memory in Reprogramming. X. Qi, J. Wang, T. Kantor, W. Huang, W. Cai, J. Liang, C. Paul, D. Freed, Y. Wang. University of Alberta, Canada and University of Cincinnati. E115 904.8 Premature Ovarian Failure Patient-Specific Induced Pluripotent Stem (iPS) Cells Show Compromised Potential to Develop to Germ Cells and Granulosa Cells. C. Lu, Y. Chen, F. Wu, H. Ho, H. Chen. Graduate Institute of Medical Genomics and Proteomics, Taiwan, Department of Obstetrics and Gynecology, Taiwan, Graduate Institute of Clinical Medicine, College of Medicine and the Hospital and National Taiwan University, Taiwan.
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E116 904.9 Finding Closure: Regulated Irf6 Expression Is Required for Proper Wound Healing in Vivo. T. Reeb, F.J. Canady, B. Tesdahl, L.C. Biggs, M. Dunnwald. University of Iowa and University of Helsinki, Finland. E117 904.10 Temporal Distribution of EPAC-1 and EPAC-2 on Normal Skin and Cutaneous Wound Healing of Chronically Stressed Mice. B. Romana-Souza, J. Salles dos Santos, M. Schmidt, A. Monte-Alto-Costa, L. Porto. State University of Rio de Janeiro, Brazil and University of Groningen, Netherlands.
905. MUSCLE Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Bones/Muscle/Connective Tissue Presentation time: O dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E118 905.1 Collagen Analysis of the Achilles Tendon Injured and Treated with F1 Protein. A Study Using Transmission Electron, Polarized Light Microscopy and Western Blot. D.P. Cury, I. Watanabe. University of São Paulo Brazil. E119 905.2 The History Dependence of the EMG-Force Relationship During Ankle Dorsiflexion. J. Paquin, G.A. Power. University of Guelph, Canada. E120 905.3 The Bilateral Deficit Is Not Affected by Residual Force Enhancement of the Elbow Flexors. N. Mazara, G.Z. MacDonald, W. Herzog, G.A. Power. University of Guelph, Canada and University of Calgary, Canada. E121 905.4 Palisade Endings in Cat Extraocular Muscles Develop Postnatally Following Different Time Courses. J. Streicher, M.A. Davis López de Carrizosa, R.R. de la Cruz, Á.M. Pastor Loro, R. Blumer. Karl Landsteiner Univ. of Health Sciences, Austria, Facultad de Biología, Universidad de Sevilla, Spain and Medical Univ. of Vienna, Austria. E122 905.5 HERG1 Expression Increases Calpain Activity in C2C12 Myotubes. L.B. Anderson, E. Pratt, W. Wang, G.H. Hockerman, A.L. Pond. Southern Illinois University and Purdue University. E123 905.6 The ERG1 K+ Channel Protein Is More Abundant in the Denervated Skeletal Muscle of Rodents. B.A. Cobb, L.B. Anderson, S.M. Latour, S. Mosole, J.K. Davie, J. Cheatwood, U. Carraro, S. Zampieri, A.L. Pond. Southern Illinois University, University of Padua, Italy and IRCCS Fondazione Ospedale San Camillo, Italy.
TUESDAY BIOCHEMISTRY
Biochemistry and Molecular Biology 906. DNA REPAIR AND RECOMBINATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B1 906.1 Impact of Histone Mutations on Mismatch Repair and Cancer. J. Fang. Tsinghua University, People’s Republic of China. B2 906.2 Functional Analysis of the Role of Phosphorylated PCNA in Cancer Development and Its Potential in Cancer Therapy. B. Peng, Q. Jiang, J. Ortega, L. Gu, J. Dai, G. Li. Tsinghua University School of Medicine, People’s Republic of China, Tsinghua University College of Life Sciences, People’s Republic of China, and University of Southern California Keck School of Medicine. B3 906.3 Activation of Intra-S Phase Checkpoint Facilitates Tolerance of Replication Stress Caused by Mismatch Repair Processing of DNA Damage. D. Gupta, B. Lin, C.D. Heinen. UConn Health. B4 906.4 Using Transcriptome Analysis to Solve the Puzzle of DNA Repair in Bdelloid Rotifers. C.C. Huber, G. Glazko, Y. Rahmatallah, S. MacLeod, M. Boerma, A. Schurko. Hendrix College and University of Arkansas for Medical Sciences. B5 906.5 Rabbit Polyclonal Antibodies to Detect C7orf49 Proteins Toward Understanding Double Strand Break Repair. B. Englund. Augustana College. B6 906.6 DNA Repeat Expansion and Mismatch Repair: A Recurrent Problem. K.T. Fuselier, E. Grabczyk. LSU Health Sciences Center. B7 906.7 Down-Regulation of Ubiquitin-Specific Protease 24 Regulates DNA Repair by Homologous Recombination in Lung Cancer Cells. S. Wang, Y. Wang, J. Hung. Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National ChengKung University, Taiwan, Institute of Basic Medical Sciences and National Cheng Kung University, Taiwan. B8 906.8 An Investigation of Protein Function During DNA Repair in Bdelloid Rotifers. J.C. McReynolds, M. Boerma, S.D. Byrum, L.M. Orr, A.J. Tackett, A. Schurko. Hendrix College and University of Arkansas for Medical Sciences. B9 906.9 Filament Formation on Double-Stranded DNA Mediates E38K RecA’s Enhanced Activity in the Absence of DNA Damage. M. Ritger, M.M. Cox. University of Wisconsin-Madison. B10 906.10 RECQ1 Interacts with rDNA and Promotes Pre-rRNA Transcription. S. Parvathaneni, X. Lu, S. Sharma. Howard University.
B11 906.11 DNA Polymerase η Is an Important Bypass DNA Polymerase in the Repair of DNA Interstrand Cross-Links. L. Zhao. Central Michigan University. B12 906.12 Characterization of the Interaction Between Mps3 and Cdc5 in Saccharomyces cerevisiae. L. Antoniacci, C. Breymeier. Marywood University. B13 906.13 Identifying the Contribution of Sumoylation and Ubiquitination to Yeast Replication Factor a Function Through the Examination of “Lysine-Less” RFA Mutants. B.L. Senger, S.J. Haring. North Dakota State University. B14 906.14 Development of Novel Nickase Enzymes for Targeted Gene Modification in Higher Eukaryotes. A. Klipp, M. Antoine, E. Kaplan, L. Robins, B. Turner, K. Hillers. California Polytechnic State University San Luis Obispo and University of Washington. B15 906.15 Molecular Mechanisms of Mutagenesis Induced by DNA Repair. B. Shen, J. Chapman, A.V. Furano. NIH. B16 906.16 Development of a Specialized Yeast Strain to Monitor Recruitment Patterns of Saw1 Mediated Rad1-Rad10 Recruitment to DNA Damage Sites Through Single-Strand Annealing. F.E. Fregoso, P.L. Fischhaber. California State University Northridge. B17 906.17 Differential Requirements for Nonhomologous End-Joining (NHEJ) Pathway Genes in DNA Repair and Telomere Stability. N.D. Rodriguez, K. Lewis. Texas State University. B18 906.18 Unstable Telomere Cap Structures in Saccharomyces cerevisiae yku70 Mutants Cause Altered Cell Cycle Phase Distributions. T. Posey, L. Lewis. Texas State. B19 906.19 DNA Double-Strand Break Repair Deficiency Is Associated with Changes in Cell Cycling and Cell Morphology in Saccharomyces cerevisiae. M. Weis, L.K. Lewis. Texas State University. B20 906.20 Exploring the Role of ATP Hydrolysis in the Reca Protein via Stalled DNA Intermediates. L. Sowin, M.M. Cox. University of Wisconsin-Madison. B21 906.21 Purification and Characterization of Deinococcus radiodurans Polynucleotide Phosphorylase a Phosphate Stimulated Mn2+-Dependent Nuclease. M.N. Spence, L. Uranga, S. Lusetti. New Mexico State University. B22 906.22 Effects of DNA Damage on Natural Transformation in Bacillus subtilis B.J. Korry, P.A. Belenky. Brown University. B23 906.23 Stress Response and Natural Transformation in Vibrio cholerae. A.D. Rowan, P.A. Belenky. Brown University. B24 906.24 Acetylpyrazine Thiosemicarbazone Inhibiting Topoisomerase II. L.C. Ngo, G.A. Stults, J. Hill, S.B. Bowman, E.C. Lisic, X. Jiang. Tennessee Technological University.
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907. TRANSCRIPTIONAL ASSEMBLIES AND MECHANISMS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B25 907.1 Activation of Transcription-Coupled 5′-RNA Capping by TFIIH. M. Noe-Gonzalez, J. Conaway, R. Conaway. Stowers Institute and Kansas University Medical Center. B26 907.2 Solution Structures of Biofilm-Controlling Proteins SinI and SinR from Bacillus subtilis Reveal Details of DNA-Binding and Regulatory Mechanism. G.L. Draughn, B.G. Bobay, S.D. Stowe, A.L. Olson, E.A. Feldmann, R.J. Thompson, D.B. Kearns, J. Cavanagh. North Carolina State University, Duke University, Catalent, BASF, Indiana University and RTI International. B27 907.3 Re-Emergence of Chloramphenicol Resistance and Associated Genetic Background in Vibrio cholerae O1. P. Kumar, P. Yadav, A. Nema, A.K. Goel, P.K. Yadava. Jawaharlal Nehru University, India, National Centre for Disease Control, India and Defence Research and Development Establishment, India. B28 907.4 Sensitive and Specific Detection of Ligands Using Engineered Riboswitches. J.P. Laney, D.P. Morse. United States Naval Academy.
908. TRANSCRIPTIONAL REGULATION (II) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Transcriptional Regulation (I), Monday B29 908.1 SOX18 Transcription Factor Interactome: Protein-Protein Interaction a New Road for Anti-Cancer Drug Discovery. M.D. Moustaqil, F. Fontaine, J. Overman, N.D. Giles, A.D. Bhumkar, A.D. O’Caroll, M. Francois, Y.D. Gambin, E.D. Sierecki. EMBL Australia, Australia and Institute of Molecular Bioscience, Australia. B30 908.2 Determining the Effect Environmental Conditions Have on the Activity of the 3′-5′ Exoribonuclease Rrp6. B. McAdoo. St. John Fisher College. B31 908.3 Resolving Specificity over a Large Footprint Distinguishes Androgen and Glucocorticoid Receptor DNA Binding. L. Zhang, G.D. Martini, H.T. Rube, H.J. Bussemaker, M.A. Pufall. University of Iowa, and Columbia University. B32 908.4 Transgene Expression Is Increased When Cells Are Cultured on Defined Biophysical Cues as Detected by a Novel Fluorescence Quantification Method. S.C. Veen, A.J. Youssef, C. Liu, J.Z. Gasiorowski. Midwestern University and The University of Chicago.
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B33 908.5 RXRα Phosphorylation at Threonine 167 Coordinates Energy Metabolism in Mice. T. Sueyoshi, T. Sakuma, S. Shindo, T. Kanayama, R. Moore, M. Negishi. National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. B34 908.6 Functional Characterization of Caprin2 in Mouse Eye Development and Its Associated Developmental Defect Peters Anomaly. N.C. Borders. University of Delaware. B35 908.7 Nutrient Regulation of TATA-Box Binding Protein by O-GlcNAcylation. S. Hardivillé, G. Han, J. Ma, P. Hu, P.S. Banerjee, G.W. Hart. Johns Hopkins University School of Medicine. B36 908.8 A Novel Transcription Factor Regulates the Oxidative Stress Response in Caulobacter crescentus. N.G. Maragos, N. Mohieddin, B. Smolarek, A. Bryan, C. Peterson. Suffolk University. B37 908.9 Angiotensin II-Mediated Repression of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Gene Expression Involving CREB, HSF4a, and HDAC1/2 in Mesangial Cells. K.K. Arise, P. Kumar, K. Pandya, K.N. Pandey. Tulane University Health Sciences Center and School of Medicine. B38 908.10 Selective Regulation of Hypoxia Inducible Factors by Endogenous Ligands. C. Moreno Romero, H. Wang, R. Bruick. St. Mary’s University and University of Texas Southwestern Medical Center. B39 908.11 Regulation of Interleukin 33 by Transforming Growth Factor-β in Epithelia Cells, Fibroblasts and Keratinocytes. J.M. Woelfel, J.P. DenHaese, M.E. Gervasi, S. Ruvio. D’Youville College and D’Youville College. B40 908.12 Regulation of Renal Proximal Tubule Function by CREB-Regulated Transcriptional Coactivators and SaltInducible Kinase. M. Taub, D. KIm, F. Cutuli. University at Buffalo. B41 908.13 Engineering a Tissue-Specific Cell-Based Therapeutic Delivery System. A. Pandey, J.L. Keenan, K.L. Doiron, T. Siggers. Boston University and University of Massachusetts Boston. B42 908.14 Probing the Role of Dynamics in Allosteric Signal Transduction in the CO-Sensing Transcription Factor CooA Using Site-Directed Spin Label EPR Spectroscopy. M.R. Dent, J.P. Hines, D.J. Stevens, J.N. Burstyn. University of Wisconsin-Madison. B43 908.15 The Heme-Binding PAS Domain Mediates Dimerization in the Co-Sensing Transcription Factor BxRcoM-1. R.C. Pinhancos, H.E. Bowman, M.R. Dent, B.H. Young, C.E. Berndsen, J.N. Burstyn. University of Wisconsin-Madison and James Madison University. B44 908.16 Transcriptome Analysis of Conditional Knockout Mice. A.L. Harvey, C. Biefeld, K. Sztroin, J. Zhu, G. Yu, D.R. Dries. Juniata College. B45 908.17 Urinary Proteome Changes Were Detected Earlier Than Serum Biochemical Parameters and Histopathology Changes in a Rat Thioacetamide-Induced Hepatic Fibrosis Model. F. Zhang, Y. Ni, Y. Yuan, Y. Gao. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, People’s Republic of China, Beijing Normal University, People’s Republic of China. B46 908.18 Characterization of Transcriptional Changes in a Vimentin Knock-Out Mouse Model Following Influenza a Infection Using RNAseq. C.M. Koch, J.M. Davis, H. AbdalaValencia, A.V. Misharin, K.M. Ridge. Northwestern University.
TUESDAY BIOCHEMISTRY B47 908.19 Analysis of Differentially Expressed Genes in a Gamma-Secretase Conditional Knockout Mouse. C. Biefeld, A. Harvey, J. Zhu, G. Yu, D. Dries. Juniata College and UT Southwestern. B48 908.20 Polyunsaturated Fatty Acids (PUFA) Enriched Diet Influences Dynamics of Host Genome and Skin Lipidomics Profile: Implications on Mouse Model Simulating Post-Traumatic Stress Disorder (PTSD) Features. N. Chakraborty, B. Sowe, A. Cheema, A. Gautam, R. Hammamieh, M. Jett. The Geneva Foundation, Georgetown University and USACEHR. B49 908.21 High-Throughput Gene Expression Profiling of Myeloid Cells in Mechanically Ventilated Patients with Pneumonia. J.M. Walter, P. Reyfman, K.R. Anekalla, R. Wunderink, A.V. Misharin, M. Chi, G. Budinger. Northwestern University. B50 908.22 Genomic Cell Lineage Analysis Uncovers Novel Endothelial Gene Expression Programs for Metabolic and Immune Regulation. J. Klomp, A. Malik. University of Illinois—Chicago. B51 908.23 mir-140 and mir-6321/miR-6321 Contribute to the Pathogenesis in Acute Myocardial Infarction Revealed by Integrative Study of mRNA and microRNA Transcriptomes. Y. Wang, W. Lin, C. Nugent, R. Zhu, C. Li, L. Zhu, W. Wang. Beijing University of Chinese Medicine, People’s Republic of China, Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, People’s Republic of China, Digestive Diseases and Nutrition Center, Department of Bioinformatics, School of Life Sciences and Technology, People’s Republic of China, Genome and Environment and Microbiome Community of Excellence. B52 908.24 Absolute Quantification of RXRG Isoforms. T. Skotarczak, E. Karnath, L. Monin, Y. Shimanovich, G. Bistulfi. D’Youville College. B53 908.25 Differential Gene Expression and Variant Analysis of Clinical Strains of Cryptococcus neoformans. R. Seipelt-Thiemann, E. McClelland. Middle Tennessee State University.
909. CRISPR: METHODS AND APPLICATIONS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B54 909.1 Further Development of a CRISPR/Cas9 Platform for 60% of Duchenne Muscular Dystrophy Patients. K. Fernandez. University of California at San Diego. B55 909.2 CRISPR/Cas9 Genome Editing to Repair Receptor-Mediated Endocytosis in Homozygous Familial Hypercholesterolemia Induced Pluripotent Stem Cells. L. Omer, E.A. Hudson, J.B. Hoying, N.L. Boyd. University of Louisville. B56 909.3 CRISPR-Mediated Removal of Antibiotic Resistance Genes in Enterococcus faecalis Populations. M. Rodrigues, K. Hullahalli, K. Palmer. The University of Texas at Dallas.
B57 909.4 Cell Penetrating Peptide-Mediated Nuclear Delivery of Cas9 to Enhance the Utility of CRISPR/Cas Genome Editing. D.S. Axford, D.P. Morris, J.L. McMurry. Kennesaw State University. B58 909.5 Multidimensional Chemical Control of CRISPRCas9. C.L. Moore, B. Maji, A. Choudhary, M. Shoulders. MIT, Broad Institute and Harvard Medical School. B59 909.6 Developing a Tagged CRISPR-Cas9 Enhancer Pull-Down Assay. S. Yang, R. Rose. North Carolina State University. B60 909.7 Conserved DNA Motifs in the Type II-A CRISPR Leader Region. R. Rajan, M. Van Orden, P. Klein, B. Kesavan, F. Najar. University of Oklahoma. B61 909.8 Cas9: The Gateway to Genome Engineering. A. Schroeder, N. Mendoza, R. Mahesh, S. Lim, A. Howard. Olathe North High School.
910. RNA PROCESSING AND EDITING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B62 910.1 Deciphering the Dynamics of Alternative PremRNA Processing of Glutaminase in Ovarian Cancer. P.R. LaFontaine, B. Gibbs, C.P. Masamha. Butler University. B63 910.2 Using Cryo-Electron Microscopy to Discover Box C/D s(no)RNP Structure. S.J. Baserga, W. Yip, H. Shigematsu, D.W. Taylor. Yale University, RIKEN Center for Life Science Technology, Japan, University of California at Berkeley. B64 910.3 Functional Significance of Intermediate Cleavages in the 5′ETS of Schizosaccharomyces pombe PrerRNA. W. Van Loggerenberg, S. Nellimarla, J. Park, R.N. Nazar. University of Guelph, Canada. B65 910.4 BDF2 Transcript Sensitivity to RNase IIIMediated Decay Is Heavily Governed by Its Transcript Localization and Vulnerability to Cleavage. C. Wang, K. Roy, G. Chanfreau. UCLA. B66 910.5 Biochemical Investigation Into Novel Activities of Yeast SPOUT-Superfamily RNA Methyltransferases. H. Mast, A. Hoskins. University of Wisconsin-Madison. B67 910.6 How the Splicing Factors Cus2 and Prp5 Influence Global Splicing Efficiency in Yeast. A. Clark, I. Norden, A.A. Hoskins. University of Wisconsin-Madison. B68 910.7 A Possible Conserved Role for SR Protein Kinase in the Regulation of Cell Death. V.E. McGhee, S.M. Patel, E.S. McDonald, G.B. Whitworth. B69 910.8 Structural Characterization of the Recognition of U6 snRNA by the Yeast U6 Biogenesis Protein Usb1. A.T. DeLaitsch, A.L. Didychuk, E.J. Montemayor, M.A. Larson, S. Lucarelli, S.E. Butcher. University of Wisconsin-Madison. B70 910.9 Exploring Dib1’s Role in Pre-mRNA Splicing. C.C. Schreib, C. Hernandez, E. Bowman, A. Lucas, C. Maeder. Trinity University, University of Chicago and Carnegie Mellon University.
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BIOCHEMISTRY TUESDAY B71 910.10 Genetic Delivery of RNA Molecules to Alter Expression of EGFR in Brain Cancer Cells. N. Sivetz, S.C. Falotico, P. Nekrasov, M.J. Hicks. Monmouth University. B72 910.11 Understanding How Two Similar RNA Binding Domains Mediate Different Protein-Protein Interactions. C. Marshall. California State University at Fullerton. B73 910.12 Crystal Structure of the Varkud Satellite Ribozyme: Peek Into Trans-Active Enzymes of the RNA World. S. DasGupta. The University of Chicago.
911. RNA TURNOVER Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B74 911.1 Structural and Functional Characterization of a Human Ribonuclease Implicated in Obesity. E. Abshire, J. Chasseur, J. Bohn, P. DelRizzo, A. Goldstrohm, R. Trievel. University of Michigan and University of Minnesota. B75 911.2 Postmortem Samples from Aviation Accident Victims Maintain Tissue-Specific mRNA Expression Profiles. D. Burian, D.C. Hutchings, H.A. Uyhelji, D.L. Williams, V.L. White. Federal Aviation Administration, Venesco, LLC and Cytovance Biologics. B76 911.3 Deficiencies in RNS2-Mediated Ribosomal RNA Turnover Cause Changes in the Pentose Phosphate Pathway Flux and Alter Cell Growth in Arabidopsis. G.C. MacIntosh, S. Morriss, X. Liu, D. Bassham. Iowa State University. B77 911.4 The Sbp1p Paralog Rnp1p Has a Role in P-Body Assembly Without Affecting Translational Repression. S.P. Segal, A. Chanhthee, K. Mackay. Winona State University. B78 911.5 Design of a Gene Transfer Vector to Deliver a Stabilized Anti-EGFR RNA Aptamer to the Glioblastoma Microenvironment. S. Parikh, M.J. Hicks. Monmouth University.
912. PROTEIN INTERACTIONS AND BINDING (III) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Interactions and Binding (I), Sunday Protein Interactions and Binding (II), Monday B79 912.1 Investigation of ck/MyosinVIIA Interactors Using Affinity Tagged C-Terminal Binding Domains. T.M. Halverson, J.L. Sallee. North Central College. B80 912.2 Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. S.K. Zepeda, M.A. Villarreal, N.M. Biediger, N.A. Bonner, J.N. Miller, B.J. Ricard, D.M. García, K.A. Lewis. Texas State University. B81 912.3 Investigating the Role of a Dual Motif in DNA Binding by PAX3-FOXO1. A. Weatherspoon, R. Evans, T. Cherlin, M. Bratton, K. Johanson. Xavier University of Louisiana.
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B82 912.4 Investigating Contributions of the N and C Terminus to FOXO1 and DNA Interactions. J.M. Stenson. Xavier University of Louisiana. B83 912.5 Characterization of a Novel Apolipophorin-III/ Apolipoprotein E C-Terminal Domain Chimera. L.M. Kakutani. California State University at Long Beach. B84 912.6 DNA Binding by a HEAT-Repeat Subunit of Saccharomyces cerevisiae Condensin. R. Sarkar, V.V. Rybenkov. The University of Oklahoma. B85 912.7 Elucidating Met18 Functionality in Iron-Sulfur Cluster Biogenesis. C.Y. Lee, A. Vo, J. Cosman, D. Perlstein. Boston University. B86 912.8 Protein-Protein Interactions in Nickel Acquisition of Escherichia coli. Z. Zeng, D. Zamble. University of Toronto, Canada. B87 912.9 L-Arginine Inhibits a Critical Structural Contact Required for Transcription of the IL1B Gene Coding for Human Interleukin 1β. S.H. Pulugulla, N.W. Rutter, E.X. Esposito, Z. Yang, J.D. Madura, P.E. Auron. Duquesne University, exeResearch, LLC and Pfizer Research Technology Center. B88 912.10 Characterization of Macromolecular Interactions That Influence Pichia pastoris Vac8p Function in Microautophagy. J.T. Bellmore, E.S. Potokar, J.A. Morales, S.D. Patel, M.R. Fry. Bradley University. B89 912.11 Nanobody Mediated Neutralization of Listeria monocytogenes. C. Brooks, I. Huh, M. Toride, A. Shenai. California State University Fresno. B90 912.12 Functional Role of the N-Terminal Region of bHLH TWIST Proteins in the DNA-Binding Activity of ADD1/ SREBP1c. Y. Rodriguez, C.L. Cadilla. UPR School of Medicine, Puerto Rico. B91 912.13 The Role of the C1q Domain of Otolin1 in Otolith Morphogenesis. O. Das. SUNY Downstate Medical Center. B92 912.14 Studies on HIV-1 RNA-Protein Interactions. N. Hadler, E. Stockdale, K. Wise, I. O’Carroll. US Naval Academy. B93 912.15 Exploring a Possible Role in Copper Transport and Storage for the Vitamin Carrier, Riboflavin Binding Protein. S. Smith, M. Benore. University of Michigan-Dearborn. B94 912.16 Investigating the Role of the Human Parvovirus B19’s Main Viral Protein, NS1, in Viral Replication and Interactions with Host DNA. C.J. Hernandez, J.L. Sanchez, N.C. Horton. University of Arizona.
913. PROTEIN STRUCTURE AND BIOPHYSICS (III) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Structure and Biophysics (I), Sunday Protein Structure and Biophysics (II), Monday B97 913.1 Extraction of Protein Thermodynamic Parameters from High-Throughput Differential Scanning Fluorimetry Assays. T. Wright, J. Stewart, D. Konkolewicz, R.C. Page. Miami University. B98 913.2 β-Helix Structural Stability and Malleability Affords Both a Buried Water Network and an Unoccupied 200 å3 Void. T. Weaver, B. Bhattacharyya, W. Novak. University Wisconsin La Crosse and Wabash College.
TUESDAY BIOCHEMISTRY B99 913.3 Insights Into the Catalytic Mechanism and Transition State Stabilization of 5′-Methylthioadenosine Nucleosidase Using Neutron Crystallography. M.T. Banco, V. Mishra, A. Ostermann, T.E. Schrader, G.B. Evans, A.Y. Kovalevsky, D.R. Ronning. University of Toledo, Heinz MaierLeibnitz Zentrum, Germany, Victoria University of Wellington, New Zealand and Oak Ridge National Laboratory. B100 913.4 Functional Characterization of a CysteineLess Isoform of the Human GLUT2 Hexose Transporter. A.M. Reyes, A.A. Pérez, M. Vargas-Uribe, C. Elgueta, A. Cuevas, L. Ojeda, R. Arce, M. Salas. Universidad Austral de Chile, Chile. B101 913.5 Computational Analysis of CHP-NHE ProteinProtein Interaction. I.W. Bell, J. Latzer, J.J. Provost. University of San Diego and Southwestern College. B102 913.6 Recruitment of Drp1 in Mitochondrial Fission. J.M. Egner, A. Bakkum, A. Gardner, B. Hill. Medical College of Wisconsin. B103 913.7 Selecting Medically Relevant in Vitro Protein Characterization Projects with a High Potential for Success. D. Zajac, B. Tucker, A. Cotsoradis, C. Mallmann, C. Cassidy, D. Gurnon. DePauw University. B104 913.8 Purification and Characterization of CloverRuby2 as a FRET Substrate for Protease Assays. T.L. Selby. Mercer University School of Medicine. B105 913.9 The Role of a Highly Conserved Loop in Response Regulator Activation in the General Stress Response. D.S. Eaton, J.L. Luebke, S. Crosson. University of Chicago. B106 913.10 Understanding a Fundamental Force in Protien Folding: Tuning the n [→] π* Interaction in Designed Peptides. N. Wenzell, H. Ganguly, A. Pandey, G.P A. Yap, N.J. Zondlo. University of Delaware. B107 913.11 Secondary Structure Analysis of the C-Terminus of Ga-interacting Vesicle Associated Protein Using Circular Dichroism Spectroscopy. A.L. Maddox, D. Bhandari. California State University at Long Beach. B108 913.12 Structural Characterization of SOD4 from Candida albicans. K. Randolph, A. Galaleldeen. St. Mary’s University. B109 913.13 Evaluating the Role of a Multi-Heme Cytochrome c in Electron Transfer from an Electrode Surface to Heliobacterium modesticaldum. K.A. Herrera-Theut, C. Gisriel, J. Laureanti, G. Orf, P. Baker, A.K. Jones, K. Redding. Arizona State University. B110 913.14 Structural Insights Into the Interaction Between Autophagy-Regulating Protein BECN1 and GAPR-1. Y. Li, M. Su, Y. Zhao, C. Colbert, B. Levine, S. Sinha. North Dakota State University and UT Southwestern Medical Center and HHMI. B111 913.15 Ras Residue Y71 Promotes Flexibility of Switch I and Switch II. H. Guterres, C. Mattos. Northeastern University. B112 913.16 Conformational Landscape of the Protein Kinase A Inhibitor PKI Studied by Fluorescence and NMR Spectroscopy. C. Olivieri, G. Li, J. Kim, F. Porcelli, M. Neibergall, J.M. Muretta, D.D. Thomas, S.S. Taylor, V. Gianluigi. University of Minnesota, University of Tuscia, Italy, Bethel College and University of California at San Diego. B113 913.17 Crystal Structures of a Bacteriophytochrome from Myxobacteria Stigmatella aurantiaca. P.M. Waltz, A. Halavaty, H. Patel, J. Hopkins, N. Woitowich, E. Stojkovic. Northeastern Illinois University and Northwestern University. B114 913.18 Evaluation of a Prefusion Model of the Herpesvirus Fusion Protein via Mutagenesis. C.A. Robinson, S.L. Gallagher, S.A. Connolly. DePaul University.
B115 913.19 Investigation of the Molecular Basis of pHInduced Dna Binding of CooA, a CO-Sensing Transcription Factor. B. Weaver, G. Westerlund, C. McGhiey, S. Markovic, R. Clark. Valparaiso University. B116 913.20 A Conserved Active Site Residue Favours Metal Ion Binding by Destabilizing Apo-Protein. A. Miller, T. Wang. University of Kentucky. B117 913.21 NMR Structural Studies of Stress Responsive Peptide-2 from the Insect Manduca sexta. L. Schrag, X. Cao, A.I. Herrera, Y. Wang, H. Jiang, O. Prakash. Kansas State University and Oklahoma State University.
914. INTRINSICALLY DISORDERED PROTEINS AND AMYLOIDS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B118 914.1 Capillary Dilatometry, in Conjunction with UV Spectrophotometry, Measures Conversion of Insulin to Polymeric Protein Fibrils (Amyloid). P.J. Carman, P.C. Kahn. Rutgers University. B119 914.2 Stress-Triggered Phase Separation, Tuned by Unusual Features of an Intrinsically Disordered Region, Promotes Cellular Fitness During Stress. J.A. Riback, C. Katanski, J.L. Kear-Scott, T.L. Sosnick, D. Drummond. University of Chicago. B120 914.3 Expression, Purification, and Characterization of an Intrinsically Disordered Late Embryogenesis Abundant (LEA) Protein from Artemia franciscana Utilizing Escherichia col and Nicotiana tabacum. M. Karim, Y.S. Yordanov, M.A. Menze. Eastern Illinois University and University of Louisville. B121 914.4 Transport of the Alzheimer’s Disease Associated Amyloid-Beta Peptide by P-Glycoprotein. J.W. McCormick, A.K. Nanayakkara, P.D. Vogel, J.G. Wise. Southern Methodist University, The Center for Drug Discovery, Design and Delivery (CD4), The Center for Scientific Computation, The Center for Drug Discovery, Design and and Delivery (CD4). B122 914.5 Rosmarinic Acid, a Catechol-Containing Natural Product, Potently Inhibits Amylin Amyloidosis. P.W. Velander, L. Wu, K. Ray, S. Zhang, R. Helm, D. Bevan, B. Xu. Virginia Tech and Virginia Commonwealth University. B123 914.6 An Engineered Bacterial Display System for the Development of a High-Throughput Screen for Compounds That Block Amyloid Fiber Formation. J. Love, M. Soo Ko. San Diego State University. B124 914.7 Regulatory Role of Non-Phosphorylated Tau 441 and Its Antibodies on Tubulin Polymerization. M.M. Imhof, N.L. Zabik, S. ‘Martic. Oakland University. B125 914.8 Modulatory Role of Anti-Tau Antibodies on Phosphorylation of Tau-441 by MARK4. I. Ziu, S. ‘Martic. B126 914.9 High Throughput Quantification of Nucleated Protein Phase Behavior in Vivo. R. Halfmann, T. Khan, E. Bruner, T. Kandola. Stowers Institute for Medical Research and University of Kansas Medical Center.
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BIOCHEMISTRY TUESDAY B127 914.10 Quantitative Sequence Specific Protein Footprinting Reveals Structural Details of Amyloid-β (1-42) Peptide Oligomerization. A.L. Klinger, J. Kiselar, A.J. Nix, A. Paravastu, T.L. Rosenberry. DecipherBio, Case Western Reserve University, Mayo Clinic and Georgia Tech. B128 914.11 ALS and Ubiquilin-2: Effects of ALS Mutations on Ubiquilin-2 Structure and Function. C. Castaneda, T. Dao. Syracuse University. B129 914.12 The B Domain of the Mitochondrial Fission Mechanoenzyme Drp1 Is Intrinsically Disordered and Coacervates Under Crowding Conditions. B. Hill, A. Posey, M. Bagheri, N. Kennedy, M. Khan, J. Harden. Medical College of Wisconsin, Johns Hopkins University and University of Ottawa, Canada.
915. PROTEIN TURNOVER AND QUALITY CONTROL Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B130 915.1 Ubiquitin-Dependent and -Independent Degradation of p35 Activation Subunit of Neuronal Cdk, Cdk5. T. Takasugi, S. Minegishi, T. Saito, H. Kawahara, S. Hisanaga. Tokyo Metropolitan University, Japan. B131 915.2 Determination of Protein Turnover in E. coli Cells During Exit from Persistence. M. Semanjski, E. Germain, K. Gerdes, B. Macek. University of Tuebingen, Germany and University of Copenhagen, Denmark. B132 915.3 Effects of Endoplasmic Reticulum Stress on Protein Quality Control. B.W. Buchanan, E.M. Rubenstein. Ball State University. B133 915.4 A Neuronal-Specific Surface-Exposed Membrane Proteasome Complex Modulates Neuronal Signaling Through Extracellular Signaling Peptides. K.V. Ramachandran, S.S. Margolis. Johns Hopkins School of Medicine. B134 915.5 Genetic Requirements for the Degradation of Translocon-Associated Proteins. C.J. Indovina, S.M. Engle, S.G. Watts, E.M. Rubenstein. Ball State University. B135 915.6 Shifting Sands: Modulating Interactions and Outputs of the CHIP-Hsp70/HOP-Hsp70 Protein Quality Control Complexes. R.C. Page, H. Zhang, K. Cottingim, J. VanPelt, J.C. Nix, J. Schisler. Miami University, Lawrence Berkeley National Laboratory, University of North Carolina at Chapel Hill. B136 915.7 Repeat Expanded Ataxin-1 mRNA and Protein Is Co-Regulated at PML Bodies. D. Fanslow, A. Cogswell, C. Strojny, A. Garza-Gongora, E. Smith, S. Kosak. Northwestern University.
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916. UBIQUITIN PATHWAY AND TARGETING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B137 916.1 A Role of Deubiquitinating Enzyme Ubp3 in Coping with Oxidative Stress. X. Jin. Saint Louis University. B138 916.2 Withdrawn. B139 916.3 Multivalent Interactions Between a Ubiquitin Ligase and Its Substrates Mediate Their Recruitment to Liquid Membrane-Less Organelles. T. Mittag, J. Bouchard, E. Martin, J. Otero, S. Marada, S. Ogden. St. Jude Children’s Research Hospital. B140 916.4 Ubiquitin Specific Peptidase 24-Mediated Interleukin 6 Expression in Tumor-Associated Microenvironment Promotes Tumor Malignancy. Y. Wang, Y. Wu, W. Chang, J. Hung. National Cheng Kung University, Taiwan and Taipei Medical University, Taiwan. B141 916.5 Conformational Locking and Unlocking in the Ubiquitin Family of Proteins. R.T. Kelly, C. Berndsen. James Madison University. B142 916.6 Which Polyubiquitin Polymer(s) Is Responsible for Mitophagy in Yeast Cells? T.D. Hoskins, E. Cooper. Hartwick College. B143 916.7 Ubiquitin-Mediated Endocytosis Achieves pH Homeostasis by Facilitating Communication Between Intracellular V-ATPases and a Plasma Membrane Proton Exporter. S. Velivela, P.M. Kane. SUNY Upstate Medical University. B144 916.8 Interactions and Dynamics Within CHIP/ Hsp70 Complexes. M.M. Mannion, H. Zhang, J. VanPelt, K. Cottingim, S. Tsutakawa, R.C. Page. Miami University and Lawrence Berkeley National Laboratory. B145 916.9 Effects of VACM-1/Cul5 Gene Knockout on Cellular Proliferation Using CRISPR-Cas9 Approach. C. Gager, S. Rios, M. Cunningham, M. Burnatowska-Hledin. Hope College. B146 916.10 Remodeling the Actin Cytoskeleton by Ubiquitin-Dependent Proteolysis. K.M. Mannix, J. Gerdes, A. Hudson, R. Kaufman, L. Cooley. Yale University. B147 916.11 Effect of Rad 23 Selectivity to Polyubiquitin Chain Linkage on Far-1 Degradation in Yeast. Y. Liu, E. Cooper. Hartwick College. B148 916.12 Molecular Mechanism of JNK Attenuation by Parkin. C.W. Davis, X. Zhan. Tennessee Tech University.
TUESDAY BIOCHEMISTRY
917. PROTEASOMES: STRUCTURE AND REGULATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B149 917.1 Pba3-Pba4 Plays a Role in Preventing Non-Productive Interactions Among the α Subunits of the Proteasome. D. Panfair, A. Ramamurthy, M. Hochstrasser, A. Kusmierczyk. Indiana University-Purdue University Indianapolis and Yale University. B150 917.2 Molecular Chaperones of the Hsp70 Family Interacting with the Proteasome Assembly Network. L.J. Hammack, K. Firestone, A.R. Kusmierczyk. Indiana University-Purdue University Indianapolis. B151 917.3 Proteasome’s Proteases Are Altered During Priming, Inflammation and Tolerance by LPS. N. Qureshi, N. Silswal. University of Missouri. B152 917.4 Proteasome Activation via a Functional Switch of the Rpt6 C-Terminal Tail Following ChaperoneDependent Assembly. S. Park, F. Li, V. Sokolova. University of Colorado Boulder. B153 917.5 Proteasome Assembly and the Formation of Non-Canonical Complexes in Vivo. A.R. Kusmierczyk, L.J. Hammack. IUPUI. B154 917.6 Nitrogen Starvation and Rapamycin Both Induce Autophagic Degradation of Proteasome Complexes. J. Roelofs, K.A. Waite, G. Vontz, A. De La Mota-Peynado. Kansas State University. B155 917.7 Resveratrol: Proteasome Inhibitor and Immunomodulator. N. Silswal, N. Qureshi. University of Missouri Kansas City. B156 917.8 This Is SPrTAC: A New Method to Distinguish Multisubunit Complexes with Highly Similar Compositions in Vivo. R.J. Tomko Jr., A.K. Peterson. Florida State University College of Medicine.
918. PROTEOLYTIC ENZYMES AND INHIBITORS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B157 918.1 ScMC4 and ScMC5 Are Metacaspases Active in Cleaving Peptides After Arg Residues. M. McDonald, K. Fox. Union College (NY). B158 918.2 ScMC2 Is a Calcium-Dependent Metacaspase Cleaving Peptides After Arg Residues. S.N. Scharbach, K. Fox. Union College. B159 918.3 Identifying a Serine Protease Network Involved in Ovarian Cancer Progression Using Activity-Based Protein Profiling (ABPP). C. Mehner, A. Hockla, D.C. Radisky, E.S. Radisky. Mayo Clinic. B160 918.4 Label Free Proteomics Profiling of ThrombinActivated Platelets Highlights the Down-Regulation of the Integrin and RhoA/ILK Signaling Pathways in Response to the Treatment with Direct Thrombin Inhibitors. C.C. Clement. Albert Einstein Coll Med CUNY. B161 918.5 Structural and Biochemical Insights Into the Activation and Substrate Selectivity of Clostripain-Like Proteases Secreted from Commensal Gut Bacteria. E.J. Roncase, A.J. O’Donoghue, D.W. Wolan. The Scripps Research Institute, University of California at San Diego. B162 918.6 The Effect of Disrupting a Distal Hydrogen Bond Network on Serine Protease Function. R. Villa, T. Baird; Jr. San Francisco University. B163 918.7 The Effect of a Y39A Substitution in Trypsin and Its Interaction with Macromolecules—Implications for the Development of Protease Therapeutics. A. Adame, P. Huang, T. Baird Jr. San Francisco State University. B164 918.8 Site-Directed Mutagenesis of Recombinant Aedes aegypti Trypsin-Like Serine Proteases II and IV (AasSPII and AaSPIV). D.F. Eilerts, A.A. Rascon; Jr. San Jose State University. B165 918.9 Biochemical Studies of Recombinant AaCHYMO from the Female Aedes aegypti Mosquito. O. Burata, A.A. Rascon; Jr. San Jose State University. B166 918.10 In Vitro Activation of Purified Aedes aegypti Mosquito Early Trypsin (AaET) Wild-Type in Comparison to the Inactive AaET Mutant (Active Site Serine to Alanine). R.M. Lucero, A.A. Rascon; Jr. San Jose State University. B167 918.11 Inhibition of Eurygaster integriceps Puton Prolyl Endoprotease (spPEP) and Human Prolyl Endopeptidase (hPEP) Using αS1–Casein Peptide Inhibitors. P. Kadakova. Stephen F. Austin State University. B168 918.12 Withdrawn. B169 918.13 How the Loss of a Single Hydroxyl Group Affects the Proteolytic Activity of the Model Serine Protease, Trypsin. J. Huang, A.R. Batt, C.P. St. Germain, T. Baird; Jr. San Francisco State University. B170 918.14 Different Phenolic Compounds Selectively Slow Down the Hydrolysis Rates of Sucrose and Isomaltose by Mammalian Mucosal α-Glucosidases. J. Lim, M.G. Ferruzzi, B.R. Hamaker. Purdue University and North Carolina State University.
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BIOCHEMISTRY TUESDAY B171 918.15 Enhancing Efficacy of Protease Drugs Through Site-Directed Mutagenesis. A.N. Amorello, A. Batt, T. Baird; Jr. San Francisco State University. B172 918.16 Chemical Modification of Trypsin Improves Protein Digestion Efficiency. B. Washer, D. Poe, J. O’Grady, K. Meyer. Wabash College and Perfinity Biosciences. B173 918.17 Determining ClpXP Substrates Under Different Nutrient Conditions in Escherichia coli. C. Peterson, A. Mendes, A. Lambert, A. Papaj, P. Ngo, T. Von Rosen. Suffolk University.
919. MULTIENZYME COMPLEXES Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B174 919.1 Overexpression and Characterization of the rqua Gene Product Involved in the Biosynthesis of Rhodoquinone. A. Zander, J. Shepherd. Gonzaga University. B175 919.2 The Structure and Function of Sulfite Reductase Flavoprotein: Three Faces of a Dynamic Enzyme. I. Askenasy, R. Andrews, M. Stroupe. Florida State University. B176 919.3 Characterization of the Nicotinic Acid and 6-Hydroxynicotinic Acid Dehydrogenase Complexes in Bacillus niacini. K.I. Kalafatis, M.J. Snider. The College of Wooster. B177 919.4 Cofactor Analysis of Nicotinate Dehydrogenase and 6-Hydroxynicotinate Dehydrogenase in Bacillus niacini. L.A. Sherer, M.A. Snider, M. Pandelia, R. Rowlett. The College of Wooster, Brandeis University and Colgate University.
920. CYTOCHROME P450 Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B178 920.1 Mechanism and Modulation of Human Androgen Synthesis. R. Duggal, M.C. Gregory, Y. Liu, P.J. Mak, I.G. Denisov, J.R. Kincaid, S.G. Sligar. University of Illinois Urbana-Champaign and Marquette University. B179 920.2 Rolapitant Is Not a Mechanism-Based Inactivator or Tight-Binding Inhibitor of CYP2D6 in Vitro. S. Glass, L.L. Furge. Kalamazoo College. B180 920.3 Molecular Dynamics and Distance-FromAverage-Structure Characteristics of Human Cytochrome CYP2D6. Q.E. Colwell, L. Furge. Kalamazoo College. B181 920.4 Amino Acid Changes in Allelic Variants of CYP2D6 Alter Kinetics and Susceptibility to Inactivation. C.W. Cho, S.M. Glass, V.M. Osorio, K.F. Sunden, R. Fujiwara, L.L. Furge. Kalamazoo College.
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B182 920.5 Cytochrome P450 1B1 (CYP1B1) Knockout Mice Are Less Susceptible to Hyperoxic Pulmonary Injury: A Novel Pro-Oxidant Role for CYP1B1 in Vivo. A. Veith, W. Jiang, L. Wang, G. Zhou, X. Couroucli, K. Lingappan, B. Moorthy. Baylor College of Medicine and Texas A&M University Health Science Center. B183 920.6 Oxidative Inhibition of the ω-Hydroxylation Activity of Cytochrome P450 4A11 by Sulfenylation of the Heme-Thiolate Cysteine. M.E. Albertolle, D. Kim, F.P. Guengerich. Vanderbilt University. B184 920.7 Characterization of Bacterial Cytochrome P450’s Involved in Gibberellin Biosynthesis. R. Nagel, R.J. Peters. Iowa State University. B185 920.8 E3-bglobin-Dd Mice: A New Model to Study Hepatic Zonal Regulation of Sex-Biased Cytochrome P450 mRNA Expression. A.N. Nail, J. Jiang, M.L. Peterson, B.T. Spear. University of Kentucky. B186 920.9 Enzymology of H2S Oxidation in Nanodiscs. A.P. Landry, R. Banerjee. University of Michigan Medical School. B187 920.10 Heterologous Production of Functional Chloroform Reductive Dehalogenase. B. Jugder, K.A. Payne, K. Fisher, M. Manefield, M. Lee, D. Leys, C.P. Marquis. University of New South Wales, Australia and University of Manchester, United Kingdom.
921. ENZYME INHIBITORS AND DRUG DESIGN Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B188 921.1 The Mechanism of Inhibition of Botulinum Neurotoxin Type A by Two Quinolinol Compounds. Y.T. Vroom Teschemaker Minnow, R. Goldberg, S.R. Tummalapalli, D.P. Rotella, N.M. Goodey. Montclair State University. B189 921.2 Expression, Purification, and Characterization of W. bancrofti DHFR and Its Evaluation as a Possible Drug Target for Treating Lymphatic Filariasis. A.M. Tobias, U.A. Gubler, N. Goodey. Montclair State University. B190 921.3 Inhibition of Cholinesterases by β-Carboline Derivatives. J. Soule, W. Horton, S. Peerannawar, N. Kugyela, A. Kulkarni, B. Török, M. Török. University of Massachusetts Boston. B191 921.4 Inhibitory Effects of Substituted Pyrazoline Derivatives on Entamoeba histolytica Alcohol and Acetaldehyde Dehydrogenase (EhADH2) Activities. M. Hackey, L. Rossi, A. Espinosa. Roger Williams University. B192 921.5 ATP Synthase: A Molecular Drug Target for Olive Oil Constituent Tyrosol and Its Analogs. A. Amini, Z. Ahmad. A.T. Still University of Health Sciences—Kirksville College of Osteopathic Medicine. B193 921.6 Understanding the Link Between Antimicrobial Properties of Safranal and Microbial ATP Synthase. M. Liu, Z. Ahmad. A.T. Still University of Health Sciences—Kirksville College of Osteopathic Medicine. B194 921.7 Development of Selective Inhibitor of S-Adenosylmethionine Synthetase in Cryptosporidium parvum. M. Dziobak, G. Parungao, R. Viola. University of Toledo.
TUESDAY BIOCHEMISTRY B195 921.8 Inhibition of Myeloperoxidase by Staphylococcal SPIN Proteins. N.T. Ploscariu, N.W. de Jong, K.X. Ramyar, B.L. Garcia, A.I. Herrera, O. Prakash, P. Haas, J.A. van Strijp, B.V. Geisbrecht. Kansas State University and University Medical Center Utrecht, Netherlands. B196 921.9 Development and Mechanism of SmallMolecule SIRT6 Activators. M. Klein, C. Liu, B. Camacho, W. Tang, J.M. Denu. University of Wisconsin—Madison, University of Wisconsin—Madison and University of Wisconsin -Madison. B197 921.10 Investigation of Possible Inhibitors Against Multidrug-Resistant New Delhi Metallo-Beta Lactamase (NDM1). S.L. Hernandez, S. Shrestha, J. Beckhem, W.L. Fast. University of Texas at Austin. B198 921.11 Novel Inhibitor Targeting ALDOA at Cysteine 289 and the Regulation of Its C-Terminal Tail. G. Stancu, A. Devkota, A. Aleshin, P. De Jong, E. Cho, R. Liddington, G. Powis, K. Dalby. The University of Texas at Austin and Sanford Burnham Prebys Medical Discovery Institute. B199 921.12 Deciphering the Resistance Profile of Cancerous Thymidylate Synthase. Z. Islam, I. Gurevic, M. Saeed, S. Rasool, A. Kohen. The University of Iowa. B200 921.13 A Conserved Ser/Thr Kinase from Malaria Parasites Is Inhibited by Tyrosine Kinase Inhibitors. L. Kirkman, A. Perez, B. Lin, D. Harris, J. Schermerhorn, Y. Qian, G. Brandt. Franklin & Marshall College. B201 921.14 Deciphering the Selectivity and Reactivity of Ebselen Derivatives Toward Mycobacterium tuberculosis Antigen 85C. C.M. Goins, S. Dajnowicz, S. Thanna, S.J. Sucheck, J.M. Parks, D.R. Ronning. University of Toledo and Oak Ridge National Laboratory. B202 921.15 High-Throughput Virtual Screening to Identify Novel Inhibitors of 6-Phosphogluconate Dehydrogenase in Plasmodium vivax. N.B. Weber, C. Trieu, J. Beckham. University of Texas at Austin. B203 921.16 Synthesis of Sphingosine Kinase 1 Inhibitors with Modifications of Zone 2. A. Nemeth, T.C. Grattan. Winthrop University. B204 921.17 Modulation of pTyr Signaling by Small Molecule Inhibitors of SH2-Lipid Interaction. Y. Hu. University of Illinois at Chicago. B205 921.18 Inhibition Studies of Brugia malayi Dihydrofolate Reductase. D. Toska, N. Goodey, U. Gubler. Montclair State University. B206 921.19 Quantification of the in Vitro Inhibitory Effects of the Arachis hypogaea Lectin on HIV-1 Reverse Transcriptase. C.A. Garza, R. Ynalvez. Texas A&M International University. B207 921.20 Identification of Molecular Interactions Within Histone Deacetylase Isozymes for the Development of Selective HDAC2 Inhibitors for the Design of Targeted Cancer Therapies. X. May, D. Watkins, S.V. Stoddard. Rhodes College and University of Mississippi. B208 921.21 Aspartate n-Acetyltransferase: A Key Enzyme in Neurobiology and Cancer. Q. Wang, M. Zhao, G.G. Parungao, B. Thangavelu, V. Mutthamsetty, R.E. Viola. The University of Toledo.
922.
PROTEIN ENGINEERING AND DESIGN Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
B209 922.1 Step-Wise Directed Evolution of an Epoxide Hydrolase Against Progressively Larger Non-Natural Substrates. M. Ko, J.J. Love. San Diego State University. B210 922.2 Prolonged Half-Life of Recombinant Immunotoxins in Mice by Adding an Albumin Binding Domain. M. Onda, I. Pastan. NCI/NIH. B211 922.3 Modular Domain Compatibility Among Cytotoxic Necrotizing Factors—Finding a Universal Platform for BTIDD. E.E. Haywood, M. Ho, B.A. Wilson. University of Illinois at Urbana Champaign. B212 922.4 Development of Phospholipase A2 Receptor Antigen Binding Monobodies for the Inhibition of the Idiopathic Membranous Glomerulonephritis Auto-Antibody Binding. S.V. Stoddard, A. Zaravar, X. May, L. Goldman. Rhodes College. B213 922.5 Improving Personalized Medicine by Examining Structure-Function Patterns in the Non-Conserved Regions of Lactate Dehydrogenase (LDH). E.D. Alao, A. Ayella, M.R. Beck. Wichita State University and McPherson College. B214 922.6 Optimizing a Screen for Incorporating Unnatural Amino Acids Into Bacterial Proteins. S. Dhar, C. Mammoser, A. Gunter, A. Kneusel, G. Burkhart, B. Brown, L. Rowe. Valparaiso University and Ivy Tech. B215 922.7 Modification of Bovine Serum Albumin (BSA) with a Maleimido-Functionalized, 8-Arm Polyethylene Glycol Backbone (Mal-PEG8) as a Drug Delivery System. J. Hill, D. Huskic, J. Parker, R. Carpino, K.W. Olsen. Loyola University Chicago. B216 922.8 In Vitro Development of Synthetic Chromatin Proteins That Function in Live Cells. K.A. Haynes, S. Tekel, D.A. Vargas. Arizona State University. B217 922.9 Using Multivalency to Improve the Function of Synthetic Epigenetic Proteins. S.J. Tekel. Arizona State University. B218 922.10 Engineering a Tunnel to a More Versatile Lipoic Acid Ligase. B. Schmitz, D. Konkolewicz, R.C. Page. Miami University. B219 922.11 Biophysical Characterization and Catalytic Reactivity of Rubrerythrin and Symerythrin Model Proteins. J. Pellegrino, K.A. Bell, R.Z. Polinski, S.N. Cimerol, A. Jacobs, E.I. Solomon, A. Reig. Ursinus College and Stanford University. B220 922.12 Effects of 8-Arm Polyethylene Glycol (PEG8) Addition on Thermal Stability of Bovine Serum Albumin (BSA) J.S. Parker, J. Hill, K.W. Olsen. Loyola University Chicago. B221 922.13 Expression of Keratin in Pichia pastoris for Biopolymer Applications. M.A. Ward, A. Schoepke, L.M. Haverhals, M.R. Fry. Bradley University and National Center for Agricultural Utilization Research. B222 922.14 Rational Design of Epitope Binding Monobodies: New Tools for Autoimmune Therapy. A. Zaravar, X. May, S. Stoddard. Rhodes College. B223 922.15 Engineering a Biocatalyst to Support a Novel Preparation of Blockbuster Statin Drugs. K. Belecki. Virginia Commonwealth University.
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923. PROTEIN-SMALL MOLECULE INTERACTIONS
924. BIOANALYTICAL AND BIOPHYSICAL METHODS
Poster
Poster
Tue. 9:00 am—McCormick Place Convention Center, Hall F
Tue. 9:00 am—McCormick Place Convention Center, Hall F
Presentation time: 12:00 pm–2:30 pm
Presentation time: 12:00 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm
B224 923.1 AF4-AF9 Protein-Protein Interaction Inhibitor: Synthesis and Biological Evaluation. S. Roseman, W. Bao, J. Koh. University of Delaware. B225 923.2 Lafora Disease Premature Termination Codons (PTCs) Are Likely Candidates for Suppression by Aminoglycosides. Z.R. Simmons, A. Sherwood, V. Dukhande, M. Gentry. University of Kentucky. B226 923.3 Discovery and Development of Allosteric Pantothenate Kinase Activators. L. Sharma, C. Subramanian, M. Yun, S. White, S. Jackowski, R.E. Lee, C.O. Rock. St. Jude Children’s Research Hospital. B227 923.4 Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. D. Okafor, S.G. Mays, R.J. Whitby, D. Goswami, J. Stec, A.R. Flynn, M.C. Dugan, N. Jui, P. Griffin, E. Ortlund. Emory University School of Medicine, University of Southampton, United Kingdom, Scripps Research Institute and Emory University. B228 923.5 Trehalose-6-Phosphate Phosphatase Structure and Inhibitor Design. C. Harvey, C. Liu, D. Globisch, K. Janda, D. Dunaway-Mariano, K. Allen. Boston University, University of New Mexico and The Scripps Research Institute. B229 923.6 PA4794 Gcn5-Related N-Acetyltransferase Bisubstrate Inhibitors and Mechanistic Insights from CoCrystal Structures, Site-Directed Mutants, and Molecular Dynamics. C.T. Reidl, K.A. Majorek, J. Dang, M. Law, D. Tran, K. Jew, P. Chiarelli, W. Minor, M. Kuhn, D.P. Becker. Loyola University Chicago, University of Virginia and San Francisco State University (SFSU). B230 923.7 Inhibition of the Herpesvirus Fusion Protein Using Targeted Small Molecules. S.L. Gallagher, H. Deokar, J.K. Buolamwini, S.A. Connolly. DePaul University and Rosalind Franklin University of Medicine and Science.
B231 924.1 Tri-Nucleotide Rolling Circle Amplification: A Novel Method for the Detection of RNA and DNA. J. Zingg, S. Daunert. B232 924.2 Purification and Quantification of the Chemical Markers of Melanin to Enhance Early Diagnosis of Melanoma. C. Weddle, K. Sienerth, K. Glass. Elon University and Duke University. B233 924.3 Supercritical Fluid Chromatography-Tandem Mass Spectrometry Method Development for the Detection of the Rac/Cdc42 Inhibitor MBQ-167 in Mouse Plasma. M. Maldonado, J. Bloom, E. Hernandez-O’Farrill, C. Vlaar, J.F. Rodriguez-Orengo, S. Dharmawardhane. University of Puerto Rico Medical Sciences Campus, School of Pharmacy and University of Puerto Rico. B234 924.4 Genome-Wide Screen for Escherichia coli [NiFe]-Hydrogenase Maturation Factors. M.J. Lacasse, J. Côté, E.D. Brown, D.B. Zamble. University of Toronto, Canada and McMaster University, Canada. B235 924.5 Bead-Based Enzymatic Assay On-A-Chip. S.J. Karnik, S. Cahoon, A. Bhushan. Illinois Institute of Technology. B236 924.6 Investigating Electrostatic Fields at Protein Interfaces for Drug Discovery. L. Strong, E. Novelli, B. Chang, L. Webb. University of Texas. B237 924.7 Droplette—A Fluid Dynamics Driven Platform for Transdermal and Intra-Cellular Delivery of Large Molecules. A. Mahmood, A. Raja, L. Pulakat. Harry S Truman VA Hospital and University of Missouri-Columbia.
925. NANOTECHNOLOGY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B238 925.1 Conductive Gel Polymers as an Extracellular Matrix Mimic and Cell Vehicle for Cardiac Tissue Engineering. M.A. Maldonado, A.J. Bonham. Metropolitan State University of Denver. B239 925.2 Synthesis of Water-Stable Material-Organic Frameworks at Room Temperature. N.H. Le, K. Jackson. Virginia Union University. B240 925.3 Covalent Crosslinking of L-Asparaginase II Subunits by Site-Specific Pegylation. J. Ramirez-Paz, M. Saxena, L.J. Delinois, F.M. Joaquín-Ovalle, V.A. RojasNieves, K. Griebenow. University of Puerto Rico and Rio Piedras.
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TUESDAY BIOCHEMISTRY B241 925.4 Poly(Lactic-Co-Glycolic) Nanoparticles for Biodegradable Chemotherapy Drug Delivery System. B. Liang. St. Mary’s College of Maryland. B242 925.5 Funcionalized Gold Nanoparticles as Potential New Treatment for Acute Myeloid Leukemia. A. Gaiser, S. Hafner, M. Schmiech, T. Syrovets, T. Simmet. Ulm University, Germany. B243 925.6 Effect of an Electric Bias on the Antibacterial Properties of AG-GQD Nanocomposites. N.I. Alvarez-Colon, A. Marra, G. Caro, J. Avalos, G. Morell. University of Puerto Rico Rio Piedras Campus, University of Puerto Rico- Rio Piedras Campus, University of Puerto Rico and Bayamon Campus. B244 925.7 Biomimetic Nano-Patterned Design on the Surface of the Implants to Prevent Bacterial Infections. B. Boucher, M.J. Wolyniak, K.M. Hargadon, R. Dua. HampdenSydney College. B245 925.8 Tracking of Epidermal Growth Factor Receptor in Cancer Cells Using Nanodiamond. Y. Lin. National Chiao Tung University, Taiwan. B246 925.9 Interactions of Rat Embryonic Hippocampal Neuronal Stem Cell on Au-Nanowire Arrays and Gold NanoFilm Surface. A. Islam. Northeastern University. B247 925.10 Phage Templating of Nanoparticles, Proteins, and Biologically Relevant Molecules. S. Prabhu, M. SmithBoeck, P. Santan, N.W. Martinez. Cal Poly State University and San Luis Obispo.
926. PROTEOMICS (II) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Proteomics (I), Monday B248 926.1 Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway. H. Huang, Z. Luo, S. Qi, J. Huang, L. Dai, J. Dai, Y. Zhao. The University of Chicago, Tsinghua University, People’s Republic of China, Sichuan University, People’s Republic of China. B249 926.2 Dissecting the Proteome of Drosophila Hybrids. T.C. Bamberger, M. Montgomery, S. Martínez-Bartolomé, J.R. Yates III. The Scripps Research Institute. B250 926.3 Proteotyping Gene Dosage Effects in Genetic Diseases. Y. Liu, R. Aebersold. Institute of Molecular Systems Biology, ETH Zurich, Switzerland and Faculty of Science, Switzerland. B251 926.4 Phosphoproteins in Extracellular Vesicles as Candidate Markers for Breast Cancer. W.A. Tao, I. Chen, A. Iliuk. Purdue University. B252 926.5 Probing the Global Kinome and Phosphoproteome in Chlamydomonas reinhardtii via Sequential Enrichment and Quantitative Proteomics. E.G. Werth, E.W. McConnell, T.K. Gilbert, I.C. Lianez, C.W. Perez, C. Manley, L.M. Graves, J.G. Umen, L.M. Hicks. University of North Carolina at Chapel Hill and Donald Danforth Plant Science Center.
B253 926.6 Proximity Labeling and Interactomic Study of Primary Cilia. M. Rinschen, P. Kohli, T. Benzing, B. Schermer. University Hospital Cologne, Germany. B254 926.7 Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform. Y. Shi, J. Fernandez-Martinez, S. Kim, U. Paula, R. Pellarin, M. Gagnon, I. Chemmama, J. Wang, I. Nudelman, W. Zhang, R. Williams, W. Rice, D. Strokes, D. Zenklusen, A. Sali, M.P. Rout, B.T. Chait. Rockefeller University, University of Pittsburgh School of Medicine, UCSF, NYU School of Medicine and University of Montreal, Canada. B255 926.8 A High-Throughput Assay Platform for Quantifying Nucleo-Cytoplasmic Phosphatase Activity. M. Shah, S. Kinicki, Z. Chapman, D. Brautigan, K. Janes. University of Virginia. B256 926.9 Analysis of Proteins and Protein Interactions by Size Exclusion Chromatography–High Resolution Mass Spectrometry. F.M. Busch, A. Sahasrabuddhe, Z. vanAernum, B. Rivera, V.H. Wysocki. The Ohio State University and Phenomenex. B257 926.10 Intracellular/Surface Moonlighting Proteins. C. Jeffery, W. Wang. University of Illinois at Chicago. B258 926.11 Mass Spectrometry-Based Salivary Protein Biomarker Discovery in Autism Spectrum Disorder (ASD). K.L. Wormwood, L. Charette, J.P. Ryan, A.G. Woods, C.C. Darie. Clarkson University and SUNY Plattsburgh. B259 926.12 Proteomic Analysis of Hct116 Colon Cancer Cells Treated with Inhibitors That Bind to the N-Terminal Versus the C-Terminal Domain of Hsp90. M. Balch, S.D. Hartson, B.S. Blagg, R.L. Matts. Oklahoma State University and The University of Kansas. B260 926.13 Proteomics Analysis of Human Breast Milk to Assess Breast Cancer Risk. R. Aslebagh, K.F. Arcaro, C.C. Darie. Clarkson University and University of Massachusetts Amherst. B261 926.14 Translational Top Down Proteomics of KRASDriven Cancers and Models Thereof. I. Ntai, L. Fornelli, J. Hutton, R. LeDuc, R. Fellers, N. Haverland, P. Compton, G. Whiteley, E. Boja, H. Rodriguez, N. Kelleher. Northwestern University, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Office of Cancer Clinical Proteomics Research and National Cancer Institute. B262 926.15 Bradykinin Mediates the Secretion of Coagulation Factor VIII by Mouse Dendritic Cells via Bradykinin 2 Receptor (B2R) Activation. C.C. Clement, A. Follenzi. Albert Einstein Coll Med CUNY, University of Piemonte Orientale and School of Medicine, Italy. B263 926.16 Proteomics and Functional Genomics of the D. grimshawii Sperm and Associated Male Reproductive Tract Tissues. T. Karr, J. Oses, A. Burlingame, B. Oliver. Kyoto Institute of Technology, Japan, UC San Francisco and NIH. B264 926.17 Mass Spectrometric Approaches Toward SiteSpecific Characterization of the ADP-Ribosylated Proteome. Y. Yu. UT Southwestern Medical Center.
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927. SYSTEMS BIOLOGY AND REGULATORY NETWORKS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B265 927.1 Dissection of Z-Disc Myopalladin Gene Network Involved in the Development of Restrictive Cardiomyopathy Using System Genetics Approach. L. Lu, Q. Gu, U. Mendsaikhan, Z. Khuchua, B. Jones, J. Towbin, E. Purevjav. University of Tennessee Health Science Center, Cincinnati Children’s Hospital Medical Center, Mongolian National University of Medical Sciences, Mongolia, Le Bonheur Children’s Hospital and St. Jude Children’s Research Hospital. B266 927.2 Temporal Analysis of Coagulopathy in Burn Sepsis Using a Systems Biology Approach. S. Srinivasan, D. Donohue, A. Gautam, L. Detwiler, M.M. McLawhorn, S. Tejiram, L.T. Moffatt, M. Jett, J.W. Shupp, R. Hammamieh. The Geneva Foundation, USACEHR, MedStar Health Research Institute and MedStar Washington Hospital Center. B267 927.3 Altered Fecal Microbiota and Urine Metabolites Following Soman Exposure in a Rat Model. A. Gautam, D. Getnet, R. Kumar, A. Hoke, A.K. Cheema, F. Rossetti, C. Schultz, R. Hammamieh, L.A. Lumley, M. Jett. US Army Center for Environmental Health Research, Advanced Biomedical Computing Center, Frederick National Lab for Cancer Research, The Geneva Foundation, USACEHR, Georgetown University, Clinical Research Management, Edmond Scientific Company and US Army Medical Research Institute of Chemical Defense. B268 927.4 HeteroPath: A Pathway-Based Computational Modeling Approach to Identify Tissue-Specific Gene Expression Networks. A. Jambusaria, J. Klomp, Z. Hong, S. Rafii, A.B. Malik, J. Rehman. University of Illinois at Chicago and Cornell University. B269 927.5 Efficient Automatic Induction of Rules in Biological Systems. M.E. Whiting, P.R. Leduc, J. Cagan. Carnegie Mellon University. B270 927.6 Characterizing the Functions of Structural Genomics Proteins Through Computed Chemical Properties and Experimental Chemistry. C.L. Mills, P.J. Beuning, M. Ondrechen. Northeastern University. B271 927.7 Prediction of β-Lactamase Proteins Using Random Forest. C. White, D. KC. North Carolina A&T State University.
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928. CELL STRESS AND XENOBIOTICS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B272 928.1 Determining the Effects of Intracellular pH on the Translational Response to Heat Shock. C.G. Triandafillou, A.R. Dinner, D. Drummond. University of Chicago. B273 928.2 Metabolic Mediation of Antifungal Toxicity. D. Cabral, P. Belenky. Brown University. B274 928.3 Effect of Thermal Manipulation During Broiler Chicken Embryogenesis on the Differential Expression of Heat Shock Protein and Factor During Heat Stress on Post-Hatch Chicken. M.B. Alzghoul. Jordan University of Science and Technology, Jordan. B275 928.4 Activity of Hepatic Expression of Glutathione S-Transferase Isotypes (Alpha, Pi, and Mu) of Mus musculus Exposed to Atrazine in Utero. L. Finley. Saint Mary’s University of Minnesota. B276 928.5 Cytotoxicity of Urban Dust and Diesel Exhaust Particulates in Murine Astrocyte Cells. T.R. Fortuna, P.C. Price, K.J. Lopez, A.J. Schwader, P. Mazzer. Dakota Wesleyan University. B277 928.6 Cloning and Protein Overexpression of Chlamydomonas reinhardtii’s Novel Gene Cia7. H. Gonzalez-Cantu, E. Vazquez, R. Ynalvez. Texas A&M International University. B278 928.7 Annotating the CIA7 Gene: Comparing Lead Bioaccumulation, Cell Growth and Morphology in Two Strains of Chlamydomonas reinhardtii. J.A. Gutierrez, R. Ynalvez. Texas A&M International University.
929. SIGNALING INTEGRATION AND CROSS-REGULATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B279 929.1 Design Principles of Pleiotropic G-Protein Signaling Through Guanine Nucleotide Exchange Modulators (GEMs). P. Rangamani, M. Getz, P. Ghosh. UCSD. B280 929.2 Glucocorticoid-Induced Inhibition of AKT Leads to CREB Phosphorylation and Increased Myostatin Expression via a PDE/cAMP/PKA Pathway in Skeletal Muscle. Y. Xie, P. Zhang, D. Espinoza, B. Perry, J. Rahnert, B. Zheng, R. Price. Emory University, Xiangya Hospital and Xiangya School of Medicine, Central South University, People’s Republic of China. B281 929.3 Withdrawn.
TUESDAY BIOCHEMISTRY B282 929.4 Shoc2 Mediates Hematopoietic Signals of the ERK1/2 Pathway. H. Jang, E. Jang, A. Morris, M. ForbesOsborne, E. Galperin. University of Kentucky. B283 929.5 Identification of a Novel Pathomechanism Underlying a Congenital Disorder of Glycosylation: Crosstalk Between Hexosamine Biosynthetic Pathway, PI3K/AKT Signaling, and Protein Glycosylation. S.Y. Wong, S. Perez, X. Huang, K. Stiers, L. Beamer, F. Foulquier, G. Berry, T. Kozicz, E. Morava. Tulane University School of Medicine, Boston Children’s Hospital, University of Missouri and University of Lille 1, France.
930. SPATIOTEMPORAL CONTROL OF SIGNALING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B284 930.1 The (AAA+) ATPases PSMC5 and VCP/ p97 Control ERK1/2 Signals Transmitted Through the Shoc2 Scaffolding Complex. E. Galperin, E. Jang, D. Anderson, H. Jang. University of Kentucky and Cleave Bioscience. B285 930.2 Mating Yeast Cells Concentrate the Pheromone Receptor and Its G Protein as Polarized Crescents at the Default Polarity Site That Then Track to the Eventual Chemotropic Site. X. Wang, D.E. Stone. University of Illinois at Chicago. B286 930.3 ERK1/2 Signaling Through Scaffold Protein Shoc2 Complexing with H, K, and M-Ras: A Structure-Function Analysis. R. Norcross, E. Galperin. University of Kentucky. B287 930.4 DUOX1 Silencing in Lung Cancer Is Associated with Enhanced Nuclear EGFR Localization. A. Little, K. Danyal, D. Heppner, M. Hristova, A. van der Vliet. University of Vermont. B288 930.5 The Role of Diacylglycerol and Cysteine-Rich Domains in Spatiotemporal Regulation of Protein Kinase D1 in Cardiac Myocytes. B.M. Wood, M. Ferrero, L.J. Gilardoni, M.F. Goldman, J. Bossuyt. UC Davis. B289 930.6 Characterizing the Role of Yeast Cyclin Pcl1 in the Establishment of Pheromone Receptor Polarity. C Y. Pai, M. Sukumar, D. Stone. University of Illinois at Chicago.
931. CELL MOTILITY AND MIGRATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F
B291 931.2 Galectin-1 Modulates Focal Adhesion Turnover and Migration of Vascular Smooth Muscle Cells. L. Chau, M. Chiang, D. Tsai, M. Tsai. Institute of Biomedical Sciences and Academia Sinica, Taiwan. B292 931.3 Serglycin Regulates Cytoskeletal-Related Proteins Associated with Cell Motility in Breast Cancer in Vitro. B. Bay, P. Chua, G.W. Yip, J. Gunaratne. National University of Singapore, Singapore and Institute of Molecular and Cell Biology, Singapore. B293 931.4 Characterization of the Cask Protein in Drosophila Ovaries. S. VanHorn, C. Wirth, T. Hoffman, J. Sanner, C. Warren, S. Liber, M. Popil, D. Miller, S. Maraugha, J.L. Sanford. Ohio Northern University. B294 931.5 Generation of a CASK-GFP Transgenic Fly Line. J. Sanner, C. Lovejoy, K. Robinson, E. Olah, J.L. Sanford. Ohio Northern University.
932. CHECKPOINT MECHANISMS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B295 932.1 The Response of Histone H3.3 to Chromosomal Misalignment and Missegregation: A Novel Biochemical Pathway Correlated to Cell Cycle Arrest. S. Fadness, C.A. Day, A. Langfald, E.H. Hinchcliffe. Hamline University, The Hormel Institute and University of Minnesota. B296 932.2 The ULK3 Kinase Regulates the ESCRT Pathway in the Abscission Checkpoint. D.M. Wenzel, J. McCullough, A. Caballe, J. Marin-Serrano, W.I. Sundquist. University of Utah and King’s College London, United Kingdom. B297 932.3 Functional Characterization of a Novel Role for Rfa2 N-Terminal Hyper-Phosphorylation During Checkpoint Adaptation. T.M. Wilson, T.A. Baumgartner, B.L. Senger, N.M. Miles, S.J. Haring. North Dakota State University. B298 932.4 Phosphorylation of Replication Factor a Promotes Checkpoint Adaptation in Adaptation-Deficient Phosphatase Deletion Strains. T.A. Baumgartner, S.J. Haring. North Dakota State University. B299 932.5 Phosphorylated Astrin Regulated Kinetochore Function Mediated by TRAIP in Mitosis. H. Chung, J. Park, J. Lee, H. Kim. Sungkyunkwan University, Republic of Korea, and Sookmyung Women’s University, Republic of Korea. B300 932.6 Regulation of Mitotic Microtubule Dynamic Instability in Monopolar Spindles by Bundling and Kinetochore Attachment. Z.R. Gergely, P.J. Flynn, S. Montes, J. McIntosh, M. Betterton. University of Colorado at Boulder.
Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B290 931.1 Ubiquitin-Like Protein Ubl4a Promotes ActinMediated Cell Migration. H. Zhang, Y. Zhao, C.R. Affonso, A. Manas, R. Bonomo, J. Xiang. Illinois Institute of Technology.
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933. BIOCHEMISTRY OF SIGNALING, CANCER, AND AGING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B301 933.1 Calcineurin Homologous Protein Expression Regulates Na+/H+ Exchanger 1 Dependent Tumor Survival. W.T. Cottle, M.A. Wallert, J.J. Provost. University of San Diego and Bemidji State University. B302 933.2 PDEF Induce Luminal Differentiation in Metastatic Prostate Cancer Cells. F. Wang, S. Koul, P. Timiri Shanmugam, Q. Dong, H.K. Koul. Louisiana State University Health Sciences Center-Shreveport, Overton Brooks VA Medical Center and Feist Weiller Cancer Center. B303 933.3 Novel Protein Interactions Provide Insight Into the Regulation of the Polymerase Associated Factor Complex in Acute Myeloid Leukemia. J. Ropa, J. Serio, L. Chen, W. Chen, M. Mysliwski, D. Mellacheruvu, V. Basrur, A. Nesvizhskii, A. Muntean. University of Michigan. B304 933.4 Polyphenon E Alters P53 and P73 Gene Expression. R.A. Cordova, L. Carastro, D.E. Barboto, R.A. Declet-Bauzo, Z.M. Conelly, J.Y. Park. The University of Tampa, Universidad Central del Caribe and H. Lee Moffitt Cancer Center & Research Institute. B305 933.5 Dissecting the TORC1 Gene Interaction Network by Perturbing Different Subunits. C.J. Torres Gutierrez, S.M. Santos, J.L. Hartman. University of Puerto Rico at Ponce, Puerto Rico and University of Alabama at Birmingham. B306 933.6 Arsenic and Line-1 Disrupt Developmental Epithelial to Mesenchymal Transition: Implications for Cardiac Morphogenesis. A.B. Perrera, T. Huang, P. Bojang, M. TaveraGarcia, E.M. Reyes-Reyes, K.S. Ramos, T.D. Camenisch. University of Arizona. B307 933.7 The Role of CDKN3 in Neuroblastoma Differentiation. V. Partridge, L. Du. Texas State University.
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934. CANCER SIGNALING AND THERAPEUTICS (II) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Cancer Signaling and Therapeutics (I), Monday B308 934.1 Electrophilic Nitro-Oleic Acid Inhibits Triple Negative Breast Cancer Cell Migration via Suppression of NF-κB Activity. C. Woodcock, S. Woodcock, S. Salvatore, N. Davidson, Y. Huang, B. Freeman. University of Pittsburgh and University of Pittsburgh Cancer Institute. B309 934.2 Sensitizing Pancreatic Cancer Cells to Chemotherapeutics by Modulating Intracellular Iron Homeostasis. K.D. Bilyeu, C. Li. University of Louisville. B310 934.3 Individualized Proteogenomics in Analysis of Resistance to BRAF Inhibition in Malignant Melanoma. M. Schmitt, N. Nalpas, A. Maass, B. Macek. University of Tuebingen, Germany. B311 934.4 Kv3.1 and Kv3.4 as Tumor Hypoxia Related Voltage-Gated Potassium Channels. M. Song, S. Park, J. Park, J. Byun, H. Jin, S. Seo, P. Ryu, S. Lee. Seoul National University, Republic of Korea. B312 934.5 TG-Interacting Factor Can Elicit Hedgehog Pathway to Increase Resistance to Gemcitabine in Urothelial Carcinoma. H. Huang, Y. Huang. Department of Medical Laboratory Science and Biotechnology, College of Medicine and National Cheng Kung University, Taiwan. B313 934.6 Sequence-Dependent Sorafenib Therapy in Combination with Natural Phenolic Compounds for Hepatocellular Carcinoma and Possible Mechanism of Action. M. Abaza, A.M. Bahman, S. Khoushiash, R. Al-Attiyah. Kuwait University, Kuwait. B314 934.7 The Potential Role of NMDA Receptor Regulating TGF-β/Smad Pathway in Radiation-Induced Resistance in Glioblastoma Multiforme. C. Liu, S. Wu, C. Sze. The Institution of Basic Medical Science, National Cheng Kung University, Taiwan, Department of Physiology, National Cheng Kung University, Taiwan, Department of Cell Biology and Anatomy and National Cheng Kung University, Taiwan. B315 934.8 The Chemosensory Bitter Taste Receptors (T2Rs) Are Involved in Proliferation and Migration of Breast Cancer. N. Singh, F. Shaik, R.P. Bhullar, P. Chelikani. University of Manitoba, Canada. B316 934.9 Holographic View of the Senescent Cells: Imagine All the Senescent Cells Are Not Flattened. Y.D. Şimay, A. Özdemir, B. İbiŞoĞlu, M. Ark. Gazi University, Turkey. B317 934.10 Anticancer Activity of Novel Benzimidazole Derivatives Against MCF-7 Cancer Cells. A. Özdemir, S. Uzunoğlu, B. Çalışkan, E. Banoğlu, M. Ark. Gazi University, Turkey.
TUESDAY BIOCHEMISTRY B318 934.11 Puringeric Signaling in Bone as a Potential Mechanism in Prostate Cancer Proliferation and CancerInduced Bone Pain. M. Wilson, R. Duncan, M. Boggs. University of Delaware. B319 934.12 Exploiting Immunogenic Modulation in Chordoma: Sublethal Radiation Increases EGFR Expression and Sensitizes Tumor Cells to Cetuximab. J. Griner, M. Padget, J. Hodge. Florida Southern College, National Cancer Institute and National Institutes of Health. B320 934.13 Connections Between NF-κB Misregulation and Carcinogenesis. T. Link, D. Chyong, A. Naderi, C. Lee, T. Arpornsuksant, A. Lu, M. Dilip, M. Zhang. Walton High School. B321 934.14 3,4’,7-O-Trimethylquercetin as a Novel Agent to Inhibit in Vitro Ovarian Cancer Cell Migration and Invasion. K. Yamauchi, S.H. Afroze, D.M. Dean, T. Mitsunaga, D.C. Zawieja, M.N. Uddin. Gifu University, Japan, Texas A&M Health Science Center College of Medicine and Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine. B322 934.15 Hypoxia and Serum-Deprivation Impacts Calcineurin B Homologous Protein Isoform 2 Expression and Activity in Non-Small Cell Lung Cancer. C.H. Wallert, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B323 934.16 The Role of the Na+-H+ Exchanger Isoform 1 (NHE1) and Calcineurin B Homologous Protein Isoform 2 (CHP2) on Cell Proliferation and Migration in Squamous Cell Carcinoma of the Lung. A.J. Kooiker, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B324 934.17 Characterizing the Role of the Na+-H+ Exchanger Isoform 1 (NHE1) in Cell Proliferation and Migration in Ovarian Cancer Cells. T.M. Manzella, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B325 934.18 Targeting Integrin-Linked Kinase with SmallInterfering RNA Suppresses Invasion and Metastasis in Cisplatin-Resistant Ovarian Cancer. J.M. Reyes-González, P. Báez, F. Valiyeva, P.E. Vivas-Mejía. University of Puerto Rico, Medical Sciences Campus, Comprehensive Cancer Center, University of Puerto Rico and Comprehensive Cancer Center. B326 934.19 Role of Bcl-2 in Hematological Cancer Formation. T. Link, A. Fortier, S. Jain, A. Kepner, A. Koh, L. Stanovski, M. Ul-Islam, E. Walter. Walton High School. B327 934.20 Cinobufotalin Inhibits Ovarian Cancer Cell Metastasis via Apoptotic Signaling and Targeting the mTOR Pathway. S.H. Afroze, C. Peddaboina, D.M. Dean, A. McDowell, T.C. McCormick, K. Newell-Rogers, D.C. Zawieja, T.J. Kuehl, M.N. Uddin. Texas A&M Health Science Center College of Medicine and Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine. B328 934.21 Evaluation of the High Mobility Group A1 Proteins (HMGA1) as a Key Mediate in the Anticancer Activity of EF24. M.N. Diaz, L. Travis, S. Barber, T.F. Sumter. Winthrop University.
B329 934.22 A Novel Endoglin Variant in Pancreatic Ductal Adenocarcinoma. S. Kumar, N. Shah, N. Zaman, N.Y. Lee. The Ohio State University Columbus, Ohio and The Ohio State University Columbus OHIO. B330 934.23 Role of Autophagy in Temozolomide-Induced Apoptosis in Rhabdomyosarcoma Cells. A. Rezaeimoghadam, J. Alizadeh, J. Field, S. da Silva Rosa, J.W. Gordon, S. Ghavami. University of Manitoba. B331 934.24 Effects of Charged Resveratrol Derivatives on Ca2+ Homeostasis in Human Cancer Cells. J.A. Peterson, J.P. Hastings, J.D. Kenealey. Brigham Young University. B332 934.25 Salicylates Promote ROS-Induced Endoplasmic Reticulum Stress Triggering Apoptosis on B16F10 Melanoma. P. Ausina, J.M. Albanese, J.B. Leandro, A.M. Mendonça, F. Palhano, D. Foguel, M.F. Oliveira, P. Zancan, M. Sola-Penna. Universidade Federal do Rio de Janeiro, Brazil. B333 934.26 Inhibition of microRNA-17 Promotes the Progression of Thyroid Cancer in a Xenograft Murine Cancer Model. Y. Yan, S. Eliason, R. Ries, L. Hong, H. Cao, B.A. Amendt. University of Iowa, Craniofacial Anomalies Research Center, Carver College of Medicine and Iowa Institute for Oral Health Research. B334 934.27 Synthesis of a Mini-Reporter Construct to Test Gene Transfer of RNA Therapeutics. K. Muralidharan, A.M. Khan, K. Fuoco, H. Patel, M.J. Hicks. Monmouth University. B335 934.28 Characterizing the Specificity of E3 Ubiquitin Ligase MARCH1 for CD98. S.S. Najera, J. Ablack, M. Ginsberg. San Diego State University, University of California at San Diego.
935. MECHANISMS OF AGING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B336 935.1 An Ageless Wonder: Decreasing Cardiac CapZ Prevents Myocardial Decline in Aged Mice. W.G. Pyle, I. Lorenzen-Schmidt, C.J. Reitz, F.J. Alibhai, T.A. Martino. University of Guelph, Canada. B337 935.2 Analysis of Telomere Length in Aging and AgeRelated Illness. S.M. Connon, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. B338 935.3 Follicle Stimulating Hormone and Reproductive Aging. A. Pardue, I. Dvoretz, C. Wright, A. Custard, E. Barbara, D. Langat. Olathe North High School. B339 935.4 The Role of the Sphingolipid Metabolism Pathway in Healthy Aging. H.P. Hrobuchak, A.P. Ardasheva, D.P. Servello, A.P. Nolan, J.P. Chan. Juniata College.
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936. NEUROBIOLOGY AND NEURONAL SIGNALING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B340 936.1 Comparative Study of the Response to Light on the Sensory Motor Integration of Gill Lateral Cell Cilia in Bivalve Mollusc. D. Semple, J. Jean-Pierre, M.A. Carroll, E.J. Catapane. Medgar Evers College. B341 936.2 Immunohistofluorescence Localization of Biogenic Amine Receptors in Ganglia and Tissues of the Bivalve Mollusc, Mytilus edulis. D. Cummings, M. Jacobs, M.A. Carroll, E.J. Catapane. B342 936.3 Coordinated Beating of Gill Lateral Cell Cilia of Mytilus edulis and Crassostrea virginica Involves Neuronal Innervation and Functioning Gap Junctions. R. Buchanan, C. Robertson, D. Frank, E.J. Catapane, M.A. Carroll. B343 936.4 High-Throughput Functional Annotation of the Caenorhabditis elegans Neural Network. W. Aoki, H. Yokoyama, H. Matsukura, M. Ueda. Kyoto University, Japan, JST, PRESTO, Japan, JST and PRESTO, Japan. B344 936.5 Neural Stem Cells Promote Nerve Regeneration Through IL12-Induced Schwann Cell Differentiation. I. Chiu, D. Lee, J. Chen. National Health Research Institutes, Taiwan. B345 936.6 Attenuation of Glia Maturation Factor Enhances Mitochondrial Biogenesis, Decreases Oxidative Stress and Apoptotic Cell Death in N27 Dopaminergic Neurons. G.P. Selvakumar, D. Kempuraj, R. Thangavel, M.E. Ahmed, S. Zaheer, S.S. Iyer, A. Zaheer. University of Missouri and HSTM Veterans Hospital. B346 936.7 The Role of Rho/ROCK Pathway on the Sacral Neural Crest Cell Migration in the Mouse Gut. X. Zhang, W. Chan. School of Biomedical Sciences, Faculty of Medicine and The Chinese University of Hong Kong, Hong Kong. B347 936.8 Potential Mechanisms of the Antidepressant Effects of FGF2: Gene Expression Changes in Postmitotic Human Excitatory Neurons. S. Gupta, T. Redmond, F. Meng, M. Uhler. University of Michigan. B348 936.9 Molecular Cloning of a Novel 69 kDa BrainSpecific Isoform of Regulator of G Protein Signaling 6 (RGS6). K.E. Ahlers, A. Stewart, J. Yang, J.G. Koland, R.A. Fisher. University of Iowa and Florida Atlantic University. B349 936.10 Optogenetic Stimulation of BLA Cholinergic Terminals Induces a Hypophagic Phenotype. A.P. Addison, J. Ortiz-Guzman, B.R. Arenkiel. University of St. Thomas, Baylor College of Medicine and Jan & Dan Duncan Neurological Research Institute. B350 936.11 PRn Poly-Dipeptides Encoded by the Repeat Expansion in C9orf72 Block Nuclear Import and Export. K. Shi. UT Southwestern. B351 936.12 The Role of Neurotropism in HIV-1 gp120 Induced Oxidative Stress and Neurodegeneration. L. Smith, K. Walsh, L. Whittington, A. Shaw, L. Minamide, K. Watson, G. Cartagena, J. Bamburg, T. Kuhn. University of Alaska Fairbanks and Colorado State University.
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B352 936.13 Identifying the Expression Patterns of xCT in Zebrafish to Determine Its Role in Neuroregeneration. M.A. Solorzano, N.A. Ladd, K.C. Franz, C.O. Da Silva, S.M. Degnan, L.A. Chase, A.P. Putzke, B.P. Krueger. Hope College and Whitworth University. B353 936.14 Measuring Nestin Expression in RA-BDNF Differentiated SH-SY5Y Human Neuroblastoma Cells by Flow Cytometry. J. Graham, T. Laakko Train. Elon University. B354 936.15 Elucidating the Reproductome: System-Wide Regulation of Reproductive Neuropeptides. M. Glucksman, K. Philibert, N. Woitowich, J. Urban, G. DeJoseph. Chicago Medical School and Northwestern University. B355 936.16 Novel Role of bHLH Proteins in Synaptogenesis: Class I bHLH Proteins TCF4 and Daughterless Restrict Synaptic Branching and Bouton Formation via Neurexin Repression in Postmitotic Neurons. E.L. Robinson, E.A. Waddell, M. D’Rozario, D.R. Marenda. Drexel University, Washington University School of Medicine and Drexel University College of Medicine. B356 936.17 An Artistic Approach for Purification of AdenoAssociated Virus and Adenovirus. D. He, M. Xie. C&M Biolabs.
937. IMMUNITY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B357 937.1 Prion-Like Protein Polymerisation Underlies Signal Transduction in Innate Immunity: The Emergence of a Universal Mechanism? A. O’Carroll, T. Ve, M. Moustaqil, N. Giles, A. Bhumkar, D. Hunter, B. Kobe, E. Sierecki, Y. Gambin. UNSW (University of New South Wales), Australia and UQ (University of Queensland), Australia. B358 937.2 Novel Mechanism That Regulates Innate Immunity. A. Frolov, C. Csepeggi, L. Yang, M. Jiang, E. Cook, L.J. Crofford. Saint Louis University, University of Cincinnati, University of Kentucky and Vanderbilt University. B359 937.3 Investigating Structural Drivers of Antigen Specificity. N.K. Singh, S. Smith, D. Harris, D. Kranz, B.M. Baker. University of Notre Dame and University of IllinoisUrbana Champagne. B360 937.4 Detecting Pal Lipoprotein in Gram-Negative Sepsis Patients. K. Farquharson, B. Novick, E. Snyder, M. Pichichero, J. Hellman, L. Michel. Rochester Institute of Technology, Rochester General Hospital, University of California at San Francisco. B361 937.5 Elucidating the Effects of Antibiotics on the Release of Pal from Escherichia coli and P6 from Nontypeable Haemophilus influenzae. N. Fernandez, C. McNamara, M. Pichichero, J. Hellman, L. Michel. Rochester Institute of Technology, Rochester General Hospital, University of California at San Francisco. B362 937.6 Effect of ZNT7 on the CD40 Signaling Pathway in B Lymphocytes: A Possible Mechanism for a Regulatory Role of Zinc in Immune Function. L. Huang, S. Tepaamorndech, P. Oort, C.P. Kirschke, Y. Cai. University of California, Davis, USDA/ARS/Western Human Nutrition Research Center and National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand.
TUESDAY BIOCHEMISTRY B363 937.7 Protection from Influenza a Virus Infection by Modulating Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Signaling. K.M. Wiese, C.M. Koch, B. Coates, K.M. Ridge. Northwestern University. B364 937.8 The Effects of Thapsigargin and Concanavalin a on Jurkat T-Cell Interleukin-2 (IL-2) Production: A Preliminary Study. R.M. Lee, W. Jones. Viterbo University. B365 937.9 HIV-1 gp120JRFL Mediated Human α7 nAChR’s Up-Regulation and Its Implications in the Cholinergic AntiInflammatory Response (CAP). S. Cotto, J.O. Colon, O. Quesada, J.A. Lasalde. University of Puerto Rico, Puerto Rico, UPR Medical Sciences Campus, Puerto Rico and UPR Rio Piedras, Puerto Rico. B366 937.10 YKL40: A Key Modulator of the CF Inflammatory Response? G.F. Bouvet, O. Bulka, A. Coriati, C. Massé, Y. Berthiaume. IRCM, Canada. B367 937.11 Recombinant Adenoviral Vaccine Carrying the S1 Subunit of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Gene Can Elicit Cellular Immune Response in Mice. M. Ababneh. Jordan University of Science and Technology, Jordan.
938. TARGETED THERAPIES AND NEW TARGETS FOR DRUG DISCOVERY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B368 938.1 Lentivirus-Mediated RNA Interference Knockdown of Inositol Requiring 1 Enhances Sorafenib Lethality in Hepatoma Hep3B Cells Involving Autophagy Inhibition. Y. Hu, H. Ye, G. Zhang, L. He, Z. Liu, L. Chen. The People’s Hospital of Guangxi Zhuang Autonomous Region, People’s Republic of China, Guangxi Medical University, People’s Republic of China, First Affiliated Hospital of Guangxi Medical University, People’s Republic of China. B369 938.2 Muscle Growth by Activin Type II Receptor Blocking Ameliorates Weakness in GNE Myopathy Mice. S. Noguchi, T. Yonekawa, M.V. Malicdan, M. Miyakawa, E. Lach-Trifilieff, I. Nonaka, I. Nishino. National Institute of Neuroscience, NCNP, Japan, National Human Genome Research Institute, National Institutes of Health and Novartis Institutes for Biomedical Research, Switzerland. B370 938.3 The Tyrosine Phosphatase PRL3 Drives T-Cell Acute Lymphoblastic Leukemia Progression. R.E. Sieg, S. Lammers, S. Hausman, J. Blackburn. B371 938.4 A Time Course Analysis of the Effects of Arachidin 1 and Arachidin 3 on a Rotavirus-Infected Human Intestinal Cell Line. C.M. Witcher, H.N. Lockwood, R. Napier-Jameson, M.N. Mattila, E.B. Strange, J. Taylor, B. Clack, F. Medina-Bolivar, J.M. Ball. Stephen F Austin State University, Arkansas State University and Texas A&M University Commerce. B372 938.5 Inulin Acetate Nanoparticles as Vaccine Adjuvants. S. Narisetty. Kalamazoo College.
B373 938.6 Peptide B7-33, a Single-Chain Derivative of the Relaxin Hormone Protects Cytotrophoblasts from Marinobufagenin-Induced Preeclampsia Phenotype. A.F. Pantho, S.H. Afroze, D.M. Dean, M.A. Hossain, R. Bathgate, S. Xia, D.C. Zawieja, T.J. Kuehl, M.N. Uddin. University of Texas at Austin, Texas A&M Health Science Center College of Medicine, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, University of Melbourne, Australia and Boster Biological Technology. B374 938.7 Characterization of Asialoglycoprotein Receptor (ASGPR) Directed Hepatocellular Delivery Using a Pfizer Developed Targeting Ligand PF-06853291. M. Roy, J. Finley, T. Coskran, A. Shen, S. Xia, B. Thuma, V. Mascitti. Pfizer, Groton, CT. B375 938.8 Use of Novel Drug Carrier System to Selectively Deliver Rolipram to the Liver for the Treatment of Alcoholic Liver Disease. W. Rodriguez-Alvarez, J. Zhang, G. Perez-Abadia, C. McClain, S. Barve, C. Maldonado, L. Gobejishvili. University of Louisville. B376 938.9 Targeting the Transcriptional Kinases CDK12 and CDK13 in Breast and Ovarian Cancer. K. Hamman, M. Bradley, J. Marineau, Y. Choi, G. Malojcic, D. Orlando, Y. Ren, N. Ke, S. Hu, E. Olson, C. Fritz, C. Roberts. Syros Pharmaceuticals. B377 938.10 TRPM7 Kinase Domain Rather Than the Channel Regulates Breast Cancer Cell Migration and Tumor Metastasis. T.S. Kaoud, X. Xie, R.A. Mangieri, J. Park, C.D. Tavares, N.D. Ebelt, M. Cano, S.V. Ravenstein, S. Mitra, M.F. Radwan, R.A. Morrisett, C. Bartholomeusz, K.N. Dalby. The University of Texas at Austin, MD Anderson Cancer Center, Harvard Medical School, King Abdulaziz University, Saudi Arabia.
939. ANTIBACTERIAL TARGETS AND DRUG DISCOVERY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B378 939.1 The Development of Novel Small Molecule Inhibitors of Listeria monocytogenes and Staphylococcus aureus Pyruvate Carboxylase. B.N. Wyatt, S. Matloub, M. St. Maurice. Marquette University. B379 939.2 Unravelling the Myths and Mysteries of the Antimicrobial Agent, Silver. J. Lemire, K. Chatfield-Reed, L. Kalan, N. Gugala, C. Westersund, H. Almblad, G. Chua, R.J. Turner. The University of Calgary, Canada and Perelman School of Medicine. B380 939.3 Aral Phosphatase from Bacillus subtilis, a Member of the HAD Superfamily. C. Martin, J. Armeli, M. Madaio, J. Hill, S. O’Handley. Rochester Institute of Technology. B381 939.4 Exploring Inhibitors of the Periplasmic Chaperone SurA Using Fluorescence Anisotropy. E.J. Zheng, E.W. Bell, L.M. Ryno. Oberlin College. B382 939.5 Targeting Sigma Factor Controlled Signaling Pathways to Modulate Biofilm Growth and Composition. L.M. Ryno, E.R. Brezel, S.J. Loewus, E.J. Zheng. Oberlin College.
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BIOCHEMISTRY TUESDAY B383 939.6 Diadenosine Polyphosphatases of the NUDIX Hydrolase Superfamily in M. tuberculosis. A.M. DiCola, A. Knowles, S. O’Handley. Rochester Institute of Technology. B384 939.7 Suppression of Biofilm Formation in Staphylococcus aureus by Targeting Staphylococcal Accessory Regulator X Expression Using siHybrids. M. Morrow. Westminster College. B385 939.8 Discovery of Antibiotic Peptides from NoveltyPrioritized Natural Product Genome Mining. C.J. Schwalen, D. Mitchell. University of Illinois at Urbana-Champaign. B386 939.9 Small-Molecule Inhibitors Against Type 1 Pili Selectively Target Uropathogenic E. coli in the Gut and Bladder. C.N. Spaulding, A.L. Kau, R.D. Klein, J.W. Janetka, J.I. Gordon, S.J. Hultgren. Washington University in St. Louis. B387 939.10 Synthesis of Potential AAC(6′)-Ib Inhibitors to Combat Bacterial Resistance to Aminoglycoside Antibiotics. M. Simes, K.J. Labby, K. Johnson. Beloit College. B388 939.11 Phagosomal Copper Triggers a Peptidomimetic’s Oxidative Activity and Enables Eradication of Intracellular Mycobacterium tuberculosis. M.J. Libardo, K. Anand, G. Krishnamoorthy, S.H. Kaufmann, A. Singh, A. Angeles-Boza. University of Connecticut, Indian Institute of Science, India and Max Planck Institute for Infection Biology, Germany. B389 939.12 Targeting Resistant Bacterial Pathogens with Next Generation Antifolates. D. Wright. University of Connecticut. B390 939.13 The Antimicrobial Properties of Extracts Isolated from Lichen Parmelia Vagans. V. Bondarenko, M. Korczynski, W. Techathaveewat. Touro University Nevada. B391 939.14 MsbA as a Drug Discovery Target for Compounds with Antibacterial Activities. C.A. LaVigne, J.W. McCormick, P.D. Vogel, J.G. Wise. Southern Methodist University. B392 939.15 Inhibition and Dispersion of Biofilms: Targeting Bacterial Response Regulators to Resensitize Multidrug Resistant Bacteria to Antibiotics. M.E. Milton, G.L. Draughn, E.A. Feldmann, R.J. Thompson, D. Jung, B. Kang, K.E. Theisen, D. Zeng, J.L. Lucas, C.C. Melander, J. Cavanagh. RTI International, North Carolina State University, Agile Sciences, Inc. and MRIGlobal. B393 939.16 Kinetic Evaluation of the Reaction of Glutamate Racemase with Computationally Derived Inhibitors Provides Validation of a Successful Pharmacophore Model for a New Line of Antibiotic Therapy. M. Young, E. Wells, O. Dinsmore, J. Marchiano, T. Mahfouz, A. Stockert. Ohio Northern University. B394 939.17 Evaluating the Activity of Bacterial Enzyme DXP Synthase a Potential Target for Newer Antibiotics. A.M. Kessler, S. Anand, K.P. Callahan. St. John Fisher College. B395 939.18 Structural, Biochemical, and Cellular Studies of TarA, the Novel Wall Teichoic Acid Glycosyltransferase, for the Discovery of Gram-Positive Bacterial Inhibitors. M. Kattke, J. Gosschalk, R. Clubb. UCLA. B396 939.19 Analysis of Lysin a from Two Novel Mycobacteriophages. N. Surendranathan. Montclair State University. B397 939.20 Association of Acid Phosphatase-1 (ACP1) Gene Polymorphism with MAI Infection. R.G. Andavolu, A.A S. Rubakovic, O.G. Rodriguez, C. Stafford. Genetic Research Institute of the Desert.
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940. MICROBIOMES Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B398 940.1 Antimicrobial Activity of a High-Pressure Enzymatic Extracts Using Prunus mume. J. Jang, T. Oh. Hanseo University, Republic of Korea, Sunmoon University, Republic of Korea. B399 940.2 The Use of Next Generation DNA Sequence to Determine Fungal Diversity on Potato Tubers Treated with 1,4-Dimethylnaphthalene. R.N. Patel, R.A. Diaz, M.A. Campbell. Penn State Behrend. B400 940.3 The Role of the Negative Control in Microbiome Analyses. K. Edmonds, L. Williams. Providence College. B401 940.4 Bladder and Vaginal Microbiomes Have a Corresponding Shift Following Estrogen Treatment in Post-Menopausal Women. K. Thomas-White, S. Taege, D. Johansen, E.E. Hilt, C. Brincat, E.R. Mueller, L. Brubaker, A.J. Wolfe. Loyola University Chicago. B402 940.5 Gulliver Prototype Development and Deployment. C. Williams, B. Berdy, S. Epstein. Northeastern University. B403 940.6 Microbial Masterpieces: Bacterial Community Profiling in the Hastings College Art Buildings. S. Athy, E. Tidwell, A. Laederach, A. Solem. Hastings College and UNC Chapel Hill. B404 940.7 The Metatranscriptome of the Rhesus Macaque: Investigating Potential Causes of Idiopathic Chronic Diarrhea. S.T. Westreich, A. Ardeshir, M.E. Kable, I. Korf, D.G. Lemay. University of California, Davis and USDA ARS Western Human Nutrition Research Center. B405 940.8 Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study. J.N. Hackman, W. Sangster, J.P. Hegarty, K.M. Schieffer, J.R. Wright, D.R. Toole, R. Drucker, D.B. Stewart Sr., R. Lamendella. Juniata College, The Pennsylvania State University, Wright Labs and LLC. B406 940.9 Effects of a Junk-Food Diet on the Rat Gut Microbiome. A. Gutilla, C. Campbell, M. Pikaart, P. Vollbrecht. Hope College. B407 940.10 Design and Analysis of a Microbiome Mock Community: Understanding and Mitigating Methodological Biases. S. Mosby, M. Kiflezghi, D. Edwards, P.J. Brooks, M. Rivera. Virginia Commonwealth University. B408 940.11 Probiotics Alter Avian Serum Profile to Stimulate Energy Consumption and Change of Gene Expression in Immune Cells. A. Ballou, R. Ali, M. Koci. NC State University.
TUESDAY BIOCHEMISTRY
941.
METABOLISM AND AGING
942. METABOLISM AND CANCER
Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B409 941.1 Resveratrol Shortens the Chronological Life Span of Saccharomyces cerevisiae Under Dietary Glucose Restriction. L. Madrigal-Perez, I. Olivares-Marin, M. CanizalGarcia, J. Gonzalez-Hernandez, G. Nava, M. Ramos-Gomez. Universidad Autonoma de Queretaro, Mexico, Instituto Tecnológico Superior de Ciudad Hidalgo, Mexico and Instituto Tecnologico de Morelia, Mexico. B410 941.2 Association Between the Serum Metabolome and All-Cause Mortality: A Prospective Analysis in the AlphaTocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Cohort. J. Huang, S. Weinstein, S. Moore, J. Sampson, D. Albanes. NIH/NCI. B411 941.3 Teniposide Reduces Vascular Calcification by Inhibiting BMP2 Expression. L. Liu, X. Zhang, Y. Chen, Y. Duan, J. Han. Nankai University, People’s Republic of China. B412 941.4 Time Course Metabolic Profiling of Senescing Flight Muscles in the Hawk Moth, Manduca sexta. B. Wone, J.M. Kinchen, E.R. Kaup, B.W. Wone. University of South Dakota and Metabolon. B413 941.5 Hepatic Metabolic Reprogramming by Caloric Restriction in Rhesus Monkeys. T.W. Rhoads, M.S. Burhans, S.J. McIlwain, P.D. Hutchins, V.B. Chen, H.R. Eghbalnia, I.M. Ong, J.L. Markley, J.J. Coon, R.M. Anderson. University of Wisconsin-Madison and Fred Hutchinson Cancer Research Center. B414 941.6 Sirtuin 3- and Diet-Mediated Regulation of Mitochondrial Function During Aging. R.S. Dhillon, P.R. van Ginkel, V. Fu, T.A. Prolla, J.M. Denu. University of Wisconsin. B415 941.7 The Transmembrane Sequences of Amyloid Precursor Protein Family Members Regulate Their Ectodomain Shedding. G. Multhaup, L. Schauenburg, M. Mayer, C. Walter, M. Eravci, C. Weise, F. Liebsch. McGill, Canada and FU Berlin, Germany.
Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B416 942.1 3D Vasculature Structure in Breast Cancer on a Chip Approaches Through Micromilling. L. Wan, P.R. LeDuc, C. Neumann. Carnegie Mellon University and University of Pittsburgh. B417 942.2 E-Cadherin Regulates Mitochondrial Metabolism and Induces Cell Growth Through NF-κB in E-Cadherin Deficient AGS Cells. S. Park, J. Shin, S. Kee. Korea University, Republic of Korea. B418 942.3 Human Hepatocellular Carcinoma Cells Adapt to ASCT2 and LAT1 Amino Acid Transporter Silencing by shRNA and CRISPR-Cas9. P. Bothwell, B. Bode. Northern Illinois University. B419 942.4 MED28 Mediates Glucose Metabolism in Human Colorectal Cancer Cells. N. Hsieh, C. Huang, Y. Weng, Y. Lin, M. Lee. China Medical University, Taiwan and Chang Jung Christian University, Taiwan. B420 942.5 Involvement of SNX27-Retromer in ASCT2 Trafficking and Glutamine Uptake. Z. Yang, J. Follett, M. Kerr, T. Clairfeuille, B. Collins, R. Teasdale. Institute for Molecular Bioscience, Australia. B421 942.6 Metformin Kills Breast Cancer Cells by Inducing NADH Accumulation, Pyruvate Depletion and Reductive Stress. C.L. Iglesias, B.A. Ratti, C. Kang, A.L. de Abreu, M.G. Bonini. University of Illinois at Chicago. B422 942.7 Succinate Drives Aggressiveness in Breast Cancer. C. Kang, M. Bonini. University of Illinois at Chicago. B423 942.8 An Integrated Biology Approach to Determine Metabolic Dysfunction in Retinoblastoma. N. Guha, L. Winer, V. Suresh Babu, D. Sa, S. Lateef, S. Gundimeda, A. Padmanabhan, B. Dranka, A. Ghosh. Agilent Technologies, India, Agilent Technologies and Narayana Nethralaya, India. B424 942.9 Potential Role for a Phosphoserine Aminotransferase 1 and Pyruvate Kinase M2 (PSAT1:PKM2) Functional Interaction in Lung Cancer Cells. B.F. Clem, T. Kruer, J. Bradley, M. Merchant, J.O. Trent, R.B. Sit. University of Louisville. B425 942.10 Inhibition of Glycogen Metabolism as a Potential Strategy for Anticancer Therapy. V.V. Dukhande, S. Barot, S. Husein, C. Palaguachi. St. John’s University. B426 942.11 Development and Standardization of Methodology for Diagnosis and Detection of Response to Chemotherapy in Patients with Colorectal Cancer. J.V. Assis, L.A. Coutinho, M. de Oliveira Silva Pinto, R.R. Cruz, R.F G. Queiroz. Rene Rachou Research Center, Oswaldo Cruz Foundation, CPqRR-FIOCRUZ, Fiocruz, Brazil.
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BIOCHEMISTRY TUESDAY B427 942.12 Pyruvate Carboxylase Is Essential for Breast Cancer Metastasis in Vivo. T.M. Wilmanski, A. Shinde, S.S. Donkin, J. Burgess, M. Wendt, D. Teegarden. Purdue University. B428 942.13 Combination Therapy to Enhance the Efficacy of Recombinant Immunotoxins: Evaluating the Role of Mitochondrial Translation in Toxin-Mediated Cell Death. Y. Zhu, J. Weldon. Towson University. B429 942.14 Targeting Mitochondrial Molecular Chaperones as a Potential Therapeutic Target in Leukemia. K.G. Bryant, D.C. Altieri. Wistar Institute. B430 942.15 The UDP-Glucuronosyltransferase (UGT) 2A1308arg Variant Isoform: Its Role in Modulating Wild-Type UGT2A1 Activity and Its Association with Lung Cancer Risk. A.K. Sutliff, R. Bushey, J.H. Ashmore, P. Lazarus. Washington State University and Duke University. B431 942.16 Buffer Therapy for Cancer. C.J. Pilot, R. Gillies. The University of Tampa and Moffitt Cancer Center. B432 942.17 Cancer-Specific Cell Death in Response to Palmitoylcarnitine Is Associated with Increased Mitochondrial Hydrogen Peroxide. P.C. Turnbull, C.G. Perry. York University, Canada.
943. METABOLISM AND NUTRITION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B433 943.1 Thimet Oligopeptidase (EP24.15), a Neuropeptide Processing Enzyme Regulatingxenin Signaling. M. Glucksman, K. Philibert, T. Mizuno, P. Lew. Chicago Medical School and University of Manitoba, Canada. B434 943.2 Vitamin E Deficiency Causes Mortality in Zebrafish Embryos via Metabolic Dysregulation due to RedoxMediated Mechanisms. M.Q. McDougall, J. Choi, H. Kim, G. Bobe, E. Ho, J.F. Stevens, E. Cadenas, R. Tanguay, M.G. Traber. Linus Pauling Institute, Oregon State University, Catholic University of Korea, Republic of Korea, University of Southern California and Sinnhuber Aquatic Research Laboratory. B435 943.3 Effects of Acute Aerobic Exercise on Whole Genome Nucleosome Maps and Gene Expression in Skeletal Muscle of Lean vs Overweight/Obese Men. P.M. Devarshi, A.D. Jones, W.W. Campbell, E.M. Taylor, T.M. Henagan. Purdue University. B436 943.4 Isolation, Identification, and Characterization of Local Wild Yeasts for Use in Fermentation. L.N. DeLong, B. Noone, L. Erickson. Salisbury University.
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944. DIABETES, OBESITY AND METABOLIC SYNDROME (II) Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Diabetes, Obesity and Metabolic Syndrome (I), Monday B437 944.1 Role of iNKT Cells in Obese Adipose Tissue. J. Park, J. Huh, Y. Ji, J. Kim. School of Biological Sciences, Institute of Molecular Biology & Genetics, Seoul National University, Republic of Korea. B438 944.2 Anti-Hyperglycemic Effect of ArginylFructosyl-Galactose (AFL) in SD Rat Model Induced Lactase Expression Using Milk Administration. J. Lee, H. Choi, Y. Kim, E. Apostolidis, Y. Kim, Y. Kwon. Hannam University, Republic of Korea, University of Massachusetts, Framingham State University, Chungnam National University, Republic of Korea. B439 944.3 Effects of 3D Culture and Aqueous Cinnamon Extract on 3T3-L1 Adipogenesis. E. Wells, O. Dinsmore, A. Aulthouse, D. Kinder, J. Marchiano, A. Stockert. Ohio Northern University. B440 944.4 Development of Novel Allele Specific PCR Based Assays to Investigate the Contribution of Cortisol to Metabolic Syndrome. B.R. Godlewski, J.R. Salm, B.D. Cohen. Union College. B441 944.5 FoxO1 Localization Changes in Cinnamonium cassia Treated 3T3-L1 Pre-Adipocytes. K. Bova, A. Aulthouse, A. Stockert. Ohio Northern University. B442 944.6 Analysis of Gene Expression in a Female Rat Model of Diet-Induced Non-Alcoholic Fatty Liver Disease Using RNA Sequencing. J.J. Bowman, J.K. Lee, R.A. Perets, M.L. Knabe, J.W. Guider, S. Phillips, U.D. Sarwadnya, S.N. Blythe, N. Toporikova, G.B. Whitworth. Washington and Lee University. B443 944.7 Determining the Association and Interaction of Obesity Gene Risk Variants with Metabolic Disease Phenotypes. J.J. Castillo, V.R. Shah, L. Luo, W.S. Garver. University of New Mexico. B444 944.8 Micro RNAs Mediating Effects of Adipose Angiotensinogen in Adipocyte Inflammation and ER Stress. K.R. Menikdiwela, N. Moustaid-Moussa, L. Ramalingam, S. Scoggin, N.S. Kalupahana. Texas Tech University and University of Peradeniya, Sri Lanka. B445 944.9 Chronic Diabetic Wounds: Longitudinal Profiling of the Evolving Microbiome and Metabolic Landscape in Diabetic Patients. M.B. Ammons, A.L. Fuchs, B.P. Tripet, V. Copie, A.J. Weaver, A. Braaksma, E. Johnson, C. Yeoman. Montana State University and Bozeman Deaconess Health Hospital.
TUESDAY BIOCHEMISTRY B446 944.10 Effect of the Bioactive Compounds Genistein and Resveratrol on Insulin Resistance in Patients with Metabolic Syndrome. E.T. Godínez Salas, M. Guevara-Cruz, P. Villanueva- Luna, M. Guizar-Heredia, G.M. Torres Villalobos, E. Pichardo Ontiveros, G. Ordaz Nava, I. Torres Villalvazo, N. Torres, A.R. Tovar. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico. B447 944.11 Therapeutic Targeting of Skeletal Muscle Nix in Early-Onset Insulin Resistance. S.C. da Silva Rosa, L. Nguyen, Y. Hai, D. Chapman, C. Rampitsch, J.W. Gordon. University of Manitoba, Canada and Children’s Hospital Research Institute of Manitoba, Canada. B448 944.12 Novel Crosstalk Between Insulin and TGFBeta Signaling in Vascular Endothelial Cells. N. Shah, C. Pan, S. Kumar, N. Zaman, F. Elmasry, N.Y. Lee. The Ohio State University Columbus and Ohio. B449 944.13 Environmental Lead (Pb)-Exposure, When Combined with Diet-Induced Obesity, Induces Metabolic and Behavioral Abnormalities in Mice. E.A. Lisznyai, D. Yamin, M. Lisieski, P. Stemmer, T. Leff, S. Perrine. Wayne State University. B450 944.14 Effect of Surfactin Administration on Glucose and Lipid Metabolism in Mice Fed a High Fat Diet. M.A N. Porto, P.R. Marinho, M.E. Oliveira, P.A. Granjeiro, M.E S M. Santos. Federal University of São João del Rei, Brazil. B451 944.15 Improvement of Diabetic Cardiomyopathy by Eryngium carlinae. D. García-Cerrillo, R. Noriega-Cisneros, D. Peña-Montes, R. Salgado-Garciglia, S. Manzo-Avalos, M. Clemente-Guerrero, R. Montoya-Pérez, A. Saavedra-Molina. Universidad Michoacana de San Nicolás de Hidalgo, Mexico. B452 944.16 Attenuation of Mitochondrial Dysfunction During Hepatic Steatosis by Avocado Oil Supplementation. C.i. Garcia-Berumen, O. Ortiz-Avila, C. Márquez-Ramírez, E. Calderón-Cortés, R. Montoya-Pérez, A. RodriguezOrozco, A. Saavedra Molina, C. Cortés-Rojo. Universidad Michoacana de San Nicolas de Hidalgo, Mexico. B453 944.17 Comparative Effects of Avocado Oil and a Thiol Reductant on Impaired Complex I Activity in Mitochondria from Diabetic Rats. M. Hernandez, C. Flores-Ledesma, L. Sánchez-Briones, C. Alonso-Velázquez, R. Aguilar-Toral, J. Campos-García, A. Saavedra-Molina, C. Cortés-Rojo. Universidad Michoacana de San Nicolas de Hidalgo, Mexico. B454 944.18 Expression of Myoinositol Transporters in Nervous System Tissues in the Course of Experimental Diabetes. C.F. Santos, V.X. Farias, P.N. Uchôa, C.P. Aquino, M.C. Fonteles, N.R ‘F. Nascimento. Ceara State University, Brazil and Ceara State University and Mackenzie University, Brazil. B455 944.19 Relation of Hypoglycemic Activity and the Antioxidant Capacity of Justicia spicigera Leaf Extracts in Diabetic Rats. J.A. Martínez-Mora, M. Murillo-Villicaña, R. Salgado-Garciglia, S. Manzo-Avalos, C. Cortés-Rojo, R. Montoya-Pérez, A. Saavedra-Molina. Universidad Michoacana de San Nicolás de Hidalgo, Mexico.
945. LIPIDOMICS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B456 945.1 The Ebola Virus Matrix Protein VP40 Interacts Selectively with Plasma Membrane Lipids to Promote Viral Egress. K. Del Vecchio, A. Shwarz, E. Ollmann Saphire, R. Stahelin. University of Notre Dame, The Scripps Research Institute and Indiana University School of Medicine. B457 945.2 Optimization of ESI Parameters for Comprehensive Lipid Analysis. R.M. Gathungu, P. Larrea, M.J. Sniatynski, B.S. Kristal. Brigham and Women’s Hospital & Harvard Medical School. B458 945.3 Time Resolved IRMS Study of Staurosporine Induced Apoptosis in Murine Astrocyte Cells. K.N. Weber, S.C. Husher, P.A. Mazzer. Dakota Wesleyan University.
946. LIPID SIGNALING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B459 946.1 Homeostatic Regulation of Serine Palmitoyltransferase (SPT) Is Mediated by a Direct Interaction of Ceramide with the SPT/ORMDL Complex. D. Davis, B. Wattenberg. Virginia Commonwealth University. B460 946.2 Differential Growth State-Dependent Activation of p38MAPK by Treatment of Endothelial Cells with Docosahexaenoic Acid (DHA). Y. Du, C.G. Taylor, H.M. Aukema, P. Zahradka. University of Manitoba, Canada and St Boniface Albrechtsen Research Centre, Canada. B461 946.3 Tocopherols and Tocotrienols Prevent Lipoxygenase-Driven Phospholipid Oxidation in Ferroptosis. G. Mao, F. Qu, J. Angeli, C. St Croix, H. Dar, V. Tyurin, V. Ritov, A. Kapralov, A. Amoscato, T. Anthonymuthu, D. Mohammadyani, Q. Yang, B. Stockwell, Y. Tyurina, M. Conrad, H. Bayır, V. Kagan. University of Pittsburgh, Helmholtz Zentrum München, Institute of Developmental Genetics, Germany and Columbia University. B462 946.4 Generating a Transgenic Mouse Line Containing the Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Depletion System. G. Gulyás, B. Szalai, M. Geiszt, T. Balla, L. Hunyady, P. Várnai. Semmelweis University, Department of Physiology, Hungary, NICHD and NIH. B463 946.5 Withdrawn. B464 946.6 Differential Effects of Lipids on Cellular Activities of SH2 Domain-Containing Proteins. I. Singaram, W. Cho. University of Illinois at Chicago. B465 946.7 Orthogonal Lipid Sensors Determine Differential Signaling Roles of PtdIns(3,4,5)P3 and PtdIns(3,4) P2. Z. Wang, S. Liu, W. Cho. University of Illinois at Chicago.
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BIOCHEMISTRY TUESDAY B466 946.8 PIP4Kγ as a Potential Target for Huntington’s Disease. S. Panapakkam Giridharan, I. Al-Ramahi, J. Hasegawa, N. Safren, S. Patnaik, A. Gee, S. Titus, W. Zheng, M. Ferrer, N. Southall, S. Barmada, J. Botas, J. Marugan, L.S. Weisman. University of Michigan, Baylor College of Medicine, National Center for Advancing Translational Sciences and NIH. B467 946.9 Targetting Cysteinyl Leukotriene 2 Receptor as a Therapeutic Target for Tumor Growth and Metastasis: A New Function for an Old Receptor. L.R. Teegala, E. Duah, V. Kondeti, N.Z. Al-Azzam, R. Adapala, S. Ghebreigziabher, C. Thodeti, S. Paruchuri. University of Akron, the University of Akron and Northeast Ohio Medical School. B468 946.10 Single-Molecule Analysis of PKB/AKT-Lipid Interactions. N. Singh, E. Arauz, V. Aggarwal, T. Ha, J. Chen. University of Illinois at Urbana Champaign. B469 946.11 Readers, Writers and Erasers of Nuclear PIP3. R.D. Blind. Vanderbilt University School of Medicine.
947. LIPIDS AND INFLAMMATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B470 947.1 Skin-Specific Stearoyl-CoA Desaturase 1 Deficiency Protects Against Adiposity by Enhancing IL-6 Expression. S.N. Dumas, C. Guo, J.M. Ntambi. University of Wisconsin-Madison. B471 947.2 High Salt Intake Induces Adipogenesis by the Modulation of MAPK/ERK1/2 Pathway in Both 3T3-L1 Adipocytes and Co-Culture with Macrophages. H. Park, J. Kim, S. Bak, M. Lee. Sungshin Women’s University, Republic of Korea. B472 947.3 Effects of High-Fat Diet and Age on the Blood Lipidome and Circulating Endocannabinoids of Female C57BL/6 Mice. S. Pati, S. Krishna, J.H. Lee, C. de La Serre, D. Harn, J. Wagner, N. Filipov, B. Cummings. University of Georgia. B473 947.4 Alcohol and HIV Protease Inhibitor-Induced Inflammasome Activation and Hepatic Lipotoxicity. M. Hinton, W. Pandak, P. Hylemon, H. Zhou. Virginia Commonwealth University and McGuire Veterans Affairs Medical Center. B474 947.5 Lipidomic Analysis of Liver Injury Caused by a ω6-PUFA-Enriched Diet and Ethanol Exposure. D. Warner, M. Miller, X. Yin, X. Wei, A. Prodhan, X. Zhang, A. Feldstein, C. McClain, I. Kirpich. University of Louisville, University of California, San Diego and Robley Rex VAMC. B475 947.6 Inflammatory Generation and Signaling Actions of Conjugated Nitro-Linoleic Acid. F.J. Schopfer, D. Vitturi, L. Minarrieta, S.R. Salvatore, N. Khoo, S. Jobaggy, L. Li, S. Woodcock, R. Berman, A. Ferreira, B. Freeman, L. Villacorta. University of Pittsburgh, Institute for Infection Immunology, Twincore, Germany, University of Michigan and University of La Republica, Uruguay. B476 947.7 Macrophage Cholesterol Efflux and Atherosclerosis in Psoriasis: A Role for microRNA-33. D. Karunakaran, G. Dwevidi, K. Rayner. University of Ottawa Heart Institute, Canada.
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948. LIPID STORAGE AND TRAFFICKING Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B477 948.1 NPC1-Mediated Cholesterol Export from Lysosomes. S.R. Pfeffer. Stanford University. B478 948.2 Sterol O-Acyltransferase 1 Enhances Cholesterol Esterification via Cyclic AMP-Dependent Pathway in the Yolk Sac Membrane Endodermal Epithelial Cells. H. Lin, S. Wang, Y. Chen, H.J. Mersmann, S. Ding. National Taiwan University, Taiwan. B479 948.3 HDLs and LDLs in the Brain: Characterizing the Lipid Secretome of Astrocytes. A. Nguyen. Trinity University. B480 948.4 Sac1 Degrades Its Lipid Substrate PI4P in the ER to Maintain a Steep Electrochemical Gradient on Donor Membranes. G. Hammond, R. Wills, J. Zewe. University of Pittsburgh. B481 948.5 Cholesterol Hydroperoxide Trafficking: Impairment of Macrophage Cholesterol Efflux with Implications for Atherogenesis Under Oxidative Stress. W. Korytowski, K. Wawak, P. Pabisz, A.C. Chadwick, D. Sahoo, A.W. Girotti. Jagiellonian University, Poland and Medical College of Wisconsin.
949. MEMBRANE STRUCTURE, FUNCTION AND ASSEMBLY Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B482 949.1 Functional Reconstitution of the Beta Cell Porosome. A.R. Naik, K.T. Lewis, B.P. Jena. Wayne State University. B483 949.2 Biological Inspiration of Salt Exclusion Membranes in Mangroves Toward Fouling-Resistant Reverse Osmosis Membranes. A.R. Wood, K. Justus, E. Parigoris, A. Russell, P. LeDuc. Carnegie Mellon University. B484 949.3 A Membrane Trafficking Screen to Identify Components Involved in Clathrin-Independent Endocytosis. D. Dutta, J. Wayt, J.G. Donaldson. National Institutes of Health. B485 949.4 Palmitoylation Impact on the Sodium Hydrogen Exchanger Isoform 1 Function. E. Pritsch, A. Holland, A.J. Kooiker, D.E. Rastedt, R.A. Vaughan, J.D. Foster, M.A. Wallert, J.J. Provost. University of San Diego, Bemidji State University, University of Michigan Medical Center, University of North Dakota and School of Medicine and Health Sciences. B486 949.5 Mutation of Follicle Stimulating Hormone Receptor Putative Caveolin Binding Motif Results in Altered Signaling. J.H. Fleischer, B.D. Cohen. Union College.
TUESDAY BIOCHEMISTRY B487 949.6 Functional Characterization of a Novel Caveolin-1 Adenine 474 Deletion (c.474delA Mutation) in TGFβ Signaling and Caveolae Formation. Y. Yuan, G. Marsboom, Z. Chen, R.D. Minshall, J. Rehman, A.B. Malik. University of Illinois at Chicago. B488 949.7 Lipid Raft Disruption Alters Human Follicle Stimulating Hormone Receptor Signaling in a Human Granulosa Cell Line. J.G. Pradhuman, G.R. Geisel, B.D. Cohen. Union College.
B497 950.9 System Xc-. Regulation: Effects of Mutations on Membrane Expression and Ubiquitination Status. M. Schmidt, A. Gibson, E. Hardy, P. Versluis, S. Lang, A. Georges, L. Chase. Hope College. B498 950.10 Inhibition of Na,K ATPase Partial Reactions by Organic Amines. K. Stanley, P. Artigas, C. Gatto. Illinois State University and Texas Tech University Health Sciences Center. B499 950.11 Glucose Transporter (HXT) Homeostasis in Saccharomyces cerevisiae. E. Swain. Presbyterian College.
950. MEMBRANE TRANSPORT AND CHANNELS
951. GLYCOSYLTRANSFERASES AND HYDROLASES
Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B489 950.1 Machinery Mediating Kiss-and-Run Mechanism of Cell Secretion. B.P. Jena. Wayne State University. B490 950.2 Type 2 Diabetes-Associated Variants Disrupt Function of SLC16A11, a Proton-Coupled Monocarboxylate Transporter, Through Two Distinct Mechanisms. E. Hoch, V. Rusu, S.L. Schreiber, J.C. Florez, S.B. Jacobs, E.S. Lander. Broad Institute of MIT and Harvard and Massachusetts General Hospital. B491 950.3 YHM2 From S. cerevisiae and Y. lipolytica: Comparison of Their Role in Oxidative Stress. J. Hartnett, P.N. Pierson, J. Nicaud, P.J. Trotter. Augustana College, INRA and AgroParisTech, France. B492 950.4 Structural and Functional Characterization of Outer Membrane Usher Activation in Uropathogenic E. coli. N. Omattage, Z. Deng, P. Yuan, S.J. Hultgren. Washington University School of Medicine. B493 950.5 In Vitro Activity of a Purified Natural Anion Channelrhodopsin. H. Li, O. Sineshchekov, G. Wu, J. Spudich. University of Texas Medical School at Houston. B494 950.6 Probing the Structural Basis of P-Glycoprotein Transport of μ-Opioid Receptor Agonists: Methadone and Loperamide. M.E. Gibbs, K. Ledwitch, A. Roberts. University of Georgia. B495 950.7 Investigation of a Mitochondrial Twin Arginine Transport Pathway in Arabidopsis thaliana. T.S. Weerakoon, Q. Ma, C. Dabney-Smith. Miami University. B496 950.8 Activation of Akt Increases Cell Surface Expression of System XC- P. Versluis, A. Gibson, M. Schmidt, D. Smith, L. Chase. Hope College.
Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B500 951.1 Dolicholphosphate Mannosyltransferase: A Glycosyltransferase with Unity in Molecular Diversities. K. Baksi, Z. Zhang, D.K. Banerjee. Universidad Central del Caribe, University of Puerto and University of Puerto Rico. B501 951.2 Regiospecificity of Galactan Polymerization by Divergent GlfT2 Orthologs. P.W. Sadecki, A.M. Justen, J.S. Ho, L.L. Kiessling. University of Wisconsin-Madison. B502 951.3 Optimization for Transfection and Isolation of C-Mannosyltransferase DPY19-L1. B. Murdock. Marshall University. B503 951.4 Three-Dimensional Structure of Xyloglucan Xylosyltransferase I and Proposed Mechanism of Catalysis. A.T. Culbertson, A. Tietze, A. Smith, O. Zabotina. Iowa State University. B504 951.5 Investigating the Role of GlfT2 in Mycobacterial Cell Wall Assembly. L.M. Kim, A.M. Justen, L.L. Kiessling. University of Wisconsin-Madison. B505 951.6 Cellulase-Polymer Bioconjugates to Improve Enzyme Stability for Biofuel Production. J. Stewart, T. Wright, B. Schmitz, C. Williams, K. Makaroff, D. Konkolewicz, R.C. Page. Miami University.
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952. PROTEIN-GLYCAN INTERACTIONS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B506 952.1 Real Time Imaging of Tri-Molecular Protein Interactions in Live Cells by Fo¨rster Resonance Energy Transfer (FRET) Microscopy. H. Kuo, N. Chang. National Cheng Kung University College of Medicine, Taiwan. B507 952.2 Electrostatic Contributions of Aromatic Residues in Protein-Carbohydrate Interactions. S.A. Early, R.C. Diehl, L.L. Kiessling. University of Wisconsin-Madison. B508 952.3 Structural Effects of Skp1 Glycosylation. D.F. Thieker, G. Chalmers, X. Xu, M.O. Sheikh, J.N. Glushka, J.H. Prestegard, R. Woods, C.M. West. University of Georgia. B509 952.4 N-Glycan Composition Impacts CD16A Structure and Antibody Binding on Natural Killer Cells. A.W. Barb, K.R. Patel, J.T. Roberts, G.P. Subedi. Iowa State University. B510 952.5 Sulfation Pattern of Chondroitin Sulfates Regulates SHP2, the Non-Receptor Tyrosine Phosphatase. J.K. Tobacman, S. Bhattacharyya, L. Feferman. University of Illinois at Chicago and Jesse Brown VA Medical Center.
953. GLYCANS IN DEVELOPMENT AND DISEASE Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B511 953.1 FUT8 Promotes Breast Cancer Cell Invasiveness Through Remodeling of TGF-β Receptor Core Fucosylation. C. Tu, M. Wu, Y. Lin, R. Yang. Institute of Biomedical Sciences and Academia Sinica, Taiwan. B512 953.2 Glycolipid Storage and Phenotypes in a New Rat Model of Fabry Disease. J.J. Miller, K. Aoki, C.A. Murphy, C.L. Stucky, I.S. Kassem, M. Tiemeyer, N.M. Dahms. Medical College of Wisconsin and University of Georgia.
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B513 953.3 Identification of a Post-Translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy: Roles of ISPD, Fukutin, and FKRP in α-Dystroglycan Glycosylation. M. Kanagawa, K. Kobayashi, M. Tajiri, H. Manya, A. Kuga, Y. Yamaguchi, Y. Wada, T. Endo, T. Toda. Kobe University, Japan, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan and RIKEN Global Research Cluster, Japan. B514 953.4 A Novel Hemolysin with Anti-Cancer and Anti-Fungal Properties Binds to Serum Glycoproteins and Cholesterol. C. Welch, N. Fan, R. Brown, M. Talaga, A. Fueri, K. Driscoll, K. Lawry, A. Vizurraga, R. Rekhi, P. Bandyopadhyay, T. Dam. Michigan Technological University.
954. GLYCAN BIOTECHNOLOGY AND DRUG DEVELOPMENT Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B515 954.1 Deconvolution of Glycan Occupancy Heterogeneity for Rational HIV Immunogen Design. W. Yu, P. Zhao, M. Draghi, C. Arevalo, C. Karsten, L. Wells, D. Lauffenburger, G. Alter. Massachusetts Institute of Technology, Ragon Institute and Complex Carbohydrate Research Center. B516 954.2 Mannose Moieties Exhibit Self-Adhesive Interactions. K.H. Perera, P.L. Chandran. Howard University. B517 954.3 GRP78 Is Neither Expressed on Er-/PR-/Herr2Human Breast Cancer Cell Surface nor Secreted. J.E. Serrano, E.C. Romero-Nutz, N. Sanchez, A. Banerjee, K. Baksi, D.K. Banerjee. University of Puerto Rico and Universidad Central del Caribe. B518 954.4 Arabidopsis Plants Expressing a Fungal Pectin Methylesterase Enzyme Have Reduced Degree of Polysaccharide Methylation and Exhibit a Dwarfed Phenotype and Resistance to Stresses. L. Chambers, O. Zabotina, N. Reem, S. Abdullah. Iowa State University. B519 954.5 Bifidobacterium dentium Regulates Intestinal Mucus Production and Glycosylation. M.A. Engevik, B.K. Luk, C. Visuthranukul, J. Versalovic. Baylor College of Medicine, Texas Children’s Hospital and King Chulalongkorn Memorial Hospital, Thailand.
TUESDAY NUTRITION
Nutrition 955. INNOVATION AND VALIDATION OF DIETARY ASSESSMENT TOOLS AND THEIR APPLICATIONS Poster (Sponsored by: Nutritional Epidemiology RIS) Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C1 I 955.1 An Improved Method for Scoring the Moderation Components of a Diet Quality Index. G. Ricart, P.J. Brewster, P.M. Guenther. University of Utah. C2 II 955.2 Household Dietary Diversity Indicators in Rural Central America. R. Sibrian, P. Palma de Fulladolsa. SG-SICA/PROGRESAN, El Salvador. C3 I 955.3 Dietary Long-Chain Fatty Acids and Carbohydrate Biomarkers Evaluation in a Controlled Feeding Study in Participants from the Women’s Health Initiative Cohort. X. Song, Y. Huang, M. Neuhouser, L. Tinker, M. Vitolins, J. Siddique, R. Prentice, J. Lampe. Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Wake Forest School of Medicine and Northwestern University Feinberg School of Medicine. C4 II 955.4 Gender Analysis of Dishes with High Contribution of Energy and Nutrient Intakes Among Korean Adults. M. Kang, J. Lee, J. Shim, H. Paik. Korea Federation of Women’s Science & Technology Associations, Republic of Korea, Seoul National University, Republic of Korea, Daejeon University, Republic of Korea. C5 I 955.5 Validation of the Dietary Screening Tool in a Middle-Aged Appalachian Population. M.V. Marra, S.V. Thuppal, R.L. Bailey, E. Johnson. West Virginia University, Purdue University and Tufts University. C6 II 955.6 Serum Stable Isotope Biomarkers Are Moderately Associated with Added Sugar, Fish and Meat Intake in 153 Postmenopausal Women. H. Yun, J.W. Lampe, M.L. Neuhouser, L.F. Tinker, R.L. Prentice, D.M. O’Brien. University of Alaska Fairbanks and Fred Hutchinson Cancer Research Center. C7 I 955.7 Comparison of an Automated Exit Survey with a Multi-Pass Meal Recall Interview in Assessing Nutrient Intake of Undergraduates at a University Dining Hall. M. Slavin, A. Hauver, K. Brennan, L. Durant, A. Best. George Mason University. C8 II 955.8 Association Between Socioeconomic Status and the Mexican Diet Quality Index Score in Adults. Results from the Mexican National Health and Nutrition Survey 2012. N. Lopez-Olmedo, L. Taillie, B.M. Popkin. University of North Carolina at Chapel Hill. C9 I 955.9 Comparison of Traditional InterviewerAdministered 24-Hour Dietary Recall with Web-Based Automated Self-Administered 24-Hour Dietary Recall in South Asian Students. S. Jasti, E. Elvelin, C. Doak. Queens College and VU University of Amsterdam, Netherlands.
C10 II 955.10 Combining Same-Day Student Food Diaries with ASA-24 Interviews and Coding to Accurately Assess the In-School Food Consumption of 4th to 6th Graders. K. Niland, R. Cohen, R. Briefel, M. Hu, A. Magness, M. Crepinsek. Mathematica Policy Research, USDA and FNS. C11 I 955.11 Facial Imagery BMI Algorithm Correlates with Normal and Overweight Measured BMI. M.L. Barr, O.A. Famodu, G. Guo, S.E. Colby, M.D. Olfert. West Virginia University and University of Tennessee. C12 II 955.12 Determination of a Lower Limit of Para-Aminobenzoic Acid (PABA) Recovery for Identifying Complete 24-h Urine Collections by High-Performance Liquid Chromatography (HPLC). B.R. Taylor, V. Sagi-Kiss, L. Freedman, D. O’Brien, C. Johnston, N. Tasevska. Arizona State University, Sheba Medical Center, Israel, University of Alaska Fairbanks. C13 I 955.13 Palmitic and Stearic Free Fatty Acids Are Consistently Found in Materials Used for Dried Blood Spot Collection. J. Gunash, J.J. Aristizabal Henao, K.D. Stark. University of Waterloo, Canada. C14 II 955.14 Methodology for Classifying Regularity of Eating Patterns Through Within-Subject Variability in Dietary Recall Variables. D. Delane, A. Kazaks, C. Harris, C. Bartok, L.M. Baldiviez, C.B. Stephensen, N.L. Keim. Bastyr University and University of California Davis.
956. NUTRITION TRANSLATION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C15 I 956.1 Characterization of Anthocyanins in Sweetpotato Leaves. X. Su, J. Griffin, X. Chen, J. Xu, W. Wang. Kansas State University. C16 II 956.2 Reduction of Phenolic Content of Green Leaf Lettuce Grown in the High Tunnels. J. Xu, X. Su, S. Sumpter, S. Barry, Y. Shen, X. Chen, C. Rajashekar, W. Wang. Kansas State University. C17 I 956.3 The Effects of Using Banana Flour as a Gluten Substitute in Cookies. B. Goble, K. Lawson, M.E. Johnson, E. Yates, W.A. Clark. East Tennessee State University. C18 II 956.4 Using Bananas as a Replacement for White Sugar in a Curry Ice Cream Recipe. V. Zaleski, J. Miller, K. Hirko, W.A. Clark, M.E. Johnson. East Tennessee State University. C19 I 956.5 Concentrations of 19 Perfluorinated Compounds in Saltwater and Freshwater Fishes Analyzed by Liquid Chromatography-Tandem Mass Spectrometry. Y. Jeong, S. Choi, S. Chun, K. Lee. Korea University, Republic of Korea. C20 II 956.6 Method Validation for the Analysis of Perfluorinated Compounds in Rice. S. Choi, Y. Jeong, S. Chun, S. Lee, J. Kim, Y. Kho, K. Lee. Korea University, Republic of Korea, Eulji University, Republic of Korea.
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NUTRITION TUESDAY C21 I 956.7 Reduction of Polycyclic Aromatic Hydrocarbons in Dried Red Peppers (Capsicum annuum L.) by Applying an Alternative Drying System. M. Hwang, S. Yang, S. Kang, K. Lee. Korea University, Republic of Korea. C22 II 956.8 Vitamin C Content in Dried and Brewed Green Tea from the US Retail Market. M. Somanchi, K. Phillips, E. Haile, P. Pehrsson. USDA and Virginia Polytechnic Institute and State University. C23 I 956.9 Nutrition Education on a Global Scale: Extending Reach and Influence. H. Truby, M. Adamski, J. Dart, E. Volders, M. Blumfield, C. Murgia, A. Devey, S. Gibson. Monash University, Australia. C24 II 956.10 Understanding the Barriers to Whole Grain Consumption Among Low-Income Adults. M. Chea, J.S. Foster, J.D. Chiero, A.R. Mobley. University of Connecticut. C25 I 956.11 Whole Grain Gluten-Free High Protein Buckwheat-Kale Snacks. T.S. Kahlon, R.J. AvenaBustillos, M.M. Chiu. Western Regional Research Center and USDA-ARS. C26 II 956.12 Low-Income Women in Iowa Lack Awareness of the Health Benefits of Beans. D.M. Winham, S.M. Palmer, J.L. Baier, T.A. Roe. Iowa State University. C27 I 956.13 Right Time to Sprinkle Pepper. J. Lee, A. Choi, D. Kim, M. Yon, J. Nam, S. Park, H. Lee, G. Lee, K. Lee, C. Kim. KHIDI, Republic of Korea, Department of Chemistry, Chungnam University, Republic of Korea. C28 II 956.14 Verifying Fibers Meet Regulatory Definitions for Nutrition Facts Labeling: A Randomized, Controlled Trial Evaluating Polydextrose in a Wet Matrix. S. Rahman, E. Park, D. Xiao, I. Edirisinghe, B.M. BurtonFreeman. Illinois Institute of Technology. C29 I 956.15 Content and Quality of Nutrition-Related Information Disseminated in the Newspapers with the Highest Readership in Lima, Peru. J.F. Oxenstein, A. Campa. Florida International University.
957. NUTRITION EDUCATION AND BEHAVIOR CHANGE Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C30 I 957.1 An Exploratory Study Examining the Impact of Participating in a Nutrition-Education and Culinary Skill-Building Program on Adolescents’ Dietary Intake Using the Remote Food Photography Method. M.E. Robin, M. Cater, D. Miketinas, A. Bailey, K. Rhea, C.K. Martin, G. Tuuri. Louisiana State University, Louisiana State University Agricultural Center and Pennington Biomedical Research Center. C31 II 957.2 Evaluation of Internal Consistency and Test-Retest Reliability of a Food Behavior Checklist for LowIncome Filipinos. A. Suzuki, S. Choi, E. Lim, S. Tauyan, J. Banna. University of Hawaii. C32 I 957.3 Validity and Reliability of a Nutrition Knowledge Questionnaire for Adolescents. L.D. Ruiz, A.M. Jones, R.E. Scherr. University of California at Davis.
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C33 II 957.4 Participation in a Summer Culinary SkillBuilding Camp Increased Adolescents’ Knowledge, Motivation and Confidence to Cook, and Consumption of Healthy Foods. K. Rhea, M. Cater, S. Charles, D. York, G. Tuuri. Louisiana State University, Louisiana State University Agricultural Center and Southern University Agricultural Center. C34 I 957.5 Do Adults Drink During Meals or Outside Meals? Results of the Liq.in7 Cross Sectional Surveys. I. Guelinckx, C. Morin. Danone Research, France. C35 II 957.6 Timing of Lifestyle Modification for Type II Diabetes Mellitus : Meta Analysis of Effectiveness. D. Shin, Y. Park. Kyungnam Univeristy, Republic of Korea. C36 I 957.7 Nordic Solutions to Increase Fruit and Vegetable Consumption: Lessons from Four Years of Retail Behavioral Economics Interventions. B. Wansink, K.I. Karevold, H. Tran. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C37 II 957.8 Bigger Homes & Recipes: How Recipe Calories Have Increased Over the Years. B. Wansink, A. Mukund. Cornell University and University of Washington. C38 I 957.9 Do Parents with the Authoritative Feeding Style Have Better Food Parenting Practices? J. Baietto, R.L. Vollmer. Illinois State University and Bradley University. C39 II 957.10 A Mindful Eating Intervention to Improve Self-Management of Dietary Intake for Early Stage Chronic Kidney Disease Patients. M.J. Tahir, G.M. Timmerman, R.M. Lewis, D. Samoson, H. Temple, M.R. Forman. The University of Texas at Austin, North Austin Medical Center and Austin Kidney Associates. C40 I 957.11 Self-Reporting a Healthy Diet and Dietary Practices Among Undergraduate Nutrition and NonNutrition Majors. G.R. Lewis, S. Cortazar Moya, B.T. Pope, J.R. Ricketts, K.A. Alcance, A. McDaniels, N. Hongu. University of Arizona. C41 II 957.12 The Fat “Value”: How Fat-Related Words in Chain Restaurants Menu Bias Expectations. B. Wansink, A. Mukund, C.M. Velez Argumedo. Cornell University, University of Washington and EGADE Business School, Mexico. C42 I 957.13 Nutritional Knowledge of Mothers/ Caregivers in Relation to the Anthropometric Indices of Children (2–5 Years) in Obowu Local Government Area, Imo State, Nigeria. N.M. Oly-Alawuba, S. Ihedioha. Imo State University, Nigeria. C43 II 957.14 Technology at Mealtimes: Exploring the Relationship Between Food Parenting Practices, Parental Technology Distraction and Child Food Neophobia. M. Gramm, T. Harpel, B. McDaniel, J. Schumacher, R.L. Vollmer. Illinois State University and Bradley University. C44 I 957.15 Gender Differences in BMI, Relationship Status, and Weight Control Behaviors over Time. I. van Woerden, M. Bruening. Arizona State University. C45 II 957.16 Evaluation of a Nutrition Education Program Implementation for Portuguese Students from 1st Grade to 10th Grade. N. Tavares, A. Abreu, I. Martins, J. Barreira, M. Crespo, R. Faria. CBIOS—Universidade Lusófona de Humanidades e Tecnologias, Portugal. C46 I 957.17 Educational Messaging at Breakfast, Not Protein Source, Influences Appetite Response, Food Preferences, and Food Intake in Men and Women. J.I. Baum, B.L. Neumann, C.F. Mitchell, G. Kubas, S. Russell. University of Arkansas.
TUESDAY NUTRITION C47 II 957.18 Effective Delivery of Social-Behavioral Change Communication Through a Care Group Model in a Supplementary Feeding Program: A Descriptive Analysis. L. Wilner, D. Suri, B.K. Langlois, S. Walton, B. Rogers. Tufts University. C48 I 957.19 Farmers’ Market Use Is Associated with Fruit and Vegetable Consumption Among Low-Income Populations: A Cross-Sectional Study from Southern Arizona. H. Alaofe, N. Downs, K. Jones, A. Plano. University of Arizona and Community Food Bank. C49 II 957.20 Eating Behaviors of Adolescents in New Versus Established Urban Centers in South India. N. Shaikh, B. Guo, K. Narayan, S. Patil, R. Kuriyan, S. Cunningham. Emory University, National Institutes of Health, BLDE University, India and St. John’s Research Institute, India. C51 II 957.22 Relationships Between Physical Activity, Food Choices, Gender, and BMI in Southern California Teenagers. J.B. Gaylis, S.S. Levy, S. Kviatkovsky, R. Dehamer, M. Hong. San Diego State University. C52 I 957.23 Relationships Between Body Weight Perception, Body Mass Index, and Food Choices in Southern California Adolescents. J.B. Gaylis, S.S. Levy, M. Hong. San Diego State University. C53 II 957.24 Let’s Talk Food: Identifying Perceived Barriers and Enablers of Healthy Eating in College Students in Hawai’i. L.P. Amore, J. Banna. University of Hawai’i at M?noa. C54 I 957.25 “You’re Getting Fat”: Childhood Weight Comments and Adult Daughter Satisfaction. B. Wansink, D. Cristian, L. Warlop. Cornell University, Norwegian Business School, Norway and KU Leuven, Belgium. C55 II 957.26 Use of Multiple Household Food Inventories to Measure Food Availability: Health Happens Preschool Program. M.E. Waddill, M.E. Spence, K. Aaron, R. Parrott, L. Woods. University of Tennessee and East Tennessee Children’s Hospital. C56 I 957.27 Identifying Changes in Body Weight, Composition and Dietary Intake During First-Year University. K.M. Beaudry, A.M. Thomas, B. Falk, W.E. Ward, A.R. Josse. Brock University, Canada. C57 II 957.28 Identifying Changes in Physical Activity, Body Weight, and Body Composition in First Year University Students. A.M. Thomas, P. Klentrou, P. Klentrou, K. Gammage, A. Josse. Brock University, Canada. C58 I 957.29 Baked Beats Grilled: A Calorie Analysis of 18,000 Menu Items in Fast Food Chain Restaurants. B. Wansink, A. Mukund, S. Atakan. Cornell University, University of Washington and Ozyegin University, Turkey. C59 II 957.30 The Effects of Distraction on Consumption, Food Preference, and Satiety: A Proposal of Methods. C.A. Liguori, S.M. Nickols-Richardson. University of Illinois at Urbana-Champaign. C60 I 957.31 Trying to Keep Up: Energy Drink Consumption, Student Involvement, and Sleep Among Diverse College Freshmen. R. Bender, S. Brennhofer, M. Mason, M. Bruening. Arizona State University. C61 II 957.32 Impact of Healthy Choices in Motion on Physical Activity Knowledge. D.S. Fetter, R.E. Scherr, J.D. Linnell, M. Gerdes, M. Dharmar, S. Zidenberg-Cherr. University of California, Davis, Oregon State University Extension Service, Tillamook and Lincoln Counties, University of California Davis Health System and University of California Agriculture and Natural Resources.
C62 I 957.33 Relationships Between College Students’ Cognitive Load Level and Personality, Health, Weight-Related Behaviors, Body Image and Family Life. K. Eck, C. Byrd-Bredbenner. Rutgers University. C63 II 957.34 Setting the Stage for Childhood Fitness: Dietary Energy Density IsAssociated with Locomotor Development in a Nationally Representative Sample of US Children Age 3–5 y. J. DiGiovanni, J.A. Vernarelli. Fairfield University. C64 I 957.35 Surfing the Web While Fishing for Food: A Pilot Study Examining Cell Phone Use During Mealtime. S. Fanelli, B. Wansink. Cornell University. C65 II 957.36 Evaluation of Caloric and Macronutrient Content of Meals Sent from Home and Meals Provided in a CACFP Certified Preschool Program. L. Woods, M. Spence, T. Harris, M. Waddill, R. Parrott, K. Aaron, S. Colby, K. Kavanagh. University of Tennessee and East Tennessee Children’s Hospital. C66 I 957.37 Effects of Nutrition Intervention on Nutritional Status, Physical Activity and Life Quality of Breast Cancer Survivors. F.L. Yang, L. Hsiao-Hsuan, L. Man-Ting. Fu Jen Catholic University and Department of Nutritional Science, Taiwan. C67 II 957.38 Incorporation of Online Nutrition CME Courses in State-Level Education Libraries Aid to Improve Physician Knowledge. K. Hicks, P.S. Murano. Texas A&M University. C68 I 957.39 Vital: Evaluation of a Digital Learning Object to Enhance Student Learning of Vitamins and Minerals. D.J. Good, S. Gallo, J. Akers, T. Drape, D. Hu, L. Baab. Virginia Tech, George Mason University and James Madison University. C69 II 957.40 Applying User-Centered Design to Developing Videos to Educate Parents on Healthful Feeding Practices of Young Children in a Low-Income Community: A Caminitos Collaborative Project. J. Coronado, L. BeidigerFriedman, S.H. Crixell, C. Courtney. Texas State University.
958. EARLY CHILDHOOD NUTRITION Poster Maternal, Perinatal and Pediatric Nutrition RIS Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C70 I 958.1 Effects of Repeated Texture Exposure on Young Children’s Intake and Liking of Yogurts. S. Lee, M. Baniasadidehkordi, H. Joyner, C. Ross, W. Price, S. Ramsay. University of Idaho and Washington State University. C71 II 958.2 Soy-Based Infant Formula Feeding and Impact on Estrogen-Responsive Tissue. V.A. Stallings, M.A. Adgent, D.A. Umbach, B.S. Zemel, A. Kelly, J.I. Schall, E.G. Ford, K. James, K. Darge, J.C. Botelho, H.W. Vesper, D.W. Chandler, J.M. Nakamoto, W.J. Rogan. Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, National Institute of Environmental Health Sciences, Vanderbilt University School of Medicine, Social & Scientific Systems, Inc., Centers for Disease Control and Prevention, Endocrine Sciences, LabCorp and Quest Diagnostics Nichols Institute.
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NUTRITION TUESDAY C72 I 958.3 Formula Overfeeding and Weight Status Among Infants and Toddlers from a WIC Clinic in Puerto Rico. K. Amaro-Rivera, C. Palacios. University of Massachusetts Medical School, University of Puerto Rico and Medical Sciences Campus, Puerto Rico. C73 II 958.4 Body Composition in Infants at Two and Four Months of Age According to the Type of Feeding. Preliminary Data. N. Muñoz-Esparza, E.M. Vasquez-Garibay, A. Larrosa-Haro, E. Guzmán-Mercado, S. Apodaca, N. Badillo, M. Mancilla-Madrid, E. Romero-Velarde. University of Guadalajara, Mexico. C74 I 958.5 Sodium Intake Assessment in a Sample of Australian Pre-School Children Attending Long Day Care. S. O’Halloran, K.E. Lacy, C.A. Grimes, K.J. Campbell, C.A. Nowson. Deakin University, Australia. C75 II 958.6 Associations of Maternal Omega-3 and Omega-6 Polyunsaturated Fatty Acid Intake During Pregnancy and Offspring Adiposity and Metabolic Risk During Peripuberty. M. Alhinai. University of Michigan. C76 I 958.7 Playing with Food: How Touch Facilitates a Child’s Intake of Unfamiliar Foods. H. Kessler, B. Wansink, F. Zampollo, M. Shimizu, S. Atakan. Cornell University, Online School of Food Design, New Zealand, Southern Illinois University and Ozyegin University, Turkey. C77 II 958.8 Examining the Impact of Implementation of the Comprehensive Nutrition Program, Rainbow in My Tummy®, in the Child-Care Setting. M.E. Johnson, L. Veitch, E. Carpenter, W.A. Clark. East Tennessee State University. C78 I 958.9 Developmental Changes in Resting Gamma Power from Age Three Months to Five Years Are Modulated by Infant Diet. R.T. Pivik, A. Andres, M.A. Cleves, K.B. Tennal, Y. Gu, T.M. Badger. Arkansas Children’s Nutrition Center and University of Arkansas for Medical Sciences. C79 II 958.10 Consumption of Healthy or Unhealthy Foods Affects the Risks of Developing Overweight/Obesity and Hypercholesterolemia in Preschool Children. K.C. Jen, S. Xu, Y. Yeh, K.B. Hartlieb. Wayne State University, Texas A&M University and Florida International University. C80 I 958.11 Relationship Between Solid Food Introduction and Picky Eating in the STRONG Kids 2 Cohort. N.C. Cole, S. Lee, S.M. Donovan. University of Illinois at Urbana-Champaign. C81 II 958.12 Withdrawn. C82 II 958.13 Expert Approaches to Increase a Child’s Vegetable Intake: A Qualitative Examination of Techniques and Tactics. H. Kessler, S. Fanelli, M. Katz, B. Wansink. Cornell University and Medical Nutrition Therapy. C83 I 958.14 Dining with Grace: prayerful Preschooler Families Act Better Than They Eat. H. Kessler, C.S. Wansink, B. Wansink. Cornell University and Second Presbyterian Church. C84 II 958.15 Rapid Rescue of Vitamin D Levels Between 1 and 3 mo of Age in Neonates with Low Vitamin D Levels Using a Daily Supplementation Dosage of 1200 IU Supports Higher Bone Mineral Accretion. N.J. Gharibeh, H.A. Weiler, C.A. Vanstone. McGill University, Canada. C85 II 958.16 Anemia During Infancy Affects the Fecal Microbiome and Fecal and Serum Metabolomes. S. McClorry, N. Zavaleta, A. Llanos, M. Casaría, B. Lönnerdal, C. Slupsky. UC Davis and Cayetano Heredia Foundation, Peru.
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C86 II 958.17 Serum Concentration of Lipids in Infants According to the Type of Feeding. Preliminary Data. E. Romero Velarde, E.M. Vasquez Garibay, A. Larrosa Haro, N.C. Muñoz Esparza, E. Guzmán Mercado, P. Ascencio Esparza. Hospital Civil de Guadalajara, Mexico and Universidad de Guadalajara, Mexico. C87 II 958.18 Diet Quality, Water and Toilets Remain a Lingering Challenge for Undernutrition in India. S. Cyriac, P. Menon, V. Aguayo. Emory University, International Food Policy Research Institute, India and UNICEF. C88 I 958.19 Effect of Holder Pasteurization and Retort Processing on Bioactive Components and Nutritional Content of Human Milk. H.K. Lima, M. Wagner-Gillespie, C. Hubble, K. Vogel, M. Perrin, A.D. Fogleman. North Carolina State University, WakeMed Mothers’ Milk Bank and University of North Carolina Greensboro. C89 II 958.20 Human Milk Fortification for Preterm Infants: Deficiencies and Excesses in Micronutrients. W. Koo. Louisiana State University. C90 I 958.21 Responses of Preterm Pigs Fed Bovine Colostrum and Formulas with Either Lactose or Maltodextrin as the Sources of Carbohydrate. R.K. Buddington, K.K. Buddington. University of Memphis. C91 I 958.22 Leucine Improves Growth of Preterm Pigs. R.K. Buddington, K.K. Buddington. University of Memphis. C92 II 958.23 The Impact of Family Style Meal and Modeling on Dietary Behaviors and Intake of Children Participating in a Developmental Playgroup. E.V. Mitchell, P. Ghosh Roy, C. Odeh, D. Fannin, S. Barrett. Northern Illinois University. C93 I 958.24 First Trimester Maternal Adiposity Is Associated with Infant Body Fat at Age 2 Weeks: A Longitudinal Follow-Up Study. A. Andres, M.L. Ruebel, R.A. Krukowski, T.M. Badger, K. Shankar, M.A. Cleves. Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Michigan State University and University of Tennessee Health Science Center. C94 I 958.25 Frequency of Antenatal Care Visit Is a Key Modifiable Determinant of Low Birth Weight in Malawi. A.T. Chikakuda, S. Song, W. Song. Michigan State University.
959. FEEDING BEHAVIOR OF THE MOTHER, INFANT AND OTHER CAREGIVERS Poster Maternal, Perinatal and Pediatric Nutrition RIS Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C95 I 959.1 Sleep and Food Choices: Women’s Experiences from an International Sample. R.E. Walker, M. Blumfield, H. Truby. Monash University, Australia. C96 II 959.2 Maternal Mental Health and Child Feeding Behaviors in Eastern DR Congo: A Qualitative Study. J.A. Emerson, W. Tol, S. Doocy, L.E. Caulfield. Johns Hopkins Bloomberg School of Public Health and Peter C. Alderman Foundation.
TUESDAY NUTRITION C97 I 959.3 Exploring Physicians’ Perspectives on Nutrition Education Delivery to the Mother-Infant Dyad. A.L. MacMillan Uribe, A.I. Martonffy, B.H. Olson. University of Wisconsin-Madison. C98 II 959.4 An International Perspective of Women’s Beliefs and Experinces Regarding Gestational Weight Gain and Antenatal Care. R.E. Walker, M. Blumfield, H. Truby. Monash University, Australia. C99 I 959.5 Infant Feeding Mode Is Associated with Differences in Postpartum Weight Retention and Percent Body Fat from 2 To 16 Weeks. N.L. Motoyasu, P.K. Berger, A.K. Anderson, J.J. Smith, L.L. Birch. The University of Georgia and The University of Southern California. C100 II 959.6 Infant Feeding Practices in the First Six Months of Life and Subsequent Growth Performance. L. Shinn, C. Tangney, M. Mullen, C. Sharp, A. Gelfand, C. Busche. Rush University Medical Center. C101 I 959.7 “Those Who Care Much, Understand Much.” Maternal Perceptions of Children’s Appetite: Perspectives from Urban and Rural Caregivers of Diverse Parenting Experience. S.B. Ickes, N. Naila, B. Nahar, G. Ritter, M. Lazarus, M. Hossain, T. Ahmed, J. Walson, D. Denno. University of Washington, International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Bangladesh. C102 II 959.8 Multi-Site Trial Using Short Mobile Messages (SMS) to Improve Infant Feeding Practices Among Participants in the WIC Program. C. Palacios, M. Campos, C. Gibby, J. Banna. University of Puerto Rico and University of Hawaii at Manoa. C103 I 959.9 Determinants of Infant Growth Within the First Six Months of Life. A. Burklin, K. Wilson, C. Lovelady. The University of North Carolina at Greensboro. C104 II 959.10 Influence of Maternal Stress, Number of Children, and Marital Status on Maternal Restrictive Feeding Practices of Preschool-Age Children. C.L. Smith, K. Swyden, A. Weedn, A.L. Salvatore, R. Terry, S.B. Sisson. University of Oklahoma Health Sciences Center and University of Oklahoma. C105 I 959.11 Breastfeeding Counseling Improves Maternal-Infant Feeding Interaction in Those Exposed to Controlling Behavior or Emotional Violence: MINIMat Study in Bangladesh. A. Frith, S. Ziaei, E. Frongillo, A. Khan, E. Ekstrom, R. Naved. Ithaca College, Uppsala University, Sweden, University of South Carolina, (ICDDR, B), Bangladesh. C106 II 959.12 Understanding Income Disparities in Infant Feeding Practices: Parent Voices and Practitioner Experiences. D. Siegel, M. Fuster. Brooklyn College. C107 II 959.13 Early Breastfeeding Initiation, Prelacteal Feeding, and Infant Feeding Are Associated with Biomarkers of Environmental Enteric Dysfunction. E.R. Smith, K. Manji, C.M. McDonald, K. Gosselin, R. Kisenge, W. Fawzi, A.T. Gewirtz, C. Duggan. Boston Children’s Hospital, Muhimbili University of Health and Allied Sciences, Tanzania, Harvard T.H. Chan School of Public Health and Georgia State University. C108 I 959.14 The Effect of Nighttime Energy Intake on BMI-Z Scores During Early Childhood. L.A. Alnaim, M. Taylor, J. Thodosoff, D. Sullivan, S. Carlson. University of Kansas Medical Center. C109 II 959.15 Family Meal Characteristics Are Associated with Maternal Weight and Obesity Risk. J. MartinBiggers, V. Quick, C. Byrd-Bredbenner. Rutgers University.
C110 I 959.16 Association Between Maternal Dietary Inflammatory Index Score During Pregnancy and Child Wheeze at Age Three Among Children from Shelby Co, TN. A. Kowalski, K. Carroll, N. Shivappa, A. Roy, M. Kocak, S. Steck, J. Hebért, F. Tylavsky, T. Hartman. Emory University, Vanderbilt University Medical Center, University of South Carolina and University of Tennessee Health Science Center. C111 II 959.17 Cross-Nursing in a Peruvian Peri-Urban Area. R.G. Pareja, G.S. Marquis, M.E. Penny. Instituto de Investigación Nutricional, Peru and McGill University, Canada.
960. NUTRITION AND DEVELOPMENT Poster Maternal, Perinatal and Pediatric Nutrition RIS Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C112 I 960.1 A Concept Analysis of Premature Infant Growth Failure. L. Schehr. University of Wisconsin Milwaukee. C113 II 960.2 Bone Mineral Accretion Is Increased During Winter and Is Positively Related to Lean Mass Accretion and Calcium Intake in Healthy Children 2–8 y. N.R. Brett, C.A. Vanstone, H.A. Weiler. McGill University, Canada. (316.1) C114 II 960.3 Development of an Obesity Risk Score for Mothers of Young Children. J. Martin-Biggers, V. Quick, C. Byrd-Bredbenner. Rutgers University. C115 I 960.4 Energy Density in Nulliparous Women Planning Pregnancy: Results from the ISIS Study. W. Fan, M.B. Goldman, J.L. Fung, P. Hsiao, D.C. Mitchell, T.J. Hartman. RSPH, Emory University, Geisel School of Medicine at Dartmouth, Indiana University of Pennsylvania and Penn State University. C116 II 960.5 The Association of Weight and Nutrient Intakes with Preterm Infants in Neonatal Intensive Care Unit in Taiwan. S. Huang, C. Huang, M. Lee. Chung Shan Medical University, Taiwan, Asia University, Taiwan and Changhua Christian Children Hospital, Taiwan. C117 I 960.6 Nutrient Assessment of Chinese Pregnant and Lactating Women: The Intakes and Food Sources of Folic Acid, Vitamin A, Iron and Calcium. W. Zhao, K. Ning, Y. Zheng, A. Zhao, P. Wang, Y. Zhang. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, People’s Republic of China, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, People’s Republic of China, Department of Social Medicine and Health Education, School of Public Health, Peking University, People’s Republic of China. C118 II 960.7 Neonatal Iron Status at Birth Is Independently Regulated by Fetally Derived Hepcidin in Neonates Born to Women Carrying Multiple Fetuses. Y. Ru, E.K. Pressman, R. Guillet, E.M. Copper, P.J. Katzman, K.O. O’Brien. Cornell University and University of Rochester Medical Center. (316.3) C119 I 960.8 Access to Health Insurance and Prenatal Care on Low-Income Pregnant Women’s Nutritional Status. A.S. Horan, H. Kim. Alma College. C120 II 960.9 Decreased Phospholipid Remodelling May Increase DHA Bioavailability in Maternal Blood During Pregnancy. D. Chalil, A. Chalil, K.D. Stark. University of Waterloo, Canada.
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NUTRITION TUESDAY C121 II 960.10 Factors Associated with Mid Upper Arm Circumference in Pregnant Women in Banke, Nepal. S. Ghosh, J. Andrews Trevino, D. Davis, R. Shrestha, A. Bhattarai, A. KC, A. Pokharel, B. Dulal, S. Gurung, K. Paudel, K. Baral, P. Webb. Tufts, Helen Keller International, Nepal, Feed the Future Innovation Lab, Nepal, KANTI Children’s Hospital, Nepal and Patan Academy of Medical Sciences, Nepal. C122 II 960.11 Do Cord Serum Ferritin Concentrations Serve as an Index of Neonatal Iron Status? K.M. Delaney, R.K. Fleming, R. Guillet, R. Queenan, E.K. Pressman, K.O. O’Brien. Cornell University, Saint Louis University and University of Rochester.
961. HEALTH DISPARITIES AND PROMOTING HEALTH IN DIVERSE POPULATIONS Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C123 I 961.1 Evaluation of Pregnancy Outcomes Among Food Insecure Women Attending the Montreal Diet Dispensary Program. V. Menard, H. Weiler. McGill University, Canada and Montreal Diet Dispensary, Canada. C124 II 961.2 Exploring the Food Choices of Muslim Arab Immigrants in Canada. R. Aljaroudi. School of Public Health and Health Systems at University of Waterloo, Canada. C125 I 961.3 Socioeconomic Position and Disparities in Cardiovascular Health Response Following the E-Mechanic Exercise Intervention. C.A. Myers, S.T. Broyles, T.S. Church, C.K. Martin. Pennington Biomedical Research Center. C126 II 961.4 Psychosocial Stressors Are Associated with Worsened Severity of Metabolic Syndrome Independent of Lifestyle Factors Among African Americans in the Jackson Heart Study. M.I. Cardel, M.D. DeBoer, M. Sims, S. Musani, A. Dulin-Keita, M.J. Gurka. University of Florida, University of Virginia, University of Mississippi and Brown University. C127 I 961.5 Adequacy and Sources of Total Daily Water and Liquid Drinks by Non-Pregnant/Non-Lactating (NPNL) Women Across the Socio-Geographic Spectrum of Guatemala. R. Campos, L.A. Diaz-Jereda, M. Vossenaar, N.W. Solomons. CeSSIAM, Guatemala. C128 II 961.6 Food Experiences of Brazilian Immigrants in Lowell, MA. J. Nelson-Peterman, S. Modarresi Ghavami, E.T. Carbone, L.S. Cordeiro. Framingham State University, Brockton Hospital and University of Massachuestts Amherst. C129 I 961.7 Between Tradition and Health: Comparing Community and Expert Perceptions of Hispanic Caribbean Diets in New York City. M. Fuster, E. Bank. CUNYBrooklyn College. C130 II 961.8 Acculturation and Hispanic-Heritage Mothers’ Perception of Child Weight as Related to Child Feeding Practices. V. Luna, E. Villegas, B. Hannon, A. Hammons, M. Cruz-Santiago, A. Wiley, M. Teran-Garcia. University of Illinois at Urbana-Champaign and California State University. C131 I 961.9 Weight-Related Behaviors and Cognitions: Differences Between Latino and White Families with Young Children. C. Delaney, V. Quick, C. Byrd-Bredbenner. Rutgers University.
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C132 II 961.10 More Popular in the Pantry: Social Norm Signage Shifts Food Pantry Patrons to Healthier Foods. B. Wansink, H. Bhana. Cornell University and Columbia University. C133 I 961.11 Developmental Evaluation of a Novel Food Security Strategy to Support Pregnant and Postpartum Newcomer Women in Edmonton. M. Quintanilha, M. Mayan, S. Ngo, Y. Chiu, R. Bell. University of Alberta, Canada and Multicultural Health Brokers Cooperative, Canada. C134 II 961.12 Effect of Vitamin D3 Supplementation on Blood Pressure in Hispanics with Type 2 Diabetes. G.G. Zarini, J. Exebio, J.A. Vaccaro, M. McLean, S. Ajabshir, F.G. Huffman. Florida International University. C135 I 961.13 Employment Status Among the Poor and Its Relationship with Diet. E.E. Calloway, N.A. Baryeh, M. Helmick, K.L. Stern, H.E. Fricke, T. Barnard, J.L. Hill, J.A. Dake, A.L. Yaroch. The Gretchen Swanson Center for Nutrition, The University of Toledo and University of Nebraska Medical Center. C136 II 961.14 Analysis of Food Shopping Practices of South Asian Men and Women in the U.S. Z. Qamar, W.A. McIntosh. Texas A&M University. C137 I 961.15 Nutrition Knowledge-Attitude-Behavior Is Inversely Associated with the Risk of Obesity Among Staff Working in Michigan Migrant and Seasonal Head Start Centers. S. Song, N. Farabi, K. Moorhead Hill, A.R. Knox, Y. Lim, I. Galdamez, A. Aguilar-Corrales, W.O. Song. Michigan State University and Michigan State University Extension. C138 II 961.16 Diabetes Diagnosis Status Impacts Dietary Quality Among Hispanic Women with or at Risk for Type 2 Diabetes. S. Vega-López, N.M. Lindberg, M. Leo, M. Arias-Gastélum, M. Petrovic, E. Shuster, E.S. LeBlanc, V.J. Stevens, R.T. Meenan. Arizona State University and Kaiser Permanente Center for Health Research. C139 I 961.17 An Evaluation of US RDNs’ Knowledge of Islamic Dietary Guidelines. K.A. Isberg, J. Kloubec, M. Thall, P. Savery, A. Kazaks. Bastyr University. C140 II 961.18 Association of Serum 25-Hydroxyvitamin D, Quantitative Insulin Sensitivity Check Index (QUICKI) and Homeostatic Model Assessment Indexes of Insulin Resistance (HOMA1-IR and HOMA2-IR) Among Three Ethnic Groups. S. Ajabshir, J.C. Exebio, G.G. Zarini, F.G. Huffman. Florida International University. C141 I 961.19 Culturally Relevant Diabetes Education Program Viewed Favorably by Rural-Residing Latinos. M. Keane, M. Bahl, S.L. Francis. Iowa State University. C142 II 961.20 Modeling How Prognosis Levels of Kidney Disease in Diabetic African American Males Relate to Factors of Fresh Food Availability and Frequency of Communication with Healthcare Providers. C.T. HopkinsHarrington, E.M. Ongeri, S.H. Harrison. North Carolina A&T State University. C143 I 961.21 Maternal Health Matters—The Home Food Environment and Cardiometabolic Risk Factors. S.K. Hibbs-Shipp, S.L. Johnson, R. Boles, T. Nelson, M. Wdowik, L.L. Bellows. Colorado State University, University of Colorado Denver and Anschutz Medical Campus. C144 II 961.22 Emotional Eating Is Associated with Intake of Energy-Dense Foods in Latinos. A.A. Lopez-Cepero, C. Frisard, S. Lemon, M. Rosal. University of Massachusetts Medical School.
TUESDAY NUTRITION C145 I 961.23 Low Health Literacy Hinders Accurate Perceptions of Body Weight Among Mexican Women. L. Aguayo, E. Sandberg, A. Schwingel, A. Wiley. University of Illinois at Urbana-Champaign and Northwestern University. C146 II 961.24 The Needs of Nutrition and Physical Activity Education for Staff of Michigan Migrant and Seasonal Head Start Centers. A.R. Knox, Y. Lim, S. Song, K. MoorheadHill, N. Farabi, W. Song. Michigan State University. C147 I 961.25 Young Adult Males and Regional Appalachian Differences in Dietary Patterns Across U.S. Universities. C.M. Charlier, M.L. Barr, S.E. Colby, G. Greene, C. Bryd-Bredbenner, M.D. Olfert. West Virginia University, University of Tennessee, University of Rhode Island and Rutgers University. C148 II 961.26 Perspectives of a Middle-Aged Appalachian Population Regarding Healthful Eating and Weight Management. A. Gousios, S. Thompson, M.V. Marra. West Virginia University.
962. FOOD ENVIRONMENT Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C149 I 962.1 Association of Individual and Neighborhood Factors with Home Food Availability: Evidence from the National Health and Nutrition Examination Survey (NHANES). W. Chai, J.X. Fan, M. Wen. University of NebraskaLincoln and University of Utah. C150 II 962.2 How Diet Quality in Older Adults Relates to Meal Location, Eating with Others, and Electronic Screen Use. R.W. Korycinski, H.R. Bowles, K.W. Dodd, Y. Park, F.E. Thompson, A.F. Subar. National Cancer Institute and Washington University School of Medicine in St. Louis. C151 I 962.3 Dietary Differences Between Vegetarian and Omnivore College Students. S. Bunawan, D.R. Edens, A. Goardon, B. Burns-Whitmore. California State Polytechnic University at Pomona. C152 II 962.4 East Feliciana Parish LA Has Limited Availability of Nutritional Food Sources Which May Be Associated with Obesity and Limit Individuals’ Ability to Meet Dietary Recommendations. T.D. Alexis, C.E. O’Neil, M. Cater, D. Holston. Louisiana State University and Louisiana State University AgCenter. C153 I 962.5 Mineral Content of Eggs from Backyard Chickens Reared Under Differing Conditions. L.E. HeflinMorgan, S.A. Plunkett, E. King, L.K. Johnson, D.J. Soldat, S.K. Raatz. USDA, ARS, University of Wisconsin-Madison and University of Minnesota. C154 II 962.6 Brain Response to Food Brands Is Positively Associated with Laboratory Intake at a Branded Meal in Children. T.D. Masterson, M. Bermudez, W. Stein, E. Beidler, L. English, K.L. Keller. The Pennsylvania State University. C155 I 962.7 Weight-Related Aspects of the Home Environment of Latino Families. C. Delaney, V. Quick, C. ByrdBredbenner. Rutgers University. C156 II 962.8 The Effect of Family Affluence on WeightRelated Cognitions of the Home Environment. C. Delaney, V. Quick, K. Eck, C. Byrd-Bredbenner. Rutgers University.
C157 I 962.9 Delta Healthy Sprouts: Participants’ Diet and Food Environment at Baseline. M.H. Goodman, J.L. Thomson, A.S. Landry, L.M. Tussing-Humphreys. USDA Agricultural Research Service, University of Central Arkansas and University of Illinois at Chicago. C158 II 962.10 Foreign Weight: New Food Environments as Weight Change Estimates for Expats. B. Missbach, J. König, B. Wansink. Cornell University and University of Vienna, Austria. C159 I 962.11 Effect of Acid Concentration on the Yield of Ethanol from Cassava Waste Using Baker’s Yeast. O.T. Oyelola, I.O. Ajiboshin, I.O. Banjoko. Yaba College of Technology, Nigeria. C160 II 962.12 Vegan “Decoy” Entrées Lead Cafeteria Diners to Take Healthier Other Foods. H. Tran, B. Wansink, K.I. Karevold. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C161 I 962.13 Development and Validation of a B.E.A.N. Survey for College Students. M. Sowers, S. Colby, C. Allison, W. Zhou. University of Tennessee. C162 II 962.14 Factors Associated with Vending Machine Snacks Choices in Young Adults. P. Rusmevichientong, E. Navajas, J. Jaynes, S. Kazemi, A. McEligot, S. Mitra. California State University Fullerton. C163 I 962.15 Adaptation and Validation of the Nutrition Environment Measures Survey in Stores (NEMS-S) in Costa Rica. F. Golfin, C. Murillo, M.L. Jensen, E.A. Frongillo. University of Costa Rica, Costa Rica and University of South Carolina. C164 II 962.16 Development of an Assessment Tool to Measure the Latino Market Nutrition Environment. J. Baier, D. Winham, S. Palmer, C. Voss. Iowa State University and Iowa Dept. Public Health. C165 I 962.17 Effect of Chebulic Acid on Alveolar Epithelial to Mesenchymal Transition in Response to the Urban Particulate Matter. H. Lee, M. Pyo, S. Yang, K. Lee. Korea University, Republic of Korea. C166 II 962.18 Food Environmental Factors Related to Dietary Intake According to Residential Areas in Older Adults Residing in Rural Areas. K. Kim, S. Kim, J. Shim, J. Hwang. Dankook University, Republic of Korea, Sangmyung University, Republic of Korea, Daejeon Univesrity, Republic of Korea. C167 I 962.19 The Cost of a Healthy Diet in Trinidad and Tobago. K. Rocke, S. Nichols, P. Prout, N. Dalrympe. The University of The West Indies, Trinidad and Tobago. C168 II 962.20 Healthy Foods and Small Stores: Customer Perspectives from Rural Maryland. M.J. Shapiro, R.A. Neff, P.J. Surkan, L.J. Cheskin, J. Gittelsohn. Johns Hopkins Bloomberg School of Public Health. C169 I 962.21 Food Group Intakes of Self-Selected U.S. Diets with High and Low Carbon Footprints. A. WillitsSmith, M. Heller, R. Meyer, D. Rose. Tulane University and University of Michigan. C170 II 962.22 Are Commercially Processed GlutenFree Products “Healthy,” and Nutritionally Superior to Similar Gluten-Containing Products? J.K. Ahuja, Y. Li, B. Showell, Q. Nguyen, P.R. Pehrsson. USDA-ARS-BHNRC_Nutrient Data Laboratory and USDA-Food and Nutrition Service. C171 I 962.23 Undergraduate Student Perceptions of the Food Environment at a University Commuter Campus. M. Reznar, D. Bohn. Oakland University and University Of Michigan.
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963. PERSONALIZED NUTRITION Poster (Sponsored by: Medical Nutrition Council) Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C172 I 963.1 Corporate Wellness Inclusion of Registered Dietitian Nutritionists: Providing Personalized Nutrition Counseling to Improve Nutrition and Lifestyle Factors. K. Hicks, K.S. Black, K.R. Yoder Latortue. Texas A&M University and Family Food LLC. C173 II 963.2 Development of a Dynamic MealEquivalent Menu Method for Personalized Nutrition Intervention Programs in Obese Population. A.T. Limon-Miro, V. LopezTeros, H. Astiazaran-Garcia. Centro de Investigacion en Alimentacion y Desarrollo (CIAD), Mexico and University of Sonora, Mexico. C174 I 963.3 BMI Z-Score Improves After 24 Months of Precision Ketogenic Therapy in Patients with Abnormal Baseline BMI Z-Score. J. Lukosaityte, H.J. Allen, D.J. Lennon, P.R. Borum. University of Florida. C175 II 963.4 Who Benefits Most from Personalized Nutrition? Findings from the Pan-European Food4Me Randomized Controlled Trial. K.M. Livingstone, C. CelisMorales, J. Mathers. Newcatle University, United Kingdom and Newcastle University, United Kingdom. C176 II 963.5 Improvements in Arterial Stiffness Due to Bean and Pea Consumption Are Determined by Metabolic State. P. Zahradka, D. Perera, A. Wilson, M. Wiecek, R. Bell, C.G. Taylor. St. Boniface Research Centre, Canada, University of Manitoba, Canada and University of Alberta, Canada.
964. NUTRITIONAL IMMUNOLOGY AND INFLAMMATION Poster (Sponsored by: Nutritional Immunology and Inflammation RIS) Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C177 I 964.1 Effect of Prepartum Adiposity and Lipolysis on Gestational and Postnatal Adipose Tissue Inflammation and Immune Cell Infiltration. C. StriederBarboza, J. de Souza, A.L. Lock, G. Contreras. Michigan State University. C178 II 964.2 The Differential Immunomodulatory Activities of Arginine, Citrulline, and Glutamine on Leukocytes and Splenocytes in Rats with Hemorrhagic Shock and Resuscitation. H. Lo, Y. Li, C. Lee. Fu Jen Catholic University, Taiwan and Children’s Hospital of China Medical University, Taiwan. C179 I 964.3 Glutamine Modulates Cytokines Gene Expression in a Dose and Time Dependent Manner. D.C. de Oliveira, B.H. Horwitz, R.A. Fock. University of São Paulo, Brazil and Brigham and Women’s Hospital.
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C180 II 964.4 The Leucine Metabolic Pathway Is Differentially Regulated by c-MYC and NFAT in T Cells and Their Cancerous Counterpart EL-4 Lymphoma Cells. M. Brenner, A. Torres, S. Hutson, E. Ananieva. Des Moines University, Mercy College of Health Sciences and Virginia Tech. C181 I 964.5 In Vitro Hypoallergenic Potential of Peanut Protein-Polyphenol Aggregate Particles. N.J. Plundrich, R.R. Bansode, L.L. Williams, M. Lila. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina Research Campus, North Carolina Agricultural and Technical State University, Center for Excellence in PostHarvest Technologies and North Carolina Research Campus. C182 II 964.6 B Cell Cytokine Secretion and Antibody Production Are Impaired Upon BCR/TLR9 Stimulation in Obese Subjects. R. Kosaraju, W. Guesdon, S. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes & Obesity Institute and East Carolina University. C183 I 964.7 Obesity Suppresses B Cell Development and Impairs Antibody Production Upon Antigen Challenge. M. Crouch, W. Guesdon, S. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute and East Carolina University. C184 II 964.8 Guanylate Binding Protein 1 Regulates Metabolic Reprograming and Polarization of Macrophages. X. Qiu, H. Guo, X. Chen. University of Minnesota-Twin Cities. C185 I 964.9 Differential Effect of Vitamin D Supplementation on Natural Killer Cell Activity in Normal and Obese Mice. G. Lee, K. Cha, C. Park, S. Lee, M. Pae, S. Han. Seoul National University, Republic of Korea, Chungbuk National University, Republic of Korea. C186 II 964.10 Characteristics of and Predictors of Inflammation Among 6–23 Month Old Children in Nepal. V. Akelo, R.D. Whitehead; Jr., Z. Mei, Chitekwe, Dahal, Paudyal, Pokharel, Y. Addo, Jefferds. Centers for Disease Control and Prevention (CDC), UNICEF, Nepal, Ministry of Health and Population and Nepal, Nepal. C187 I 964.11 Characterizing the Inflammatory Response to a High-Fat Meal in Healthy Adults: A Systematic Review. S.R. Emerson, S.P. Kurti, C.A. Harms, M.D. Haub, T. Melgarejo, C. Logan, S.K. Rosenkranz. Kansas State University. C188 II 964.12 Dietary Long-Chain PUFAs Enrich Porcine Alveolar Macrophages and Alter Prostaglandin E2 Production Following LPS Challenge. K.R. Walter, L. Xi, S.K. Jacobi, D. Esposito, J. Odle. North Carolina State University and Ohio State University. C189 I 964.13 Enhancing Methionine Supply Alleviates Inflammation and Oxidative Stress and Improves Liver Function During the Peripartum Period in Dairy Cows. F. Batistel, J. Arroyo, C.M. Garces, A. Bellingeri, E. Trevisi, C. Parys, B. Saremi, J. Loor. University of Illinois, Università Cattolica del Sacro Cuore, Italy and Evonik Nutrition & Care GmbH, Germany. C190 II 964.14 A Cell-Based Approach to Quantifying Endotoxin in Human Plasma Samples. K.L. Fritsche, J. Browning, P. Eichen, V.V. Mossine. University of Missouri. C191 I 964.15 Ingestion of Megalo-Type Isomaltoglucosaccharides Amelioraties LipopolysaccharideInduced Acute Liver Injury in Rats. G. Joe, T. Iizuka,Y. Fujimoto, A. Kimura, H. Hara, S. Ishizuka. Hokkaido University, Japan, Nihon Shokuhin Kako Co. and Ltd., Japan.
TUESDAY NUTRITION C192 II 964.16 Post-Resistance Exercise Ingestion of Amino Acids Attenuates the Initial Increase in Plasma TNFα and TNFR1 Expression on Monocyte Subpopulations. A.J. Wells, J. Hoffman, A. Jajtner, A. Varanoske, D. Church, A. Gonzalez, J. Townsend, C. Boone, K. Baker, K. Beyer, G. Mangine, L. Oliveira, D. Fukuda, J. Stout. University of Central Florida, Kent State University, Hofstra University, Lipscomb University, Kennesaw State University and University of Chicago Medicine. C193 I 964.17 Higher Leptin Levels Are Associated with Obesity and Slower HIV Disease Progression. S.S. Martinez, A. Campa, R. Marlink, J. Makhema, S. Moyo, F. Huffman, M.K. Baum. Florida International University, Harvard University and Botswana-Harvard Partnership, Botswana. C194 II 964.18 Epigallocatechin-3-Gallate (EGCG) Inhibits IL-6-Induced CRP Synthesis and Ameliorates Adiponectin Expression in Hep3B Cells. B. Madarampalli, S. Ahmed. Washington State University. C195 I 964.19 The Vegetarian Diet and Chronic Inflammation. M. Morgan-Bathke, M. Jensen. Mayo Clinic and Viterbo University. C196 II 964.20 Vitamin D Status and Anthropometric Measurements of Children with Juvenile Idiopathic Arthritis Compared to Healthy Children Using the Canadian Health Measures Survey. S.L. Finch, E.L. Rezaei, S.J. Whiting, A.M. Rosenberg, H. Vatanparast. University of Saskatchewan, Canada. C197 I 964.21 Vitamin C and Zinc Concentrations Are Associated with Lower Risk of Inflammation in a SchoolAged Population of Children in Rural Mexico. O.P. Garcia, K. Torres, G.A. Zavala, M. Camacho, D. Ronquillo, J.L. Rosado. Universidad Autonoma de Querétaro, Mexico and VU Amsterdam University, Netherlands. C198 II 964.22 Gender Dictates the Relationship Between Serum Cholesterol and White Blood Cell Counts in NHANES 1999–2004. C.J. Andersen, T.M. Vance. Fairfield University and The State University of New York College at Plattsburgh. C199 I 964.23 Statin Usage Is Inversely Associated with Prevalence of Autoantibodies in Women, But Not Men. C.J. Andersen, T.M. Vance. Fairfield University and The State University of New York College at Plattsburgh. C200 II 964.24 Docosahexaenoic Acid Improves the Decrement in Antibody Production Upon Influenza Infection of Obese Mice Through the Production of Pro-Resolving Lipid Mediators. W. Guesdon, M. Crouch, R. Kosaraju, M. Armstrong, N. Reisdorph, S.R. Shaikh. East Carolina University and University of Colorado. C201 I 964.25 Protective Effects of Fermented Milk with Selected Probiotics Against Acute Upper Respiratory Tract Infections by Enhancement of Immunity of the Elderly: An Open-Label Trial. F. Pu, Y. Guo, F. He, H. Zhu, S. Wang, X. Shen, M. He, M. Li. West China School of Public Health, Sichuan University, People’s Republic of China, Shijiazhuang Junlebao Dairy Co., Ltd., People’s Republic of China. C202 II 964.26 Cranberry Beverage Consumption Reduces Antibiotic Use for Clinical Urinary Tract Infection in Women with a Recent History of Urinary Tract Infection. K.M. Nieman, M.R. Dicklin, A.L. Schild, K.L. Kaspar, C. Khoo, L.H. Derrig, K. Gupta, K.C. Maki. Midwest Biomedical Research—Center for Metabolic and Cardiovascular Health, Biofortis Innovation Services, Ocean Spray Cranberries and Boston University School of Medicine and VA Boston Healthcare System.
965. THE MICROBIOME AND NUTRITION Poster Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C203 I 965.1 Clinical Evaluation of the Effect of a Fermentate from Yeast on Digestive Comfort, Stool Parameters and Prebiotic Modulation of the Gut Microbiota. L. Robinson, I. Pinheiro, A. Verhelst, E.H. Sanabria, P. Abbeele, S. Possemiers. Embria Health Sciences, ProDigest, Belgium and Ghent University, Belgium. C204 II 965.2 β2-1 Fructan Supplementation in Healthy Adults Elicits Host-Specific Bacterial Responses But Does Not Support a Defined Health Benefit. S. Brooks, S. Clarke, G. Inglis, L. Yanke, J. Green, N. Petronella, D. Ramdath, P. Bercik, J. Green-Johnson, M. Kalmokoff. Health Canada, Canada, University of Ontario Institute of Technology, Canada, Agriculture and Agri-Food Canada, Canada and McMaster University, Canada. C205 I 965.3 lactobacillus Reuteri Induce Antimicrobial Peptide Exprssion in Mice Gut Crypt Through microbiota Released Extracellular Dna. J. Sun, C. Qi, X. Wang, G. Le, H. Xiao. Jiangnan University, People’s Republic of China, and University of Massachusetts. C206 II 965.4 Lactobacillus paracasei N1115 Can Alter Lipid Metabolismin of High-Fat Diet Fed SD Rats. F. Pu, Y. Guo, S. Wang, H. Zhu, X. Shen, Z. Wu, M. Li, F. He. West China School of Public Health, Sichuan University, People’s Republic of China, Shijiazhuang Junlebao Dairy Co., Ltd., People’s Republic of China. C207 I 965.5 Bacterial Fermentation End-Products Are Related to Hepatic Steatosis Among Overweight and Obese Adults. S.V. Thompson, J.W. Berndt, C.G. Edwards, J.W. Erdman Jr., N.A. Khan, W.D. O’Brien Jr., H.D. Holscher. University of Illinois at Urbana-Champaign. (138.6) C208 II 965.6 Effects of Diet-Induced Obesity and Estrogen on the Female Rat Fecal Microbiome. P.A. Ozark, S.N. Blythe, N. Toporikova, G.B. Whitworth. Washington and Lee University. (138.2) C209 I 965.7 Effects of Sun-Dried Raisin Consumption on Gut Microbiota Composition. A. Wijayabahu, S. Waugh, M. Ukhanova, A. Caraughi, V. Mai. University of Florida, Sun-Maid Growers of CA, and University of Florida. C210 II 965.8 Microencapsulation of Lactobacillus salivarious Li01 for Enhanced Storage Viability and Targeted Microbiome Delivery. M. Yao, B. Li, H. Xiao, L. Li. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Ce, People’s Republic of China, Department of Food Science, University of Massachusetts and Amherst. C211 I 965.9 High-Fat Diet Increases Clostridium Clusters XIVa in Obese Rodents. N. Jiao, S.S. Baker, C.A. Nugent, M. Tsompana, L. Guan, Y. Wang, M.J. Buck, R.J. Genco, R.D. Baker, R. Zhu, L. Zhu. Tongji University, People’s Republic of China, SUNY Buffalo, Beijing University of Chinese Medicine, People’s Republic of China.
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NUTRITION TUESDAY C212 II 965.10 Human Gut Microbiome Response Induced by Fermented Dairy Product Intake. O. Volokh, A. Tyakht, Y. Berezhnaya, P. Nesterova, J.V. St. Peter. PepsiCo Global R&D, Russian Federation, Knomics, Russian Federation and PepsiCo Global R&D. C213 I 965.11 Efficacy of Bifidobacterium animalis ssp. lactis HN019 on Cellular Immune Function in Healthy Elderly: A Systematic Review and Meta-Analysis. L. Lehtoranta, L. Miller, M. Lehtinen. DuPont Nutrition&Health, Finland, Miller Scientific Consulting and Inc. C214 II 965.12 Impact of Long-Term Dietary Patterns and Short-Term Nutrient Intake on the Gut Microbiota of Children 4 to 8 Years of Age. K. Berding, S. Donovan. University of Illinois. C215 I 965.13 Effects of Prebiotic Inulin-Type Fructans on Blood Metabolite and Hormone Concentrations and Fecal Microbiota and Bile Acids in Overweight Dogs. C. Alexander, T. Liu, S. Devendran, S. Theis, J.M. Ridlon, J.S. Suchodolski, M.R. de Godoy, K.S. Swanson. University of Illinois at Urbana-Champaign, Beneo GmbH, Germany and Texas A&M Univsersity. C216 II 965.14 PCB126 Exposure Modulates Gut Microbial Fermentation of the Dietary Fiber Inulin. J.B. Hoffman, M. Flythe, B. Hennig. University of Kentucky. C217 I 965.15 Obese Prone CD Rats Robustly Ferment Resistant Starch (RS) with No Increased Weight and Fat Accretion. D. Obanda, R. Page, J. Guice, E. Kyereh, A. Raggio, G. Tuuri, C. Husseneder, R. Martin, B. Marx, D. Coulon, R. Stout, M. Keenan. LSU AgCenter, LSU A&M and LSU Veterinary School. (138.3) C218 II 965.16 Diet Differentially Impacts Gastrointestinal Integrity, Fecal β-Glucuronidase Activity, and Longitudinal Fecal Microbial Communities of C57BL/6J Mice in Response to Ovariectomy-Induced Obesity. T. Liu, E.R. Nelson, M.A. Wallig, A.P. Bhatt, S.J. Pellock, C. Lin, M.R. Redinbo, K.S. Swanson. University of Illinois at UrbanaChampaign and University of North Carolina at Chapel Hill. (138.5) C219 I 965.17 Antibiotics Administration Altered Microbiota Composition After Knockdown, Donor Transplant and Chow Diet in Lean Zucker Diabetic Fatty (LZDF) Rats. R. Page, J. Guice, D. Carvajal-Aldaz, A. Raggio, D. Welsh, C. Taylor, M. Luo, E. Blanchard, C. Husseneder, G. Tuuri, B. Marx, R. Stout, R. Martin, A. Bruce-Keller, D. Coulon, M. Keenan. LSU AgCenter, Facultad Ciencias de la Vida, Ecuador, LSU Health Sciences Center, LSU A&M, LSU Veterinary School and Pennington. (138.4) C220 II 965.18 Broccoli Consumption Impacts the Human Gastrointestinal Microbiota. J.L. Kaczmarek, C.S. Charron, J.A. Novotny, E.H. Jeffery, H.E. Seifried, S.A. Ross, K.S. Swanson, H.D. Holscher. University of Illinois at UrbanaChampaign, USDA and NCI/NIH. C221 I 965.19 Dietary Supplementation with Raspberry Whole Fruit Modifies the Relative Abundance of Fecal Microbial Communities in Obese Diabetic (db/db) Mice. G. Noratto, J. Garcia-Mazcorro, B.P. Chew, S.U. MertensTalcott. Texas A&M University and Universidad Autónoma de Nuevo León, Mexico. C222 II 965.20 Human Gastrointestinal Microbes Vary Throughout the Day. J.L. Kaczmarek, H.D. Holscher. University of Illinois at Urbana-Champaign.
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C223 I 965.21 The Relationship Between Abnormal Metabolic Status and the Breastmilk Microbiome in Women Three Months Post-Partum. L. LeMay-Nedjelski, S.H. Ley, A.J. Hanley, A. Stintzi, J. Butcher, P.W. Wang, J.K. Copeland, S. Unger, D.L. O’Connor. University of Toronto, Canada, Hospital for Sick Children, Canada, Brigham and Women’s Hospital and Harvard Medical School, University of Ottawa, Canada, The Hospital for Sick Children, Canada and Mount Sinai Hospital, Canada. C224 II 965.22 The Influence of Habitual Food Intake on Fecal Microbiota in Mexican School-Age Children. J.N. Martinez-Medina, B.E. López-Contreras, E. OcampoMedina, R. Villarruel-Vazquez, H. Villamil-Ramirez, P. LeonMimila, P. Grey-Lievanos, S. Canizales-Quinteros, S. MoranRamos. National Institute of Genomic Medicine, Mexico and CONACYT- National Institute of Genomic Medicine, Mexico. C225 I 965.23 Pre-Hispanic Mexican Diet Reduced Dysbiosis and Inflammation Mediated by LPS in Diet Induced Obesity. A. Avila-Nava, M. Aguilar-López, M. Sanchez-Tood, A.R. Tovar, N. Torres. Instituto Nacional de Ciencias Médicas y Nutrición, Mexico. C226 II 965.24 A Diet Defined by Its Content of Bovine Milk Exosomes Alters the Composition of the Intestinal Microbiome in C57BL/6 Mice. F. Zhou, H.A. Paz, M. Sadri, S.C. Fernando, J. Zempleni. University of Nebraska-Lincoln. C227 I 965.25 Human Breast Milk Microbiota Is Influenced by Maternal Age and Bmi, Stage of Lactation and Infant Feeding Practices C. Li, E. Gonzalez, N.W. Solomons, M.E. Scott, K.G. Koski. McGill University, Canada, McGill University and Genome Quebec Innovation Centre, Canada, CeSSIAM, Guatemala and Center for Host-Parasite Interactions, Canada. C228 II 965.26 Iron in Micronutrient Powder (MNP) May Adversely Affect the Gut Microbiome in Kenyan Infants. M. Tang, D.N. Frank, A.E. Hendricks, D.L. Culbertson, F. Esamai, N.F. Krebs. University of Colorado Anschutz Medical Campus, University of Colorado Denver, Washington University in St. Louis and Moi University School of Medicine, Kenya. C229 I 965.27 Glucevia®, a Fraxinus angustifolia Vahl Extract, Is Able to Modify the Gut Microbiota Composition and Those Effects Are Correlated with Steatosis Severity in Obese and Diabetic Mice. P. Fança-Berthon, E. Riant, A. Waget, L. Falcao, A. Bily, M. Roller, R. Burcelin, P. Gourdy. Naturex, France and Inserm UMR 1048/I2MC, Toulouse University, France, Diabetology department and CHU de Toulouse, France. C230 II 965.28 Michigan Cohorts to Assess the Associations of Maternal Pre-Pregnancy Obesity with Pregnancy and Infant Gastrointestinal Microbial Communities. S.S. Comstock, K.Y. Sugino. Michigan State University. C231 I 965.29 The Reciprocal Interactions Between Red Raspberry Polyphenols and Gut Microbiome Composition: Preliminary Findings. X. Zhang, A. Sandhu, K.M. Schill, I. Edirisinghe, B. Burton-Freeman. Illinois Institute of Technology and U.S. Food and Drug Administration. C232 II 965.30 Modulation of Gut Microbiota by Dietary Pomegranate Extract and Inulin in Mice Fed an Obesogenic Diet. S. Zhang, J. Yang, S.M. Henning, R. Lee, M. Hsu, E. Grojean, R. Pisegna, A. Ly, D. Heber, Z. Li. Qilu University of Technology, People’s Republic of China, and University of California Los Angeles.
TUESDAY NUTRITION C233 I 965.31 Host Diabetes Status Is the Major Regulator of Gut Microbiome in the UCD-T2DM Rat. B. Piccolo, J. Graham, U. Wankhade, I. Nookaew, K. Shankar, P. Havel, S. Adams. Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, University of California at Davis. (138.1) C234 II 965.32 Assessing the Maternal Transfer of Lactobacilli to the Intestine of CD-1 Murine Fetuses. A. Hashemi, K. Johnson-Henry, A. Taibi, S.E. Stinson, T. Tompkins, P.M. Sherman, E.M. Comelli. University of Toronto, Canada, Hospital for Sick Children, Canada and Lallemand Health Solutions Inc, Canada. C235 I 965.33 in Vitro Assessment of Prebiotic Potential of Culinary Spices. Q. Lu, P. Summanen, R. Lee, J. Huang, S. Henning, D. Heber, S. Findgold, Z. Li. UCLA David Geffen School of Medicine and VA Medical Center Los Angeles. C236 II 965.34 Gastrointestinal Microbiota and Cognitive Function in Adult Females. A.M. Taylor, C.G. Edwards, N.A. Khan, H.D. Holscher. University of Illinois at Urbana-Champaign. C237 I 965.35 Correlations of Abdominal Fat and Colonic Sulfidogenic Bacteria in African Americans and NonHispanic Whites with Newly Diagnosed Colorectal Cancer. S.L. Gomez-Perez, C. Yazici, P.M. Wolf, C. Braunschweig, R. Xicola, X. Llor, N. Ellis, L. Tussing-Humphreys, E.A. Mutlu, R.H. Gaskins. Rush University Medical Center, University of Illinois Hospital & Health Sciences System, University of Illinois at Urbana-Champaign, University of Illinois at Chicago, Yale University and University of Arizona. (138.7) C238 II 965.36 Dairy Consumption, LCT-13910C>T Genotype and the Plasma Proteome. O. Alharbi, A. ElSohemy. University of Toronto, Canada. C239 I 965.37 Investigating the Links Between Habitual Diet, the Gastrointestinal Microbiota, and Cardiovascular Disease Risk Factors in Healthy Weight, Overweight, and Obese Men and Women. M.A. Bailey, J.W. Beals, S.K. Skinner, S.A. Paluska, N.A. Burd, H.D. Holscher. University of Illinois at Urbana Champaign. C240 II 965.38 Probiotics for Weight Loss: Assessing the Evidence. C.M. Cook, D.J. Liska, L.B. Mantilla. Biofortis. C241 I 965.39 Probiotic Lactobacillus reuteri (ATCC23272) Attenuates the Effects of Repeated Social Defeat on the Colonic Epithelial Cell Transcriptome in C57BL/6 Mice. M.T. Bailey, A.R. Mackos. Nationwide Children’s Hospital, The Ohio State University and College of Medicine. C242 II 965.40 Effects of a 6 Week Aerobic Exercise Intervention on Gut Bacterial Metabolites in Lean and Obese Adults. L. Mailing, J. Allen, G. Niemiro, J. Cohrs, H. Holscher, M. De Lisio, J. Woods. University of Illinois at Urbana-Champaign. C243 I 965.41 Microbiome Impact from a Nutrition Intervention in Young Adults: FRUVEDomics Pilot Study. O.A. Famodu, A.M. Infante, C.C. Cuff, I. Holaskova, I.M. Olfert, M.T. Downes, P.J. Murray, J.W. McFadden, S.E. Colby, J. Morrell, M.D. Olfert. West Virginia University, University of Tennessee and University of New Hamshire. C244 II 965.42 Exercise Effects on Fecal pH During a Period of Excess Dietary Fat and Sugar Consumption. L.F. Castillo, W.J. Tucker, S.S. Angadi, G.A. Gaesser, C.M. Whisner. University of Texas at El Paso and Arizona State University. (138.8)
C245 I 965.43 Association Between Gut Microbiota Composition, Diet, and Anthropometric Risk Factor’s for Metabolic Disorders in Mexican Women with Food Insecurity. D.A. Ochoa-Acosta, M. Lopez-Flores, I. Osuna-Ramirez, B. Gomez-Gil, M.J. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico, CIAD and A.C., Mexico. C246 II 965.44 Four Weeks of Low Magnesium Consumption Can Dysregulate Whole-Body Metabolism and Body Composition in Mice. B. Duke, J. Challburg, A.J. Smith, G. Grover, E. Walker, J.D. Symons, T. Jalili. University of Utah and Weber State University. C247 I 965.45 Synergistic Effect of TC and PE Mixtures on Regulation of Lipolysis in 3T3-L1 Cell Differentiation. S. Park, M. Lee, H. Kwon, H. Kim, D. Lee, J. Lee. Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Republic of Korea.
966. NUTRITION AND CARDIOMETABOLIC HEALTH Poster (Sponsored by: Aging and Chronic Disease RIS) Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C248 966.1 Darker-Coloured Beans Induce Acute Vasorelaxation in Healthy Adults. J.L. Clark, A. Wilson, D. Perera, C. Taylor, P. Zahradka. Canadian Centre of Agri-Food Research in Health and Medicine, Canada and University of Manitoba, Canada. C249 966.2 Withdrawn. C250 966.3 The Antioxidant Activity of Pistachios Reduces Cardiac Tissue Injury Of acute Ischemia/reperfusion (I/r) in Diabetic Streptozotocin (Stz)-Induced Hyperglycaemic Rats. R. Di Paola, R. Fusco, E. Gugliandolo, M. Campolo, A. Carughi, G. Mandalari, S. Cuzzocrea. University of Messina, Italy and American Pistachio Growers. C251 966.4 Relationship Between Levels of Serum Methylglyoxal and Fasting Plasma Glucose in Blacks with and Without Type 2 Diabetes. P. Chantarasinlapin, G.G. Zarini, M. Barbieri, W. Wu, F.G. Huffman. Florida International University. C252 966.5 Comparing the Impact of Saturated Fatty Acids from Different Dairy Sources on LDL Particle Size Phenotype. D. Bernic, D. Brassard, M. Tessier-Grenier, E. Rajendiran, Y. She, V. Ramprasath, I. Gigleux, É. Levy, A. Tremblay, P. Jones, P. Couture, B. Lamarche. Laval University, Canada, University of Manitoba, Canada, CHU Sainte-Justine Research Center, Canada and CHU de Quebec Research Center, Canada. C253 966.6 Replacement of Refined Carbohydrates with a Combination of Egg Protein and Unsaturated Fatty Acids Improves Insulin Sensitivity in Adults with Elevated Triglycerides. K.C. Maki, O.M. Palacios, K.M. Nieman, E. Lindner, M. Bell, J. Sorce. Midwest Biomedical Research— Center for Metabolic and Cardiovascular Health and Great Lakes Clinical Trials.
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NUTRITION TUESDAY C254 966.7 Replacement of Refined Carbohydrates with a Combination of Egg Protein and Unsaturated Fatty Acids Improves the Lipoprotein Lipid Profile in Adults with Elevated Triglycerides. O.M. Palacios, K.C. Maki, K.M. Nieman, E. Lindner, M. Bell, J. Sorce. Midwest Biomedical Research— Center for Metabolic and Cardiovascular Health and Great Lakes Clinical Trials. C255 966.8 Replacement of Refined Carbohydrates with a Combination of Egg Protein and Unsaturated Fatty Acids: Effects on Lipoprotein Particle Concentrations and LDL Peak Size in Adults with Elevated Triglycerides. K.M. Nieman, K.C. Maki, O.M. Palacios, E. Lindner, M. Bell, J. Sorce. Midwest Biomedical Research—Center for Metabolic and Cardiovascular Health and Great Lakes Clinical Trials. C256 966.9 Daily Red Meat Intake Does Not Affect Improvements in Cardiovascular Disease Risk Factors Induced by Consuming the USDA’s Healthy MediterraneanStyle Eating Pattern. L.E. O’Connor, A.J. Wright, D. PaddonJones, W.W. Campbell. Purdue University and University of Texas Medical Branch. C257 966.10 Beet Juice Energy Drink Increases Nitric Oxide Bioavailability and Lowers Blood Pressure in Healthy Men. K.L. Sweazea, C.S. Johnston, B. Miller, E. Gumpricht. Arizona State University, Isagenix International and LLC. C258 966.11 Interactions Between Diet and Toxicant Exposure Lead to Increased Circulating Levels of the Cardiometabolic Disease Biomarker TMAO. M.C. Petriello, R. Charnigo, M. Pavuk, L. Birnbaum, A. Morris, B. Hennig. University of Kentucky, Centers for Disease Control and Prevention and NIH/NIEHS. C259 966.12 Relationship Between Vitamin D Status and Cardio-Metabolic Risk. J. Lopez, A. Campa, F.G. Huffman, J.P. Liuzzi, T. Li, A. Farooqi, A. Rasul, H. Simoes, L. Lantigua, S. Atlas, J. Konefal, J. Woolger, J. Lewis. Florida International University, Jackson Memorial Hospital and University of Miami. C260 966.13 Dried Beans Lower Cholesterol and Glycated Hemoglobin While Peas Lower Blood Pressure in Adults with Mild Hypercholesterolemia. R.C. Bell, P. Zahradka, M. Aliani, Y. Liang, L.J. McCargar, C. Chan, J. Ozga, S. Proctor, D. Wishart, C. Taylor. University of Alberta, Canada and University of Manitoba, Canada. C261 966.14 Effect of Barley Sprout Water Extracts on Blood Flow Improvement in Vitro. D. Lee, H. Kwon, M. Lee, S. Park, H. Kim, K. Kim, B. Choi, D. Choi, J. Lee. Kyung Hee University, Republic of Korea, Serom Co., Ltd, Republic of Korea, Research Institute of Medical Nutrition, Republic of Korea. C262 966.15 Association Between Lipid Profile and Cardiac Dysfunction in Experimental Model of Diet-Induced Obesity. A.T. Ferron, F.V. Francisqueti, F. Moreto, A. Ferraz, D. Campos, S. Bazan, C. Correa, A. Ferreira. Botucatu Medical School, Brazil. C263 966.16 Black Elderberry Extract Improves Serum HDLCholesterol and Paraoxonase-1 Activity in AtherosclerosisProne Mice. C.L. Millar, H. Winter, J. Georgelos, G.H. Norris, Y. Park, C.N. Blesso. University of Connecticut. C264 966.17 Dietary Sphingomyelin Attenuates Adipose Inflammation and Skeletal Muscle Lipid Accumulation in C57BL/6J Mice Fed an Obesogenic Diet. G.H. Norris, C. Jiang, C.M. Porter, C.L. Millar, C.N. Blesso. University of Connecticut.
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C265 966.18 Dietary Sphingomyelin Attenuates the Inflammatory Effects of an Obesogenic Diet in C57BL/6 Mice. G.H. Norris, C.M. Porter, C. Jiang, C.L. Millar, C.N. Blesso. University of Connecticut. C266 966.19 Whey and Casein in Non-Fat Dairy Milk Protect Against Postprandial Hyperglycemia-Mediated Dysregulated Arginine Metabolism in Prediabetic Adults. J.D. McDonald, C. Chitchumroonchokchai, P. Dey, J.S. Volek, K.D. Ballard, R.S. Bruno. The Ohio State University and Miami University. C267 966.20 Quantitative and Qualitative Evaluation of a Multivitamin Mineral Herbal Essential-Oil-Infused Supplement: A Pilot Clinical Trial. X. Han, T. Parker. doTERRA International and LLC. C268 966.21 Brown and Paracardial Adipose Tissue Characteristics Influenced by High Fat, High Sucrose Diet and Thermoneutral Temperature in Pregnancy. N. Dellschaft, G. Perez, P. Aldiss, L. Albustanji, H. Budge, M. Symonds. University of Nottingham, United Kingdom and Federal University of Bahia, Brazil. C269 966.22 Cashew Consumption Reduces Total and LDL Cholesterol in Mildly Hypercholesterolemic Men and Women: A Randomized, Crossover, Controlled Feeding Trial. E. Mah, J.A. Schulz, V.N. Kaden, A.L. Lawless, J. Rotor, L. Mantilla, D.J. Liska. Biofortis and Kraft Heinz Company. C270 966.23 The Effect of Honey Intake on Lipid Risk Factors: A Systematic Review and Meta-Analysis of Controlled Trials. Z. Tul-Noor, T.A. Khan, S. Blanco Mejia, R. de Souza, J.L. Sievenpiper. St. Michael’s Hospital, Canada, University of Toronto, Canada and McMaster University, Canada. C271 966.24 Tart Cherry Juice Reduces Systolic Blood Pressure in Older Adults. S.C. Chai, K. Davis, R.S. Wright, M.F. Kuczmarski, Z. Zhang, K. Lee, J. Luo. University of Delaware and Christiana Care Health System. C272 966.25 The Association Between Dietary Sulfur Amino Acid Intake and Markers of Vascular Health. P.H. Tran, E.L. Betterman, A.A. Quyyumi, D.P. Jones, T.R. Ziegler, J.A. Alvarez. Emory University. C273 966.26 Morphofunctional Changes of the Left Ventricle Induced by the Consumption of High Carbohydrate diet. K.A. Kitawara, E.A. Ribeiro, F.V. Francisqueti, A.J. Ferron, I.O. Minatel, S.G. Bazan, A.d. Ferreira, C.R. Corrêa. Botucatu Medical School—UNESP, Brazil and Botucatu Bioscience Institute—UNESP, Brazil. C274 966.27 Withdrawn. C275 966.28 Acute Effects of Hemp Protein on Post-Prandial Glycemia and Insulin Responses in Adults. R.C. Mollard, D.S. Mackay, H. Wang, A. Serrano Leon, P.J. Jones. University of Manitoba, Canada and Richardson Centre for Functional Foods and Nutraceuticals, Canada. C276 966.29 The Addition of Faba Bean Ingredients to Crackers Reduces Acute Postprandial Glycemia in Healthy Young Men. H. Fabek, R.C. Mollard, P.J. Jones, G.H. Anderson. University of Toronto, Canada and University of Manitoba, Canada. C277 966.30 Relation of Fructose-Containing Sugars with Cardiovascular Disease: A Systematic Review and MetaAnalysis of Prospective Cohort Studies. T.A. Khan, S. Blanco Mejia, R. de Souza, C.W. Kendall, J.L. Sievenpiper. University of Toronto, Canada, St Michael’s Hospital, Canada, McMaster University, Canada and University of Saskatchewan, Canada.
TUESDAY NUTRITION C278 966.31 Plasma Phospholipid Fatty Acid Profiles in Korean Adults with and Without Acute Coronary Syndrome. M.E. Walker, J. So, N.R. Matthan, E.J. Johnson, S. Han, I. Chung, A.H. Lichtenstein. Tufts University Friedman School of Nutrition, JM USDA Human Nutrition Research Center on Aging at Tufts University, Seoul National University, Republic of Korea, Ewha Womans University, Republic of Korea. C279 966.32 US and Canada Joint Effort for Dietary Reference Intake Updates. J. de Jesus, D.M. Klurfeld, C.J. Lynch, S.P. Brooks. National Heart, Lung, and Blood Institute, United States Department of Agriculture, National Institute of Diabetes and Digestive and Kidney Diseases and Health Canada, Canada. C280 966.33 The Effects of Consuming Smoothies Containing Faba Bean Ingredients on Post-Prandial Glycemia in Healthy Young Men. R.C. Mollard, H. Fabek, G. Anderson, C. Lagorse, H. Wang, P.J. Jones. University of Manitoba, Canada, Richardson Centre for Functional Foods and Nutraceuticals, Canada and University of Toronto, Canada. C281 966.34 Hemp Food Product Consumption for 4 Weeks Raises Red Blood Cell Alpha Linolenic Acid, but Not Total n-3 Polyunsaturated Fatty Acid Content, Compared to a Soybean and Sesame Control Product in Free Living Participants Who Are Overweight or Obese. D.S. Mackay, A. Cardillo, R.C. Mollard, P.J. Jones. University of Manitoba, Canada. C282 966.35 Anti-Atherogenic Effect of T0901317 Nanovesicles in THP-1 Derived Macrophages. J. Liu, C. Li, S. Wang. Texas Tech University, and Hainan University, People’s Republic of China. C283 966.36 Acute Effects of Pea Fractions in Extruded Cereals on Glycemic and Insulin Responses in Adults. A.J. Johnston, D. Omer, R.C. Mollard, D.S. MacKay, N. Ames, J. Curran, D.R. Bouchard, P.J. Jones. University of Manitoba, Canada, Richardson Centre for Functional Foods and Nutraceuticals, Canada, Agriculture Canada, Canada, Pulse Canada, Canada and University of New Brunswick, Canada. C284 966.37 The Effect of a High Fat Meal Containing a Culinary Dose of Spices on Postprandial Endothelial Function. K.S. Petersen, S.G. West, H.L. VanEvery, E.S. Oh, C.J. Rogers, P.M. Kris-Etherton. Pennsylvania State University. C285 966.38 Effects of Almond and Cocoa/Dark Chocolate Consumption, Alone and in Combination, on 24-hr Ambulatory Blood Pressure in Normotensive Overweight and Obese Individuals. C.E. Berryman, Y. Lee, S.G. West, K.G. Lapsley, A.G. Preston, J.A. Fleming, P.M. Kris-Etherton. Penn State University, The Almond Board of California and The Hershey Company. C286 966.39 Dietary Advanced Glycation End Products and Lipid Profile in Diabetes Mellitus Subjects with or Without Complications. C. Luevano-Contreras, K. ChapmanNovakofsky. University of Guanajuato, Mexico and University of Illinois.
967. NUTRITION AND MUSCULOSKELETAL HEALTH Poster (Sponsored by: Nutrition and Chronic Disease RIS) Tue. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C287 I 967.1 A Diet Containing Soy Protein Isolate Is Not Detrimental to Skeletal Development in Spontaneously Hyperphagic, Adolescent Male OLETF Rats. R.K. Dirkes, M.W. Richard, G.M. Meers, D.N. Butteiger, E.S. Krul, J.P. Thyfault, R.S. Rector, P.S. Hinton. University of Missouri—Columbia, Research Service—Harry S Truman Memorial VA Hospital, DuPont Nutrition and Health, University of Kansas Medical Center and Kansas City VA Medical Center. C288 II 967.2 Effects of Shiikuwasha Extract Supplementation on Muscle Protein Degradation in the Rat Model of Insulin Resistance. T. Okamoto, Y. Sakata, K. Oshio, H. Nakamura, H. Iwamoto, K. Namba, K. Narita, N. Maeda, F. Yoshizawa, Y. Takeda. Morinaga Milk Industury Co., Ltd., Japan, Faculty of Agriculture and Utsunomiya University, Japan. C289 I 967.3 Effects of Shiikuwasha Extract Supplementation on Muscle Protein Synthesis in the Rat Model of Insulin Resistance. K. Narita, N. Maeda, T. Okamoto, Y. Sakata, K. Oshio, H. Nakamura, H. Iwamoto, K. Namba, Y. Takeda, F. Yoshizawa. Faculty of Agriculture, Utsunomiya University, Japan, Morinaga Milk Industry Co. Ltd., Japan. C290 II 967.4 Vitamin K, Vitamin D, and Lower Extremity Function: Results from the Osteoarthritis Initiative and Health, Aging and Body Composition Studies. K. Shea, R.F. Loeser, S.B. Kritchevsky, D.K. Houston, T.E. McAlindon, S.L. Booth. Tufts University, University of North Carolina, Wake Forest Medical Center and Tuft Medical Center. C291 I 967.5 Effects of Protein-Based Supplementation and Endurance Training on Muscle Mass and Mitochondrial Enzyme Activity in Rats Treated with Hindlimb Suspension. C. Chen, P. Chen, C. Wu, Y. Yang, C. Chen, Y. Liao. National Taipei University of Nursing and Health Sciences, Taiwan and University of Taipei, Taiwan. C292 II 967.6 The Association Among Vitamin D Status, Bone Geometry and Muscle Structure in 14 to 18 y Female Adolescents with Usual Intake of
