april 22-26

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Apr 22, 2017 - Medicine, Drexel University College of Medicine and University of Michigan. 11:30 .... Sanford Burnham Prebys Medical Discovery Institute.

American Society for Investigative Pathology

American Society for Nutrition

American Society for Pharmacology and Experimental Therapeutics

TRANSFORMING THE FUTURE THROUGH SCIENCE

CHICAGO

APRIL 22-26 PROGRAM

2017

EXPERIMENTAL BIOLOGY 2017 Transforming the Future through Science McCormick Place Convention Center April 22–26, 2017 AN ANNUAL MEETING OF PROFESSIONAL RESEARCH SCIENTISTS HOST SOCIETIES

American Association of Anatomists (AAA) The American Physiological Society (APS) American Society for Biochemistry and Molecular Biology (ASBMB) American Society for Investigative Pathology (ASIP) American Society for Nutrition (ASN) American Society for Pharmacology and Experimental Therapeutics (ASPET)

GUEST SOCIETIES American College of Pediatrics (ACP) American Society of Animal Science (ASAS) Chinese Society for Anatomical Sciences (CSAS) Association of Nutrition Departments and Programs (ANDP) Society for Vertebrate Paleontology (SVP) Brazilian Society for Food and Nutrition (BSFN) Canadian Nutrition Society (CNS-SCN) APS Chinese Nutrition Society (CNS) American College of Sports Medicine (ACSM) Collegiate and Professional Sports Dietitians American Federation for Medical Research (AFMR) Association (CPSDA) Brazilian Society of Physiology (SBFiS) Friedman Fellows Biomedical Engineering Society (BMES) ILSI North America (ILSI) Microcirculatory Society (MCS) Institute of Food Technologists (IFT) The Physiological Society (PhySoc) International Colleges for the Advancement of Nutrology (ICAN) International Society for Research in Human ASBMB Milk and Lactation (ISRHML) Biochemical Society Japan Society of Nutrition and Food Science (JSNFS) Division of Biological Chemistry–American Chemical Society (ACS) Korean Nutrition Society (KNS) Panamerican Association for Biochemistry and Molecular National Board of Physician Nutrition Specialists (NBPNS) Biology (PABMB) North American Society for Pediatric Gastroenterology, RNA Society (RNA) Hepatology and Nutrition (NASPGHAN) Society for Experimental Biology and Medicine (SEBM) Nutrition Society of Taiwan (NST) Plant Phenolics and Human Health Research Interest Group ASIP (PhenHRIG) American Society for Matrix Biology (ASMB) Society for Nutrition Education and Behavior (SNEB) American College of Veterinary Pathologists (ACVP) Society for Pediatric Research (SPR) Association of Pathology Chairs (APC) Southern Society for Clinical Investigation (SSCI) American Physician Scientists Association (APSA) The Nutrition Society UK (NSUK) The Histochemical Society (HCS) Vitamin Society of Japan (VJS) The Society for Cardiovascular Pathology (SCVP) Società Italiana di Patologia e Medicina Traslazionale/Italian ASPET Society of Pathology and Translational Medicine (SIPMeT) Behavioral Pharmacology Society (BPS) Society of Toxicologic Pathology (STP) Global GI Club (GGC) Japanese Pharmacological Society (JPS) ASN

AAA

Academy of Nutrition and Dietetics (AND) African Graduate Nutrition Students Network (AGSNET) American Academy of Pediatrics (AAP)

Experimental Biology Management Office 9650 Rockville Pike, Bethesda, MD 20814 Phone: 301-634-7010; Fax: 301-634-7014; Email: [email protected] Web: www.experimentalbiology.org Copyright © 2010 by the Federation of American Societies for Experimental Biology

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TABLE OF CONTENTS 2017 Host and Guest Societies............................................i Host Society Officers......................................................... iii 2017 EB Committees......................................................... iv Office * Locations * Hours * Telephone Numbers...........v Code of Conduct................................................................ vi General Information........................................................ vii Registration........................................................................ vii Society Ticketed Events.................................................... viii Attire/Dress Code................................................................ ix Badge Pick-Up.................................................................... ix Certificate of Attendance..................................................... ix Coat Check/Luggage Storage............................................. ix Conference Photo Consent.................................................. ix Drinking Policy................................................................... ix EB17 App............................................................................ ix EB2018—San Diego........................................................... ix E-Posters and Poster Pick-Up............................................. ix Online Poster Access.............................................................x Exhibits.................................................................................x Product Workshops and Exhibitor Showcases......................x Family Room and Nursing Lounge.......................................x First Aid................................................................................x Food And Beverage...............................................................x Housing Inquiries..................................................................x Internet Access......................................................................x Wireless Access.....................................................................x Lost and Found.....................................................................x Message Center/Literature Tables.........................................x Poster Presentations And Policy...........................................x Recording............................................................................ xi Restaurant Reservations And City Information.................. xi Speaker Information and Speaker Preview Rooms............ xi Special Needs..................................................................... xii Transportation.................................................................... xii Ground Transportation....................................................... xii Young Experimental Scientists (Y.E.S.) Mixer.................. xii

Diagrams McCormick Place Convention Center.............................. xiii Hyatt Regency McCormick Place.................................... xvii Hilton Chicago.................................................................. xix EB-Sponsored Special Programs NIH Grant Seminar Workshop Series..................... xxii NIH Career Development (K) Awards...................xxii NIH Fellowship (F) Awards............................................. xxii Career Development Seminars & Workshops................ xxiii Oral Sessions by Day/Society Friday, April 21.....................................................................1 Saturday, April 22.................................................................3 Sunday, April 23..................................................................37 Monday, April 24................................................................82 Tuesday, April 25..............................................................120 Wednesday, April 26.........................................................169 Poster Sessions by Day/Society Sunday, April 23................................................................185 Monday, April 24..............................................................282 Tuesday, April 25..............................................................381 Wednesday, April 26.........................................................477 Exhibits General Information..........................................................493 Floor Plan..........................................................................494 Company Index.................................................................496 Government Exhibits........................................................529 Product Index....................................................................530 Books, Journals, Publications........................................533 Exhibitor Workshops......................................................551 Exhibitor Showcases.......................................................552 Indexes Author/Speaker Index.......................................................553

HOST SOCIETY OFFICERS

K. Topp, President P. Brauer, President-Elect L. Opperman, President Emeritus V. DeLeon, Secretary-Treasurer P. Trainor, Program Co-chair M. Dunnwald, Program Co-chair S. Boynes, Executive Director

J. Reckelhoff, President P. Molina, Past President D. Brown, President-Elect M. Frank, Executive Director R. Hester, Joint Program Committee Chair

N. Ahn, President and Program Co-Chair S. McKnight, Past President and Program Co-Chair T. M. Antalis, Treasurer J. DuBois, Secretary B. A. Gordon, Executive Director

G.K. Michalopoulos, President W.B. Coleman, Past President D.G. Remick, President-Elect A. Nusrat, Vice President S.P. Monga, Secretary-Treasurer R.N. Mitchell, Program Committee Chair M. E. Sobel, Executive Officer

M. L. Neuhouser, President M. A. Johnson, Vice President C. J. Field, Vice-President Elect P. M. Coates, Treasurer S. Percival, Secretary R. M. Russell, Foundation Chair J. E. Courtney, Executive Officer S. K. Fried, Program Chair

D.R. Sibley, President J.D. Schuetz, President-Elect K.E. Thummel, Past President C.P. France, Secretary/Treasurer J.A. Siuciak, Executive Officer S.A. Waldman, Program Committee Chair

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2017 EB COMMITTEES

EXPERIMENTAL BIOLOGY BOARD R. Hester, APS, Chair M. Dunnwald, AAA M. B. Furie, ASIP J. Hill, ASN P. F. Hollenberg, ASPET L. Justement, AAI D. Raben, ASBMB

MANAGEMENT COMMITTEE J. Courtney, ASN, Chair S. Boynes, AAA M. Frank, APS B. Gordon, ASBMB J. Siuciak, ASPET M. E. Sobel, ASIP

EXHIBITS ADVISORY COMMITTEE J. Zacka, Chair, Worthington Biochemical Corp B. Archibald, Pro Scientific, Inc. J. Kearney, Exhibits Manager, FASEB OSMC C. Locke, Drummond Scientific O. Padilla, Bio-Rad Laboratories H. Santos, Scientific Industries, Inc. A. Waluszko, UVP/Analytik Jena

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OFFICE * LOCATIONS * HOURS * TELEPHONE NUMBERS AAA McCormick Place, Room W176C Saturday–Tuesday, 7:30 AM–5:30 PM APS ....................................................................... 312-528-8204 Hyatt Regency McCormick Place, Jackson Park A Saturday–Tuesday, 7:00 AM–5:00 PM Wednesday, 7:00 AM–3:00 PM ASBMB ............................................................... 312-949-8601 McCormick Place, Room W185D Sunday- Tuesday, 9:00 AM–4:30 PM Wednesday, 9:00 AM- 12:00 PM ASIP...................................................................... 312-949-8615 McCormick Place, Room W181C Saturday–Tuesday, 8:00 AM–5:00 PM ASN....................................................................... 312-791-6600 McCormick Place, Room S101B Saturday–Tuesday, 7:30 AM–5:30 PM ASPET.................................................................. 312-949-8600 McCormick Place, Room W471B Saturday, 11:00 PM–4:00 PM, Sunday, 7:30 AM–6:00 PM Monday–Tuesday, 7:30 AM–6:30 PM Wednesday, 7:30 AM–4:00 PM

INFORMATION DESK ..................................... 312-528-6778 Hyatt Regency McCormick Place, Boardroom 5 Meeting Management Office Saturday–Wednesday, 8:00 AM–5:00 PM INFORMATION DESK ..................................... 312-294-6621 Hilton Chicago, Room PDR6 Saturday–Wednesday, 8:00 AM–5:00 PM LOST AND FOUND ........................................... 312-949-8604 McCormick Place, Hall F, Registration B Meeting Management Office MEETING MANAGEMENT OFFICE ............ 312-949-8604 McCormick Place, Hall F, Registration B Thursday, 7:30 AM–5:00 PM Friday–Saturday, 7:30 AM–6:00 PM Sunday–Wednesday, 7:30 AM–5:00 PM REGISTRATION .............................................. 312-791-7104 McCormick Place, Hall F, Registration B Friday, 1:00 PM–6:00 PM, Saturday, 7:00 AM–8:00 PM Sunday–Tuesday, 7:00 AM–5:00 PM Wednesday, 7:00 AM–3:00 PM SPECIAL NEEDS/ADA...................................... 888-441-7575 McCormick Place, Hall F, Registration B

AV HEADQUARTER OFFICE ........................ 312-949-8616 McCormick Place, Room 195 Friday–Wednesday, 7:00 AM–6:00 PM

SPEAKER PRACTICE ROOM McCormick Place, Room W182........................... 312-949-8620 Saturday–Wednesday, 7:00 AM–6:00 PM

CAREER RESOURCES Registration Lobby Saturday, 9:00 AM– 5:00 PM

McCormick Place, Room W191........................... 312-949-8621 Saturday–Wednesday, 7:00 AM–6:00 PM

McCormick Place, Hall F2 Sunday–Monday, 9:00 AM–5:00 PM, Tuesday, 9:00 AM–4:00 PM McCormick Place, Skyline Ballroom Wednesday, 9:00 AM–12:00 PM EXHIBIT MANAGEMENT .............................. 312-949-8609 McCormick Place, Hall F Thursday–Tuesday, 8:00 AM–5:00 PM EXHIBITOR REGISTRATION ....................... 312-949-8611 McCormick Place, Hall F, Registration C Friday–Tuesday, 8:00 AM–4:00 PM FIRST AID ........................................................... 312-791-6060 McCormick Place, Transportation Gates 43 and 44, Level 1 Friday–Wednesday, 7:30 AM–6:00 PM

McCormick Place, Room S101A ......................... 312-949-8622 Saturday-Wednesday, 7:00 AM–6:00 PM MCCORMICK PLACE 2301 S. King Drive Chicago, IL 60616 Main #: 312-791-7000 HYATT REGENCY MCCORMICK PLACE 2233 S. Dr. Martin Luther King Jr. Dr. Chicago, IL 60616 Main #: 312-567-1234 HILTON CHICAGO 720 South Michigan Avenue Chicago, IL 60605 Main #: 312-922-4400

EB INFO/HOUSING DESK .............................. 312-949-8612 McCormick Place, Hall F, Registration B Friday, 1:00 PM–6:00 PM, Saturday, 7:00 AM–6:00 PM Sunday 7:00 AM–5:00 PM

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CODE OF CONDUCT Experimental Biology is committed to providing a friendly, safe, and welcoming environment for all, regardless of gender, sexual orientation, disability, race, ethnicity, religion, national origin, or other protected characteristics. We expect all attendees, media, speakers, volunteers, organizers, venue staff, guests, and exhibitors to help us ensure a safe and positive conference experience for everyone.

♦♦Sustained disruption of scientific sessions or other events ♦♦Unwelcome and uninvited attention or contact ♦♦Physical assault (including unwelcome touch or groping) ♦♦Real or implied threat of physical harm

We expect all participants at EB2017 to abide by this ♦♦Real or implied threat of professional or financial damage or harm Code of Conduct in all venues, including ancillary events and all social gatherings. What To Do If You Witness or Experience Conduct ♦♦Exercise consideration and respect in your speech That Violates the Code: and actions. EB and participating Society staff will be happy to help ♦♦Refrain from demeaning, discriminatory, or participants contact convention center/hotel/venue security or local law enforcement, and otherwise assist harassing behavior and speech. those experiencing harassment, to enable them to feel ♦♦Be mindful of your surroundings and of your fellow safe for the duration of the conference. We value your participants. Alert the EB Management Office if you attendance, and want to make your experience as notice a dangerous situation, someone in distress, or productive and professionally stimulating as possible. violations of this Code of Conduct. Please contact the EB Management Office or Unacceptable Behaviors the nearest participating Society office or email [email protected] to file a Unacceptable Behaviors Include: complaint. All reports will be confidential. ♦♦Intimidating, harassing, abusive, discriminatory, derogatory or demeaning speech or actions by any Consequences of Unacceptable Behavior participant at EB2017 and at all related events Unacceptable behavior from any participant at ♦♦Harmful or prejudicial verbal or written comments or visual images related to gender, sexual orientation, race, religion, disability, or other personal characteristics

EB2017, including attendees, sponsors , exhibitors, contractors, volunteer leaders, vendors, venue staff, and anyone with decision-making authority, will not be tolerated. Anyone asked to stop unacceptable behavior is expected to comply immediately.

♦♦Inappropriate use of nudity and/or sexual images in If a participant engages in unacceptable behavior, public spaces (including presentation slides) Experimental Biology staff may take any action they ♦♦Deliberate intimidation, stalking, or following deem appropriate, including removal from EB2017, without refund, and/or future EB meetings. Egregious ♦♦Harassing photography violations will result in more severe sanctions, ♦♦Photographing slides of oral presentations and including the possibility of reporting to local law posters without the express permission of the enforcement. presenter/author See the Scientific Integrity Policy for more information. ♦♦Recording of scientific and other sessions without the express permission of the participants

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GENERAL INFORMATION REGISTRATION McCormick Place, Hall F, Registration B Hours Friday: 1:00 pm–6:00 pm Saturday: 7:00 am–8:00 pm Sunday–Tuesday: 7:00 am–5:00 pm Wednesday: 7:00 am–3:00 pm Fees Host/Guest Society Member $560 Nonmember $750 Retired Society Member $160 Retired Nonmember $190 *Graduate Student Member $95 *Graduate Student Nonmember $120 **Undergraduate Member/Nonmember $30 ***Postdoctoral Trainee Member $435 ***Postdoctoral Trainee Nonmember $435 1-Day Member $205 1-Day Nonmember $350 ****High School Teachers and High School Students Free

****High School Teachers and High School Students: You must be a certified High School Teacher currently teaching High School students. You do not qualify for this category if you are currently teaching at a University or a Hospital. Credentials or a letter from the school principal will need to be provided on-site to receive your badge. High School Students should bring a student ID card or a letter signed by your teacher to receive your badge. Guest Registration: Spouses and other non-scientist family members who wish to see a family member’s presentation may pick up a guest pass at a participating Society office or the Meeting Management Office. Guest passes allow admittance to a family member’s session but does not include other exhibits, scientific sessions, or social activities.

Cancellation and Refund Policy: The registration receipt and a letter requesting a refund of the registration fee must be received by March 23, 2017. A $50 non-refundable processing fee will be deducted and after March 23, 2017 no refunds *Graduate Student Registration: You must have will be issued. Please mail to: Experimental Biology a department head or research advisor certify your Registration Office 9650 Rockville Pike Bethesda, student eligibility. If registering online, enter the MD 20814-3998 name and email address of your department head. If registering at the meeting, bring your ID card or Exhibitor Registration: a letter signed by your department head. “Student” Company representatives and guests of exhibitors may will be indicated on your badge. Postdoctoral fellows, register at the Exhibitor Registration Desk in Hall F, hospital residents, interns and laboratory technicians Registration B and C on the 2nd level at the McCormick do not qualify as students. Place. Registration will be open Friday–Tuesday. **Undergraduate Students and High School Students: Registration will be accepted in advance. To receive your badge on-site, bring a student ID card or a letter signed by your department head, research advisor or teacher. ***Postdoctoral Trainee: Trainees have obtained their doctoral degree within the last five years and are currently enrolled in a postdoctoral trainee program.

New in 2017! EB Welcome Reception Saturday, April 22, 7:00 pm–8:30 pm Join fellow attendees for our first-ever, interdisciplinary meet and mingle. Appreciate the power and energy of the EB Meeting as all career levels come together for fun and networking. Light refreshments will be served. Member-attendees receive one complimentary drink ticket when they sign up for the event during EB Meeting registration. Cash bar also available.

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SOCIETY TICKETED EVENTS The following special Society activities have been planned and may require a fee in addition to the Experimental Biology 2017 registration fee.

XVIIth Annual ASIP/AAA Career Development and Mentoring Program and Lunch: Developing Your Core Message: An Interactive Session on Crafting an Effective Elevator Speech Sunday, April 23, 2017 at 11:45 am AAA TICKETED EVENT: *ASIP Trainee members and AAA Student Members AAA Closing Awards Ceremony & Reception— will receive a complimentary ticket* Tuesday, April 25 $15 for ASIP/AAA Members Join the American Association of Anatomists at the $30 for Non-Members Closing Awards Ceremony on Tuesday, April 25, 2017. The Awards Ceremony is from 7:00 pm to 10:00 pm at Scientific Interest Group Networking Sessions the Hilton Chicago and will feature a cocktail reception, and Poster Discussions dinner, & presentation of AAA awards. Tickets are Tuesday, April 25, 2017 at 5:30 pm FREE FOR ALL ATTENDEES $85 on-site. APS TICKETED EVENT: APS Closing Party—Wednesday, April 26, 2017 7:00 pm to 10:00 pm in the Hyatt Regency McCormick Place. Tickets are $30 in advance and $40 onsite. The closing party will include live bands GI Distress and the winner of the battle of the band. ADMISSION IS BY TICKET ONLY.

Please sign up for these events when registering for Experimental Biology by checking the boxes on the registration form.

ASN TICKETED EVENTS: ASN on Demand Purchase access to the ASN at Experimental Biology 2017 sessions via ASN on Demand. Slide-synced Please sign up for this event when registering audio or podcasts can be accessed at your convenience for the meeting by checking the boxes on the on your computer or mobile device 24/7. Sessions registration form. offered are subject to permission by the presenter. Advance Purchase: $100 • Post-Meeting: $350 ASBMB TICKETED EVENT: ASBMB Presents a Day of Development for ASN Emerging Leaders Poster Competition Graduate Students and Postdoctoral Fellows Saturday, April 22 at 5:00 pm–7:00 pm McCormick Place Hall F Saturday, April 22nd, 8:30 am–4:30 pm Details at www.asbmb.org/meeting2017 Poster viewing is free of charge. Advance registration Sign up during EB meeting registration (limited space). is advised. $25, ASBMB Members, $35, all other EB registrants ASN Presidential Symposium Events include career panel, workshops, speakers Sunday, April 23 at 8:30 am–10:00 am luncheon and networking. McCormick Place Ballroom S100BC Chair: Marian L. Neuhouser, PhD, President, ASIP TICKETED EVENTS: American Society for Nutrition. Session is free of XVIIth Annual Workshop on Graduate charge. Advance registration is advised. Education in Pathology: PhD Workforce Saturday, April 22, 2017 at 11:45 am ASN Awards Ceremony $15 for ASIP Members Sunday, April 23 at 6:00 pm–7:30 pm $30 for Non-Members McCormick Place Ballroom S100BC Ceremony is free of charge. Advance registration Committee for Career Development & Diversity is advised. Workshop and Breakfast: Developing Your Personal Brand for Career Success Sunday, April 23, 2017, at 7:00 am $10 for ASIP Members $20 for Non-Members

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Fellows, 50-Year Members, and Past Presidents Luncheon Monday, April 24 at 11:30 am–2:00 pm Hilton Chicago Join ASN in celebrating the accomplishments and achievements of our past and present Fellows, 50Year members, and former society presidents over lunch at the annual meeting. This luncheon will include a presentation honoring the newly inducted class of 2017 ASN Fellows. All members are invited to attend; guests are permitted. *All newly inducted Fellows will receive two complimentary tickets. $25 for ASN Members • $50 for Non-Members

COAT CHECK/LUGGAGE STORAGE McCormick Place, Level 1 Gate 44 Luggage storage and coat check will be available Friday through Wednesday. It costs $3 per coat checked and $4 per bag checked. Please do not bring luggage to the meeting rooms. CONFERENCE PHOTO CONSENT Upon registering for Experimental Biology 2017, you affirmed that you agreed to allow official Experimental Biology photographers to record your participation and reproduce your likeness in publications, online, etc.

DRINKING POLICY Alcoholic beverages will be offered at various social ASN Sunrise Boot Camp activities and the Experimental Biology participating Sunday, Monday & Tuesday Mornings Societies, the McCormick Place, the Hyatt Regency 6:30 am–7:30 am McCormick Place, and the Hilton Chicago, encourage Grant Park, Across from Hilton Chicago Join your fellow EB attendees for an early morning responsible drinking. Alcohol will only be served to those over the age of 21 and some participants may workout with ASN. You’ll feel better all day! be required to provide photo identification. Alcoholic Please sign up for these activities when registering for beverages are allowed only in specific areas and must Experimental Biology by checking the boxes on the not be taken out of those immediate areas. registration screen. EB17 APP ATTIRE/DRESS CODE Download the mobile app today to easily search for Attire is business casual. Wear comfortable shoes and sessions, speakers, exhibitors, and connect with your dress in layers. colleagues—all in the palm of your hand. Search for Experimental Biology 2017 in the App store BADGE PICK-UP or navigate to http://m.core-apps.com/eb2017 on Badges were not mailed in advance. There will your device. be on-site kiosks to print badges at the McCormick Place, Hall F Registration B and C on the 2nd level. EB2018—SAN DIEGO Lost or forgotten badges can only be replaced at EB18 will be held in San Diego, CA April 21–25, 2018. the Replacement Badge Counter at the cost of $25. Start planning NOW for your participation at EB18! Program information will ONLY be available online prior to the meeting for individual downloading. You E-POSTERS AND POSTER PICK-UP should also plan to download the meeting app prior McCormick Place, Hall F Mira has arranged for pre-ordering of poster printing to arriving. and delivery to the Experimental Biology 2017 NOTE: Badges must be worn at all times and no meeting. Information was sent in advance with access will be granted to the Exhibit Hall or scientific confirmation information. Posters may be picked up sessions without a badge. Children under the age during registration hours (Friday, 1:00 pm–6:00 pm, of 16 are not required to wear a badge but must be Saturday, 7:00 am–6:00 pm, Sunday–Wednesday, 7:00 am–5:00 pm). Onsite printing will be available accompanied by a registered attendee. using FedEx Kinkos on Level 2 in the West Building. CERTIFICATE OF ATTENDANCE Visit FedEx online to order, or contact FedEx at the Beginning on Monday, April 24, Certificate McCormick Place by calling (312) 949-2100. of attendance can be printed at a kiosk located at the Registration Desk in the McCormick Place, Hall F, Registration B and C.

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ONLINE POSTER ACCESS Following the EB 2017 meeting, all registered attendees will have access to PDFs of the online posters through the e-poster link on the EB 2017 website. All presenters are requested to upload a PDF file of their poster starting on February 21. Only registered attendees will be able to access the e-poster site.

FOOD AND BEVERAGE Concessions will be open in the West Food Court, Saturday–Wednesday. Food service offers continental breakfast, hot foods, sandwiches, salads, light snacks and beverages. A number of concessions throughout the exhibit halls will be open offering a variety of “grab and go” foods.

EXHIBITS McCormick Place, Hall F Exhibits will be open from 9:00 am–4:00 pm, Sunday– Tuesday. See pages 496–550 for complete list of exhibiting companies and products and visit the EB17 app to customize your visit and itinerary. Visit www.experimentalbiology.org and click on Floor plan and Current Exhibitors to organize your booth visits. Admission to the Exhibits is by official badge only. Children under the age of 16 are permitted access to the Exhibit Hall without a badge during show hours but must be accompanied by a registered adult. Children are not permitted in exhibit halls during set up or dismantling hours.

HOUSING INQUIRIES McCormick Place, Hall F, Registration B An Experient housing bureau representative will be located in Hall F, at the Information Kiosk to manage hotel questions and concerns.

PRODUCT WORKSHOPS AND EXHIBITOR SHOWCASES Exhibitor workshops and showcases provide exhibiting companies with opportunities to talk about new product lines and services and offers audience interaction and informal discussion beyond the exhibit hall. Product workshop and showcase descriptions, times and locations are listed on pages 551–552.

LOST AND FOUND Please visit the Meeting Management Office located in Hall F, of the McCormick Place to look for items lost or turned in items found.

FAMILY ROOM AND NURSING LOUNGE McCormick Place, Hall F (See EB Management Office) The family room will be open during registration hours. The area is intended to provide a quiet environment where children can be taken for a break.

INTERNET ACCESS Cyber Café McCormick Place, Hall F, Registration B Internet kiosks will be provided for checking email. WIRELESS ACCESS Complimentary wireless access will be available Friday through Wednesday at both the McCormick Place and the Hyatt Regency McCormick Place.

MESSAGE CENTER/LITERATURE TABLES McCormick Place, Hall F, Registration B The message center and free literature tables will be located in Hall F. Registrants can check for messages and post fliers advertising social events or upcoming meetings. Exhibitors are not permitted to display any materials on the literature tables.

POSTER PRESENTATIONS AND POLICY McCormick Place, Hall F All poster presentations are scheduled in Hall F FIRST AID and the Skyline Ballroom at McCormick place. McCormick Place, Transportation Gates 43 and Late-breaking posters are scheduled in the Skyline 44 on Level 1 Ballroom (Wednesday only). Presenters must hang A First Aid room will be located on the Mezzanine their posters on the appropriate poster board no later Level the McCormick Place conference center. A than 9:00 am on the day of presentation. Presentation nurse/First aid administrator will be on duty during times for each author are listed at the beginning of key hours. the session. Your poster board number is the alpha/ numerical listing next to your abstract number.

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Sunday–Tuesday Wednesday

Location

Poster Set-up

Poster Viewing

Poster Presentation

Poster Tear-down

Hall F

7:00 am 9:00 am

9:00 am–4:00 pm

Times vary; see individual Society

4:00 pm–6:00 pm

Skyline Ballroom

7:00 am 9:00 am

9:00 am–4:00 pm

Times vary; see individual Society

4:00 pm–6:00 pm

Presenters are to stand at their poster board during the assigned time. Do not leave belongings, poster containers or any materials under the poster boards or in the poster area. EB Management is not responsible for articles left in the poster area. Pushpins are available at the Poster Attendant stations.

RESTAURANT RESERVATIONS AND CITY INFORMATION McCormick Place, West Level 3 Center Lobby Participants may obtain information about local restaurants and things to do in Chicago at the Concierge Desk located at the West Level 3 Center Lobby.

SPEAKER INFORMATION AND SPEAKER PREVIEW ROOMS McCormick Place, W182, W191, S101A Speakers are not required to bring a laptop! All Presenters must be at their poster boards during session rooms will be equipped with a data projector assigned session presentation times, as designated by and computer. Bring presentations on a Windowseach society. readable USB flash drive or CD. Back-up presentation Posters must remain on display all day from formats are recommended. Please visit our website under general information for instructions on preparing 9:00 am–4:00 pm. your presentation www.experimentalbiology.org. Posters that do not remain on display all day during their assigned day may, at the discretion of the Speakers should visit the Speaker Preview Room to review and check presentation compatibility at programming society, be ineligible for awards. least 4 hours prior to their session. Speakers must Recording (photographing, audio taping or videotaping) arrive half an hour prior to scheduled start time any presentation/session is PROHIBITED, except by to allow technicians time to load the presentation an EB-authorized agent or by first authors who want onto the computer. Additional audio visual to photograph their poster presentation. equipment must be requested in advance via email at [email protected] or by contacting the Society that programmed your Program Printed programs WILL NOT be distributed. Program abstract or invited you to give a talk. information as well as the app will be available for The Speaker Preview Rooms will be open during the online downloading prior to the meeting. following times: RECORDING Room W182, Phone: 312-949-8620 Photographing, audio taping, videotaping any Saturday–Wednesday, 7:00 am–6:00 pm presentation (oral or poster) or exhibit display is Room W191, Phone: 312-949-8621 prohibited, except by an Experimental Biology Saturday–Wednesday, 7:00 am–6:00 pm authorized agent for official purposes, or by first Room S101A, Phone: 312-949-8622 authors who want to photograph their own poster Saturday–Wednesday, 7:00 am–6:00 pm presentation. Any policy violations will result in being asked to leave. Poster Presentation Policy: Presenters must hang their posters no later than 9:00 am on their day of presentation.

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SPECIAL NEEDS Registrants with special needs should contact the EB Meeting Management Office in advance at [email protected]perimentalbiology.org. For onsite inquiries, please contact the Meeting Management Office in Hall F, Registration B of the McCormick Place. For specific information on the McCormick Place’s accessibility, contact the Guest Services Department at 312-791-7104. The McCormick Place staffs the Information Desk in the West Level 3 Center Lobby of the McCormick Place and is able to provide accessibility information for local area attractions. For information on Chicago area attractions, visit our EB2017/Chicago Microsite for more information www.choosechicago.com/ExperimentalBiology2017.

Taxi Service Taxis are plentiful and easy-to-hail in downtown, and offer a convenient way to get around the city. Taxis charge a base rate of $2.25 for the first 1/9 mile, plus, $.20 for each additional 1/9 mile. If a gas surcharge is in effect, a sign will be displayed inside the taxicab and a surcharge may apply. Tolls are an extra charge; taxis charge $1 for the first additional passenger over age 12 and under age 65. Each additional passenger after first passenger, over 12 and under 65 is $.50. It is standard to tip the driver about 15–20 percent of the fare, plus $1–2 per bag if the driver helps you with luggage.

TRANSPORTATION O’Hare International Airport, located 13 miles from downtown, is one of the largest airports in the world. For visitors needing information or directions, airport information booths are located on the lower levels of the domestic terminals and on the upper and lower levels of the International Terminal.

METRA Commuter Rail The high-speed Metra train connects outlying suburbs to downtown and is an easy way to get into the heart of the city fast. For fares and maps, visit METRA’s website at metrarail.com.

Please note that all fares are subject to change.

YOUNG EXPERIMENTAL SCIENTISTS (Y.E.S.) MIXER Midway International Airport is located 10 Hilton Chicago, Continental Ballroom miles from downtown Chicago and offers another The Y.E.S. Mixer is open to all EB registrants and is scheduled Monday, April 24, 8:00 pm–11:30 pm. You convenient travel option for visitors. must wear your badge to gain admittance. Dance, relax, and network while enjoying complimentary GROUND TRANSPORTATION Both airports offer plentiful taxi service to downtown snacks and soft drinks. EB host societies encourage and the suburbs. Rates range from $40–$50 from responsible drinking and will only serve alcohol to O’Hare, and $30–$40 from Midway. Rates vary based those above the age of 21 with proper identification. on travel time and are subject to change. Hotel Shuttle Service: Complimentary bus service is available between the McCormick Place and the contracted EB hotel community. Please reference below for specific pickup locations/routes. A transportation agent will be available at each designated hotel, during the morning hours. The shuttle bus drivers will not make additional stops. The shuttle bus drop-off and pick-up location at the McCormick Place is at Transportation Gates 43 and 44 on Level 1. If you need special assistance, such as a wheelchair lift, please contact the Transportation Services desk at: 1-888-441-7575. Buses run on average every 10–15 minutes.

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Experimental Biology exhibitors offer the best tools and resources available in research today! Join the exhibitors at 10:00 am for coffee and 2:00 pm for snacks and learn the latest and greatest from more than 300 companies.

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Hilton Chicago Lobby Level 720 South Michigan Avenue Chicago, IL 60605 Phone: 312-922-4400

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Hilton Chicago Second Floor 720 South Michigan Avenue Chicago, IL 60605 Phone: 312-922-4400

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EB-SPONSORED SPECIAL PROGRAMS NIH GRANT SEMINAR WORKSHOP SERIES Convention Center, Career Center Area, Hall F2

equivalent). Among the K awards discussed will be the K01 Mentored Research Scientist Development Award, the K02 Independent Scientist Award, the K22 Career Transition Award, the K08 Mentored Clinical Scientist Development Award, the K23 Mentored Patient Oriented Career Development Award, the K24 Mid-Career patient Oriented Career Award, and K25 Mentored Quantitative Scientist Career Development Award. The interactive discussion will give attendees an opportunity to ask questions of and obtain insight from an NIH representative on these and other awards available for beginning investigators.

The FASEB Office of MARC and Professional Development Programs in association with the Experimental Biology 2017 (EB2017) Management Committee will sponsor career development seminars and a NIH Grant Seminar Workshop in the EB2017 Career Center located in Hall F2 of the McCormick Convention Center. There is no fee or pre-registration associated with the workshops and seminars; however, EB2017 meeting registration NIH FELLOWSHIP (F) AWARDS is required to participate in all seminars/ sessions. Handouts and resource materials will be provided onsite. Advance seating reservations are 1:00 pm–2:30 pm, Monday/Tuesday, Career Center, Hall F2 not required. This presentation will focus on the NIH’s Ruth Critiquing of CV/resumes and the career coaching/ L. Kirschstein National Research Service Awards counseling sessions will be by appointment only (NRSA). The NRSA research training fellowship (F) and the times are as follows: Saturday, April 22, awards are targeted to individuals with or seeking in the registration area, Sunday, April 23–Monday, research doctoral degrees (Ph.D. and equivalent) April 24, 9:00 am–5:00 pm and Tuesday, April 25, and clinical doctoral degrees (M.D. and equivalent). 9:00 am–4:00 pm in the FASEB Career Center. Among the F awards discussed will be the F30, Wednesday, April 26, 9:00 am–12:00 pm will take NRSA Individual Predoctoral MD/PhD or Other place in the Skyline Ball Room West 375A. Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual Predoctoral Fellowship, the F31 NRSA Individual Predoctoral Fellowship to Promote NIH CAREER DEVELOPMENT Diversity in Health-Related Research Award, the F32 (K) AWARDS NRSA Individual Postdoctoral Fellowship Award, and the NRSA Individual Senior Fellowship Award. 9:00 am–10:30 am, Monday/Tuesday, The interactive discussion will give attendees an Career Center, Hall F2 opportunity to ask questions of and obtain insight This presentation will focus on the NIH’s Career from an NIH representative on these and other awards Development Awards (K) including the most recent available for pre- and postdoctoral fellows and K99/00 Pathways to Independence Award (for senior investigators. postdoctoral scientists) and other K awards targeted to individuals with research doctoral degrees (Ph.D. and equivalent) and clinical doctoral degrees (M.D. and

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CAREER DEVELOPMENT SEMINARS & WORKSHOPS

Career/Planning for Academic/Career/Life Success.

9:30 am—How to Choose Your Ideal Career; presented by Bill Lindstaedt. Do you want to find a The following Seminars and Workshops will be held career path that you’ll enjoy and find rewarding? Of in the EB2017 Career Center. There is no fee or course! But HOW do you find such a path, especially pre-registration associated with the workshops and since there are so many different directions scientists can go with their careers? seminars; just walk in and sit down! Sunday, April 23, 2017 9:00 am—Networking: Optimizing Your Time at EB2017; presented by Joe Tringali. You surely have heard that networking is a key component of the successful job search. The term itself often conjures up negative thoughts and reactions to the uninitiated, sometimes to the point of paralysis. Professional conferences (such as EB 2017) provide endless networking opportunities. If, however, your perception of networking means tackling someone at the coffee station while thrusting your CV in his/ her hands, you may want to stop in on this session. The practice of networking has become so much easier with the advent of the internet. We will discuss what you hope to get out of your presence at the meeting, how to set objectives beforehand, and how to meet those objectives once you arrive (while minimizing anxiety). 9:00 am—Get Up With Something On Your Mind; presented by Howard Adams. Planning for academic/career/personal success is a process—a mode of striving to excel at any and all endeavors one undertakes. It is an ongoing process of planning, reviewing, refining, adjusting and/or changing goals, strategies and tactics to realize planned outcomes— achievement, success, recognition, rewards, power, etc. This seminar is designed to encourage individual responsibility for: 1) taking charge of one’s own success; 2) focusing on being proactive; 3) being open and responsive to change; 4) applying strategies to assess one’s skills, interests, and values on an ongoing basis; and 5) building support systems through effective utilization of mentoring and networking. Key topics: The Success Mind-set, Defining Purpose, Performance Curve, The Personal Audit, Academic/

There are more than FIFTY career options available to biomedical sciences PhD’s. If you’d like to see a list of these career options, while learning about how to select the best option for you, then don’t miss this thought-provoking and interactive workshop! Here you will learn about a logical, step-by-step process for exploring your career options and deciding which will provide the best fit for your own set of skills, values and interests. 10:00 am—Negotiation Strategies for Scientists; presented by Debra Behrens. This session introduces effective methods of negotiating with potential employers. Topics: The basic elements of successful negotiation, contexts of gender and culture, avoiding common pitfalls, leveraging your strengths, handling multiple offers, and closing the deal. 10:30 am—Understanding Search Committees & Finding Job Announcements; presented by Andrew Green. Are Postdocs Always Essential? What do search committees look for? How do I find academic jobs offered in my field, or within a specific geographical area? Answers to these and other questions presented by Andrew Green, a veteran of the academic job search and numerous search committees. 1:00 pm—But I Have No Skills! Exploring Myths and Exploring Career Options for PhDs; presented by John Lombardo. Are the skills you developed in graduate training really useful outside of the academic lab? Many PhD candidates and postdocs exploring careers beyond the academy assume— incorrectly—that employers will not find them or their skills attractive. In this session you will have the opportunity to identify skills that you currently possess, and also to find career fields that might be a good fit for these skills.

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11:00 am—Making Mistakes When Speaking: How to Handle Them; presented by Judy Blumenthal. Much attention, time and money are spent on polishing our interview behaviors. But when it comes to the real thing, we frequently find ourselves saying afterwards, “I can’t believe I said that or did this.”

1:00 pm—Creating Effective CV’s, Cover Letters, Research & Teaching Statements; presented by Andrew Green. Most of the cuts in the applicant pool are made solely on the basis of your written application materials. Do yours represent you in the strongest possible fashion? How should a cover letter and CV for Stanford differ from one addressed to faculty at San Jose State? And what exactly is a Statement of Teaching Philosophy. Advice will be provided on creating these documents and more for the academic job search.

Dr. Blumenthal will teach you how to identify “triggers”, antecedents to behaviors that cause us to say things or behave in ways we wish we didn’t. She will teach you how to identify triggers before they happen and increase your chance of demonstrating the right behaviors for winning the job. 1:00 pm—Networking With Strangers Is Required for Your Future; presented by Judy Blumenthal. 1:00 pm—Job Hunting in Biotech Part 1: Finding Networking is a crucial dimension of a job offer; from & Applying for Scientist Positions; presented by developing a resume to interviewing to the job offer. Bill Lindstaedt. In this seminar, you will learn how Where do I begin? What do I take for granted? How to prepare resumes and cover letters so you will do I communicate the right behaviors for the job? And be ready to search for research jobs in the biotech/ to whom? How much of the employer’s business do pharma industry. Then, you will learn how to find and I really have to know? To be at the right place at the connect with scientists working at companies. Finally, right time, sometimes it takes just one person. But you will learn how to execute job search strategies who is this person? necessary for success on the biotech/pharma job market. After this seminar you will understand how to In this seminar, you will learn how to move in the conduct the four job hunting techniques that comprise right direction and identify and approach the right people to help you obtain a job offer. You will learn a comprehensive job search in the biotech industry. essential behaviors that promote your case and that (This is part 1 of a 3-part series. Each seminar can be can be used quite favorably. taken separately but together they provide comprehensive 2:30 pm—Networking: A Required Life Skill; information about the industry job search process.) presented by Howard Adams. To succeed in today’s 1:00 pm—Handshakes, Eye Contact, Small Talk: competitive world of work, who you know can be as Networking Successfully as a Student or Postdoc; critical as what you know. Successfully networking, presented by Naledi Saul. In this interactive session, to develop contacts, is a required skill. Networking we’ll learn how to initiate, organize and maintain your involves 1) making contacts, 2) establishing cordial network to promote your academic and professional relationships, and 3) ultimately bonding to mutually success. You will practice starting conversations support each other and share information. This seminar about your professional interests and goals, and we explores skills and techniques germane to successful will discuss professional etiquette and strategies to networking. During the session, Dr. Howard Adams network. You will also sketch your own networking will cover the following key topics: 1) Dimensions of plan for a conference. Networking; 2) Networking to enhance one’s career/ professional development; 3) Networking concerns: How? When? Where? Why? 4) Tips for Successful Networking; 5) Do’s and Don’ts of Networking.

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3:00 pm—Job Hunting in Biotech Part 2: Interviewing for Scientist Positions; presented by Bill Lindstaedt. This seminar is designed to help you improve your interview skills so that you will be better prepared to land a scientist position in industry. At the end of the seminar, you will be able to:

3:30 pm—Making the Grade: Job Talk/Chalk Talk; presented by Debra Behrens. Participants will learn to plan, structure and deliver an effective job talk. This seminar will key elements of the job talk and finally, how to capture the interest of a diverse (faculty, administrators, students) audience.

˗˗ Respond effectively to the most common 4:00 pm—Nailing the Job Talk & Interview Prep; presented by Andrew Green. Going Live: questions asked during industry interviews Conference Interviews, On-Campus Interviews, The ˗˗ Answer behavior-based questions in an All-Important Job Talk, and Negotiating the Offer. organized manner Monday, April 24, 2017 ˗˗ Begin and end the interview experience with poise and professionalism 9:00 am—Beyond the Bench: Preparing for Your Career Transition in the Life Sciences; presented (This is part 2 of a 3-part series. Each seminar by Joe Tringali. Is there a way to move your skills can be taken separately but together they provide from the bench to a related career? There is, assuming comprehensive information about the industry job one is focused and willing to invest some time in search process.) making the switch. We will explore different paths to alternative scientific careers. 3:30 pm—Networking: Optimizing Your Time at EB2017; presented by Joe Tringali. You surely 9:00 am—Goal Setting, Prioritizing, Time have heard that networking is a key component of the Management; presented by Howard Adams. Most successful job search. The term itself often conjures students have dreams and aspirations regarding up negative thoughts and reactions to the uninitiated, academic, career and life ambitions. However, too sometimes to the point of paralysis. Professional often many fall short of realizing their dreams for conferences (such as EB 2016) provide endless lack of established goals and prioritized action steps. networking opportunities. If, however, your perception So they are left with questions such as these: 1) what of networking means tackling someone at the coffee am I going to do with the rest of my life? 2) What station while thrusting your CV in his/her hands, you are my academic/career goals and objectives? and may want to stop in on this session. The practice of 3) How do I use my time wisely to get from where networking has become so much easier with the advent I am now to where I want to be in the future? This of the internet. We will discuss what you hope to get out seminar is designed to answer these questions in the of your presence at the meeting, how to set objectives context of goal setting, prioritizing, time, and stress beforehand, and how to meet those objectives once you management. Key topics: Decoding the Goals Setting arrive (while minimizing anxiety). Process, Prioritizing to Determine what is Important, Translating Goals into Time Based Action Steps, Time Management and Avoiding Procrastination, Handling Stress and Anxiety.

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10:00 am—Interviewing Well: Interviewing While Pregnant: Successful Strategies; presented by Naledi Saul. Students/postdocs who are job/postdoc seeking pregnant can find it difficult to know when and how to disclose their pregnancy during a hiring process. The decision of how and when to discuss a pregnancy a personal one; based on a candidate’s personal values, how visible their pregnancy is, their tolerance for risk, their awareness of how family friendly their potential employer is, and their level of confidence about their ability to negotiate this situation skillfully. In this interactive session, we’ll give you the information and framework to determine the best time to disclose your pregnancy during the hiring process, as well as the language to discuss your pregnancy professionally. So whether you or someone you know is presently pregnant, you are thinking about expanding your family in the future, or plan to lead a team in the future and would like to know how to manage this skillfully, this session is for you! By the end of this session, you will be able to:

10:30 am—Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions; presented by Bill Lindstaedt. So you’ve landed a job offer for an industry scientist position! Now, how do you know if the compensation package is competitive, and how do you ask for more? In this seminar you will learn how to: ˗˗ Separate out the typical components of an industry job offer letter, so you know what to ask for ˗˗ Determine if an offer is competitive and when to ask for more ˗˗ Ask for additional compensation in a way that represents your interests while maintaining positive relationships (This is part 3 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.)

10:30 am—Identifying Your Options Using ˗˗ Describe factors that make it challenging to know ScienceCareers.org, LinkedIn & More; presented when and how to discuss your pregnancy during by Andrew Green. This presentation is designed a hiring process to provide you with strategies and resources for beginning to think about what kinds of professional ˗˗ Explain the protections and limits of The options outside of academia might be a good Pregnancy Discrimination Act (PDA)/ Title VII match for your skills and interests, and how to gain of the Civil Rights Act of 1964 access to additional information about those career ˗˗ Distinguish the five stages of a hiring process, and possibilities that will help clarify which options formulate a plan about what stage to discuss your warrant further interest and investigation. pregnancy during the hiring process ˗˗ Practice the professionally appropriate language to disclose your pregnancy to an employer

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11:00 am—Developing Your Core Message/”Elevator Pitch”; presented by John Lombardo. Your core message statement is a brief spoken statement (30-second mini-abstract) about you that lets people know who you are as a professional, what you do well, and what you expect to contribute. It is a wellprepared answer to the question, “Tell me a little bit about yourself.” A positive core message statement will enhance your professional presence and stature, boost self-confidence, and reduce anxiety. It helps you establish your identity as a professional scientist, and it helps open doors for connection, collaboration, and employment. This seminar will provide guidance in a safe place to develop and practice your statement. 1:00 pm—Job Hunting in Biotech Part 1: Finding & Applying for Scientist Positions; presented by Bill Lindstaedt. (This is part 1 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Sunday’s listing. 1:00 pm—Successful Behaviors for Winning an Interview; presented by Judy Blumenthal. Eye contacts, arriving on time- these are given behaviors for any interview of any type and everyone knows them. The successful behaviors for winning an interview are those that categorize you as a high risk or low risk for the next recruitment step. In this seminar, you will learn what behaviors are important to exhibit on an interview, and how employers evaluate these behaviors to determine whether or not you are a low risk and move you on to the next recruitment step, or a high risk and don’t.

1:00 pm—Building Your Skills, Networking & Informational Interviews; presented by Andrew Green. You’ve begun to identify some potential new career paths, but how do you build on these sparks of interest, learn more about the day-to-day content of a given field, and find individuals working in that career who can answer your questions and help you build a network in your emergent profession. This presentation will discuss how to utilize Linkedln, professional associations, and other networking opportunities to increase your knowledge base and create opportunities for informational interviews. 2:30 pm—Job Search in Academia & Industry: Timelines and Effective Strategies; presented by Debra Behrens. Are you on the market for both academic and industry jobs, but aren’t sure where to start? Learn strategies for successfully navigating the two-track job search. Topics: Organizing your search, timelines/logistics, researching employer organizations, presenting your qualifications and evaluating job offers. 2:30 pm—Ten Tough Industrial Interview Questions (and Ten Pretty Good Responses); presented by Joe Tringali. You’ve been invited to interview with that drug development company that you’ve always wanted to work for. You’ve soaked up the position description, and are confident in your ability to do the job, as well as answer any/all technical questions during the interview process. The day is yours…until that first question catches you by surprise and your confidence begins to wilt. Be prepared for those non-technical questions that you will almost certainly hear at some point, know why they are asked, and learn what good (if not great) responses to those questions might be in this workshop.

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2:30 pm—Making the Case for Graduate School; presented by Howard Adams. Advanced degree level training has emerged as a key requirement for garnering positions of leadership in academia, government, and industry and for careering in today’s workplace. Beyond this, an advanced degree signal scholarship, maturity, and the capacity to do rigorous work; all attributes that can provide an edge in the workplace. This seminar explores graduate education in the context of: 1) a career enhancement strategy; 2) graduate study opportunities/options; 3) how-to negotiate the graduate school admission and financial aid process, and 4) placing graduate studies in one’s overall academic/career/life plans. Key topics: Making the Case for Graduate School, The Application/ Admissions Process, funding for Graduate Work, and Putting the Pieces Together for a Smart Application. 3:00 pm—Ten Ways to Get Lucky in the Job Search; presented by Phil Clifford & John Lombardo. Although it is important to have a plan for your career progression, it is just as important to take advantage of unexpected events along the way. This seminar will suggest specific ways to foster chance occurrences that may influence your job search. We will examine ten practical suggestions to prepare you to make happenstance work positively for you. 4:00 pm—Job Hunting in Biotech Part 2: Interviewing for Scientist Positions; presented by Bill Lindstaedt. (This is part 2 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Sunday’s listing. 4:00 pm—Making the Grade: Job Talk/Chalk Talk; presented by Debra Behrens. See description on Sunday’s listing.

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4:00 pm—Attitude & Behaviors: How Are You Perceived?; presented by Judy Blumenthal. Every person carries within them thoughts, feelings, and emotions that influence the way we are perceived by others, and the way we behave. This interaction (perceptions of others and our behavior) is so very complex, and happens so quickly, that perceptions are not necessarily at a conscious level and therefore opinions about you can be formed before you even have a chance to make any corrections to your attitude or behavior. This is a serious consequence during the job search, and a consequence we want to do without. Dr. Blumenthal will teach you how to present yourself in your resume, on the interview, and subsequent follow ups, including the job offer. She will teach you what goes on behind the scenes regarding attitudes and behaviors so that you have more leverage on your side. The end result is a positive consequence increasing the likelihood of job interviews and a job offer. Tuesday, April 25, 2017 9:00 am—Attitudes in Academic and Employment Achievement; presented by Judy Blumenthal and John Lombardo. Attitude is one of the strongest nonverbal determinants of academic and employment achievement especially in competitive settings, yet it is rarely addressed as an important behavior for applicants to focus on. Attitudes are complex circular designs since each established attitude creates a perception, which establishes an attitude, and the cycle continues. Attitude and dyadic interactions are known to be complex. Add group and panel interviews to this, and attitudes of the applicant can catapult the individual to a successful outcome, or discontinue the applicant’s competition early in the process. The authors will present a behavioral analysis of an

attitude, teach how to modify or change attitudes for success and effectiveness, and present cases they experienced pertaining to attitudes in academic and employment competition. Attendees will learn how to generalize the material to their own social function opportunities that can provide additional benefits to competition in their respective settings. They will learn highly effective attitudes and how to develop them for competitive job search and educational promotion situations for professionals.

10:30 am—Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions; presented by Bill Lindstaedt. (This is part 3 of a 3-part series. Each seminar can be taken separately but together they provide comprehensive information about the industry job search process.) See description on Monday’s listing.

10:30 am—But I Have No Skills! Exploding Myths and Exploring Career Options for PhDs; presented by John Lombardo. See description on 9:00 am—What You Seek Is What You Get; Sunday’s listing. presented by Howard Adams. It is generally agreed that sharing in a mentoring relationship can 1:00 pm—How to Choose Your Ideal Career; boost one’s career/professional/technical growth presented by Bill Lindstaedt. See description on and development. One common concern of some Sunday’s listing. professionals in today’s workplace regarding mentoring is this: “Since I am not privileged to have formal mentoring available to me, how do I find and choose a mentor on my own?” This seminar provides an overview of essential strategies for identifying, screening, selecting, and using a mentor(s). Key topics: ˗˗ Decoding the Language of Mentoring. ˗˗ Establishing Mentoring Needs and Expectations. ˗˗ Identifying, Screening, and Selecting a Mentor. ˗˗ Building a Mentorship Alliance.

1:00 pm—Talking About Yourself: How to Interview Well; presented by Naledi Saul. In this session, we will help you learn how to interview successfully, by looking at the interview process from employer’s perspective. We will discuss the overall hiring process and the all-day interview format, as well as the steps to prepare for an interview, effectively use the different types of interview questions to both present your skills and experience, and assess the employer’s needs, and criteria to ultimately determine if the position is a good fit for you.

˗˗ Developing Mentorship Goals and Action Steps. 10:00 am—Translating Your Credentials on Paper (CV=>Resume) and in Person; presented by Andrew Green. Now that you’ve completed the exploration phase, and honed in on your new professional areas of interest, how do you present yourself on paper and in-person as a compelling, credible candidate. This presentation focuses on how to transform your academic CV into an effective resume, as well as, how to write a strong cover letter and prepare for future interviews.

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1:00 pm—Navigating Doctoral Work Protocols/ Milestones/Requirements; presented by Howard Adams. Success in graduate school starts with goal setting and the formation of an action plan to achieve desired results -obtaining the degree sought. The graduate study plan should delineate 1) what is to be accomplished in terms of expectations, degree requirements, and program milestones; 2) action steps that establish priorities for tasks to be completed; 3) process for implementing action steps; and 4) time frame for meeting program requirements and milestones. Session participants will be guided through exercises and provided with templates for developing a graduate program plan. Session topics: Planning in the context of the Graduate School Process, Establishing Realistic Program Goals, Objectives, and Milestones, the Planning ProcessWriting and Implementing a Graduate Degree Plan, and Charting Milestones to Monitor Progress and Refine Actions Steps. 2:30 pm—Selling Yourself to the Life Sciences Industry; presented by Joe Tringali. The industrial employer is often looking for a different set of skills, attitudes, and interview responses than those sought by academic or government research institutions. In this workshop, we will explore the who, what and why of the pharmaceutical and biotechnology industries as they pertain to their hiring processes. Discussions will focus on the development and positioning of your marketing message in order to improve the odds of a successful industry job search.

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3:00 pm—Global Interview Skills: A Practice Workshop for International Candidates; presented by Debra Behrens. This interview practice workshop is customized for international job candidates. The key topics are: The four central questions in virtually every employment interview, understanding cultural and communication dynamics, the STAR method, and how to use “small talk” for big results. 3:00 pm—The Strategic Postdoc: How to Find & Leverage Your Postdoc Experience; presented by Andrew Green. Many PhDs just kind of fall in to a postdoc, rather than thinking about it from a strategic perspective. Your postdoc is never an end in itself; rather it’s a means to another end whether that goal is a faculty position at a research university, a small college, national lab, or perhaps an industry job. Learn how to find postdoc opportunities that will best prepare you for that next step, and how to use your postdoc experience to facilitate the transition to your next position.

FRIDAY, APRIL 21 Biochemistry and Molecular Biology 1.

ASBMB GRADUATE AND POSTDOC TRAVEL AWARD NETWORKING RECEPTION

F R I

Special Event Fri. 5:00 pm—Hyatt Regency McCormick Place, DuSable ABC Chaired: C. Heinen and T. O’Connell Start making connections with fellow Graduate Student and Postdoctoral Travel Awardees before the meeting even begins. This is also an opportunity to meet and network with many of Saturday’s Career Development Program invited presenters. Invitation only.

Nutrition 2.

FOOD SYSTEMS, NUTRITION AND HEALTH IN A CHANGING ENVIRONMENT: A WORKSHOP TO BUILD CONNECTIONS TO ADDRESS GLOBAL PRIORITIES ASN Satellite Fri. 8:00 am—McCormick Place Convention Center, S100A Chaired: J. Finley and D.J. Raiten

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Introduction to Session I: The Challenge: The Interaction of Agriculture, Environmental Change and Nutrition in Shaping Public Health: A Global Perspective. Lynnette Neufeld. Global Alliance for Improved Nutrition. 8:15 The Global Health Context: Colliding Epidemics. Daniel Raiten. Eunice Kennedy Shriver National Inst. of Child Health and Human Development. 8:40 Shaping Food and Agricultural Policy to Address Global Health. Stuart Gillespie. International Food Policy Research Inst. 9:05 Nutrition and Food Production in Transition: Impact of Changing Demographics, Economics and Personal Choice on Nutrition and Public Health. Walter Willett. Harvard T. H. Chan Sch. of Public Health. 9:30 Global Environmental Stress. Matthew Smith. Harvard T. H. Chan Sch. of Public Health. 10:55 Introduction to Session II: Meeting the Challenge: Sustainabile Food/Agriculture Solutions for Improving Nutrition and Public Health: Possibilities and Pitfalls. Barbara Schneeman. USAID.

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Avoiding Unintended Consequences. Lindsay Allen. USDA ARS Western Human Nutrition Research Ctr. 11:20 Plant-Based Food Systems: The Place of Agriculture Products within Context of a Healthy Diet. Ross Welch. Cornell Univ. 11:40 Animal-Based Food Systems: The Place of Agriculture Products within Context of a Healthy Diet. Alison Van Eenennaam. Univ. of California, Davis. 12:00 Case Study: Dairy Research: An Example of an Integrated Approach to Production, Environment and Human Health. Greg Miller. National Dairy Council. 12:35 The Agriculture/Food System: Global Status and Challenges that Impact Public Health. Sonny Ramaswamy. USDA National Inst. of Food and Agriculture. 1:20 Food Quality vs. Quantity in a Changing Population and Environment. Naomi Fukagawa. USDA-ARS. 2:25 Introduction to Session III: Considerations for Success and Engagement for Moving Forward. Dave Gustafson. ILSI Research Foundation. 2:30 Approaches to Research at the Intersection of Agriculture, Nutrition and Environment. John Finley. USDA ARS. 2:50 Agriculture-Nutrition Linkages in USG Global Food Security Program. Robert Bertram. USAID. 3:10 Big Data, the Ontology of Agriculture, Nutrition and Public Health, and Challenges of Speaking a Common Language. Sander Janssen. Wageningen Univ. and Research. 3:30 Using Public Private Partnerships to Facilitate Big Picture Research. Sylvia Rowe. SR Strategy. 4:00 Panel Discussion 5:15 Next Steps and Closing Comments. Gerald Combs. Cornell Univ.

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NUTRITION

3.

THE GLOBAL NUTRITION TRANSITION AND IMMUNE FUNCTION: THE CHALLENGES OF OVERNUTRITION AND UNDERNUTRITION IN VULNERABLE POPULATIONS

FRIDAY

ASN Satellite

CARIG FORUM: MOVING TOWARDS PERSONALIZED NUTRITION OF DIETARY CAROTENOIDS: A REVIEW OF THE GENETIC AND NON-GENETIC FACTORS IMPACTING ABSORPTION, METABOLISM, AND HEALTH IMPACTS

Fri. 8:00 am—McCormick Place Convention Center, S105BCD

Forum

Impact of Nutrition in the Global Nutrition Transition and Immune Function: The Public Health Perspective. David Heber. UCLA Ctr. for Human Nutrition. 8:45 Vitamin D and Immune Function: How Much is Enough? Michael Holick. Boston Univ. Med. Ctr. 9:15 Omega-3 Fatty Acid Modulation of Immunity, Inflammation and Cardiometabolic Disease Risk. Philip Calder. Univ. of Southampton. 10:00 Nutritional Modulation of the Microbiome and Immune Function: Where We are Today and Future Research Directions. Ian Rowland. Univ. of Reading. 10:30 Vitamin A and Carotenoids as Immunoactive Compounds. Charles Stephenson. USDA ARS Western Human Nutrition Research Ctr. 11:00 Immune Function and Micronutrient Status in Overweight and Obesity. Simin Meydani. Tufts Univ.

4.

Fri. 1:00 pm—McCormick Place Convention Center, S105A

8:00

2

Chaired: J.W. Erdman and N.E. Moran 1:15

James A. Olson Memorial Lecture: New Epidemiological Evidence on the Relationship between Carotenoids and Breast Cancer Risk. A. Heather Eliassen. Harvard Sch. of Public Health. 2:00 Introduction. John Erdman. Univ. of Illinois at Urbana-Champaign. 2:10 Genetic and Non-genetic Factors Impacting Carotene Absorption, Distribution and Metabolism. Nancy Moran. USDA ARS Children’s Nutrition Research Ctr. 2:45 Health Aspects of Carotenes. John Erdman. Univ. of Illinois at Urbana-Champaign. 3:20 Break. 3:30 Factors Impacting Xanthophyll Absorption, Distribution and Metabolism and Health Aspects of Xanthophylls. Elizabeth Johnson. Tufts Univ. 4:15 Panel Discussion: What are the Critical Variables Impacting Carotenoid Responses and What are the Critical Questions yet to be Answered? John Erdman. Univ. of Illinois at Urbana-Champaign.

SATURDAY ANATOMY

SATURDAY, APRIL 22 Anatomy 5.

IS A BALANCED TEACHING/RESEARCH CAREER FACT OR FICTION

7.

Symposium

Symposium

Sat. 1:30 pm—McCormick Place Convention Center, W175AB

Sat. 8:30 am—McCormick Place Convention Center, W176AB

Chaired: J. Feng

Chaired: L. Opperman Professional Development 8:30

The Facts and How to Plan for a Balanced Career. Lynne Opperman. Texas A&M University College of Dentistry. 8:45 Perspectives from a Chair of a Teaching Intensive Institution. Judith Venuti. Oakland University William Beaumont School of Medicine. 9:00 Perspectives from a Chair of a Research Intensive Institution. Kathryn Jones. Indiana University School of Medicine. 9:15 Achieving a Research and Teaching Balance: One Junior Faculty Member’s Experience. Margaret McNulty. Indiana University School of Medicine. 9:15 Discussion.

6.

Bones/Muscle/Connective Tissue 1:30 7.1 Osteocytes Play a Key Role in the Formation and Maintenance of Mineralized Bone. Y. Ren, J.Q. Feng. Duke University School of Medicine and Texas A&M College of Dentistry. 2:00 7.2 Osteocytes, Muscle and Exercise: Role in Healthy Aging. L. Bonewald. Indiana University. 2:30 7.3 Osteocytes Orchestrate Mechanical Signal Transduction in Bone via WNT. A. Robling. Indiana University School of Medicine.

8.

Sat. 1:30 pm—McCormick Place Convention Center, W175C Chaired: J. Organ Professional Development

Symposium

Chaired: R. Lufler Professional Development 10:30

It Takes a Village: Survival Strategies for the Tenure Track. Rebecca Fisher. University of Arizona College of Medicine-Phoenix. 10:50 Gulliver’s Conundrum: Balancing life with the Constant Productivity Pressures at Research Institutes. Paul Trainor. Stowers Institute for Medical Research. 11:10 Building Your Career and Family: How to Make Your Mark while Striking a Balance. Rebecca Lufler. Tufts University School of Medicine. 11:30 How to Stumble and Make it Look Like You’re Dancing. Jason Mussell. Louisiana State University Health Sciences Center—New Orleans. 11:50 Discussion.

STORYTELLING AND THE ART OF EFFECTIVE SCIENCE COMMUNICATION Symposium

WORK-LIFE BALANCE AND MENTAL HEALTH: HOW TO MANAGE ONE WITHOUT LOSING THE OTHER

Sat. 10:30 am—McCormick Place Convention Center, W176AB

THE MIGHTY OSTEOCYTE: NO BONE ABOUT IT

1:30 1:40

Chair’s Introduction. Connecting with Your Audience. Jonathan Rossing. Gonzaga University. 2:15 Distilling Your Message. Krista Hoffmann-Longtin. Indiana University—Purdue University Indianapolis. 2:50 Wrap-up. Jason Organ. Indiana University School of Medicine.

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S A T

ANATOMY

9.

THE ANATOMY OF CELL SHAPE

SATURDAY

11.

Symposium

Symposium

Sat. 1:30 pm—McCormick Place Convention Center, W176AB

Sat. 3:30 pm—McCormick Place Convention Center, W175AB

Chaired: T. Tootle

Chaired: M. Elsalanty

Cell Biology 1:30 9.1 Desmosomal Cadherin Association with a Dynein-Cortactin Complex Promotes Actin Rearrangements Required for Epidermal Morphogenesis. K.J. Green, O.Y. Nekrasova. Northwestern Feinberg School of Medicine. 2:00 9.2 AMPK: A Novel Link Between E-Cadherin Mechanotransduction and Cell Metabolism. K. DeMali, J. Bays, H. Miller, C. Heidema. University of Iowa. 2:30 9.3 Prostaglandins Regulate Mechanotransduction to the Nucleus. T. Tootle, E. Toombs, M. Lamb. University of Iowa.

10.

Bones/Muscle/Connective Tissue

BUILDING THE BRIDGE: CONNECTING PRIOR KNOWLEDGE TO NEW KNOWLEDGE HYBRID

3:30 11.1 Extracellular microRNA in Age-Related Bone Loss. M. Hamrick. Medical College of Georgia. 4:00 11.2 Why Does Bone Remodel, What Happens When It Doesn’t, and How Can We Use This to Change Our Therapeutic Mindset? D.B. Burr. Indiana University. 4:30 11.3 Dietary Kynurenine, the Oxidized Metabolite of Tryptophan, Suppresses Osteoprogenitor Expression of Hdac3 Resulting in Increased Marrow Adiposity and AgeRelated Bone Loss. M. McGee-Lawrence, J. Pierce, K. Yu, C. Davis, A. Dukes, Q. Zhong, J. Xu, W. Bollag, M. Elsalanty, E. Kennedy, K. Ding, W. Hill, M.W. Hamrick, C. Isales. Medical College of Georgia and University of Georgia.

Hybrid Symposium

12.

CARDIOVASCULAR BIOLOGY PLATFORM

Sat. 1:30 pm—McCormick Place Convention Center, W178A

Platform

Chaired: K. Cassidy and J.B. Barger

Sat. 3:30 pm—McCormick Place Convention Center, W175C

Education

Chaired: E. Dedkov

1:30 10.1 The Potential of Anatomy Ontology in Anatomy Education. J. Barger. University of Alabama School of Medicine. 2:00 10.2 Strategies for Enhancing Longitudinal Teaching of Anatomy Across a Revised Medical School Curriculum. A. Pearson, C.C. Pettepher, J.S. Halle, L.B. Nanney, A.F. Dalley. Vanderbilt University Medical Center and Belmont University. 2:15 Improved Medical Student Perception of Ultrasound Using a Paired Anatomy Teaching Assistant and Clinical Instructor Model. J. Smith, J. Kendall, D. Royer. University of Colorado School of Medicine. (582.23) 2:30 10.3 Previous Experience and Parental Perspectives: Influences on Study Habits in Anatomy. P. Husmann. Indiana University. 2:45 10.4 Mens Sana in Corpore Sano—A Pilot Course in Mind Body Medicine for Undergraduate Medical Students. D. Resuehr, L.T. Cotlin, S.F. Galin. UABSOM and UAB.

4

BONE REMODELING IN HEALTH, DISEASE, AND AGING

Cardiovascular Biology 3:30 Ventricular Growth and Coronary Vessel Development in the Giant Danio (Devario aequipinnatus) Heart. O. Shifatu, S. Glasshagel, P. Patel, H. Nelson, W. Tomamichel, C. Higginbotham, P.J. Lafontant. DePauw University. (586.13) 3:45 12.1 Role of Ajap1 in Cardiovascular Development. A. Poles, G. Gorski, E. Caskey, J. McEldrew, P. Ottman, C.J. Hatcher. Philadelphia College of Osteopathic Medicine. 4:00 12.2 Novel Contributions of an Extracellular Matrix Molecule to Coronary Vessel Formation. A. Bueker, A. Poles, G. Gorski, C.J. Hatcher. Philadelphia College of Osteopathic Medicine. 4:15 12.3 Genetic Lineage Tracing Analysis of Endothelial Cells in Lung Vascular Injury Identifies Two Distinct Sources of Endothelial Regeneration. M. Liu, H. Gong, L. Zhang, S. Xiong, J. Rehman, A.B. Malik. University of Illinois College of Medicine.

SATURDAY ANATOMY 4:30 12.4 Sox17-Mediated Conversion of Fibroblasts Into Endothelial Cells and Erythroblasts Enhances Neovascularization After Myocardial Infarction. L. Zhang, A. Jambusaria, Z. Hong, G. Marsboom, Y. Yuan, P. Toth, B. Herbert, A.B. Malik, J. Rehman. University of Illinois at Chicago and Indiana University School of Medicine. 4:45 12.5 HIF1α Activated Etv2 and Notch1 Signaling Biphasically Mediates ESC Differentiation to Arterial Endothelial Cells with Enhanced Sequestration in Ischemic Tissue. J. Hyun, K. Tsang, K. Cheng, M. Vargas, Y. Komarova, D. Mehta, M. Fukai, J. Rehman, A. Malik. University of Illinois at Chicago.

13.

SINGLE CELL ANALYSIS IN DEVELOPMENTAL BIOLOGY Symposium Sat. 3:30 pm—McCormick Place Convention Center, W176AB Chaired: P. Kulesa Developmental Biology/Morphology

Spatially Resolved Single-cell Transcriptomics. Jeffrey Moffitt. Harvard University. 4:00 Exploring Multi-dimensional Imaging: From Single Cell to Embryo Development. Francesco Cutrale. University of Southern California. 4:30 Single-cell Biology: Method Development and Applications on the Study of the Human Brain in Health and Disease. Spyros Darmanis. Stanford University.

14.

SO YOU WANT TO CREATE DIGITAL MEDIA FOR EDUCATION—NOW WHAT? Symposium Sat. 3:30 pm—McCormick Place Convention Center, W178A

S A T

Chaired: C. Krebs Education 3:30 14.1 If a Picture Already Tells a Thousand Words, How Many More Do We Need to Add? J. Bretschneider, Z. Rothman. VU University Medical Center Amsterdam, Netherlands and University of British Columbia, Canada. 4:00 14.2 How to create interactive digital resources that result in real learning outcomes. P. Rea, C. Krebs. University of Glasgow, United Kingdom, and University of British Columbia, Canada. 4:30 14.3 An Active Partnership: How Engaging Students as Co-Producers Will Change Your Classroom. F. Bengtson, M. Granmo. Lund University, Sweden and Linnaeus University, Sweden.

3:30

15.

WELCOME AND KEYNOTE SPEAKER Keynote Lecture Sat. 5:30 pm—McCormick Place Convention Center, W178A Welcome and introduction by AAA President, Kimberly Topp

5:30 Introduction. 5:40 15.1 Roles of Vascular Endothelial Growth Factor in Skeletal Development, Postnatal Homeostasis and Disease. B.R. Olsen, A.D. Berendsen, X. Duan, K. Hu, M. Nagao. Harvard School of Dental Medicine. 6:30 Discussion.

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BIOCHEMISTRY SATURDAY

Biochemistry and Molecular Biology 16.

ASBMB GRADUATE STUDENT AND POSTDOCTORAL FELLOW CAREER DEVELOPMENT EVENT

19.

Workshop

Special Event Sat. 8:30 am—McCormick Place Convention Center, W183C Chaired: C. Heinen and T. O’Connell Advance event registration required. Required participation by all Graduate/Postdoctoral Travel Awardees, including recipients of the Graduate Student Travel Awards supported by the ASBMB Minority Affairs Committee. Before you dig into the nitty-gritty of the very best molecular biology and biochemistry at the ASBMB annual meeting, join your peers for this day of networking, exploring careers and developing professional skills.

17.

ASBMB UNDERGRADUATE STUDENT ORIENTATION Special Event

Sat. 4:00 pm—McCormick Place Convention Center, W183AB Scientists from all career fields will meet with students and share advice about their career paths. All undergraduate students are encouraged to attend.

20.

Sat. 4:00 pm—McCormick Place Convention Center, W375C Outreach posters will be manned before and after the ASBMB Opening Lecture which takes place in the same room. Manning times: 4:00–5:15 pm and 6:30–7:00 pm. 4:00 4:00

Chaired: J. Provost

4:00

First time at a national meeting? What now? Learn how to develop a game plan to get the biggest bang for your buck during your time at the meeting.

4:00 4:00

Orientation open to all undergraduates attending the poster competition. No registration required. All ASBMB undergraduate travel award winners are required to attend.

4:00

18.

4:00

Special Event Sat. 11:30 am—McCormick Place Convention Center, W375B Chaired: K. Cornely, K. Dickson and P. Ortiz Advance competitor registration required. Competitors may check in and set up posters beginning at 11:30 (board assignments distributed at check-in). Posters must remain on display 12:30–4:00 pm. Undergraduate biochemists and molecular biologists will present their research and gain valuable practice in advance of presentations during the ASBMB annual meeting. Best Poster winners announced Sun, Apr 24, 12:30 pm, Room W184bc. Graduate program recruiters will be on hand to share exciting graduate opportunities.

6

SCIENCE OUTREACH POSTER SESSION Poster Discussion

Sat. 11:00 am—McCormick Place Convention Center, W183AB

ASBMB UNDERGRADUATE STUDENT POSTER COMPETITION

EXPLORING CAREERS SPEED NETWORKING EVENT

4:00 4:00 4:00 4:00 4:00 4:00 4:00

Board 1: CSI: Choosing Science and Innovation. B. Lehrman. Board 2: Promoting STEM awareness in East Texas: Stephen F. Austin State University ASBMB Student Chapter. C. Tovar. Board 3: Take Your Vitamins! Suffolk ASBMB Student Chapter Outreach Activities. C. Peterson. Board 4: BlastOff! with Biochemistry. G. Le. Board 5: Middle School Science Educational Outreach Programs: “Present Your Ph.D. Thesis to a 12-yearold” and “Shadow a Scientist”. G. Clark. Board 6: Project CRYSTAL (Colleagues Researching with Young Scientists: Teaching And Learning): A Scientific Outreach Program for Middle School Students. H. Holden. Board 7: Science Explorers: Small Group Mentoring/ Tutoring During the School Day to Help Underserved Chicago Public School Students Transition Into High School. J. Hatfield. Board 8: Scientific Community Outreach in Central Texas. K. Lewis. Board 9: Science in the News: Communicating science to the general public. K. Wu. Board 10: Promoting Science through a Science Club to Science Club initiative. K. Hicks. Board 11: Fostering of a Love of Science and Science Education. L. Zhao. Board 12: Teaching-learning model of science at an informal environment with an emphasis on active participation. M. Pérez-Oquendo. Board 13: Students Sharing Science: Cal Poly SLO Student Chapter Outreach. M. Hansen. Board 14: Promoting rural student enthusiasm for STEM by establishing a model biotechnology company in their high school. M. Koci.

SATURDAY BIOCHEMISTRY 4:00

4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00 4:00

21.

Board 15: Long-term research projects between students from the ASBMB student chapter at Hampden-Sydney College and Prince Edward High School, Virginia. M. Wolyniak. Board 16: Communication Training and Outreach Programs at Northwestern. M. Paulsen. Board 17: University of Texas Health Science Center at San Antonio Outreach: Meshing Science and Culture. M. Sifuentes. Board 18: “Science for the Curious” through Beer, Whiskey, Chocolate, GMOs, Pi(e), Films, and ‘Game of Thrones’. M. Metzler. Board 19: Expanding Your Horizons Connects STEM Professionals With Middle School Girls. M. Beck. Board 20: Jugando con la Ciencia—Northwestern University. N. Martinez. Board 21: New Beginnings-Our First Experience As a New ASBMB Student Chapter. P. Mullen. Board 22: Enhancing Critical Thinking Skills of High School Science Students: an Outreach Project. P. Williams. Board 23: Fired Up for Science: Engaging Community and Science Majors. T. Clark. Board 24: The ASBMB Student Chapter at Otterbein University: Best Practices and Outreach Efforts. T. Hyatt. Board 25: Discovery Outreach and The Wisconsin Science Festival—Growing a Statewide Footprint for Informal Science Engagement. W. Marner. Board 26: Outreach in New York City! The ASBMB Student Chapter at Marymount Manhattan College. A. Aguanno. Board 27: Informal STEM Education: Resources for Outreach, Engagement and Broader Impacts. C. Garibay. Board 28: “Science Fiesta!” Combining student-led community outreach with local culture. T. Block.

22.

ASBMB OPENING LECTURE: HERBERT TABOR RESEARCH AWARD Award Lecture Sat. 5:30 pm—McCormick Place Convention Center, W375C

5:30 ASBMB Business Meeting and Award Introduction. 5:45 22.1 Post-Transcriptional Regulation and the Bacterial Response to Stress. S. Gottesman. NCI, NIH.

23.

SCIENCE OUTREACH POSTER SESSION, CONTINUED Poster Discussion Sat. 6:30 pm—McCormick Place Convention Center, W375C

Outreach posters will be manned before and after the ASBMB Opening Lecture which takes place in the same room. Manning times: 4:00–5:15 pm and 6:30–7:00 pm. Refer to session 20 for presentation information.

24.

EB WELCOME RECEPTION Special Event Sat. 7:00 pm—McCormick Place Convention Center, W375DE

Join fellow attendees for our first-ever, inter-disciplinary meet and mingle and appreciate the power and energy of the EB Meeting! Light refreshments and cash bar available. Memberattendees receive one complimentary drink ticket when they sign up for the event during EB Meeting registration.

ASBMB BUSINESS MEETING Business Meeting Sat. 5:30 pm—McCormick Place Convention Center, W375C

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S A T

NUTRITION SATURDAY

Nutrition 26.

CONDUCTING A SYSTEMATIC REVIEW FOR A GLOBAL AUDIENCE: CHALLENGES IN MERGING NUTRITION AND TOXICOLOGICAL EVIDENCE FOR A SAFETY ASSESSMENT OF CAFFEINE Symposium (Sponsored by: ILSI North America) Sat. 8:30 am—McCormick Place Convention Center, S100BC Chaired: A. Kretser and D. Keefe

8:30

Welcome & Introduction. Alison Krestser. ILSI North America. 8:35 The Caffeine Landscape: Framing the Need for the Systematic Review. Dennis Keefe. US Food and Drug Administration. 8:45 Striving for the Gold Standard in the Systematic Review Process. Esther Myers. EF Myers Consulting. 9:10 The Methodology and Challenges of the Caffeine Systematic Review: An Expert Perspecive. Daniele Wikoff. ToxStrategies. 9:50 Discussion. 10:10 Break. 10:25 General Results of the Systematic Review. Daniele Wikoff. ToxStrategies. 10:35 Caffeine and Behavior. Harris Lieberman. US Army. 10:42 Caffeine and Behavior. Charles O’Brien. Univ. of Pennsylvania. 10:50 Caffeine and Reproductive & Developmental Toxicology. Jennifer Peck. Univ. of Oklahoma Health Sciences Ctr. 11:05 Caffeine & Cardiovascular Health. Daniele Wikoff. ToxStrategies. 11:20 Caffeine, Bone & Calcium. Connie Weaver. Purdue Univ. 11:35 Caffeine & Acute Toxicity & Pharmacokinetics. Milton Tenenbein. Univ. of Manitoba. 11:50 Panel Discussion with the Caffeine Systematic Review Project Team Members. Dennis Keefe.

27.

CLINICAL EMERGING LEADER AWARD ORAL COMPETITION Award Competition Sat. 9:00 am—McCormick Place Convention Center, S102BC Chaired: D. McCarron Clinical and Translational Nutrition

9:00

8

Daily Red Meat Intake Does Not Affect Improvements in Cardiovascular Disease Risk Factors Induced by Consuming the USDA’s Healthy MediterraneanStyle Eating Pattern. L.E. O’Connor, A.J. Wright, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. (966.9)

9:15

Bone Mineral Accretion Is Increased During Winter and Is Positively Related to Lean Mass Accretion and Calcium Intake in Healthy Children 2–8 y. N.R. Brett, C.A. Vanstone, H.A. Weiler. McGill University, Canada. (316.1) 9:30 The Impact of Avocado Fruit on Postprandial Satiety: An Acute Dose Response Study. Y. Huang, E. Park, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Institute for Food Safety and Health, Illinois Institute of Technology, University of California at Davis. (433.6) 9:45 Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. (447.3) 10:00 Dietary Cholesterol Lowers Risk of Type 2 Diabetes in the Framingham Offspring Study. M.M. Mott, M. Singer, M. Bradlee, L.L. Moore. Boston University School of Medicine. (167.3)

28.

POSTDOCTORAL RESEARCH AWARD COMPETITION Award Competition (Supported by DuPont Nutrition & Health) Sat. 9:30 am—McCormick Place Convention Center, S103BC Chaired: P.Y. Hsiao

9:30 9:40

Introductory Remarks. Diminished Citrulline-Arginine-Nitric Oxide Production Rates Are Associated with Necrotizing Enterocolitis Incidence in Premature Pigs. J.L. Robinson, V.A. Smith, S.M. Cruz, P.E. Lau, R. Manjarín, O.O. Olutoye, B. Stoll, J.C. Marini, D.G. Burrin. USDA/ ARS Children’s Nutrition Research Center, Baylor College of Medicine, California Polytechnic State University and Baylor College of Medicine. (164.1) 10:00 Plant-Based Diets and the Risk of Coronary Heart Disease in US Adults. A. Satija, S.N. Bhupathiraju, D. Spiegelman, S.E. Chiuve, J.E. Manson, W.C. Willett, K.M. Rexrode, E.B. Rimm, F.B. Hu. Harvard TH Chan School of Public Health, Brigham and Women’s Hospital and Brigham and Women’s Hospital. (167.4) 10:20 Oral Administration of Curcumin and Salsalate Attenuates High Fat Diet-Induced Up-Regulation of Pro-Inflammatory Colonic Cytokines and Suppresses Akt/NFκB Signaling in Azoxymethane-Treated Mice. X. Wu, A.C. Pfalzer, G. Koh, J.W. Crott, S. Tang, M.J. Thomas, M. Meydani, J.B. Mason. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Tufts Medical Center. (46.6)

SATURDAY NUTRITION 10:40 The Omega-6 to Omega-3 Fatty Acid Ratio Predicts Brain Activity During Planning Tasks in Middle Childhood. K. Sheppard, C.L. Cheatham. The Research Institute at Nationwide Children’s Hospital and University of North Carolina at Chapel Hill. (636.8) 11:00 Identification of Dietary Patterns Associated with Chronic Disease Risk Using Hybrid Dimension Reduction Techniques: Evidence from the Canadian National Nutrition Survey. M. Jessri, R.D. Wolfinger, W. Lou, M. L’Abbe. University of Toronto, Canada, North Carolina State University, University of North Carolina at Chapel Hill, Scientific Discovery and Genomics and SAS Institute. (314.4) 11:20 Transcriptome Analysis Reveals Persistent Effects of Neonatal Diet on Small Intestine Gene Expression Profile in a Porcine Model. M.K. Saraf, A.K. Bowlin, C. Chen, H. Dawson, T.M. Badger, V. Yeruva. Arkansas Children’s Nutrition Center, UAMS, USDAARS Human Nutrition Research Center and ACRI. (434.5) 11:40 Conclusion.

29.

CHILDHOOD NUTRITION EPIDEMIOLOGY Oral Sat. 10:30 am—McCormick Place Convention Center, S102D Chaired: J. Kaar and T. Crume

10:30 29.1 Dietary Intakes of the US Child and Adolescent Population and Their Adherence to the Current Dietary Guidelines: Trends from 1999 to 2012. X. Gu, K.L. Tucker. Brown University School of Public Health and University of Massachusetts Lowell. 10:45 29.2 Diet Quality Declines and Differs by Race in Early Childhood. K.A. Reynolds, H. Kalkwarf, S. Summer, P. Khoury, M. Gavin, J.G. Woo. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine. 11:00 29.3 Comparison of Fruit and Vegetable Intake from School and Packed Lunches: Intra-Individual Variation Across the School Week. J.C. Taylor, C. Sutter, L. Ontai, A. Nishina, S. Zidenberg-Cherr. University of California at Davis. 11:15 29.4 Association of Snacking Frequency with Patterning of Daily Energy Intake and Weight Among US Toddlers and Preschoolers. J.O. Fisher, A. Davey, A. Kachurak, R.K. Bailey. Temple University, University of Delaware and Purdue. 11:30 29.5 Snacking Characteristics and Patterns in the Childhood Obesity Prevention and Treatment Research Consortium. M.N. LeCroy, K.P. Truesdale, D. Matheson, A. Thomas, S. Moore, T. Robinson, S. French, J. Berge, S. Karp, H. Nicastro. University of North Carolina at Chapel Hill, Stanford University, Case Western Reserve University, University of Minnesota, Vanderbilt University, National Heart, Lung and and Blood Institute (NHLBI).

11:45 29.6 Macronutrient Composition of Early Childhood Diet Is Associated with Growth and Adiposity. T. Voortman, K.V. Braun, V.W. Jaddoe, O.H. Franco. Erasmus University Medical Center, Netherlands. 12:00 29.7 Protein Intake Is Associated with Lower Body Fat and Higher Skeletal Muscle Mass in Late Adolescence. M.M. Mott, M.R. Singer, M. Bradlee, S.R. Daniels, L.L. Moore. Boston University School of Medicine and University of Colorado School of Medicine.

30.

POLICY, SYSTEMS AND ENVIRONMENTAL APPROACHES IN PUBLIC HEALTH NUTRITION Oral Sat. 10:30 am—McCormick Place Convention Center, S103A Chaired: L. Sibeko and K. Hongu

10:30 30.1 Nutrition Facts Use by Young Adults: Predictors, Information Sought, and Relation to Dietary Intake. M.J. Christoph, N.I. Larson, M.N. Laska, D. NeumarkSztainer. University of Minnesota. 10:45 30.2 Identifying Feasible Ways for Cafeteria Operators to Comply With Calorie and Sodium Nutrition Standards in Hospitals. S. Lee-Kwan, S. Onufrak, C. Simon. Centers for Disease Control and Prevention and Partnership for a Healthier America. 11:00 30.3 Attitudes of SNAP-Approved Store Owners and Managers Regarding the Proposed USDA Rule to Strengthen Stocking Standards: A Qualitative Study in San Francisco and Oakland, California. C.W. Leung, I.H. Yen, B.A. Laraia, J.M. Tester. University of California, San Francisco, University of California, Berkeley, University of California, San Francisco and Benioff Children’s Hospital Oakland. 11:15 30.4 Impact of a Multi-Level Multi-Component Food Environment/Behavioral Intervention on Youth Leaders. A. Trude, E. Anderson Steeves, C. Shipley, P.M. Sato, L. Lachenmayr, J. Gittelsohn. Johns Hopkins University, University of Tennessee, Federal University of Sao Paulo, Brazil and Food Supplement Nutrition Education (FSNE). 11:30 30.5 Using the Wilder Collaboration Factors Inventory to Assess SNAP-Ed Coalitions in Arizona: Results from Four Counties. L. McCullough, L. Jacobs, K. Orzech, V. Farrell, D. McDonald, T. Armstrong Florian, P. Zilliox, C. Martinez, S. Misner. University of Arizona. 11:45 30.6 Development of a Healthy Eating Pattern for the Revision of Canada’s Food Guide. L. Elvidge, K. Davis, K.A. Esslinger, S. St-Pierre. Health Canada, Canada. 12:00 30.7 Does the Recent Chilean Regulation on Food Labelling Improve Chilean Population Knowledge on Nutritional Facts? A Longitudinal Comparison Between 2012 and 2016. D. Gregori, C.E. Gafare, G. Lorenzoni. University of Padova, Italy and University of Buenos Aires, Argentina. 12:15 30.8 Barriers to Healthcare Seeking and Provision Among African American Adults in the Rural Mississippi Delta: Community and Provider Perspectives. C. Connell, K. Yadrick, S. Wang. The University of Southern Mississippi and Santa Clara University.

9

S A T

NUTRITION SATURDAY

31.

OBESITY AND THE METABOLIC SYNDROME Oral Sat. 10:30 am—McCormick Place Convention Center, S103D Chaired: B. Piccolo

10:30 31.1 Neonatal Nutrition Affects Adolescent Insulin Sensitivity and the Lineage Allocation of Bone Marrow Derived Mesenchymal Stem Cells in Ossabaw Pigs. W. Zhang, R. Murray, C. Stahl. University of Maryland. 10:45 31.2 E4orf1 Protein Requires the Distal but Not Proximal Insulin Signaling to Enhance Glut4 Translocation. A. Shastri, S. Peddibhotla, Z. Feizy, V. Hegde, N.V. Dhurandhar. Texas Tech University. 11:00 31.3 Weight Loss via Alternate Day Fasting Increases Circulating Endogenous Secretory RAGE and Is Associated with Markers of Adipocyte Health. E.R. Miranda, K. Varady, J.M. Haus. UIC. 11:15 31.4 High-Sucrose Diet Time-Dependently Changes Hepatic Endoplasmic Reticulum Stress from an Adaptive to Pro-Apoptotic Pattern in Young Mice. A. ‘de Andrade Paes, K.T. Flister, P.C. dos Santos, B.A. Pinto, C.C. Vale, D. Kajihara, F.M. Laurindo, L.M. França. Federal University of Maranhão, Brazil and Heart Institute of the School of Medicine of University of São Paulo, Brazil. 11:30 31.5 Cardiometabolic Status in Obese African American Women Is Linked to Glycative Stress. S.A. Nance, A.V. Duncan, K.G. Hairston, T.M. Gwathmey. Wake Forest University School of Medicine. 11:45 31.6 A Randomized Clinical Trial in Women with Polycystic Ovary Syndrome: Effects of a Pulse-Based Diet and Exercise Intervention on Blood Lipids, Body Composition and Reproductive Measures. L.E. McBreairty, M. Kazemi, J.J. Gordon, R.A. Pierson, D.R. Chizen, P.D. Chilibeck, G.A. Zello. University of Saskatchewan, Canada. 12:15 31.7 Evenly Re-Distributing Daily Dietary Protein Intake Does Not Augment Changes in Body Composition and Cardio-Metabolic Health Indexes. J.L. Hudson, J. Kim, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. 12:30 31.8 Characterization of Spontaneous Severe Hypertriglyceridemia in Diabetic Nonhuman Primates. B.C. Hansen, J.D. Newcomb, U.C. Chaudhari. University of South Florida.

10

32.

BIOAVAILABILITY AND METABOLISM OF CAROTENOIDS AND VITAMIN A Oral Sat. 10:30 am—McCormick Place Convention Center, S104B Chaired: J. Cooperstone and E. Mohn

10:30 Chair Introduction. 10:45 32.1 Increased Study Length of Retinol Isotope Dilution with Compartmental Modeling Alters Kinetic Parameters and Calculated Vitamin A Stores. B.M. Gannon, A.R. Valentine, C.R. Davis, J.A. Howe, S.A. Tanumihardjo. University of Wisconsin-Madison, Cornell University, Oregon Health & Science University and Auburn University. 11:00 32.2 Dietary Vitamin A Dose Dependently Regulates BMP4 and WNT7A in Hair Follicles. H.B. Everts, J. Reu, J.P. Sundberg, L. Suo. Texas Woman’s University, The Ohio State University and The Jackson Laboratory. 11:15 32.3 Vitamin A Supplementation Redirects the Flow of Retinyl Esters from Peripheral to Central Organs in Neonatal Rats Raised Under Vitamin A-Marginal Conditions. J.K. Hodges, L. Tan, M.H. Green, A. Ross. Pennsylvania State University and University of Alabama. 11:30 32.4 Nutritional Changes During Biofortified Maize Fermentation (Steeping) for Ogi Production. D. Ortiz, S. Nkhata, A. Buechler, T. Rocheford, M.G. Ferruzzi. Purdue University and North Carolina State University. 13 11:45 32.5 C β-Carotene Stability During Digestion in Healthy Humans. R.E. Kopec, C. Caris-Veyrat, M. Nowicki, B. Gleize, C. Desmarchelier, P. Borel. INRA/ University of Avignon—UMR 408, France, The Ohio State University and UMR 1260 INRA/1062 INSERM/Aix-Marseille University, France. 12:00 32.6 Dose-Response Effects of Soybean Oil in Salad Dressing Upon the Bioavailability of Carotenoids/FatSoluble Vitamins in Salad Vegetables. W.S. White, Y. Zhou, A. Crane, P. Dixon, F. Quadt, L.M. Flendrig. Iowa State University, Quadt Consultancy BV, Netherlands and Unilever R&D Vlaardingen, Netherlands. 12:15 32.7 A Comparison of Lutein Bioaccumulation in Infant Rhesus Macaques Fed Breast Milk, CarotenoidSupplemented Formula, or Unsupplemented Formula. S. Jeon, K.M. Ranard, M. Neuringer, E.E. Johnson, L. Renner, M. Kuchan, S.L. Pereira, E.J. Johnson, J.W. Erdman; Jr. University of Illinois at Urbana-Champaign, Oregon Health & Science University, Abbott Nutrition and Tufts University.

SATURDAY NUTRITION

33.

YOUNG MINORITY INVESTIGATOR ORAL COMPETITION

(Supported by DSM Nutritional Products)

Do Low/No-calorie Sweeteners Help or Hurt Appetite and Weight Management? Peter Rogers. Univ. of Bristol. 12:00 Low/No-Calorie Sweeteners Influence on Gut Microbiota and Interactions of Microbiota with Stevia. Ian Rowland. Univ. of Reading.

(Sponsored by: ASN Minority and Diversity Affairs Committee)

35.

Award Competition

Sat. 11:00 am—McCormick Place Convention Center, S102BC

INFORMING B-24 DIETARY GUIDELINES: FINDINGS FROM THE NEW FEEDING INFANTS AND TODDLERS STUDY 2016

Chaired: M.D. Teran-Garcia

Symposium

11:00 The Aryl Hydrocarbon Receptor is a Repressor of Colorectal Cancer Development Induced by High-fat Diet in Mice. E.J. Garcia-Villatoro, L. Davidson, E. Callaway, K. Allred, M. Hensel, A. Jayaraman, S. Safe, R. Chapkin, C.D. Allred. Texas A&M Univ. 11:15 Toddler Formulas: Nutritional Value and Marketing Claims. M.J. Romo Palafox, J.L. Harris. Univ. of Connecticut. 11:30 Effect of a Mindful Eating Intervention on Biomarkers of Prognosis and Survival in Overweight and Obese Postmenopausal Breast Cancer Survivors: A Translational Pilot Study. A.M. Washington, M. Davis, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, B.D. Jenkins, E.L. Sattler. Univ. of Georgia. 11:45 Loss of a Healthy Weight Advantage among Foreignborn Children of Mexican Origin: An Analysis of Overweight/Obesity Trends from 1988–1994 to 2007–2014. L.E. Maldonado, S.S. Albrecht. Univ. of North Carolina at Chapel Hill. 12:00 Validity and Reliability of a Nutrition Knowledge Questionnaire for Adolescents. L.D. Ruiz, A.M. Jones, R.E. Scherr. Univ. of California at Davis. 12:15 Mechanisms Mediating Effects of Eicosapentanoic Acid in Hepatic Steatosis in High Fat Fed Mice and in HepG2 Hepatoma Cells. S.M. Gonzalez, K.M. AlbrachtSchulte, L. Ramalingam, N.S. Kalupahana, N. Moustaid-Moussa. Texas Tech Univ.

34.

12:00

STEVIA LEAF TO STEVIA SWEETENER: EXPLORING ITS SCIENCE, BENEFITS AND FUTURE POTENTIAL ASN Satellite Sat. 12:00 pm—McCormick Place Convention Center, S105BCD Chaired: P. Samuel and K. Ayoob

12:00 Introduction: A Historical Perspective on the Development of Stevia as a Sweetener. Keith Ayoob. Albert Einstein Col. of Med. 12:00 The Metabolic Fate and Safety of Stevia Leaf Extract. Berna Magnuson. Health Science Consultants. 12:00 Stevia’s Impact on Blood Glucose, Diabetes and Health. Per Bendix Jeppesen. Univ. of Aarhus. 12:00 The Naturality and Processing of Stevia Leaf Extract and Emerging New Innovations. Ursula WölwerRieck. Univ. of Bonn.

Sat. 12:30 pm—McCormick Place Convention Center, S100A 12:30 FITS 2016: An Overview of Study Design and Methodology. Andrea Anater. RTI International. 12:40 FITS 2016: An Overview of Study Design and Methodology. Diane Catellier. RTI International. 12:50 The Usual Nutrient Intakes of Infants, Toddlers and Preschoolers in the USA in 2016. Regan Bailey. Purdue Univ. 1:15 The Food Intake Patterns of Infant and Toddlers in the USA in 2016. William Dietz. George Washington Univ. 1:40 The Food Intake Patterns of Preschoolers in the USA in 2016. Mary Story. Duke Global Health Inst. 2:05 Dietary Intake Behaviors Among Infants, Toddlers, and Preschoolers Participating in the WIC Program. Joanne Guthrie. USDA ERS.

36.

GRADUATE STUDENT RESEARCH AWARD COMPETITION Award Competition Sat. 12:30 pm—McCormick Place Convention Center, S103BC Chaired: S. Adams

12:30 Dietary Depletion of Bovine Milk Exosomes Elicits Changes in Amino Acid Metabolism in C57BL/6 Mice. A.L. Leiferman, A. Aguilar, E. Mutai, J. Adamec, J. Zempleni. University of Nebraska. (135.3) 12:45 Regulation of Endogenous Dusp4 by AgonistSpecific MAPK Activation in Adipocytes. W. Guo, B.S. Ferguson, R.F. Morrison. University of North Carolina Greensboro. (644.20) 1:00 Myeloid Derived Suppressor Cells (MDSC) Are Vitamin D Targets and 1α, 25 Dihydroxyvitamin D (1,25(OH)2d) Inhibits Their Ability to Suppress T Cell Function. R.D. Calvert, G.N. Burcham, T.L. Ratliff, J.C. Fleet. Purdue University and Southern Indiana Purdue Agricultural Center. (434.8) 1:15 Vitamin E δ-Tocotrienol Inhibits NF-κB Activation by Up-Regulating A20 in Macrophages and Suppresses Colitis-Promoted Colon Tumorigenesis in Mice. C. Yang, Q. Jiang. Purdue University. (135.2) 1:30 Absorption and Excretion of Vitamin K Varies by Age and Triglycerides: A Metabolic Study in Older and Younger Adults Using Deuterium-Labeled Collard Greens. J.L. Ellis, X. Fu, A. Al Rajabi, E.N. Naumova, M.A. Grusak, E. Saltzman, S.L. Booth. Tufts University and Baylor College of Medicine. (148.3)

11

S A T

NUTRITION SATURDAY 1:45 Docosahexaenoic Acid Is More Effective Than Eicosapentaenoic Acid in Increasing the Omega-3 Index Measured in Red Blood Cell Membranes. J. Allaire, W. Harris, C. Vors, A. Tchernof, P. Couture, B. Lamarche. Institute of Nutrition and Functional Foods, Laval University, Canada, Sanford School of Medicine, University of South Dakota School of Medicine, OmegaQuant, University Institute of Cardiology and Pneumology, Canada, CHU de Québec Research Center and Laval University, Canada. (146.3) 2:00 Insulin Resistance Is Inversely Associated with the Intestinal Expression of Key Genes Involved in Chylomicron Assembly and Secretion. J. DrouinChartier, A.J. Tremblay, V. Lemelin, M. Lépine, V. Guay, B. Lamarche, P. Couture. Laval University, Canada. (137.6) 2:15 Neonatal Iron Status at Birth Is Independently Regulated by Fetally Derived Hepcidin in Neonates Born to Women Carrying Multiple Fetuses. Y. Ru, E.K. Pressman, R. Guillet, E.M. Copper, P.J. Katzman, K.O. O’Brien. Cornell University and University of Rochester Medical Center. (316.3) 2:30 Effects of Saturated Fatty Acids from Butter and Cheese on High-Density Lipoprotein (HDL)Mediated Cholesterol Efflux Capacity. D. Brassard, B. Arsenault, M. Boyer, D. Bernic, M. TessierGrenier, A. Tremblay, P. Jones, E. Levy, P. Couture, B. Lamarche. Institute of Nutrition and Functional Foods (INAF), Canada, Laval University, Canada, Québec Heart and Lung Institute, Canada, University of Manitoba, Canada, CHU Sainte-Justine Research Center, Canada and CHU de Quebec Research Center (CRCHUQ), Canada. (146.1) 2:45 Hemoglobin Response to 12 Weeks of Iron Supplementation Is Substantially Lower Among Non-Pregnant Cambodian Women with Genetic Hemoglobin Disorders. C.D. Karakochuk, M.K. Barker, S.I. Barr, S.M. Vercauteren, A.M. Devlin, K.C. Whitfield, K. Hou, K.B. Harding, L.M. De Regil, K. Kraemer, T.J. Green. University of British Columbia, Canada, BC Children’s Hospital Research Institute, Canada, BC Children’s Hospital, Canada, Mount Saint Vincent University, Canada, Helen Keller International, Cambodia, Micronutrient Initiative, Canada, Sight and Life Foundation, Switzerland and South Australian Health and Medical Research Institute, Australia. (43.5)

12

3:00

3:15

37.

Meta-Analysis of the Association of Omega-3 Fatty Acids Biomarkers with Pulmonary Function. J. Xu, T.M. Bartz, G. Eiriksdottir, A.C. Frazier-Wood, V. Gudnason, L. Lahousse, A. Manichaikul, R.R. Rohde, F. Sun, N. Terzikhan, X. Zhou, R.G. Barr, G.G. Brusselle, J. Dupuis, S.A. Gharib, S.J. London, K.E. North, B.M. Psaty, A.V. Smith, L.M. Steffen, D.B. Hancock, P.A. Cassano. Cornell University, University of Washington, Icelandic Heart Association, Iceland, Baylor College of Medicine, University of Iceland, Iceland, Ghent University, Belgium, Erasmus Medical Center, Netherlands, University of Virginia School of Medicine, University of North Carolina, Boston University School of Public Health, University of Minnesota, Columbia University, National Institute of Environmental Health Sciences, NIH, DHHS and RTI International. (167.5) Local Egg Production Centers Significantly Increase Maternal and Child Egg Consumption in Rural Zambia. S. Dumas, A.J. Travis. Cornell University. (455.7)

TRANSLATIONAL RESEARCH AWARD COMPETITION Award Competition (Sponsored by: Nutrition Translation RIS) Sat. 1:00 pm—McCormick Place Convention Center, S102BC Chaired: M. Braun

1:00 Introduction. 1:15 Stem-Like Cells in Breastmilk for Hospitalized Preterm Infants. C. Briere, T. Jensen, J.M. McGrath, C. Finck. Connecticut Children’s Medical Center, University of Connecticut and University of Connecticut Health Center. (650.33) 1:30 Salt and the City: A Preliminary Examination of New York City’s Sodium Warning Labels. S. Downs, M. Bloem, M.M. Graziose. Johns Hopkins University, Wageningen University, Netherlands and Columbia University. (302.2) 1:45 Nutrition Facts Use by Young Adults: Predictors, Information Sought, and Relation to Dietary Intake. M.J. Christoph, N.I. Larson, M.N. Laska, D. Neumark-Sztainer. University of Minnesota. (30.1) 2:00 Iron in Micronutrient Powder (MNP) May Adversely Affect the Gut Microbiome in Kenyan Infants. M. Tang, D.N. Frank, A.E. Hendricks, D.L. Culbertson, F. Esamai, N.F. Krebs. University of Colorado Anschutz Medical Campus, University of Colorado Denver, Washington University in St. Louis and Moi University School of Medicine, Kenya. (965.26) 2:15 Foodomics Application: Analysis of Dietary Components of the DASH Diet Pre and Post Consumption. Y. Nkrumah-Elie, R. Reisdorph, B. Tooker, M. Tang, L. O’Connor, S. Borengasser, R. Sayer, N. Krebs, W. Campbell, N. Reisdorph. University of Colorado, Anschutz Medical Campus and Purdue University. (437.6)

SATURDAY NUTRITION

38.

39.

PHENHRIG 2017: PLANT PHENOLICS ALTER MICROBIOME AND HUMAN HEALTH

Oral

Sat. 1:00 pm—McCormick Place Convention Center, S103A

Sat. 3:00 pm—McCormick Place Convention Center, S102BC

Chaired: T. Wilson

Chaired: M. Panasevich and T-W. Liu

ASN-NNEDPRO NUTRITION EDUCATORS DISCUSSION AND NETWORKING EVENT: TRAIN NUTRITION TRAINERS

(Supported by Abbott Nutrition) Sat. 1:00 pm—Hilton Chicago, Williford A

THE CHANGING BRAIN: HOW BRAIN PLASTICITY, EXERCISE, AND NUTRITION AFFECT FUNCTION AND COGNITION Symposium (Supported by Abbott Nutrition) Sat. 3:00 pm—McCormick Place Convention Center, S100BC

3:00 3:30 4:00 4:30

41.

Neurogenesis and Brain Plasticity in the Adult Brain. Henriette van Praag. National Inst. of Aging. The Relation of Exercise, Fitness and Adiposity to Cognitive and Brain Health. Charles Hillman. Univ. of Illinois at Urbana-Champaign. Exercise, Nutrition and Brain Function: What are the Steps Toward Dietary Recommendations? Mary Ann Johnson. Univ. of Georgia. Neuroinflammatory Processes in Cognitive Disorders: Is There a Role for Nutrients in Counteracting their Detrimental Effects? Sophie Laye. Universite Bordeaux.

ROBERT SUSKIND AND LESLIE LEWINTERSUSKIND PEDIATRIC NUTRITION LIFETIME ACHIEVEMENT AWARD Award Lecture Sat. 3:00 pm—McCormick Place Convention Center, S100A

3:00 3:40

METABOLIC PHENOTYPING, METABOLOMICS AND BIOMARKERS

Special Session

Special Session

40.

42.

3:00 42.1 Metabolomics of Coffee Consumption. M. Cornelis, I. Erlund, C. Herder, J.A. Westerhuis, J. Tuomilehto. Northwestern Feinberg School of Medicine, National Institute for Health and Welfare, Finland, Institute for Clinical Diabetology, German Diabetes Center, Germany, Swammerdam Institute for Life Sciences, University of Amsterdam, Netherlands, Department of Public Health and University of Helsinki, Finland. 3:15 42.2 Combined Metabolomic and Fluxomic Assays Suggest the Existence of Multiple Pools of Glucose6-Phosphate in Perfused Muscle. S. Previs, K. Herath, A. Petrov, J. Castro-Perez. Merck. 3:30 42.3 Serum Branched Chain and Aromatic Amino Acids Are Associated to Overweight, Obesity and Metabolic Alterations in School-Aged Children. E. Ocampo-Medina, S. Moran-Ramos, L. Macias-Kauffer, B.E. Lopez-Contreras, H. Villamil-Ramirez, P. Leon-Mimila, R. Villarruel-Vazquez, I. Ibarra-Gonzalez, M. Vela-Amieva, S. Canizales-Quinteros. National Institute of Genomic Medicine, Mexico, CONACYT, Mexico, Institute of Biomedical Research, UNAM, Mexico, National Institute of Pediatrics, Mexico, School of Chemistry and UNAM, Mexico. 3:45 42.4 Incorporation of Dietary n-3 Fatty Acids Into Selective Phosphatidylcholine Lipids in Human Plasma After Salmon Intake. P. Zacek, M. Bukowski, S. Raatz, M. Picklo. USDA ARS GFHNRC. 4:00 42.5 A Shotgun Fingerprinting Approach to Document Compliance with an Almond Consumption Intervention. J. Dhillon, C.R. Ferreira, T.J. Sobreira, R.D. Mattes. Purdue University. 4:15 42.6 Plasma Fatty Acids Patterns and Hyperlipidemia: A Prospective Study. Y. Gao, J. Zhao. Chinese Academy of Science, People’s Republic of China. 4:30 42.7 Metabolomics and Lipidomics Analysis of the NIA CALERIE Trial. B.S. Kristal, R.M. Gathungu, S.S. Bird, V.R. Marur, M.J. Sniatynski, D.P. Sheldon, C. ‘CALERIE ‘Clinical Trial Consortium. Brigham and Women’s Hospital/ Harvard Medical School and Various. 4:45 42.8 Effect of Dietary Coconut Oil and Conjugated Linoleic Acid on Liver Metabolic Phenotype in Mice. K.M. Barnes, J.P. Engle, Q. Chen, A.M. DiGregorio, J.W. McFadden. West Virginia University.

Nancy F. Krebs. Univ. of Colorado Kenneth H. Brown. Bill and Melinda Gates Foundation.

13

S A T

NUTRITION SATURDAY

43.

MEASURING AND IMPROVING MICRONUTRIENT STATUS Oral (Sponsored by: Global Nutrition Council) Sat. 3:00 pm—McCormick Place Convention Center, S102D Chaired: R. Engle-Stone and A. Palmer

3:00 43.1 Effect of the Provision of a Macro- And MicroNutrient Fortified Complementary Food Supplement on Nutritional Status of Ghanaian Infants. S. Ghosh, N. Strutt, G.E. Otoo, D.J. Suri, J. Ankrah, T. Johnson, P. Nsiah, C. Furuta, H. Murakami, G. Perera, K.K. Chui, K. Bomfeh, H.A. Kuofi, K.T. Debrah, R. Uauy. NS INF, Tufts, University of Ghana, Ghana, University of Cape Coast, Ghana, Ajinomoto Inc, Japan and INTA, Chile. 3:15 43.2 Evaluating Iron Metabolism and Supplementation in Gambian Toddlers Using a Novel, HighPrecision Method Based on the Dilution of Labelled Body Iron. D. Moretti, R. Wegmüller, C. Speich, C. Zeder, M. Cichucka, C.I. Cercamondi, A.M. Prentice, G. Brittenham, M.B. Zimmermann. ETH Zürich, Switzerland, MRC Unit, The Gambia, LSHTM, UK, Columbia University Medical Center. 3:30 43.3 Maternal Vitamin D Supplementation Significantly Improved Maternal Plasma 25(OH)D but Not Infant 25(OH)D or Bone Turnover Markers in Ethiopian Lactating Women and Their Infants. M. Girma, B. Tilahun, B. Mulugeta, F. Reta, B.J. Stoecker. Oklahoma State University and Hawassa University, Ethiopia. 3:45 43.4 Differences in Hepcidin Concentrations by Sickle Cell and α+-Thalassemia Genotype: A Cross-Sectional Study Nested Within the Kenya WASH Benefits Trial. K. Byrd, G. Rao, A. Lin, C.D. Arnold, M. Kiprotich, H.N. Dentz, T.N. Williams, A. Pickering, A.C. Null, C.P. Stewart. University of California, Davis, Innovations for Poverty Action, University of California, Berkley, Imperial College, UK, Stanford University. 4:00 43.5 Hemoglobin Response to 12 Weeks of Iron Supplementation Is Substantially Lower Among Non-Pregnant Cambodian Women with Genetic Hemoglobin Disorders. C.D. Karakochuk, M.K. Barker, S.I. Barr, S.M. Vercauteren, A.M. Devlin, K.C. Whitfield, K. Hou, K.B. Harding, L.M. De Regil, K. Kraemer,T.J. Green. University of British Columbia, Canada, BC Children’s Hospital Research Institute, Canada, BC Children’s Hospital, Canada, Mount Saint Vincent University, Canada, Helen Keller International, Cambodia, Micronutrient Initiative, Canada, Sight and Life Foundation, Switzerland and South Australian Health and Medical Research Institute, Australia. 4:15 43.6 Delaying Iron Therapy by 28 Days Is Associated with Improved Long-Term Iron Status and Equivalent Hemoglobin in Children with Severe Malaria and Iron Deficiency. S.E. Cusick, R.O. Opoka, P. Bangirana, A. Ssemata, M.K. Georgieff, C.C. John. University of Minnesota, Makerere University, Uganda and Indiana University.

14

4:30 43.7 Effects of a Micronutrient Powder Containing Low-Dose Iron and Galacto-Oligosaccharides on the Gut Microbiome and Iron Absorption: A Stable Iron Isotope Study and a Randomized Controlled Trial in Kenyan Infants. D. Paganini, M. Uyoga, C. Cercamondi, D. Moretti, C. Lacroix, S. Karanja, M.B. Zimmermann. Swiss Federal Institute of Technology, Switzerland, Jomo Kenyatta University of Agriculture and Technology, Kenya. 4:45 786.17 Impact of Provitamin A Biofortified Maize Consumption on Carotenoid Status of Zambian Children. N.E. Craft, A. Palmer, K. Schulze, J. Chileshe, M. Barffour, W. Siamusantu, R. Klemm, K. West. Craft Technologies, Inc., Johns Hopkins Bloomberg School of Public Health, Tropical Diseases Research Centre, Zambia, and National Food and Nutrition Commission, Zambia.

44.

OBESITY: ADIPOSE TISSUES AND MUSCLE METABOLISM Oral Sat. 3:00 pm—McCormick Place Convention Center, S103D Chaired: J. Alvarez

3:00 44.1 Obesity Is Associated with Increased Expression of Very Low Density Lipoprotein Receptor in Adipose Tissue: A Possible Link to Increased VLDL Catabolism and Adiposity. T. Hajri, B. Johnson, T. Talishinskiy, G. Mazpule, D. Ewing, S. Eld, R. Novack Jr, H. Schmidt. Hackensack University Medical Center. 3:15 44.2 Lipocalin-2 Is Required for Retinoic AcidInduced Beiging of White Adipocytes and Insulin-Stimulated Plasma Membrane Localization of RAR-α. J. Deis, H. Guo, D. Bernlohr, X. Chen. University of Minnesota. 3:30 44.3 Nanoparticles Encapsulated with Resveratrol Induce Browning of White Adipocytes. H. Overby, Y. Zu, S. Wang, L. Zhao. University of Tennessee Knoxville and Texas Tech University. 3:45 44.4 Regulation of Inducible Brown-Like Phenotype by Dietary 18-Carbon Fatty Acids in Mouse Adipocytes. S. Shin, K. Ajuwon. Purdue University. 4:00 44.5 Prenatal Iron Deficiency Causes Long-Term Alterations in Brown Adipose Tissue Quantity and Thermogenic Capacity in Adult Rats. S.L. Bourque, S.J. Cherak, J. Yoo, P.A. Johnson, A.G. Woodman, S. Panahi, F. Gragasin. University of Alberta, Canada. 4:15 44.6 UCP1-Null Mice Display Increased Susceptibility to Ovariectomy-Associated Metabolic Dysfunction. S.L. Clookey, R.J. Welly, T.M. Zidon, M.L. Gastecki, Z.I. Grunewald, N.C. Winn, N.G. Karasseva, H.S. Sacks, J. Padilla, V.J. Vieira-Potter. University of Missouri and UCLA David Geffen School of Medicine. 4:30 44.7 Raspberry Intake Reduces Skeletal Muscle Lipid Accumulation and Improves Insulin Sensitivity in Mice Fed High Fat Diet. M. Du, T. Zou, B. Wang, X. Liang, M. Zhu. Washington State University. 4:45 44.8 Protein-Dense Whole Food Ingestion Augments Postprandial Mitochondrial Protein Synthesis in Healthy-Weight, Overweight, and Obese Young Adults. J.W. Beals, S. van Vliet, R.A. Sukiennik, J.R. Young, A.C. Dilger, A.V. Ulanov, Z. Li, P.A. Scott, N.A. Burd. University of Illinois at Champaign-Urbana and University of Illinois.

SATURDAY NUTRITION

45.

FOOD ENVIRONMENT Oral Sat. 3:00 pm—McCormick Place Convention Center, S104A Chaired: J. Nelson-Peterman and S.A. Stotz

3:00 45.1 Healthy Food Availability and Marketing in San Francisco Small Food Stores—Differences by SNAP Vendor Status. C.W. Leung, B.A. Laraia, J.M. Tester, I.H. Yen. University of California at San Francisco, University of California at Berkeley, and University of California at San Francisco Benioff Children’s Hospital Oakland. 3:15 45.2 Analysis of Food Advertising in Children’s TV Programming. E.L. Cosenza, A. Morales-Juárez, M.F. Kroker-Lobos, S. Vandevijvere, M. Ramirez-Zea. Institute of Nutrition of Central America and Panamá (INCAP), Guatemala and University of Auckland, New Zealand. 3:30 45.3 Nutrient Declarations and Nutritional Quality of Processed and Ultra-Processed Foods Sold in Guatemala. A. Alarcon-Calderon, F. Kroker-Lobos, S. Vandevijvere, M. Ramirez-Zea. Institute of Nutrition of Central America and Panamá, Guatemala and University of Auckland, New Zealand. 3:45 45.4 Are Diets with a Lower Carbon Footprint More Nutritious? Evidence in the United States from the National Health and Nutrition Examination Survey. D. Rose, A. WillitsSmith, M. Heller, R. Meyer. Tulane University and University of Michigan. 4:00 45.5 Should the Definition of Food Deserts Incorporate a Seasonal Component? A.F. DarrouzetNardi, R.L. Boehm, S.E. Stabley. Allegheny College and Tufts University. 4:15 45.6 The Latino Tienda as Food Oasis Not Food Desert. S.M. Palmer, D.M. Winham, J.L. Baier, T.A. Roe. Iowa State University. 4:30 45.7 Disparities in Healthy Food Access: Are We Improving? R. DeWeese, P. Ohri-Vachaspati. Arizona State University. 4:45 45.8 Nutrition Resilience in the Seattle Obesity Study: How to Eat Better for Less. A. Aggarwal, J.A C. Delaney, A. Drewnowski. School of Public Health and University of Washington.

3:30 46.3 Withdrawn. 3:45 46.4 Dietary Genistein Inhibits MethylglyoxalInduced Advanced Glycation End Products Formation in HighFat Diet-Fed Mice. Y. Zhao, P. Wang, S. Sang. North Carolina A&T State University. 4:00 46.5 Effects of Lactobacillus paracasei N1115 on Intestinal Microbiota and Serum Lipid of Dyslipidemias. S. Tan, A. Zhao, Y. Zheng, P. Wang, Y. Zhang. Peking University, People’s Republic of China. 4:15 46.6 Oral Administration of Curcumin and Salsalate Attenuates High Fat Diet-Induced Up-Regulation of ProInflammatory Colonic Cytokines and Suppresses Akt/NFκB Signaling in Azoxymethane-Treated Mice. X. Wu, A.C. Pfalzer, G. Koh, J.W. Crott, S. Tang, M.J. Thomas, M. Meydani, J.B. Mason. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Tufts Medical Center. 4:30 46.7 Dietary Avicularin Alleviated Type 2 Diabetes in Mice. X. Zhu, W. Ouyang, J. Miao, P. Xiong, K. Feng, M. Li, Y. Cao, H. Xiao. South China Agricultural University, People’s Republic of China, and University of Massachusetts. 4:45 46.8 Mixture of Oleanolic Acid and Ursolic Acid Mimicked the Effects of Fructus ligustri lucidi on Calcium Kinetics, Bone Properties, and Serum 1,25(OH)2D3 in Ovariectomized Rats. M. Wong, S. Cao, M.E. Wastney, P.J. Lachcik, C. Weaver. The Hong Kong Polytechnic University, Hong Kong and Purdue University.

47.

Forum Sat. 3:30 pm—McCormick Place Convention Center, S106 Chaired: S. Mayne

48.

(Supported by The Coca-Cola Company) Sat. 5:00 pm—McCormick Place Convention Center, Hall F

EFFECTS OF DIETARY BIOACTIVE COMPONENTS IN EXPERIMENTAL MODELS OF CHRONIC DISEASE RISK Oral Sat. 3:00 pm—McCormick Place Convention Center, S104B

3:00 46.1 Eucalyptol Inhibits Diabetes-Associated Renal Fibrosis Through Blocking Epithelial to Mesenchymal Transition in Tubular Epithelial Cells Under High Glucose Stimulation. D. Kim, M. Kang, Y. Kang. Hallym University, Republic of Korea. 3:15 46.2 Seven Day Blackberry Feeding Lowers the Respiratory Quotient in Males and Improves Insulin Sensitivity. P. Solverson, W. Rumpler, J.L. Leger, B. Redan, M.G. Ferruzzi, D.J. Baer, J.A. Novotny. USDA, University of Maryland, Purdue University and North Carolina State University.

EMERGING LEADER POSTER COMPETITION Poster Award Competition

5:00

46.

COMPELLING CONVERSATIONS: FDA UPDATE ON NUTRITION INITIATIVES

5:00

Daily Red Meat Intake Does Not Affect Improvements in Cardiovascular Disease Risk Factors Induced by Consuming the USDA’s Healthy MediterraneanStyle Eating Pattern. L.E. O’Connor, A.J. Wright, D. Paddon-Jones, W.W. Campbell. Purdue University and University of Texas Medical Branch. (966.9) Ten Weeks of Protein Consumption at the RDA Results in a Loss of Appendicular Lean Mass in Healthy Older Men, a Randomized Controlled Trial. C.J. Mitchell, A.M. Milan, S.M. Mitchell, N. Zeng, F. Ramzan, P. Sharma, S. Knowles, N. Roy, A. Sjödin, K. Wagner, D. Cameron-Smith. University of Auckland, New Zealand, AgResearch, New Zealand, Copenhagen University, Denmark and University of Vienna, Austria. (139.1)

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5:00

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Identification of p-Cresol Sulfate and Secondary Bile Salts in Human Urine as Sensitive Biomarkers of Fecal Microbiota Transplantation in R-CDI Patients. Z. Bi, Y. Lu, A.R. Weigarden, D. Yao, L. Wang, A. Khoruts, M.J. Sadowsky, A. Khoruts, C. Chen. University of Minnesota. (315.1) Prefrontal Cortex Structure Mediates the Relationship Between Plasma Phospholipid Stearidonic Acid and Fluid Intelligence in Healthy, Older Adults. M.K. Zamroziewicz, E.J. Paul, C.E. Zwilling, T. Das, S. Pereira, A.K. Barbey. University of Illinois UrbanaChampaign and Abbott Nutrition. (460.1) Genistein in Combination with Fructooligosaccharides Prevents Bone Loss in Ovariectomized Rats. S. Pourafshar, N. Navaei, S.A. Johnson, S.C. Chai, S. Hooshmand, B.H. Arjmandi. Florida State University, Center for Advancing Exercise & Nutrition Research on Aging, Florida State University, Colorado State University, University of Delaware and San Diego State University. (645.9) Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. (447.3) A Year-Long Trial to Examine the Effects of a Daily Dose of Walnuts on Cardiometabolic Risk Markers in an Elderly Population. A. Al Abdrabalnabi, E. Bitok, S. Rajaram, N. Rizzo, J. Sabaté. Loma Linda University. (447.1) The Association Among Vitamin D Status, Bone Geometry and Muscle Structure in 14 to 18 y Female Adolescents with Usual Intake of Resume) & In Person. A. Green. Univ. of California, Berkeley. 10:30 Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Position. B. Lindstaedt. UCSF. 10:30 But I have no Skills! Exploring Myths & Career Options for PhDs. J. Lombardo. Med. Col. of Wisconsin and Marquette Univ. 1:00 How to Choose Your Ideal Career. B. Lindstaedt. UCSF. 1:00 Talking About Yourself: How to Interview Well. N. Saul. UCSF. 1:00 Navigating Doctoral Work Protocols/Milestones/ Requirements. H. Adams. H.G. Adams & Assoc., Norfolk, VA. 2:30 Selling Yourself to the Life Sciences Industry. J. Tringali. Tringali & Associates, Inc., Manchester, NH. 3:00 Global Interview Skills: A Practice Workshop for International Candidates. D. Behrens. Univ. of California, Berkeley. 3:00 The Strategic Postdoc: How to Find & Leverage Your Postdoc Experience. A. Green. Univ. of California, Berkeley.

TUESDAY ANATOMY

Anatomy

Chaired: H. Adesnik

9:00 386.2 Network Models: Connecting Anatomy to Systems Biology. B. Esteve-Altava. Royal Veterinary College, United Kingdom and Howard University College of Medicine. 9:30 386.3 Diversity of the Primate Musculoskeletal System: Modularity, Integration, and Anatomical Variation in Humans and Their Relatives. J.L. Molnar. Howard University College of Medicine.

Neurobiology

387. DEVELOPMENTAL BIOLOGY AWARD HYBRID

385. NEUROBIOLOGY AWARD HYBRID Hybrid Symposium Tue. 8:30 am—McCormick Place Convention Center, W175AB

C.J. Herrick Award Lecture in Neuroanatomy featuring 2017 Young Investigator Award Recipient, Florian Merkle. 8:30 385.1 The Impact of Neuroanatomy on My Career: From Adult Neurogenesis to in Vitro Disease Modelling. F. Merkle. University of Cambridge, United Kingdom. 9:00 385.2 Histopathological Changes in the Colon Accompany Dysmotility Following Experimental Spinal Cord Injury. A.R. White, T.K. Cooper, G.M. Holmes. Penn State University College of Medicine. 9:15 385.3 Promising effects of laser therapy and the natural latex protein on sciatic nerve crushed: Ultrastructural, sensory and functional study. F.J. Dias, A.B. Simões, E.d. Carmo, D.P. Cury, S.Y. Almeida, P.E. Dias, V.S. Fazan. University of Sao Paulo—Ribeirao Preto Medical School, Brazil, Universidad de La Frontera, Chile, Institute of Biomedical Sciences—Universidade de São Paulo, Brazil and School of Pharmaceutical Sciences of Ribeirão Preto—University of Sao Paulo, Brazil. 9:30 Therapeutic Effects of Long-Term Systemic Adipose-Derived Stem Cell Conditioned Medium in a Mouse Model of Amyotrophic Lateral Sclerosis. C.L. Walker, F.M. Kennedy, C.M. Fry, A.K. Iyer, Y. Du, K. March, K.J. Jones. Indiana University School of Medicine and Roudebush VA Medical Center. (744.9) 9:45 385.4 Quantification of Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, After Nociceptive Stimulation During the Neonatal Period. A.B. Simoes, G.R. Silva, E. Carmo, C. Giorgetto, V.S. Fazan. School of Medicine of Ribeirao Preto, Brazil.

386. ANATOMY IN THE 21ST CENTURY: ANATOMICAL NETWORKS AND SYSTEMS BIOLOGY Symposium Tue. 8:30 am—McCormick Place Convention Center, W175C Chaired: R. Diogo

Hybrid Symposium Tue. 8:30 am—McCormick Place Convention Center, W176AB Chaired: M. Jenkins Developmental Biology/Morphology H.W. Mossman Award Lecture in Developmental Biology featuring 2017 Young Investigator Award Recipient, Maria Barna 8:30 387.1 Specialized Ribosomes: A New Frontier in Gene Regulation, Organismal Biology, and Evolution. M. Barna. Stanford University. 9:00 387.2 A New Role of Ronin (Thap11) in the Neural Crest and Craniofacial Development in the Mouse. A. Achilleos, X. Tong, R.A. Poché. Baylor College of Medicine. 9:15 387.3 QTL Analysis of a Trade-Off in Bone Length Within the Mouse Zygomatic Arch. C.J. Percival, R. Green, D.M. Gatti, D. Pomp, C.C. Roseman, R. Marcucio, B. Hallgrímsson. University of Calgary, Canada, The Jackson Laboratory, University of North Carolina Medical School, University of Illinois and UCSF School of Medicine. 9:30 387.4 Females Are Not Proportionally Smaller Males: Relationships Between Radius Anthropometrics. M.L. Thom, J.M. Reeves, E. Lalone, K. Willmore, T.A. Burkhart. Schulich School of Medicine and Dentistry, Canada, Western University, Canada and Lawson Health Research Institute, Canada. 9:45 387.5 Inhibiting IGF1 Activity in the Proximal Tibial Growth Plate Attenuates the Bone-Lengthening Effects of Temperature in Hindlimbs of Growing Mice. H.L. Racine, C.A. Meadows, G. Ion, M.A. Serrat. Marshall University Joan C. Edwards School of Medicine.

388. PRECEDING PROFESSIONAL PROGRAMS: SUCCESSFUL ANATOMY EDUCATION IN THE UNDERGRADUATE CLASSROOM Symposium

Evolution/Anthropology

Tue. 8:30 am—McCormick Place Convention Center, W178A

Developmental Biology/Morphology

Chaired: D.C. Bentley

This session was funded and programmed in part by the AAA Innovations Program 8:30 386.1 Evo-Devo, Epigenetics, Niche Construction and the Extended Evolutionary Synthesis: Crucial Implications for Anatomical and Medical Sciences in the 21st Century. R. Diogo. Howard University.

Education 8:30 388.1 Movement Guided Learning as an Efficacious, Effective, and Evidence-Based Teaching Strategy Within the Undergraduate Anatomy Classroom. D.C. Bentley. Toronto Rehabilitation Institute, Canada.

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ANATOMY TUESDAY 9:00 388.2 Transforming a Large Anatomy Class Into a Student Centered Learning Experience. L. Mackenzie, A. Michels, L. Anstey. Queen’s University, Canada and Western University, Canada. 9:30 388.3 Strategies to Help Students Tackle Complicated Anatomical Terminology. J. Carnegie. University of Ottawa, Canada. 10:30 389.1 Prolonged Sensory Loss Results in Altered Cortico-Cortical Connectivity Patterns. P. Voss. McGill University, Canada. 11:00 389.2 An Anatomical Basis for Cortical Crossmodal Plasticity. M. Meredith, S.G. Lomber. Virginia Commonwealth University and University of Western Ontario, Canada. 11:30 389.3 Expansion of the Functional Border of the Audiovisual Cortex Following Partial Hearing Loss in Adulthood. B. Allman. University of Western Ontario, Canada.

390. CELL BIOLOGY AWARD HYBRID Hybrid Symposium Tue. 10:30 am—McCormick Place Convention Center, W175C Chaired: K. Kramer Cell Biology R.R. Bensley Award Lecture in Cell Biology featuring 2017 Young Investigator Award Recipient, Gloria Brar 10:30 390.1 Unraveling Gene Regulatory Mechanisms in Meiotic Differentiation. G. Brar, Z. Cheng, K. Van Dalfsen, A. Eisenberg, I. Hollerer. University of California-Berkeley. 11:00 390.2 Hepatic Lipolysis by β-Adrenergic Stimulation Is Inhibited by Ethanol Exposure. M. Schott, K. Rasineni, S. Weller, R. Schulze, C. Casey, M. McNiven. Mayo Clinic and University of Nebraska Medical Center. 11:15 390.3 Enhancing Plasmin Activity Prevents DietInduced Skeletal Muscle Calcification Following Injury. S.N. Moore, G.D. Hawley, B.H. Gibson, J.G. Schoenecker. Vanderbilt University. 11:30 390.4 The Consumption of Plasminogen Following Severe Burn and Its Implications in Muscle Calcification. B. Gibson, S. Moore-Lotridge, N. Mignemi, G. Hawley, W. Oelsner, J. Schoenecker. Vanderbilt University, Vanderbilt University Medical Center and Medical University of South Carolina. 11:45 390.5 Constitutive Cardiomyocyte Proliferation in the Postnatal Leopard Gecko (Eublepharis macularius). K. Jacyniak, M.K. Vickaryous. University of Guelph, Canada.

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391. MORPHOLOGICAL SCIENCES AWARD HYBRID Hybrid Symposium Tue. 10:30 am—McCormick Place Convention Center, W176AB Chaired: C. Holliday Developmental Biology/Morphology Morphological Sciences Award Lecture featuring 2017 Young Investigator Award Recipient, Shigeki Watanabe 10:30 391.1 Ultrafast Recycling of Synaptic Vesicles. S. Watanabe. Johns Hopkins University. 11:00 391.2 Malaria Derived Extracellular Vesicles Influence Human Neutrophils Function. K.A. Babatunde, M. Walch, I. Fellay, S. Kharoubi-Hess, L. Filgueira, I. Ghiran, P.Y. Mantel. University of Fribourg, Switzerland and Beth Israel Deaconess Medical Center. 11:15 391.3 Fascin Regulates Nuclear Actin During Drosophila Oogenesis. D.N. Kelpsch, C.M. Groen, T.N. Fagan, S.N. Sudhir, T.L. Tootle. Univeristy of Iowa and Mayo Clinic. 11:30 391.4 Studying Interaction of the Immune and Vascular System Using Intravital Multiphoton Microscopy. B.H. Zinselmeyer, B.T. Saunders, L. Huang, D. Runci, J.W. Williams, G.J. Randolph. Washington University School of Medicine. 11:45 391.5 Dynamic, Patient-Specific Mitral Valve Replicas for Anatomically Accurate Surgical Modelling. O. Ginty, J. Moore, D. Bainbridge, M.W. Chu, T. Peters. Western University, Canada and Robarts Research Institute, Canada.

392. ANATOMY EDUCATION PLATFORM 2— PEDAGOGY IN ANATOMY EDUCATION Platform Tue. 10:30 am—McCormick Place Convention Center, W178A Chaired: K. Metzger Education 10:30 392.1 A 50 Year Review and Meta-Analysis of Anatomy Laboratory Pedagogies. A. Wilson, C. Miller, B. Klein, M. Taylor, M. Goodwin, E. Boyle, K. Brown, C. Hoppe, M. Lazarus. Rush University Medical Center, Indiana University School of Medicine, George Washington University and Monash University, Australia. 10:45 392.2 Efficacy of Undergraduate Medical Education in Anatomical Sciences for Surgical Residency Preparation. R. Klaus, L. Lee. University of Colorado Anschutz Medical Campus.

TUESDAY ANATOMY 11:00 392.3 Does Motivation or Learning-Strategies Develop in a Flipped-Classroom? L. Day. Northeastern University. 11:15 392.4 The Long-Term Effects of an Interprofessional Education Dissection Course on Healthcare Professional Students. E. Zheng, A. Palombella, J. Salfi, I. Bayer, B. Wainman. McMaster University, Canada and Brock University, Canada. 11:30 392.5 Formative Assessments in Anatomy: Promoting Self-Directed Learning with Self-Assessment. V. Lee, K. Higgins, B. Schneider. TTUHSC. 11:45 392.6 The Relationship Between Learning and Study Strategies Inventory (LASSI) and Performance on Anatomical Sciences in Medical Schools. M.K. Khalil, H. Hawkins, S.E. Williams. University of South Carolina School of Medicine Greenville.

393. FORM AND FUNCTION PLATFORM Platform Tue. 2:00 pm—McCormick Place Convention Center, W175AB Chaired: A. Morhardt Developmental Biology/Morphology 2:00 393.1 Analysis of the Primate “Squeeze-Back” Swallowing Mechanism Using X-Ray Reconstruction of Moving Morphology and Fluoromicrometry. C.P. Orsbon, N.J. Gidmark, C.F. Ross. University of Chicago and Knox College. 2:15 Fluorescent Labeling in the Leopard Gecko Resolves Tooth Initiation Patterns in Ovo and Suggests Origins of Post-Hatching Shedding Patterns. T.M. Grieco, K.S. Brink, J.M. Richman. University of British Columbia, Canada. (743.14) 2:30 393.2 Visualizing the Anatomy and Position of the Larynx in Balaenopterid Whales. C.M. Smith, C. Ying Tang, J. Ng, J.S. Reidenberg. Icahn School of Medicine at Mount Sinai. 2:45 393.3 Free-Body Analysis of the Masticatory Muscles in a Caviomorph Rodent, Cavia porcellus. R.E. Druzinsky, A. Ulm, C.J. Vinyard, J. Iriarte-Diaz. University of Illinois at Chicago, and NEOMED. 3:00 393.4 Embryogenesis of the Nasolacrimal Apparatus in the Laysan Albatross (Phoebastria immutabilis: Procellariiformes). S.J. Rehorek, J. Cioccio, W.J. Hillenius, T.D. Smith. Slippery Rock University and College of Charleston. 3:15 393.5 Sexual Dimorphism in Bones of the Thenar and Hypothenar Aspects of the Hand. A.A. Williams, B.A. Patel, M.W. Tocheri, C.M. Orr. University of Colorado Anschutz Medical Campus, Keck School of Medicine, University of Southern California, Lakehead University, Canada, National Museum of Natural History, Smithsonian Institution, University of Colorado School of Medicine, University of Colorado at Denver.

394. DEVELOPMENTAL AND CELL BIOLOGY PLATFORM SESSION Platform Tue. 2:00 pm—McCormick Place Convention Center, W175C Chaired: R. Marcuccio Cell Biology Developmental Biology/Morphology 2:00 394.1 Investigating the Roles of Fascin in Collective Cell Migration Using Drosophila Border Cell Migration. M. Lamb, T. Tootle. University of Iowa. 2:15 394.2 Changes in Oligodendroglial and Microglial Cell Populations in the Embryonic Rat Spinal Cord Following Maternal Immune Activation. K.W. McDermott, R.C. Anderson, T. Foley, J. Radford, S. O’Halloran, G.W. O’Keeffe. University of Limerick, Ireland and University College Cork, Ireland. 2:30 394.3 Orphan Nuclear Receptor, GCNF, Is Required for Early Neural Crest Cell Induction and Survival. W.A. Munoz, S. Bhatt, J. Crane-Dennis, A. Achilleos, D. Sakai, A. Cooney, P. Trainor. Stowers Institute for Medical Research, Missouri Southern State University, Baylor College of Medicine and Doshisha University, Japan. 2:45 394.4 FoxO6 Regulates Hippo Signaling to Control Face Morphology. H. Cao, Z. Sun, C. de Fontoura, N. Holton, F. Bidlack, J. Martin, L. Moreno-Uribe, B. Amendt. The University of Iowa, The Forsyth Institute and Baylor College of Medicine. 3:00 394.5 Modular 3D Dense Surface Analysis and GWAS Reveal Localized Genetic Effects on Human Facial Morphology Involving Multiple Novel Loci. S.M. Weinberg, M. Lee, E.J. Leslie, E. Orlova, J.C. Carlson, J. Roosenboom, B.C. Mattern, C.R. Liebowitz, J.D. White, A. Zaidi, D. Hernandez, T. Gonzalez, L.N. Pearson, D. Sero, J. Li, E. Feingold, M.L. Marazita, J.R. Shaffer, J. Wysocka, M.D. Shriver, P. Claes. University of Pittsburgh, Penn State University, Katholieke Universiteit Leuven, Belgium and Stanford University. 3:15 394.6 LHX2 Is a Necessary Intermediate in FGFInduced SHH Expression During Limb Development. B.A. Watson, C.U. Pira, K.C. Oberg. Loma Linda University.

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395. STEM CELLS PLATFORM SESSION Platform

Award Lecture

Tue. 2:00 pm—McCormick Place Convention Center, W176AB

Tue. 4:00 pm—McCormick Place Convention Center, W176AB

Chaired: M. Dunnwald

Cardiovascular Biology

Stem Cells/ Regeneration 2:00 395.1 Propagating the Ovarian Cancer Stem Cells by Reprogramming the Tumor Cells. Y. Chen, C. Lu, W. Cheng, H. Ho, H. Cheng. Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taiwan, Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taiwan, Department of Obstetrics and Gynecology, College of Medicine and the Hospital, College of Medicine and National Taiwan University, Taiwan. 2:15 395.2 Spinal Cord Regeneration in the Leopard Gecko: Activation and Heterogeniety of Ependymal Layer Cells. E.A. Gilbert, M.K. Vickaryous. University of Guelph, Canada. 2:30 Contribution of Macrophages to Myxomatous Valve Disease. A. Hulin, S. Potter, A. Kim, T. DeFalco, K. Yutzey. CCHMC. (586.12) 2:45 395.3 Deformation-Induced Ingression of Transitional Pleural Myofibroblasts During Compensatory Lung Growth. A. Ysasi, R. Bennett, C. Valenzuela, A. Servais, A. Kienzle, W. Wagner, M. Ackermann, A. Tsuda, S. Mentzer. Harvard Medical School/Brigham and Women’s Hospital, Johannes Gutenberg University, Germany and Harvard School of Public Health. 3:00 395.4 Sonic Hedgehog (Shh) in Parotid Saliva Is a Cell Signaling Moiety That Acts as Stem Cells in Taste Buds to Maintain Normal Taste Function. R.I. Henkin, M. Abdelmeguid. Center for Molecular Nutrition and Sensory Disorders. 3:15 395.5 SPARC and Hevin in Mustard-Induced Skin Wound Healing. Y. Chang, H. Chang, R. Hahn, K.K. Svobada, M.K. Gordon, D.R. Gerecke. Ernest Mario School of Pharmacy, Rutgers University, and Texas A&M University, Baylor College of Dentistry.

396. LINKED MODULES IN ANATOMICAL INFERENCE: NEW APPROACHES TO MORPHOLOGICAL INTEGRATION Symposium Tue. 2:00 pm—McCormick Place Convention Center, W178A Chaired: E.R. Middleton Vertebrate Paleontology Developmental Biology/Morphology 2:00 396.1 From the Top of Your Head: Phenotypic Integration in the Head and Neck. C.I. Villamil. New York University and New York Consortium in Evolutionary Primatology. 2:30 396.2 The Modular Nature of the Trunk Skeleton in Anthropoid Primates. E.R. Middleton. University of Missouri. 3:00 396.3 Integration and Coevolution of the Mammalian Skeleton in “Real Time”: The Case of the Longshanks Mouse. C. Rolian. University of Calgary, Canada.

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397. HENRY GRAY SCIENTIFIC AWARD SYMPOSIA

4:00 Introduction. 4:05 397.1 Henry Gray Scientific Achievement Award Lecture. H. Yost. University of Utah. 4:20 Q & A.

398. HENRY GRAY DISTINGUISHED EDUCATOR AWARD SYMPOSIA Award Lecture Tue. 4:30 pm—McCormick Place Convention Center, W176AB Education 4:30 Introduction. 4:35 398.1 Getting to the Heart of Anatomical Sciences Education. W. Pawlina. Mayo Clinic College of Medicine and Science and Mayo Clinic. 4:50 Q & A.

399. A. J. LADMAN EXEMPLARY SERVICE AWARD SYMPOSIA Award Lecture Tue. 5:00 pm—McCormick Place Convention Center, W176AB 5:00 Introduction. 5:05 399.1 The Path to Anatomy via Molecular Biology. M.K. Gordon. Ernest Mario School of Pharmacy, Rutgers University. 5:20 Q & A.

TUESDAY BIOCHEMISTRY

Biochemistry and Molecular Biology 400. AVANTI AWARD IN LIPIDS Award Lecture (Sponsored by: Avanti Polar Lipids, Inc.) Tue. 8:45 am—McCormick Place Convention Center, W183AB 8:45 Introduction. 8:50 400.1 Phosphoinositide Conversion in the Endolysosomal System. V. Haucke, K. Ketel, A. Wallroth, A.L. Marat, W. Lo, C. Schultz. Leibniz Institut für Molekulare Pharmakologie, Germany and EMBL, Germany.

401. RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE AWARD Award Lecture (Sponsored by: ASBMB Minority Affairs Committee) Tue. 9:15 am—McCormick Place Convention Center, W183AB 9:15 Introduction. 9:20 401.1 From Dividing Cells to Helping Students Overcome Socio-Economic Barriers. D.N. Robinson. Johns Hopkins School of Medicine.

402. ORGANELLE TRAFFICKING AND SIGNALING Symposium Tue. 10:00 am—McCormick Place Convention Center, W183C Chaired: G.K. Voeltz 10:00 402.1 Unraveling the Mechanism of ER-Associated Organelle Fission. G.K. Voeltz. University of Colorado Boulder. 10:30 402.2 Why Mammalian Cells Respire? N.S. Chandel. Northwestern University Feinberg School of Medicine. 11:00 402.3 Nuclear Envelope Rupture Is Induced by ActinBased Nucleus Confinement. M. Hetzer, E. Hatch. The Salk Institute for Biological Studies and Fred Hutchinson Cancer Research Center. 11:30 402.4 Dynamics of Autophagy and Mitophagy in Neurons. E.L. Holzbaur. Perelman School of Medicine and University of Pennsylvania.

403. BIOCHEMICAL BASIS OF CELLULAR PROCESSES Symposium Tue. 10:00 am—McCormick Place Convention Center, W184BC Chaired: X. Wang 10:00 403.1 Dynamic Regulation of DNA Methylation. B. Zhu. Institute of Biophyisics, Chinese Academy of Sciences, People’s Republic of China. 10:30 403.2 A Novel Enzymatic DNA Modification on Methylcytosine. G. Xu. Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, People’s Republic of China. 11:00 403.3 Pyroptosis in Anti-Bacteria Immunity: Sensing and Execution. F. Shao. National Institute of Biological Sciences, Beijing, People’s Republic of China. 11:30 403.4 Mitochondrial Pathway of Apoptosis. X. Wang. National Institute of Biological Sciences, Beijing, People’s Republic of China.

404. ANTIBIOTIC RESISTANCE Symposium Tue. 10:00 am—McCormick Place Convention Center, W185BC Chaired: K. Lewis 10:00 404.1 Networks of Exchanging Antibiotic Resistance Between Environmental, Commensal, and Pathogenic Microbes. G. Dantas. Washington University School of Medicine. 10:30 404.2 Remarkable Functional Convergence: Type I and II Toxin-Antitoxins Induce Multidrug Tolerance by (p) ppGpp-Dependent Mechanisms. K. Gerdes. University of Copenhagen, Denmark. 11:00 404.3 Systems Chemical Biology: A Novel Approach to Antibiotic Discovery. D.T. Hung. Harvard and MGH. 11:30 404.4 Modeling the Gut Microbiota with Mathematical Ecology. J. Xavier. Memorial Sloan Kettering Cancer Center.

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BIOCHEMISTRY TUESDAY

405. GLYCOBIOLOGY, GLYCAN RECEPTORS AND FUNCTIONAL GLYCOMICS Symposium Tue. 10:00 am—McCormick Place Convention Center, W186ABC Chaired: N.M. Dahms 10:00 405.1 Deciphering the ZIP Codes of a Cell. N.M. Dahms. Medical College of Wisconsin. 10:30 405.2 Glycan-Binding Proteins as Microbial Detectors. L.L. Kiessling. University of Wisconsin—Madison. 11:00 405.3 O-Glycan Recognition and Function in Mice and Humans. R.D. Cummings. Beth Israel Deaconess Medical Center and Harvard Medical School. 11:30 405.4 Antibody Glycosylation: An Emerging Biomarker of Disease Activity/Protection. G. Alter. Ragon Institute of MGH, MIT and Harvard.

406. METAL HOMEOSTASIS

Special Event Tue. 12:30 pm—McCormick Place Convention Center, Hall F Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • N. Chandel, Northwestern Univ. Feinberg Sch. of Med. • V. Haucke, Leibniz Institut für Molekulare Pharmakologie, Avanti Award in Lipids • M. Hetzer, Salk Inst. for Biological Studies • E. Holzbaur, Univ. of Pennsylvania Perelman Sch. of Med. • D. Robinson, Johns Hopkins Sch. of Med., Ruth Kirschstein Diversity in Science Award • F. Shao, National Inst. of Biological Sciences, Beijing

Symposium

• G. Voeltz, Univ. of Colorado, Boulder

Tue. 10:00 am—McCormick Place Convention Center, W187ABC

• B. Zhu, Inst of Biophysics, Chinese Academy of Science

Chaired: A.C. Rosenzweig 10:00 406.1 Bacterial Copper Acquisition. A.C. Rosenzweig, G.E. Kenney, L.M. Dassama, S.Y. Ro. Northwestern University. 10:00 406.2 Mechanisms of Zinc Metallostasis in Bacterial Pathogens. D. Giedroc, D.A. Capdevila, J.E. Martin, K.A. Edmonds, H. Wu. Indiana University. 10:00 406.3 Metals and Immunity. E.M. Nolan. Massachusetts Institute of Technology. 10:00 406.4 Regulation of Manganese Homeostasis and Detoxification by the Efflux Transporter SLC30A10. S. Mukhopadhyay. The University of Texas at Austin.

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407. ASBMB MEET THE SPEAKERS

408. NIH AND NSF FUNDING OPPORTUNITIES Workshop Tue. 12:30 pm—McCormick Place Convention Center, W185BC • The Antibacterial Research and Carb-X Initiative, T. Guina and A. Sheoran, NIAID. • Alzheimers Disease Research, A. Yang, NIA, NIH. • NSF Funding Opportunities, D. Rockcliffe, Chemistry of Life Processes, NSF.

TUESDAY BIOCHEMISTRY

409. ASBMB MEET THE SPEAKERS

3:30

Special Event Tue. 1:30 pm—McCormick Place Convention Center, Hall F Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • N. Dahms, Medical Col. of Wisconsin • G. Dantas, Washington Univ. Sch. Of Med. • K. Gerdes, Univ. of Copenhagen • D. Hung, Harvard Univ. and Mass General • S. Mukhopadhyay, UT, Austin

3:45

Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study. J.N. Hackman, W. Sangster, J.P. Hegarty, K.M. Schieffer, J.R. Wright, D.R. Toole, R. Drucker, D.B. Stewart Sr., R. Lamendella. Juniata College, The Pennsylvania State University, Wright Labs and LLC. (940.8) Probiotics Alter Avian Serum Profile to Stimulate Energy Consumption and Change of Gene Expression in Immune Cells. A. Ballou, R. Ali, M. Koci. NC State University. (940.11)

411. BEYOND THE CODE: CHEMISTRY OF NUCLEOTIDE AND AMINO ACID MODIFICATIONS Symposium

• E. Nolan, MIT

Tue. 2:30 pm—McCormick Place Convention Center, W184A

• A. Rosenzweig, Northwestern Univ.

Chaired: L. Saleh

410. MICROBIOMES AND THEIR EVOLUTION DURING INFECTION AND DISEASE Symposium Tue. 2:30 pm—McCormick Place Convention Center, W183C Chaired: R. Page 2:30

Chronic Diabetic Wounds: Longitudinal Profiling of the Evolving Microbiome and Metabolic Landscape in Diabetic Patients. M.B. Ammons, A.L. Fuchs, B.P. Tripet, V. Copie, A.J. Weaver, A. Braaksma, E. Johnson, C. Yeoman. Montana State University and Bozeman Deaconess Health Hospital. (944.9) 2:45 Probiotic Escherichia coli Nissle 1917 Uses Zinc Transporters and the Siderophore Yersiniabactin to Acquire Zinc in the Inflamed Gut and Outcompete Salmonella typhimurium. J. Behnsen, J. Liu, M. Valeri, E. Hoover, J. Tjokrosurjo, N.P. Montaldo, S. Treacy-Abarca, O. Garibay, B.A. Gilston, R.A. Edwards, W. Chazin, E.P. Skaar, M. Raffatellu. University of California, Irvine, University of Illinois at Chicago, College of Medicine and Vanderbilt University. (622.6) 3:00 Bladder and Vaginal Microbiomes Have a Corresponding Shift Following Estrogen Treatment in Post-Menopausal Women. K. Thomas-White, S. Taege, D. Johansen, E.E. Hilt, C. Brincat, E.R. Mueller, L. Brubaker, A.J. Wolfe. Loyola University Chicago. (940.4) 3:15 The Metatranscriptome of the Rhesus Macaque: Investigating Potential Causes of Idiopathic Chronic Diarrhea. S.T. Westreich, A. Ardeshir, M.E. Kable, I. Korf, D.G. Lemay. University of California, Davis and USDA ARS Western Human Nutrition Research Center. (940.7)

2:30 Novel Thymidine Hypermodifications in Viruses Encoding a 5-Hydroxymethyl-5′-Deoxyuridine DNA Kinase. P.R. Weigele, S. Müller, Y. Lee, S. Walsh, C. Guan, N. Dai, I. Correa. New England Biolabs. (606.6) 2:45 A Shared Structural Recognition Element in mRNA Substrates of the tRNA Modifying Enzyme Pseudouridine Synthase 1. T.M. Carlile, T.A. Bell, M.F. Rojas-Duran, B. Zinshteyn, H. Shin, C. Mason, W.V. Gilbert. MIT. (595.3) 3:00 In Vitro Development of Synthetic Chromatin Proteins That Function in Live Cells. K.A. Haynes, S. Tekel, D.A. Vargas. Arizona State University. (922.8) 3:15 Deciphering the Logic of Natural Product Biosynthesis. B. Li. University of North Carolina at Chapel Hill. (607.9) 3:30 New Roles for Dithiolopyrrolones in Disrupting Bacterial Metal Homeostasis and Inhibiting Metalloenzymes. A.N. Chan, A.L. Shiver, W.J. Wever, S.Z. Razvi, M.F. Traxler. University of North Carolina at Chapel Hill, University of California at San Francisco, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Duke University, University of California at Berkeley. (766.15) 3:45 YTHDC2 Regulates Spermatogenesis Through Promoting the Translation of N6-MethyladenosineModified RNA. P.J. Hsu, Y. Zhu, H. Ma, Y. Cui, X. Shi, G. Luo, Z. Lu, H. Shi, Q. Dai, M. Clark, B. Shen, C. He. The University of Chicago, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, People’s Republic of China. (595.10)

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412. MOLECULAR MECHANISMS OF REGULATION IN PROTEOLYSIS Symposium Tue. 2:30 pm—McCormick Place Convention Center, W184BC Chaired: E.S. Radisky 2:30 412.1 Substrate Conformational Dynamics in Proteolysis. E.S. Radisky. Mayo Clinic Cancer Ctr. 2:45 Phosphorylation Regulates Apoptotic Caspase Function Through Diverse Molecular Mechanisms. J.A. Hardy, B.P. Serrano, S.J. Eron. University of Massachusetts. (602.3) 3:00 Proteasome Activation via a Functional Switch of the Rpt6 C-Terminal Tail Following Chaperone-Dependent Assembly. S. Park, F. Li, V. Sokolova. University of Colorado Boulder. (917.4) 3:15 Structure of hRpn13 at the Proteasome. X. Lu, F. Liu, U. Nowicka, V. Sridharan, M. Dyba, S.G. Tarasov, K.J. Walters. Center for Cancer Research, National Cancer Institute. (603.5) 3:30 The Intrinsically Disordered Membrane Enzymes Selenoprotein S and Selenoprotein K. S. Rozovsky, J. Liu, Z. Zhang. University of Delaware. (773.1) 3:45 The Cellular Demand for Protein Synthesis Influences the Ribosome Maintenance Program in Vivo. J.C. Price. Brigham Young University. (759.4)

413. RNA: SYNTHESIS, REGULATION, AND PROCESSING Symposium

3:15 Activation of Transcription-Coupled 5′RNA Capping by TFIIH. M. Noe-Gonzalez, J. Conaway, R. Conaway. Stowers Institute and Kansas University Medical Center. (907.1) 3:30 The Role of the Essential Splicing Factor Prp2 in Ribosome Biogenesis. S. Edwards, A. Hossain, T. Johnson. University of California at Los Angeles. (596.13) 3:45 Nonstop Decay in C. elegans: Examination of a Possible Role for Small Noncoding RNAs. E.M. Youngman. Villanova University. (757.21)

414. THERAPEUTICS: TARGETS AND DESIGN Symposium Tue. 2:30 pm—McCormick Place Convention Center, W185BC Chaired: K. Dalby 2:30

2:45

3:00 3:15

Tue. 2:30 pm—McCormick Place Convention Center, W185A Chaired: C. Kaplan 2:30 413.1 Mechanism and Regulation of RNA Polymerase II. C.D. Kaplan. Texas A&M. 2:45 Inhibiting Pathways Involved in B-Cell Development Enhances Sensitivity of B-Cell Acute Lymphoblastic Leukemia to Glucocorticoids. M.A. Pufall, K. Kruth, M.A. Fang, D. Shelton, O. Abu-Halawa, S.K. Tasian, M. Kampmann. University of Iowa, Bio-Rad, Coe College, Children’s Hospital of Philadelphia, University of California San Francisco. (756.20) 3:00 Regulation of RNA Polymerase Translocation by the RNA and DNA Hybridization at the Upstream Edge of the Transcription Bubble. M. Kireeva, C. Trang, G. Matevosyan, L. Lubkowska, M. Kashlev. NCI. (597.3)

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3:30

3:45

Mechanism and in Vivo Activity of a Covalent Inhibitor of ERK Docking. K.N. Dalby, E.V. Anslyn, D. ZamoraOlivares, T. Kaoud. University of Texas at Austin. (608.13) Elucidation of the Cell Death Pathways Induced by Aqueous-Stable Titanium(IV) Compounds as Potential Anticancer Agents. Y. Delgado, A. Vázquez, M. Kowaleff, M. Saxena, Z. Torres, A. Tinoco. University of Puerto Rico Rio Piedras Campus and City University of New York. (609.12) In Vivo Drug Discovery for Progressive Supranuclear Palsy Using a Novel Zebrafish Model. E.A. Burton, Q. Bai. University of Pittsburgh. (609.13) Insight Into the Mechanism and Structural Basis for Autoinhibition of PTEN by Phosphorylation of Its C-Terminal Tail. D.R. Dempsey, Z. Chen, S. Thomas, D. Hayward, D. Bolduc, P. Cole. Johns Hopkins University. (771.1) Trehalose-6-Phosphate Phosphatase Structure and Inhibitor Design. C. Harvey, C. Liu, D. Globisch, K. Janda, D. Dunaway-Mariano, K. Allen. Boston University, University of New Mexico and The Scripps Research Institute. (923.5) Carbohydrate-Linked Cisplatin Analogue: Reactivity Studies with RNA and DNA. S.D. Thalalla Gamage, N. Muthunayake, A. Sonousi, D. Crich, C. Chow. Wayne State University. (608.8)

TUESDAY BIOCHEMISTRY

415. THE INTEGRATION OF METABOLISM AND EPIGENETICS

2:45

Symposium Tue. 2:30 pm—McCormick Place Convention Center, W186ABC

3:00

Chaired: M. Hirschey 2:30 415.1 Epigenetic Control of Gene Expression by Lipid Metabolism. M. Hirschey. Duke Univ. 2:45 Regulation of Histone Methylation via Methionine Metabolism. S.A. Haws, J.M. Denu. University of Wisconsin-Madison, Wisconsin Institute for Discovery and University of Wisconsin-Madison School of Medicine and Public Health. (755.9) 3:00 Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. D. Zhang, Z. Xie, D. Chung, Z. Tang, H. Huang, L. Dai, S. Qi, J. Li, G. Colak, Y. Chen, C. Peng, H. Ruan, D. Wang, L.M. Jensen, O. Kwon, S. Lee, S.D. Pletcher, M. Tan, D.B. Lombard, K.P. White, H. Zhao, J. Li, R.G. Roeder, X. Yang, Y. Zhao. Medical University of South Carolina, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China, University of Minnesota Twin Cities, Yale University School of Medicine, University of Michigan, Kyungpook National University, Republic of Korea, Yale University and Yale School of Medicine. (755.2) 3:15 Hepatic Fat Accumulation Regulates Carnitine Palmitoyltransferase 1 (Cpt1a) Expression Through Coordinated Epigenetic Mechanisms. L. Moody, P.M. Jung, A. Kriska, H. Chen, Y. Pan. University of Illinois Urbana Champaign. (625.1) 3:30 Obesity-Mediated Regulation of the Cardiac Acetylome. S.S. Romanick, A. Hostler, K. Schlauch, D. Quilici, Y. Feng, B. Ferguson. University of Nevada Reno. (602.14) 3:45 Effects of Acute Aerobic Exercise on Whole Genome Nucleosome Maps and Gene Expression in Skeletal Muscle of Lean vs Overweight/Obese Men. P.M. Devarshi, A.D. Jones, W.W. Campbell, E.M. Taylor, T.M. Henagan. Purdue University. (943.3)

416. INTRINSIC DISORDER AND RECOGNITION Symposium Tue. 2:30 pm—McCormick Place Convention Center, W187A

3:15

3:30

3:45

BECN Homologs and ATG14 Form a Metastable CoiledCoil to Mediate Autophagy. S. Sinha, M. Su, Y. Li, B. Levine, C. Colbert. North Dakota State University, Howard Hughes Medical Research Institute and University of Texas Southwestern Medical Center. (760.24) Fis1 Activity in Pre- and Post-Assembly of the Yeast Mitochondrial Fission Machinery. M.C. Harwig, R.B. Hill. Medical College of Wisconsin. (634.8) The Conformation of Apolipoprotein E4 on Discoidal and Spherical High Density Lipoproteins Using Chemical Crosslinking and Fluorescence Spectroscopy. N. Bala, K. Taiwo, V. Narayanaswami. California State University at Long Beach. (761.26) Insights Into HuR RRM1-2 Tandem Domains SelfAssociation and mRNA Recognition. A.S. Pinheiro, C. Lixa, K.A. Jendiroba, L.T. Lima, M.T. de Magalhães, F.C. Almeida. Federal University of Rio de Janeiro, Brazil and Federal University of Minas Gerais, Brazil. (598.5) Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Y. Lin. University of Texas Southwestern Medical Center. (760.4)

417. NUTRITION IMPACT ON BACTERIA AND HOST HEALTH: FROM BASIC SCIENCE TO GLOBAL VIEW Symposium (Guest Society: Society for Experimental Biology and Medicine) Tue. 3:00 pm—McCormick Place Convention Center, W184D Chaired: C. Allred 3:00 3:10

Chair’s Introduction. Microbial Tryptophan Metabolites and Gut Health. A. Jayaraman. Texas A&M University. 3:35 Host-Microbe Interactions in the Human Infant: Impact of Nutrition. S. Donovan. University of Illinois. 4:00 Legumes and gut health. M. Manary. Washington University. 4:25 Diet Drives Colon Cancer Risk by its Effect on the Microbiota. S. O’Keefe. University of Pittsburg Medical Center. 4:50 Discussion.

Chaired: B. Hill 2:30

Multidimensional Chemical Control of CRISPR-Cas9. C.L. Moore, B. Maji, A. Choudhary, M. Shoulders. MIT, Broad Institute and Harvard Medical School. (909.5)

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418. ADVANCES IN GLYCOBIOLOGY Symposium Tue. 4:15 pm—McCormick Place Convention Center, W183C Chaired: K. Ribbeck 4:15 418.1 Probing Microbial Interactions with the Mucus Barrier. K. Ribbeck. MIT. 4:30 Bifidobacterium dentium Regulates Intestinal Mucus Production and Glycosylation. M.A. Engevik, B.K. Luk, C. Visuthranukul, J. Versalovic. Baylor College of Medicine, Texas Children’s Hospital and King Chulalongkorn Memorial Hospital, Thailand. (954.5) 4:45 Microbiota-Sensing O-GlcNAc Signaling in Intestinal and Metabolic Homeostasis. H. Ruan, M. Zhao. University of Minnesota. (784.4) 5:00 Toward Facile Automated Glycan Synthesis: Current Progress and Remaining Challenges. N.L. Pohl. Indiana University. (784.10) 5:15 Glycolipid Storage and Phenotypes in a New Rat Model of Fabry Disease. J.J. Miller, K. Aoki, C.A. Murphy, C.L. Stucky, I.S. Kassem, M. Tiemeyer, N.M. Dahms. Medical College of Wisconsin and University of Georgia. (953.2) 5:30 Imaging Specific Glycan Epitopes on Cells Using Glycosyltransferases via Click Chemistry. Z.L. Wu, A. Person, M. Anderson, B. Burroughs, R. Sackstein, T. Geders. Bio-techne, Brigham & Women’s Hospital and Harvard Medical School. (784.7)

419. CHEMICAL PROBES AND METABOLITE BIOSENSORS Symposium Tue. 4:15 pm—McCormick Place Convention Center, W184A Chaired: M. Hirschey 4:15 4:30

4:45

130

Designing Highly Specific Protein-Based Small Molecule Biosensors. S. Raman. University of WisconsinMadison. (765.3) Development of Algorithmic Techniques for Designing Electrochemical DNA Biosensors. A.J. Bonham, A.J. Bulow. Metropolitan State University of Denver. (767.2) Development of Red Fluorescent Protein pH Sensors. M. Rajendran, E. Haynes, B. Claywell, U. Scales, C. Henning, M. Tantama. Purdue University. (767.3)

5:00

Sensitive and Specific Detection of Ligands Using Engineered Riboswitches. J.P. Laney, D.P. Morse. United States Naval Academy. (907.4) 5:15 Bead-Based Enzymatic Assay On-A-Chip. S.J. Karnik, S. Cahoon, A. Bhushan. Illinois Institute of Technology. (924.5) 5:30 Lanthanide-Based FRET Biosensors for Time-Gated Imaging and Detection of Protein-Protein Interactions in Live Mammalian Cells. T. Chen, H. Pham, L. Miller. UIC. (767.6)

420. CANCER SIGNALING AND THERAPEUTICS Symposium Tue. 4:15 pm—McCormick Place Convention Center, W184BC Chaired: K. Wood 4:15

Leveraging Synthetic Lethality to Target Convergent Therapeutic Resistance. K.C. Wood. Duke University. (775.4) 4:30 CEBPD Is an Early Endoplasmic Reticulum Stress Response Gene Implicated in Breast Cancer Cell Survival. N. Sheshadri, S. Sharan, E. Sterneck. National Cancer Institute. (758.2) 4:45 Manipulating the Bone Marrow Microenvironment to Prevent Survival of AML Cells. R.M. Sterner, K.N. Kremer, A. Dudakovic, J.J. Westendorf, A.J. van Wijnen, K.E. Hedin. Mayo Clinic. (775.3) 5:00 Deconstructing the Peptide Specificity of TCR Recognition. T.P. Riley, J. Mendoza, L. Hellman, K. Garcia, B. Baker. University of Notre Dame and Stanford School of Medicine. (760.1) 5:15 Mortalin Modulates MEK/ERK Activity by Regulating the Physical Interaction Between MEK1/2 and Protein Phosphatase 1 Alpha. P. Wu. Medical College of Wisconsin. (775.1) 5:30 At the Crossroads Between TYR and SER/THR Signaling: A New Paradigm in the Regulation of PP2A by SRC Kinase. E. Sontag, J. Sontag, R.J. Gomez, A. Hoffman, G. Taleski, M.D. Mazalouskas, S.K. Hanks, I. Frohner, E. Ogris, B.E. Wadzinski. University of Newcastle, Australia, Vanderbilt University School of Medicine and Medical University of Vienna, Austria. (771.2)

TUESDAY BIOCHEMISTRY

421. CHROMATIN STRUCTURE AND EPIGENETIC REGULATION Symposium Tue. 4:15 pm—McCormick Place Convention Center, W185A Chaired: P. Grant 4:15 421.1 The Replication Kinase Cdc7 Marks Histones to Regulate Biosynthesis Genes. P. Grant. University of Virginia School of Medicine. 4:30 Chromatin Accessibility of the Dosage Compensated Drosophila Male X-Chromosome Is Established by a Context-Specific Role for the CLAMP Zinc Finger Protein. E. Larschan, J. Urban, G. Kuzu. Brown University. (593.10) 4:45 Epigenetic Manipulation of Inactive X Chromosome for Rett Syndrome Therapeutics. S. Bhatnagar. University of Virginia School of Medicine. (593.4) 5:00 Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J.K. Low, A.P. Silva, M. Sharifitabar, M. Torrado, J. Schmidberger, S.R. Webb, H. Saathoff, B.L. Parker, B. Paudel, A. van Oijen, M.J. Landsberg, N.E. Shepherd, J.P. Mackay. The University of Sydney, Australia, The University of Wollongong, Australia and The University of Queensland, Australia. (594.3) 5:15 Role of Chromatin Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination Mediated Gene Silencing. H. Wang, Z. Zhang, A.E. Jones, M.B. Renfrow, C. Liu, W. An, J. Luo, W. Wu, Y. Kang, Y. Tong. University of Alabama at Birmingham, Nanyang Technological University, Singapore, University of Southern California, Chinese Academy of Sciences, People’s Republic of China, and University of Toronto, Canada. (593.6) 5:30 Epigenetic Regulation Through UHRF Proteins. S.B. Rothbart, R.M. Vaughan, E.M. Cornett, B.M. Dickson. Van Andel Research Institute. (595.4)

422. LIPID TRANSPORT AND PROCESSING Symposium Tue. 4:15 pm—McCormick Place Convention Center, W186ABC Chaired: A. Radhakrishnan 4:15

4:30

Probing the Lipid Composition at the Site of Influenza Virus Assembly and Budding with HighResolution SIMS. M.L. Kraft, A.N. Yeager, P.K. Weber, J. Zimmerberg. University of Illinois at Urbana-Champaign, Lawrence Livermore National Laboratory, National Institute of Child Health and Human Development, National Institutes of Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development. (629.20) Macrophage Catabolism of Aggregated Lipoproteins Using a Novel Extracellular Compartment Regulates Lipid Accumulation During Atherosclerosis. R.K. Singh, A.S. Haka, V.C. Barbosa-Lorenzi, A. Asmal, F. Lund, Y. Xiong, H.F. Chin, I. Grosheva, T. Hla, F.R. Maxfield. Weill Cornell Medical College. (782.17)

4:45

5:00

5:15

5:30

Macrophage Cholesterol Efflux and Atherosclerosis in Psoriasis: A Role for microRNA-33. D. Karunakaran, G. Dwevidi, K. Rayner. University of Ottawa Heart Institute, Canada. (947.7) Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection. F. Lu, M. Brown, J. Goldstein. University of Texas Southwestern Medical Center. (630.17) Ceramide-1-Phosphate: Characterizing a Fluorescent Lipid and Discovering New Binding Proteins. C.M. Shirey, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend. (629.24) A Novel Hemolysin with Anti-Cancer and Anti-Fungal Properties Binds to Serum Glycoproteins and Cholesterol. C. Welch, N. Fan, R. Brown, M. Talaga, A. Fueri, K. Driscoll, K. Lawry, A. Vizurraga, R. Rekhi, P. Bandyopadhyay, T. Dam. Michigan Technological University. (953.4)

423. MOLECULAR MACHINES OF PROTEIN SYNTHESIS AND DEGRADATION

T U E

Symposium Tue. 4:15 pm—McCormick Place Convention Center, W187A Chaired: K. Walters 4:15

ALS and Ubiquilin-2: Effects of ALS Mutations on Ubiquilin-2 Structure and Function. C. Castaneda, T. Dao. Syracuse University. (914.11) 4:30 Repeat Expanded Ataxin-1 mRNA and Protein Is CoRegulated at PML Bodies. D. Fanslow, A. Cogswell, C. Strojny, A. Garza-Gongora, E. Smith, S. Kosak. Northwestern University. (915.7) 4:45 Inter-Domain Interactions in Nascent Polypeptides Interfere with Productive Protein Folding. K. Liu, K. Maciuba, C. Kaiser. Johns Hopkins University. (604.10) 5:00 A Neuronal-Specific Surface-Exposed Membrane Proteasome Complex Modulates Neuronal Signaling Through Extracellular Signaling Peptides. K.V. Ramachandran, S.S. Margolis. Johns Hopkins School of Medicine. (915.4) 5:15 Nitrogen Starvation and Rapamycin Both Induce Autophagic Degradation of Proteasome Complexes. J. Roelofs, K.A. Waite, G. Vontz, A. De La MotaPeynado. Kansas State University. (917.6) 5:30 Multivalent Interactions Between a Ubiquitin Ligase and Its Substrates Mediate Their Recruitment to Liquid Membrane-Less Organelles. T. Mittag, J. Bouchard, E. Martin, J. Otero, S. Marada, S. Ogden. St. Jude Children’s Research Hospital. (916.3)

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424. PROTEIN AND ENZYME ALLOSTERY Symposium

426. PUBLISHING IN THE JBC 101: ADVICE FROM THE EXPERTS

Tue. 4:15 pm—McCormick Place Convention Center, W187B

Workshop

Chaired: W. Peti

Tue. 6:15 pm—McCormick Place Convention Center, W185BC

4:15

Using Dynamics and Structure to Understand Allostery in Signaling Enzymes. W. Peti. University of Arizona. (607.2) 4:30 Allosteric Landscape of a Stress-Inducible Human Hsp70 Molecular Chaperone. W. Meng, E.M. Clerico, N. McArthur, L.M. Gierasch. University of Massachusetts and Amherst. (604.14) 4:45 A Common Mechanism of Proteasome Impairment by Neurodegenerative Disease-Associated Oligomers. T.A. Thibaudeau, R. Anderson, D.M. Smith. West Virginia University and School of Medicine. (763.8) 5:00 Phospholipase A2: A Unique Paradigm of Allosteric Regulation by Membranes. V. Mouchlis, J. McCammon, E. Dennis. UC San Diego. (765.9) 5:15 Correlation of Fitness Landscapes from Three Orthologous TIM Barrels Originates from Sequence and Structure Constraints. Y.H. Chan, S.V. Venev, K.B. Zeldovich, C.R. Matthews. UMass Medical School. (761.27) 5:30 Allosteric Regulation and Enzymatic Mechanism of YopJ Family of Bacterial Effectors. J. Song, Z. Zhang, K. Ma, L. Gao, W. Ma. University of California at Riverside. (765.4)

425. LIPIDIC CUBIC PHASE CRYSTALLOGRAPHY Workshop (Sponsored by: JBC and LI-COR) Tue. 6:15 pm—McCormick Place Convention Center, W184BC Chaired: A. Kruse and A. Manjlik Lipidic cubic phase crystallography and related methods have transformed membrane-protein structural biology. They have led us to most of the known structures of G-protein-coupled receptors, as well as structures of many other membrane proteins, enzymes and transporters. This workshop will focus on how to crystallize membrane proteins by the lipidic cubic phase method and will include a live hands-on demonstration of the technique.

(Sponsored by: JBC and LI-COR)

Chaired: F.P. Guengerich and K. Sakabe Interested in publishing your research in the Journal of Biological Chemistry? Make sure you are presenting your research rigorously, clearly and compellingly! The JBC editors discuss important aspects authors need to consider when preparing their manuscripts for submission. Topics to be discussed include clarity of the text, including title and abstract, data presentation, database compliance, and transparency.

427. PRINCIPLES AND APPLICATIONS OF MODERN KINETIC AND EQUILIBRIUM ANALYSIS Workshop (Sponsored by: JBC and LI-COR) Tue. 6:15 pm—McCormick Place Convention Center, W186ABC Chaired: K. Johnson This workshop will teach attendees how to answer important questions about enzyme mechanisms by designing the right experiments and interpreting them quantitatively. It will present basic foundations and applications of kinetic analysis, then cover topics ranging from chemical kinetics and enzymology to pharmacokinetics and cell biology. It will demonstrate the use of KinTek computer simulation software to fit multiple data sets simultaneously, including kinetic and equilibrium measurements. Attendees will learn how to perform a wide range of experiments and interpret them rigorously, without simplifying approximations and errors inherent in fitting data using equations. The workshop will be taught by Kenneth Johnson at The University of Texas and founder of KinTek Corporation, a leader in precision stepped-flow and quench-flow instruments for rapid transient reaction kinetics.

428. ASBMB WOMEN SCIENTISTS MENTORING AND NETWORKING EVENT Special Event Tue. 7:30 pm—Hyatt Regency McCormick Place, Grant Park B Join us for lively conversation focusing on the importance of mentors and sponsors at the various stages of career development and factors that affect the success of mentoring relationships. ASBMB members and biochemistry attendees welcome.

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Nutrition 25. NUTRITIONAL SCIENCES COUNCIL BUSINESS MEETING AND BREAKFAST Forum (Sponsored by: Nutritional Sciences Council) Tues. 7:00 am—McCormick Place Convention Center, S105BCD Chaired: S. Adams

429. EXPLORING MEASUREMENT ERROR AND ITS IMPLICATIONS FOR DIET AND PHYSICAL ACTIVITY DATA Symposium Tue. 8:00 am—McCormick Place Convention Center, S100BC Chaired: A.F. Subar 8:00

8:25 8:50 9:15

9:40

A Comparison of Web-based Self-reported 24-hr Recalls, Food Frequency Questionnaires, and Food Records to Recovery Biomarkers. Yikyung Park. Washington Univ. in St. Louis, Sch. of Med. Measurement Error Structure of Dietary Self-reports in IDATA: Recalls, Records, and Questionnaires. Kevin Dodd. National Cancer Inst. Physical Activity Assessment: Working with What is Available and Anticipating the Future. Heather Bowles. National Cancer Inst. The Measurement Error Properties of Physical Activity Data Collection Instruments: Physical Activity Questionnaire, ACT24, Activity Monitors. Victor Kipnis. National Cancer Inst. Expanding the Study of Measurement Error in Diet and Physical Activity Measurement Instruments: The Multi-cohort Eating and Activity Study for the Understanding of Reporting Error (MEASURE). Amy Subar. National Cancer Inst.

430. IMPLEMENTATION RESEARCH IN NUTRITION: PURPOSES, METHODS AND APPLICATIONS Symposium Tue. 8:00 am—McCormick Place Convention Center, S100A Chaired: D. Pelletier and M. Arabi 8:00 8:20

Implementation Science: Frameworks, Applications and Critical Contributions to Advancing Global Public Health Nutrition. David Pelletier. Cornell Univ. Application of Implementation Science Framework and Embedded Implementation Research Within One Intervention Area: The Case of Infant and Young Child Nutrition (IYCN) Program. Lynnette Neufeld. Global Alliance for Improved Nutrition.

8:40 Advancing Implementation Science in Nutrition: Experiences from the NIH-PEPFAR PMTCT Implementation Science Alliance. Rachel Sturke. NIH Fogarty International Center.

431. CARDIOVASCULAR EFFECTS OF DIETARY BIOACTIVE COMPONENTS Oral Tue. 8:00 am—McCormick Place Convention Center, S102BC 8:00 431.1 The Impact of Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: An Acute Dose Response Study. E. Park, Y. Huang, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Illinois Institute of Technology, University of California at Davis. 8:15 431.2 Watermelon and L-Arginine Consumption Regulate Gene Expression Related to Serum Lipid Profile, Inflammation, and Oxidative Stress in Rats Fed an Atherogenic Diet. J. Beidler, S. Hooshmand, M. Kern, A. Figueroa, M. Hong. San Diego State University and Florida State University. 8:30 431.3 Daily Mango (Mangifera indica L.) Consumption for 42 Days Differentially Modulates Metabolism and Inflammation in Lean and Obese Individuals. C. Fang, H. Kim, R. Barnes, S.T. Talcott, S.U. Mertens-Talcott. Texas A&M University. 8:45 431.4 Raspberries Modulate Postprandial Glycemia and Markers of Lipid Oxidation and Inflammation in Type 2 Diabetes. J. Schell, N. Betts, A. Basu. Oklahoma State University. 9:00 431.5 Strawberry Supplementation Lessens Vascular Inflammation and Dysfunction Displayed by Diabetic db/db Mice. C. Petersen, D. Bharat, B. Cutler, S. Gholami, C. Denetso, J. Mueller, J. Cho, J. Kim, J. Symons, A. Pon Velayutham. University of Utah. 9:15 431.6 Mechanism of Neuroprotectin D1 Action After Hypoxic-Ischemic Injury in Neonatal Mice. H. Zirpoli, S. Sosunov, Z. Niatsetskaya, K. Mayurasakorn, D. Kollareth Manual, P. Norris, I. Reilly, Serhan, V. Ten, R. Deckelbaum. Columbia University Medical Center and Brigham and Women’s Hospital and Harvard Medical School. 9:30 431.7 Consumption of 2 Eggs Per Day as Compared to an Oatmeal Breakfast Increases Plasma Carotenoids and Markers Associated with Reverse Cholesterol Transport in Young, Healthy Individuals. A.C. Missimer, D.M. DiMarco, A. Murillo, C.L. Millar, C.N. Blesso, M. Fernandez. University of Connecticut. 9:45 431.8 Effect of Tocotrienol and Statin on Glucose Homeostasis in High-Fat-Diet-Induced Obese Mice. K. Wright, G. Kaur, M.D. Tomison, G. Ogunmokun, A. Rodriguez, J. Dufour, R. Quintana, C. Shen. Texas Tech University Health Sciences Center.

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432. NUTRITION EDUCATION AND BEHAVIOR IN SCHOOL-AGED CHILDREN Oral Tue. 8:00 am—McCormick Place Convention Center, S102D Chaired: R. Scherr and H. Muzaffar 8:00 432.1 Comparison of Common Threads Cooking and Nutrition Education Program in Elementary and Middle School Students. N.K. Edens, S. Folkens, S. Sharma, A. Wojtowicz. Common Threads. 8:15 432.2 Sustained Effects of an Intervention to Improve Willingness to Try New Foods on Preschoolers’ Liking Ratings of a Target Vegetable. K.J. Moding, L.L. Bellows, C. Palmer, S.L. Johnson. University of Colorado Anschutz Medical Campus and Colorado State University. 8:30 432.3 Providers’ Perceptions of Child Feeding and Activity Recommendations Related to Early Childhood Obesity Prevention. R. Heller, J. Chiero, N. Trout, A.R. Mobley. University of Connecticut and Connecticut Children’s Medical Center. 8:45 432.4 Agent-Based Modeling of Social Norm Impacts on Obesity and Eating Behaviors Among School Children in China and the United States. H. Xue, J. Zhang, F. Xu, Y. Wang. Ball State University, Gannon University, Nanjing Municipal Center for Disease Control and Prevention, People’s Republic of China. 9:00 432.5 Using Theory to Develop an Experiential Physical Activity Curriculum. D.S. Fetter, R.E. Scherr, J.D. Linnell, J.J. Bergman, M. Byrnes, M. Gerdes, L.D. Ruiz, S. Zidenberg-Cherr. University of California, Davis, Oregon State University Extension Service, Tillamook and Lincoln Counties, University of California CalFresh Nutrition Education Program and University of California Agriculture and Natural Resources. 9:15 432.6 The Association Between Socio-Demographic and Anthropometric Variables and Food Literacy Scores in Elementary School Children. S. Skeaff, L. Ware, N. Davis, D. Power, K. Russell, C. Cameron, M. Skeaff. University of Otago, New Zealand. 9:30 432.7 Do Child Eating Behaviors Moderate Relationships Between Food Parenting Practices and Child Food Preferences? R.L. Vollmer, J. Baietto. Bradley University and Illinois State University. 9:45 432.8 Evaluation of High School Students’ Intrinsic Motivation and Perceived Competence to Cook Using the Adolescent Motivation to Cook Questionnaire. D. Miketinas, M. Cater, A. Bailey, K. Rhea, G. Tuuri. Louisiana State University and Louisiana State University Agricultural Center.

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433. OBESITY DIAGNOSIS AND TREATMENT Oral Tue. 8:00 am—McCormick Place Convention Center, S103A Chaired: K. Balantekin and H. Nicastro 8:00 433.1 3D Imaging Technology for Human Body Size and Shape Analysis: Comparison of Three Different Acquisition Technologies. B. Bourgeois, D. Latimer, C.R. Stannard, L. Romeo, X. Li, J. Shepherd, B.K. Ng, S.B. Heymsfield. Pennington Biomedical Research Center, Louisiana State University, Louisiana State University, University of California at San Francisco. 8:15 433.2 Validity of Weight Screening Approaches to Proximate Body Composition in Service Members with Lower Limb Amputation. B. George, K. Lee, W. Song, A.L. Pruziner, A.A. Andrews. Michigan State University, Walter Reed National Military Medical Center and National Institute of Standards and Technology. 8:30 433.3 Determining the Accuracy and Reliability of Indirect Calorimeters Utilizing the Methanol Combustion Technique. S. Kaviani, D.A. Schoeller, E. Ravussin, E. Melanson, S.T. Henes, L.R. Dugas, R.E. Dechert, G.E. Mitri, P.F. Schoffelen, P. Gubbels, A. Tornberg, S. Fritzdorf, M. Akkermans, J.A. Cooper. University of Georgia, University of Wisconsin-Madison, Pennington Biomedical Research Center, University of Colorado Anschutz Medical Campus, Georgia State University, Loyola University Chicago, University of Michigan Health System, Maastricht Univeristy Medical Centre, Netherlands, Topsport Expertise & Innovation Centre, Netherlands, Lund Univerisity, Sweden and Center of Expertise for Chronic Organ Failure, Netherlands. 8:45 433.4 Food Addiction and Dietary Intake in Morbidly Obese Females Before and After Vertical Sleeve Gastrectomy. A. Kim, C. Moore, V. Sherman, N. Tariq, M. Maziarz. Texas Woman’s University and Houston Methodist Hospital. 9:00 433.5 Dietary Fiber Supplementation Normalizes Serum Metabolites of Adults with Overweight/obesity in a 12Week Randomized Control Trial. S. Mayengbam, J.E. Lambert, J.A. Parnell, J.M. Tunnicliffe, J. Han, T. Sturzenegger, H.J. Vogel, J. Shearer, R.A. Reimer. University of Calgary, Canada, Mount Royal University, Canada, Alberta Agriculture and Rural Development, Canada, Cumming School of Medicine and University of Calgary, Canada. 9:15 433.6 The Impact of Avocado Fruit on Postprandial Satiety: An Acute Dose Response Study. Y. Huang, E. Park, D. Xiao, I. Edirisinghe, B.M. Burton-Freeman. Institute for Food Safety and Health, Illinois Institute of Technology, University of California at Davis. 9:30 433.7 High Vitamin D Intake Improves Bone Health in Obesity. I.N. Sergeev. South Dakota State University. 9:45 433.8 What Monitoring Strategies Are Most Successful for Promoting Weight Loss? M.R. Jospe, M. Roy, R.C. Brown, S.M. Williams, H.R. Osborne, K.A. MeredithJones, J.R. McArthur, E.E. Fleming, R.W. Taylor. University of Otago, New Zealand.

TUESDAY NUTRITION

434. NUTRITIONAL IMMUNOLOGY AND INFLAMMATION Oral Tue. 8:00 am—McCormick Place Convention Center, S103BC Chaired: S.S. Comstock and E. Ananieva 8:00 434.1 Obesity Resets the Metabolic Profile of T Cells, Resulting in Reduced Memory T Cell Responses to Influenza Infection. J. Rebeles. UNC Chapel Hill. 8:15 434.2 Soluble Dietary Fiber in Obesity-Associated Inflammation and Oxidative Stress in African American Women. S.A. Nance, A.V. Duncan, T.M. Gwathmey, K.G. Hairston. Wake Forest University School of Medicine. 8:30 434.3 Altered Metabolism and Function of T Cells Isolated from Influenza Vaccinated Obese Adults. W.D. Green, J. Rebeles, T.J. Noah, M.G. Hudgens, S.S. Weir, N.J. MacIver, M.A. Beck. University of North Carolina at Chapel Hill and Duke University. 8:45 434.4 Impact of Maternal Obesity and High Fat Diet During Pregnancy and Lactation on Offspring Body Weight, Immune Function, and Resistance to Influenza Infection. W. Guo, D. Wu, L. Li, D.E. Smith, S.N. Meydani. JM USDA Human Nutrition Research Center on Aging at Tufts University. 9:00 434.5 Transcriptome Analysis Reveals Persistent Effects of Neonatal Diet on Small Intestine Gene Expression Profile in a Porcine Model. M.K. Saraf, A.K. Bowlin, C. Chen, H. Dawson, T.M. Badger, V. Yeruva. Arkansas Children’s Nutrition Center, UAMS, USDA-ARS Human Nutrition Research Center and ACRI. 9:15 434.6 Human Breast Milk Feeding Induces Stronger Humoral Immune Response Than Formula Feeding in Neonatal Porcine Model. V. Yeruva, M.K. Saraf, A.K. Bowlin, T.M. Badger. Arkansas Children’s Nutrition Center. 9:30 434.7 Supplemental Protein and Multi-Nutrient Beverage Improve Immune Response at Experimental Wound Site During 72-h Sleep Restriction. T.J. Smith, M.A. Wilson, A.J. Young, S.J. Montain. U.S. Army Research Institute of Environmental Medicine. 9:45 434.8 Myeloid Derived Suppressor Cells (MDSC) Are Vitamin D Targets and 1α, 25 Dihydroxyvitamin D (1,25(OH)2d) Inhibits Their Ability to Suppress T Cell Function. R.D. Calvert, G.N. Burcham, T.L. Ratliff, J.C. Fleet. Purdue University and Southern Indiana Purdue Agricultural Center.

435. DIET AND CANCER: ANIMAL STUDIES AND BIOMARKERS Oral Tue. 8:00 am—McCormick Place Convention Center, S103D Chaired: L. Yan and Z. Liu 8:00 435.1 Nobiletin and Its Colonic Metabolites Suppress Colitis-Associated Colon Carcinogenesis by Downregulating iNOS, Inducing Anti-Oxidative Enzymes and Arresting Cell Cycle Progression. X. Wu, M. Song, Z. Gao, M. Wang, F. Li, J. Zheng, H. Xiao. University of Massachusetts Amherst, Chinese Academy of Agricultural Sciences, People’s Republic of China.

8:15 435.2 Parabacteroides distasonis Attenuates Colonic Inflammation and Prevents Tumor Formation in AzoxymethaneTreated High-Fat Diet-Fed Mice. G. Koh, A.V. Kane, K. Lee, Q. Xu, X. Wu, J.B. Mason, J.W. Crott. USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Tufts Medical Center and Tufts University. 8:30 435.3 Consumption of the Total Western Diet (TWD) Enhanced and Sustained Colonic Inflammation and Promoted Colon Tumorigenesis in Mice, Which Led to Marked Changes in the Composition of the Gut Microbiome in Mice. A. Benninghoff, A. Hunter, S. Monsanto, S. Phatak, K. Hintze, R. Ward, M. Lefevre. Utah State University. 8:45 435.4 Ancestral and Multi-Generational Consumption of the Total Western Diet in Mice Promotes Colitis-Associated Colorectal Cancer in Third-Generation Offspring. S. Phatak, D. Larson, A. Hunter, C. Neal, K. Contreras, K. Pontsler, T. Armbrust, D. Rodriguez, B. Abercrombie, K. Hintze, R. Ward, A. Benninghoff. Utah State University. 9:00 435.5 Aberrant Crypt Formation Accompanies an Increase of Opportunistic Pathogens/bacteria in the Inflammatory Gut of C57BL/6 Mice Fed a High-Fat Diet. H. Zeng, S.L. Ishaq, Z. Liu, K.A. Keehr, M.R. Bukowski. Grand Forks Human Nutrition Research Center, Montana State University and University of Massachusetts. 9:15 435.6 Changes in Body Adiposity and Its Associated Inflammation Affect Metastasis of Lewis Lung Carcinoma in Mice. L. Yan, S. Sundaram. USDA ARS Grand Forks Human Nutrition Research Center. 9:30 435.7 The Influence of Genetic Ablation of Tumor Necrosis Factor-α on the Colonic Wnt Pathway Cascade Under an Obese State. Z. Liu, J. Li, A.M. Frederick, Y. Jin, X. Xu, R.J. Wood. University of Massachusetts, Amherst, Tufts University, Shengjing Hospital of China Medical University, People’s Republic of China. 9:45 435.8 Green Tea Extract Protects Against Diethylnitrosamine-Mediated Liver Injury and Cell Proliferation by Attenuating STAT3 and iNOS Expression in High Fat-Induced Obese Mice with Nonalcoholic Steatohepatitis. J.B. Kim, J. Li, C. Chitchumroonchokchai, G.Y. Sasaki, J.M. ThomasAhner, S.K. Clinton, R.S. Bruno. The Ohio State University.

436. VITAMINS AND CHRONIC DISEASE AND MICRONUTRIENT INTERVENTIONS Oral Tue. 8:00 am—McCormick Place Convention Center, S104A 8:00 436.1 Vitamin D Derived from Dietary Whole Egg Is More Effective Than Supplemental Vitamin D3 in Maintaining Vitamin D Balance in Type 2 Diabetic Rats. C.J. Saande, C.H. Reed, C.A. Coonts, K.E. Hahn, M.J. Rowling, K.L. Schalinske. Iowa State University. 8:15 436.2 Whole Egg Consumption as a Dietary Prevention and Treatment Intervention Increases Serum 25-Hydroxyvitamin D Concentrations in Rats with DSS-Induced Colitis. S.K. Jones, C.H. Reed, K.E. Hahn, C.A. Coonts, D.M. Worrall, M.J. Rowling, K.L. Schalinske. Iowa State University. 8:30 436.3 Role of Intracellular Calcium in Vitamin D-Treated L6 Myoblast Differentiation and Fiber Type Specification. M. Park, J. Kim, K. Whang. Korea University, Republic of Korea.

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NUTRITION TUESDAY 8:45 436.4 1,25-Dihydroxyvitamin D3 Mediates L6 Myoblast Differentiation via Vitamin D Receptor (VDR). M. Park, J. Kim, K. Whang. Korea University, Republic of Korea. 9:00 436.5 A Novel, High Precision Multiple-Meal Stable Isotope Method to Compare Iron Absorption from Extruded FePP-Fortified Rice Containing Different Zinc Compounds, Citric Acid/Trisodium Citrate and EDTA in Ghanaian Children. L. Hackl, A. Abizari, H. Zungbey-Garti, C. Zeder, C. Speich, C.I. Cercamondi, M.B. Zimmermann, D. Moretti. Swiss Federal Institute of Technology, Switzerland, University for Development Studies, Ghana. 9:15 436.6 Home Fortification with Multiple Micronutrient Powders Improves Infant and Young Child Development in Bihar, India. L. Larson, M. Young, P. Bauer, M. Rukshan, A. Webb Girard, U. Ramakrishnan, P. Verma, I. Chaudhuri, S. Srikantiah, R. Martorell. Emory University and CARE India, India. 9:30 436.7 early-Life Iron Supplementation Alters Whole Body Iron Homeostasis, Serum Metabolites, and Social Novelty Discrimination in Pre-Weanling Pigs. P. Ji, S. McClorry, B. Lonnerdal, C. Slupsky, K. Kim, C.N. Jinno. University of California at Davis. 9:45 436.8 Increases in Indicators of Iron, Zinc, Folate and Vitamin B12 Status in Urban Cameroon Following Wheat Flour Fortification. R. Engle-Stone, M. Nankap, A.O. Ndjebayi, L.H. Allen, S. Shahab-Ferdows, D. Hampel, D.W. Killilea, M. Gimou, L.A. Houghton, A. Friedman, A. Tarini, R. Stamm, K.H. Brown. University of California, Helen Keller International, USDA, ARS Western Human Nutrition Research Center, Children’s Hospital Oakland Research Institute, Centre Pasteur, Cameroon, University of Otago, New Zealand and Bill & Melinda Gates Foundation.

437. TRANSLATION OF NUTRITION SCIENCE AND FOOD SCIENCE AND TECHNOLOGY IN NUTRITION Oral Tue. 8:00 am—McCormick Place Convention Center, S104B

9:00 437.5 Verifying Fibers Meet Regulatory Definitions for Nutrition Facts Labeling: A Randomized, Controlled Trial Evaluating Polydextrose in Dry Form. A. Zhao, S. Rahman, E. Park, D. Xiao, I. Edirisinghe, B.B. Freeman. Illinois Institute of Technology. 9:15 437.6 Foodomics Application: Analysis of Dietary Components of the DASH Diet Pre and Post Consumption. Y. Nkrumah-Elie, R. Reisdorph, B. Tooker, M. Tang, L. O’Connor, S. Borengasser, R. Sayer, N. Krebs, W. Campbell, N. Reisdorph. University of Colorado, Anschutz Medical Campus and Purdue University. 9:30 437.7 Health Modifying Regions in the Oat (Avena sativa) Genome Responsible for Beneficial Effects on Immune and Gastrointestinal Health. W.W. Bussler, K. Dezego, M. Bowen, A. Buige, D. Esposito, M. Lila, S. Komarnytsky. Plants for Human Health Institute, North Carolina State University, North Carolina State University, Catawba College and University of North Carolina at Chapel Hill. 9:45 437.8 Differences Between Organic and Conventionally Produced Milk Reduce When Both Systems Use Pasture-Feeding. B.H. Schwendel, T.J. Wester, P.C. Morel, B. Fong, M.H. Tavendale, C. Deadman, N.M. Shadbolt, D.E. Otter. AgResearch Grasslands, New Zealand, Massey University, New Zealand, Fonterra, New Zealand and University of Wisconsin-Madison.

438. HISTORY OF NUTRITION FORUM: HISTORY OF THE DIETARY GUIDELINES FOR AMERICANS Forum Tue. 8:00 am—McCormick Place Convention Center, S105A Chaired: L. Jahns and F. Nielsen 8:00 8:25 8:50

Chaired: N. Khan and E. Radlowski 8:00 437.1 Awareness of Dietary Guidance and Diet Quality of Adults, What We Eat in America, NHANES 2007– 2012. K. Hoy, J.D. Goldman, A.J. Moshfegh. ARS-USDA. 8:15 437.2 Is the Consumption of Foods Passing Reformulation Standards Associated with the HEI-2010? G. Masset, F. Mainardi, M. Gressier. Nestlé Research Center, Switzerland and Nestlé Institute of Health Science, Switzerland. 8:30 437.3 Setting Reformulation Targets per Serving: A Global System for Sodium and Sugar Reduction and Its Applicability in the USA. A. Vlassopoulos, M. Gressier, G. Masset. Nestle Research Center, Switzerland. 8:45 437.4 Modeled Impact of Food and Beverage Reformulations on Added Sugars Intake and Its Social Gradient in the US. M. Gressier, K.C. Mathias, A. Drewnowski, A. Vlassopoulos, G. Masset. Nestlé Research Center, Switzerland and University of Washington.

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History of Federal Dietary Recommendations Prior to the Dietary Guidelines for Americans—1894–1970s. Wendy Davis. USDA ARS. Evolution of Dietary Guidelines for Americans, 1980 to 2015. Alice Lichtenstein. Tufts Univ. Challenges and Controversial issues in the Dietary Guidelines for Americans, 1980 to 2015. Marion Nestle. New York Univ. Who Uses Them, and How: Past Accomplishments and Future Methods for Reaching Targeted Audiences. Suzanne Murphy. Univ. of Hawaii at Manoa Cancer Ctr.

440. AFRICAN NUTRITION GRADUATE STUDENTS NETWORK FORUM Forum Tue. 9:00 am—McCormick Place Convention Center, S105BC Chaired: J. Ashong

TUESDAY NUTRITION

441. DIET AND EXERCISE-INDUCED EPIGENETIC ALTERATIONS OF SKELETAL MUSCLE AND WHITE, BEIGE, AND BROWN ADIPOCYTES

443. PROTEIN INTAKE AND HEALTH Oral

Symposium

Tue. 10:30 am—McCormick Place Convention Center, S102BC

(Supported by USDA Agriculture Research Service)

Chaired: J. Carbone and L. Margolis

(Sponsored by: Nutrient Gene Interactions RIS) Tue. 10:30 am—McCormick Place Convention Center, S100BC Chaired: K.J. Claycombe-Larson 10:30

Introduction and Overview. James Roemmich. USDA ARS Grand Forks Human Nutrition Research Ctr. 10:40 Control of Chromatin Architecture and Brown Fat Transcriptional Programming. Suzi Shapira. 11:05 Influence of Maternal Exercise on Offspring Skeletal Muscle and Adipose Tissue Metabolic Health and Adiposity. Kevin Pearson. Univ. of Kentucky. 11:30 Transcriptional and Epigenetic Regulation of Beige Adipocyte Epigenetic Factors by Metabolites. Shingo Kajimura. Univ. of California, San Francisco. 11:55 Maternal Under- or Over-Nutrition and Offspring Exercise Effects on Subcutaneous Adipose Tissue Programming and Obesity. Kate ClaycombeLarson. USDA ARS Grand Forks Human Nutrition Research Ctr.

442. FOOD AND NUTRITION BOARD FORUM: ASSESSING OBESITY TRENDS, MEETING THE NUTRITIONAL NEEDS OF WIC PARTICIPANTS, AND UNDERSTANDING FOOD ALLERGY: FOCUS ON CHILDREN Forum Tue. 10:30 am—McCormick Place Convention Center, S100A Chaired: A.L. Yaktine and C. Garza 10:30 Food and Nutrition Board Update. Cutberto Garza. Boston Col. 10:45 Assessing Prevalence and Trends in Obesity: Navigating the Evidence. Cheryl Anderson. Univ. of California San Diego Sch. of Med. 11:15 Updating the WIC Food Packages: Alignment with the 2015 Dietary Guidelines. Kathleen Rasmussen. Cornell Univ. 11:45 Food Allergy: A Roadmap to Safety. Virginia Stallings. Univ. of Pennsylvania.

10:30 443.1 A Pilot Study Assessing Whether the Consumption of a Protein-Rich Breakfast Improves Appetite Control, Eating Behavior, and Sleep Quality Compared to Skipping Breakfast in Healthy Young Professionals. J.A. Gwin, H.J. Leidy. Purdue University. 10:45 443.2 Even Mealtime Distribution of Protein Intake Is Associated with Greater Muscle Strength, but Not with 3-Year Decline, in Free-Living Older Adults: The Nuage Study. S. Farsijani, H. Payette, J.A. Morais, B. Shatenstein, P. Gaudreau, S. Chevalier. McGill University, Canada, University of Sherbrooke, Canada and University of Montreal, Canada. 11:00 443.3 Protein Intake in Early Childhood Is Not Associated with Adiposity, Height, or IGF-I in Mid-Childhood Among Well-Nourished Children in a U.S. Cohort. K. Switkowski, P. Jacques, A. Must, E. Oken. Harvard Medical School and Harvard Pilgrim Health Care Institute, Friedman School of Nutrition Science and Policy, Tufts University, Jean Mayer—USDA Human Nutrition Research Center on Aging, Tufts University, School of Medicine, Tufts University and Harvard School of Public Health. 11:15 443.4 Beneficial Effects of Animal and Plant Proteins on Skeletal Muscle Mass and Functional Status. L.L. Moore, M. Bradlee, M.R. Singer. Boston University School of Medicine. 11:30 443.5 Effects of Consuming Protein-Rich Supplements Between or with Meals on Changes in Body Composition with Resistance Training: A Systematic Review of Randomized Controlled Trials. J.L. Hudson, R.E. Bergia, W.W. Campbell. Purdue University. 11:45 443.6 Effects of Dietary Protein Evenly Spread Throughout the Day on Sleep and Mood in Overweight Women During Sub-Chronic Energy Balance and Energy Restriction. J.A. Gwin, H.J. Leidy. Purdue University. 12:00 443.7 Effects of Dietary Protein Source and Amount on Bone Quantity and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model of Postmenopausal Obesity. C.S. Wright, R.P. Main, W.W. Campbell. Purdue University. 12:15 443.8 Effects of a High Protein Diet with and Without a Multi-Strain Probiotic and Prebiotic on Microbiota and Gastrointestinal Wellness in Older Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. A.L. Ford, C. MacPherson, S. Girard, T.A. Tompkins, J. Tremblay, M. Christman, W.J. Dahl. University of Florida, Lallemand Health Solutions, Canada, National Research Council Canada, Canada and MCC Statistical Consulting LLC.

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444. NUTRITIONAL IMPACTS TO MICROBIOME FUNCTION Oral Tue. 10:30 am—McCormick Place Convention Center, S102D Chaired: D.A. Sela 10:30 Introduction. 10:45 444.1 Early Diet Has Differential Effects on the Small Intestine Microbiome by Region in Neonatal Piglets. B. Piccolo, A. Bowlin, M. Saraf, K. Mercer, S. Bhattacharya, S. Chintapalli, S. Adams, K. Shankar, T. Badger, L. Yeruva. Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. 11:00 444.2 Interactive Effects of Blueberry Supplementation and GPR109A Deletion on Gut Microbiome Profiles in Mice. K. Shankar, Z. Ying, L.P. Oksana, S.V. Chintapalli, J. Chen, U.D. Wankhade. University of Arkansas Medical Sciences and Arkansas Children Nutrition Center. 11:15 444.3 Prebiotics and Milk Oligosaccharides Affect Colonic Metabolome and Stressor-Induced Immunomodulation in Mice. M.T. Bailey, R.M. Jaggers, A.R. Mackos, M. Chichlowski, B. Berg. Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Mead Johnson Pediatric Nutrition Institute. 11:30 444.4 Prebiotic Enhancement of Intestinal Adaptation in Piglets with Short Bowel Syndrome Is Associated with Microbial and Enteroendocrine Modifications. B.R. Loman, K.A. Tappenden. University of Illinois Urbana-Champaign. 11:45 444.5 High Energy Expenditure and Negative Energy Balance Modulate Composition and Metabolism of the Gut Microbiota. J. Karl, L.M. Margolis, N.E. Murphy, S. Martini, Y. Gundersen, J.W. Castellani, C.T. Carrigan, H.K. Teien, E.H. Madsilen, N. Chakraborty, R. Kumar, A. Hoke, A. Gautam, R. Hammamieh, S.J. Montain, S.M. Pasiakos. US Army Research Institute of Environmental Medicine, Norwegian Defense Research Establishment, Norway, Geneva Foundation, Frederick National Laboratory for Cancer Research and US Army Center for Environmental Health Research. 12:00 444.6 Effects of the Food Matrix and Western Diet on the Mouse Microbiome. K. Hintze, T. Hisatome, S. Kellen, A. Hunter, N. Aardema, R. Ward, A. Benninghoff, M. Lefevre. Utah State University. 12:15 444.7 Effects of Storage Conditions on Gut Microbiota Data. K.Y. Sugino, S.S. Comstock. Michigan State University.

445. HEALTH DISPARITIES AND PROMOTING HEALTH IN DIVERSE POPULATIONS Oral Tue. 10:30 am—McCormick Place Convention Center, S103A Chaired: S. Colby and M.D. Teran-Garcia 10:30 445.1 Nutrient Inadequacy Among Nutritionally Vulnerable Populations in the Us. Z. Conrad, L.K. Johnson, W. Juan, J.N. Roemmich, L. Jahns. US Department of Agriculture, Agricultural Research Service, US Department of Health and Human Services and Food and Drug Administration.

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10:45 445.2 Association of Supplemental Nutrition Assistance Program Participation with Social Cohesion and Financial Worry Based on Race and Ethnicity Among U.S. Adults. M.P. Burke, E.A. Frongillo. U.S. Department of Agriculture and University of South Carolina. 11:00 445.3 Longitudinal Change in the Diet’s Monetary Value Is Associated with Its Change in Quality and Micronutrient Adequacy Among Urban Adults. M.A. Beydoun, M.T. Fanelli-Kuczmarski, J.M. Poti, A. Allen, H.A. Beydoun, M.K. Evans, A.B. Zonderman. National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, University of Delaware, University of North Carolina at Chapel Hill, Centers for Medicare and Medicaid Services (CMS), Johns Hopkins Medical Institution and Johns Hopkins University. 11:15 445.4 Extension-Delivered Diabetes Program for Rural-Residing Latinos Improves Diabetes Self-Management, Self-Efficacy and Knowledge. S.L. Francis, M. Keane. Iowa State University. 11:30 445.5 Association Between Emotional Eating and Overeating in Latinos. A.A. Lopez-Cepero, C. Frisard, S. Lemon, M. Rosal. University of Massachusetts Medical School. 11:45 445.6 A Race-Specific Interaction Between Vitamin K Status and Statin Use During Warfarin Therapy Initiation. J.M. Kelly, S.G. Harshman, C.M. Brensinger, K. Barger, S.E. Kimmel, S.L. Booth. JM USDA HNRCA Tufts University and University of Pennsylvania. 12:00 445.7 Feeding Practices and Lifestyle Changes After Migration: Perceptions of First Generation Latinas Living in an Emerging Community. M. Pineros-Leano, K. Tabb, Y. Castaneda, J.M. Liechty. University of Illinois at Urbana-Champaign. 12:15 445.8 High Prevalence of Asthma and Its Determinants Among Hispanic/Latino Children Enrolled in Michigan Migrant and Seasonal Head Start Programs. N. Farabi, S. Song, E.T. Crockett, W.O. Song. Michigan State University.

446. EPIDEMIOLOGICAL RESEARCH ADDRESSING DIET AND HEALTH OUTCOMES Oral Tue. 10:30 am—McCormick Place Convention Center, S103BC Chaired: K.M. Mangano and S. Noel 10:30 446.1 Dietary Patterns and Risk of Pancreatic Cancer: A Systematic Review. J. Zheng, M. Guinter, A. Merchant, M. Wirth, J. Zhang, R. Stolzenberg-Solomon, S. Steck. University of South Carolina and National Cancer Institute. 10:45 446.2 Evidence Mapping of Whole Grain Intervention Studies, Health Outcomes, and Reporting Practices. C.M. Sawicki, K.A. Livingston, P.F. Jacques, K. Koecher, N.M. McKeown. Tufts University, Bell Institute of Health and Nutrition and General Mills Inc. 11:00 446.3 Adherence to Sugar-Sweetened Beverages Recommendations Among Mexican Adults with Self-Reported Type 2 Diabetes. T.C. Aburto Soto, J.M. Poti, M.A. Mendez, B.M. Popkin. UNC. 11:15 446.4 Total Fluid Intake, Water and Sweet Beverages Intake: From a Median Intake to Identifying the Proportion of Individuals Potential at Risk. I. Guelinckx, M. Vecchio, E.T. Perrier, C. Morin. Danone Research, France.

TUESDAY NUTRITION 11:30 446.5 Leading Food Sources of Sodium in a Diverse Sample of Adults from Three US Metropolitan Areas. K.C. Hootman, L.M. Steffen, M.E. Cogswell, J.M. Shikany, C.D. Gardner, L.J. Harnack. University of Minnesota, Centers for Disease Control and Prevention, University of Alabama and Stanford University. 11:45 446.6 Low Sodium Intakes Are Not Associated with Lower Blood Pressure Levels Among Framingham Offspring Study Adults. L.L. Moore, M.R. Singer, M L. Bradlee. Boston University School of Medicine. 12:00 446.7 Dairy Products and Iodine-Containing Supplements Use Are Positively Associated with Iodine Status in Childbearing Age Women in the United States. M.A. Arsenault, K. Lee, W. Song. Michigan State University. 12:15 446.8 Increased Yogurt Intake Lowers Risk of Cardiovascular Disease Among Middle-Aged Adults with High Blood Pressure. J.R. Buendia, Y. Li, F.B. Hu, M. Bradlee, P.A. Quatromoni, H.J. Cabral, M.R. Singer, L.L. Moore. Boston University School of Medicine, Harvard T.H. Chan School of Public Health, Sargent College of Health and Rehabilitation Sciences, Boston University and Boston University School of Public Health.

447. NUTRITION AND CARDIOMETABOLIC HEALTH

11:45 447.6 A Traditional Korean Diet Reduced Total Blood Cholesterol and Increased Telomere Length of Peripheral Blood Cells in Perimenopausal Korean Women. P. Shin, M. Kim, H. Lee, S. Park, D. Kwon, S. Choi. CHA University, Republic of Korea, Korea Food Research Institute, Republic of Korea, Gachon University, Republic of Korea, Chaum Life Center CHA University, Republic of Korea. 12:00 447.7 Lead Exposure, Dietary Magnesium and Glucose Homeostasis in Chinese Adults. M.A. Mendez, L. Liu, S. Du, H. Wang. University of North Carolina at Chapel Hill, Beijing Municipal Center for Disease Prevention and Control, People’s Republic of China, National Institute for Nutrition and Health, and Chinese Center for Disease Control and Prevention, People’s Republic of China. 12:15 447.8 Substitution of Carbohydrate with Whole Eggs or Egg Whites Attenuates Postprandial HyperglycemiaMediated Impairments in Vascular Endothelial Function in Prediabetic Men by Limiting Lipid Peroxidation and Dysregulated Arginine Metabolism. J.D. McDonald, C. Chitchumroonchokchai, J. Li, J.S. Volek, K.D. Ballard, R.S. Bruno. The Ohio State University and Miami University.

448. MAMMARY GLAND FUNCTION AND EFFECTS OF MILK COMPONENTS ON INFANT HEALTH

Oral

Oral

Tue. 10:30 am—McCormick Place Convention Center, S103D

Maternal, Perinatal and Pediatric Nutrition RIS

Chaired: A. Basu and S.A. Johnson 10:30 447.1 A Year-Long Trial to Examine the Effects of a Daily Dose of Walnuts on Cardiometabolic Risk Markers in an Elderly Population. A. Al Abdrabalnabi, E. Bitok, S. Rajaram, N. Rizzo, J. Sabaté. Loma Linda University. 10:45 447.2 Adopting, Abandoning, and Re-Adopting Healthy Eating Patterns Sends Cardiovascular Disease Risk Factors on a Rollercoaster Ride. W.W. Campbell, L.E. O’Connor, J. Li, R.D. Sayer, A.J. Wright. Purdue University. 11:00 447.3 Consumption of Up to Three Eggs Per Day Increases Dietary Cholesterol and Choline While Plasma LDL Cholesterol and Trimethylamine N-Oxide Concentrations Are Not Increased in a Young, Healthy Population. B.S. Lemos, D.M. DiMarco, A. Missimer, A.G. Murillo, O.V. Malysheva, M.A. Caudill, C.N. Blesso, M.L. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and Cornell University. 11:15 447.4 A Low Magnesium Diet Worsens Metabolic Disturbances and Insulin Sensitivity in Diabetic Mice. A.J. Smith, J. Challburg, A.L. O’Farrell, B. Duke, J.D. Symons, T. Jalili. University of Utah. 11:30 447.5 A 12-Week Randomised Controlled Trial to Evaluate Effects of Dietary Pulse Consumption on Cardiovascular Disease Risk Factors. A.M. Hill, P. Zahradka, A.M. Coates, P.R. Howe, C.G. Taylor, J.D. Buckley. University of South Australia, Australia, Canadian Centre for Agri-Food Research in Health and Medicine, Canada, University of Manitoba, Canada and University of Newcastle, Australia.

Tue. 10:30 am—McCormick Place Convention Center, S104A Chaired: C-E. Briere 10:30 448.1 The Role of Milk Fat Globule Membranes in Behavior and Cognitive Function Using a Suckling Rat Pup Supplementation Model. L.R. Brink, B. Lonnerdal. University of California at Davis. 10:45 448.2 Human Milk Oligosaccharides and Food Sensitization at 12 Months in the CHILD Cohort. M.B. Azad, B. Robertson, A.K. Sharma, P. Subbarao, A.B. Becker, P.J. Mandhane, S.E. Turvey, D.L. Lefebvre, M.R. Sears, L. Bode. University of Manitoba, Canada, Children’s Hospital Research Institute of Manitoba, Canada, University of California San Diego, George & Fay Yee Centre for Healthcare Innovation, Canada, University of Toronto, Canada, University of Alberta, Canada, University of British Columbia, Canada and McMaster University, Canada. 11:00 448.3 Dietary Sialyllactose Influences Magnetic Resonance Imaging Outcomes in the Piglet Corpus Callosum. A.T. Mudd, S.A. Fleming, M. Chichlowski, B.M. Berg, S.M. Donovan, R.N. Dilger. University of Illinois and Mead Johnson Pediatric Nutrition Institute. 11:15 448.4 ZnT2 Regulates Lysosomal Acidification and Biogenesis During Mammary Gland Involution. O.C. Rivera, S.R. Hennigar, S. Lee, S.L. Kelleher. Pennsylvania State University Hershey College of Medicine and Pennsylvania State University. 11:30 448.5 A Combination of Milk Fat Globule Membrane and Prebiotics Modulates Pain Hypersensitivity and Cognitive Responses to Maternal Separation Stress. R.V. Waworuntu, K.M. Neufeld, S.M. O’Mahony, M. Pusceddu, B.M. Berg, T.G. Dinan, J.F. Cryan. Mead Johnson Pediatric Nutrition Institute, APC Microbiome Institute, Ireland and University College Cork, Ireland.

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NUTRITION TUESDAY 11:45 448.6 In Vitro Supplementation of Leucine Increases Murine HC11 Cell Proliferation. M.M. McGuckin, A. Suryawan, T.A. Davis, D.G. Peterson, R. Manjarin. California Polytechnic State University and Baylor College of Medicine. 12:00 448.7 Longitudinal Study of Pesticide Residue Levels in Human Milk from Western Australia During 12-Months of Lactation: Exposure Assessment for Infants. D.T. Geddes, J. Du, M.C. Gay, Z. Gridneva, C. Lai, P.E. Hartmann, R.D. Trengove. The University of Western Australia, Australia, Murdoch University, Australia and Metabolomics Australia, Australia. 12:15 448.8 Maternal High Fat Diet Significantly Impacts Milk miRNA and mRNA Content of Lactating Mice. Y. Chen, S. Yang, J. Crodian, S. Kuang, J. Wang, M. Gribskov, K. Plaut, T.M. Casey. Purdue University and [email protected]

452. W.O. ATWATER LECTURE Award Lecture (Sponsored by: USDA Agricultural Research Service) Tue. 1:00 pm—McCormick Place Convention Center, S100BC 1:00 Introduction. 1:05 Traveling the Road from Precision to Imprecision: Have I Gone in the Wrong Direction? Dennis Bier. USDA ARS Children’s Nutrition Research Ctr.

453. THE INTEGRATIVE PHYSIOLOGY OF A MEAL Symposium

449. HOW TO ACCESS AND USE A FIBER AND HEALTH OUTCOMES DATABASE FOR RESEARCHERS AND POLICYMAKERS Symposium (Supported by: ILSI North America) Tue. 11:00 am—McCormick Place Convention Center, S105A Chaired: N. McKeown and B. Lyle 11:15

Development of a Database on “Diet-Related Fibers and Human Health Outcomes” from 1946–2016. Kara Livingston. Tufts Univ. 11:45 Application of the “Diet-Related Fibers and Human Health Outcomes” database using Evidence Mapping Methodology. Caleigh Sawicki. Tufts Univ.

450. UNRAVELING THE COMPLEXITIES OF FOOD ALLERGY: IMPLICATIONS TO THE NUTRITIONIST, CONSUMER, AND FOOD INDUSTRY ASN Satellite (Supported by Egg Nutrition Center and the National Dairy Council) Tue. 12:45 pm—McCormick Place Convention Center, S105BCD Chaired: T. Rains and J. Nicholls 12:45 Introduction. Tia Rains. Egg Nutrition Ctr. 12:45 Introduction. Jill Nicholls. National Dairy Council. 1:00 TBD. Daniel Rotrosen. National Inst. of Allergy and Infectious Disease. 1:30 TBD. Steve Taylor. Univ. of Nebraska, Lincoln. 2:00 TBD. Virginia Stallings. Univ. of Pennsylvania.

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Tue. 3:00 pm—McCormick Place Convention Center, S100BC 3:00

Post-Meal Neurobiology. Christoph Buettner. Mt. Sinai Med. Ctr. 3:35 Post-Meal Endocrinology and GI Tract Physiology. Victoria Salem. Imperial Col. London. 4:10 Post-Meal Bioenergetics and Fuel Metabolism. Elizabeth Parks. Univ. of Missouri. 4:45 Post-Meal Hemodynamics, Platelet Reactivity and Inflammation. John Rutledge. Univ. of California, Davis.

454. DIETARY BIOACTIVE COMPONONENTS OF MEDICINAL, FUNCTIONAL AND FERMENTED FOODS Oral Tue. 3:00 pm—McCormick Place Convention Center, S102BC Chaired: A. Neilson 3:00 454.1 Beneficial Effects of Fermentation of Whole Grains (WG) and Whole Grain Resistant Starch (RS) in Lean Zucker Diabetic Fatty (ZDF) Rats. J. Guice, R. Page, D. Carvajal-Aldaz, A. Raggio, D. Obanda, H. Durham, M. Marco, G. Tuuri, R. Martin, B. Marx, D. Coulon, M. Keenan. LSU AgCenter, Facultad Ciencias de la Vida, Ecuador, University of California at Davis and LSU A&M. 3:15 454.2 Immunological Effects of Lactobacillus johnsonii N6.2 in Healthy Adults: A Double-Blind, Randomized Trial. G.L. Lorca, G. Marcial, A. Ford, S. Gezan, D. Perry, M. Haller, C. Wasserfall, T. Brusko, M. Atkinson, C. Gonzalez, W. Dahl. University of Florida. 3:30 454.3 Small Servings of Vegetables or a Cruciferous Supplement Do Not Affect Urinary Estrogen Metabolites in Premenopausal Women. S. Mondloch, C. Muir, S. Arscott, N. Binkley, S.A. Tanumihardjo. University of Wisconsin-Madison, Standard Process, Inc. 3:45 454.4 Regular Consumption of a Functional Symbiotic Yogurt Increases Calcium Absorption in Young Adult Women. R. Cornes, A. Peña, C. Sintes, S. Albin, K.O. O´Brien, C.M. Donangelo. Escuela de Nutrición, niversidad de la República, Uruguay, Division of Nutritional Sciences and Cornell University.

TUESDAY NUTRITION 4:00 454.5 Vitamin K Content of U.S. Dairy Foods and the Association with Fat Content. X. Fu, S.G. Harshman, X. Shen, D. Haytowitz, S.L. Booth. Tufts University and Beltsville Human Nutrition Research Center. 4:15 454.6 Anthocyanin Profiles and Contents in Processed Raspberries on the US Market. X. Wu, J. Sun, J. Ahuja, D.B. Haytowitz, B. Burton-Freeman, P. Chen, P.R. Pehrsson. Beltsville Human Nutrition Research Center and Illinois Institute of Technology. 4:30 454.7 Dietary Cranberry Alleviated Colonic Inflammation and Altered Gut Microbiota in Mice. X. Cai, M. Gu, M. Song, Z. Li, F. Li, T. Goulette, X. You, D.A. Sela, H. Xiao. University of Massachusetts Amherst. 4:45 454.8 improvement of Memory Impairment by Aqueous Extract of Asparagus officinalis L. is Related to Change of Intestinal Microflora in Mice. J. Sun, Z. Sui, C. Qi, Y. Huang, H. Xiao. Jiangnan University, People’s Republic of China, University of Massachusetts, Asparagus Engineering Technology Research Center of Hebei, People’s Republic of China.

455. IMPROVING THE DIETS OF VULNERABLE POPULATIONS Oral (Sponsored by: Global Nutrition Council) Tue. 3:00 pm—McCormick Place Convention Center, S102D Chaired: C. Stewart and S.L. Young 3:00 455.1 Adding a Water, Sanitation and Hygiene Intervention and a Lipid-Based Nutrient Supplement to an Integrated Agriculture and Nutrition Program Improved the Nutritional Status of Young Burkinabé Children. D.K. Olney, L. Bliznashka, E. Becquey, O. Birba, M. Ruel. International Food Policy Research Institute. 3:15 455.2 El Niño Southern Oscillation Affects Food Consumption, Intake, and Dietary Diversity in the Peruvian Amazon. R. Ambikapathi, M. Kosek, P. Yori, M. Paredes Olortegui, B. Zaitchik, G.O. Lee, A. Bauck, L. Caulfield. Johns Hopkins Bloomberg School of Public Health, Biomedical Investigations Unit AB PRISMA, Iquitos Peru., Peru, Johns Hopkins University and University of Michigan. 3:30 455.3 Association Between Household Food Insecurity and Dietary Diversity Among Pregnant and Lactating Women in Rural Malawi. Y. Kang, K. Hurley, A.B. Monclus, J. Ruel-Bergeron, R. Oemcke, L.S. Wu, M. Mitra, J. Phuka, R. Klemm, K. West, P. Christian. Johns Hopkins School of Public Health, University of Malawi, Malawi, Helen Keller International and Bill & Melinda Gates Foundation. 3:45 455.4 Risk Factors of Poor Complementary Feeding Practices in Pakistani Children Aged 6–23 Months: A Multi-Level Analysis of the Demographic and Health Survey 2012–2013. M. Na, V.M. Aguayo, M. Arimond, C.P. Stewart. University of California Davis and UNICEF.

4:00 455.5 Women’s Empowerment Is Associated with Maternal and Child Diet Diversity but Not Household Food Security in Pastoral Communities in Tanzania. A.W. Girard, I. Baltenweck, P. Dominguez-Salas, A. Galie, K. Harris, R. Jones, L. Korir, I.G. Raskind, N. Teufil, K.M. Yount. Rollins School of Public Health, Emory University, International Livestock Research Institute, Kenya, Royal Veterinary College, United Kingdom and London School of Hygiene and Tropical Medicine, United Kingdom. 4:15 455.6 Conceptualizations of Nutrition and Food Choice Behaviors Among Adolescent Girls and Young Women in Harare, Zimbabwe. C.B. Tinago, L. Annang Ingram, E.A. Frongillo, C.E. Blake, B. Engelsmann, D. Simmons. West Chester University of Pennsylvania, University of South Carolina and The Organization for Public Health Interventions and Development (OPHID) Trust, Zimbabwe. 4:30 455.7 Local Egg Production Centers Significantly Increase Maternal and Child Egg Consumption in Rural Zambia. S. Dumas, A.J. Travis. Cornell University. 4:45 455.8 Improving Children’s Diet and Nutritional Status Through an Agriculture Intervention with Nutrition Education in Upper Manya Krobo District of Ghana. G.S. Marquis, E.K. Colecraft, R. Kanlisi, C. Pinto, R. Aryeetey, B. Aidam, B. Bannerman. McGill University, Canada, University of Ghana, Ghana, Heifer Ghana, Ghana and World Vision International.

456. EARLY LIFE OBESITY: CAUSES, CORRELATIONS AND TREATMENT Oral Tue. 3:00 pm—McCormick Place Convention Center, S103A Chaired: M.I. Cardel and K. Moding 3:00 456.1 Folic Acid Content in Gestational Diet Elicits Dose-Dependent Changes on Hypothalamic Feeding Circuits in Wistar Rats at Birth. N.V. Yang, D. Chatterjee, E. Pannia, R. Kubant, G. Anderson. University of Toronto, Canada. 3:15 456.2 Both Paternal Exercise and Healthy Diet Are Required to Protect Offspring from High Fat Diet-Induced Obesity and Type 2 Diabetes Risk in Mice. K.J. Claycombe, D. Krout, R. Garcia, J. Roemmich. USDA AS GFHNRC. 3:30 456.3 Racial/Ethnic Disparities in Childhood Body Mass Index Trajectories and Potential Causes Among 29,254 US Children: The Early Childhood Longitudinal Study-Birth and Kindergarten Cohorts. Y. Wang, J. Min, X. Wen, H. Xue. Ball State University, University at Buffalo and The State University of New York. 3:45 456.4 Loss of a Healthy Weight Advantage Among Foreign-Born Children of Mexican Origin: An Analysis of Overweight/Obesity Trends from 1988–1994 to 2007–2014. L.E. Maldonado, S.S. Albrecht. University of North Carolina at Chapel Hill. 4:00 456.5 Patterns of Disordered Eating Are Associated with Weight Change in Family-Based Behavioral Obesity Treatment. K.N. Balantekin, J.F. Hayes, D.H. Sheinbein, R.P. Kolko, R.I. Stein, B.E. Saelens, R. Welch, M.G. Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley. Washington University School of Medicine, UPMC, Seattle Children’s Hospital, University of Florida and University at Buffalo.

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NUTRITION TUESDAY 4:15 456.6 Pre-Meal Television Viewing and Exercise on Subjective Appetite and Food Intake in Children. J.O. Totosy de Zepetnek, M. Da Silva, K. Miller, N. Bellissimo. Ryerson University, Canada. 4:30 456.7 Evaluation of “JenMe”, a Commercially Delivered Weight Management Program for Adolescents: A Randomised Controlled Trial. M.P. Bonham, A.L. Dordevic, R.S. Ware, H. Truby. Monash University, Australia, Menzies Health Institute Queensland, Griffith University, Australia and University of Queensland, Australia. 4:45 456.8 Changes in Lean Mass and Bone Parameters in Obese Children Participating in a Family-Centered Lifestyle Intervention: Results from a 1-Year RCT. T.R. Cohen, T.J. Hazell, C.A. Vanstone, C. Rodd, H.A. Weiler. McGill University, Canada, Wilfrid Laurier University, Canada and University of Manitoba, Canada.

457. MATERNAL FACTORS RELATED TO PREGNANCY, LACTATION AND INFANT HEALTH Oral

458. NONALCOHOLIC FATTY LIVER DISEASE AND LIVER METABOLISM Oral (Sponsored by: Medical Nutrition Council)

Maternal, Perinatal and Pediatric Nutrition RIS

Tue. 3:00 pm—McCormick Place Convention Center, S103D

Tue. 3:00 pm—McCormick Place Convention Center, S103BC

Chaired: S. Raatz

Chaired: S. Sen and K. Raghavan 3:00 457.1 Are You What Your Mother Ate: Maternal Artificially-Sweetened Beverages Intake During Pregnancy and Offspring Growth and Obesity Through Age 7 Years? Y. Zhu, S.F. Olsen, P. Mendola, T.I. Halldorsson, S. Rawal, S.N. Hinkle, E.H. Yeung, J.E. Chavarro, L.G. Grunnet, C. Granström, A.A. Bjerregaard, F.B. Hu, C. Zhang. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Kaiser Permanente Northern California, Statens Serum Institut, Denmark, University of Iceland, Iceland, Harvard T.H. Chan School of Public Health and Rigshospitalet University Hospital, Denmark. 3:15 457.2 Untargeted Metabolomics Reveal Disparate Metabolite Profile in Follicular Fluid Between Obese and Normal Weight Women. M.L. Ruebel, B.D. Piccolo, D.M. Moutos, K. Shankar, A. Andres. Arkansas Children’s Nutrition Center, Michigan State University, University of Arkansas for the Medical Sciences and Arkansas Fertility & Gynecology. 3:30 457.3 Plasma Alpha-Linolenic and Linoleic Acids in Early Pregnancy Are Associated with Birth Outcomes in Rural Malawi. B.M. Oaks, K.G. Dewey, K. Maleta, J.R. Sadalaki, U. Ashorn, W.S. Harris, P. Ashorn. University of California, University of Malawi College of Medicine, Malawi, University of Tampere School of Medicine, Finland, OmegaQuant Analytics, LLC and Tampere University Hospital, Finland. 3:45 457.4 Factors Shaping Breastfeeding Support Benefits in Workplaces: Perspectives of Human Resources Managers. A.L. MacMillan Uribe, T.A. Bolton, K. Woelky, B.H. Olson. University of Wisconsin-Madison and Ingham County Health Department. 4:00 457.5 Administration of Fluoxetine or a Small Molecule TPH1 Inhibitor Affects Litter Size, Pup Mortality, and Milk Yield During Murine Pregnancy and Lactation. S. Weaver, H. Fricke, L. Hernandez. University of Wisconsin-Madison.

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4:15 457.6 Milk Cell Gene Expression of Mothers with Low Breast Milk Production. D.T. Geddes, A. Twigger, D.L. Savigni, J.C. Kent, F. Kakulas. The University of Western Australia, Australia. 4:30 457.7 Impact of the Lactation Advice Through Texting Can Help (LATCH) Randomized Controlled Trial. J.L. MartinezBrockman, N. Harari, S. Segura-Perez, L. Goeschel, R. Perez-Escamilla. Yale University, Indian Health Service, Hispanic Health Council and CT Department of Public Health. 4:45 457.8 Novel Plasma Proteins in Nepalese SchoolAged Children Are Associated with a Small Head at Birth. S. Lee, K.P. West, R.N. Cole, K. Schulze, J.D. Yager, J. Groopman, P. Christian. Johns Hopkins Bloomberg School of Public Health and Johns Hopkins School of Medicine.

3:00 State of the Art Lecture. 3:30 458.1 Ablation of Systemic SIRT1 Activity Promotes Nonalcoholic Fatty Liver Disease by Affecting Liver-Mesenteric Adipose Tissue Fatty Acid Mobilization. J. Cheng, C. Liu, K. Hu, A. Greenberg, D. Wu, L.M. Ausman, M.W. McBurney, X. Wang. JM USDA-HNRCA at Tufts University, Tufts University Friedman School of Nutrition Science and Policy, Friedman School of Nutrition and Policy, Tufts University, University of Ottawa, Canada and Ottawa Hospital Research Institute, Canada. 3:45 458.2 Decaffeinated Green Tea and Voluntary Exercise Prevent Non-Alcoholic Fatty Liver Disease in Mice. W.Y. Khoo, S. Huang, B.J. Chrisfield, S. Sae-tan, J.D. Lambert. Penn State University and Kasetsart University, Thailand. 4:00 458.3 Role of Hepatic PLIN2 and PLIN4 in the Development of Western Type Diet Induced Hepatosteatosis. J.D. Griffin, D.M. Salter, T. Bowman, A. Greenberg. Tufts University. 4:15 458.4 Blackcurrant (Ribes nigrum) Consumption Prevents Non-Alcoholic Steatohepatitis in C57BL/6J Mice with Diet-Induced Obesity. Y. Lee, T.X. Pham, M. Bae, S. Hu, E. O’Neill, C. Han, C. Caceres, Y. Park, J. Lee. University of Connecticut. 4:30 458.5 Nicotinamide Riboside, an NAD+ Precursor, Attenuates the Activation of Hepatic Stellate Cells. T.X. Pham, M. Bae, J. Lee. University of Connecticut. 4:45 458.6 Biological Mediators Predict Liver Fibrosis Progression over Time in an HIV Mono-Infected Cohort. T. Stewart, A. Campa, S. Sales-Martinez, J. Hernandez Boyer, W. Wu, J. Liuzzi, M. Baum. University of Notre Dame and Florida International University.

TUESDAY NUTRITION

459. MICRONUTRIENT BIOAVAILABILITY, ANTIOXIDANT FUNCTION, ZINC, SELENIUM Oral Tue. 3:00 pm—McCormick Place Convention Center, S104A 3:00 459.1 Iron Absorption from Iron-Enriched Aspergillus oryzae Is Similar to Ferrous Sulfate in Humans. M.B. Reddy, S.M. Armah, J. Stewart, Y. Bian, A. Bries, K.O. O’Brien. Iowa State University, University of North Carolina Greensboro, Cura Global Health, Inc, and Cornell University. 3:15 459.2 Twenty-Four-Hour Urine Phosphorus Is Highly Variable in Patients with Moderate Chronic Kidney Disease on a Controlled Phosphorus Intake. E.R. Stremke, L.D. McCabe, G.P. McCabe, B.R. Martin, M. Wastney, S.M. Moe, C.M. Weaver, M. Peacock, K.M. Hill Gallant. Purdue University and Indiana University School of Medicine. 3:30 459.3 Metallothionein-2A mRNA in Peripheral Blood Mononuclear Cells Reflects Dietary Zinc Intake in Healthy Adults. S.R. Hennigar, J.P. Karl, A.M. Kelley, B.J. Anderson, N.J. Armstrong, H.L. McClung, C.E. Berryman, J.P. McClung. U.S. Army Research Institute of Environmental Medicine and Oak Ridge Institute for Science and Education. 3:45 459.4 Supplemental Zinc Decreases Fractional Zinc Absorption and Increases Lean Tissue Mass Among Vietnamese Children with Tuberculosis. A.G. Hall, N.T. Hoang, V.T. Hoang, L. Woodhouse, N. Tu, J.C. King, P.H. Vo. University of California at Davis, National Institute of Nutrition, Vietnam, National Lung Hospital, Vietnam, Western Human Nutrition Research Center, Children’s Hospital Oakland Research Institute and Institute for Nuclear Science and Technology, Vietnam 4:00 459.5 ZIP14 (SLC39A14) Is Required for Suppression of Apoptosis and Hepatic Steatosis Induced by ER Stress in Mouse Liver. M. Kim, T.B. Aydemir, J. Kim, R.J. Cousins. University of Florida. 4:15 459.6 Differential Regulation of Transcriptional Factors of Selenoprotein Genes by Moderately High Dietary Concentrations of Se and Fat in Liver and Adipose Tissue of Wildtype and Gpx1/Mice. Z. Zhao, J. Zhou, X. Lei. Cornell University. 4:30 459.7 Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice. W. Cheng, R.T. Wu, L. Cao, K.W. Witwer, H. Lu. Mississippi State University, University of Maryland at College Park and Johns Hopkins University. 4:45 459.8 The SELENOF Selenoprotein Localizes to the Outer Plasma Membrane in Human Prostatic Tissue and Its Levels Are Reduced in Prostate Cancer. D. Ekoue, E. Ansong, V. Macias, R. Deaton, A. Kajdacsy-Balla, L. Liu, C. Latcher, M. Picklo, L. Nonn, P. Gann, V. Freeman, A. Diamond. University of Illinois at Chicago and Grand Forks Human Nutrition Reseach Center.

460. NUTRIENT NEEDS/IMPACT ON AGING AND HEALTH Oral

3:15 460.2 Multiple Micronutrient Deficiencies Exist in Aged-Care Residents, with Serum Zinc, Not Iron, Being a Major Predictor of Anemia. S. MacDonell, J. Miller, M. Harper, M. Reid, J. Haszard, R. Gibson, L. Houghton. University of Otago and New Zealand, New Zealand. 3:30 460.3 Nutritional Supplementation with Physical Activity Improves Muscle Composition in Mobility-Limited Older Adults, the VIVE2 Study: A Randomized, Double-Blind, Placebo-Controlled Trial. D. Englund, D. Kirn, A. Koochek, T. Travison, K. Reid, Å. von Berens, H. Zhu, M. Lilja, T. Gustafsson, T. Cederholm, R. Fielding. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden, Institute for Aging Research, Hebrew SeniorLife, Department of Laboratory Medicine and Karolinska Institutet, Sweden. 3:45 460.4 The Effects of Iron Status on Testosterone Biosynthesis and Testicular Antioxidant Capacity in Male Rats. C. Tsao, Y. Liao, Y. Liew, Y. Lin, Y. Hsu, C. Liu. Tri-Service General Hospital, National Defense Medical Center, Taiwan and Fu Jen Catholic University, Taiwan. 4:00 460.5 α-Tocopherol—A Systematic Review of Intake and Status Globally. M. Eggersdorfer. DSM Nutritional Products, Switzerland. 4:15 460.6 Serum 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in US Adults: A Nationwide Population-Based Study. W. Bao, J.J. Oleson, L.G. Snetselaar. University of Iowa. 4:30 460.7 Elevated Levels of Circulating γ-Tocopherol as a Surrogate Marker of Mortality Risk in Populations of Adult Men Stratified by Health Index Score. R.V. Cooney, J.C. Wagner. University of Hawaii at Manoa. 4:45 460.8 N-3 Polyunsaturated Fatty Acids Increase Hepatic Fibroblast Growth Factor 21 Sensitivity Through PPARγ-β-klotho Pathway. W. Ling, W. Yang. Sun Yat-sen University, People’s Republic of China.

461. INTERNATIONAL COLLEGES FOR ADVANCEMENTS OF NUTROLOGY FORUM Forum Tue. 3:00 pm—McCormick Place Convention Center, S105A Chaired: S. Giorelli 3:00 3:20 3:40 4:00

Coffee’s Role as Functional Food and Medicinal Herb. Marcella Garcez Duarte. International Col. for Advancements of Nutrology. Obesity and Epigenetics. Rita Raman. Univ. of Oklahoma Health Sciences Ctr. Nutritional Support in Post-Bariatric Patients. Amy Ferreira Heyn. International Col. for Advancements of Nutrology. Sleep Deprivation and Obesity. Paulo Giorelli. International Col. for Advancements of Nutrology.

Tue. 3:00 pm—McCormick Place Convention Center, S104B Chaired: C.C. Sceppa and S.C. Chai 3:00 460.1 Prefrontal Cortex Structure Mediates the Relationship Between Plasma Phospholipid Stearidonic Acid and Fluid Intelligence in Healthy, Older Adults. M.K. Zamroziewicz, E.J. Paul, C.E. Zwilling, T. Das, S. Pereira, A.K. Barbey. University of Illinois Urbana-Champaign and Abbott Nutrition.

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Pathology 462. DISEASES OF THE ENDOPLASMIC RETICULUM Symposium Tue. 8:30 am—McCormick Place Convention Center, W179B

464. STOWELL SYMPOSIUM: TRENDS IN EXPERIMENTAL PATHOLOGY: GONE WITH THE WNT: A CLASSIC TALE OF STEM CELLS, CANCER AND MORE Symposium

Chaired: J. Lin and F. Urano Neuropathology

(Supported by an unrestricted educational grant from The Robert E. Stowell Endowment Fund)

Cell and Tissue Injury

Tue. 8:30 am—McCormick Place Convention Center, W180

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ER Stress in Human Photoreceptor Diseases. J. Lin. UCSD. 9:05 Podocyte ER Stress and Podocytopathies. Y. (Maggie) Chen. Washington Univ. Sch. of Med. 9:30 Insulin Gene Mutations. L. Philipson. The Univ. of Chicago. 10:05 Wolfram Syndrome, A Prototype of ER Stress-Mediated Beta Cell Death and Neurodegeneration. F. Urano. Washington Univ. Sch. of Med. 10:35 Progranulin: Connecting ER Stress and Lysosomal Protein Degradation in the Pathogenesis of Neurodegenerative Disease. A. Kao. UCSF. 11:00 ER Stress in the Inner Ear. M. Lesperance, Jochen Schacht. Univ. of Michigan, Univ. of Michigan.

463. SIPMET SYMPOSIUM: METABOLISM AND PREVENTION OF DISEASE Symposium (Sponsored by: Sponsored by ASIP and the Società Italiana di Patologia e Medicina Traslazionale /Italian Society of Pathology and Translational Medicine) Tue. 8:30 am—McCormick Place Convention Center, W181A Chaired: M. Corsi Romanelli Cardiac Pathobiology 8:30

Intestinal Microbiota: A NewEffective Actor Usually Unconsidered for the Prevention of Cancer. V. Castronovo. Univ. de Liege. 9:30 Heart Failure: Inflammasome, Necrosome and Signalosome. M. Willis. Univ. of North Carolina at Chapel Hill. 10:30 Epicardial Fat: From Biomolecular Aspects to Clinical Practice. M. Corsi Romanelli. Univ. of Milan.

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Chaired: S.P. Monga and D. Stairs Immunopathology Neoplasia 8:30

Wnt Signaling in Mensenchymal Stem Cells. T-C. He. The Univ. of Chicago Med. Ctr. 9:00 Enabling Developmental Competency to Pluripotent Stem Cells by Epigeneticaly Redirecting the Response to Wnt Signaling. B. Merrill. Univ. of Illinois at Chicago. 9:30 Control of T cell Development by Tcf-1 and ’-Catenin. F. Gounari. Univ. of Chicago. 10:00 Role of APC Defects and Beta-Catenin/TCF Dysregulation in Colon Cancer. E. Fearon. Univ. of Michigan. 10:30 The Effects of P120ctn on B-Catenin and Wnt Signaling In Head & Neck and Esophageal Squamous Cancers. D. Stairs. Penn State College of Med. 11:00 Wnt Signaling in Skeletal Disease. B. Williams. Van Andel Res. Inst.

465. REGULATION OF EPITHELIAL BARRIER INTEGRITY AND REPAIR Minisymposium Tue. 8:30 am—McCormick Place Convention Center, W181B Chaired: J. Waschke and J. Brazil Immunopathology Epithelial and Mucosal Pathobiology 8:30 465.1 Different Signaling Patterns Contribute to Loss of Keratinocyte Cohesion Dependent on Autoantibody Profile in Pemphigus. E. Walter, D. Egu, F. Vielmuth, L. Rotkopf, V. Spindler, J. Waschke. Ludwig-MaximiliansUniversität, Germany. 8:45 465.2 Intestinal Mucosa Pro-Repair Properties of Macrophage Derived IL-10 Are Mediated by CREB Triggered Epithelial WISP-1 Signaling. M. Quiros, H. Nishio, P.A. Neumann, G. Leoni, V. Garcia-Hernandez, D. Siuda, M. Feng, G. Bernal, R. Hilgarth, H. Williams, J.C. Brazil, P.H. Dedhia, J. Spence, C.A. Parkos, T.L. Denning, A. Nusrat. University of Michigan, Universität München, Germany, Institute for Cardiovascular Prevention, Germany, Emory University and Georgia State University.

TUESDAY PATHOLOGY 9:00 465.3 Adducin Regulates Migration and Invasion of Normal Lung Epithelial Cells and Lung Cancer Cells. S. Lechuga, P.H. Amin, A.I. Ivanov. Virginia Commonwealth University. 9:15 465.4 Desmoglein 2 Regulates the Intestinal Epithelial Barrier via p38 Mitogen-Activated Protein Kinase. H. Ungewiß. Institute of Anatomy and Cell Biology and LMU Munich, Germany. 9:30 465.5 Glial Cell-Line Derived Neurotrophic Factor Attenuates Inflammation-Induced Breakdown of Intestinal Epithelial Barrier Function by Stabilization of Dsg2-Dependent Intercellular Adhesion. M. Meir, N. Burkard, S. Flemming, C. Germer, J. Waschke, N. Schlegel. University Hospital Würzburg, Germany, University of Michigan and LudwigMaximilians-Universität München, Germany. 9:45 465.6 Synergistic Effects of Platelet Activating Factor and TNF-α in Promoting Intestinal Epithelial Migration and Mucosal Wound Repair. D. Siuda, M. Quirós, M. O´Leary, J. Brazil, B. Hinrichs, A. Neish, C. Parkos, A. Nusrat. University of Michigan and Emory University. 10:00 465.7 Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa to Inhibit Epithelial Wound Healing. R. Sumagin, A. Finkielsztein, T. Slater, L. Lorraine Mascarenhas, L. Mehl, V. Butin-Israeli. Northwestern University. 10:15 465.8 Desmoglein-2 Intracellular Cleavage and Intestinal Epithelial Barrier Compromise. M. Yulis, M. Quiros, R. Hilgarth, A. Nusrat. University of Michigan. 10:30 465.9 I tryptophan Metabolite Activation of the Aryl Hydrocarbon Receptor in Intestinal Epithelia Promotes Mucosal Healing. J.M. Lanis, E. Alexeev, S. Colgan. University of Colorado- Anschutz Medical Campus. 10:45 465.10 Desmoglein 2 Regulates Pancreatic Cancer Cell Migration Through Modulation of cAMP Levels. J. Zeiler, L. Sachs, V. Spindler. Ludwig-Maximilians-Universität München, Germany. 11:00 465.11 Hypoxia Inducible Factor (HIF)-1 Accelerates Epithelial Wound Healing Through Integrin Regulation. B.J. Goggins, K. Minahan, N. Outteridge, D. Knight, J. Horvat, S. Keely. University of Newcastle, Australia and Hunter Medical Research Institute, Australia. 11:15 465.12 Loss of Keratins Mimics p38MAPK-Mediated Pathogenic Effects of Autoantibodies in Pemphigus. F. Vielmuth, E. Walter, F. Loschke, T.M. Magin, V. Spindler, J. Waschke. Ludwig-Maximilians-Universität München, Germany and Leipzig University, Germany.

466. SCIENTIFIC SLEUTHING OF HUMAN DISEASE FOR UNDERGRADUATE STUDENTS AND HIGH SCHOOL TEACHERS AND STUDENTS Special Session (Sponsored by: Sponsored by the ASIP Education Committee) Tue. 9:30 am—Hyatt Regency McCormick Place, Regency Ballroom CD Chaired: K. Nejak-Bowen and M. Furie Pulmonary Pathobiology Immunopathology Neoplasia 9:30

10:00 Welcome and Introductions. K. Nejak-Bowen. Univ. of Pittsburgh. 10:20 Menacing Microbes: Emerging Infectious Diseases. M. Furie. Stony Brook Univ. 11:20 Smoking-Related Lung Disease in 3D: Not Your Standard Lecture. D. Zander. Pennsylvania State College of Med. 12:15 Stem Cells: A Case of Dr. Jekyll and Mr. Hyde. S.P. Monga. Univ. of Pittsburgh. 1:15 Tour the Exhibits at the McCormick Place Convention Center.

467. SOCIETY OF TOXICOLOGIC PATHOLOGY SYMPOSIUM: CHALLENGES IN TRANSLATION: CARDIOVASCULAR MODELING AS AN EXEMPLAR FOR IN VITRO TO IN VIVO EXTRAPOLATION Symposium (Sponsored by: ASIP Environmental and Toxicologic Scientific Interest Group and the Society of Toxicologic Pathology)

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Tue. 2:00 pm—McCormick Place Convention Center, W181A Chaired: E. Galbreath Cardiac Pathobiology Environmental and Toxicologic Pathology 2:00

Regulatory Genetic Variation Associated with Human Diseases. G. Gintant. AbbVie. 3:00 Predicting the Patient-Specific Cardiovascular Risk of Anti-Cancer Agents using hiPSC. P. Burridge. Northwestern Univ. 4:00 Integrated Strategies for Clinical Cardiovascular Risk Assessment in Nonclinical Studies. B. Berridge. GlaxoSmithKline.

468. TARGETING TRANSCRIPTION REGULATION IN DISEASE Symposium (Sponsored by: Sponsored by the Gene Expression Scientific Interest Group) Tue. 2:00 pm—McCormick Place Convention Center, W180 Chaired: P. Iannaccone, Q. Yan and D. Williams Gene Expression 2:00 Mitochondrial Gene Expression in Disease. G. Shadel. Yale Sch. of Med. 2:30 468.1 Histone Demethylase KDM5B Is Critical for PI3K-AKT-mTOR Signaling and Stemness of Melanoma. Q. Yan, S. Zhang, K. Meeth, G. Micevic, M. Bosenberg. Yale School of Medicine. 2:45 lncRNA Regulation of Gene Expression in Fate Specification and Disease. J. Kohtz. Northwestern Univ. 3:15 468.2 Epigenetic Re-Programming of Breast Cancer by Pharmacological Targeting of C-Terminal Binding Protein. J.S. Byun, K.L. Gardner. NIH.

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PATHOLOGY TUESDAY 3:30 Regulatory Genetic Variation Associated with Human Diseases. M. Nobrega. The Univ. of Chicago. 4:00 468.3 Dna Methylation, Hydroxymethylation and Formylation in Human Frontal Cortex of Autistic and Schizophrenic Subjects. M. Trivedi, R. Deth, Y. Zhang, H. Abdolmaleky. Nova Southeastern University, Northeastern University and Boston University. 4:15 Exploring the Methyl-Cytosine Binding Domain Family as Potential Therapeutic Targets. D. Williams. Univ. of North Carolina.

469. MUCOSAL INFLAMMATION AND EPITHELIALLEUKOCYTE INTERACTIONS Minisymposium Tue. 2:00 pm—McCormick Place Convention Center, W179B Chaired: S.P. Colgan and S. Keely Epithelial and Mucosal Pathobiology Immunopathology Inflammation 2:15 469.2 Novel Role of Lewis a Glycans in Regulating Neutrophil Trafficking. J.C. Brazil, R. Sumagin, G. Lee, N.A. Louis, R.D. Cummings, C.A. Parkos. University of Michigan, Northwestern University, University of Ottawa, Canada, Emory University and Beth Israel Deaconess Medical Center. 2:30 469.3 Gut Microbial Metabolites Establish a Gradient of Extracellular Protons, Which Mediate Microbiota-Stimulated Intestinal Repair via Proton-Sensing G-Protein CoupledReceptors. M. Alam, H. Wu, J. Matthews, B. Saeedi, R. Jones, A.S. Neish. Emory University School of Medicine. 2:45 469.4 Selective Intestinal Epithelial Loss of Junctional Adhesion Molecule-A Results in Enhanced Intestinal Permeability and Increased Susceptibility to Colitis. S. Flemming, A. Luissint, A. Nusrat, C.A. Parkos. University of Michigan Medical School. 3:00 469.5 The Influence of ENPP1 Expression in Mucosal Tissues. V. Curtis, R. Wang, K. Battista, J.S. Lee, S. Colgan. University of Colorado Anschutz Medical Campus. 3:15 469.6 CD47 Regulates CDd11b-Dependent Neutrophil Transepithelial Migration During Intestinal Inflammation. V. Azcutia, A. Luissint, S. Flemming, M. Quiros, A. Nusrat, F.W. Luscinskas, C.A. Parkos. University of Michigan and Brigham and Women’s Hospital and Harvard Medical School. 3:30 469.7 Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Efferocytosis by Porcine Macrophages and Modulation of Lipid Mediators of Inflammation in Vitro: A New Class of Anti-Microbial with Anti-Inflammatory and Pro-Resolution. R. Moges, D. Desmonts de Lamache, G.P. Muench, E.M. Abbott, A.G. Buret. University of Calgary, Canada and ECO Animal Health London, United Kingdom. 3:45 469.8 Increased Intestinal Permeability Secondary to Junctional Adhesion Molecule-A Deficiency Results in Impaired Macrophage-Dependent Neutrophil Recruitment in a Zymosan Peritonitis Model. A. Luissint, H.C. Williams, W. Kim, R.S. Hilgarth, M. O’Leary, S. Flemming, M. Reed, T.L. Denning, A. Nusrat, C.A. Parkos. University of Michigan, Emory University School of Medicine, Kyung Hee University, Republic of Korea, and Institute for Biomedical Sciences.

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4:00 469.9 Microbiota-Derived Tryptophan Metabolites Provide a Novel Pathway for Regulation of Mucosal Barrier Function. E.E. Alexeev, J.M. Lanis, D.J. Kao, K.D. Battista, C.J. Kelly, E.L. Campbell, D.J. Kominsky, S.P. Colgan. University of Colorado, Anschutz Medical Campus and Montana State University. 4:15 469.10 Neutrophils Induce Pro-Angiogenic T Cells with a Regulatory Phenotype in Pregnancy. S. Nadkarni, J. Smith, A. Sferruzzi-Perri, M. Kishore, C. Mauro, D. Williams, F. Marelli-Berg, M. Perretti. Queen Mary, University of London, United Kingdom, Cambridge University, United Kingdom and University College London, United Kingdom. 4:30 469.11 Intestinal P-Glycoprotein Exports Endogenous Cannabinoids at the Epithelial Surface to Prevent Inflammation and Maintain Homeostasis. R.L. Szabady, R.J. Mrsny, B.A. McCormick. UMass Medical School and University of Bath, United Kingdom. 4:45 469.12 Lack of NF-κB-Inducing Kinase (NIK) Results in Eosinophilic Esophagitis (EoE) and Gastric Hyperplasia in Mice: Implications for Noncanonical NF-κB Signaling in Human EoE. K. Eden, D.K. McDaniel, B. Heid, I.C. Allen. Virginia Maryland College of Veterinary Medicine.

470. CELL INJURY, AUTOPHAGY, AND DNA DAMAGE Minisymposium Tue. 2:00 pm—McCormick Place Convention Center, W181B Chaired: T. LaBranche and C. Yates Cell and Tissue Injury Cell Death 2:00 470.1 Autophagy Regulates Hepatocellular Senescence. N. Huda, B. Khambu, X. Chen, X. Yin. Indiana University School of Medicine. 2:20 470.2 Neuregulin-1β Induces Erbb3-Dependent Proliferation and Survival of Normal Human Cardiac Ventricular Fibroblasts. C.L. Galindo, A. Kirabo, M. Gupte, S. Ryzhov, D.B. Sawyer. Vanderbilt University Medical Center and Maine Medical Research Center. 2:40 470.3 The Nrf2 Transcription Factor Promotes Efferocytosis by Activating Phosphatidyl Serine Receptor Tim-4 Signaling During Oxidant-Induced Lung Injury Repair. N.M. Reddy, C.R. Tamatam, S.P. Reddy. University of Illinois at Chicago. 3:00 470.4 Palmitate Increases Ubiquitination in H4IIE and Primary Rat Hepatocytes. C.M. Stewart, A.L. Estrada, P.Y. Kim, D. Wang, Y. Wei, M. Pagliassotti. Colorado State University and Grambling State University. 3:20 470.5 Function of TGF-β Regulated NcRNAas in Cardiac Hypertrophy. X.Yang. Beijing Institute of Biotechnology, People’s Republic of China. 3:40 470.6 Quantitative Real Time PCR (qRT-PCR) Evaluation of Pig Mitochondrial DNA Damage. J.L. Barr, T.W. Thomas, R.S. Gibson, M.A. Dubick, P.D. Bowman. US Army Institute of Surgical Research. 4:00 470.7 Diesel Exhaust Particle Exposure Compromises Macrophage Mitochondrial Physiology. J. Gibbs, B. Dallon, J. Lewis, J.S. Tessem, P.R. Reynolds, B.T. Bikman. Brigham Young University and Brigham Young University.

TUESDAY PATHOLOGY 4:20 470.8 Initial Autophagic Protection Switches to Disruption of Autophagic Flux by Lysosomal Instability During Cadmium Stress Accrual in Renal NRK-52E Cells. F. Thevenod, W. Lee, M.P. Santoyo-Sánchez, S. Probst, E. Kerek, E.J. Prenner. University of Witten/Herdecke, Germany and University of Calgary, Canada. 4:40 470.9 Pyruvate Dehydrogenase Kinase 4 Deficiency Induces Hepatic Apoptosis by Activating NF-κB/TNFα Signaling. J. Wu, J. Choiniere, M. Lin, L. Wang. University of Connecticut, Wenzhou Medical University, People’s Republic of China, Veterans Affairs Connecticut Healthcare System and Yale University.

471. CLUB HEPATOMANIA (LIVER PATHOBIOLOGY) SCIENTIFIC INTEREST GROUP NETWORKING SESSION Special Session

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472. SCIENTIFIC INTEREST GROUP POSTER DISCUSSION AND NETWORKING SESSION Poster Discussion Tue. 5:30 pm—McCormick Place Convention Center, W375B P1

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Adjuvant Statin Therapy Efficacy Is Dictated by Tumor Dormancy and Statin Lipophilicity in ex Vivo and in Vivo Models of Metastatic Breast Cancer. C.H. Beckwitt, A.M. Clark, K. Warita, Z.N. Oltvai, A. Wells. University of Pittsburgh and Tottori University, Japan. (807.13) 3,4,2,4 Tetrahydroxychalcone (Butein) Inhibition of TNFα-Induced CCL2 Release in Triple Negative Breast Cancer Cells. A.C. Horton, D.F. Bauer, K.F. Soliman. Florida A&M University. (809.1) MiR-105/93-3p Promotes Metastasis, Chemoresistance and Stemness in TNBC and Circulating miR105/93-3p Act as Predictive Biomarker for TNBC Chemoresistance. H. Li, P. Lu. National Cheng Kung University, Taiwan. (809.2) Apigenin Modulation of Whole Transcriptome Patterns of TNFα-Induced Changes in Triple Negative Breast Cancer Cells, MDA-MB-231. D. Bauer, E. Mazzio, K.F. Soliman. Florida A&M University. (809.3)

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Quercetin Inhibition of TNFα-Induced CCL28 Release from Human Triple Negative Breast Cancer (MDAMB-468) Cells. T.F. Buchanan, D. Bauer, K.F. Soliman. Florida A&M University. (809.4) Exploring Molecular and Morphological Relationships Between Obesity and Ctbp in Breast Cancer. S. Park, T. Yan, L. Crawford, D. Li, A. Jones, A. Caban, S. Gil-Hernandez, M. Kabbout, D. Yi, S. Ambs, V. Periwal, J. Byun, K. Gardner. NCI, NIMHD and NIDDK. (806.6) Glutamine Transporter Expression Profiling in Murine Breast Cancer Reveals Therapeutic Targets for Triple Negative Breast Cancer. C. Kron, B. Bode. Northern Illinois University. (809.6) Enlarged Endosomes and Altered Transferrin Recycling in Breast Cancer Cells. K.E. Tubbesing, A. Malhotra, A. Rudkouskaya, M. Barroso. Albany Medical College. (809.11) Knockout of the PHLDA1 Gene in Breast Cancer Cells Reveals Multiple Roles for PHLDA1 in Cancer Phenotypes. A.M. Zimnicka, T. Sharma, M. Regan, B.J. Merrill, J. Frasor. University of Illinois at Chicago. (178.8) Hypoxia Stimulates an Increase of Neuropeptide Y Y1 and Y5 Receptor Expression in Human Breast Cancer Cells. P.J. Medeiros, J. Uniacke. University of Guelph, Canada. (809.12) Exploring the Relationship Between Kaiso and C-Terminal Binding Protein in Breast Cancer in Women of African Ancestry. A.B. Caban-Ureña, A. Jones, J. Shin, S. Park, S. Gil-Hernández, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. (809.9) C-Terminal Binding Protein and Snail: Understanding the Roles of Metabolic Imbalance and EMT in Breast Cancer Disparities. A. Jones, A. Caban-Ureña, S. Park, S. Gil-Hernández, J. Shin, T. Yan, M. Kabbout, G. Liang, J. Byun, K. Gardner. National Institute on Minority Health and Health Disparities and National Cancer Institute. (806.5) Alcohol Abuse Promotes Breast Cancer Development and Progression via StarD10 Phosphorylation. A. Floris, C. Cossu, Y. Spissu, M. Tomasi. Cedars-Sinai Medical Center. (806.2) Uncoupling Effects of ERα on LKB1/AMPK Signaling Induced by Adiponectin in Breast Cancer Cells. L. Mauro, G.D. Naimo, L. Gelsomino, E. Spina, M.L. Panno, S. Andò. University of Calabria, Italy. (809.14) Induction of Paclitaxel Resistance in Human Breast Cancer Cell by JNK/SAPK-Inhibitory Kinase Through MAPK14/RELA/PTGS2 Signaling. T. Lai. Genomics Research Center and Academia Sinica, Taiwan. (809.10) Mangenese Superoxide Dismutase (MnSOD) Promotes Stem-Like Cell Phenotypes in Breast Cancer. C. He, P. Hart, K. Fricano, M. Vargas, K. Thieraud, A. Luelsdorf de Abreu, M. Bonini University of Illinois at Chicago. (809.15)

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The Role of Metastasis-Associated Protein 1 (MTA1) in Breast Cancer Exosome-Mediated Intercellular Communication. B.N. Hannafon, K. Gaskill, C. Calloway, W. Ding. University of Oklahoma Health Sciences Center. (178.6) Three-Dimensional Histochemistry and Imaging of Extracellular Matrix-Rich Human Tissues. C.J. Van Noorden. Academic Medical Center, Netherlands. (980.5) Pulsed-Wave Doppler Blood Flow Through the Pulmonary Trunk as a Valuable Method to Determine Cardiac Output Following Myocardial Infarction. M.J. Platt, J.S. Huber, K.R. Brunt, J.A. Simpson. University of Guelph, Canada and Dalhousie Medicine, Canada. (977.1) Autonomic Nervous Tone During Histopathological Diagnosis of Oral Squamous Cell Carcinoma in Virtual Images. E.A. Mondragon. Universidad Militar “Nueva Granada”, Colombia and Universidad de la Sabana, Colombia. (983.4) Quantitative Image Analysis of Traumatic Brain Injury Induced Aspiration Pneumonia Treatment. C.C. Howell, G.E. Sandusky. Indiana University-Purdue University Indianapolis. (983.1) The Role of IQGAP1 in Transendothelial Migration: From in Vitro Identification to in Vivo Validation. D.P. Sullivan, P.J. Dalal, W.A. Muller. Northwestern University. (978.16) Surface Area May Be a More Useful Risk Factor for Cerebral Aneurysm Rupture Than Maximum Diameter. S. Fukuda, Y. Shimogona. Kyoto Medical Center, Japan and Tohoku University, Japan. (659.17) Aberrant Histone Turnover in Alzheimer’s Disease. J.A. Dowell, M.A. Gitcho, J.M. Denu. Wisconsin Institutes for Discovery, Delaware State University and University of Wisconsin. (659.10) An Integrated Study of Gene Expression Profile Uncovers Similarity Between Embryogenesis, Bone Development, Wound Healing, and Prostate Cancer. T.S. Rayburn, A. Mukherjee, W.A. Byrd, J. Jones. Troy University. (980.2) Identification of Key Transcription Factor Target Interactions That Regulate Prostate Cancer Metastasis. N. Sharma, K.L. Pellegrini, F.O. Giuste, V. Ouellet, D. Trudel, A. Mes-Masson, F. Saad, A.O. Osunkoya, J. Petros, C.S. Moreno. Emory University and University of Montreal, Canada. (980.3) Inhibition of HDAC, Especially HDAC3, Prevents Diabetic Cardiomyopathy in OVE26 Mice via Epigenetic Inhibition of ERK1/2-DUSP5 Pathway. Z. Xu, L. Cai. The First Hospital of Jilin University, People’s Republic of China, Kosair Children Hospital Research Institute and University of Louisville. (977.4)

P28

Epigenetic Regulation of Stab2 Expression in DBA Mice in Determining Atherosclerosis Susceptibility. S. Dong, Y. Kayashima, N. Maeda. UNC-Chapel Hill. (979.4) P29 The Nrf2 Transcription Factor Promotes Efferocytosis by Activating Phosphatidyl Serine Receptor Tim-4 Signaling During Oxidant-Induced Lung Injury Repair. N.M. Reddy, C.R. Tamatam, S.P. Reddy. University of Illinois at Chicago. (470.3) P30 Function of TGF-β Regulated NcRNAas in Cardiac Hypertrophy. X. Yang. Beijing Institute of Biotechnology, People’s Republic of China. (470.5) P31 Withdrawn. (979.1) P32 lncRNAH19/ZEB1/EpCAM Regulatory Axis in Cholestatic Liver Fibrosis. Y. Song, C. Liu, L. Wang. University of Connecticut. (328.6) P33 Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in HepatocyteDriven Liver Regeneration. J.O. Russell, S. Ko, D. Shin, S.P. Monga. University of Pittsburgh. (531.7) P34 Epigenetic Re-Programming of Breast Cancer by Pharmacological Targeting of C-Terminal Binding Protein. J.S. Byun, K.L. Gardner. NIH. (468.2) P35 miR-16 Mediated MYB Gene Silencing Induces Fetal Hemoglobin Expression. C.R. Pounds, M. Takezaki, B. Li, C. Ward, N. Lopez, B.S. Pace. Medical College of Georgia at Augusta University. (979.6) P36 Expression of Matricellular Protein CCN1 in the Tumor Stroma Is Required for Melanoma Metastasis. A. Leask, L. Postovit, K. Quensel, J. Hutchenreuther. Western University, Canada and University of Alberta, Canada. (808.3) P37 Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis. H. Qazi, Z-D. Shi, J.W. Song, L.M. Cancel, L.L. Munn, J.M. Tarbell. The City College of The City University of New York, Sloan-Kettering, The Ohio State University and Massachusetts General Hospital. (808.6) P38 Assessing the Effects of TIMP2 Knockout on Lung Cancer Cell Lines Cultured in 3D. D. Peeney. NCI. (808.4) P39 Solute Carrier Family 2 Member 4 Regulates TRIM24DDX58 Axis to Promote Head and Neck Cancer Metastasis. Y. Chang, M. Hsiao. Academia Sinica, Taiwan. (808.5) P40 Withdrawn. (976.2)

TUESDAY PATHOLOGY P41

Localization of Scleraxis in Dermal and Keloid Fibroblasts. C. Johnson, A. Nillas, T.A. Reaves. Medical University of South Carolina. (182.1) P42 Adducin Regulates Migration and Invasion of Normal Lung Epithelial Cells and Lung Cancer Cells. S. Lechuga, P.H. Amin, A.I. Ivanov. Virginia Commonwealth University. (465.3) P43 The Role of Scleraxis in Neutrophil Activation. O. Awotunde, A. Nillas, S. Hammad, T.A. Reaves. University of Maryland Baltimore County, University of SC School of Medicine and Medical University of SC. (182.2) P44 Thymosin Beta 4 Influences Hedgehog Signaling by Interacting with Smo-Gli2 in Hepatic Stellate Cells. J. Kim, Y. Jung. Pusan National University, Republic of Korea. (804.13) P45 The Assessment of Clinically Relevant Extracellular Matrix Markers in a Bleomycin-Induced Mouse Model of Lung Fibrosis. A. Young, P. Nath, D. Leeming, M. Karsdal, S. Brockbank, D. Rider, S. Cruwys. Discovery, Charles River, United Kingdom, Nordic Biosciences, Denmark and Grunenthal, Germany. (656.18) P46 A Role of IL-21 in Pulmonary Fibroblast Activation. R. Sathiaseelan, C. Huang, L.K. Senavirathna, L. Liu. Oklahoma State University. (656.15) P47 Phospholipase D Regulates GSK3β mediated Epithelial to Mesenchymal Transition and Akt Mediated Cell Death Leading to Pulmonary Fibrosis. V. Suryadevara, T.J. Royston, V. Natarajan. University of Illinois. (656.2) P48 Multipotent Stromal Cell and Fibroblast CoTransplantation Alter Wound Microenvironment to Normalize Aged-Deficient Wound Healing. B. Lantonio, M. Rosano, B. Brown, A. Wells, C.C. Yates. University of Pittsburgh. (333.3) P49 Cytoprotective Chaperone Proteins Are Novel AntiInflammatory Targets in Sickle Cell Disease. C. Anea, S. Kumar, I. Lee, J. Brittain. Augusta University. (981.3) P50 ATF3 Protects LPS-Induced Acute Pancreatic Inflammation via Modulating NFκB-Mediated iNOS Production in Mice. Y. Chen, Y. Tseng, C. Liu, H. Lin, C. Cheng, P. Lai. Tzu Chi University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Taipei Medical University, Taiwan. (657.2) P51 Pro-Inflammatory and Anti-Inflammatory Cytokine Expression in Tnf -/- and WT Mice with Chronic Colitis. T.M. Smith, A. Kozik, C.H. Nakatsu, Y.L. Jones-Hall. Purdue University. (657.4) P52 Paradoxical Effects of PGC-1 Isoforms on Retinal Pigment Epithelium: Implication for Neovascular Retinal Diseases. M. Saint-Geniez, Q. Charles, M. Rosales, A. Khadka, J. Iacovelli. Harvard Medical School, Schepens Eye Research InstituteMassachusetts Eye and Ear Infirmary and Boston University. (976.11)

P53

Effects of High Fat Diet on 4-NQO-Induced Changes in a Variety of Tissues in a Mouse Model of Oral Cancer. J. Goral, A. Meyer, L. Pitstick, M. Pytynia, R. Schmelter, F. Syed, A. Barakat, D. Oswald, A. Gladding, J. Pescatore, J.M. Green, M.J. Ciancio, B. Jham. Midwestern University. (806.3) P54 The Unfolded Protein Response Regulates Pancreatic Neuroendocrine Tumor Growth. S.A. Oakes, J.Y. Qi, P.C. Moore, R.A. Warren, M. Thamsen, R. Ghosh, M.J. Gliedt, D.J. Maly, B.J. Backes, F.R. Papa. University of California San Francisco and University of Washington. (178.4) P55 How the Cytosol-To-Membrane Translocation Kinetics and Signaling of PKCγ Are Dysregulated in the Neurodegenerative Spinocerebellar Ataxia Type14 (SCA14). N. Aslam, F. Alvi. BioSystOmics and COMSAT Institute of Information Technology, Pakistan. (183.4) P56 Model Systems to Study the Pathogenesis of Zika VirusMediated Eye Disease. L.E. Martinez, D. Contreras, M.K. Jones, V. Gangalapudi, J. Tang, S. Wang, V. Arumugaswami. Cedars-Sinai Medical Center. (658.12) P57 Automated Fluorescent Miscroscopic Image Analysis of PTBP1 Expression in Glioma. B. Goksel, E. Goceri, B. Elder, V. Puduvalli, M. Gurcan, J.J. Otero. The Ohio State University. (980.1) P58 PSEN1 as an Adjunct for Diagnosis of Human Myocarditis. P.J. Hanson, E.L. Jang, H. Rai, A.Y. Chang, A.Y. Mo, B.M. McManus, M.A. Seidman. University of British Columbia, Canada and Providence Health Care, Canada. (977.2) P59 Fibrinogen Alpha Is the Precursor Protein of Cardiac Valve Amyloidosis. K. Miura, H. Katoh, T. Tsuchida. Hamamatsu University School of Medi, Japan and Kosai Hospital, Japan. (977.7) P60 Use of Anchored Multiplex PCR Enrichment for Detection of Gene Fusions in Solid Tumors by Next Generation Sequencing. D.C. Green, S.J. Deharvengt, F.B. de Abreu, H.B. Steinmetz, J.D. Peterson, G.J. Tsongalis. Dartmouth Hitchcock Medical Center, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center and Geisel School of Medicine. (807.20) P61 Molecular Diagnostic Techniques Used to Confirm an Unusual Case of BAPoma. A. Atkinson, K. Linos, S. Yan, G. Tsongalis, J. Lefferts. Dartmouth-Hitchcock Medical Center. (807.17) P62 Integrin β6: Lost in Translation from Mouse to Human as a Target for Hepatic Fibrosis. C. Saravanan, Y. Song, P. Wu, W. Hu, F. Bian, A. Heidt, K. Mansfield. Novartis Institutes for Biomedical Research Institutes (NIBR), NIBR, People’s Republic of China, and The Genomics Institute of the Novartis Research Foundation. (804.10)

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Kinesiological Benefits of Botulinum Toxin Type A Combined with Exercise on the Functional Recovery After Spinal Cord Injury. Y. Jin, S. Park, Y. Hong. Graduate School of Inje University, Republic of Korea, Inje University, Republic of Korea. (981.2) P64 Dna Methylation, Hydroxymethylation and Formylation in Human Frontal Cortex of Autistic and Schizophrenic Subjects. R. Deth, Y. Zhang, H. Abdolmaleky, M. Trivedi. Nova Southeastern University, Northeastern University and Boston University. (468.3) P65 Cyclin A2 Loss Impairs Hippocampal Development. M. Goksel, P. Gygli, J. Chang, B. Goksel, H.N. Gokozan, R. Nelson, C. Czeisler, J.J. Otero. The Ohio State University. (659.2) P66 Visualization of Neuronal Connectivity in NPARM PHOX2b Mutants with a Modified PACT Protocol. S.R. Fair. The Ohio State University. (659.3) P67 A Novel Neuroprotective Effect of Osteoactivin in Parkinson’s Disease. K.M. Budge, G. Alam, M. Edler, J. Richardson, F. Safadi. Kent State University and Northeast Ohio Medical University. (183.1) P68 Regulator of G-Protein Signaling 6 (RGS6) Expression in Human Substantia Nigra Pars Compacta (SNc) and Loss in Parkinson’s Disease (PD). Z. Luo, K.E. Ahlers, J. Yang, B. Chakravarti, H.E. Stevens, N.S. Narayanan, R.A. Fisher. The University of Iowa. (659.23) P69 Investigating the Underlying Mechanisms of Chemosensory Dysfunctions in Alzheimer’s Disease Using Caenorhabditis elegans with Mutations in Presenilin 1. M. Parvand, T. Bozorgmehr, C. Rankin. University of British Columbia, Canada. (659.9) P70 Caffeine May Affect Apoptosis and Autophagy Activity to Promote Dopaminergic Cells Survival Under the Rotenone Induced Parkinson Disease Model. C. Luo, Y. Huang, B. Huang, T. Lu, Y. Fu. Department of Biomedical Science and Environmental Biology, Kaohsiung Medial University, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Taiwan, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Department of Biomedical Science and Environmental Biology, Center for Infectious Disease and Cancer Research and Kaohsiung Medical University, Taiwan. (659.8) P71 Assessing Gliogenesis in a Murine Multifactorial Brain Injury Model System. M.S. Domowicz, N.L. Wadlington, J.G. Henry, K. Diaz, M.J. Munoz, N.B. Schwartz. University of Chicago. (183.3) P72 High Fat Diet Increases Cognitive Decline and Neuroinflammation in a Model of Orexin Loss. C.M. Duffy, J.P. Nixon, T.A. Butterick. Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota’s Discovery, Research, and Innovation Economy, Brain Conditions and Minnesota Obesity Center. (659.12)

150

P73

APOE Genotype Influences Glial Activity in MS. Z. Langston, M. Lahey, A. Affaneh, E. Cudaback. DePaul University. (659.15) P74 The Effect on the Content of Nogo-A in the Damage Area of the Rats Brain with Fasudil After Traumatic Brain Injury. H. Duan, C. Hao, C. Liu, S. Li, L. Gao, X. Zheng. The First Clinical College of Shanxi Medical University, People’s Republic of China, The First Hospital of Shanxi Medical University, People’s Republic of China. (183.5) P75 Modeling the Ischemic Neurovascular Unit in a Dish Using Patient-Specific Induced Pluripotent Stem Cells. S. Page. TTUHSC. (659.20) P76 Animating External Magnetic Guidance of Intrathecally Delivered Gold-Coated Nanoparticles to Treat Intramedullary Spinal Tumors. A. Orland, K. Brennan, L. Lebowicz, C. Wellman, A. Mehta. University of Illinois at Chicago. (659.21) P77 Development of a Silver Methenamine Masson Trichrome (SMMT) Stain for Use in Sheep Kidneys. M. Smith, K. Wyatt, J. Weng, A.S. Davis. College of Veterinary Medicine and Kansas State University. (983.2) P78 Spectral Domain Optical Coherence Tomography Correlates Retinal Thinning to Retinal Vascular Development in an in Vivo Mouse Model of Retinopathy of Prematurity. O.J. Mezu-Ndubuisi, L.K. Taylor, J.A. Schoephoerster. University of Wisconsin. (978.2) P79 Cathepsin K Cleavage of SDF-1α Inhibits Its Chemotactic Activity Toward Glioblastoma StemLike Cells in Their Niches. V. Hira, U. Verbovšek, B. Breznik, H. Kakar, J. Wormer, B. Van der Swaan, S. Mehta, T. Lah, C. Van Noorden. Academic Medical Center, Netherlands, Barrow Neurological Institute and National Institute of Biology, Slovenia. (808.2) P80 Enteroaggregative Escherichia coli Delocalized B-Catenin Adherens Junction in Ileum and Colon Enterocytes in an Infection Mouse Model with a Disturbed Microbiota. N.E. Moran García, C. LopezSaucedo, S. Galindo-Gómez, V. Tsutsumi, A. Felipe-Lopez, M. Schnoor, J.P. Nataro, T. EstradaGarcia. CINVESTAV-IPN, Mexico and University of Virginia School of Medicine. (184.3) P81 Internalization and Trafficking of PD-L1 in MDAMB231 Breast Cancer Cells. A. Rudkouskaya, M. Barroso. Albany Medical College. (809.7) P82 Sex Dependent Role of Activating Transcription Factor 3 (ATF3) Expression in Modulating the Asthmatic Phenotype in an Acute Mouse Model of Airway Neutrophilia. A. Spinelli, N. Fuentes Ortiz, M. Nicoleau, U. Sinha, C.R. Caruso, S. DiAngelo, Z. Chroneos, P. Silveyra Penn State College of Medicine and MS Hershey Medical Center. (656.9) P83 STAT3 and MEK Mediate IL6-Induced Increase in Endothelial Permeability. H. Alsaffar, N. Martino, A. Adam. Albany Medical College. (55.6)

TUESDAY PATHOLOGY P84

Atrogin-1 Transgenic (At1 Tg+) Mice Have AgeDependent Cardiac Dysfunction with Atrogin-1 Mediated Glucocorticoid Receptor (GR) Expression Down Regulation. R. Mota, T. Parry, M. Willis. UNC at Chapel Hill. (59.5) P85 Effect of Mitoquinone Treatment on Cardiac Function and Pathophysiology in Pressure Overload-Induced Heart Failure. K. Goh, A.R. Wende, R.N. Soorappan, G. Halade, V. Darley-Usmar, M. Jinno, S.D. Prabhu, L. Zhou. University of Alabama at Birmingham. (59.7) P86 Neuroanatomical Analysis of a Conditional Knockin Mutant PHOX2B Mouse Model. J. Liu, C. Czeisler, S. Fair, B. Goksel, M. Goksel, J. Otero. The Ohio State University. (183.2) P87 Pyruvate Dehydrogenase Kinase 4 Deficiency Induces Hepatic Apoptosis by Activating NF-κB/ TNFα Signaling. J. Wu, J. Choiniere, M. Lin, L. Wang. University of Connecticut, Wenzhou Medical University, People’s Republic of China, Veterans Affairs Connecticut Healthcare System and Yale University. (470.9) P88 Gut Microbial Metabolites Establish a Gradient of Extracellular Protons, Which Mediate MicrobiotaStimulated Intestinal Repair via Proton-Sensing G-Protein Coupled-Receptors. M. Alam, H. Wu, J. Matthews, B. Saeedi, R. Jones, A.S. Neish. Emory University School of Medicine. (469.3) P89 CD47 Regulates CDd11b-Dependent Neutrophil Transepithelial Migration During Intestinal Inflammation. V. Azcutia, A. Luissint, S. Flemming, M. Quiros, A. Nusrat, F.W. Luscinskas, C.A. Parkos. University of Michigan and Brigham and Women’s Hospital and Harvard Medical School. (469.6) P90 Entamoeba histolytica Stimulates the Release of the Alarmin Molecule HMGB1 by a PI3 Kinase Dependent Mechanism. S. Begum, F. Moreau, J. St-Pierre, K. Chadee. University of Calgary, Canada. (55.2) P91 Hypoxia Inducible Factor (HIF)-1 Accelerates Epithelial Wound Healing Through Integrin Regulation. B.J. Goggins, K. Minahan, N. Outteridge, D. Knight, J. Horvat, S. Keely. University of Newcastle, Australia and Hunter Medical Research Institute, Australia. (465.11) P92 I tryptophan Metabolite Activation of the Aryl Hydrocarbon Receptor in Intestinal Epithelia Promotes Mucosal Healing. J.M. Lanis, E. Alexeev, S. Colgan. University of Colorado- Anschutz Medical Campus. (465.9) P93 Giardia duodenalis alters Intestinal Mucin Transcription and Disrupts the Mucus Layer in a Cysteine ProteaseDependent Manner. C.B. Amat, J. Motta, K. Chadee, A.G. Buret. University of Calgary, Canada. (184.2) P94 Glial Cell-Line Derived Neurotrophic Factor Attenuates Inflammation-Induced Breakdown of Intestinal Epithelial Barrier Function by Stabilization of Dsg2Dependent Intercellular Adhesion. M. Meir, N. Burkard, S. Flemming, C. Germer, J. Waschke, N. Schlegel. University Hospital Würzburg, Germany, University of Michigan and Ludwig-MaximiliansUniversität München, Germany. (465.5)

P95

Intestinal Mucosa Pro-Repair Properties of Macrophage Derived IL-10 Are Mediated by CREB Triggered Epithelial WISP-1 Signaling. M. Quiros, H. Nishio, P.A. Neumann, G. Leoni, V. Garcia-Hernandez, D. Siuda, M. Feng, G. Bernal, R. Hilgarth, H. Williams, J.C. Brazil, P.H. Dedhia, J. Spence, C.A. Parkos, T.L. Denning, A. Nusrat. University of Michigan, Universität München, Germany, Institute for Cardiovascular Prevention, Germany, Emory University and Georgia State University. (465.2) P96 Role of PMNs in Inhibition of DNA Repair and Induction of Genomic Instability. V. Butin-Israeli, L. Mehl, L. Lorraine Mascarenhas, R. Sumagin. Northwestern University. (178.5) P97 A Circadian Zip Code Determines Rhythmic Leukocyte Trafficking to Tissues. W. He, K. Kraus, D. Druzd, A. de Juan, L. Ince, C. Chen, C. Scheiermann. WalterBrendel-Zentrum für Experimentelle Medizin LudwigMaximilians-Universität München, Germany. (55.4) P98 Force-Induced α4 Integrin-Dependent Monocyte Adhesion Strengthening and F-Actin Remodeling Requires Actomyosin Contractility and Talin-1. H.M. Ibrahim, S.J. Hyduk, M.I. Cybulsky. Toronto General Hospital Research Institute, University Health Network, Canada and University of Toronto, Canada. (55.8) P99 Neutrophils Induce Pro-Angiogenic T Cells with a Regulatory Phenotype in Pregnancy. S. Nadkarni, J. Smith, A. Sferruzzi-Perri, M. Kishore, C. Mauro, D. Williams, F. Marelli-Berg, M. Perretti. Queen Mary, University of London, United Kingdom, Cambridge University, United Kingdom and University College London, United Kingdom. (469.10) P100 The CXCR3-LFA1-ICAM1 Axis Regulates T Cell Cardiotropism and Maladaptive Cardiac Remodeling in Heart Failure. A. Salvador, T. Nevers, F. Velazquez, M. Aronovitz, P. Alcaide. Tufts University, Universidad de Granada, Spain and Tufts Medical Center. (327.3) P101 Histamine Causes Endothelial Barrier Disruption via Ca2+-Mediated RhoA Activation and Enhanced Force Generation at Intercellular Junctions. L. Rotkopf, D. Kugelmann, E. Walter, M. Radeva, J. Waschke. Ludwig-Maximilians-Universität München, Germany. (978.1) P102 CD43 Syalomucin Contributes to Cardiac Inflammation and Fibrosis in Non-Ischemic Heart Failure. F. Velázquez, A. Salvador, T. Nevers, N. Ngwenyama, M. Aronovitz, R. Blanton, P. Alcaide. Tufts University and Tufts Medical Center. (59.2) P103 PAD4 Deficiency Limits Kidney Dysregulation in a Murine Model of Shock/Sepsis. B. Biron Girard, Y. Chen, C. Chung, J.B. Reichner, A. Ayala. Brown University/Rhode Island Hospital and Rhode Island Hospital. (657.16)

151

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Small Peptide Antagonists Derived Based on in Silico Analysis Block CXCL10-CXCR3 Signaling and Function on Cardiac Fibroblasts and Cardiomyocytes. L. Espinoza Ornelas, B.J. Lantonio, J. Jaynes, R. Bodnar, M.S. Willis, C.C. Yates. University of Pittsburgh, Tuskegee University and University of North Carolina at Chapel Hill. (984.1) P105 Identifying Key Domains in Endothelial IQGAP1 Critical for Leukocyte Transmigration. P. Dalal, D. Sullivan, W. Muller. Northwestern University. (657.10) P106 Reliable CD4 and CD8TCell Marker Immunohistochemistry on Formalin-Fixed and Histochoice-Fixed Paraffin Embedded Mouse Spleen. K.N. Bradshaw, J. WengRace, J.M. Ward, J.E. Rehg, J.A. Kovacs, A.S. Davis Kansas State University, Global VetPathology, St. Jude Children’s Research Hospital and National Institutes of Health Clinical Center. (979.5) P107 Detection of Phenotypic Differences in Alveolar Macrophages Using Ionized Calcium-Binding Adapter Molecule 1 Marker. D.K. Meyerholz, C.M. Hogan, R.M. Glanz, J.A. Goeken, M.R. Leidinger, G.K. Ofori-Amanfo, L. McQuillen, K.M. Donovan, S.C. Harwani, H.A. Flaherty. University of Iowa Carver College of Medicine, University of Southern California and Iowa State University. (656.20) P108 Sex, Age, and TNF Influence the Gut Microbiota in a Mouse Model of TNBS Colitis. A.J. Kozik. Purdue University. (657.12) P109 Lack of NF-κB-Inducing Kinase (NIK) Results in Eosinophilic Esophagitis (EoE) and Gastric Hyperplasia in Mice: Implications for Noncanonical NF-κB Signaling in Human EoE. K. Eden, D.K. McDaniel, B. Heid, I.C. Allen. Virginia Maryland College of Veterinary Medicine. (469.12) P110 Reverse Transcriptase Real Time PCR Detection of Rift Valley Fever Virus RNA in Formalin-Fixed, Paraffin-Embedded Tissues. D. Upreti, W.C. Wilson, J.A. Richt, A.S. Davis, J.D. Trujillo. Kansas State University, USDA and ARS. (658.5) P111 Evaluation of Fluorescence Microsphere Immunoassay for Antibody Detection to Rift Valley Fever Nucleocapsid Protein and Glycoproteins. I. Ragan, B. Faburay, D.S. McVey, J.A. Richt, A.S. Davis, R.R. Rowland, W.C. Wilson. Kansas State University and USDA ARS. (658.4)

152

P112 Immuno-Modulating and Anti-Viral Properties of Tulathromycin in Porcine Reproductive and Respiratory Syndrome. D.J. Desmonts de Lamache, R.D. Moges, R. Yates, N. McKenna, D.W. Morck, A.G. Buret University of Calgary, Canada. (984.6) P113 Molecular Analysis of the Blood-Tumor Barrier in Brain Metastasis from Breast Cancer. L. Lyle, R. Duchnowska, P. Lockman, C. Adkins, A. Shareef, E. Sechrest, E. Hua, D. Liewehr, S. Steinberg, W. Kloc, N. Nayyar, P. Brastianos, S. Patricia, B. Gril. National Cancer Institue, Purdue University, Military Institute of Medicine, Poland, West Virginia University, Copernicus Hospital Gdansk, Poland and Harvard Medical School. (808.1) P114 RGDSK Peptide Functionalized Helical Rosette Nanotubes (RGDSK-HRNs) Block Integrin αvβ3 and inhibit E. coli Adherence to Intestinal Porcine Epithelial 1 Cell Line (IPEC1) in Vitro. N. Le, C. Quach, G. Aulakh, V. Gerdts, H. Fenniri, B. Singh. Western College of Veterinary Medicine, University of Saskatchewan, Canada, Vaccine and Infectious Disease Organization—International Vaccine Centre (VIDO-InterVac), Canada, Northeastern University, Faculty of Veterinary Medicine and University of Calgary, Canada. (658.10) P115 Developing an in Vivo Model of Reinke’s Edema. A. Durkes, P. Sivasankar. Purdue University. (656.22) P116 Investigative Analysis of the Waste Impact in the Environmental by Necropsies in Rescued Sea Turtles (Chelonia mydas) in Ubatuba, São Paulo State, Brazil. J. Duarte, T.C. Hipolito, A.C. Tasaka, V.C. Hyodo, E. Mergulhao. UNIP, Brazil. (982.8) P117 SREBP-1c Increases the Hepatic Inflammatory Response in Dairy Cows with Fatty Liver Through ROS-Mediated NF-κB Pathway. X. Li, G. Liu. Jilin University, People’s Republic of China. (804.4) P118 Characterization of Immunodeficient Mouse Models. J. McClellan, R. Macasocal, T. Hare, M. Horn. Envigo. (807.14) P119 Investigating the Potential Role of North American Animals as Hosts for Zika Virus. I. Ragan, E. Blizzard, R. Bowen. Kansas State University and Colorado State University. (658.3)

TUESDAY PHARMACOLOGY

Pharmacology 473. JULIUS AXELROD AWARD IN PHARMACOLOGY LECTURE

475. SCIENCE AND GOVERNMENT: HOW TO MAKE A DIFFERENCE THROUGH ADVOCACY

Award Lecture

Symposium

Tue. 8:30 am—McCormick Place Convention Center, W470B

(Sponsored by: ASPET 2016 Washington Fellows) Tue. 9:30 am—McCormick Place Convention Center, W475

Cancer Biology

Chaired: A.C. Marshall and N.K. Patil

Cardiovascular Biology The Julius Axelrod Award is presented annually for significant contributions to understanding the biochemical mechanisms underlying the pharmacological actions of drugs and for contributions to mentoring other pharmacologists. The Award was established in 1991 to honor the memory of the eminent American pharmacologist who shaped the fields of neuroscience, drug metabolism, and biochemistry and who served as a mentor for numerous eminent pharmacologists around the world. This lecture runs from 8:30 am–9:20 am. 8:30 Introduction. 8:35 Lessons from Endogenously Expressed GPCRs: Nature Knows Best!. Paul Insel. Univ. of California, San Diego.

474. JULIUS AXELROD SYMPOSIUM: EVOLVING INSIGHTS REGARDING GPCRS: COMPARTMENTATION, SIGNALING AND CLINICAL UTILITY Symposium (Sponsored by: John V. Croker Fund) Tue. 9:30 am—McCormick Place Convention Center, W470B

Professional Development Education Science Policy This session runs from 9:30 am–12:00 pm. 9:30

Looking for a Few Good Fellows: The Critical Role of Early Career Scientists in Advocacy. Kenneth Thummel, Univ. of Washington, and Susanna Aguirre, ASPET. 9:45 From PhD to Policy: Advancing Your Career and Advocacy. Remy Brim. 10:15 Getting Involved Early: How Young Scientists Can Make a Difference. Debra Cooper. California Senate Office of Research. 10:45 Bridging the Gap for Drug Development. Dennis Marshall. Ferring Pharmaceuticals, Inc. 11:15 Finding Your Voice: How to be an Advocate for Science. Yvette Seger. FASEB. 11:45 Panel Discussion.

476. PERINATAL THERAPEUTICS AND THE PROGRAMMING OF ADULT CARDIOMETABOLIC DISEASE Symposium

Chaired: P.A. Insel

(Sponsored by: ASPET Division for Cardiovascular Pharmacology)

Cancer Biology Inflammation/Immunity

Tue. 9:30 am—McCormick Place Convention Center, W470A

Metabolism and Metabolic Disease

Chaired: S.L. Bourque and S. Goulopoulou

9:30 Introduction. Paul Insel. Univ. of California, San Diego. 9:35 Structure, Activation and Inhibition of Chemokine Receptors. Tracy Handel. Univ. of California, San Diego. 10:05 The Membrane-intracellular Organelle Interface: A Compartment for GPCR Regulation of Cellular Metabolism and Function. Hemal Patel. Univ. of California, San Diego. 10:35 cAMP Signaling Compartments: Adenylyl Cyclases as the Anchors. Rennolds Ostrom. Chapman University. 11:05 Beta-3 Adrenoceptor Agonists: A Case Study of Pharmacology in First-in-class GPCR Drug Discovery and Development. Martin Michel. Johannes Gutenberg University. 11:35 Panel Discussion.

Cardiovascular Pharmacology Drug Discovery and Development Translational and Clinical Pharmacology This session runs from 9:30 am–12:00 pm. 9:30

Epigenetics and the Developmental Origins of Obesity, Type 2 Diabetes, and Cardiovascular Disease: Known, Unknowns and Possibilities. Susan Ozanne. Univ. of Cambridge. 10:00 Gestational Diabetes and Fetal Programming of Metabolic Function: Mechanisms and Interventions. Vernon Dolinsky. Univ. of Manitoba.

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PHARMACOLOGY TUESDAY 10:30 Early Postnatal Interventions for the Sex-specific Programming of Cardiovascular Dysfunction by Prenatal Hypoxia. Sandra Davidge. University of Alberta. 11:00 The RAS as a Therapeutic Target for the Fetal Programming of Cardiovascular Disease. Karen Moritz. The Univ. of Queensland. 11:30 Gestational Exposure to Engineered Nanomaterials Effects Microvascular Health of Young Progeny. P.A. Stapleton. Rutgers University. (997.4) 11:45 Fetal Betamethasone Exposure Markedly Attenuates the Protein Expression of Angiotensin Converting Enzyme 2 but Not Dipeptidyl Peptidase 3 Within the Brain Dorsomedial Medulla of Adult Female Sheep. A.S. Hendricks, H.A. Shaltout, M.C. Chappell, D.I. Diz. Wake Forest School of Medicine. (997.6)

477. QUANTITATIVE SYSTEMS PHARMACOLOGY: APPLICATION TO CANCER DRUG DEVELOPMENT AND PERSONALIZED/ PRECISION MEDICINE Symposium (Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Tue. 9:30 am—McCormick Place Convention Center, W471A Chaired: J.L.S. Au and J.S.H. Lee Translational and Clinical Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. Application of QSP in Therapy Development: Intravesical Bladder Cancer Therapy as an Example. Jessie Au. Optimum Therapeutics LLC, Inst. of Quantitative Systems Pharmacology, Univ. of Oklahoma, Taipei Med Univ., The Ohio State Univ. 9:45 Current and Future Technologies NCI Supports in Oncology Drug Discovery and Development. Jerry Lee. National Cancer Institute. 10:05 Using Novel Quantitative Approach to Under Association Between the Biological Targets and Adverse Reactions for Tyrosine Kinase Inhibitors. Liang Zhao. US Food and Drug Administration. 10:25 Q&A. 10:40 Pharmacogenomics: One Piece of the Puzzle in Personalized and Precision Medicine. Stephen Eck. Astella Pharma. 11:00 Translational Bioinformatics Research in Drug Interaction and Its Application in the Precision Medicine. Lang Li. Indiana Univ. 11:20 A Quantitative Systems Pharmacology Approach to Antiangiogenic Therapy. Sukung Woo. Univ. of Oklahoma Health Sciences Center. 11:40 Q&A. 11:55 Wrap Up.

478. EMERGING TECHNOLOGIES FOR SELECTIVELY MODULATING THE TUMOR IMMUNE CONTEXTURE Symposium (Sponsored by: ASPET Division for Drug Discovery and Development) Tue. 9:30 am—McCormick Place Convention Center, W474A Chaired: S. Sengupta and A.A. Kulkarni Drug Discovery and Development Cancer Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. 9:30

Engineering Enhanced Cancer Vaccines. Darrell Irvine. Massachusetts Inst. Of Technology. 10:00 Supramolecular Therapeutics that Selectively Modulate the Tumor Immune Contexture. Shiladitya Sengupta. Harvard Medical School Medicine. 10:30 Targeting the Immune Cells for Anticancer Efficacy. Puja Sapra. Pfizer, Inc. 11:00 Imaging an Immunotherapy Response in Real-time. Ashish Kulkarni. Brigham and Women’s Hosp, Harvard Medical Sch. 11:30 Peptide-Based Targeted Delivery for Immune Modulation. Hongbo Pang. Burnham Institute. 11:58 Conclusion.

479. MUSHROOMING POTENTIAL OF PSYCHEDELICS AS THERAPEUTICS

9:30

154

Symposium (Sponsored by: ASPET Division for Behavioral Pharmacology) Tue. 9:30 am—McCormick Place Convention Center, W474B Chaired: W.E. Fantegrossi and R. Griffiths Behavioral Pharmacology Science Policy Neurobiology This session runs from 9:30 am–12:00 pm. 9:30

Animal Models of Hallucinogens and Serotonin 5-HT2A Receptor Neuropharmacology. Javier GonzalezMaeso. Virginia Commonwealth Univ. 10:00 Therapeutic Potential of 5-HT2A Agonists for Psychiatric Disorders: Are Psychedelic Effects Necessary? Clinton Canal. Northeastern Univ. 10:30 Human Psychopharmacology of Hallucinogens. Theresa Carbonaro. Johns Hopkins University Sch. Of Med. 11:00 Hallucinogens as Novel Psychotherapeutics. Roland Griffiths. Johns Hopkins Univ. Sch. of Med. 11:30 Panel Discussion. William Fantegrossi. Univ. of Arkansas for Medical Sciences.

TUESDAY PHARMACOLOGY

480. DAVID LEHR RESEARCH AWARD LECTURE Award Lecture

482. DIVISION FOR NEUROPHARMACOLOGY POSTDOCTORAL SCIENTIST AWARD FINALISTS

Tue. 2:00 pm—McCormick Place Convention Center, W470B

Division Oral Session (Sponsored by: ASPET Division for Neuropharmacology)

The David Lehr Research Award is intended to extend funding for preclinical or clinical research directed towards improving human health. The inaugural recipient of the award in 2015 will present his research.

Tue. 3:00 pm—McCormick Place Convention Center, W470A Chaired: M.W. Wood and B. Greenwood-Van Meerveld

This lecture runs from 2:00 pm–2:50 pm. 2:00 Introduction. David Sibley. ASPET. 2:05 Adenosine-Regulated Glutamate Signaling in NeuronGlia Interaction and Alcoholism. Doo-Sup Choi. Mayo Clinic College of Medicine.

Neuropharmacology Neurobiology This session runs from 3:00 pm–5:30 pm. 3:00

481. SURMOUNTING THE INSURMOUNTABLE: OBSTACLES IN DRUG DISCOVERY AND DEVELOPMENT—REAL WORLD CASE STUDIES Symposium (Cosponsored by: ASPET BIG IDEAS Initiative and ASPET Division for Drug Discovery and Development)

3:15

Tue. 3:00 pm—McCormick Place Convention Center, W475 Chaired: K. He and P.F. Hollenberg

3:30

Drug Discovery and Development Drug Metabolism

3:45

Inflammation/Immunity A product of the ASPET BIG IDEAS initiative, this workshop is a forum for pharmacological experts to present “real world” stories recounting when, in their own experience, insurmountable problems arose and explaining how critical thinking and problemsolving skills were used for the drug development process to continue.

4:00

This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Sustiva: A Rescue from Death Due to Nonclinical Toxicity. Gerald Miwa. Univ. of North Carolina, Eshelman Sch. of Pharmacy. 3:40 Challenges in the Discovery and Development of Vorapaxar, A Novel Antiplatelet Drug. Madhu Chintala. Johnson & Johnson. 4:15 Empagliflozin: Sex, Species, and Tissue-specific Metabolism. Mitchell Taub. Boehringer Ingelheim Pharmaceuticals. 4:50 Apixaban: How Volume of Distribution Became Critical in Optimizing Efficacy and Minimizing Toxicity. Kan He. Biotranex, LLC. 5:25 Conclusion. Paul Hollenberg. Univ. of Michigan.

4:15

4:30

Estrous Cycle-Dependent Alterations in Cocaine Affinity at the Dopamine Transporter Underlie Enhanced Cocaine Reward in Females. E.S. Calipari, B. Juarez, C. Morel, D.M. Walker, M. Cahill, E. Riberio, K. Deisseroth, M. Han, E.J. Neslter. Icahn School of Medicine at Mount Sinai and Stanford University. (989.6) Cortical Circuit Dynamics During Punishment-Resistant Alcohol Drinking. C.A. Siciliano, Y. Leow, C. Vander Weele, E. Kimchi, D. Xu, X. Chen, K.M. Tye. Massachusetts Institute of Technology. (661.6) Altered Kisspeptin Responsiveness in Bmal1 Knockout Females. K.J. Tonsfeldt, E. Schoeller, L. Brusman, P. Mellon. University of California San Diego. (989.7) The Neuroprotective Role of Myeloid Zinc Finger-1 and Specificity Protein 1 During Treatment with Leukemia Inhibitory Factor. S. Davis, L. Collier, J. Fazal, M. Britton, C. Leonardo, C. Ajmo, K. Pennypacker. University of Kentucky and University of South Florida. (815.6) A G Protein-Biased Ligand of the Kappa Opioid Receptor Is Antinociceptive and Antipruritic but Does Not Cause Sedation or Dysphoria. T.F. Brust, J. Morgenweck, S.A. Kim, J.H. Rose, J.L. Locke, C.L. Schmid, L. Zhou, E.L. Stahl, M.D. Cameron, S.M. Scarry, J. Aubé, S.R. Jones, T.J. Martin, L.M. Bohn. The Scripps Research Institute, Wake Forest School of Medicine and University of North Carolina at Chapel Hill. (992.4) Organic Cation Transporter 3 Upregulation in Serotonin Transporter Deficient Mice Potentiates EthanolInduced Serotonin Clearance Impairments. T.L. Gilman, R.E. Horton, N.L. Baganz, S.R. Alvarado, L.C. Daws. University of Texas Health Science Center at San Antonio. (661.4) Pharmacologic Inhibition and Genetic Elimination of p38α MAPK Normalizes Serotonergic System Alterations and Social Behavior Deficits in the SERT Ala56 Mouse Model of Autism Spectrum Disorder. M.J. Robson, M.A. Quinlan, J. VeenstraVanderWeele, D. Watterson, R.D. Blakely. Florida Atlantic University, Vanderbilt University, Columbia University and Northwestern University. (813.10)

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PHARMACOLOGY TUESDAY 4:45

5:00

5:15

Endogenous Melatonin Decreases Place Preference for Methamphetamine Through a Learning and Memory Independent Mechanism in C57BL/6 Mice. S.J. Clough, T. Kasahara, K.M. Veros, R.L. Hudson, M.L. Dubocovich. Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY and RIKEN Brain Science Institute, Japan. (662.11) Blockade of a Novel Neuropeptide Receptor System, BigLEN-GPR171, Reduces Adverse Effects of Prolonged Morphine Administration. E.N. Bobeck, D. Pena, I. Gomes, A. Fakira, L. Devi. Icahn School of Medicine at Mount Sinai and University of São Paulo, Brazil. (985.8) Enhanced Mitochondrial Biogenesis for the Treatment of Spinal Cord Injury. N.E. Scholpa, A. Narang, W. Wang, D. Corum, S. Tomlinson, R.G. Schnellmann. University of Arizona and Medical University of South Carolina. (815.13)

483. DIVISION FOR TOXICOLOGY—IN UTERO AND NEONATAL EXPOSURE TO ENVIRONMENTAL AGENTS Division Symposium (Sponsored by: ASPET Division for Toxicology) Tue. 3:00 pm—McCormick Place Convention Center, W470B Chaired: M. Valentovic Toxicology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Presentation of Division for Toxicology Career Award. Lauren Aleksunes. Rutgers Univ. 3:10 Prenatal Exposure Resulting in PAH-DNA Adducts in Umbilical Cord Blood. Monica Valentovic. Marshall Univ. School of Medicine. 3:30 Human Prenatal Exposure to Essential and Toxic Elements. Jesse Cottrell. Marshall Univ. School of Med./Univ. of Mississippi Med. Ctr. 3:50 Age-Related Changes in the Disposition of Pyrethroid Insecticides. Catherine White. Univ. of Georgia. 4:23 Microvascular Ramifications of Maternal Nanomaterial Inhalation: Uterine and Fetal Perspectives. Tim Nurkiewicz. West Virginia Univ. 4:56 Gestational Nanomaterial Exposures: The Next Generation. Phoebe Stapleton. Rutgers Univ. School of Pharmacy. 5:29 Wrap Up.

156

484. DIVISION FOR CANCER PHARMACOLOGY— YOUNG INVESTIGATORS SYMPOSIUM Division Oral Session (Sponsored by: ASPET Division for Cancer Pharmacology) Tue. 3:00 pm—McCormick Place Convention Center, W474A Chaired: S.P. Cole and J.C. Yalowich Cancer Pharmacology Cancer Biology This session runs from 3:00 pm–5:30 pm. 3:00

Lipidomic Profiling Identifies Cytochrome P450 as a Therapeutic Target for Colitis-Associated Colorectal Cancer. W. Wang, J. Yang, M. Song, D. Wan, H. Yang, K. Sanidad, B.D. Hammock, H. Xiao, G. Zhang. University of Massachusetts, University of California at Davis. (823.5) 3:20 The Interaction of GIV with Galpha-I Is a Druggable Protein-Protein Interaction. V. DiGiacomo, A.I. de Opakua, N. Merino, J.B. Blanco-Canosa, F.J. Blanco, M. Garcia-Marcos. Boston University School of Medicine, CIC-BioGune, Spain and Institute for Research in Biomedicine, Spain. (823.6) 3:40 A Constitutive Androstane Receptor (CAR) Inhibitor CINPA1 as a Tool to Understand Receptor Structure and Function. M.T. Cherian, S.C. Chai, M.A. Casal, T. Chen. St Jude Children’s Research Hospital and University of Pittsburgh. (671.14) 4:00 Break. 4:20 Oncolytic Adenovirus Expressing IFN-α Synergistically Potentiates Chemotherapy, Radiation, and Chemoradiation in Pancreatic Cancer Cells. A.O. Salzwedel, C. LaRocca, J. Han, K. Aoki, J. Davydova, M. Yamamoto. University of Minnesota, National Cancer Center Research Institute, Hachioji, Japan. (1064.6) 4:40 cAMP-Phosphodiesterase PDE4D as a Target for Colon Cancer Therapy. A. Boyd, G. Baskar, T. Petty, A. Keeton, G. Piazza, W. Richter. University of South Alabama. (671.11) 5:00 Non-Cannonical Notch Signaling Pathways Regulate Breast Cancer Stem-Like Cells Function in Triple Negative Breast Cancer. F. Hossain, C. Sorrentino, A. Bilyeu, J. Crabtree, A. Pannuti, T. Golde, B. Osborne, L. Miele. LSUHSC, University of Florida and Umass Amherst. (671.6) 5:20 Wrap Up.

TUESDAY PHARMACOLOGY

485. DIVISION FOR BEHAVIORAL PHARMACOLOGY— TEAM SCIENCE FORUM: SCIENTIST CROSSTALK ON CHEMISTRY AND BEHAVIOR Division Symposium (Sponsored by: ASPET Division for Behavioral Pharmacology) Tue. 3:00 pm—McCormick Place Convention Center, W474B Chaired: E. Jutkiewicz and B. Blough Behavioral Pharmacology Professional Development The session will focus on the highly collaborative interactions between medicinal chemists and behavioral pharmacologists in the development and investigation of novel therapeutics. Pairs of speakers will describe findings ranging from chemical design and synthesis to in vivo evaluation of a single class of compounds. Importantly, these teams will demonstrate how scientists from these different fields communicate and educate each other, emphasizing the challenges and successes of these important scientific relationships. This session runs from 3:00 pm–5:30 pm. 3:00

3:50

4:40

Pair 1: Development of GlyT-1 Inhibitors for the Treatment of Psychiatric Disorders. Peter Guzzo, ConSynance Therapeutics, Inc., and Nicholas Moore, Brains-Online. Pair 2: Designing Mixed Efficacy Opioid Ligands with Improved Analgesic Profiles. Henry Mosberg, Univ. of Michigan, and Emily Jutkiewicz, Univ. of Michigan Med. Sch. Pair 3: Optimizing in Vivo Pharmacology of ShortActing Cannabinoid Ligands. Alex Makriyannis, Northeastern Univ., and Carol Paronis, McLean Hosp., Harvard Univ. Med. Sch.

3:30

Inhibition of Neuropilin 1 Signaling in Glioma Associated Macrophages and Microglia Slows Tumor Progression. J.T. Miyauchi, D. Chen, M. Choi, K. Shroyer, D. Selwood, S. Tsirka. Stony Brook University and University College London, United Kingdom. (1063.6) 3:50 Ursolic Acid from Shea Butter Tree (Vitellaria paradoxa) Leaf Extract Synergizes with β-Lactams Against Methicillin-Resistant Staphylococcus aureus. L. Catteau, J. Olson, F. Van Bambeke, J. Leclercq, V. Nizet. Université Catholique de Louvain (UCL), Belgium and University of California San Diego (UCSD). (1000.5) 4:10 11/14-Oxy-DPA, the 12-LOX Derived Metabolites of DPA, Inhibit Platelet Activation Through the cGMPPKG Signaling Pathway. J. Yeung, N. Edokobi, M. Hawley, D. Craven, C. Li, T.R. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. (675.5) 4:30 Treatment with Anti-PD-L1 Antibody Improves Antimicrobial Immunity During Burn Wound Sepsis. N. Patil, L. Luan, E.R. Sherwood. Vanderbilt University Medical Center. (1001.5) 4:50 Drugging the Gut Microbiome for the Treatment of Alcohol-Induced Liver Injury. R.N. Helsley, R.C. Schugar, D. Ferguson, A.D. Gromovsky, C. Neumann, Z. Wang, D. Allende, L.E. Nagy, S.L. Hazen, J.M. Brown. Cleveland Clinic Foundation. (1068.7) 5:10 Awards.

487. DIVISION FOR TRANSLATIONAL AND CLINICAL PHARMACOLOGY— EARLY CAREER FACULTY SHOWCASE Division Oral Session (Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Tue. 5:30 pm— McCormick Place Convention Center, W471A

486. DIVISION FOR TRANSLATIONAL AND CLINICAL PHARMACOLOGY—YOUNG INVESTIGATOR AWARDS PLATFORM SESSION Division Oral Session (Sponsored by: ASPET Division for Translational and Clinical Pharmacology)

Chaired: P.J. Hornby Translational and Clinical Pharmacology This showcase runs from 5:30 pm–6:00 pm. 5:30

Tue. 3:00 pm—McCormick Place Convention Center, W471A Translational and Clinical Pharmacology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:10 Novel Characterization of Docohexanoic Acid and Its 12-LOX Products, 11-HDHE and 14-HDHE on Human Blood Platelets. M. Hawley, D.D. Craven, N. Edokobi, T. Holman, M. Holinstat. University of Michigan Medical School and University of CaliforniaSanta Cruz. (675.4)

5:45

Discontinuation of Chronic RAAS Inhibitor Therapy at Time of Contrast Media Administration Reduces Degree of Kidney Injury in an Animal Model. D.A. Lauver, J.I. Parsh, H.S. Gurm. Michigan State University and University of Michigan Health System (998.2) High-Calorie Diet Induces Vascular and Hemodynamic Abnormalities in Absence of Change in Blood Glucose or Insulin Levels: Modulation by Oral AntiHyperglycemic Drugs. A. El-Yazbi, M. El-Khatib, M. Fouda, F. Sleiman, E. Saad, H. Fouad, A. Eid. Alexandria University, Egypt and American University of Beirut, Lebanon (1068.3)

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PHYSIOLOGY TUESDAY

Physiology 488. APS PRESIDENT’S SYMPOSIUM SERIES: RESEARCH ADVANCES IN SEX/GENDER AND DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES

8:30

DEVELOPMENTAL PROGRAMMING OF DISEASES

8:45

Symposium

9:00

President’s Symposium Series Tue. 10:30 am—McCormick Place Convention Center, W375A

9:15

Chaired: B. Alexander Sex Differences and Women’s Health

9:30

Developmental Programming Hypertension 10:30 An Overview of the Concept of Developmental Programming. Kent Thornburg. Oregon Hlth. and Sci. Univ. 11:00 Actions of Bisphenol A (BPA) and Chemical Used in BPAFree Products on the Reproductive Neuroendocrine System during Early Development. Nancy Wayne. UCLA Sch. of Med. 11:30 The Benjamin Button Approach to Understanding the Developmental Origns of Hypertension. Kate Denton. Monash Univ. 12:00 Epigenetic Consequences of Adverse Fetal Life. Torsten Plosch. Univ. of Groningen.

9:45

490. ATTTACHING PHYSIOLOGY TO THE GENOME: SPOTLIGHT ON CARDIOVASCULAR GENETICS

489. ADVANCES IN RENAL PHYSIOLOGY II

Symposium

Featured Topic

(Cosponsored by: American Society for Human Genetics)

(Sponsored by: Renal Section)

Tue. 8:00 am—McCormick Place Convention Center, W190A

Tue. 8:00 am—McCormick Place Convention Center, W192C Chaired: E. Inscho and A. Polichnowski

Chaired: E. Davis and B. Joe 8:00

Salt Inflammation/Immunity

8:25

Hypertension 8:00

8:15

158

Nox 4 Null Mutation Attenuates Podocyte Calcium Regulation Dysfunction and Kidney Damage in Streptozotocin-Treated Dahl Salt-Sensitive Rats. G. Blass, D. Ilatovskaya, K. Winsor, V. Levchenko, O. Palygin, A.W. Cowley Jr., A. Staruschenko. Medical College of Wisconsin. (716.9) Imaging Renin Granule Exocytosis in Juxtaglomerular Cells by Total Internal Reflection (TIRF) Microscopy. M. Mendez. Henry Ford Hospital. (701.3) A New View of Macula Densa Cell Microanatomy. G. Gyarmati, J. Moon, A. Riquier Brison, J. PetiPeterdi. University of Southern California. (701.12) Administration of Tempol Improves Renal Autoregulation in Ischemia-Reperfusion Induced Acute Kidney Injury. Z. Guan, C. Ryoo, E.W. Inscho. University of Alabama at Birmingham. (1030.6) Tempol Prevents the Enhancement of Angiotensin II Contractions of Afferent Arterioles from Mouse with Reduced Renal Mass. L. Li, E. Lai, Z. Luo, K.K. Griendling, W.K. Taylor, A. Wellsten, W. Welch, C.S. Wilcox. Georgetown University, Zhejiang University, People’s Republic of China, and Emory University. (698.7) Susceptibility to Pressure-Induced Renal Injury in DOCA-Salt vs. Angiotensin II Hypertensive Rats. A.J. Polichnowski, K. Griffin, P. Sethupathi, V. Patel, M. Patel, M. Picken, G. Williamson, A. Bidani. East Tennessee State University, Hines VA Hospital and Loyola University Chicago and Illinois Institute of Technology. (701.2)

Transcriptional Regulation and Therapeutic Targeting of P2X7 Receptors in Diabetic Nephropathy. R.I. Menzies, J.W. Booth, J.J. Mullins, M.A. Bailey, F.W. Tam, J.T. Norman, R.J. Unwin. University of Edinburgh, United Kingdom, UCL, United Kingdom and Imperial College London, United Kingdom. (716.11) Novel CRISPR/Cas9 Mouse Knock-In Model Containing an Alpha-Actinin 4 Mutation Associated with Focal Segmental Glomerulosclerosis Recapitulated Human Kidney Injury and Provides Insight Into How Aberrations in Cytoskeleton Lead to Podocyte Dysfunction. D. Feng, R. Krishnan, A. Benjamin, M.R. Pollak. Beth Israel Deaconess Medical Center and Harvard Medical School. (1031.1)

8:50 9:15 9:40

Characterizing Functional Regulatory Variants in iPSCderived Human Cardiomyocytes. Kelly Frazer. UCSD Sch. of Med. From Genes to Function: Mechanistic Studies of Cardiometabolic Disorders in Mammalian Models. John Hall. Univ. of Mississippi Med. Ctr. Modeling Cardiovascular Disease in Zebrafish for Pathway Annotation and Drug Discovery. Calum MacRae. Brigham and Women’s Hosp. Leveraging GWA’s and Sequence Data from the Clinic in Basic Research. Howard Jacob. HudsonAlpha Inst. for Biotech. Panel Discussion.

TUESDAY PHYSIOLOGY

491. BRAIN SECRETS REVEALED BY OPTOGENETICS/ CHEMOGENETICS APPROACHES

493. ION CHANNELS AND TRANSPORTERS IN HEALTH AND DISEASE Featured Topic

Symposium

(Sponsored by: Cell and Molecular Physiology Section)

(Sponsored by: Neural Control and Autonomic Regulation Section)

Tue. 8:00 am—McCormick Place Convention Center, W192A

Tue. 8:00 am—McCormick Place Convention Center, W196C

Chaired: K.L. Hamilton and E. Rodrigues Ion Channels and Transporters

Chaired: K. Rahmouni and A. De Kloet Neurophysiology Neurobiology 8:00 8:30 9:00

9:30

The C1 Cells Mediate the Protective Effect of Psychological Stress against Ischemic/Reperfusion Renal Injury. Patrice Guyenet. University of Virginia. Dissection of the Role of the Lateral Hypothalamic Neurons in Physiological Regulation. Huxing Cui. University of Iowa. Illumination of Brain Angiotensin Receptor Circuits Reveal an Access Point for Neuroendocrine and Autonomic Control. Annette De Kloet. University of Florida. Oxytocin Activation: A New Target for Improving Autonomic Balance to the Heart. David Mendelowitz. The George Washington University.

492. EXERCISE TRAINING VERSUS METFORMIN FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES Symposium (Sponsored by: Environmental and Exercise Physiology Section) Tue. 8:00 am—McCormick Place Convention Center, W190B Chaired: W.G. Schrage and N. Jenkins Muscle Metabolism 8:00 Exercise and Metformin Interactions on Insulin Sensitivity and Glucose Metabolism. Barry Braun. Colorado State University. 8:30 Exercise and Metformin Interactions on CVD Risk Factors and Inflammation. Steve Malin. University of Virginia. 9:00 Exercise and Metformin Effects on Adipose Tissue and Vasculature. Nathan Jenkins. University of Georgia. 9:30 Exercise Training versus Metformin on NAFLD-Related Outcomes and Hepatic Lipid Metabolism. Scott Rector. University of Missouri-Columbia.

8:00

How the Thick Ascending Limb Works: An Update. Jens Leipziger. Aarhus Univ. 8:30 NKCC Regulates Circadian Rhythm via the ChlorideSensing WNK Kinase. A. Rodan, J. Schellinger, Q. Sun, A. Rothenfluh. University of Utah and University of Texas Southwestern. (1007.12) 8:45 Peter K. Lauf Travel Award Winner Abstract #2 for the Ohio Physiological Society, November 2016. N. Weisleder, D. Halm. Ohio State University Wexner Medical Center and Wright State University Boonshoft School of Medicine. (1007.2) 9:00 Calcium Oxalate (CaOx) Crystal Adhesion/ Agglomeration Dependence of CLC-5 Expression in Renal Epithelial Cells. R. Lorsung, P.C. Harris, J.C. Lieske, M. Chang. Mayo Clinic College of Medicine, University of Minnesota and Twin Cities. (1007.6) 9:15 Reduced Expression of Down-Regulated in Adenoma (DRA) in Murine Enteroid-Derived Monolayers Following Infection with Salmonella. R.R. Jayaratne, B. Lee, E. Lim, K. Barrett, S. Das University of California, San Diego, Korea University, Republic of Korea. (1007.15) 9:30 Functional Studies of TRPM7 —A Candidate Gene for Stillbirth? J. Cartwright, Q. Aziz, S. Harmer, A. Tinker, P. Munroe. Queen Mary University of London, United Kingdom. (1007.21) 9:45 Overexpression of SERCA2a Alters Endoplasmic Reticulum Ca2+ Handling in WKY but Not SHR Cardiac Sympathetic Neurons. A Role for Altered Intracellular Ca2+ Handling in Hypertensive Sympathoexcitation? J. Shanks, N. Herring, D. Li, E. Johnson, D.J. Paterson. Oxford University, United Kingdom and UNMC. (1007.19)

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494. AUTOPHAGY: DRIVER OF MICROBIOME COMPOSITION AND INTESTINAL HOMEOSTASIS

495. NEUROGLIAL INTERACTIONS IN HEALTH AND DISEASE Featured Topic

Featured Topic

(Sponsored by: CNS Section)

(Sponsored by: GI and Liver Physiology Section)

Tue. 8:00 am—McCormick Place Convention Center, W193

Tue. 8:00 am—McCormick Place Convention Center, W194B

Chaired: B. Gulbransen Inflammation/Immunity

Chaired: A. Theiss and J. Sun

Neurophysiology

Microbiome Inflammation/Immunity 8:00

8:15

8:30

8:45

9:00

9:15

9:30

160

Lactobacillus reuteri Modulates Dendritic Cells and the Immune Response in Vitro and in Vivo. M.A. Engevik, B.P. Ganesh, C. Visuthranukul, J. Versalovic. Baylor College of Medicine, Texas Children’s Hospital and King Chulalongkorn Memorial Hospital, Thailand. (1041.1) IMP1 Plays a Protective Role in LIN28B-Associated Intestinal Tumorigenesis by Regulating ER Stress and Cell Junction Assembly. P. Chatterji, K. Hamilton, S. Andres, S. Foley, R. Mizuno, A. Castells, M. Cuatrecasas, L. Simon, B. Gregory, B. Madison, A. Rustgi. University of Pennsylvania, IDIBAPS, Spain, University of Barcelona, Spain and Washington University. (1041.2) Autophagy Controls Epithelial Proteolytic Homeostasis of the Intestinal Mucosa. N. Vergnolle, N. Sola Tapias, C. Deraison, C. Blanpied, A. Edir, D. Gilles, B. Chrystelle, F. Barreau. Inserm U-1220, France. (1041.3) Lactic Acid Bacteria Isolated from Korean Kimchi Modulate the Vitamin D Receptor-Autophagy Signaling Pathways. M. Shang, Y. Zhang, R. Lu, Y. Jiao, Y. Xia, C. Kim, S. Kang, J. Sun. Sun Yat-sen University, People’s Republic of China, University of Illinois at Chicago, Dankook University, Republic of Korea, and Georgia State University. (1041.4) Mitophagy Regulation After Diet and Exercise in NonAlcoholic Fatty Liver Disease. M.E. Rosa-Caldwell, M. Harris, J.L. Brown, D.E. Lee, K. Poole, A. Seija, L.A. Brown, R.A. Perry; Jr., T.A. Washington, J.S. Wooten, N.P. Greene. University of Arkansas and Southern Illinois University Edwardsville. (1041.5) The Effect of a Western Diet on Hepatic Autophagy in Age Accelerated SAMP8 Mice. M.P. Harris, M.L. Schaller, D. Umbaugh, K. Sandoval, K.A. Witt, J.S. Wooten. Southern Illinois University Edwardsville. (1041.6) Autophagy and ER Stress in the Pathogenesis of Inflammatory Bowel Diseases. Richard Blumberg. Brigham and Women’s Hospital.

Neurobiology 8:00 8:30

8:45

9:00

9:15 9:30

9:45

Regulation of CNS Inflammation. Francisco Quintana. Brigham and Women’s Hospital. High-Fat Diet Induced Modulation of Glutamatergic Currents in Neurons of the Dorsal Motor Nucleus of the Vagus. C.E. Clyburn, K.N. Browning. Penn State Hershey. (1010.1) Defective Microglia Alters Respiratory Control and Mitochondrial Function in Mice. J. Rousseau, S. Laouafa, M. Tremblay, V. Joseph, R. Kinkead. IUCPQ, Université Laval, Canada, CNRS, UMR 5023-LEHNA, Université Claude-Bernard Lyon1, France, CRCHUQ and Université Laval, Canada. (1010.2) Microglia Promote Age-Dependent Post-Synaptic GluR2 Insertion in the Nucleus Tractus Solitarii Following Neonatal Acute Lung Injury. D.G. Litvin, C.B. Smith, F.J. Jacono. Case Western Reserve University and Louis Stokes Cleveland VA Medical Center. (1010.3) Enteric Glial Cells Acutely Regulate Secretomotor Function in the Mouse Colon. V. Grubisic, B.D. Gulbransen. Michigan State University. (1010.6) Maternal High Fat Diet Induces Myenteric Neuronal Loss and Upregulates Myenteric Glia Prior the Development of Obesity or Inflammation. C. McMenamin, K. Browning. Penn State College of Medicine. (1010.7) Auto-Immunity Targeting the Enteric Nervous System May Cause Constipation in Multiple Sclerosis. E.T. Spear, M.M. Haag, B. Lavoie, A. Applebee, C. Teuscher, G.M. Mawe. University of Vermont. (1010.8)

TUESDAY PHYSIOLOGY

496. EMBRACING THE HETEROGENEITY OF LUNG INJURY: A BEDSIDE TO BENCH TO BEDSIDE PERSPECTIVE

498. NOVEL INSIGHTS IN VASCULAR PATHOPHYSIOLOGY Featured Topic

Symposium

(Sponsored by: Cardiovascular Section)

(Sponsored by: Respiration Section)

Tue. 8:00 am—McCormick Place Convention Center, W196A

Tue. 8:00 am—McCormick Place Convention Center, W196B Chaired: S. Dudek and C. Shaver

Chaired: B. Isakson and P. Bagher 8:00

Ion Channels and Transporters Injury Repair and Regeneration

8:30

Inflammation/Immunity 8:00 8:25 8:45 9:05 9:25

Not a Single Disease State: Molecular Subphenotypes of Lung Injury in Human Trials. Carolyn Calfee. University of California San Francisco. Insult-Specific Glycobiology Signatures of Critical Illness: Impact on Lung Injury. Eric Schmidt. University of Colorado. Distinct Endothelial Responses to Lung Injury Insults: A Role for Apoptosis. Mahendra Damarla. Johns Hopkins University. Distinct Roles of Tissue Factor in Direct and Indirect Acute Lung Injury. Julie Bastarache. Vanderbilt University. An Individualized Approach to ARDS: Where Do We Go from Here? Steven Dudek. University of Illinois Chicago.

497. DEVELOPMENTAL PROGRAMMING OF VERTEBRATE HEALTH AND DISEASE BY HYPOXIA

8:45

9:00

9:15

Symposium (Sponsored by: Comparative & Evolutionary Physiology Section)

9:30

Tue. 8:00 am—McCormick Place Convention Center, W192B Chaired: G. Galli 8:00 8:30 9:00 9:30

Heart Disease Links to Fetal Hypoxia in Mammals: An Intergenerational Perspective. Dino Giussani. Univ. of Cambridge. Hypoxic Developmental Programming of Cardiovascular Function in Avian Models. Isa Lindgre. Oregon Health and Science University. Analyzing the Effects of Hypoxia on Fish Cardiovascular Development. Brian Bagatto. University Akron. Hypoxic Programming of Fetal Sheep Coronary Development. Sonnet Jonker. Oregon Health and Science University.

9:45

Revisiting Vascular Mineralocorticoid Receptors in the Coronary Circulation. Shawn Bender. University of Missouri. Characterization of Transendothelial Insulin Efflux as a Barrier to Insulin Action in Vivo. I.M. Williams, F.A. Valenzuela, A.R. Mezo, J.D. Young, K.S. Wells, D.H. Wasserman. Vanderbilt University and Lilly Research Laboratories. (1015.26) Smooth Muscle-Specific Deletion of Cullin-3 Causes Severe Early Onset Hypertension. L.N. Agbor, A.R. Nair, J. Wu, D.R. Davis, H.L. Keen, F.W. Quelle, J.A. McCormick, J.D. Singer, C.D. Sigmund. University of Iowa, Oregon Health and Science University and Portland State University. (1015.7) A Novel Functional Variant of nNOS Mediates Anoxic Injury in Brain Microvascular Endothelial Cells via Mitochondrial Superoxide Generation. V.N. Sure, A.L. Chen, N.R. Peterson, N.P. Jain, I. Rutkai, I. Merdzo, D.W. Busija, P.V. Katakam. Tulane University School of Medicine. (1015.34) Depletion of Caveolin-1 in Lung Vasculature and Increase in Caveolin-1 Positive Circulating Extracellular Vesicles as Early Biomarkers of Endothelial Injury. S. Santos Oliveira, M. Castellon, R.F. Machado, M.H. Elliott, M.G. Bonini, R.D. Minshall. University of Illinois at Chicago and University of Oklahoma Health Sciences Center. (1015.25) Impaired Perivascular Nerve Function of Mesenteric Arteries in a Murine Model of Inflammatory Bowel Disease. E.M. Boerman, M.L. Hart, C.L. Franklin, S.S. Segal. University of Missouri and Dalton Cardiovascular Center. (1015.5) Loss of Endothelial Fto Is Protective Against Metabolic Disease. N. Krüger, L.A. Biwer, M.E. Good, U. Rüther, B.E. Isakson. Heinrich Heine University of Düsseldorf, Germany, Robert M Berne Cardiovascular Research Center, University of Virginia and University of Virginia. (1015.15)

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499. SEX, STRESS, AND EPIGENETIC CONTRIBUTIONS IN AUTONOMIC REGULATION

500. MECHANISMS AND INFLUENCES ON CELL SIGNALING

Featured Topic

Featured Topic

(Sponsored by: Neural Control and Autonomic Regulation Section)

(Sponsored by: Cell and Molecular Physiology Section) Tue. 10:30 am—McCormick Place Convention Center, W194B

Tue. 10:30 am—McCormick Place Convention Center, W193

Chaired: R. Worrell

Chaired: S. Sriramula Neurophysiology Genetics, Epigenetics, MicroRNA Neurobiology 10:30 Epigenetic Regulation of Redox State Contributes to Cardio-Respiratory Pathologies in a Rodent Model of Sleep Apnea. Nanduri Prabhakar. University of Chicago. 11:00 Prenatal Exposure to Mild High Fat Diet Paradoxically Leads to Improvement in Cardio-Metabolic Function in the Offspring. S. Mukerjee, Y. Zhu, J. Zhao, A. Zsombok, E. Lazartigues. LSUHSC, University of Florida and Tulane University. (1057.2) 11:15 Acute Inhibition of HDACs After MI Leads to Low Inflammatory Profile: Implications for Post-MI Angiogenesis. S. Veeranki, S.C. Tyagi. University of Louisville. (1057.1) 11:30 Presence of an Inhibitory Glycinergic Current in Dorsal Motor Nucleus of the Vagus Neurons Regulating Gastric Functions in Offspring of Maternal High Fat Diet Rats. C. McMenamin, R. Travagli, K. Browning. Penn State College of Medicine. (864.2) 11:45 Glutamatergic Neurons in the Dorsal Hypothalamic Area Dissociate Thermogenesis from Heat Conserving Pathways During Stress Responses. N.L. Machado, S. Abbott, P. Fuller, M. Fontes, C. Saper. Beth Israel Deaconess Medical Center—Harvard Medical School, Heart Research Institute, Sydney and Federal University of Minas Gerais, Brazil. (866.1) 12:00 Aerobic Fitness Influences Autonomic Support of Blood Pressure in Premenopausal, but Not Postmenopausal Women. S.E. Baker, J.K. Limberg, W.T. Nicholson, T.B. Curry, J.N. Barnes, M.J. Joyner. Mayo Clinic and University of Wisconsin. (1056.4) 12:15 Hypertensive Young Adult Female Obese Zucker Rats (OZR) Do Not Develop the Impaired Baroreflexes or Reduced Activation of the NTS Observed in Male OZR. P. Chaudhary, G. Fu, A. Schreihofer. UNT Health Science Center. (1056.6)

Microbiome 10:30

Defining the Regulatory Role of Lipid Raft Microdomains During T Cell Receptor Activation. C.C. Osigwe, A.D. Levine. Case Western Reserve University. (1005.2) 10:45 ATP and Extracellular Calcium Regulates Differentially the Phagocytosis of S. aureus and C. glabrata by Macrophages. G. Pérez, C. Hernandez-Silva, J. Arreola, P. Pérez-Cornejo. UASLP, Mexico. (880.8) 11:00 The Host Engulfment Pathway in Enteroids Is Linked to Intestinal Inflammation Following Bacterial Infection. S. Das, E. Lim, K. Suarez, P.B. Ernst, K.E. Barrett. University of California San Diego. (695.2) 11:15 Show Me the Way: Ethanolamine Sensing is a Bacterial GPS for Navigating Host Niches. Melissa Kendall. University of Virginia School of Medicine. 11:45 25(OH)D3 Treatment Improves Inflammatory Pathway on Monocytes Lineage (U937) in Uremic Environment. R.B. de Oliveira Brito, J.F. Rebello, W.R. ‘dos Santos Oliveira, C.C. Grabulosa, Y.S. Matos, C.S. Malta, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil. (695.4) 12:00 Molecular Mechanisms Underlying Angiotensin II-Induced Angiotensin Converting Enzyme 2 Internalization and Degradation. B. Ogunlade, S. Sriramula, E. Lazartigues, J.J. Guidry, C.M. Filipeanu. Howard University and Louisiana State University Health Sciences Center. (1005.5) 12:15 Modulation of Lemur Tyrosine Kinase 2 (LMTK2) Expression by TPA Response Elements. I.A. Dey, N.A. Bradbury. Chicago Medical School. (1005.4)

501. IMPACT OF DAIRY BASED NUTRITIONAL INTERVENTIONS ON CARDIOMETABOLIC HEALTH Featured Topic (Sponsored by: Environmental and Exercise Physiology Section) Tue. 10:30 am—McCormick Place Convention Center, W192B Chaired: L. Alexander and B. Miller Microbiome 10:30

Potential Benefits of Dairy Product Intake on Muscle Metabolic Health. Adam Konopka. Colorado State University. 11:00 Whey Protein Improves Glucose Uptake Following Exercise via DPP-IV and IL-6. L.E. Neidert, H.A. Kluess. Auburn University. (1035.3)

162

TUESDAY PHYSIOLOGY 11:15

High-Intensity Interval Training with or Without PostExercise Milk Consumption Improves Cardiovascular Function in Patients with Type 2 Diabetes. M.E. Francois, C. Durrer, J. Little. University of British Columbia Okanagan, Canada. (1035.2) 11:30 Effects of Whole Milk and Full-Fat Dairy Products on Blood Pressure in Patients with Elevated Blood Pressure. S. Roy, B. Baker, S. LaPierre, W. Geary, L. Delfausse, E. Pasha, H. Tanaka. The University of Texas at Austin. (1035.1) 11:45 Dairy Cheese Ingestion Does Not Improve Acute SodiumInduced Cutaneous Microvascular Dysfunction Through Arginase or Inducible Nitric Oxide Synthase Mechanisms. B.K. Alba, A.E. Stanhewicz, W. Kenney, L.M. Alexander. The Pennsylvania State University. (1035.4) 12:00 Exercise and Dairy Protein Interactions in the Treatment of Obesity. S. Trottier. University of Guelph, Canada. (1035.5) 12:15 Dairy Protein and Sodium-Induced Vascular Dysfunction1. Anna Stanhewicz. The Penn State Univ.

502. SODIUM HOMEOSTASIS IN METABOLIC SYNDROME: SORTING OUT NEW AND OLD PLAYERS Symposium (Sponsored by: Water and Electrolyte Homeostasis Section) Tue. 10:30 am—McCormick Place Convention Center, W196C Chaired: C. Ecelbarger and S. Tiwari Ion Channels and Transporters Microbiome Salt 10:30 The Renal Thick Ascending Limb and ObesityAssociated Sodium Retention: Culprit or Innocent ByStander? Dexter Lee. Howard University. 11:00 Integrative Sodium Reabsorption along the Renal Tubule: Global Impact of Metabolic Syndrome. Carolyn Ecelbarger. Georgetown University. 11:30 Regulation of ENaC by Insulin and IGF1: Are They Distinguishable? Alexander Staruschenko. Medical College of Wisconsin. 12:00 Metabolic Syndrome, Insulin, and Renal Sodium Handling. Vivek Bhalla. Stanford Univ. Sch. of Med.

503. NEW INSIGHTS INTO THE ROLE OF HYPOTHALAMIC PEPTIDES IN THE CONTROL OF APPETITE AND ENERGY BALANCE Featured Topic (Sponsored by: CNS Section) Tue. 10:30 am—McCormick Place Convention Center, W196A Chaired: J. Blevins and Z. Song Neurophysiology Energy Homeostasis Neurobiology 10:30

Role of Hypothalamic Oxytocin Signaling in the Control of Appetite and Energy Balance. Zhilin Song. University of Colorado. 11:00 The Effects of Glutamate on Oxytocin Release. Y.A. Badmus, R. Cantley, J.W. Hill. University of Toledo College of Medicine. (1038.7) 11:15 Medullary Reticular GABAergic Neurons That Mediate Hunger Responses Induced by Hypothalamic Neuropeptide Y. Y. Nakamura, Y. Yanagawa, S.F. Morrison, K. Nakamura. Nagoya University Graduate School of Medicine, Japan, Gunma University Graduate School of Medicine, Japan, Oregon Health & Science University and JST, Japan. (1040.4) 11:30 Endoplasmic Reticulum Stress in the Paraventricular Nucleus of the Hypothalamus During Diet-Induced Non-Alcoholic Fatty Liver Disease. K. Blackmore, J. Jeong, C.N. Young. George Washington University and School of Medicine and Health Sciences. (1038.5) 11:45 TNFα Exposure Induces Neuroinflammation and Insulin Resistance in a Rat-Derived Hypothalamic Cell Model, rHypoE-7. M.N. Clemenzi, M.E. Aljghami, L. Wellhauser, D.D. Belsham. University of Toronto, Canada. (1038.4) 12:00 Protein Tyrosine Phosphatase 1b (PTP1B) Deficiency in Proopiomelanocortin (POMC) Neurons Attenuates Body Weight, Fat Mass and Liver Lipid Accumulation in Mice Fed a High Fat Diet. N. Aberdein, Z. Wang, J.M. do Carmo, T. Fang, J.E. Hall. University of Mississippi Medical Center. (1038.6) 12:15 AT1A Receptors in AgRP Neurons Disinhibit αMSH Neurotransmission. K.E. Claflin, D.A. Morgan, K. Rahmouni, J.L. Grobe. (1038.1)

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504. REGULATION OF GLOMERULI PHYSIOLOGICAL FUNCTION: PODOCYTES AND BEYOND Symposium (Sponsored by: Renal Section) Tue. 10:30 am—McCormick Place Convention Center, W192C Chaired: D. Ilatovskaya and J. Reiser

507. KALEY LECTURE FEATURED TOPIC: THE COMPLICATIONS OF DIABETES AND THE ROLE OF INFLAMMATION: MECHANISMS AND THERAPEUTIC OPPORTUNITIES Featured Topic (Cosponsored by: Cardiovascular Section and Microcirculatory Society)

Ion Channels and Transporters

Tue. 10:30 am—McCormick Place Convention Center, W190B

Hypertension

Chaired: A.M. Schmidt

Salt

Inflammation/Immunity

10:30 Glomerular Endothelium and its Interactions with Podocytes. Susan Quaggin. Northwestern University. 11:00 Using 2-Photon Microscopy to Understand Albuminuria. Bruce Molitoris. Indiana University. 11:30 Role of TRPC Channels in the Pathobiology of Podocytes. Oleg Palygin. Medical College of Wisconsin. 12:00 Proteostatic Mechanisms in Glomerular Pathophysiology. Markus Rinschen. University of Cologne.

505. MECHANISMS OF STIFFENING IN LARGE AND SMALL VESSELS: FROM THE CYTOSKELETON TO THE EXTRACELLULAR MATRIX Symposium (Sponsored by: Cardiovascular Section) Tue. 10:30 am—McCormick Place Convention Center, W196B Chaired: L. Martinez-Lemus and G. Meininger 10:30

Extracellular Matrix, Aortic Fibrosis and Hypertension. David Harrison. Vanderbilt University Medical Center. 11:00 Aging and Arterial Stiffening. Stephen Vatner. Rutgers New Jersey Medical School. 11:30 Diabetes and Microvascular Remodeling. Aaron Trask. Nationwide Children’s Hospital. 12:00 Mineralocorticoid Receptor Signaling and Arterial Stiffening. Jim Sowers. University of Missouri.

506. JULIUS H. COMROE, JR. DISTINGUISHED LECTURESHIP OF THE APS RESPIRATION SECTION Lecture Tue. 10:30 am—McCormick Place Convention Center, W190A 10:30 Lung and Muscle Heterogeneity: Consequences for Oxygen Transport Limitation. Peter Wagner. University of California, San Diego.

10:30 RAGE Signal Transduction Mediates Chronic Inflammation in Obesity, Diabetes and its Complication: Mechanisms and Therapeutic Opportunities. Ann Marie Schmidt. New York Univ. Med. Col. 11:30 Smooth Muscle Cells Are the Source of Heart FailureCausing Methylglyoxal in Diabetes Mellitus. K.R. Bidasee, F. Alomar, R. Fang, J.L. Cox, G.J. Rozanski, J. Singh. University of Nebraska Medical Center, University of Dammam, Saudi Arabia, Shandong University School of Medicine, People’s Republic of China, and University of Central Lancashire, United Kingdom. (1013.1) 11:45 Leptin Replacement Therapy Restores Endothelial Function in Mouse Models of Congenital and Acquired Lipodystrophy by Reducing NOX-1 and NOX-4-Derived Reactive Oxygen Species. T. Bruder do Nascimento, S. Kennard, W. Chen, E.J. Belin de Chantemèle. Augusta University. (1013.2) 12:00 Myeloid-Derived Suppressor Cells in Adipose Tissue Homeostasis. K.B. Stivers, P. Chilton, J. Beare, J. Dale, C.L. Kaufman, J.B. Hoying. Cardiovascular Innovation Institute, University of Louisville and Christine M Kleinert Institute. (1013.3) 12:15 Exercise Reverses Metabolic Syndrome Perivascular Adipose Tissue Impairment of Aortic Relaxation. E. DeVallance, K. Branyan, K. Lemaster, S. Clayton, C. Killmer, J. Frisbee, P. Chantler. West Virginia University and Western University, Canada. (1013.4)

508. THE HOT ZONE: SKELETAL MUSCLE CHANGES CAUSED BY HYPERTHERMIA AND HEAT STRESS Featured Topic (Sponsored by: Muscle Biology Group) Tue. 10:30 am—McCormick Place Convention Center, W192A Chaired: J. Selsby Muscle Metabolism 10:30 Metabolic Changes in Skeletal Muscle Caused by Prolonged Heat Stress. Robert Rhodes. Virginia Tech University.

164

TUESDAY PHYSIOLOGY 11:00

A Single Bout of Heat Stress Treatment Increases Nrf2 and Its Target Genes in Mouse Skeletal Muscle. Y. Tamura, Y. Kitaoka, K. Nakazato, H. Hatta. York University, Canada, Nippon Sport Science University, Japan and The University of Tokyo, Japan. (1023.1) 11:15 Hyperthermia and Extracellular Hyperosmolality Affect Sarcolemmal Damage and Protein Oxidation in Mammalian Skeletal Muscle in Vitro. O. Laitano, A.J. Mattingly, G.P. Robinson, C.K. Garcia, T.L. Clanton. University of Florida and Federal University of Vale do São Francisco, Brazil. (1023.2) 11:30 Effect of Core Temperature During Exercise on Markers of Muscle Injury and Oxidative Stress. J. Starnes, T. Herberg, K. Lee, L. Hixson, L. Vervaecke, A. Goldfarb. UNC Greensboro. (1023.3) 11:45 Prolonged Heat Stress Altered Autophagy Signaling in Oxidative Skeletal Muscle. J. Selsby, S. Ganesan, A.J. Brownstein, N.K. Gabler, S.C. Pearce, L.H. Baumgard, R.P. Rhoads. Iowa State University and Virginia Tech. (1023.4) 12:00 Integrity of Intestinal Mucosa and Serum Concentration of Some Metabolites in Pigs Exposed to Acute and Chronic Heat Stress. A. Morales, N. Vásquez, T. Gómez, N. Ibarra, H. Bernal, L. Rodríguez, M. Cervantes. Universidad Autónoma de Baja California, Mexico and Universidad Autónoma de Nuevo León, Mexico. (1018.8) 12:15 A Single Bout of Cryotherapy Does Not Alter the Transcriptome or Metabolome of Human Skeletal Muscle. D.C. Sarver, K.B. Sugg, N.P. Disser, E.R. Siblinsky Enselman, C.L. Mendias. University of Michigan. (1023.5)

511. TWENTY YEARS OF PHYSIOLOGICAL GENOMICS Symposium (Sponsored by: History of Physiology Group) Tue. 3:15 pm—McCormick Place Convention Center, W190B Chaired: M.R. Garrett and A.S. Greene Genetics, Epigenetics, MicroRNA 3:15

Introductory Remarks. Andrew Greene. Med. Col. of Wisconsin. 3:20 The Impact of Physiological Genomics on The American Physiological Society. Martin Frank. APS. 3:30 The Impact of Physiological Genomics on CV/Renal Physiology. Allen Cowley. Med. Col. of Wisconsin. 3:55 Physiological Genomics in GI Physiology. Jason Mills. Washington Univ. Sch. of Med. 4:20 Physiological Genomic Approaches: From Rats to Humans. Howard Jacob. HudsonAlpha Inst. for Biotechnology. 4:45 The Future Avatar of Physiological Genomics? Bina Joe. Univ. of Toledo.

512. HANS USSING LECTURE FEATURED TOPIC Featured Topic (Sponsored by: Epithelial Transport Group) Tue. 3:15 pm—McCormick Place Convention Center, W192A

509. HISTORY OF PHYSIOLOGY LECTURE

1:00

Chaired: J. Klein

Lecture

Ion Channels and Transporters

(Sponsored by: History of Physiology Group)

Hypertension

Tue. 1:00 pm—Hyatt Regency McCormick Place Hotel, Regency Ballroom A

Salt

The XIIIth International Physiological Congress in Boston in 1929: American Physiology Comes of Age. Jack Rall. Ohio State Univ.

510. ROBERT M. BERNE DISTINGUISHED LECTURESHIP OF THE APS CARDIOVASCULAR SECTION

3:15 4:00

4:15

Lecture Tue. 2:00 pm—McCormick Place Convention Center, W190A 2:00

Astronauts, Athletes, and Aging. A TripTik Guide to the Cardiovascular Adaptation to Physical Activity. Benjamin Levine. Texas Health Presbyterian Hospital Dallas.

4:30

Hans Ussing Lecture: Imaging Renal and Intestinal Phosphate Transporter Dynamics. Moshe Levi. University of Colorado. Regulated Expression of the Na+/K+-ATPase Pump in Colonic Epithelium by Bile Acids. J.F. Borg, J. Yde, Q. Wu, N. Lajczak, S. Keely, R.A. Fenton, H. Moeller. Aarhus University, Denmark and Royal College of Surgeons in Ireland, Ireland. (856.10) Intestine-Specific Dual Oxidase Deficiency Lacks ATPP2Y-Mediated Luminal H2O2 Production in Mice. K. Maruta, Y. Akiba, I. Kaji, J.D. Kaunitz. UCLA & WLA VAMC. (856.20) Stimulation of Sweet Taste Receptors Expressed in the Kidney Enhance Surface NKCC2 Levels in Thick Ascending Limbs (TALs). G. Ares, P. Caceres, K.M. Kassem, P.A. Ortiz. Henry Ford Health System. (856.16)

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5:00

The Epithelial Sodium Channel (ENaC) α- and γ-Subunits Are Cleaved by Furin in Human Kidney. R.Z. Langkilde, M.K. Mikkelsen, K. Skjødt, R. Zamani, N. Marcussen, B. Jensen, P. Svenningsen. University of Southern Denmark, nstitute of Molecular Medicine, Denmark, Institute of Molecular Medicine, Denmark, Odense University Hospital, Denmark, University of Southern Denmark and Odense University Hospital, Denmark. (856.3) A Cysteine-Rich Hydrophobic Motif in KS-WNK1 Regulates WNK Body Formation. C.R. BoydShiwarski, D.J. Shiwarski, L.J. Nkashama, A. Roy, D.B. Stolz, M. Puthenveedu, A.R. Subramanya. University of Pittsburgh and Carnegie Mellon University. (856.8)

5:00

514. MULTI-OMICS TO STUDY THE CELLULAR PATHOPHYSIOLOGY OF NEURODEGENERATIVE DISEASES Symposium

513. THE INTEGRATED PHYSIOLOGICAL RESPONSE TO HEAT STRESS IN VULNERABLE POPULATIONS

(Sponsored by: Cell and Molecular Physiology Section) Tue. 3:15 pm—McCormick Place Convention Center, W194B

Featured Topic

Chaired: S. Pimplikar

(Sponsored by: Environmental and Exercise Physiology Section)

Neurophysiology Neurobiology

Tue. 3:15 pm—McCormick Place Convention Center, W193 Chaired: M. Sawka

3:15

Physiology of Extreme Environments 3:15 3:45

4:00

4:15

4:30

4:45

166

Neural and Cardiovascular Responses to Heat Stress in the Elderly. Daniel Gagnon. Univ. of Montreal. Prior Infection and Prior Heat Illness as Risk Factors for Exertional Heat Stroke. M.A. King, M.D. Ward, C.H. Gabrial, G.N. Audet, B. Adams, L.R. Leon. US Army Research Institute for Environmental Medicine and Defense Health Agency. (1018.4) Impact of Air Temperature on Core Temperature Regulation During Exercise Using a Simulated Burn Injury Model. M.N. Cramer, G. Moralez, K. Kouda, D. Gagnon, C.G. Crandall. Institute for Exercise and Environmental Medicine, Wakayama Medical University, Japan and Montreal Heart Institute and Université de Montréal, Canada. (1018.9) Preserved Tolerance to Lower-Body Negative Pressure During Heat Stress in Individuals with Multiple Sclerosis. M. Huang, D.R. Allen, D.M. Keller, P.J. Fadel, E.M. Frohman, S.L. Davis. Southern Methodist University, University of Texas at Arlington and University of Texas Southwestern Medical Center. (1018.11) Exaggerated Hemodynamic Responses Upon the Initiation of Thermoregulatory Behavior in “At Risk” Older Adults. Z.J. Schlader, G.L. Coleman, J.R. Sackett, S. Sarker, C.L. Chapman, D. Hostler, B.D. Johnson. University at Buffalo. (1018.1) Arginase Inhibition and Low-Dose Sodium Nitroprusside Administration Do Not Influence Heat Loss Responses During Exercise in Aged Humans. R.D. Meade, N. Fujii, L.M. Alexander, J.C. Louie, P. Boulay, R.J. Sigal, G.P. Kenny. University of Ottawa, Canada, University of Tsukuba, Japan, Pennsylvania State University, University of Sherbrooke, Canada and University of Calgary, Canada. (1018.2)

Whole-Body Heat Stress Does Not Appear to Reduce β1-Adrenergic Responsiveness in Heat Stressed Older Individuals. G. Moralez, K. Kouda, M. Hieda, E. Hardin, S. Sarma, S.A. Romero, M.N. Cramer, D. Gagnon, A.N. Adams, M.F. Jaffery, C.G. Crandall. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Wakayama Medical Center, Japan, Japan and Montreal Heart Institute and Université de Montréal, Canada. (1018.12)

3:45 4:15 4:45

Genomic Approaches Toward a Greater Understanding of Alzheimer’s Disease. Alison Goate. Icahn School of Medicine at Mount Sinai. De-Mystifying Microglia during Neurodegeneration Using Transcriptomic and Epigenomic Approaches. TBD. Multiscale Network Models of Alzheimer’s Disease. Bin Zhang. Icahn School of Medicine at Mount Sinai. Blood Metabolite Markers of Alzheimer’s Disease: Promise and Challenges. Madhav Thambisetty. National Institute on Aging, NIH.

515. CENTRAL NEUROMODULATION IN THE CONTROL OF BREATHING Featured Topic (Sponsored by: Respiration Section) Tue. 3:15 pm—McCormick Place Convention Center, W196C Chaired: A.J. Garcia and G. Mitchell Neurophysiology Ion Channels and Transporters Neurobiology 3:15 3:35

3:55

Contribution of the Serotonin System in Respiratory and Autonomic Dysregulation in Premature Infants. JeanCharles Viemari. CNRS-Aix Marseille Université. Kir5.1 Channel Disruption Alters Acute and Chronic pH Regulation, Central 5-HT, and Causes Audiogenic Seizures. Matthew Hodges. Medical College of Wisconsin. Questions for Invited Speakers.

TUESDAY PHYSIOLOGY 4:00 Embryonic Rhombomere Hindbrain Patterning Delineates Distinct Functional Neuron Populations in the Adult Central Noradrenergic System. J.J. Sun, M. Key, V.K. Martinez, F. Saldana Morales, P. Zhu, R.S. Ray. Baylor College of Medicine and University of North Carolina School of Medicine. (1053.8) 4:15 Genetic Deletion of Mu Opioid Receptors from Kölliker-Fuse Neurons Reduces MorphineInduced Respiratory Depression. E.S. Levitt, J.M. Bissonnette, B. Kieffer. University of Florida, Oregon Health & Science University, Douglas Research Centre and McGill University, Canada. (1053.17) 4:30 Mechanisms of Cross-Talk Inhibition Between Phrenic Motor Facilitation Elicited by 5-HT2B and 5-HT7 Receptors. R.R. Perim, D.P. Fields, G.S. Mitchell. University of Florida. (1053.14) 4:45 5HT Depletion Blunts Arousal and Chemoreflex Responses Coupled with Breathing Instability and Cardiac Dysfunction in Mice. D. Komnenov, A. Pop, D. Kuhn, J. Mateika. Wayne State University School of Medicine and John D. Dingell VA Medical Center. (1053.6) 5:00 Thyroid Hormone Deficiency Potentiates GABAergic Inhibition of the Brainstem Respiratory Network in Newborn Rat. J. Rousseau, L. Tenorio, R. Kinkead. Université Laval, Canada. (1053.10)

517. EXERCISE INTOLERANCE IN METABOLIC, PULMONARY AND CARDIOVASCULAR DISEASES: DID WE FORGET THE BRAIN?

516. CENTRAL GLP-1 RECEPTORS IN THE REGULATION OF ENERGY HOMEOSTASIS

4:45

Symposium (Sponsored by: Endocrinology and Metabolism Section) Tue. 3:15 pm—McCormick Place Convention Center, W192B Chaired: W. Langhans Energy Homeostasis 3:15 3:45 4:15 4:45

Vagal Neuropeptide CART is Required to Mediate Physiological Effects of Gut GLP1. Guillaume De Lartigue. Yale. Emerging Role of Endogenous Central GLP-1 in Brown Adipose Tissue Thermogenesis. Shin Lee. ETH Zurich. Insights into the Cellular and Molecular Signaling Events of the Central GLP-1 Receptor. Matthew Hayes. University of Pennsylvania. Neural Substrates Engaged by GLP-1 to Impact on Feeding and Reward: Unexpected Role of Interleukins and Sex Steroids. Karolina Skibicka. University of Gothenburg.

Symposium (Sponsored by: Integrative Physiology Symposium Series) Tue. 3:15 pm—McCormick Place Convention Center, W375A Chaired: P. Brassard and D.M. Bailey Neurophysiology Oxygen Transport Neurobiology 3:15 3:45 4:15

Cerebral Blood Flow and Oxygenation in Humans: Dynamic Evaluation and Regulation during Exercise. Damian Bailey. University of South Wales. Cerebral Blood Flow and Oxygenation during Exercise in Patients with Heart Failure and Pulmonary Arterial Hypertension. Patrice Brassard. Université Laval. Cerebral Blood Flow and Oxygenation During Exercise in Patients With a Combination of Chronic Obstructive Pulmonary Disease and Heart Failure. Mayron Oliveira. Federal University of São Paulo. Cerebral Blood Flow and Oxygenation during Exercise in Patients with Type 2 Diabetes. Johannes Van Lieshout. University of Amsterdam.

518. ROLE OF CNS OSMOSENSORY NETWORKS IN THE REGULATION OF CARDIOVASCULAR FUNCTION IN HEALTH AND DISEASE Symposium (Sponsored by: CNS Section) Tue. 3:15 pm—McCormick Place Convention Center, W196A Chaired: J.E. Stern Neurophysiology Hypertension Salt 3:15 Network Plasticity in Baroreceptor Control of Magnocellular Vasopressin Neurons. Charles Bourque. McGill University. 3:45 Interfacing Osmosensitive Sympathoexcitatory Neurons with the Brainstem Sympathetic Rhythm Generating Network. Glenn Toney. University of Texas Helath Science Center.

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4:45

Mechanistic Insights into Purinergic Signaling at Hypothalamus Level in the Control of Salt-Induced Sympathoexcitation. Vagner Antunes. University of Sao Paulo. Osmotically-Driven Dendritic Release of VP and Its Impact on Hypothalamic Sympathetic Outflow. Javier Stern. Georgia Regents University.

519. HORACE W. DAVENPORT DISTINGUISHED LECTURESHIP OF THE APS GASTROINTESTINAL AND LIVER PHYSIOLOGY SECTION Lecture Tue. 3:15 pm—McCormick Place Convention Center, W190A Inflammation/Immunity 3:15

Why the GI Tract Does Not Digest Itself: A DavenportInspired Journey. John Wallace. Antibe Therapeutics and University of Calgary.

520. SEX DIFFERENCES IN DIABETES, OBESITY AND BLOOD PRESSURE CONTROL Symposium Sex/Gender Research Interest Group Tue. 3:15 pm—McCormick Place Convention Center, W192C Chaired: G. Kararigas and S. Lindsey Sex Differences and Women’s Health Energy Homeostasis Hypertension 3:15 3:45 4:15 4:45

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Novel Mechanisms of Antidiabetic Actions of Estrogens in Women. Frank Mauvais-Jarvis. Tulane Univ. Impact of Menopause on the Disease Risk of NonAlcoholic Fatty Liver Disease. Ayako Suzuki. Duke Univ. Obesity-Induced Increases in Sympathetic Nerve Activity: Sex Matters. Virginia Brooks. University of Oregon. Aging and Role of SNA in Blood Pressure Control in Women. Nishi Charkoudian. USARIEM, Natick.

521. AUGUST KROGH DISTINGUISHED LECTURESHIP OF THE APS COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY SECTION Lecture (Supported by Novo Nordisk Fonden) Tue. 3:15 pm—McCormick Place Convention Center, W196B 3:15

Developmental Plasticity, Epigenetics and Evolution: A Comparative Physiologist’s Od(d)yssey. Warren Burggren. University of North Texas.

522. APS BUSINESS MEETING Business Meeting APS Tue. 5:45 pm—McCormick Place Convention Center, W375A

WEDNESDAY BIOCHEMISTRY

WEDNESDAY, APRIL 26 Biochemistry and Molecular Biology 523. ASBMB-MERCK AWARD

526. MOLECULAR QUALITY CONTROL

Award Lecture

Symposium

(Sponsored by: Merck)

Wed. 10:00 am—McCormick Place Convention Center, W184BC

Wed. 8:45 am—McCormick Place Convention Center, W183AB 8:45 Introduction. 8:50 523.1 Proteostasis Function and Disfunction: The Delicate Art of Maintaining a Healthy Proteome. J. Frydman. Stanford University.

Chaired: D. Ron

9:15 Introduction. 9:20 524.1 Structure-Based Discovery of New Chemotypes Conferring New Biology. B. Shoichet. University of California at San Francisco.

10:00 526.1 Regulation of Translational Fidelity and Neurodegeneration. S.L. Ackerman. UCSD and HHMI. 10:25 526.2 A Versatile Chaperone Network Promoting the Aggregation and Disaggregation of Misfolded Proteins. B. Bukau, N. Nillegoda, A. Wentink, S. Ungelenk, C. Ho, A. Mogk. Zentrum für Molekulare Biologie der Universität Heidelberg, Germany. 10:50 526.3 Structures and Functions of the Ribosome Quality Control Complex or RQC. A. Frost. University of California at San Francisco. 11:15 526.4 RNA Decay and Quality Control by the Eukaryotic RNA Exosome. C.D. Lima. Memorial Sloan Kettering Cancer Center/HHMI. 11:40 526.5 Tuning an Endoplasmic Reticulum Chaperone to the Cell’s Needs. D. Ron. University of Cambridge, United Kingdom.

525. LOW COMPLEXITY DOMAIN PROTEINS AND THE MAKING OF GERM CELLS

527. NEW INSIGHTS IN REGULATED LIPID METABOLISM

524. DELANO AWARD FOR COMPUTATIONAL BIOSCIENCES Award Lecture Wed. 9:15 am—McCormick Place Convention Center, W183AB

Symposium

Symposium

Wed. 10:00 am—McCormick Place Convention Center, W183C

Wed. 10:00 am—McCormick Place Convention Center, W185BC

10:00 525.1 RNA Granule Organization. R. Lehmann, T. Trcek, M. Grosch, H. Shroff, T. Lionnet. Skirball Institute, NYU School of Medicine, HHMI, National Institute of Biomedical Imaging and Bioengineering, Janelia Research Campus and Howard Hughes Medical Institute. 10:30 525.2 Organelles Without Membranes: Intrinsically Disordered Proteins Bring Order to the Cytoplasm. G. Seydoux, J. Smith, D. Calidas, H. Schmidt, D. Rasoloson. Johns Hopkins University School of Medicine and HHMI. 11:00 525.3 A Liquid Crystalline Interface Between Chromosomes Regulates Meiotic Recombination. A.F. Dernburg, S. Köhler, L. Zhang, W.T. Stauffer, J.D. Robinson, O. Rog. University of California, Berkeley, HHMI and University of Utah. 11:30 525.4 Amyloid-Mediated Translational Control Is Required for Meiosis. L.E. Berchowitz, M.R. Walker, G.L. Kabachinski, T.U. Schwartz, A. Amon. Massachusetts Institute of Technology, HHMI.

Chaired: R. Zechner 10:00 527.1 The Role of Intracellular Lipolysis in Thermogenesis and Metabolic Disease. R. Zechner, M. Schweiger, R. Breinbauer, R. Zimmermann. University of Graz, Austria and Graz University of Technology, Austria. 10:30 527.2 New Insights Into Intravascular Lipolysis and New Causes of Hypertriglyceridemia. S.G.Young, A. Beigneux, L. Fong, M. Ploug. UCLA and Finsen Laboratory, Denmark. 11:00 527.3 Novel Mechanisms of Regulation of Bioactive Sphingolipids in Cancer Biology. L.M. Obeid, C. Senkal, M. Pulkoski-Gross. Stony Brook University School of Medicine and Stony Brook University. 11:30 527.4 Geranylgeranyl-Regulated, ER-to-Golgi Transport of UBIAD1: Implications for Cholesterol Homeostasis and Schnyder Corneal Dystrophy. R.A. DeBose-Boyd. UT Southwestern Medical Center.

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528. REDOX SIGNALING AND THE METABOLOME

530. ASBMB MEET THE SPEAKERS

Symposium

Special Event

Wed. 10:00 am—McCormick Place Convention Center, W186ABC

Wed. 1:30 pm—McCormick Place Convention Center, Skyline Ballroom

Chaired: R. Banerjee 10:00 528.1 Mechanism and Control in Radical SAM Enzymes. J.B. Broderick. Montana State University. 10:30 528.2 Biocatalyst Discovery from the Secondary Metabolome. D.H. Sherman, S. Li, A.N. Lowell, S.A. Newmister, F. Yu, R.M. Williams. Life Sciences Institute, University of Michigan, University of Michigan, Life Sciences Institute and Colorado State University. 11:00 528.3 Redox Control of the Metabolome and the Aging Process. V. Gladyshev. Harvard Medical School and Brigham & Women’s Hospital. 11:30 528.4 Signaling Through Hydrogen Sulfide. R. Banerjee. University of Michigan Medical School.

Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • S. Ackerman, UCSD, HHMI • R. Banerjee, Univ. of Michigan Med. Sch. • B. Bukau, Zentrum für Molekulare Biologie der Universität Heidelberg • A. Frost, UCSF • C. Lima, Memorial Sloan Kettering Cancer Ctr. • D. Ron, Univ. of Cambridge

529. ASBMB MEET THE SPEAKERS Special Event Wed. 12:30 pm—McCormick Place Convention Center, Skyline Ballroom Join us in the exhibit hall, across from ASBMB booth #1214. Meet-up with the morning presenters for continued scientific discussion and networking in an informal environment. As of press time, confirmed speakers include: • A. Amon, MIT, HHMI • R. DeBose-Boyd, UT Southwestern Med. Ctr. at Dallas • A. Dernburg, UC, Berkeley • G. Seydoux, Johns Hopkins Univ. Sch. of Med., HHMI • B. Shoichet, UCSF, Delano Award for Computational Sciences • R. Zechner, Inst. of Molecular Biosciences, Karl Franzens Universität Graz

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• D. Sherman, Univ. of Michigan

WEDNESDAY PATHOLOGY

Pathology 531. LIVER REGENERATIVE MEDICINE Minisymposium Wed. 8:30 am—McCormick Place Convention Center, W181B Chaired: G. Alpini and J. Sanders Liver Pathobiology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) 8:30 531.1 Modeling Cellular Network Dynamics of Liver Homeostatic Renewal. R. Vadigepalli, D. Cook, B. Ogunnaike. Thomas Jefferson University and University of Delaware. 8:45 531.2 Role of Hepatic O-GlcNAcylation on Acetaminophen-Induced Liver Injury. S. McGreal, B. Bhushan, C. Walesky, M.R. McGill, J.L. Weemhoff, H.J. Jaeschke, Z. Zhang, E. Tan, C. Slawson, N.E. Zachara. University of Kansas Medical Center and John Hopkins University. 9:00 531.3 Thrombospondin-1 Contributes to Hepatic Pathology and Systemic Complications in the Acetaminophen and Azoxymethane Mouse Models of Acute Liver Failure. M. McMillin, S. Grant, G. Frampton, G. Alpini, S. DeMorrow. Central Texas Veterans Health Care System and Texas A&M University Health Science Center. 9:15 531.4 Role of Hepatocyte Nuclear Factor 4 Alpha (HNF4α) in Hepatocyte Regeneration. I. Huck, U. Apte. University of Kansas Medical Center. 9:30 531.5 Cell-Specific Wnts Regulate Liver Regeneration After Partial Hepatectomy. M. Preziosi, J.o. Yang, H. Okabe, C. Diegel, B. Williams, S. Monga. University of Pittsburgh and Van Andel Institute.

9:45 531.6 Role of MET and EGFR Signaling in Hepatomegaly and Hepatocyte Proliferation Induced by TCPOBOP (1,4-Bis [2-(3,5-Dichloropyridyloxy)] Benzene) in Mice. B. Bhushan, M.M. Haynes, W.M. Mars, A. Orr, W.C. Bowen, S. Paranjpe, G.K. Michalopoulos. School of Medicine and University of Pittsburgh. 10:00 531.7 Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in HepatocyteDriven Liver Regeneration. J.O. Russell, S. Ko, D. Shin, S.P. Monga. University of Pittsburgh. 10:15 531.8 P53 Regulates Progression of Injury and Liver Regeneration After Acetaminophen Overdose. P. Borude, B. Bhushan, H. Chavan, J.L. Weemhoff, H. Jaeschke, P. Krishnamurthy, U. Apte. University of Kansas Medical Center. 10:30 531.9 Beta-Catenin Dependent Wnt Signaling Promotes Hepatocyte-To-Cholangiocyte Transdifferentiation. K. Kosar, K. Nejak-Bowen. University of Pittsburgh School of Medicine. 10:45 531.10 Phenobarbital Induces ATZ Globule Clearance in a Mouse Model of Alpha-1 Antitrypsin Deficiency. A.W. Bell, J. Stoops, M. Oertel, G.K. Michalopoulos. University of Pittsburgh. 11:00 531.11 Proliferation of Transplanted Hepatocytes Drives Efficient Repopulation in Juvenile Host Rat Livers. P. Stock, M. Hempel, M. Hsu, B. Christ. University of Leipzig, Germany. 11:15 531.12 Rat Liver Repopulation by Transplanted Late Gestation Fetal Hepatocytes. J. Sanders, J. Boylan, H. Francois-Vaughan, P.M. Thomas, J. Sikora, N. Abshiru, P. Gruppuso, N. Kelleher. Brown University, Rhode Island Hospital & Alpert Medical School of Brown University and Feinberg School of Medicine Northwestern University.

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Pharmacology 532. NORMAN WEINER LECTURE Lecture

534. NONPHARMACOLOGICAL FACTORS INFLUENCING DRUG ACTION Symposium

Wed. 8:30 am—McCormick Place Convention Center, W470B

(Sponsored by: ASPET Division for Behavioral Pharmacology)

The Norman Weiner Lecture was established in memory of Dr. Norman Weiner, past ASPET President and chair of the Department of Pharmacology at the University of Colorado. It is in honor of his many contributions to both ASPET and to pharmacology research and education.

Wed. 9:30 am—McCormick Place Convention Center, W471A Chaired: M.A. Nader Behavioral Pharmacology

This lecture runs from 8:30 am–9:20 am. 8:30 Introduction. David Sibley. ASPET. 8:35 Drug Discrimination Procedures and in vivo Pharmacological Analysis. Jack Bergman. Harvard Medical School/McLean Hospital.

533. CHEMICAL BIOLOGY AND DRUG DISCOVERY IN EPIGENETICS Symposium (Sponsored by: ASPET Division for Molecular Pharmacology) Wed. 9:30 am—McCormick Place Convention Center, W470A Chaired: D. Wang and C. He Molecular Pharmacology Cancer Biology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials)

Neuropharmacology Pharmacology Education This session runs from 9:30 am–12:00 pm. 9:30

Influence of Feeding Conditions on the Behavioral Effects of Drugs. Charles France. Univ. of Texas Health Science Center at San Antonio. 10:00 Effects of High Fat Diet and Feeding Pattern on Dopamine Responses to Stimulants. Steven Fordahl. University of North Carolina at Greensboro. 10:30 Nonpharmacological Variables in Drug SelfAdministration. Mark Smith. Davidson College. 11:00 The Influence of Social Variables on the Behavioral Effects of Drugs in Male and Female Monkeys. Michael Nader. Wake Forest School of Med. 11:30 Implementation of Integrated Therapies for Comorbid Post-traumatic Stress Disorder and Substance Abuse. Therese Killeen. Medical University of South Carolina.

535. RELEASE AND PROCESSING OF EXTRACELLULAR ATP: NEW INSIGHTS AND THERAPEUTIC TARGETS Symposium

This session runs from 9:30 am–12:00 pm. 9:30 Introduction. 9:35 Chemical Biology of Protein Post-translational Modification and Regulation. Philip Cole. Johns Hopkins Univ. 10:00 Probing the Epigenome for Therapeutic Targets. Cheryl Arrowsmith. Univ. of Toronto. 10:25 RNA Methylation in Human Diseases. Chuan He. University of Chicago. 10:50 Chemical Biology of Chromatin Regulation and Drug Discovery. Stephen Frye. University of North Carolina—Chapel Hill. 11:15 Functional Interplay between DNA Demethylation and Transcription. Dong Wang. Univ. of California, San Diego. 11:40 Identification of Epigenetic Targets in the Treatment of Recurrent Breast Cancer. N.W. Mabe. Duke University. (823.9) 11:55 Wrap Up.

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(Sponsored by: ASPET Division for Translational and Clinical Pharmacology) Wed. 9:30 am—McCormick Place Convention Center, W474A Chaired: R. Corriden and A.S. MacLeod Translational and Clinical Pharmacology Molecular Pharmacology Cancer Biology This session runs from 9:30 am–12:00 pm. 9:30

The Pannexin1-alpha Adrenergic Axis Can Mediate Vasoconstriction and Blood Pressure. Brant Isakson. Univ. of Virginia. 10:00 Pannexin1 Channels as Novel Regulators of Cellular Differentiation and Cancer. Silvia Penuela. Western Univ. 10:30 Regulation of CNS Inflammation. Francisco Quintana. Brigham and Women’s Hosp.

WEDNESDAY PHARMACOLOGY 11:00

Sensation of Ultraviolet Radiation-induced Injury and Contribution to DNA Repair by Skin-resident T Cells: The Role of Extracellular ATP and CD39. Amanda MacLeod. Duke University. 11:30 ATP Exposure Increases Expression of α-Synuclein in Sh-Sy5y Cells: Potential Link Between Neuronal Injury and Parkinson’s Disease. J.T. Lamberts, D. Rustem, B. Wallis, C. Zwart. Ferris State University. (814.11) 11:45 Pannexin-1 Channel Activity and Associated ATP Release in Podocytes in Response to Adipokines. G. Li, Q. Zhang, N. Li, J.K. Ritter, P. Li. Virginia Commonwealth University. (991.9)

536. INTESTINE-LIVER CROSSTALK, NEW FRONTIER FOR DRUG METABOLISM, LIVER INJURY AND REPAIR Symposium (Sponsored by: ASPET Division for Toxicology) Wed. 9:30 am—McCormick Place Convention Center, W474B Chaired: G.L. Guo and L.M. Aleksunes Toxicology Inflammation/Immunity Microbiome This session runs from 9:30 am–12:00 pm. 9:30 Introduction. 9:40 Intestine Bile Acid Induced Endocrine Signal in Liver Injury and Repair. Grace Guo. Rutgers Univ.—Ernest Mario Sch. of Pharmacology. 10:05 FXR-FGF15/19 Signaling and Bile Acid Homeostasis During Pregnancy. Lauren Aleksunes. Rutgers Univ. 10:30 Gut Microbiome Regulation of Drug Metabolism and Xenobiotic Exposure. Yue (Julia) Cui. Univ. of Washington. 10:55 The Gut-liver Axis in Eythropoietic Protoprophyria. Xiaochao Ma. Univ. of Pittsburgh. 11:20 Antagonizing Intestinal FXR in Liver Lipid Metabolism Regulation. Frank Gonzalez. NIH. 11:45 Fibroblast Growth Factor 21 Depletion Attenuates Acute Experimental Colitis in Mice Through Epithelial STAT3 Activation. W. Feng, G. Dryden, C. McClain. University of Louisville and Robley Rex VAMC. (995.1) 11:55 Wrap Up.

537. THE PHARMACOLOGICAL AND THERAPEUTIC LEGACY OF DR. ALFRED G. GILMAN Symposium (Sponsored by: ASPET Division for Molecular Pharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W470A Chaired: M.L. Toews and P.C. Sternweis Molecular Pharmacology Cancer Biology Inflammation/Immunity Dr. Alfred G. Gilman was a major contributor to multiple aspects of pharmacology through both his Nobel Prize-winning research on G proteins and adenylyl cyclases and his many years of personally editing Goodman and Gilman’s The Pharmacological Basis of Therapeutics textbook. This symposium will honor his legacy with presentations by a few of his many successful trainees. This session runs from 3:00 pm–5:30 pm. 3:00

Opening Comments. Paul Sternweis. Univ. Texas Southwestern Health Science Center, Pharmacology. 3:10 The Allosteric Interaction Between GPCRs, G Proteins, Small Molecules and Cations. Roger Sunahara. Univ. of California, San Diego. 3:35 G Protein GAPs. Elliott Ross. Univ. of Texas Southwestern Medical Center. 4:00 Break. 4:05 Involement of G12 Proteins in Oncogenesis and Tumor Progression. Patrick Casey. Duke-NUS Medical School, Singapore. 4:30 Spatial Constraints of G protein Regulation of Adenylyl Cyclase. Carmen Dessauer. Univ. of Texas Health Science Center at Houston. 4:55 Crystal Structure Analysis of G Proteins and Adenylyl Cyclases. Stephen Sprang. Univ. of Montana. 5:20 Wrap Up.

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538. DEVELOPING NOVEL THERAPEUTIC STRATEGIES TO MODULATE K+/CL- COTRANSPORTER 2 (KCC2) FUNCTION

3:35 4:05

Symposium (Sponsored by: ASPET Division for Neuropharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W470B Chaired: P.A. Davies and T.G. Deeb

4:35 5:05

Neuropharmacology Drug Discovery and Development Neurobiology This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 A New Role for Erythropoietin (EPO) in Neurorepair: Attenuating KCC2 Loss in the Preterm Brain. Lauren Jantzie. Univ. of New Mexico. 3:30 Small Molecule TrkB Antagonist, ANA-12 Rescues Ischemia Induced KCC2 Degradation and Phenobarbital-resistant Neonatal Seizures in a Dose Dependent Manner. Shilpa Kadam. Kennedy Krieger Inst. and Johns Hopkins Univ. Sch. of Med. 3:55 Mulitprotein Complexes Regulating Excitatory and Inhibitory Neurotransmission in the Brain. Vivek Mahadevan. NIH, McBain Lab (visiting fellow) 4:10 Stretch Break. 4:15 Assessing the Impact of Enhanced KCC2 Function on Seizure Severity. Yvonne Moore. Tufts University School of Medicine. 4:30 KCC2 Pharmacology and Function during Hyperexcited States. Tarek Deeb. Tufts Univ. School of Medicine. 4:55 Restoration of KCC2 Expression Rescues Functional Deficits in Human Neurons Derived from Patients with Rett Syndrome. Xin Tang. Whitehead Institute for Biomedical Research. 5:20 Wrap Up.

539. TRANSPORTER ROLES IN INTRACELLULAR DRUG CONCENTRATIONS Symposium (Sponsored by: ASPET Division for Drug Metabolism) Wed. 3:00 pm—McCormick Place Convention Center, W471A Chaired: Y. Lai and I. Tamai Drug Metabolism Transporters/Channels/Barriers This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Local Transporter Drug—Drug Interaction of Donepezil with Cilostazol Increases Drug Accumulation in Heart. Ikumi Tamai. Kanazawa Univ.

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5:18

Apply a PET Approach to Monitor Hepatic Uptake and Excretory Function. Yuichi Sugiyama. RIKEN Innovation Center Research Cluster for Innovation. The Combination of in vitro Experimental and Modelling Approaches to Predict in vivo Intracellular Partitioning. Yurong Lai. Bristol-Myers Squibb. PBPK Modeling to Estimate the Effects of Renal Impairment and Transporter Inhibition on Drug Exposure in the Kidneys. Ping Zhao. Live Tissue Imaging of Organic Cation and Anion Transport at the Blood-CSF Barrier Reveals Specific Transporter Function and Distinct Transcellular Pathways. T. Hu, W. Zha, H. Duan, J. Wang. University of Washington. (1062.14) Alcohol Induced Changes in Cellular Pharmacokinetics and Pharmacodynamics of Elvitegravir and Darunavir in HIV-1 Infected Monocytic Cells. N.M. Midde, N. Sinha, Y. Gong, B. Meibohm, S. Kumar. University of Tennessee Health Science Center. (822.3)

540. STEM CELLS IN CANCER Symposium (Sponsored by: ASPET Division for Cancer Pharmacology) Wed. 3:00 pm—McCormick Place Convention Center, W474A Chaired: R.K. Guy and S. McKinney-Freeman Cancer Pharmacology Cancer Biology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) This session runs from 3:00 pm–5:30 pm. 3:00 Overview. Shannon McKinney-Freeman. St Jude Children’s Research Hospital. 3:10 Stem Cells in Leukemia. Guy Sauvageau. Univ. of Montreal. 3:40 A Chemical Approach to Controlling Cell Fate. Sheng Ding. Gladstone Institute of Cardiovascular Disease. 4:10 Enhancing Mammalian Regeneration: Mechanisms and Consequences. Hao Zhu. UT Southwestern Medical Center. 4:40 New Targeted Approaches for Pediatric Malignancies. Kimberly Stegmaier. Dana-Farber Cancer Institute. 5:10 Repairing Interstrand DNA Crosslinks (ICL): Characterization of an ICL Incision/Lesion Bypass Polymerase Complex Regulated by the Fanconi Anemia Pathway. V.P. Jasti, S. Sharma, I. Althaus, A. Weinstein, S. Ramani, C. Canman. University of Michigan. (996.3) 5:25 Wrap Up. R. Guy. Univ. of Kentucky Sch. of Pharmacy.

WEDNESDAY PHARMACOLOGY

541. EPIGENETIC REGULATION OF TOXICITY AND IMPLICATIONS FOR RISK ASSESSMENT

4:00 4:30

Symposium (Sponsored by: ASPET Division for Toxicology) Wed. 3:00 pm—McCormick Place Convention Center, W474B

5:00

Chaired: B.S. Cummings and D.C. Dolinoy Toxicology Translational and Clinical Pharmacology Cancer Biology

5:15

Epigenetic Targets of Toxicity and Drivers of Disease. Cheryl Walker. Baylor College of Medicine. Predicting Inter-Individual Variability in Post-Exposure Response: The “Epigenetic Seed and Soil” Model of Susceptibility. Shaun McCullough. U.S. Environmental Protection Agency. Epigenetic Modifications Influence NOD-Like Receptor Expression and Associated Pro-Inflammatory Activity. C. Feerick, D.P. McKernan. NUI Galway, Ireland. (1060.2) Image-Based Screening for Epigenetic Modifiers of Myofibroblast Activation. A.J. Haak, G. Ligresti, R. Abbey, S. Romanov, T.D. Chung, D.J. Tschumperlin Mayo Clinic and Nanosyn Inc. (1060.3)

This session runs from 3:00 pm–5:30 pm. 3:00 Introduction. 3:05 Perinatal Lead (Pb) Exposure and Effects on Offspring DNA Methylation in Mouse and Human Cohorts. Dana Dolinoy. Univ. of Michigan School of Public Health. 3:35 Role of Epigenetics in the Molecualr Mechanisms of Action of Renal Cell Death Induced by the Water Disinfection Byproduct Bromate. Brian Cummings. Univ. of Georgia-Athens College of Pharmacy.

542. ASPET CLOSING RECEPTION Special Event Wed. 6:00 pm —McCormick Place Convention Center, Skyline Ballroom Pre-Function Area We invite ASPET members and pharmacology attendees to join us for a closing reception.

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PHYSIOLOGY WEDNESDAY

Physiology 543. APS PRESIDENT’S SYMPOSIUM SERIES: RESEARCH ADVANCES IN SEX/GENDER AND DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES APS NOBEL PRIZE AWARD LECTURE Lecture Wed. 4:45 pm—McCormick Place Convention Center, W375A

4:45

9:00 9:30

546. ORGANELLE DYSFUNCTION IN PULMONARY VASCULAR DISEASE: MITOCHONDRIA, ENDOPLASMIC RETICULUM, LYSOSOMES AND BEYOND

Sex Differences and Women’s Health

Featured Topic

Hypertension

(Sponsored by: Respiration Section) Wed. 8:00 am—McCormick Place Convention Center, W196C

The Road to Stockholm: A Nobel Mission. Louis Ignarro. UCLA Sch. of Med.

Chaired: L. Shimoda and J.R. Sheak

544. THE MODULATION OF AGING THROUGH ALTERED PROTEOSTASIS

Energy Homeostasis Injury Repair and Regeneration

Symposium (Cosponsored by: The Physiological Society and Journal of Physiology) Wed. 8:00 am—McCormick Place Convention Center, W196B Chaired: B. Miller 8:00

ER Proteostasis and Aging: Insights from Long-Lived Mutant Mice. Colin Selman. Univ. of Glasgow. 8:30 Evidence for Mitochondrial Proteostasis as a Shared Characteristic of Slowed Aging. Karyn Hamilton. Colorado State Univ. 9:00 Role of Nerve-Muscle Interactions and ROS in Regulation of Muscle Proteostasis with Aging. Aphrodite Vasilaki. Univ. of Liverpool. 9:30 Mitophagy’s Role in Maintaining Mitochondrial Proteostasis and Metabolic Health. Josh Drake. Univ. of Virginia.

545. ENVIRONMENTAL, MICROENVIRONMENTAL AND NANOENVIRONMENTAL FACTORS WHICH DRIVE LIVER DISEASE PATHOGENESIS AND PROGRESSION Symposium (Cosponsored by: GI and Liver Physiology Section and AJP–Gastrointestinal and Liver Physiology) Wed. 8:00 am—McCormick Place Convention Center, W194B Chaired: M.T. Pritchard Genetics, Epigenetics, MicroRNA 8:00 8:30

176

Adenosine-Mediated Regulation of Liver Tissue Repair and Regeneration. Michel Fausther. University of Arkansas for Medical Sciences. Role of miRNA17-92 in Liver Injury. Laura Schrum. Carolinas HealthCare System Cannon Research Center.

Circadian Alterations in Alcoholic Liver Disease. Shannon Bailey. University of Alabama at Birmingham. Role of the Hemostatic System in Experimental Liver Fibrosis. James Luyendyk. Michigan State University.

Inflammation/Immunity 8:00

Targeting the Mitochondria in Pulmonary Hypertension. Evangelos Michelakis. University of Alberta. 8:30 PKCβ Signals Through Mitochondrial Reactive Oxygen Species Production in Pulmonary Arterial Smooth Muscle Cells of Neonatal Rats. J.R. Sheak, N.L. Jernigan, B.R. Walker, T.C. Resta. University of New Mexico. (1073.7) 8:45 Mitochondrial Hsp90 exerts pro-survival functions in Pulmonary Arterial Hypertension. O. Boucherat, S. Breuils-Bonnet, S. Chabot, J. Meloche, G. Vitry, C. Lambert, V. Nadeau, E. Tremblay, G. Sutendra, E. Michelakis,Y. Chae, D. Altieri, R. Paulin, S. Provencher, S. Bonnet. IUCPQ Research Centre, Canada, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada, Laval University, Canada, University of Alberta, Canada, and The Wistar Institute. (1073.10) 9:00 Apoptosis in Pulmonary Hypertension Is Regulated by the Sodium-Hydrogen Exchanger. J. Huetsch, X. Yun, K. Suresh, H. Jiang, L. Shimoda. Johns Hopkins SOM. (1073.3) 9:15 TNFα Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells. J.Q. Yap, P. Delmotte, G.C. Sieck. Johns Hopkins University and Mayo Clinic. (726.4) 9:30 Sodium-Coupled Neutral Amino Acid Transporter SNAT2 Counteracts Edema Formation and Reduces Autophagy and Er Stress in Acute Lung Injury. S. Weidenfeld, C.J. Chupin, S. Rozowsky, W.M. Kuebler. Keenan Research Centre for Biomedical Science, St. Michael´s Hospital, Canada, Charité-Berlin, Germany and University of Toronto, Canada. (725.4) 9:45 Conditioned Media from Keratinocyte Growth Factor Modified Mesenchymal Stromal Cells Reduces Pulmonary Vascular Permeability. S. Pati, R. Croze, S. Gibb, D. Potter, X. Fang, M.A. Matthay. Blood Systems Research Institute, University of California at San Francisco. (1073.9)

WEDNESDAY PHYSIOLOGY

547. GLIAL CELL DEVELOPMENT, MIGRATION, AND PATHOPHYSIOLOGY

8:22

Symposium (Sponsored by: Cell and Molecular Physiology Section) Wed. 8:00 am—McCormick Place Convention Center, W192B

8:37

Chaired: K. Gagnon and H. Sontheimer Neurophysiology

8:52

Neurobiology 8:00 8:30

Inhibiting Glial Tumor Release of Glutamate Prevents Brain Tumor Malignancy. Harald Sontheimer. Virginia Tech. Glial Migration across Transition Zones. Sarah Kucenas. University of Virginia. Genetic Analysis of Glial Development and Function in Zebrafish. William Talbot. Stanford University. Micro-environmental Regulation of Glial Cells in Spinal Cord Injury. Sohelia Karima. University of Manitoba Max Rady College of Medicine.

9:00 9:30

548. NON-MOTOR DYSFUNCTIONS IN PARKINSON’S DISEASE Symposium (Sponsored by: CNS Section) Wed. 8:00 am—McCormick Place Convention Center, W193

9:07

9:22 9:52

550. MECHANISMS PRESERVING BREATHING STABILITY Symposium

Chaired: R.A. Travagli 8:00 8:40 9:20

Chaired: J. Watters and K. Braegelmann Neurophysiology Physiology of Extreme Environments Neurobiology 8:00 8:30

(Sponsored by: Environmental and Exercise Physiology Section)

9:00

Chaired: C. Minson and S.A. Romero Physiology of Extreme Environments

8:07

Wed. 8:00 am—McCormick Place Convention Center, W190B

Featured Topic

Wed. 8:00 am—McCormick Place Convention Center, W192A

8:00

(Sponsored by: Respiration Section)

Modeling Non-Motor Aspects of Parkinson’s Disease in Alpha-Synuclein Overexpressing Mice. MarieFrancoise Chesselet. UCLA. Gastrointestinal Dysfunctions in Parkinsons Disease. R Travagli. Penn State College of Medicine. The Heart of Parkinson’s Disease: Neurocardiologic Abnormalities and Their Relationships with Other Non-Motor Aspects. David Goldstein. NINDS, NIH.

549. EXPLOITING ENVIRONMENTAL STRESSORS TO IMPROVE HEALTH AND PERFORMANCE

Combined Effects of Remote Ischemic Preconditioning and Aerobic Exercise on Sympathetic and Cerebrovascular Responses: A Novel Adaptation of Blood Flow Restriction Exercise. J. Sprick, H. Colby, C.A. Rickards. University of North Texas Health Science Center. (1086.1) Alterations of Mitochondrial Function and Metabolism in Skeletal Muscle, Liver, and White Adipose: Early Evidence for the Lactation Reset Hypothesis. H.W. Hyatt, Y. Zhang, W.R. Hood, A.N. Kavazis. Auburn University. (1086.7) Effects of Gravity and Lower Body Negative Pressure on Intracranial Pressure: Implications for Astronauts and Patients on Earth. L.G. Petersen, A. Hargens, J. Petersen, A. Cyron, M. Juhler. University of Copenhagen, Denmark, University of California, San Diego, Rigshospitalet and University of Copenhagen, Denmark. (1086.3) Mild Heat Pretreatment and Serum from Sedentary Humans Subjected to Passive Heat Therapy Protect Endothelial Cells Against Stress from HypoxiaReoxygenation. V.E. Brunt, K.W. Needham, L.N. Comrada, C.T. Minson. University of Oregon and University of Colorado Boulder. (1086.2) Game Changing Applications of Hypoxia: Beyond Altitude Training. Benjamin Levine. UT Southwestern Medical Center. Closing Remarks. Christopher Minson. Univ. of Oregon.

9:30

Coordination of Breathing and Swallowing. Emily Plowman. University of Florida. Fatal Instabilities in Cardio-Respiratory Control during a Critical Period of Development. Peter MacFarlane. Case Western Reserve University. Ventilatory Pattern Variability Following Acute Lung Injury: Insights into Central Mechanisms. Frank Jacono. Case Western Reserve University. Inactivity-Induced Phrenic Motor Facilitation Stabilizes Breathing in Rats. Tracy Baker. University of Wisconsin-Madison.

Opening Remarks. Steven Romero. Univ. of Texas Southwestern Med. Ctr. Heat Therapy Alters the Expression of Myogenic and Angiogenic Factors and Accelerates Functional Recovery Following Exercise-Induced Muscle Damage in Humans. K. Kim, Y. Nie, D. Boersma, Q. Song, S. Kuang, T. Gavin, B. Roseguini. Purdue University. (1086.4)

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PHYSIOLOGY WEDNESDAY

551. SATELLITE CELLS: EXTERNAL AND SYSTEMIC INFLUENCES

9:45

Featured Topic (Sponsored by: Muscle Biology Group) Wed. 8:00 am—McCormick Place Convention Center, W196A

553. CENTRAL AND PERIPHERAL MECHANISMS REGULATING BODY WEIGHT AND GLUCOSE HOMEOSTASIS

Chaired: N. Brooks and E. Dupont-Versteegden

Featured Topic

Muscle Metabolism 8:00 Introduction. Esther Dupont-Versteegden. Univ. of Kentucky. 8:20 The Regulation of Muscle Satellite Cells during Stress and Aging. Andrew Brack. University of California, San Francisco. 9:00 Satellite Cell Activation by Voluntary Wheel Running Is Associated with Improved Recovery from Muscle Disuse in Mice. M.J. Brooks, J.S. Mohamed, S.E. Alway. West Virginia University School of Medicine. (1082.9) 9:15 The Impact of Disuse Muscle Atrophy on Perivascular Stem Cell Quantity and Function. M.R. Munroe, M.C. Dyle, C.M. Adams, M.D. Boppart. University of Illinois at Urbana-Champaign and University of Iowa. (1082.8) 9:30 Implantable Biomimetic Niche for Satellite Cell Transplantation. Y.C. Jang, W. Han, E. Shin, A. Garcia. Georgia Institute of Technology. (1082.1) 9:45 PYY Regulates Human Skeletal Muscle Progenitor Cell Proliferation. B.J. Gheller, H.A. Roman, A.E. Thalacker-Mercer. Cornell University. (1082.7)

552. MITOCHONDRIAL PHYSIOLOGY IN CARDIOVASCULAR DISEASE Featured Topic (Sponsored by: Cardiovascular Section)

(Sponsored by: Endocrinology and Metabolism Section) Wed. 8:00 am—McCormick Place Convention Center, W192C Chaired: A. Zsombok Energy Homeostasis 8:00 8:30 9:00

9:15 9:30

9:45

Wed. 8:00 am—McCormick Place Convention Center, W190A Chaired: J. Calvert and J. Elrod 8:00

Mitochondrial Calcium Exchange in Cardiac Physiology and Disease. Jonathan Lederer. University of Maryland. 8:45 Malignant Hyperthermia-Associated Mutation of RyR1 Induces mitochondrial Ca2+ Overload in the Cardiomyocytes. J. O-Uchi, J. Mishra, B. Jhun, S. Sheu. Rhode Island Hospital, Brown University and Thomas Jefferson University. (1080.5) 9:00 Myocardin Regulates Mitochondrial Calcium Homeostasis and Prevents Permeability Transition in Cardiac Myocytes. J. Gordon, W. Mughal, J. Field, Y. Hai, D. Chapman, R. Keijzer, S. Rattan, I. Dixon, J. Huang, M. Parmacek. University of Manitoba, Canada and University of Pennsylvania. (1080.6) 9:15 Mitochondria-Derived Small Non-Coding RNAs in Extreme Anoxia Tolerance. C.L. Riggs, J.E. Podrabsky. Portland State University. (1080.2) 9:30 Gcn5l1 Promotes Enhanced Cardiac Fatty Acid Oxidation Through Acetylation of Mitochondrial Proteins. D. Thapa, M. Zhang, D.A. Guimarães, M.W. Stoner, R.M. O’Doherty, S. Shiva, I. Scott. University of Pittsburgh. (1080.3)

178

The Role of Autophagy in Aged Cardiomyocyte Arrhythmogenesis. K.R. Murphy, Y. Lu, J. O-Uchi, D. Terentyev, G. Koren. Brown University and Lifespan. (1080.4)

Developmental Actions of Leptin on CNS Pathways Involved in Body Weight and Glucose Regulation. Sebastien Bouret. University of Southern California. The Role of Central Lipid Sensing in the Regulation of Hepatic Metabolism. Kimberley Bruce. University of Colorado School of Medicine. Hepatic Sympathetic Denervation Reduces NonAlcoholic Fatty Liver Disease in Diet-Induced Obese Mice. C. Hurr, H. Simonyan, C.N. Young. George Washington University and School of Medicine and Health Sciences. (1089.6) Contribution of POMC and AgRP Neurons to the Control of Metabolic Autonomic Nerve Activity by Leptin. B. Bell, D. Morgan, K. Rahmouni. The University of Iowa. (1089.2) Angiotensin-II Type 1a Receptor Present in Insulin Producing cells is Essential for Normal Islet Function. H. Chodavarapu, J. Xu, E. Lazartigues. Louisiana State University Health Sciences Centre. (1089.9) Skeletal Muscle Integrin-Linked Kinase Contributes to Adipose Tissue Fibrosis and Adipogenesis in Diet-Induced Obese Mice. D. Lark, I. Williams, L. Kang, S. Shakir, C. Hughey, R. Zent, A. Pozzi, D. Wasserman. Vanderbilt University and University of Dundee, United Kingdom. (1089.8)

554. THE IMPACT OF EXOSOMES ON MUSCLE ATROPHY, HYPERTROPHY AND MYOGENESIS Symposium (Sponsored by: Integrative Physiology Symposium Series) Wed. 8:00 am—McCormick Place Convention Center, W375A Chaired: X.H. Wang and W.E. Mitch 8:00

Skeletal Muscle Exosome Responses to Acute and Chronic Exercise. Timothy Gavin. Purdue Univ. 8:30 Perpl-Exosomes: Elucidating the Complexity of Exosomes Released during Muscle Atrophy. Matthew Hudson. Temple Univ. 9:00 Satellite Cell-Derived Exosomes Regulate Skeletal Muscle Extracellular Matrix Remodeling during Muscle Hypertrophy. Christopher Fry. Univ. of Texas Med. Branch. 9:30 Muscle-Kidney Crosstalk through Exosome. Xiaonan Wang. Emory Univ.

WEDNESDAY PHYSIOLOGY

555. NEURAL CONTROL OF THE HEART: NEW TOOLS, NEW MECHANISMS Featured Topic

10:30

556. SEXUAL DIMORPHISM, PLASTICITY AND GENOMIC DIVERSITY OF THE PARAVENTRICULAR NUCLEUS

(Sponsored by: Neural Control and Autonomic Regulation Section)

Symposium

Wed. 10:30 am—McCormick Place Convention Center, W193

Experimental Physiology

(Sponsored by: The Physiological Society—UK)

Chaired: M. Chapleau and R.A. Larson

Wed. 10:30 am—McCormick Place Convention Center, W196A

Neurophysiology

Chaired: G.L. Yosten and W.K. Samson

Neurobiology

Sex Differences and Women’s Health

Role of Acid-Sensing Ion Channels in Cardiac Sensory Neurons. Christopher Benson. University of Iowa. 11:00 Potent Blood Pressure Lowering Effect of Optogenetic Stimulation of “Angiotensin-Sensitive” Neurons Within the Nodose Ganglion. G.B. da Silva Souza, E.B. Bruce, H. Hiller, M.D. Smeltzer, Y. Tan, I.V. Brandi, C. Sumners, M.K. Raizada, E.G. Krause, A.D. de Kloet. University of Florida. (1071.1) 11:15 At1 Receptor on Glutamatergic Neurons Regulate Cardiac Function Through Modulation of Excitability and Sympathetic Outflow. J. Xu, A. Molinas, A. Zsombok, E. Lazartigues. LSUHSC-New Orleans and Tulane University School of Medicine. (1071.2) 11:30 Altered Regulation of Cardiac Sympathetic Nerve Activity During Hypertension. R. Ramchandra, F. McBryde, B. George, J.F. Paton, D. Mahesh. The University of Auckland, New Zealand and University of Bristol, United Kingdom. (1071.4) 11:45 Transcriptomic Analysis of the Stellate Ganglion After MI. R. Bayles, A. Olivas, R. Gardner, J. Burchard, B. Habecker. Oregon Health & Science University. (1071.5) 12:00 Reliability of Heart Rate Variability as an Assessment of Cardiac Sympathetic Activity in Humans. T.R. Wakeham, I.T. Fonkoue, J.J. Durocher, W.H. Cooke, J.R. Carter. Michigan Technological University and University of Texas at San Antonio. (1071.6) 12:15 Newborn Body Fatness and Autonomic Function: Identification of Infants at Risk of Later Cardiovascular Disease. H. Dissanayake, R. McMullan, M. Phang, A. Gordon, J. Hyatt, C. Rains-Greenow, D. Celermajer, J. Polson, M. Skilton. Sydney Medical School, University of Sydney, Australia, Boden Institute, Australia, Royal Prince Alfred Hospital, Australia and Bosch Institute, Australia. (1071.8)

10:30 Transcriptomic Responses. Alastair Ferguson. Queens Univ. 11:00 Stress Induced Sexually Dimorphic Plasticity in the Paraventricular Nucleus. Jaideep Bains. Univ. of Calgary. 11:30 Sex Differences in Fluid Balance. Jessica Santollo. Univ. of Kentucky. 12:00 Sex-Dependent Factors Regulating Pressure and Flow. Jill Barnes. Univ. of Wisconsin.

557. COMPARATIVE PERSPECTIVES ON HYPOXIA SIGNALING AND TOLERANCE

W E D

Featured Topic (Sponsored by: Comparative & Evolutionary Physiology Section) Wed. 10:30 am—McCormick Place Convention Center, W190B Chaired: G.R. Scott Physiology of Extreme Environments Oxygen Transport 10:30 Human and Animal Adaptation to Hypoxia: Lessons from High Altitude. Gabriel Haddad. University of California San Diego. 11:00 High-Altitude Adaptation and Hypoxia Signaling in Deer Mice. G.R. Scott, C.M. Ivy, K.B. Tate, J.P. Velotta, R.M. Schweizer, Z.A. Cheviron. McMaster University, Canada, Truman State University and University of Montana. (1075.2)

179

PHYSIOLOGY WEDNESDAY 11:15 HIF-1 Plays a Key Signaling Role in Physiological Responses to Acute Hypoxia in the African Naked Mole Rat, Heterocephalus glaber. M.E. Pamenter. University of Ottawa, Canada and University of Ottawa Brain and Mind Research Institute, Canada. (1075.3) 11:30 Reactive Oxygen Species Signaling in the HypoxiaTolerant Turtle and Goldfish Stellate and Pyramidal Neurons Is Species Specific. L. Buck, N. HossienJavaheri, V. Pillai, P. Hawrysh. University of Toronto, Cell and Systems Biology, Canada and University of Toronto, Canada. (1075.5) 11:45 Comparative Physiology of Hypoxia Tolerance in Intertidal Sculpins. J. Richards, G. Lau. The University of British Columbia, Canada. (1075.7) 12:00 A Paradigm Shift: Benefits of Carbon Monoxide (CO) in Hypoxia-Adapted Species. M.S. Tift, P. Jordan, T. Lueker, P. Cabrales, T. Simonson, E. Heinrich, F. Villafuerte, J. Meir, D.E. Crocker, B. Moore, J. St. Leger, P.J. Ponganis. Scripps Institution of Oceanography, University of California, San Diego, Universidad Peruana Cayetano Heredia, NASA, Sonoma State University and SeaWorld. (719.16) 12:15 From Field to Lab: Asking Questions About Hypoxia Regulation of Vascular Tone in Cell Culture Systems. A. Hindle, K. Allen, A. Batten, L. Wareham, E. Buys, W. Zapol. Massachusetts General Hospital and Colorado State University. (1075.1)

558. KICK START YOUR FUNDING: LOOKING BEYOND NIH AND NSF Symposium

Symposium (Sponsored by: Translational Physiology Interest Group) Wed. 10:30 am—McCormick Place Convention Center, W192A Chaired: L.E. de Castro Brás and G.V. Halade Injury Repair and Regeneration 10:30

Small Molecules and Their Signaling Mechanisms on Heart Failure. Burns Blaxall. Cincinnati Children’s Hospital Medical Center. 11:00 Defining the Roles of Molecular Resolving and NonResolving Mediators in Heart Failure Pathology. Vasundhara Kain. The University of Alabama at Birmingham. 11:30 ECM-Generated Peptides Function in Post-MI Remodeling. Merry Lindsey. University of Mississippi Medical Center. 12:00 Mitochondria-Targeting Peptides in Heart Disease. David Brown. Virginia Tech.

560. BLOOD DOPING: PHYSIOLOGY, PHARMACOLOGY AND DETECTION CHALLENGES Symposium (Cosponsored by: Environmental and Exercise Physiology Section and Journal of Applied Physiology)

(Sponsored by: Trainee Advisory Committee)

Wed. 10:30 am—McCormick Place Convention Center, W196C

Wed. 10:30 am—McCormick Place Convention Center, W192C

Chaired: L. Bowers

Chaired: J. Steiner and K. Streeter

Oxygen Transport

10:30 Seeking Funding Outside the Norm: Unique Opportunities within Military Research Programs. Lisa Leon. Thermal Mountain Medicine Division. 11:00 Successfully Securing Funding and Collaborating with industry. Wai Man (Eugene) Shek. Lilly China Research and Development Co., Ltd. 11:30 Cancer Funding from a Private Foundation. Charles Saxe. The American Cancer Society. 12:00 Crowd Funding Your Science. Melissa Wilson Sayres. Arizona State Univ.

180

559. PEPTIDES AND METABOLITES IN CARDIOVASCULAR DISEASE

10:30 Current Status of Hematological Manipulation and Detection in Sport. Larry Bowers. US AntiDoping Agency. 10:50 Physiology of Blood Doping and Challenges. Yorck Schumacher. Aspetar Orthopaedic and Sports Medicine Hospital. 11:10 Pharmacology of Erythropoiesis Stimulating Agents. Steve Elliott. Newbury Park, CA. 11:30 Athlete Biological Passport, Detection Methods and Complementary Biomarkers. Daniel Eichner. Sports Medicine Research Testing Laboratory. 11:50 Red Blood Cell Population Dynamics and Individualized Modeling. John Higgins. Massachusetts General Hospital.

WEDNESDAY PHYSIOLOGY

561. NEW INSIGHTS INTO THE REGULATION OF RENAL BLOOD FLOW IN HEALTH AND DISEASE Symposium (Sponsored by: Renal Section) Wed. 10:30 am—McCormick Place Convention Center, W194B Chaired: A. Polichnowski and J. Williams Microbiome Hypertension Salt 10:30

The Physiological Significance of TGF Response in the Long-Term Control of Sodium Excretion and Blood Pressure. Ruisheng Liu. University of South Florida. 11:00 ROS Differentially Regulate Myogenic Tone. Chris Wilcox. Georgetown University Medical Center. 11:30 The Role of NADPH Oxidase Subunit p67phox in the Regulation of Renal Function in Dahl S Rats. Louise Evans. Medical College of Wisconsin. 12:00 Renal Autoregulation and Dynamics of Glomerular BP Transmission in Conscious Rats: Novel Analysis Methods and Insights. Karen Griffin. Loyola University.

562. INFLAMMATION AND IMMUNITY AND HEART DISEASE Featured Topic

11:30

Efficacy of Tolerizing Vaccination Strategy for Mitigating Autoimmune-Mediated Cardiac Injury. R.M. Lust, S.P. Reece, M.R. Van Scott, M.D. Mannie. East Carolina University and Brody School of Medicine. (1079.2) 11:45 Administration of Anti-Inflammatory Interleukin-37 Ameliorates Age-Related Vascular, Metabolic and Physical Dysfunction in Mice. Z.J. Sapinsley, D.B. Ballak, V.E. Brunt, M.C. Zigler, R.A. Gioscia-Ryan, J.J. Richey, C.A. Dinarello, D.R. Seals. University of Colorado Boulder, University of Colorado Denver and Radboud University Medical Center, Netherlands. (1079.3) 12:00 CXCL4 Aggravates Cardiac Dilation and Mortality After Myocardial Infarction by Inducing ProInflammatory M1 Macrophages and Inhibiting Macrophage Phagocytosis. M.L. Lindsey, M. Jung, A. Yabluchanskiy, P.L. Cannon-Stewart, R.P. Iyer, E.R. Flynn, K.Y. DeLeon-Pennell, Y. Ma. University of Mississippi Medical Center. (1079.4) 12:15 Inhibition of Allograft Inflammatory Factor-1 Attenuates B Cell Development and Infiltration to Cardiac Tissue During the Development of Diabetic Cardiomyopathy. A. Sarkar, S.K. Shukla, K. Sikder, A.Y. Tsygankov, K. Rafiq. Thomas Jefferson University and Temple University. (1079.5)

563. MIRNA REGULATION OF THE MITOCHONDRION IN CARDIOVASCULAR DISEASE Symposium

(Sponsored by: Cardiovascular Section)

(Cosponsored by: Cardiovascular Section and AJP–Heart and Circulatory Physiology)

Wed. 10:30 am—McCormick Place Convention Center, W190A

Wed. 10:30 am—McCormick Place Convention Center, W196B

Chaired: G. Halade and E. Thorp

Chaired: J. Hollander and D. Thapa

Inflammation/Immunity

Genetics, Epigenetics, MicroRNA

10:30 Cardiac Macrophages in Steady-State and Disease. Matthias Nahrendorf. Harvard Medical School. 10:50 Myeloid Cells and Cardiac Repair. Jean-Sebastien Silvestre. INSERM UMRS 970 11:15 Identification of Inflammatory Biomarkers for Hypertension From Isolated Human Monocytes. A.E. Norlander, C.L. Galindo, F. Elijovich, C.L. Laffer, K.R. Montaniel, J.S. Gnecco, M.S. Madhur. Vanderbilt University. (1079.1)

10:30 MiRNA Regulation of the Mitochondrial Genome: Impact of Diabetes Mellitus. John Hollander. West Virginia University. 11:00 MitomiRs: a New Player in Cardiovascular Health. Samarjit Das. Johns Hopkins University. 11:30 MiRNAs in Ischemic Injury: A Role for Mitophagy. Roberta Gottlieb. Cedars-Sinai Hospital. 12:00 Impact of Anti-miR Strategies on Macrophage Mitochondria and the Development of Atherosclerosis. Katy Rayner. University of Ottawa.

181

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PHYSIOLOGY WEDNESDAY

564. CARDIOVASCULAR CONTROL AFTER NEUROLOGICAL INJURY

565. MECHANISMS OF HYPERTENSION RISK Symposium

Featured Topic

(Sponsored by: Water and Electrolyte Homeostasis Section)

(Supported by Vancouver Coastal Health Res. Inst.)

Wed. 2:30 pm—McCormick Place Convention Center, W196B

(Sponsored by: Cardiovascular Section) Wed. 10:30 am—McCormick Place Convention Center, W192B Chaired: A.A. Phillips and C.R. West

2:30

Neurophysiology

3:00

Neurobiology 10:30 Cardiovascular Control after Spinal Cord Injury. Andrei Krassioukov. International Collaboration on Repair Discoveries. 11:00 Heart Rate and Blood Pressure Responses to Head-Up Tilt Following Autonomic Blockade in Persons with SCI and Intact Controls. J.M. Wecht, J.P. Weir, N. Nhuquynh, G.J. Schilero, W.A. Bauman. James J Peters VA Medical Center, Icahn School of Medicine, Mount Sinai and University of Kansas. (1077.8) 11:15 Left Ventricular Contractile Function Is Critically Dependent on Descending Sympathetic Control and Can Be Restored with Minocycline After Spinal Cord Injury. J.W. Squair, J. Liu, R. Gopaul, A.V. Krassioukov, C.R. West. University of British Columbia, Canada and GF Strong Rehabilitation Centre, Canada. (1077.5) 11:30 Heat Exposure Improves Cognitive Performance in Persons with Higher Levels of Spinal Cord Injury. J.P. Handrakis, T.D. Tittley, O.F. Tascione, J. Bart, C. Barton, C. Bang, A.M. Spungen, W.A. Bauman. James J Peters Veterans Affairs Medical Center, New York Institute of Technology, School of Health Professions, James J. Peters VA Medical Center and Icahn School of Medicine at Mount Sinai. (1077.10) 11:45 A Triple Combination Approach Involving Nerve Transplantation, Glial Scar Digestion and Passive Exercise Promotes Cardiovascular Recovery After Spinal Cord Injury. R. Sachdeva, R. Gopaul, M. Jia, A. Monga, M. Ramer, A.V. Krassioukov. University of British Columbia, Canada. (1077.7) 12:00 Chronic, Complete Cervical6–7 Cord Injury: Distinct Autonomic, Cardiac and Vascular Deficits. H.L. Lujan, R.A. Mulder, S.E. DiCarlo. Wayne State University School of Medicine. (1077.6) 12:15 Passive Leg Cycling Comprehensively Restores Cerebrovascular Health After Experimental High-Thoracic Spinal Cord Injury. M. Jia, A.A. Phillips, N. Matin, A. Yung, M. Zheng, A. Lee, A. Monga, P. Kozlowski, A. Dorrence, A.V. Krassioukov. University of British Columbia, Canada, Michigan State University and G.F. Strong Rehabilitation Centre, Canada. (1077.13)

182

Chaired: C. De Miguel and J. Abais-Battad

3:30 4:00

Pre-Eclampsia and Hypertension Risk Later in Life. Jennifer Sasser. Univ. of Mississippi Med Ctr. T Regulatory Cells and Sex Differences in Hypertension Risk. Jennifer Sullivan. Augusta Univ. SCFAs, Microbiome and Hypertension Risk. Jennifer Pluznick. Johns Hopkins Medical School. Histone Deacetylases, NO and Hypertension Risk. Jennifer Pollock. Univ. of Alabama at Birmingham.

566. PATENT FORAMEN OVALE: THE HOLE STORY ENVIRONMENTAL AND EXERCISE PHYSIOLOGY Symposium (Sponsored by: Environmental and Exercise Physiology Section) Wed. 2:30 pm—McCormick Place Convention Center, W190B Chaired: A. Lovering and P. Wilmshurst 2:30 3:00 3:30 4:00

PFO: The “Hole” Story of Thermoregulation. James Davis. Indiana State University. PFO: The “Hole” Story of Hypoxia/Altitude. Glen Foster. Univ. of British Colubmia-Okanagan. PFO: The “Hole” Story of Exercise. Brett Fenster. National Jewish Health. PFO: The “Hole” Story of Diving. Peter Wilmshurst. Royal Stoke University Hospital.

567. NEW INSIGHTS INTO EPITHELIAL TRANSPORT: APPLICATION OF GENETIC MODELS Featured Topic (Sponsored by: Epithelial Transport Group) Wed. 2:30 pm—McCormick Place Convention Center, W192A Chaired: T. Rieg and R. Fenton 2:30

2:45

Chronic Loop Diuretic Treatment Mediates SegmentSpecific Hypertrophy in the Nephron. A. Krauson, E. Walczak, S. Iyer, N. Velarde, J. Nizar, V. Bhalla. Stanford University and BD Genomics. (857.12) Intestinal Adenylyl Cyclase 6 Mediates Cholera ToxinInduced Diarrhea.T. Rieg, I. Kaji,Y. Akiba, J. Kaunitz, S.B. Poulsen, J.A. Dominguez Rieg, R.A. Fenton. UCSD & VASDHS, UCLA & Greater LAVAHS, Aarhus University, Denmark and Bastyr University California. (703.3)

WEDNESDAY PHYSIOLOGY 3:00

3:15

3:30

3:45

4:00 4:15

AngII Hypertension Differentially Influences Sodium Transporters, Channels and Claudins in Female vs. Male FVB/N Mice. J.S. Manwani, K.M. Mirabito Collafella, D.L. Ralph, K.M. Denton, A.A. McDonough. Keck School of Medicine of USC, Cardiovascular Program, Monash Biomedicine Discovery Institute, Monash University, Australia and Erasmus Medical Center, Netherlands. (1007.54) Dual PDE3/4 Inhibition Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. M.A. Borchart, D.L. Gumina, T.A. Kronk, J.H. Sim, M.A. Blount. Emory University School of Medicine. (1007.57) The Protective Role of NHERF1 in Cisplatin-Induced Acute Kidney Injury. A.M. Bushau-Sprinkle, A.R. Sherwood, C.A. Conklin, M.T. Barati, T. Dupre, L. Siskind, K.B. Gagnon, S.J. Khundmiri, E.D. Lederer. University of Louisville, Howard University and Robley Rex Veteran Affairs Medical Center. (694.1) Blockade of AT2R Causes Hyperkalemia by Stimulating the Basolateral Kir4.1 and Apical NCC in the Distal Convoluted Tubule (DCT). P. Wu, Z. Gao, M. Wang, X. Su, D. Lin, W. Wang. New York Medical College, Medical College of Xiamen University, People’s Republic of China. (1007.23) A Cyclic-AMP Dependent Pathway Regulates Intestinal Oxalate Secretion. J. Whittamore, M. Hatch. University of Florida. (1007.30) Deletion of Xenotropic and Polytropic Retrovirus Receptor 1 in Mouse Nephron Causes Renal Fanconi Syndrome and Hypophosphatemic Rickets. C. Ansermet, M. Moor, G. Centeno, M. Auberson, D. Hu, R. Barron, S. Nikolaeva, B. Haenzi, N. Katanaeva, I. Gautschi, V. Katanaev, S. Rotman, R. Koesters, L. Schild, S. Pradervand, O. Bonny, D. Firsov. Université de Lausanne, Switzerland, Harvard School of Dental Medicine, Institute of Evolutionary Physiology and Biochemistry, Russian Federation, University Hospital of Lausanne, Switzerland and Université Pierre et Marie Curie, France. (857.9)

568. FIGHTING THE FAT: LIFESTYLE APPROACHES TO PROTECT AGAINST ADIPOSE TISSUE AND LIVER DYSFUNCTION Symposium

4:00

569. NOVEL IMAGING TECHNOLOGIES IN REPRODUCTIVE PHYSIOLOGY Symposium (Supported by Fujifilm VisualSonics, Inc.) (Sponsored by: Endocrinology and Metabolism Section) Wed. 2:30 pm—McCormick Place Convention Center, W193 Chaired: L.M. Yamaleyeva and S.H. Lindsey 2:30 3:00 3:30

4:00

Symposium (Sponsored by: Translational Physiology Interest Group) Wed. 2:30 pm—McCormick Place Convention Center, W196A Chaired: P. Kleinbongard and K. Ait-Aissa 2:30 2:55

3:20

Chaired: D. Wright 2:30 3:00 3:30

Turn Down the Burn: How Exercise can Protect Against Liver and Adipose Inflammation. Daivd Wright. Univ. of Guelph. Heat Shock Proteins in the Treatment and Prevention of Disregulated Adipose and Liver Metabolism. Paige Geiger. Univ. of Kansas Med. Ctr. Managing Nonalcoholic Fatty Liver Disease: Are All Lifestyle Interventions Created Equal. R. Rector. Univ. of Missouri, Columbia.

Placenta Imaging Project: Using MRI to Understand Development. Antonio Frias. Oregon Health and Science University. Placental Vascular Patterning in the Mouse: Relating Hemodynamics to Vascular Architecture. John Sled. University of Toronto. Contrast Enhanced Ultrasound/Microbubble Technology for Targeted Delivery of Genes and Quantification of Microvessel Flow in the Primate. Gerald Pepe. Eastern Virginia Medical School. Photoacoustic Imaging for in vivo Quantification of Placental Oxygenation. Liliya Yamaleyeva. Wake Forest School of Medicine.

570. VASODILATION IN HUMAN MICROVESSELS: FROM BED TO BENCH AND BACK

(Sponsored by: Endocrinology and Metabolism Section) Wed. 2:30 pm—McCormick Place Convention Center, W192B

Maternal Phytosterol Supplementation to a High Cholesterol Diet Modulates Hepatic Lipid Response in Offspring of ApoE Deficient Mice. Todd Rideout. SUNY Univ. at Buffalo.

3:45 4:10

Vascular Effects of Exercise and Other Lifestyle Factors in Humans. Shane Phillips. University of Chicago at Illinois. Ischemic Preconditioning as an Intervention to Improve Motor Function in Stroke Subjects: Vascular and Neural Considerations. Matt Durand. Medical College of Wisconsin. Remote Preconditioning Effect on Vasculature and Myocardium. Petra Kleinbongard. University of Essen. Healthy Aging in the Human Vasculature Contributions of External Stressors on Endothelial Function. Anthony Donato. University of Utah. Role of Autophagy in Endothelial Cell Function in Diabetics. Jessica Fetterman. Boston University School of Medicine.

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PHYSIOLOGY WEDNESDAY

571. LEPTIN BEYOND APPETITE REGULATION Symposium

573. OMICS APPROACHES TO UNDERSTANDING MUSCLE BIOLOGY

(Sponsored by: Translational Physiology Interest Group)

Symposium

Wed. 2:30 pm—McCormick Place Convention Center, W196C

(Sponsored by: Cell and Molecular Physiology Section) Wed. 2:30 pm—McCormick Place Convention Center, W194B

Chaired: P. Singh and P. Cohen 2:30 Leptin and Leptin Resistance: Implications for Cardiovascular Disease. Virend Somers. Mayo Clinic. 3:00 Mechanistic Role of Leptin in Modulating Hyperglycemia in Poorly-Controlled Diabetes. Rachel Perry. Yale University School of Medicine. 3:30 Adipose Tissue Dynamics during Weight Gain: The Leptin Story. Prachi Singh. Mayo Clinic. 4:00 Peripheral Actions of Leptin: From Metabolism to Oncogenesis. Philipp Scherer. The University of Texas Southwestern Medical Center.

572. NEW CONCEPTS OF THE RENIN-ANGIOTENSIN SYSTEM IN CARDIOVASCULAR PATHOPHYSIOLOGY Symposium

Chaired: J.G. Burniston and Y-W. Chen 2:30 DamID Profiling during Myogenesis Defines Heterochromatin Flux at the Nuclear Envelop. Jelena Perovanovic. National Institues of Health, Bethesda. 3:00 Beyond Timekeeping, the Transcriptional Landscape of the Molecular Clock in Skeletal Muscle. Karyn Esser. University of Florida. 3:30 Proteomics Insights in to Insulin Resistance in Muscle. Lawrence Mandarino. Mayo Clinic. 4:00 Metabolomics and Fluxomics Reveal Pathways underlying Enhanced Muscle Performance in Exercise. Charles Burant. University of Michigan Medical School.

574. HYDRATION AND VASOPRESSIN BEYOND THE KIDNEY

Pan-American Societies (SFiB)

2:30 3:00 3:30 4:00

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Symposium

Wed. 2:30 pm—McCormick Place Convention Center, W192C

(Supported by Danone Research)

Chaired: M.J. Campagnole-Santos and E.A. Aiello

(Sponsored by: Water and Electrolyte Homeostasis Section)

Cardioprotective Role of Angiotensin-(1-9) in the Cardiovascular System. Sergio Lavandero. Univ. of Chile and P. Univ. Catolica de Chile. Pathophysiological Role of the Aldosterone G-Protein Coupled Receptor GPER in the Heart. Alejandro Orlowski. Univ. Nacional de la Plata, Argentina. New Insights into Alamandine Signaling in Cardiac Myocytes. Silvia Guatimosim. Univ. Fed. de Minas Gerais, Brazil. Alamandina and Heart Failure. Robson Santos. Univ. Fed. de Minas Gerais, Brazil.

Wed. 2:30 pm—McCormick Place Convention Center, W190A Chaired: S. Kavouras and L. Bankir 2:30 3:00 3:30 4:00

Central Effects of Vasopressin in the Brain. Daniel Bichet. Univ. of Montreal. The Vasopressin Paradox: Not a Vasoconstrictor? Georges Bakris. Univ. of Chicago. Vasopressin as a Stress Hormone. Ivan Tack. CHU Toulouse, Hopital Rangueil. From (De)Hydration Science towards Biomarkers for Hydration for Health. Jeanne Bottin. Danone Nutricia Research.

SUNDAY, APRIL 23 Across Societies 575. COMPUTERS IN RESEARCH AND TEACHING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: 12:45 pm–3:00 pm Recognizing that techniques and issues related to teaching and the use of computers in research and teaching crosses all biomedical disciplines, EB 2017 has combined education posters from all participating societies. Please note: Posters are on display Sunday through Tuesday. Presentation time is for Sunday only. T1 575.1 Grasping the Idea: Using Hand Dynamometry to Teach the Scientific Method to Elementary Students. R. Sledge, W.J. Norris, E.K. Merritt. Appalachian State University. T3 575.2 Student-Produced Videos Enhance Learning in a Freshman Cellular and Molecular Biology Course. H. Chen, Y. Ellenbogen, M. Ng, K. Brar, J. Lee, C. Lee, B. Lee, S. Nastos. McMaster University, Canada. T5 575.3 Dynamic Modeling Shows Long-Term Gene Expression Is Highly Dependent on Macromolecular Crowding. A.R. Shim, L. Almassalha, H. Matsuda, R. Nap, I. Szleifer. Northwestern University.

576. TEACHING, LEARNING AND TESTING IN THE BIOLOGICAL AND BIOMEDICAL SCIENCES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: 12:45 pm–3:00 pm Recognizing that techniques and issues related to teaching and the use of computers in research and teaching crosses all biomedical disciplines, EB 2017 has combined education posters from all participating societies. Please note: Posters are on display Sunday through Tuesday. Presentation time is for Sunday only. T7 576.1 Team-Based Learning in the Neuroanatomy Lab of an Undergraduate Human Anatomy and Physiology Course—A Lesson Study. J. Schanandore, S. Liu, C. Schwartz, R. Stapley. University of Wisconsin-La Crosse. T8 576.2 Interactions Between Student Attitudes, Affect and Outcomes During a Transition to an Active Learning Format in Introductory Physiology. S.J. Malmquist, W.F. Collins; III. Stony Brook University.

T9 576.3 Show Them You Care: Faculty Responsiveness Augments Student Buy-In to Active Learning. X. Chen, A. Cavanagh, M. Graham. University of Connecticut and Yale University. T10 576.4 A Case Study for Teaching Neuroanatomy Structure and Function: Doctor, Why Am I So Tired and Dizzy? J.A. Stokes, A. Grosofsky. Beloit College. T11 576.5 Expanding on Case Studies: Combined Active Learning Techniques in Small Undergraduate Physiology Classrooms. C. Caldari. Centenary College of Louisiana. T12 576.6 Educating the Educators: A Unique Physiologyand Anatomy-Based Educator Workshop in the Wiregrass Region. A.A. Vasauskas, C.L. Richardson, S.A. Anderson, A.L. Robinson. Alabama College of Osteopathic Medicine. T13 576.7 Active Methodologies Improve the Performance of Medical Students in Physiology Assessments. L.H. Montrezor. T14 576.8 The Comparison of Student Performance Between Flipped Classroom and Traditional Teaching Approach. C. Gopalan, M.C. Klann. Southern Illinois University Edwardsville. T15 576.9 The Clinical Reasoning Conference: A FlippedClassroom, Case-Based Approach to Teaching and Learning in the Pre-Clerkship Medical Curriculum. R.P. Sullivan, D.J. Karras, D.R. Schwartz, G. Sterling. Lewis Katz School of Medicine at Temple University. T16 576.10 Impact of Learning Approaches on Academic Performance of Preclinical Medical Students: Superficial vs Deep. Z. Kayali, F.K. Abdulwali, A.A. Peeran, A.S. Obad, M.A. Shareef. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T17 576.11 Effectiveness of a “Semi-Flipped” Class in the Teaching of Pharmacology and Its Prerequisites. R.A. Pena Silva, D. Santamaria Rodriguez, A. Avalo Azcarate, L. Chaparro Moreno, L. Sierra Penuela, S. Jaramillo Rincon, S. Gomez Montero. Universidad de los Andes, Colombia, Clínica de Marly, Colombia and Hospital Italiano de Buenos Aires, Argentina. T18 576.12 Redesigning a Comprehensive Integrated Pharmacology Course for Active Learning in a CompetencyBased Curriculum. S.A. Marsh, M.F. Paine, K.M. Gibson. Washington State University. T19 576.13 Student Survey Results on the Integration of Active Learning Exercises in a Dental Education Self-Learning Setting. L. Ruest, K.K. Svoboda, L.A. Opperman. Texas A&M College of Dentistry. T20 576.14 Problem-Based Learning Increases Motivation and Learning Strategy Use in Both Low- and High-Achieving Students in an Upper-Level Undergraduate Physiology Course. M.K. Rhoads, L. Xiang, B.M. Franklin, J.L. Osborn. University of Kentucky and Weber State University.

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T21 576.15 Medical Students’ Perceptions of Physiology Practical Animal-Handling and Virtual Classes in ProblemBased Learning (PBL) Method. M.D. Durand, C.B. Restini, R.B. Bestetti, L.B. Couto. University of Ribeirão Preto, Brazil. T22 576.16 Early Echocardiography Experience Assists in Improving and Retaining Knowledge of Cardiac Anatomy and Physiology for Medical Students. A. Elmoselhi, M. Eladl, M. Seif. University of Sharjah, United Arab Emirates and University Hospital Sharjah, United Arab Emirates. T23 576.17 Dramatization of Starling Forces: An Interactive Learning Approach. B.W. Connor, H. Carvalho. VTCSOM. T24 576.18 Basic Integrative Disciplines in a Dentistry Course: 10 Years Evaluation of the Experience of Piracicaba Dental School of the University of Campinas, Brazil. F.K. Marcondes. Piracicaba Dental School and UNICAMP, Brazil. T25 576.19 Epistemic Cognition in Medicine: A Review of Literature and Implications for Medical Educators. J.L. Eastwood, E. Koppelman-White, M. Mi, J.A. Wasserman, E.F. Krug III, B. Joyce, B. Joyce. Burrell College of Osteopathic Medicine, Oakland University and Oakland University William Beaumont School of Medicine. T26 576.20 Vertical Integration of Basic Science and Clinical Medicine During Case Based Learning Sessions for Third Year Medical Students. S.K. ElSayed, I. Niculescu. OUWB School of Medicine and OUWB School of Medicine Beaumont Health System. T27 576.21 Clinical Research 101: A Way to Showcase Healthcare Professions in High-School Students Using PhUn Week. A.N. Gurovich, F. Morales, K. Terry. Indiana State University and South Vermillion High School. T28 576.22 Utilizing Pre- And Post-Exercise Changes in Heart Rate as a Method of Teaching the Scientific Method to Second Grade Students. J.C. Taylor, B. Mercier. Mississippi Osteopathic Medical Association and Sacred Heart Elementary School. T29 576.23 A Summer PhUn Week for English Language Learners. P.A. Halpin, R.M. Pugh. University of New Hampshire at Manchester. T30 576.24 What Are You Blubbering About? A Study of Comparative Cold Physiology. M.M. Clarke, D.H. Craighead, B.K. Alba, S.W. Shank. The Pennsylvania State University. T31 576.25 Annual PhUN Week Service Learning Events Improve Student Content Mastery and Civic Engagement. E.M. Rhinehart. Susquehanna University. T32 576.26 An Undergraduate Teaching Course: Students Learning Physiology Through Teaching. L.C. Anderson. University of Minnesota. T33 576.27 A Comparison of High Fidelity Patient Simulations and Computerized Clinical Cases on Undergraduate Student Learning of Physiology. D.M. Harris, W. Li. University of Central Florida. T34 576.28 Theory Into Practice: Investigation of the Service Learning Pedagogy in Undergraduate Physiology Education. J.M. Redden. University of Connecticut.

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T35 576.29 Does Size Really Matter? a Comparison of Class Size and Student Outcomes in Introductory Physiology Courses. C.A. Gibbons Kroeker. University of Calgary, Canada and Ambrose University, Canada. T36 576.30 A Survey of Student Preconceptions About Physiology. K.L. Walton. Missouri Western State University. T37 576.31 Building Bridges: Addressing Real World Problems with Technology But Without a Protocol Using Design Instruction in a Physiology Lab. A. Vaidyam, J.T. Batts, H. Chan, N. Pelaez. Purdue. T38 576.32 Physiology Labs at the Cutting Edge: Multidisciplinary Design of Systems and Devices for Physiology Measurements. R.H. Rozner, J.T. Batts, G.K. Nossa, C. Pullins, N. Pelaez. Purdue. T39 576.33 Course-Embedded Undergraduate Research in an Animal Physiology Laboratory Course. S. Liu. University of Wisconsin-La Crosse. T40 576.34 Introducing Informal Communication of Science Within an Undergraduate Anatomy and Physiology Course. A.M. Petzold, R. Dunbar. University of Minnesota Rochester. T41 576.35 “The Locomotion”: Not the Pop Song but an Activity Designed to Integrate Energetics and Mechanics to Understand Human Movement. S. Elmer. Michigan Tech University. T42 576.36 A Model for Enhancing Student Gains During Experiential Learning Opportunities. P.A. Halpin, A.E. Donahue, K.M. Johnson. University of New Hampshire at Manchester and Beloit College. T43 576.37 The QMRC Method: A Systematic Approach for Undergraduate Students to Understand, Analyze, and Communicate Data Figures from Primary Research Articles. K. Hinkle. Norwich University. T44 576.38 An Innovative Approach to Teaching the History of Physiology. S. Anjur. IMSA. T45 576.39 The Use of Livescribe™ Echo® Pen Recordings to Make Videos of Jeopardy-Like Questions to Encourage Spaced Out, Interleaved Study by Students. J.S. Chapman, L. Denofrio-Corrales. Heartland Community College. T46 576.40 An Analysis of Assessment Modalities in HighEnrollment Course Sections. J. Kingsbury, T. Penkrot, C.S. Lisenbee, J.K. Hyatt. Arizona State University. T47 576.41 A Comparison of Student Profiles and Performance in an Introductory Non-Majors Biology Course Offered 100% in the Classroom vs. 100% Online. M.A. Daggett. Missouri Western State University. T48 576.42 Aligning Introductory Biology to Vision and Change Recommendations. K.A. Wilkinson, S. Lambrecht, S. Anand. San Jose State University. T49 576.43 Lessons from a Hybrid Undergraduate Human Biology Course. K. Seiler. Champlain College. T50 576.44 Lessons from Fundulus Melanophores: Integrative Approach in Biology Education. S.M. Hong. University of Delaware.

T51 576.45 Factors Directing Preclinical Medical Students Toward Specialty of Choice. F.N. Shacfe, R.I. Alhomoudi, A.A. Peeran, A.I. Abdeh, A.S. Obad, M.A. Shareef. Alfaisal Unversity, Saudi Arabia, Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T52 576.46 Low Intrinsic Motivation but Not GRIT Is Predictive of Low Performing Medical Students. R.A. Augustyniak, J. Chin, H. Lujan, R.N. Cortright, S.E. DiCarlo. Edward Via College of Osteopathic Medicine- Carolinas, Wayne State University School of Medicine and East Carolina University. T53 576.47 Resource Utilization Among Students in Different Professional Programs Enrolled in the Same Human Physiology Course and Its Correlation to Exam Performance. K. LePard, C.J. Skok, K. Sondgeroth. Midwestern Unniversity. T54 576.48 Challenges with Initial Implementation of an Intelligent Formative Assessment System. E. Wilson, J.D. Kibble, C. Bellew, C. Hernandez, A. Castiglioni, A. Khan, C. Kamin, A. Riordan, S. Dauner, D. Lorens, A. Gangopadhyaya, N. Rajagopal, S. Gaglani, R. Haynes, M. Lineberry. University of Central Florida, University of Illinois at Chicago and Knowledge Diffusion Inc. T55 576.49 Inspection of Medical Students’ Quality of Life in an Unstable Nation, Yemen: Is WHOQOL-BREF Still Valid and Reliable? A.A. Ba Abbad, H.A. Alaidroos, A. Bawazir, M.A. Al-Gunaid, M.O. Al-Ghurabi, F.K. Abdulwali, A.S. Obad, M.A. Shareef. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical. T56 576.50 Investigation of Factors Impacting Medical Students’ Quality of Life Under Current Civil War in Yemen. M.O. Al-Ghurabi, M.A. Al-Gunaid, H.A. Alaidroos, A.A. BaAbbad, A.A. Bawazir, F.K. Abdulwali, M.A. Shareef, A.S. Obad. Alfaisal University, Saudi Arabia and Mercy St Vincent Medical Center. T57 576.51 The Use of a Case Study from Pop Culture Improves Student Test Scores and Evaluations in a Cardiovascular Physiology Class. R. Berg. Frederiksberg and Bispebjerg Hospitals, Denmark.

T58 576.52 Clinical Scenario Videos Improve D.M.D Students’ Perception of the Basic Sciences and Ability to Apply Content Knowledge. C.J. Metz, M.J. Metz. University of Louisville. T59 576.53 Subways and Role-Plays: Using Analogies to Understand Matter and Energy Flow. K. Hull, P. Marx, M. Jensen. Bishop’s University, Canada and University of Minnesota. T60 576.54 The Wright Cardiac Cycle Table: A Novel Tool to Teach the Cardiac Cycle. B.E. Wright. Ross University School of Medicine, Dominica. T61 576.55 Tonicity and Osmolarity, Why Are They Confusing? S.Y. Kuang. Oakland University William Beaumont School of Medicine. T62 576.56 Open Science for Medical Students: Quincke’s Research Scholarship. A.J. Dorta-Contreras, B. PadillaDocal, J.P. Martínez-Larrarte, I. Iglesias-González, L. Cárdenas-de-Baños, W. Castillo-González, C. GonzálezLosada. Labcel, Cuba. T63 576.57 Observation, Observation, Observation! Anomalies Seen and Learned from a Prosected Cadaver. C. Mullens, P.S. Klinkhachorn. West Virginia University. T64 576.58 the Story of Two Tendons and 20,000 Miles Apart: From Anatomical and Functional Perspectives in Education. P.S. Klinkhachorn, R.K. Mannan, C.L. Mullens. West Virginia University.

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Anatomy 577. FORM, FUNCTION AND MORPHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E1 577.1 Ultrastructural Analysis of the Tongue of White-Eared-Opossum (Didelphis albiventris) B.T. Schäfer, A. Teixeira Filho, I. Watanabe. University of São Paulo, Brazil and Federal University of Pelotas, Brazil. E2 577.2 Anatomical Descriptions of Developing Hypoglossal Motor Neurons in the Green Frog, Lithobates clamitans and Bullfrog, Lithobates catesbeiana Through Metamorphosis. C.W. Anderson, A.J. Carroll. Idaho State University. E3 577.3 Variation of Facial Musculature Between Wolves and Domestic Dogs: Evolutionary Divergence in Facial Movement. A. Burrows, R. Diogo, B. Waller, J. Kaminski. Duquesne University, Howard University and University of Portsmouth, United Kingdom. E4 577.4 Seriated CT-Scan of the Cranium in a Crocodylus niloticus from Madagascar (215 mm Long) in the Three Planes of the Space. P.P. Le Floch-Prigent, S. Verdeille. Université de Versailles-Saint Quentin, France and Clinique du Val d’Or, France. E5 577.5 Modeling Complex Cranial Joints in Varanus exanthematicus A.T. Wilken, K.M. Middleton, K.C. Sellers, I.N. Cost, J.L. Davis, C.M. Holliday. University of MissouriColumbia and Southern Indiana University. E6 577.6 Bending Properties of the Jugal Bone in Mallard Ducks and Its Significance for Cranial Biomechanics. C.J. Smith, C.M. Holliday, K.M. Middleton, A.M. Bailleul. University of Missouri and University of Missouri School of Medicine. E7 577.7 Comparative Anatomy and Biomechanics of the Feeding Apparatus of Parrots (Aves: Psittaciformes) I.N. Cost, K.M. Middleton, L.M. Witmer, M.S. Echols, C.M. Holliday. University of Missouri, Ohio University and Echols Veterinary Services. E8 577.8 Functional-Morphological Diversity and Complexity of the Larynx as a Basis for Vocal Complexity in Birds: Analogies to Human Speech. D.G. Homberger. Louisiana State University. E9 577.9 Free-Body Diagram Force Analysis in 2D and 3D: A Tool to Study Comparative Vertebrate Biomechanics. M.L. Osborn, A. Rau, J. Ge, D.G. Homberger. Lousiana State University School of Veterinary Medicine and Louisiana State University. E10 577.10 A Mathematical Model of Beaver Incisor Tooth Morphology. C.E. Rinaldi, S.M. Kuhn-Hendricks, G.M. Erickson. University of Texas-Southwestern and Florida State University.

E11 577.11 Mechanical and Biological Response of Alveolar Bone with Tooth Under Traumatic Occlusion in Rats: Experimental Analysis Associated to Computer Simulation. A. Rossi, A.R. Freire, R. Okamoto, S.T. Costa, P.R. Botacin, F.B. Prado. Piracicaba Dental School—University of CampinasUNICAMP, Brazil and Araçatuba Dental School—Paulista State University-UNESP, Brazil. E12 577.12 Musculoskeletal Morphology of the Hip and Thigh of the Black-Footed Ferret (Mustela nigripes) V.L. Naples. Northern Illinois University. E13 577.13 A Major Paradigm Shift in Fish, Tetrapod and Limb Evolution: Characteristic Tetrapod Musculoskeletal Limb Phenotype Emerged More Than 400 MYA in Basal Lobe-Finned Fishes. R. Diogo, J. Molnar, B. Esteve-Altava, P. Johnson. Howard University and University of Auckland, New Zealand. E14 577.14 The Effect of Growth Rate and Biomechanical Loading on Bone Laminarity in the Emu Hindlimb. A. Kuehn, E.L. Simons, A.H. Lee, R.P. Main. Midwestern University and Purdue University. E15 577.15 Comparing Femur Cross-Sectional Morphology in Young Outbred Mice Following Daily Exposure to Muscle-, Impact-, or Combined Loading of the Hind Limb Skeleton. A.N. Smolinsky, K.M. Middleton. University of Missouri. E16 577.16 Low-Impact Climbing Exercise During Growth Enhances Skeletal Muscle Function. J. Organ, K. Biro, B. Vickery, G. Monnin, D. Waning. Indiana University School of Medicine and Pennsylvania State University. E17 577.17 Chikungunya Virus Infection Alters New Bone Formation Associated with Pre-Existing Post-Traumatic Osteoarthritis. M.A. McNulty, B.A. Goupil, A. Moses, C.N. Mores. Louisiana State University School of Veterinary Medicine and Indiana University School of Medicine. E18 577.18 Effects of Perinatal Circadian Programming on Activity and Skeletal Morphology in C57BL/6 Mice. S.J. Peacock, K. Bates, O.O. Talton, L.C. Schulz, K.M. Middleton. University of Missouri. E19 577.19 Ontogenetic Changes in the Terrestrial Locomotion of the American Alligator (Alligator mississippiensis) K. Manfredi, J. Georgi. Midwestern University. E20 577.20 Potus flavus: Linking Tail Integumentary Function and Microanatomical Structure. S.A. Ruiz Palacios, J.H. Plochocki, J.R. Rodriguez-Sosa, M.I. Hall. Midwestern University. E21 577.21 Copulatory Fit of Common Bottlenose Dolphin (Tursiops truncatus) Genitalia. D. Orbach, P. Brennan. Dalhousie University, Canada and Mount Holyoke College.

578. BIOLOGICAL ANTHROPOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Evolution/Anthropology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E22 578.1 First Detailed Anatomical Study of Bonobos Exposes Just-So Stories of Human Evolution, Anatomy, Variations, Bipedalism and Tool Use. R. Diogo. Howard University.

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SUNDAY ANATOMY E23 578.2 Craniofacial Adaptation and Upper Respiratory Function Among High-Altitude Inhabitants. L.N. Butaric, R.P. Klocke. Des Moines University. E24 578.3 Differences in Foramen Magnum Size and Shape Among Sexes in Diverse Populations. A.W. Koons, M.L. Russell, K.N. Bliss, K.R. Mangus, M.J. Zdilla. West Liberty University. E25 578.4 The Effect of Dental Senescence on Fecal Particle Size for Propithecus diadema in the Fragmented and Pristine Forests of Tsinjoarivo, Madagascar. K.S. Heffernan, K.E. Samonds, M. Irwin. Northern Illinois University. E26 578.5 The Prevalence of Supraorbital Foramina and Notches Among Different Populations, Sexes, and Sides. K.N. Bliss, A.W. Koons, M.L. Russell, K.R. Mangus, M.J. Zdilla. West Liberty University. E27 578.6 Comparison Analysis of Metopism Prevalence in Sexes and Various Populations. K.N. Bliss, M.L. Russell, A.W. Koons, K.R. Mangus, M.J. Zdilla. West Liberty University. E28 578.7 Phylogenetic Influences on Tooth Mineral Density in Primates. L.M. Zeigler, K.A. Paddock, C.M. Ficorilli, M.E. Millen, B.M. Harvey, R.T. Hogg, C.J. Vinyard, M.M. Muchlinski, V.B. DeLeon, T.D. Smith. Slippery Rock Univ. E29 578.8 Synchondroses of the Anterior Chondrocranium in Primates. S. Engel, J.L. Wu, C. Llera, M.P. Zumpano, V.B. DeLeon, T. Smith. Slippery Rock University, University of Florida and New York Chiropractic College. E30 578.9 Tooth Mineral Density in Primates: Effects of Developmental Strategies and Dietary Preference. K.A. Paddock, L.M. Zeigler, B.M. Harvey, M.E. Millen, C. Vinyard, M.M. Muchlinski, V.B. DeLeon, T.D. Smith. Slippery Rock Univ, NEOMED, University of North Texas and University of Florida. E31 578.10 Adult Female Human Bony Pelvis Obstetric Morphology Differences with Respect to Age Are Not Due to Selection. B.M. Auerbach. The University of Tennessee. E32 578.11 Femur Measurement in Photoanthropometric Analysis. Surface Projection of Inguinal Ligament, with or Without Garments, Is a Reliable Landmark? M. Cusimano. FORMED conv. Second University of Naples, Italy. E33 578.12 Phylogenetic Utility of Mammalian Postcranial Characters. R.C. McCarthy, T.A. DiVito III, J. Bains, M. Fatima. Benedictine University and Nova Southeastern University. E34 578.13 Sexual Dimorphism in Facial Fluctuating Asymmetry Among Hausa Population of Nigeria M.G. Taura, L. Adamu, B. Danborno. Bayero University Kano, Nigeria, University of Bisha, Saudi Arabia, Ahmadu Bello University and Zaria, Nigeria. E35 578.14 Sexual Anatomy Differs Between Orthograde and Pronograde Primates and Other Mammals: Implications for Human Evolution. M.I. Hall, J.H. Plochocki, J.R. RodriguezSosa, S. Ruiz. Midwestern University. E36 578.15 Osteons and Osteocytes in Belanger’s Tree Shrews (Tupaia belangeri)—A Comparative Study. Q. Wang, V. Kondru, M.J. Kesterke, J.Q. Feng. Texas A&M University College of Dentistry. E37 578.16 Cranial and Appendicular Skeletal Elements Show Correlated Responses to Selection Among Large-Bodied and Small-Bodied Tamarins. E.R. Agosto, B.M. Auerbach. University of Tennessee- Knoxville. E38 578.17 Spinal Process Shape and Vertebral Immobility in Hominoids and Hox9 Mutant Mice. A.L. Machnicki, S.M. Hrycaj, D.M. Wellik, P.L. Reno. Pennsylvania State University and University of Michigan.

E39 578.18 Musser’s Cryptids: Resolving Unknown or Disputed Species Identities in Scientific Collections. K. Tuttle. Northern Illinois University.

579. VERTEBRATE PALEONTOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Vertebrate Paleontology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E40 579.1 Biomechanics and the Evolution of the Crocodyliform Skull. K.C. Sellers, K.M. Middleton, J.L. Davis, C.M. Holliday. University of Missouri and University of Southern Indiana. E41 579.2 Restoring Dinosaur Cephalic Vascular Anatomy and Thermophysiology Using Osteological Correlates and Anastomotic Connections. W.R. Porter, L.M. Witmer. Ohio University. E42 579.3 Seriated CT-Scan of an Egg in Aepornis maximus (Madagascar) and Reconstructions. P.P. Le FlochPrigent, J. Gillot, S. Verdeille. Université de Versailles-Saint Quentin, France, Metropolitan, Librairie Scientifique Alain Brieux, France and Clinique du Val d’Or, France. E43 579.4 Changes in Pectoral Appendicular Muscle Anatomy and Function Over the Water-Land Transition in Tetrapods. J. Molnar, J. Hutchinson, R. Diogo, S. Pierce. Howard University College of Medicine, Royal Veterinary College, United Kingdom and Harvard University. E44 579.5 The Nasal Salt Gland of Extant Birds: Anatomical Structure and Its Relevance for Inferring the Behavior and Habitat Preferences of Extinct Birds. E.G. Caggiano, D. Cerio, W.R. Porter, R.C. Ridgely, L.M. Witmer. Ohio University.

580. ANATOMY EDUCATION: TECHNOLOGYASSISTED LEARNING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E45 580.1 The Use of Softchalk Modules to Prepare First Year Medical Students for Upper Limb Cadaver Dissections. T.R. Tooley, M. Ahmed, L. Helland, S. Dykowski, M. Barremkala. Oakland University William Beaumont School of Medicine. E46 580.2 Telequantum Medical Technologies Taught, Practiced, and Assessed by Medical Students in a Millennial Anatomy Lab Developing Telemedicine Skills. B. Benninger, W. Chen. Western University of Health Sciences COMP-Northwest. E47 580.3 Development of an Effective iBook to Educate Veterinary Students About the Ovariohysterectomy Procedure on Small Animals. C.C. Ng, C. Schmiedt, J. Moore, K. Mount, K. Brennan, J. Daugherty. University of Illinois at Chicago and University of Georgia.

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ANATOMY SUNDAY E48 580.4 Macanatomy Pathology Learning Tool Project. B. Cao, X. Brual, A. Kurdina, I. Bayer, B. Wainman. McMaster University, Canada. E49 580.5 Using Focus Stacking in Anatomical Imaging: Does It Make a Difference? S.C. McWatt, L.C. Jadeski. University of Guelph, Canada. E50 580.6 Use of OneNote as a Platform for Anatomical Education. A. Campbell, K. Wilson, J. Olson. A.T. Still University. E51 580.7 Assessing Emotional Stress, Active Recall and Digital Spaced-Learning Media in the Study of Thoracic Gross Anatomy by Medical Students. R. Cole, D. McHugh. Frank H. Netter MD School of Medicine and Quinnipiac University. E52 580.8 A Pilot Study Examining the Impact of Two-Dimensional Computer Images and ThreeDimensional Stereoscopic Images of the Pelvic Muscles and Neurovasculature on Short-Term and Long-Term Retention of Anatomical Information for First-Year Medical Students. E.R. Meyer, A.M. James, D. Cui. University of Mississippi Medical Center. E53 580.9 An Interactive Program Incorporating 3D Models and 2D Illustrations for Enhanced Prostate MRI Training. T. Raber, L. Lebowicz, A. Oto, C. Westin, K. Brennan, D. Hughes. University of Illinois at Chicago and University of Chicago. E54 580.10 The Development of a Globally Accessible Interactive Anatomy Web Atlas. A. Mordhorst, M. Fejtek, A. Siddiqui, C. Krebs. University of British Columbia, Canada. E55 580.11 BlueLink Resources for Dental Head and Neck Anatomy: The Effectiveness of Tailored Multimedia. G.M. Fox, K. Alsup. University of Michigan Medical School. E56 580.12 The Anatomy of Traditional and E-Learning Education: How the Spatial Ability of Learners Can Impact Learning Outcomes. S.E. Van Nuland, K.A. Rogers. The University of Western Ontario, Canada.

581. ANATOMY EDUCATION: ACTIVE LEARNING, FLIPPED CLASSROOM, TBL

E61 581.5 The Benefits of Pair-Share Concept Mapping in Anatomy and Embryology. C. Elzie, C.W. Goodmurphy. Eastern Virginia Medical School. E62 581.6 Early Implementation of a Team Based Learning Session Focusing on Study Strategies and Content Knowledge Expectations Improves Student Performance on Their First Anatomy Exam. E. Johnson. Alabama College of Osteopathic Medicine. E63 581.7 Does Team-Based Learning Have a Positive Effect on Student Learning Outcomes in a Medical Developmental Anatomy Course? H. Abisamra, B. Treadway, M. Conway. University of Mississippi Medical Center. E64 581.8 Developing a Team-Based Learning Module for Large Classes in Medical School. J. Prange-Kiel, J.G. Champine, A.J. Winkler, D.M. Twickler. University of Texas Southwestern Medical Center at Dallas. E65 581.9 A Formal Interprofessional Ultrasound Curriculum Between Medical and Physical Therapy Students in the First Year Gross Anatomy Course. C.M. Gibbs, J.A. Knight, S.E. Van Nuland, A. Bhagra, N.J. Hellyer, N.R. Langley. Mayo Clinic School of Medicine, The University of Western Ontario, Canada, Mayo Clinic and Mayo Clinic College of Medicine and Science. E66 581.10 Clinical Educators’ Views of a Paired Anatomy Teaching Assistant and Clinician Teaching Model for Ultrasound Training During Gross Anatomy. D.F. Royer, J.L. Kendall. University of Colorado School of Medicine and Denver Health System. E67 581.11 Withdrawn. E68 581.12 Think FAST: Using a Clinical Ultrasound Examination to Study Abdominal Anatomy. L.A. Hoffman. Indiana University School of Medicine. E69 581.13 Evaluation of a New Temporally and Fiscally Economical Ultrasound Training Program for First-Year Medical Students. N.L. Mason, J. Puglisi, A. Mullen, B. Kim. California Northstate University College of Medicine.

582. ANATOMY EDUCATION: TEACHING AND LEARNING STRATEGIES AND METHODS

Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E57 581.1 Flipping the Anatomy and Neuroanatomy Classrooms in the First Year of Dental School. R.E. Druzinsky, A.F. Doubleday. University of Illinois. E58 581.2 Student Attitudes Toward a Flipped Classroom Design for Circulatory System in Medical School Gross Anatomy. S. Curran, D. Royer. University of Colorado Anschutz Medical Campus and University of Colorado School of Medicine. E59 581.3 A Pilot Study Into Flipping Neuroanatomy— Student Performance and Experience Results. E. Jennings, S. Long. James Cook University, Australia. E60 581.4 Using Practical-Based Team Based Learning as a Tool for Providing an Immediate Feedback to the Students During Learning Anatomy. M.A. Eladl, A.A. Jaffar, A. Ranade. College of Medicine, University of Sharjah, United Arab Emirates, Mansoura University, Egypt and Dalhousie University, Canada.

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Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E70 582.1 The Use of Clay Models to Teach Pelvic Anatomy to First and Second Year Medical Students at OUWB School of Medicine. B. Schmidt, B.J. Thompson, A. Chang. Oakland University William Beaumont School of Medicine. E71 582.2 Physical Models Dominate: The Pirate Patch Study. L.K. Wolak, G.A. Pukas, Y. Zheng, G.R. Norman, S.D. Monteiro, B.C. Wainman. McMaster University, Canada. E72 582.3 Revolutionizing Musculoskeletal Anatomy Teaching with Microvids-Guidelines: A Pilot Study. F.A. Huber, L. Hirtler, F.M. Kainberger. Medical University of Vienna, Austria. E73 582.4 Learning with Concept Maps and Evaluation of Individually Prepared Concept Maps Versus Concept Maps Prepared in Groups. M.K. Anand. Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India.

SUNDAY ANATOMY E74 582.5 Student Generated Structure Lists: Bringing Self-Directed Learning Into the Anatomy Laboratory. S.M. Dunham. Indiana University. E75 582.6 A Homemade Model That Helps Students Visualize Inguinal Canal Embryology, Anatomy, and Pathology. C. Pittack. Bastyr University. E76 582.7 Teach & Learn in Histology: An Old Approach Revisited. J. Iskandar, I. Hajj Hussein. OUWB School of Medicine. E77 582.8 Learning the Cardiovascular System Can Be PhUn. A.J. Gonzalez, M.E. Velez. Texas A&M- Kingsville. E78 582.9 Weaving the Human Body—An Innovative Pedagogical Proposal for the Visually Impaired/The Human Body and Modern Risks—Itinerant Museum of Anatomy 2 (IMA 2): Drugs. T.S. Masuko, J.O. GonÇalves, R.V. dos Santos’ Coutinho, H.H. da’Silva-Lima, P.d. ‘da SilvaCarvalho, J. ‘Nascimento-Santos, C.A C. Baptista. UFBA—Federal University of Bahia, Brazil and University of Toledo. E79 582.10 Teaching the Brachial Plexus to Medical Students in a Humane and Useful Way. D.A. Cotanche. University of Illinois at Chicago College of Medicine. E80 582.11 Effectiveness of Computer Assisted Learning in Anatomy and Physiology. N.T. Hilvano. University of Cincinnati Clermont. E81 582.12 Case-Based Learning Using Cadaveric Pathology Specimens Enhances Learner Engagement in Reviewing Normal Anatomy. M. Moon, D. O’Donoghue, F. Miller, K. Klump, N. Halliday. OU College of Medicine and College of Medicine. E82 582.13 Using Flipped Model and Drawing Tutorials to Teach Neuroanatomy in Graduate Certificate Program in Intraoperative Neuromonitoring. R. Filipovic, P. Andalib. University of Connecticut. E83 582.14 Enhancing Anatomy Learning by Combining Body Painting, Ultrasound, Clinical Investigation and PeerTeaching. L. Filgueira, E. Eppler. University of Fribourg, Switzerland, University of Zurich, Switzerland and University of Basel, Switzerland. E84 582.15 Impact of Team-Based Virtual Microscopy on Student Learning in Histology. P. Potaliya, S.G. Dixit, S. Ghatak. All India Institute of Medical Sciences, India and All India Institute of Medical Science, India. E85 582.16 A Crossover Randomized Controlled Trial to Evaluate the Use of Animations and Interactivity in Anatomy and Physiology Education. H. Chen, M. Ng, A. Kirubarajan, K. Kuo, A.K. Ball, I. Bayer, P.B. Helli, B.C. Wainman. McMaster University, Canada. E86 582.17 Examination of Active Learning by Sketching on the Academic Performance of Students Studying Embryology. A. Hryniuk. Augusta University. E87 582.18 Withdrawn. E88 582.19 “An Unexamined Life Is Not Worth Living”: Using Digital Journals to Promote Reflection in the Classroom. A.F. Doubleday, M.D. Strotman. University of Illinois at Chicago. E89 582.20 Anato-Olympics: Can Group Based Competition Activity Among Undergraduate Students Improve Their Performance on the Real-Time Restricted-Practical Evaluation. H. Carrero, E.H. Monroig, J.A. Solivan, M.V. Duprey-Diaz. University of Puerto Rico-Rio Piedras Campus.

E90 582.21 Tutor Group Assessments (TGAs): Criteria Based Monitoring of Medical Student Performance, Participation and Behavior in Small (Tutor) Group Sessions in a Problem Based Learning Curriculum. N.S. Viscomi, L.F. DiLalla, N. Henry, R.W. Clough. Southern Illinois University School Medicine. E91 582.22 Training of Near-Peer Tutors in the Gross Anatomy Laboratory. S.D. Hunter, D. O’Donoghue, F. Miller, N. Halliday. University of Oklahoma Health Sciences Center. E92 582.23 Improved Medical Student Perception of Ultrasound Using a Paired Anatomy Teaching Assistant and Clinical Instructor Model. J. Smith, J. Kendall, D. Royer. University of Colorado School of Medicine. E93 582.24 Innovations in Musculoskeletal Anatomy Education: Clinically Based Near-Peer and Reciprocal Peer-Teaching. W. Lackey-Cornelison. Western Michigan University and Homer Stryker MD School of Medicine. E94 582.25 Using a Dissection-Based Introductory Laboratory Video to Reduce the Anxiety State of Dissectionand Prosection-Based Anatomy Students Prior to Their First Cadaver-Based Laboratory Experience. W. Albabish, G. Newton, L. Jadeski. University of Guelph, Canada. E95 582.26 Approaches to Study and Preferred Learning Environments of First Year Medical Students in an Anatomy Course. P. Reves, K. Thompson, A. Notebaert. University of Mississippi Medical Center and Millsaps College. E96 582.27 Clinical Anatomy and Imaging Lab: Vertical Integration in a Preclinical Reproductive Organ Systems Course. M. Hankin, H. Hoops, P. Mclaren, S. Hecht, D. Stadler, M. O’Reilly. Oregon Health and Science University.

583. ANATOMY EDUCATION: CURRICULUM DESIGN AND EFFECTIVENESS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E97 583.1 Essential Anatomy in Undergraduate Medical Curricula: Orthopedics and Obstetrics and Gynecology. M. Hankin, A. Aschmetat, I. Niculescu. Oregon Health and Science University, William Beaumont Hospital and Oakland University William Beaumont School of Medicine. E98 583.2 Histology Education in the Next Generation. P.A. Shaw, M. Hernandez. Icahn School of Medicine at Mount Sinai. E99 583.3 Evaluation of Objectives-Based Learning Outcomes in a Compressed Presentation of Human Structure. K.E. Klump, M. Moon, F. Miller, D.L. O’Donoghue, N. Halliday. University of Oklahoma Health Sciences Center. E100 583.4 Teaching Anatomy to Meet the CanMEDs Competencies. C. Krebs, B. Wainman. University of British Columbia, Canada and McMaster University, Canada. E101 583.5 The Ob-Gyn and Women’s Health Selective Pathway for Senior Medical Students: The Clinical Pelvic Anatomy Laboratory Course. F. Nausheen, F. Nausheen, S. Wong, G. Valenzuela, R. Suskind, A. Tenore, L. Castro. California University of Science and Medicine, School of Medicine, Arrowhead Regional Medical Center.

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ANATOMY SUNDAY E102 583.6 Evaluation of Curricular Factors That Impact Residency Specialty Choice. L. Kim, C.A. Nichols, A.C. Edmondson. Medical College of Georgia at Augusta University. E103 583.7 Integration of the Educators: Training Program to Bridge the Foundational-Clinical Science Divide in Medical Training. A.C. Zumwalt, M. Dominguez. Boston University School of Medicine. E104 583.8 Development of a Model for Evidence Based Integration of Anatomy Into a Competency Based Undergraduate Medical Education Curriculum. M.E. Norris, M.I. Johnson, K.A. Rogers, C.M. Martin. The University of Western Ontario, Canada. E105 583.9 Development of the Summer Anatomy Enrichment Program for Rising Second Year Medical Students. E.L. Giannaris. University of Massachusetts Medical School. E106 583.10 Keeping Traditions? Perceptions of Anatomy’s Relevance to Clinical Training and Practice Across Successive Cohorts of Graduating MD Students in a New Medical Program. O. Oyedele. University of British Columbia Okanagan, Canada. E107 583.11 Anatomical Knowledge Retention in Changing Curricula. A.N. Lean, J. Lee, E. Goldman, G. Butera, K. Brown, R.A. Jurjus. The George Washington University School of Medicine. E108 583.12 Creating a Master List of Neuroscience Topics for Pre-Clinical Medical Education. D. Gould, G. Patino, V. Osula. OUWB. E109 583.13 Vertical Integration of Anatomy: Achieving the Desired Outcomes? M.D. Lazarus, A. Rascoe, D. Anderson, K. Black. Monash University, Australia, Case Western Reserve University, Strong Memorial Hospital and Penn State University. E110 583.14 Integrated Histology and Pathology Education in the Renewed UBC M.D. Undergraduate Program. K. Pinder, M. Nimmo, D. Cooper, M. Allard, H. Yule, S. Maurice. University of British Columbia, Canada. E111 583.15 Creating Milestones and Exit Competencies for Medical School Education in Histology. K. Pinder, J. Ford. The University of British Columbia, Canada and Sidra Medical and Research Center, Qatar.

584. ANATOMY EDUCATION: ONLINE AND E-LEARNING MODULES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E112 584.1 Production and Qualitative Analysis on Histology Assessment Application for Online and Mobile Learning. B.E. Culleen, L.M. Lee. University of Colorado. E113 584.2 Using Assessment to Promote Deep and Active Learning in an Online Anatomy Course. K. Kolomitro, L.W. MacKenzie. Queen’s University, Canada.

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E114 584.3 Telequantum Medical Education: Developing Teleportation, Telecommunication and Tele Emotion Skills During Basic Science Curriculum to Train Medical Students Current and Future Telemedicine Healthcare. W.W. Chen, B. Benninger. Western University of Health Sciences COMP-Northwest. E115 584.4 Directions Toward an Open-Access, University of Michigan Anatomy Website Through BlueLink Anatomical Learning Tools. K. Alsup, G.M. Fox. University of Michigan. E116 584.5 Small Group Self-Directed Learning Exercises Using a Cloud-Based Interactive Website Facilitates Application of Histology to Pathological Diagnosis. H. Ressetar, B. Palmer. West Virginia University School of Medicine. E117 584.6 Impact of Integrating Interactive Neuroanatomy e-Learning Resources on Novice Student Learning. L. Allen, R. Eagleson, S. deRibaupierre. Western University, Canada. E118 584.7 Using Interactive Online Learning Modules in Histology to Improve Long-Term Retention and Efficiency of Learning. R.L. Russell, P. Luna, D.E. Chico. Texas A&M University. E119 584.8 The Long-Term Effectiveness of Online Learning Modules for the Study of Anatomy. B. Aziz, V. Lee. TTUHSC.

585. CARDIOVASCULAR BIOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Biology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E120 585.1 Visualizing Human Embryonic Development of the Heart’s Outflow Tract. C.A. Sidorowych, L. Lebowicz, J. Daugherty, K. Brennan, D. Cotanche, C. Ross, S. Bond. University of Illinois at Chicago and University of Chicago. E121 585.2 Quantification of Structural Heterogeneities Within the Human Left Atrium Throughout the Lifespan. J.A. Sakowski, M.I. Hurley, M.P. Olivieri, M.E. Gervasi, M.F. Swartz. D’Youville College and University of Rochester Medical Center. E122 585.3 Quantification of Potassium Ion Channel Transcripts Within the Human Left Atrium Throughout the Lifespan. J.A. Coello, M.I. Hurley, M.P. Olivieri, M.E. Gervasi, M.F. Swartz. D’Youville College and University of Rochester Medical Center. E123 585.4 A Comparison of Atherosclerotic Lesion Severity in the Carotid Bulb Versus Coronary Arteries. A.B. Lawson, W.P. Newman, G. Rae. Louisiana State University Health Sciences Center (LSUHSC). E124 585.5 Morphology and Morphometric Analysis of Right and Left Coronary Arteries in Human Cadaveric Hearts. S.V. Sarangapani, S. Subramaniam. SRM Medical College and Hosppital and Research Centre, India. E125 585.6 Rare Variant of the Great Cardiac Vein. A Case Report. E. Dăescu, A. Enache, D. Sztika, D.E. Zahoi. University of Medicine and Pharmacy Victor Babe?, Romania.

SUNDAY ANATOMY E126 585.7 Double Superior Vena Cava: A Cadaveric Case Report. M.P. McGuinness. Philadelphia College of Osteopathic Medicine. E127 585.8 Visualization of Differential Myelinated Cardiac Plexus Fiber Innervation in Heart Failure Using the Sihler’s Stain Technique. A. Hilton, A. Jorgensen, B. Gardiner, S. Robison, H. Lambert, D. Morton, J. Wisco. Brigham Young University, Wake Forest University, West Virginia University and University of Utah. E128 585.9 CABG in a Cadaver: A Case Report and Review of the Literature. Gardner. BGSU Firelands. E129 585.10 Morphological Analysis of Bronchial Arteries and Variants with Computed Tomography Angiography, and Its Relevance in the Treatment of Massive Hemoptysis. R.E. Elizondo Omaña, C.N. Esparza Hernandez, J.M. Ramirez Gonzalez, R.A. Cuellar Lozano, C.S. Gonzalez Arocha, B. Martínez Gonzalez, R. Pinales Razo, G. Elizondo Riojas, S. Guzmán López. Universidad Autónoma de Nuevo León, Mexico. E130 585.11 Geometric Morphometric Comparison of Retinal Veins Between Healthy Individuals and Individuals Diagnosed with Glaucoma and Diabetic Retinopathy. A.W. Koons, M.J. Zdilla. West Liberty University. E131 585.12 Remodelling of the Atrioventricular Canal Myocardium Determines Atrioventricular Conduction Patterns. O. Nanka, R. Vicente-Steijn, N.A. Blom, M.R. Jongbloed, D. Sedmera. Charles University, First Faculty of Medicine, Czech Republic, Leiden University Medical Center, Netherlands and Czech Academy of Sciences, Czech Republic. E132 585.13 The Nkx2.5 Mutation Affects Impulse Conduction of Developing Heart. V. Olejnickova, P. Hamor, A. Kvasilova, D. Sedmera. First Faculty of Medicine, Charles University, Czech Republic, Academy of Sciences of the Czech Republic, Czech Republic and Academy of Sciences of the Czech Republic, Czech Republic. E133 585.14 Development of the Cardiac Conduction System in the Selected Groups of Reptiles as Determined by HNK-1 Expression. A. Kvasilova, M. Gregorovicova, D. Sedmera. First Faculty of Medicine, Czech Republic and The Czech Academy of Sciences, Czech Republic. E134 585.15 Anatomy of the Aortic Arctic Branches and Visceral Collars of the Abdominal Aorta of the Night Monkey (Aotus sp) C.F. Silva, E.F. Sena, S.S. Júnior, C.S. Bortolini, M.J. Bortolini, Y.K. Carvalho, R.P. Silva. Federal University of Acre, Brazil. E135 585.16 The Effect of a Soft-Embalming Solution on the Histological Structure of Porcine Cerebral Vasculature. J. Rockarts, T. Li, S. Pang, L. MacKenzie. Queens University, Canada.

586. CARDIOVASCULAR BIOLOGY: DEVELOPMENT, GROWTH AND DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Biology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E136 586.1 Ciona as a Simple Chordate Model for Heart Development and Regeneration. H. Evans Anderson. Winthrop University. E137 586.2 Cautery Injury Response in the Zebrafish Heart. N. Hockaden, N. Pillai, P.J. Lafontant. DePauw University. E138 586.3 Functional Characterization of stap2b in Zebrafish Vascular Development. Y. Wang, C. Wu. National Sun Yat-sen University, Taiwan, Department of Biological Sciences, National Sun Yat-sen University and Taiwan, Taiwan. E139 586.4 Coral-Derived Natural Marine Compound GB9 Inhibits Vascular Development in Zebrafish. Y. Song, C. Wu. National Sun Yat-sen University, Taiwan. E140 586.5 Metastatic Cancer Cells and Endothelial Cells Show Increased Expression of Transforming Growth Factor (TGF) Beta Receptors Related to Angiogenesis. J. Hawker, I. Duffy. South Florida State College and Saint Leo University. E141 586.6 Loss of lnx1 Impairs Vascular Development Mediated by Reduction of VEGF/ERK and BMP Signalings. Z. Chen, C. Wu. National Sun Yat-sen University, Taiwan. E142 586.7 The Morphological Mapping of Mesenteric Lymphatic Network. I.T. Nizamutdinova, C.A. Davis, M.R. Moreno, D.C. Zawieja. Texas A&M Health Science Center and Texas A&M University. E143 586.8 Kv1.1 Potassium Channel Deficiency Prolongs Ventricular Action Potentials and Decreases Tachycardia Susceptibility. K. Trosclair, M. Si, M. Watts, P. Dominic, K. Hamilton, E. Glasscock. Louisiana State University Health Science Center. E144 586.9 Chronic Heart Rate Reduction by Ivabradine Does Not Modify the Elastic Fiber Content in Post-Myocardial Infarction Scar of Middle-Aged Rats. E.I. Dedkov, R.J. Tomanek. Cooper Medical School of Rowan University and University of Iowa Carver College of Medicine. E145 586.10 Evaluation of Toxicological Properties of Toad Parotid Gland Extract on Heart of Adult Male Wistar Rat. C. Ihentuge, G. Ndukwe, F. Akpuaka, H. Okechukwu. Abia State University, Nigeria, Howard University, and IMO State University, Nigeria. E146 586.11 Gender Differences in Adiposity and Its Relationship to Cardiometabolic Profiles and Proinflammatory Adipokines in Spinal Cord Injury. G.J. Farkas, A.S. Gorgey, D. Dolbow, A.S. Berg, D.R. Gater. Penn State College of Medicine, Hunter Holmes McGuire VA Medical Center and University of Southern Mississippi. E147 586.12 Contribution of Macrophages to Myxomatous Valve Disease. A. Hulin, S. Potter, A. Kim, T. DeFalco, K. Yutzey. CCHMC. E148 586.13 Ventricular Growth and Coronary Vessel Development in the Giant Danio (Devario aequipinnatus) Heart. O. Shifatu, S. Glasshagel, P. Patel, H. Nelson, W. Tomamichel, C. Higginbotham, P.J. Lafontant. DePauw University.

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Biochemistry and Molecular Biology 587. UNDERGRADUATE EDUCATION (ASBMB) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B1 587.1 A Multiweek Tyrosinase Inhibitor Synthesis and Analysis Project: A Capstone Experiment for the Undergraduate Biochemistry Laboratory Course. P.S. Mertz, C.N. Streu, R.D. Reif, K.Y. Neiles, A.J. Schech. St. Mary’s College of Maryland, Albion College and University of Mary Washington. B2 587.2 Research and Writing to Promote Critical Thinking in Undergraduate Education. R.P. Rogers. Wentworth Institute of Technology. B3 587.3 Development of Learning Progressions Through the Chemistry Curriculum to Biochemistry. A.J. Wolfson, A.M. Mercer, E.G. Offerdahl, J.E. Lewis. Wellesley College, University of South Florida and Washington State University. B4 587.4 Improving STEM Student Retention via Early Research Engagement: A Pilot. P.G. Bouyer, M. Watters. Valparaiso University. B5 587.5 Teaching Chemical Biology at a Primarily Undergraduate Institution. A.M. Danowitz. Mercyhurst University. B6 587.6 Using an Alternate Reality Learning Experience (ARLE) to Teach Molecular Biology Techniques and Concepts in a Genetics Laboratory. C.L. Clauson-Kozina, J.D. Borden, S. Rheinschmidt, G. Kunzweiler. Saint Leo University. B7 587.7 Understanding the Phenomenological and Ontological Identity of the Black Seminole in Southwest Texas as a Means for Historical Preservation and Formation of a Community Narrative. P. Torres, M. Trevino, B. Villasenor, K. Pena, G. Villareal, D. Rincon, I. Vasquez, J. Barrera, J. Verastegui, N. Carrillo, C. Williams, R. Escamilla, R. Pena, C. De La Cerda, J. Porras, E. Ramirez, J. Riojas, V. Williams, D. Johnson; Jr. Southwest Texas Junior College. B8 587.8 what the Biochemistry Education Research Literature Can Tell University-Level Biochemistry Instructors. F.K. Lang, G.M. Bodner. Purdue University. B9 587.9 Integration of Literature-Based Activities to Enhance the Learning of Content, Scientific Process, and Quantitative Analysis in Biochemistry Courses. H. Masuda. Indiana University Kokomo. B10 587.10 Teaching Cell Signaling Through Research: The Freshman Research Initiative at the University of Texas at Austin. G. Clark, S. Rodenbusch, S. Roux. University of Texas at Austin. B11 587.11 Execution and Assessment of a Mindset Intervention in an Introductory Biochemistry Class. D.J. Hall. Lawrence University. B12 587.12 Introduction of Enzymatic Polymer Degradation to Enhance the Undergraduate Polymer Chemistry Curriculum. A.E. Neely, N.Y. Davis, M.H. Weiland. Armstrong State University.

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B13 587.13 Northwest Biosciences Consortium RCN-UBE: Organization and Development of a Faculty Network Leadership Team. A. Kruchten, E. Baumgartner, A. Beadles-Bohling, J. Brown, J. Duncan, L. Kayes, S. Kiser, S. Seidel, W. Shriner, S. Stavrianeas, C. Tillberg. The College of Saint Scholastica, Western Oregon University, University of Portland, Linfield College, Willamette University, Oregon State University, Lane Community College, Pacific Lutheran University and Mount Hood Community College. B14 587.14 Investigating Variations in Instructor-Generated Feedback as a Mediating Factor for Student Learning. E. Offerdahl, J. Boyer, M. McConnell, J. Momsen, R. Salter, K. Williams, L. Wiltbank. Washington State University and North Dakota State University. B15 587.15 Phylogenetic Analysis of RuBIsCO: An Active Learning Strategy for Teaching Plant Evolution. M. Van Stry. Lane College. B530 631.2 Stressing Interdisciplinarity to Mold the Undergraduate Experience. C.M. Keller, B.E. Bridges, J.N. Roney, D.R. Dries. Juniata College.

588. LEARNING TOOLS IN MOLECULAR BIOLOGY AND BIOCHEMISTRY UNDERGRADUATE EDUCATION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B16 588.1 A Process for Defining and Validating Learning Competencies for Course-Based Undergraduate Research Experiences in a Biochemistry Laboratory Course. S.M. Irby, N.J. Pelaez, T.R. Anderson. Purdue University. B17 588.2 A Model for a Scientific Literature and Data Analysis Driven Undergraduate Course. K.K. Resendes. Westminster College. B18 588.3 Improving Student Understanding of PreRequisite Knowledge and Long Term Understanding of Biochemical Concepts. A.T. Taylor, W.R. Novak. Wabash College. B19 588.4 Transition to a Course-Based Undergraduate Research Experience (CURE) P.A. Craig, J.L. Mills, R. Roberts, M. Pikaart, C. Daubner, S. Irby, T. Anderson. Rochester Institute of Technology, Ursinus College, Hope College, St. Mary’s University and Purdue University. B20 588.5 How Four Research Scientists Integrate Methods, Mechanisms, Context, Analogies, and Theory to Communicate Explanations About Protein Folding and Dynamics. K.A. Jeffery, N. Pelaez, T.R. Anderson. Purdue University. B21 588.6 Computational Studies of the Nudix Hydrolase Superfamily and Nitrophenyl Phosphatase Subfamily of the Had Superfamily. K. O’Donovan, J. Nulsen, P. Craig, S. O’Handley. Rochester Institute of Technology.

SUNDAY BIOCHEMISTRY B22 588.7 Variation in the Effectiveness of Clicker Use Based on Cohort Composition in a Small Upper Division Cell and Molecular Biology Course. K.K. Resendes. Westminster College. B23 588.8 Experiences of Undergraduate Students Identifying Proteins of Unknown Function as Part of a Teaching Laboratory in a Biochemistry Course. S. Daubner, J. Beckman, J. Beltran Gastelum, S. Mallet, E. Vogt. St. Mary’s University. B24 588.9 A Framework for Assessing Molecular Visualization Skills and Competencies. D.R. Dries, P.A. Craig, D. Dean, H.V. Jakubowski, W.R. Novak, A.I. Roca, C.R. Terrell, M.A. Franzen. Juniata College, Rochester Institute of Technology, University of Saint Joseph, College of St. Benedict/St. John’s University, Wabash College, ProfileGrid. org, University of Minnesota, Rochester and Milwaukee School of Engineering. B25 588.10 Assigning and Testing Function from Structure of Uncharacterized Proteins. M. Pikaart, S. Bettag, M. Cunningham, C. Da Silva, C. Gager, M. Glover, K. Jacobs, L. Kennington, J. Knol, N. Ladd, K. Mader, M.M. Magan, Y. Mao, E. Marinelli, L. Miller, R. Nickels, S. Ratliff, A. Rhodes, C. Schaar, M. Turner. Hope College. B26 588.11 Glutamic Acid 446 and Arginine 447 in Heat Shock Protein 70 (hsp70) Are Critical for Regulating Superoxide Dismutase-2 (SOD2) Function. A.J. Afolayan, R.J. Teng, G.G. Konduri. Medical College of Wisconsin. B27 588.12 Modeling Interdisciplinary Collaborations Through a Course-Based Undergraduate Research Experience (CURE) R. Roberts, J. Koeppe, S. Price, B. Allwein, T. Anderson, S. Daubner, S. Irby, J. Mills, M. Pikaart, P. Craig. Ursinus College, SUNY College at Oswego, Purdue University, St Mary’s University San Antonio, Rochester Institute of Technology and Hope College. B28 588.13 Assessing Learning Gains Through ePortfolios in an Undergraduate Biochemistry Lab. J.L. Mills, A. DiCola, R. Roberts, M. Pikaart, C. Daubner, S. Irby, T. Anderson, H.J. Bernstein, P.A. Craig. RIT, Ursinus College, Hope College, St. Mary’s University and Purdue University.

589. EXPANDING UNDERGRADUATE RESEARCH OPPORTUNITIES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B29 589.1 Approaching Undergraduate Research with Students Who Are Deaf and Hard of Hearing. A.U. Gehret, J.W. Trussell, L.V. Michel. National Technical Institute for the Deaf/Rochester Institute of Technology and Rochester Institute of Technology. B30 589.2 Examining the Research Experiences of Undergraduate Biochemistry Students: A Case Study Approach. S.L. Johnson, G.M. Bodner. Purdue University. B31 589.3 Rheostat or Toggle: Examining the Role of Non-Conserved Mutations to LURE Students Into Research. A.K. Ayella, B.R. Moriah. McPherson College and Wichita State University.

B32 589.4 Successes and Teachable Moments During a Partnership to Create a Research-Like Experience in a 2 Year College Organic Chemistry II Laboratory. N. Jaco, C. Lutz, J. Grant. University of Wisconsin-Stout and Anoka-Ramsey Community College. B33 589.5 Integrating Human Cell Culture Into Undergraduate Research Projects. C.E. Taylor. Mercyhurst University. B34 589.6 CRISPR in the Undergraduate Classroom: A CURE. H.J. Evans Anderson. Winthrop University. B35 589.7 The Council on Undergraduate Research (CUR): What’s in It for Post-Docs and New Faculty? Advancing Your Research Career with/Through the Council on Undergraduate Research. M. Wolyniak, L. Wimmers. Hampden-Sydney College and Towson University. B36 589.8 Year-Long Research Experiences in Drug Discovery May Lead to Positive Outcomes for Transfer Students. J. Beckham, L. Strong. The University of Texas at Austin.

590. EXPERIMENTAL BIOLOGY AND MEDICINE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B37 590.1 Live Cell Microscopy of Intestinal Organoid Oxygenation. R.I. Dmitriev, I.A. Okkelman, T. Foley, D.B. Papkovsky. University College Cork, Ireland. B38 590.2 Quantitative Multi-Parametric Microscopy Analysis of Live 3D Cell Models. R.I. Dmitriev, J. Jenkins, I.A. Okkelman, N. O’Donnell. University College Cork, Ireland. B39 590.3 Full-Thickness Engineered Skin Tissue with 3D Biomimetic Micro-Topography. J. Yu, E. Korkmaz, P. LeDuc, B. Ozdoganlar. Carnegie Mellon University. B40 590.4 An Integrated Biomimetic Adipose Tissue Microchip. Y. Chen, L. Ramalingam, J. Wu, N. MoustaidMoussa, W. Li. Wuhan Institute of Technology, People’s Republic of China, and Texas Tech University. B41 590.5 Dried Plums Modify the Colon Luminal Metabolome in a Rat Model of Colon Carcinogenesis. D.V. Seidel, S.S. Taddeo, M.A. Azcarate-Peril, R.J. Carroll, N.D. Turner. Texas A&M University and University of North Carolina School of Medicine. B42 590.6 Bisphenol-A and 17-β Estradiol Alter Colon Microbial Metabolites and Exacerbate Dextran Sodium SulfateInduced Colitis in Mice. J.A. DeLuca, R. Menon, R. Riordan, K.F. Allred, A. Jayaraman, C.D. Allred. Texas A&M University.

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591. GENOME DYNAMICS: DNA REPLICATION, REPAIR AND RECOMBINATION Poster

Poster

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:00 pm–2:30 pm

Presentation time: 12:00 pm–2:30 pm

Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm

Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm

B43 591.1 DDI1- and DDI2-Dependent Removal of Replication Termination Factor Domain Containing 1 (RTFDC1) from Replication Forks Is Necessary for Proper Response to Replication Stress. M.C. Kottemann, B. Conti, F.P. Lach, A. Smogorzewska. The Rockefeller University. B44 591.2 Investigating the Regulation of recA in the Emerging Pathogen Acinetobacter baumannii C. Ching, K. Gozzi, B. Heinemann, V.G. Godoy. Northeastern University. B45 591.3 Escherichia coli DinB and ReplicationTranscription Collisions. T. Tashjian, J.A. Halliday, C. Herman, V. Godoy. Northeastern University and Baylor College of Medicine. B46 591.4 Genetic and Environmental Factors That Regulate Tandem Repeat Variation in Coding Regions. S.M. Fuchs. Tufts University and Allen Discovery Center at Tufts. B47 591.5 The Effects of Replication Fork Restart on CAG Repeat Instability in S. pombe M. Gold, K. Freon, A. Su, S. Lambert, C. Freudenreich. Tufts University and Curie Institute, France. B48 591.6 Potent DNA Strand Annealing Mediated by the T7 Single-Stranded DNA Binding Protein gp2.5 A.J. Hernandez, C.C. Richardson. Harvard Medical School. B49 591.7 The Replication Factor A2 N-Terminus Is Required for Proper Progression Through Meiotic Divisions. A. Adsero, T. Wilson, S. Haring. North Dakota State University. B50 591.8 Structure and Mechanism of a Viral Genome Packaging Motor. B. Kelch. University of Massachusetts Medical School. B51 591.9 Mutagenesis of HEK293 Cells Reveals Phenotypic and Genotypic Variants Involved in Hsp90Mediated Glucocorticoid Signaling. T.M. Forst, S.M. Ryan, N. Pelle, P.J M. Murphy. Seattle University. B52 591.10 Genetic Variations at 15 Forensically Relevant Microsatellite Loci (STRs) in the Three Major Ethno-Linguistic Population Groups in Nigeria. B.U. Agbo, O.A T. Ebuehi, A.A. Osuntoki. University of Lagos, Nigeria.

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B53 592.1 Role of the Excluded Strand in DNA Unwinding by Hexameric Helicases. M. Trakselis. Baylor University. B54 592.2 Y-Family DNA Polymerase Human Pol Kappa Is More Tolerant of Changes to Its Active Site Loop Than DinB. N.M. Antczak, M. Packer, J. Walsh, P. Ippoliti, P.J. Beuning. Northeastern University. B55 592.3 Residues of Escherichia coli Thioredoxin Critical for Interaction with Phage T7 DNA Polymerase to Increase Processivity. S. Lee, N. Tran, C.C. Richardson. Harvard Medical School. B56 592.4 Dynamics of the E. coli Beta Clamp and Its Influence on DNA Loading. B. Koleva, J. Baez, J. Conway, A. Wu, P. Beuning. Northeastern University and Colgate University. B57 592.5 Understanding Conformational Changes During Translesion Synthesis: In Silico Studies of DinB. E. Perez, B. Sampoli Benitez. Marymount Manhattan College. B58 592.6 Role of Pol κ and DinB Distal Residues on Extension Step of TLS. H.R. Stern, C.L. Mills, M.J. Ondrechen, P.J. Beuning. Northeastern University. B59 592.7 The Epsilon Subunit of DNA Polymerase III in the Bacterial Response to Quinolones. Z. Whatley, N. Sy, S. DiDomenico, A. Finck. Gettysburg College. B60 592.8 Investigating the Mechanism of Trans-Lesion Synthesis by Human DNA Polymerase Kappa. T.B. Allen, Z. Younger, B. Sampoli Benitez. Marymount Manhattan College. B61 592.9 Role of Exo1 Nuclease in Telomere DNA Degradation in yku70/yku80 Mutants of S. cerevisiae J.A. Ream, L.K. Lewis. Texas State University. B62 592.10 Inflammation, Global DNA Methylation and Telomeres in Healthy Adolescents. Y. Dong, Y. Huang, B. Gutin, Y. Dong, H. Zhu. Medical College of Georgia.

SUNDAY BIOCHEMISTRY

593. CHROMATIN STRUCTURE AND GENE EXPRESSION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B63 593.1 Interactions Between Variant Histone H2A.Z and Linker Histone H1 in Budding Yeast. J. Riggs, J. Huang, L. Winston, M. Sica, S. Holmes. Wesleyan University. B64 593.2 Epigenetics and Gene Expression—Pathways, Pathway Suites and Networks at RGD’s Pathway Portal. V. Petri, G. Hayman, J.R. Smith, M. Tutaj, J. Thota, J. De Pons, M.R. Dwinell, M. Shimoyama. Medical College of Wisconsin. B65 593.3 Decipher and Target Cancer Cell Dependency on Epigenetic Mutations. G. Wang. University of North Carolina at Chapel Hill. B66 593.4 Epigenetic Manipulation of Inactive X Chromosome for Rett Syndrome Therapeutics. S. Bhatnagar. University of Virginia School of Medicine. B67 593.5 L3MBTL2 Is Required for Spermatogenesis and the Maintenance of Male Fertility. C. Meng. The Chinese University of Hong Kong, People’s Republic of China. B68 593.6 Role of Chromatin Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination Mediated Gene Silencing. H. Wang, Z. Zhang, A.E. Jones, M.B. Renfrow, C. Liu, W. An, J. Luo, W. Wu, Y. Kang, Y. Tong. University of Alabama at Birmingham, Nanyang Technological University, Singapore, University of Southern California, Chinese Academy of Sciences, People’s Republic of China, and University of Toronto, Canada. B69 593.7 Interaction of Protein Occupancy, Chromosome Structure, and Gene Regulation in E. coli G.M. Kroner, S. Scholz, T.J. Goss, X. Lin, P.L. Freddolino. University of Michigan. B70 593.8 The Role of CCCTC Binding Factor (CTCF) in Epithelial to Mesenchymal Transition (EMT) A. Bhattacharya, J. Hur, A. Dhasarathy. UND School of Medicine and Health Sciences. B71 593.9 Toward the Molecular Identification of Afr2, a Gene Implicated in Liver Cancer. Z. Grimes, R. SeipeltThiemann, M. Paterson, B. Spear. Middle Tennessee State University and University of Kentucky. B72 593.10 Chromatin Accessibility of the Dosage Compensated Drosophila Male X-Chromosome Is Established by a Context-Specific Role for the CLAMP Zinc Finger Protein. E. Larschan, J. Urban, G. Kuzu. Brown University. B73 593.11 Argonaute2 Cooperates with Laminb to Repress Transcription at Lamin-Associated Domains in Drosophila melanogaster E. Nazer, M. Chinen, R. Dale, E. Lei. National Institute of Diabetes and Digestive and Kidney Diseases and National Institutes of Health.

B74 593.12 Role of the ELL Complex in Transcriptional Regulation in S. pombe S. Gopalan, D. Gibbon, C. Seidel, Y. Zhang, L. Florens, M. Washburn, J. Conaway, R. Conaway. Stowers Institute and University of Kansas Medical Center. B75 593.13 Characterization of the SUN Domain Protein Mps3 Function in Gene Expression. L. Antoniacci, R. Lukasak. Marywood University and Marywood Univeristy. B76 593.14 INO80 Chromatin Remodeling Connects Metabolic Gene Expression to Cell Division. A.J. Morrison, G. Gowans, A. Schep, D. King, W. Greenleaf. Stanford University. B77 593.15 An Epigenetic Switch Regulates de Novo DNA Methylation at Pluripotency Gene Enhancers. H. Gowher, C.J. Petell. Purdue University. B78 593.16 Biochemical Insights Into the Mechanism of Oncohistones. P.W. Lewis. University of Wisconsin-Madison. B79 593.17 Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation. S.R. Bhaumik, R. Sen, J. Ferdoush, A. Kaja. Southern Illinois University School of Medicine.

594. CHROMATIN STRUCTURE, REMODELING AND ASSEMBLY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B80 594.1 Retention of CENP-A Nucleosomes During DNA Replication. E. Zasadzinska, J. Huang, A.O. Bailey, N.S. Lee, K.A. Wong, M.R. Jakubaszek, L. Guo, B.E. Black, D.R. Foltz. Northwestern University, University of Virginia and University of Pennsylvania. B81 594.2 Determination of Altered Bromodomain Function of Cancer-Associated Missense Mutations in Polybromo-1 C. Goetz, E. Dykhuizen, B. Smith. Medical College of Wisconsin and Purdue University. B82 594.3 Architecture of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J.K. Low, A.P. Silva, M. Sharifitabar, M. Torrado, J. Schmidberger, S.R. Webb, H. Saathoff, B.L. Parker, B. Paudel, A. van Oijen, M.J. Landsberg, N.E. Shepherd, J.P. Mackay. The University of Sydney, Australia, The University of Wollongong, Australia and The University of Queensland, Australia. B83 594.4 Roles of PARP-1-Dependent Poly(ADPRibosyl)ation in Regulation of the Catalytic Activity of Human ALC1 Chromatin Remodeling Enzyme. S. Ooi. Stowers Institute for Medical Research. B84 594.5 Complementary Roles of Pseudomonas aeruginosa Condensins in Global Chromosome Organization. B.K. Bhowmik, V.V. Rybenkov. University of Oklahoma. B85 594.6 Sequence Analysis of Mutant Chick Embryo DNA. J. Vo, J. Byk, S.R. Smith, M.A. Benore. University of Michigan Dearborn.

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595. EPIGENETIC MODIFICATIONS OF DNA AND RNA Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B97 595.1 Withdrawn. B98 595.2 Epigenetic Regulation of Alternative Developmental Trajectories. A.L. Romney, J.E. Podrabsky. Portland State University. B99 595.3 A Shared Structural Recognition Element in mRNA Substrates of the tRNA Modifying Enzyme Pseudouridine Synthase 1 T.M. Carlile, T.A. Bell, M.F. RojasDuran, B. Zinshteyn, H. Shin, C. Mason, W.V. Gilbert. MIT. B100 595.4 Epigenetic Regulation Through UHRF Proteins. S.B. Rothbart, R.M. Vaughan, E.M. Cornett, B.M. Dickson. Van Andel Research Institute. B101 595.5 Profiling of DNA Methylation Patterns in Response to Inorganic Arsenic Exposure and Reversal of Exposure. M.L. Eckstein, M. Rea, R. Eleazer, Y. FondufeMittendorf. University of Kentucky. B102 595.6 Spatio-Temporal Dynamics of Sphingosine1-Phosphate Receptor 1 Activity in Endothelial Cells During Lung Injury and Resolution. M. Akhter, D. Mehta. Department of Pharmacology, College of Medicine and University of Illinois at Chicago. B103 595.7 DNA Cytosine Methyltransferase Promotes Stationary Phase Fitness in Escherichia coli O. Kambhampati, L. Finnerty-Haggerty, R. Huss, R. Knapp, K. Militello. SUNY Geneseo. B104 595.8 Ciglitazone Prevent Inflammation in Skeletal Muscle Induced by Hyperhomocysteinemia. A. Majumder, J. Behera, S.C. Tyagi. University of Louisville. B105 595.9 Bisulfite DNA Sequencing Analyses to Detect Methylation Patterns in the P73 Gene Promoter in Prostate Cancer Cell Lines. N. Braganca, L.M. Carastro, J.J. Schabort, J.Y. Park. The University of Tampa and H. Lee Moffitt Cancer Center & Research Institute. B106 595.10 YTHDC2 Regulates Spermatogenesis Through Promoting the Translation of N6-MethyladenosineModified RNA. P.J. Hsu, Y. Zhu, H. Ma, Y. Cui, X. Shi, G. Luo, Z. Lu, H. Shi, Q. Dai, M. Clark, B. Shen, C. He. The University of Chicago, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, People’s Republic of China. B107 595.11 Free Hemoglobin Change Gene Expression Involving in Cell-Cell Signaling Through Different DNA Methylation in THP-1-Derived Macrophages. M. Cha, M. Lee. Korea Institute of Oriental Medicine, Republic of Korea.

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B108 595.12 Methylation Status of the Gene Encoding Akt2 in Cinnamon Extract Treated MCF-7 Cells. M. Hill, R. Bulko, A. Aulthouse, D. Kinder, A. Stockert. Ohio Northern University. B109 595.13 MCF-7 Morphological Changes Upon Treatment with Aqueous Cinnamon Extract. R. Bulko, R. Aljahani, A. Aulthouse, D. Kinder, A. Stockert. Ohio Northern University. B110 595.14 Combinatorial Effects of PK11195 and 5-Azacytidine as an Epigenetic Modulator for MPC1. D. Duran, R.W. O’Donnell. SUNY Geneseo. B111 595.15 Upregulating Human Leukocyte Antigen Expression in Multiple Cancer Cells Through Epigenetic Modulators. N.T. Terrigino, D.J. Nicholas, R.E. Powers, S. Dutta, R.W. O’Donnell. SUNY Geneseo. B112 595.16 DNMIi Decitabine Induces a Type I Interferon Response in Leukemia Cell Lines. D.J. Nicholas, P. Srivastava, A. AlShangity, M.J. Nemeth. SUNY Geneseo and Roswell Park Cancer Institute. B113 595.17 Deciphering the Dynamics of UHRF1Dependent DNA Methylation. R.L. Tiedemann, P.A. Jones, S.B. Rothbart. Van Andel Research Institute. B114 595.18 Investigating the Heritability of a Learned Pathogen Avoidance Behavior in Caenorhabditis elegans L.E. Meissner, G.A. Manilla, T.G. Brown, E.M. Youngman. Villanova University.

596. RNA: PROCESSING, TRANSPORT, AND REGULATORY MECHANISMS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B115 596.1 Nuclear Export Factor 3 Regulates Localization of SnoRNAs. M. Li, J. Lee, A. Sletten, K. Pyles, J. Schaffer. Washington University in St. Louis School of Medicine. B116 596.2 Nuclear Phosphoinositide Signalling Coupled Variant Poly(A) Polymerase Star-PAP Regulates Metastatic Invasion. S. Ap, R.S. Laishram. Rajiv Gandhi Centre for Biotechnology, India. B117 596.3 Withdrawn B118 596.4 The Role of mRNA Degradation in Dynamic Nitrogen Environments in Saccharomyces cerevisiae C.S. Rodriguez-Tirado, D. Gresham, F. Abdul-Rahman. University of Puerto Rico, Puerto Rico and New York University.

SUNDAY BIOCHEMISTRY B119 596.5 Potential Therapeutic Targets and Biomarkers for Seizure: Genome-Wide DE miRNA Expression Profiling of Rat Brain Following Exposure to Soman. X. Feng, A. Gautam, R. Kumar, G. Dimitrov, B. Sowe, F. Rossetti, J.L. Meyerhoff, L.A. Lumley, R. Hammamieh, M. Jett. Geneva/USACEHR, USACEHR, Walter Reed Army Institute of Research and US Army Medical Research Institute of Chemical Defense. B120 596.6 Export of Discarded, Splicing Intermediates Provides Insight Into mRNA Export. Y. Zeng, J. Staley. The University of Chicago. B121 596.7 Engineering of an Immunogenic PreTrans-Splicing RNA (iPTR) to Block Growth and Express a Glioblastoma Specific Epitope. S.C. Falotico, N. Sivetz, P. Nekrasov, M.J. Hicks. Monmouth University. B122 596.8 Unraveling the Role of Helicases in Nonfunctional rRNA Decay. V. Yu, F. LaRiviere. Washington and Lee University. B123 596.9 A Genetic Interaction Between DED1 and HAT1 in Saccharomyces cerevisiae Suggests a Role for Hat1p in Mrna Storage. A. Hilliker, A. Kindsfather, A. Winters, N. Rothbard, S. Robins, L. Fronek. University of Richmond. B124 596.10 Post-Transcriptional Modulation of aENaC mRNA Stability in Alveolar Epithelial Cells: Involvement of Conserved Domains on Its 3′ Untranslated Region. F. Gagnon, F. Migneault, Y. Berthiaume, A. Dagenais. Institut de Recherches Cliniques de Montreal, Canada. B125 596.11 Differential Alternative Splicing in Clinical Strains of Cryptococcus neoformans M.C. Merryman, E. McClelland, R. Seipelt-Thiemann. Middle Tennessee State University. B126 596.12 Dissecting the Mechanism of H3K36 Methylation in Regulating Pre-mRNA Splicing. C. Leung, S. Douglass, T. Johnson. UCLA. B127 596.13 The Role of the Essential Splicing Factor Prp2 in Ribosome Biogenesis. S. Edwards, A. Hossain, T. Johnson. University of California at Los Angeles.

597. RNA POLYMERASES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B128 597.1 P-TEFb Regulates Oocyte Maturation and Embryonic Genome Activation by Pol II CTD Phosphorylation and Ribosomal RNA Processing in Mammals. D.I. Jin, R.K. Oqani, T. Lin, J.E. Lee, S.Y. Kim. Chungnam National University, Republic of Korea.

B129 597.2 Early Elongation Control of RNA Polymerase II Transcription by TFIIS. S. Peck, M. Fox, W. Smith-Kinnaman, H. Gao, Y. Liu, A. Mosley. Indiana University School of Medicine. B130 597.3 Regulation of RNA Polymerase Translocation by the RNA and DNA Hybridization at the Upstream Edge of the Transcription Bubble. M. Kireeva, C. Trang, G. Matevosyan, L. Lubkowska, M. Kashlev. NCI. B131 597.4 PAF53 Is Essential in Mammalian Cells: CRISPR/Cas9 Fails to Eliminate PAF53 Expression. L. Rothblum, E. Chang, K. Rothblum. OUHSC.

598. RNA BINDING PROTEINS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B132 598.1 Role of Cystines in the Structure and Function of the RNA-Binding Protein LAR. P6 E.L. Peña, L.F. Lane, E. Salas, J.M. Castro, K.A. Lewis. Texas State University. B133 598.2 Alternative Splicing of hnRNPA2/B1 by SRSF2 and Its Effects on Stress Granule Formation in Myelodysplasia. A. Ardasheva, R. Vasic, S. Halene. Juniata College and Yale University School of Medicine. B134 598.3 Effect of Histidine Rich Sequence Motifs on the RNA Binding Activity of LAR. P6 C. Toner, F.C. Betancourt, K. Lewis. Texas State University. B135 598.4 Biochemical Characterization of Evolutionary Divergent Vertebrate LARP6 Proteins. J.M. Castro, D.A. Horn, K.A. Lewis. Texas State University and Agilent Technologies. B136 598.5 Insights Into HuR RRM1-2 Tandem Domains Self-Association and mRNA Recognition. A.S. Pinheiro, C. Lixa, K.A. Jendiroba, L.T. Lima, M.T. de Magalhães, F.C. Almeida. Federal University of Rio de Janeiro, Brazil and Federal University of Minas Gerais, Brazil. B137 598.6 Understanding the Role of Post-Translational Modifications on the Splicing Activity of Two Related RNA Binding Proteins. J.M. Reynaga, J. Pina, N. Keppetipola. California State University Fullerton. B138 598.7 Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTB. P1 R.J. Ontiveros, J. Doan, E. Adams, A.L. Hernandez, D.L. Black, N.M. Keppetipola. California State University, Fullerton, University of California at Los Angeles. B139 598.8 Mechanism of PWI Domain Binding to Nucleic Acids. B.R. Szymczyna, H. Chanzu, N. Jandaghijafari, E.I. Lopez, D. Flores. Western Michigan University.

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599. RNA STRUCTURE, FOLDING AND DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B140 599.1 Thermodynamic Analysis of a 4x4 Internal Loop in Magnesium Riboswitch. E. Gilbertson. Colorado College. B141 599.2 Structural Probing of the Cap-Independent Vascular Endothelial Growth Factor Messenger RNA. W. Huang, H. Scott, W. Merrick, D. Bhattacharyya, S. Basu, D. Taylor. Case Western Reserve University and Kent State University. B142 599.3 Synthesis and Characterization of Nucleic Acid Aptamers Targeted at Aspergillus Surface Carbohydrates. J.A. Bush, M. Sheridan, D.R. Engelke, C.E. Rohlman. Albion College and The University of Michigan. B143 599.4 Unique Structures in the 3’ UTR of Blackcurrant Reversion Nepovirus Genomic RNA 1 Promote Translation Initiation. L.D. Baquero-Galvis, E. Shields, M.E. Filbin-Wong. Metropolitan State University of Denver. B144 599.5 Thermodynamic Examination of the Bulged-G Motif in the 23S Ribosomal RNA. Z. Aman. Colorado College. B145 599.6 A Cellular Non-Coding RNA Activator of Human 2′-5′-Oligoadenylate Synthetase 1 B.M. Calderon, G.L. Conn. Emory University.

600. MECHANISMS AND REGULATION OF PROTEIN SYNTHESIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B146 600.1 Analysis of Eukaryotic Translation Initiation Factor (eIF) Phosphorylation by Mass Spectrometry. K. Beglinger, N. Villa, A. Andaya, J. Leary, C. Fraser. University of California at Davis. B147 600.2 Regulation of Protein Translation Initiation by Estrogen. M.K. Holz. Yeshiva University. B148 600.3 Phosphorylation of eIF2 Directs Multiple Mechanisms of Preferential Translation for Cell Adaptation to Environmental Stress. R.C. Wek, S.K. Young, J.A. Willy, M.E. Fusakio. Indiana University School of Medicine. B149 600.4 Protein Synthesis Regulation by Soy Isoflavones Metabolite Equol in Metastatic Breast Cancer Cells. A.M. Cruz-Collazo, C. de la Parra, R.J. Schneider, S.M. Dharmawardhane. University of Puerto Rico—Medical Sciences Campus, Puerto Rico and New York University School of Medicine. B150 600.5 Antimicrobial Peptide Turns the Ribosome Into a Release Factor Trap. T. Florin, C. Maracci, M. Graf, P. Karki, D. Klepacki, M.V. Rodnina, D.N. Wilson, N. Vázquez-Laslop, A.S. Mankin. University of Illinois at Chicago, Max Planck Institute for Biophysical Chemistry, Germany, University of Munich, Germany and University of Hamburg, Germany.

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B151 600.6 Mediating Protein Synthesis in Developing Neurons: Netrin Receptor Deleted in Colorectal Cancer (DCC) Binds Eukaryotic Ribosomes to Prevent Translation of Messages Independent of Initiation Mechanism. M.E. FilbinWong, T. Gonen, J.S. Kieft. Metropolitan State University of Denver, Howard Hughes Medical Institute and University of Colorado School of Medicine. B152 600.7 Characterization of CD38 mRNA, Protein, and Enzyme Activity in the Cell Types of the Heart. J. Boslett, J.L. Zweier. Ohio State University. B153 600.8 Differentiation of Human Keratinocytes Requires Translational Control by the eIF2 Kinase GCN2. A. Collier, R. Wek, D. Spandau. Indiana University School of Medicine. B154 600.9 The N-Terminus of Secis Binding Protein 2 Is Required for Processive Selenocystine Incorporation in Selenoprotein P. M.H. Pinkerton, M. Vetick, S.P. Shetty, P.R. Copeland. Rutgers University. B155 600.10 Messenger RNA Stability Drives the Expression of Antibiotic Resistance Methyltransferase Independently of Ribosome Stalling. K. Los, M. Yap. St. Louis University School of Medicine. B156 600.11 Regulation of Protein Synthesis by PostTranslational Modification of Eukaryotic Translation Elongation Factor 1A. P. Sharma, M.K. Mateyak, D. He, W.B. Perez, T.G. Kinzy. Rutgers- RWJ Medical School. B157 600.12 IL-6 Modulates Cardiac Muscle Proteostasis and Anti-Oxidative Capacity Post-Burn. A. El Ayadi, Y. Wang, A. Prasai, M. Wetzel, A. Goullry, C. Porter, D.N. Herndon, C. Finnerty. University of Texas Medical Branch and Shriners Hospital for Children. B158 600.13 Enhancement of Transgene Production in a Vaccinia Virus-Based Expression System. B. Richard, J. Flores, B. Jacobs, J. Chaput, B. Wellensiek. Midwestern University, The Biodesign Institute, Arizona State University and Arizona State University. B159 600.14 Characterization of a Short Motif Capable of Enhancing Human Cap-Independent Translation. A.N. Juba, A. Hansen, J.C. Chaput, B.P. Wellensiek. Midwestern University, The Biodesign Institute, Arizona State University and Arizona State University.

601. PROTEIN INTERACTIONS AND BINDING (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Interactions and Binding (II), Monday, Protein Interactions and Binding (III) Tuesday B160 601.1 Effect of Transient Helicity of cMyb TAD on Its Binding Affinity to the Kix Domain of CBP/p300 A. Poosapati, W. Borcherds, M.D. Carbtree, S.L. Shammas, J. Clarke, G.W. Daughdrill. University of South Florida and University of Cambridge, United Kingdom. B161 601.2 Importance of the C-Terminal Histidine Residues of Helicobacter pylori GroES for Toll-Like Receptor 4 Binding and Interleukin-8 Cytokine Production. L. Chow, H. Lee, Y. Su, B. Huang, F. Hsieh. College of Medicine and National Taiwan Univ., Taiwan.

SUNDAY BIOCHEMISTRY B162 601.3 Distinct Liver X Receptor Alpha Residues at the Protein-Protein Interface Mediate Ligand Dependent Transactivation in Heterodimeric Contexts. S. Bedi, S.D. Rider; Jr., H.A. Hostetler. Wright State University. B163 601.4 Predictive Models of Peptide RMS Fluctuations in the Context of HLA-A*2:01 Through Sequence Alone. C. Ayres, T. Riley, S. Corcelli, B. Baker. University of Notre Dame. B164 601.5 CD47 Is Required for Activation and Clustering of the TCR/CD3/ Intraflagellar Transport Complex to the Immune Synapse. A. Nugooru, S. Kaur, S.P. Singh, D.D. Roberts. National Institutes of Health, National Cancer Institute, Virginia Commonwealth University, National Institutes of Health and National Institute of Allergy and Infectious Diseases. B165 601.6 Biophysical and Structural Characterization of Antigen Recognition by the Alloreactive HCV1406 TCR. Y.M. Wang, B.M. Baker. University of Notre Dame. B166 601.7 Effect of Allosteric Changes in MERS 3CL Protease Enzymatic Activity and Dimerization. L.S. Gonzalez, B. Anson, A. Mesecar. Purdue/Truman and Purdue University. B167 601.8 Molecular Dynamics Simulations Support Multiple Binding Sites for Phospholamban on SERCA. N. Smolin, S.L. Robia. B168 601.9 Determination of the Residues Necessary for the Self-Interaction of Atg11, a Central Organizer of the Selective Autophagy Initiation Complex. Z. Spearin, H. Cawthon, J. Smith, S.K. Backues. Eastern Michigan University. B169 601.10 Investigating the Binding Affinity of the Peptide Humanin and Its Analogs to Amyloid Beta. D.E. Esckilsen, P. Guttikonda, B.W. Iwaniec, H. Evans, M.C. Milletti, D. HeylClegg. Eastern Michigan University. B170 601.11 Activation of the H-NOX Redox Sensor in Vibrio cholerae by a Zinc Ligand Switch Mechanism. R. Mukhopadhyay, E.T. Yukl. New Mexico State University. B171 601.12 Regulation of Ankyrin-Repeat and SOCSBox Protein 9 (ASB9) in Ovarian Follicles and Identification of Binding Partners. G. Benoit, J.G. Lussier, K. Ndiaye. University of Montreal, Canada. B172 601.13 Determination of Pair-Wise Protein Interactions Between Spt7 and Drosophila melanogaster SAGA Subunits. E.E. Colon Acosta, V. Weake, R. Stegeman, A. Harris. University of Puerto Rico, Arecibo Campus, Puerto Rico and Purdue University. B173 601.14 The Impact of T Cell Receptor Docking Geometry on T Cell Signaling. J. Devlin, D. Harris, N. Singh, S. Smith, D. Kranz, B. Baker. University of Notre Dame and University of Illinois.

602. PROTEIN MODIFICATIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F

B175 602.2 Probing the Chromophore of the Green Fluorescent Protein with 4-Cyano-L-Phenylalanine. J. Piacentini, G.M. Olenginski, S.H. Brewer, C.M. Phillips-Piro. B176 602.3 Phosphorylation Regulates Apoptotic Caspase Function Through Diverse Molecular Mechanisms. J.A. Hardy, B.P. Serrano, S.J. Eron. University of Massachusetts. B177 602.4 Protein Succination: A Biomarker of Mitochondrial Stress in Adipose Tissue Inhibits Protein Function and Is Regulated by Nutrient Balance. A.M. Manuel, M. Walla, G. Piroli, N. Frizzell. University of South Carolina School of Medicine and University of South Carolina. B178 602.5 Phosphorylation of a Master Transcription Factor in Human Organogenesis Regulates Developmental Fate. Y. Chen, N.B. Phillips, M.A. Weiss. Case Western Reserve University. B179 602.6 Creating Peptide Hydrazides via Intein Splicing for Native Chemical Ligation and Protein Labeling. D.A. Santoleri, J. Liu, O. Ekanayake, S. Rozovsky. University of Delaware. B180 602.7 Role of SUMOylation in Alcohol-Induced Liver Fibrosis. M. Tomasi, C. Cossu, K. Ramani. Cedars-Sinai Medical Center. B181 602.8 Novel Physiological Targets of FicMediated Adenylylation/AMPylation. S. Mattoo, A. Sanyal. Purdue University. B182 602.9 Role of Sumoylation in Alcohol Dehydrogenase 1 (ADH1) Stability and Activity in Alcoholic Liver Disease. C. Cossu, Y. Spissu, A. Floris, M. Tomasi. Cedars-Sinai Medical Center. B183 602.10 Role of Sumoylated SOD2 in Alcoholic Liver Disease and Liver Cancer. Y. Spissu, C. Cossu, A. Floris, M. Tomasi. Cedars-Sinai Medical Center. B184 602.11 A High-Throughput Approach to Annotate the Lysine Methylome. E.M. Cornett, B.M. Dickson, K. Krajewski, M.W. Cowles, Z. Sun, S.B. Rothbart. Van Andel Research Institute, University of North Carolina and EpiCypher. B185 602.12 Posttranslational Arginylation Enzyme Ate1 Affects DNA Mutagenesis by Regulating Stress Response. A. Kumar, M.D. Birnbaum, D. Patel, W.M. Morgan, J. Singh, A. Barrientos, F. Zhang. University of Miami. B186 602.13 Inhibition of Sodium Hydrogen Exchanger 1 Palmitoylation Is Associated with Suppression of Cell Migration. M.J. Hovde, A.J. Kooiker, D.E. Rastedt, J.J. Provost, R.A. Vaughan, M.A. Wallert, J.D. Foster. University of North Dakota School of Medicine & Health Sciences, Bemidji State University and University of San Diego. B187 602.14 Obesity-Mediated Regulation of the Cardiac Acetylome. S.S. Romanick, A. Hostler, K. Schlauch, D. Quilici, Y. Feng, B. Ferguson. University of Nevada Reno. B188 602.15 NAD+ replacement Therapy with Nicotinamide Riboside Does Not Improve Cardiac Function in a Model of Mitochondrial Heart Disease. A.R. Stram, P.M. Pride, R.M. Payne. Indiana University School of Medicine.

Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B174 602.1 The Localization to PML Nuclear Bodies and Stability of TRAIP/RNF206 Are Controlled by Sumoylation. Y. Han, I. Park, H. Kim. Sungkyunkwan University, Korea, Republic of, Pasteur Korea, and Republic of Korea.

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603. PROTEIN STRUCTURE AND BIOPHYSICS (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Structure and Biophysics (II), Monday, Protein Structure and Biophysics (III), Tuesday B189 603.1 Influenza Hemagglutinin Fusion Domain by Advanced NMR Using Novel Orthagonal Refinement, BICS Curvature Measurements and Native Lipid Environments. S.T. Smrt, B. Mendis. University of Illinois at Chicago. B190 603.2 Structural Differences Associated With DNA Binding of p53 Family Member Proteins. G.R. Mavodza, Y. Fang, Z. Sherif. Howard University. B191 603.3 Ligand Induced Shift in FRET Spectrum of MDA5/LGP2 Signaling Complex. J. Corby, M. Stoneman, G. Biener, V. Raicu, D. Frick. UW Milwaukee. B192 603.4 Insights Into the Mechanism of Protein Functional Loss Upon Covalent Modification by Homocysteine Thiolactone. G.S. Sharma, L.R. Singh. Dr. B. R. Ambedkar Centre for Biomedical Research and University of Delhi, India. B193 603.5 Structure of hRpn13 at the Proteasome. X. Lu, F. Liu, U. Nowicka, V. Sridharan, M. Dyba, S.G. Tarasov, K.J. Walters. Center for Cancer Research, National Cancer Institute. B194 603.6 A Conformationally Gated Model for Serotonin 5-HT1B/1D Receptor Agonist Transport by P-Glycoprotein. L.A. Wilt, K.P. Sigdel, D. Nguyen, G.M. King, A.G. Roberts. University of Georgia and University of Missouri. B195 603.7 Significance of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase. Z. Ahmad. A.T. Still University. B196 603.8 Structural Insights Into Oxalate Biosynthetic Component. S. Rhee, J. Oh, S. Kim. Seoul Nat’l University, Republic of Korea. B197 603.9 Solution Structure of the Transmembrane Nogo-B Receptor and Insight Into Its Topological Orientation by Small Angle X-Ray Scattering Analysis. J. Holcomb, N. Spellmon, W. Shang, Q. Miao, Z. Yang. Wayne State University School of Medicine, BioCAT, Argonne National Laboratory and Medical College of Wisconsin. B198 603.10 The Importance of a Salt Bridge in FNR Transcription Factor Activity. S.G. Kazmouz, L.J. Badang, L.J. Moore. Monmouth College. B199 603.11 Thermodynamics of the Gamma B Crystallin Protein Demonstrated by T1/T2 NMR Experiments. K. Umphred-Wilson, A. Fadden, J. Zanet, K. Mathews, G. Thurston, J. Mills, L.V. Michel. Rochester Institute of Technology. B200 603.12 Structural and Functional Basis of GusRMediated Regulation of β-Glucuronidase Expression in Enterobacteriaceae Gastrointestinal Pathobionts. M.S. Little, S.J. Pellock, W.W. Walton, M.R. Redinbo. University of North Carolina at Chapel Hill. B201 603.13 Unique Solutions to a Common Problem: Understanding How I-CreI Homologs Recognize the Same DNA Target Sequence. C.R. Polkinghorn, B. Kaiser, N. Wylie, M. Tang, R. Ruff. Seattle University.

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B202 603.14 Polar Subdomain Alterations Lead to β-Helix Aggregation. D. Sweeting, D. Grilley, T. Weaver. University of Wisconsin La Crosse. B203 603.15 Probing Solvation Environments in Tt H-NOX by Site-Specific Incorporation of 4-Cyano-L-Phenylalanine. C. Kearney, L.T. Olenginski, D. Tariq, T.D. Hirn, S.H. Brewer, C.M. Phillips-Piro. Franklin & Marshall College. B204 603.16 Labilization of the Cobalt-Carbon Bond in Vitamin B12 Bound to Adenosyltransferase. G.C. Campanello, U. Twahir, T. Brunold, K. Warncke, R. Banerjee. University of Michigan, Emory University and University of Wisconsin. B205 603.17 Structural Changes in the Nickel-Responsive Regulator NikR from Helicobacter pylori K.A. Baksh, J. Wong, T. Pham, D.B. Zamble. University of Toronto, Canada. B206 603.18 SAXS: A Versatile Tool to Study Biological Macromolecules in Solution. W. Ma, S. Chakravarthy, W. Shang, T. Irving. Illinois Institute of Technology. B207 603.19 Targeting the Hendra Virus Fusion Protein Transmembrane Domain to Inhibit Viral Fusion. C. Barrett, S. Webb, R. Dutch. University of Kentucky. B208 603.20 Exploring the Structural Impact of Unnatural Amino Acids on Protein Structure. N.S. Savidge, N. Maurici, S.H. Brewer, C.M. Phillips-Piro. Franklin and Marshall College. B209 603.21 Role of the Transmembrane Domain of Mucin 1 in Nuclear Localization. G.J. O’Connor, C. Freeman, E. Li. Saint Joseph’s University. B210 603.22 Biochemical and Biophysical Comparison of the Human and Drosophila melanogaster I Kappa B Kinase Protein Complexes Suggest Structural Conservation. W.E. Rogers, T. Huxford. San Diego State University and University of California—San Diego. B211 603.23 Prediction of the Entamoeba histolytica Alcohol Dehydrogenase 2 (EhADH2) Protein Structure Using Bioinformatics Tools. K. Lowerre, C. Hemme, A. Espinosa. Roger Williams University and University of Rhode Island. B212 603.24 New ABCG2 Homology Model Reveals Importance of C-Terminus in Protein Trafficking. J. Cui, H. Sayed, J. Huang, O.M. Woodward. Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, People’s Republic of China, and University of Maryland School of Medicine.

604. PROTEIN FOLDING AND CHAPERONES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B213 604.1 Heat Shock Protein 90 Is Critical for Plasmodium Parasite Liver Stage Development. A.I. Keim, D. Posfai, T.A. Haystead, E.R. Derbyshire. Duke University. B214 604.2 Understanding the Influence of TranslationElongation Kinetics on Protein Structure and Function. E.P. O’Brien. Penn State University. B215 604.3 The Structural Basis for Polypeptide Translocation by the HSP104 Disaggregase. D.R. Southworth, A. Yokom, S. Gates, M. Jackerel, J. Shorter. University of Michigan and University of Pennsylvania.

SUNDAY BIOCHEMISTRY B216 604.4 Engineering Potentiated Hsp104 Variants with Enhanced Substrate-Specificity to Counter Neurodegeneration. K.L. Mack, J. Shorter. Perelman School of Medicine at the University of Pennsylvania. B217 604.5 Inorganic Polyphosphate: A Mediator of Protein Folding in Osteoblasts via Interaction with Cyclophilin B. M. Khong, L. Li, C.Y. Lang, J.A. Tanner. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Neuroscience Research Institute, Peking University, People’s Republic of China. B218 604.6 Chaperoning the Proteome. W.A. Houry. University of Toronto, Canada. B219 604.7 Redox Modification of Fes1 and Its Role in Cellular Oxidative Stress Response. E. Nicklow, C. Sevier. Cornell University. B220 604.8 Periplasmic Chaperones Play Hot Potato with Unfolded Outer Membrane Proteins. K.G. Fleming, S.M. Costello, A.M. Plummer, P.J. Fleming. Johns Hopkins University. B221 604.9 Characterization of Sup35, Rnq1, and Ure2 Cotranslational Prion Aggregation in Saccharomyces cerevisiae. B.T. Allwein. Ursinus College. B222 604.10 Inter-Domain Interactions in Nascent Polypeptides Interfere with Productive Protein Folding. K. Liu, K. Maciuba, C. Kaiser. Johns Hopkins University. B223 604.11 Defining Functional Variation of Diverse Hsp104 Homologues. Z. March, J. Shorter. Perelman School of Medicine at the University of Pennsylvania. B224 604.12 The Ribosome-Associated Complex Suppresses [PSI+] Prion Formation in Yeast. C. Kelly, T. Tessitore, J. Taddeo, D.M. Cameron. Ursinus College. B225 604.13 The Role of Rr-Resident Lectin Chaperone UGT1 in MHC Class I Peptide Loading. N. Arshad, P. Cresswell. Yale University School of Medicine. B226 604.14 Allosteric Landscape of a Stress-Inducible Human Hsp70 Molecular Chaperone. W. Meng, E.M. Clerico, N. McArthur, L.M. Gierasch. University of Massachusetts and Amherst. B227 604.15 Functional Characterization of Natural Single Nucleotide Polymorphisms Found on HSPA1A, the Major Stress Inducible 70 kDa Heat Shock Gene in Humans. R. Oliverio, N. Nikolaidis. California State University at Fullerton. B228 604.16 Dual Function of the Trigger Factor Chaperone in Nascent Protein Folding. C. Kaiser, K. Maciuba, K. Liu. Johns Hopkins University. B229 604.17 Defining Interactomes of Wild-Type Versus Misfolding Type I Collagen Variants in Osteogenesis Imperfecta. D.N. Doan, A.S. DiChiara, A. Del Rosario, M.D. Shoulders. MIT. B230 604.18 Evolution and Natural Variation of HSPA1A, the Major Stress Inducible Gene, in Humans. P. Nguyen, B. Kdeiss, S. Ord, K. Hess, R. Oliverio, N. Nikolaidis. California State University at Fullerton. B231 604.19 Identification of a Pharmaceutical Therapeutic for Nod2, a Protein Mutated in Crohn’s Disease, Through Development of a Screen Using Split GFP Complementation. H.C. Wastyk, C. Hou, C. Grimes. University of Delaware. B232 604.20 Loss of Sil1, an ER Co-Chaperone, Causes an Age-Dependent Collapse of Skeletal Muscle Proteostasis, Affecting Pathways Critical for Muscle Physiology. V.P. Ichhaporia, P. Vogel, S. Frase, L. Horner, L.M. Hendershot. St. Jude Children’s Research Hospital and The University of Tennessee Health Science Center.

B233 604.21 New Insights from High-Throughput Biophysical Screening of Protein-Sequence and CodingSequence Libraries. B. Allen. Penn State University.

605. BIOMOLECULAR CATALYSIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B234 605.1 Thiol Addition to Conjugated Nitrolinoleic Acid. B. Alvarez, L. Turell, D.A. Vitturi, E.L. Coitiño, L. Lebrato, M.N. Moller, C. Sagasti, S.R. Salvatore, S.R. Woodcock, F.J. Schopfer. Universidad de la Republica, Uruguay, Uruguay and University of Pittsburgh. B235 605.2 Characterization of Recombinant Fructose1,6-Bisphosphatase (FBPase) Gene Mutations: Insights Into Modulation of FBPase Activity Through Gene Mutation. G. Topaz, V. Epiter-Smith, M. Emad, V. Ford, J. Daley, C. Silva, M. Subramanian, H. Sosa, K. Stieglitz. Roxbury Community College. B236 605.3 α-Effect Furnishes a Mechanistic Bypass for General Base Catalysis in Hedgehog Protein Autoprocessing. B. Callahan, J.L. Giner, D. Ciulla, M. Jorgenson. Binghamton University and SUNY Environmental Science and Forestry. B237 605.4 Protein-Based Models of Nickel Metalloenzymes. H.S. Shafaat, A.C. Manesis, C.R. Schneider, M.C. O’Connor. The Ohio State University.

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606. ENZYME MECHANISMS, KINETICS AND ENERGETICS (I) Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Enzyme Mechanisms, Kinetics and Energetics (II), Monday B238 606.1 Evolutionary Insights Into Oxygen Sensing. T. Liu. University of Oxford, United Kingdom. B239 606.2 Metal Drives Chemistry: Dual-Function of Acireductone Dioxygenase Enzymes. A.R. Deshpande, K. Wagenpfeil, T.C. Pochapsky, G. Petsko, D. Ringe. Brandeis University, Allena Pharmaceuticals and Weil Cornell Medical School. B240 606.3 Inhibition of Acetyl Cholinesterase Extracted from Five Parts of the Brain by 5,6 Dihydroxytryptamine. M.H. Osman. Medical Research Institute, Egypt. B241 606.4 Defining Energetic Homeostasis in Toxoplasma gondii R.D. Murphy, A. Dhara, A.P. Sinai, M.S. Gentry. University of Kentucky. B242 606.5 Preliminary Characterization of Pyrimidine Biosynthesis Protein Aspartate Transcarbamoylase (ATC) in Pseudomonas aeruginosa C. Patel, F.A. Hachem, A. Vaishnav, B.F. Edwards, H.G. Evans, D.R. Evans. Wayne State University School of Medicine and Eastern Michigan University.

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BIOCHEMISTRY SUNDAY B243 606.6 Novel Thymidine Hypermodifications in Viruses Encoding a 5-Hydroxymethyl-5′-Deoxyuridine DNA Kinase. P.R. Weigele, S. Müller, Y. Lee, S. Walsh, C. Guan, N. Dai, I. Correa. New England Biolabs. B244 606.7 HLA–DM Senses Peptide-MHC Class II Interactions Throughout the Peptide Binding Groove. E. ReyesVargas, A.P. Barker, Z. Zhou, X. He, P.E. Jensen. University of Utah and ARUP Laboratories. B245 606.8 Examining the Mechanism of Egt2 in Ergothioneine Biosynthesis. K.R. Kathuria, S. Irani, P. Liu, Y. Zhang. The University of Texas at Austin and Boston University. B246 606.9 Aspartate Cyclization: The “Aspartic Acid Effect” in Pyrococcus abyssi and Deep-Sea Enzyme Pressure Studies. C.J. Minteer, K.M. Colelli, J.N. Reitter, K.V. Mills. College of the Holy Cross. B247 606.10 Investigating the Catalytic Cycle and Active Site Residues of the Biodesulfurizing Enzyme, Dibenzothiophene Monooxygenase, DszC. S.A. Jirde, L. Gonzalez-Osorio, K. Eberle, J. Vey. California State University at Northridge. B248 606.11 The E. coli and Human Nudix Hydrolases NudC and NUDT12 Cleave Damaged NADH. A. Ray, B.A. Beaupre, G.R. Moran, D.N. Frick. University of Wisconsin—Milwaukee. B249 606.12 Salt-Dependent Protein Splicing of the Intein in the Haloquadratum walsbyi DNA Polymerase. D.A. Reidy. College of the Holy Cross. B250 606.13 Differential Protein Splicing of Salt Dependent Inteins from Haloquadratum walsybi A.K. Lynch, S. Amunya, J. Reitter, K. Mills. College of the Holy Cross. B251 606.14 Investigation of the Third Step of Protein Splicing in Two Similar Cyanobacterial Inteins. C.K. Ramsoomair, A.E. Yakely, J. Reitter, K. Mills. College of the Holy Cross. B252 606.15 A Structural Investigation and Splicing Study of Inteins from Halobacteria. W. Zhang, A.K. Lynch, A.O. Gomez, J.N. Reitter, K.V. Mills. College of the Holy Cross. B253 606.16 Structural and Biochemical Analyses of Alcohol Dehydrogenase E Enzymes from Entamoeba invadens IP-1, E. invadens VK-1:NS and E. dispar M. Gabrielle, J. Leito, A. Espinosa. Roger Williams University. B254 606.17 Role of Cys292 in Coupling ATP Hydrolysis to RNA Unwinding Catalyzed by the Hepatitis C Virus Helicase. M.M. Yerukhimovich, D. Frick, C. Marohnic. University of Wisconsin Milwaukee and Abbott Laboratories. B255 606.18 Purification and Characterization of Flavin Reductase, DszD, from Rhodococcus erythropolis G. Mendez. California State University at Northridge. B256 606.19 Conditional Protein Splicing of Inteins from Extremophiles. A. Gomez, K.V. Mills. College of the Holy Cross. B257 606.20 Investigating Metallocofactor Assembly and Enzymatic Capability In the Novel Mn/Fe Lipid-Binding Oxidases. E.K. Miller, N.E. Trivelas, P.T. Maugeri, H.S. Shafaat. The Ohio State University.

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607. STRUCTURAL DYNAMICS OF ENZYMES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B258 607.1 Functional Characterization of Three GH10 Xylanases. J. Park, E. Glasgow, B.G. Fox. Winthrop University and University of Wisconsin—Madison. B259 607.2 Using Dynamics and Structure to Understand Allostery in Signaling Enzymes. W. Peti. University of Arizona. B260 607.3 Understanding the Allosteric Control of Kinase Activation by Phosphorylation-Regulated Protein Dynamics. D.B. Iverson, N. Ahn. University of Colorado and Boulder. B261 607.4 Probing Carrier Domain Movement and Location During Catalytic Turnover by Pyruvate Carboxylase. M. St Maurice, Y. Liu, J.H. Hakala. Marquette University. B262 607.5 Measuring the Positioning and Translocation of the Swinging-Arm Domain of Pyruvate Carboxylase. J.H. Hakala, M. St. Maurice. Marquette University. B263 607.6 Unmixing Enzyme Allostery. S. Meisburger, N. Ando, A.B. Taylor, C.A. Kahn, S. Zhang, P.F. Fitzpatrick. Princeton University and University of Texas Health Science Center. B264 607.7 A Novel, Green Synthesis of Deuterium Labeled Compounds. D. Kadish, A. Kokel, M. Torok, B. Torok. University of Massachusetts and Boston. B265 607.8 A Structure-Based Mechanism for Oxidative Decarboxylation Reactions Mediated by Amino Acids and Heme Propionates. A.I. Celis. Montana State University. B266 607.9 Deciphering the Logic of Natural Product Biosynthesis. B. Li. University of North Carolina at Chapel Hill.

608. CHEMICAL BIOLOGY, DRUG DISCOVERY AND BIOANALYTICAL METHODS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B267 608.1 An Essential Oil Blend Specifically Enhances Immune Responses in Human Cancerous Co-Cultures. X. Han, T. Parker. doTERRA International. B268 608.2 Drugging the Undruggable Steroid Receptor Coactivators. J. Wang. Baylor College of Medicine. B269 608.3 Characterization of a Cardiac Drug-Inactivating Enzyme from the Prominent Human Gut Microbe, Eggerthella lenta. N. Koppel, J. Bisanz, P. Turnbaugh, E.P. Balskus. Harvard University and UCSF.

SUNDAY BIOCHEMISTRY B270 608.4 Synthesis, Antimicrobial Activity and Molecular Docking Studies of Novel Bioactive Fused Heterocyclic Systems. S. Govori Odai, A. Haziri, H. Ibrahimi, K. Ademi, N. Neziraj. University of Prishtina, Yugoslavia. B271 608.5 PTEN Regulation by WWP2. Z. Chen, D. Dempsey, W. Xu, X. Li, D. Dempsey, P. Devreotes, C. Wolberger, S. Gabelli, P. Cole. Johns Hopkins University. B272 608.6 Inorganic Arsenic Bioaccessibility/ Bioavailability from Cooked Rice Using in Vitro Digestion/ Caco-2 Cell Model. K. Lee, S. Lee. Korea University, Republic of Korea. B273 608.7 Total Synthesis, Antileishmanial and Anticancer Activity of the Acetylenic Fatty Acids 6-Hexadecynoic, 10-Phenyl-6-Decynoic, and 10-Cyclohexyl-6-Decynoic Acids. E. Álvarez, N. Carballeira, C. Morales, Y. Delgado, A. Tinoco, R. Reguera, R. Álvarez, R. Balaña. University of Puerto Rico, Rio Piedras Campus, Puerto Rico, University of Leon and Vegazana Campus, Spain. B274 608.8 Carbohydrate-Linked Cisplatin Analogue: Reactivity Studies with RNA and DNA. S.D. Thalalla Gamage, N. Muthunayake, A. Sonousi, D. Crich, C. Chow. Wayne State University. B275 608.9 Affinity Ligand for the Separation of Glycosylated Proteins from Non-Glycosylated Proteins. A. Gunter, C. Mammoser, S. Dhar, L. Rowe. Valparaiso University. B276 608.10 Development of a Microscopic Method for the Exposure of Hemoglobin C. K.L. Schmidt, T.R. Randolph. Saint Louis University. B277 608.11 Mechanistic Comparison of Structurally Divergent Transcriptional Coactivators Through Covalent Activator-Coactivator Complexes. A.R. Henderson, M. Beyersdorf, N. Foster, K. Sanford, M. Henley, A. Mapp. University of Michigan. B278 608.12 Development of Novel Small Molecule Antibiotics Against a Conserved RNA Element in Gram-Positive Bacteria. V.Y. Väre, K.M. Frohlich, G. Todd, J. Bell, P.F. Agris. SUNY at Albany and The RNA Institute. B279 608.13 Mechanism and in Vivo Activity of a Covalent Inhibitor of ERK Docking. K.N. Dalby, E.V. Anslyn, D. ZamoraOlivares, T. Kaoud. University of Texas at Austin. B280 608.14 Earmarking Target-Specific Redox Trajectories for Wound Healing in Zebrafish. Y. Aye. Cornell University and Weill Cornell Medical College.

609. DRUG SCREENING AND DEVELOPMENT Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B281 609.1 Simple Model for Screening Anti-Cell-Clumping Reagents: Acids. G. Zem, K. Pastrano, A. Strelnicova, M. Cabrera, J. Cuevas, L. Espinoza, C. Voskanian, R. Keshishian, S. Sorayazadeh, B. Alvarado, S. Pizana, A. Weisman-McCarley, K. DeGuzman, A. Pourkhayat, K. Ellikkal, A. Darmali, S. Oppenheimer. California State University at Northridge.

B282 609.2 Determining the LC50 of a Novel Metap Inhibitor in Lung Carcinoma Cells. A.P. Addison, N.F. Hayden, E. Perli, E. Erwin, G. Chow, L. Vu, S. Bhalla, N. Condic, O. Olaleye, R. Rosell. University of St. Thomas and Texas Southern University. B283 609.3 Optimization of a Medium-Throughput Cathepsin K Inhibition Assay for NAAA Inhibitors. E.R. Golden, C. Miyabe, J. Wood, M. Malamas, S. Alapafuja, A. Makriyannis. Northeastern University. B284 609.4 Assessing the Effects of ErbB2 Kinase Inhibition in Conjunction with Broad Spectrum Anti-Cancer Treatments. C. Tremper, A.R. Matha, C.E. Taylor. Mercyhurst University. B285 609.5 Identification of Yeast Deletions Strains That Alter the Efficacy of Antifungal Drugs. E. Bataba, N.D. Serratore, S.D. Briggs. Georgia State University and Purdue University. B286 609.6 The PepSAVI-MS Pipeline for Natural Product Bioactive Peptide Discovery. C.L. Kirkpatrick, D. Pritchard, N. Parsley, Y. Liu, D.W. Hoskin, L.N. Shaw, L.M. Hicks. University of North Carolina, Chapel Hill, Dalhousie University, Canada and University of South Florida. B287 609.7 A Cell-Based inhibitor Screening Platform for S-Adenosylmethionine Synthetase. G. Parungao, M. Dziobak, R. Blumenthal, R. Viola. The University of Toledo. B288 609.8 Viable Strategy for Inhibition of Death Receptor 5 Signaling by Disrupting Receptor-Receptor Interactions. N. Vunnam, C. Lo, B.D. Grant, D.D. Thomas, J.N. Sachs. University of Minnesota. B289 609.9 Improving the Sensitivity of P-Glycoprotein to Drug-Like Inhibitors in ATPase Assays and ESR Studies. G. Chen, J. Ballou-Crawford, J.G. Wise, P.D. Vogel. Dept. of Biological Sciences and the Center for Drug Discovery, Design and Delivery and Southern Methodist University. B290 609.10 New Strategies for the Expression of Human P-Glycoprotein (MDR1) in the Yeast Pichia pastoris. M.C. de Oliveira, C.A. Lavigne, H.A. Thornton, B.M. Tran, J.G. Wise, P.D. Vogel. Southern Methodist University. B291 609.11 Inhibition of Tumor Necrosis Factor Receptor 1 Signaling by Small Molecules. C. Lo, N. Vunnam, A. Lewis, T. Chiu, B. Brummel, T. Schaaf, B. Grant, P. Bawaskar, D. Thomas, J. Sachs. University of Minnesota, Fluorescence Innovations Inc and Photonic Pharma LLC. B292 609.12 Elucidation of the Cell Death Pathways Induced by Aqueous-Stable Titanium(IV) Compounds as Potential Anticancer Agents. Y. Delgado, A. Vázquez, M. Kowaleff, M. Saxena, Z. Torres, A. Tinoco. University of Puerto Rico Rio Piedras Campus and City University of New York. B293 609.13 In Vivo Drug Discovery for Progressive Supranuclear Palsy Using a Novel Zebrafish Model. E.A. Burton, Q. Bai. University of Pittsburgh. B294 609.14 Acetaminophen Hepatotoxicity Testing Using 3D Rat Hepatocyte Cultures. V. Paliwal, M. Clapham. Milwaukee Sch. Engineering and Drake University. B295 609.15 The Antimicrobial Property of the Acetone Extract of Cola acuminate. B.J. Thomas, C.M. Telles. Southern University and A&M College. B296 609.16 Determining the Correlation Between Drosophila melanogaster Toluene Exposure and the Resulting Toxicity Effects on Fly Survival and Fecundity. V. Trivino, M. MacGregor, T. Nguyen, B. Nunez, Z. Lodhra, L. Castillo, B. Luu, R. Rosell, E. Ledesma. University of St Thomas.

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610. PROTEIN AND PEPTIDE CHEMISTRY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B297 610.1 Enzyme-Catalyzed Expressed Protein Ligation. S. Henager, N. Chu, Z. Chen, D. Bolduc, D. Dempsey, Y. Hwang, J. Wells, P. Cole. Johns Hopkins University and University of California at San Francisco. B298 610.2 Effect of Bleaching Products on Proteins of Teeth. R. Frazier, A. Panah, K. Keenan. Stockton University. B299 610.3 Effect of Bleaching Products on the Collagen of Teeth. C. Cavallaro, C. Schiliro, K. Keenan. Stockton University. B300 610.4 Anti-Cancer Properties of the Antimicrobial Peptide CDT on A549 Lung Cancer Cells. N. Hendrickson, A. Eitel, M. Jujjavarapu, J. Guthrie, H. Evans, D. Heyl-Clegg. Eastern Michigan University. B301 610.5 Disruption of the Dopamine D1/D2 Heteromer Using Synthetic Peptides. M. Champion, A. Baraka, H. Evans, D. Heyl-Clegg. Eastern Michigan University. B302 610.6 Analysis of the Stability of Natural and Unnatural Amino Acids in Extraterrestrial Conditions. C. Mammoser, B. Brown, S. Dhar, L. Rowe. Valparaiso University and Ivy Tech Community College. B303 610.7 Characterizing the Impact of the Highly Endosmolytic Cell-Penetrating Peptide, dfTAT, on Human Cells. H. Kondow. Texas A&M University. B304 610.8 Peptide Facilitated Intracellular Delivery of Quantum Dots for Live-Cell Imaging. C.I. Rivera Vera. University of Illinois at Chicago. B305 610.9 An Interdisciplinary Investigation of Antimicrobial Peptides. R.R. Wadhwa, R. Stevens-Truss. Kalamazoo College. B306 610.10 Targeting mER and GLP1R for the Treatment of Atherosclerosis and Type II Diabetes. J. Du, J.P. Issa, K. Kumar. Tufts University.

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611. SYSTEMS BIOLOGY TECHNOLOGIES AND APPLICATIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B307 611.1 Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. K. Liang, A.G. Volk, J.S. Haug, S.A. Marshall, A.R. Woodfin, E.T. Bartom, J.M. Gilmore, L. Florens, M.P. Washburn, K.D. Sullivan, J.M. Espinosa, J. Cannova, J. Zhang, E.R. Smith, J.D. Crispino, A. Shilatifard. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Stowers Institute for Medical Research, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Oncology Institute, Loyola University Chicago, Department of Pathology, Loyola University Chicago, Robert H. Lurie Comprehensive Cancer Center and Northwestern University Feinberg School of Medicine. B308 611.2 A Biosensing Soft Robot: Integrating Chemical and Optical Responsive Synthetic Cells with Soft Robotics. K. Justus, D. Lewis, C. Majidi, P. LeDuc, C. Tan. Carnegie Mellon University, University of California at Davis. B309 611.3 Lasertherapy After Induction of Myocardial Infarction by Coronary Artery Occlusion in Rats: A Genetic Signature. R.S. Feliciano, M.T. Manchini, E.T. Santana, J.V. Maretti, L.I. Caproni, E. Antonio, A.J. Serra, P.J. Tucci, J.A. Silva Jr. UNINOVE, Brazil, Universidade Nove de Julho, Brazil and UNIFESP, Brazil. B310 611.4 Optimization of Reconstituted High Density Lipoprotein (rHDL) Nanoparticles (NPs) for Short-Interfering RNA (siRNA) Delivery. L. Mooberry, N. Sabnis, A. Lacko. University of North Texas Health Science Center. B311 611.5 Delivery of siRNA Using Cationic Polymeric Nanoparticles to Understand the Localization and Function of GABAergic Neurotransmission in Planaria. K. Klasen, H. Ginter, S. Shankar, L. Ramakrishnan. St. Cloud State University. B312 611.6 Using CRISPR Technology to Edit the F508 Deletion of the Cystic Fibrosis Transmembrane Regulator Gene. K. Heavenor, J. Roecklein-Canfield. Simmons College.

SUNDAY BIOCHEMISTRY

612. GENOMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B313 612.1 HLA-DQ1 Alpha and Beta Genotypes Associated with Non-Celiac Gluten Sensitivity. M. Maki, D. Caporale. University of Wisconsin-Stevens Point. B314 612.2 Molecular Genotyping of Transposable Element Insertions in a Population of Uniform Mu Events. G.A. Arroyo Martinez, N. Springer. University of Puerto Rico at Ponce and University of Minnesota. B315 612.3 DC STAMP Domain: Intercompatibility Between SPE-42 and Other Proteins. I.S. Okeke. University of Alabama at Birmingham. B316 612.4 Factors That Differentiate Traumatic Brain Injury (TBI) Patients from Post-Traumatic Stress Disorder (PTSD) Patients Among Operation Enduring Freedom/ Operation Iraqi Freedom (OEF/OIF) Veterans. S. Miller, A. Gautam, N. Chakraborty, B. Sowe, A. Hoke, R. Yang, R. Hammamieh, M. Jett. The Geneva Foundation, USACEHR and Frederick National Laboratory for Cancer Research. B317 612.5 Characterization of a Plasmid Isolated from Enterococcus faecalis Found in the Fecal Material of a Blue Whale. R. McLaughlin, R. Kopanic. Gateway Technical College. B318 612.6 Validation of Single Nucleotide Polymorphisms in Physcomitrella patens. K. Adler, K.A. Hicks. Kenyon College. B319 612.7 Analysis of the Rates of Transcriptional Coupling and Translational Fusion Between Hydroxylase and Rubredoxin Subunits of Alkane Monooxygenase in Bacterial Genomes. H. Masuda, M. Rikard, P.R. Tupa. Indiana University Kokomo. B320 612.8 Unique Transposon Genome Rearrangements Identified in Elizabethkingia anophelis Outbreak Strains in the Midwest US. R. Flores, N. Torres, J. Matts, J. Gustafson, P. Canaan, P. Hoyt. Oklahoma State University. B321 612.9 Deciphering the Gene Expression Pattern from Human Blood Samples Collected in Multiple Collection Tubes. A. Hoke, A. Gautam, D. Donahue, S. Miller, S. Srinivasan, L. Detwiler, J. Lynch, M. Levangie, B. Sowe, R. Hammamieh, M. Jett. The Geneva Foundation, USACEHR and US Army Center for Environmental Health Research. B322 612.10 Using Transcriptomics for Biomarker Discovery Enabling High-Throughput Drug Screening of iPSCCardiomyocytes Modeling a Cardiomyopathy. T.J. Rowland, S.I. Hashem, K. Jones, A.J. Bonham, S. Jett, E. Adler, D. LaBarbera, L. Mestroni, M. Taylor. University of Colorado Denver Anschutz Medical Campus, University of California San Diego and Metropolitan State University of Denver. B323 612.11 An Investigation of the Oxidatively Damaged Transcriptome in the Human Neuronal Cells. P. Kharel, V. Gadepalli, A. Chattopadhyay, J. McDonough, S. Basu. Kent State University, Virginia Commonwealth University and University of Pittsburgh.

613. PHARMACOGENOMICS AND TOXICOGENOMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B324 613.1 Tox21 Enricher: Web-Based Chemical and Functional Enrichment Analysis Tool for Tox21 Toxicity Screening Platform. J. Hur, L. Danes, D. Krout, J. Hsieh, S. Auerbach. University of North Dakota and National Institute of Environmental Health Sciences. B325 613.2 Transcriptional and Translational Effects of Developmental Ethanol on Thyroid Function of Zebrafish. A.J. Holderman, R.C. Lawrence. Viterbo University. B326 613.3 Liver and Serum miRNAs in Toxic Liver Fibrosis. M.G. Permenter, D.L. Ippolito, V.A. Trabosh. Excet at US Army Center for Environmental Health Research and US Army Center for Environmental Health Research. B327 613.4 High Resolution Melting Analysis for the Study of Single Nucleotide Polymorphisms. G. Beuschel, C. Diez. Lawrence Technological University.

614. SIGNAL TRANSDUCTION AND CELLULAR REGULATION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F

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Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B328 614.1 Assessing Social Phenotypes of M. xanthus Following Homologous Recombination of Arg-Kinase Genes. M. Grady, D. Fraga, S. Kratt. College of Wooster. B329 614.2 CARMA2sh and Its Psoriasis-Linked Variants Regulate Inflammatory Pathways in Human Keratinocytes. I. Scudiero, P. Mazzone, G. Telesio, M. Pizzulo, P. Vito. Biogem S.c.a.r.l., Italy and Università degli Studi del Sannio, Italy. B330 614.3 Melatonin Modifies Peripheral Blood Cell Oscillators in Humans. E. Kostovski, E. Frigato, A. Dahm, G. Skretting, M. Mowinkel, P.M. Sandset, P.O. Iversen, C. Bertolucci. Clinical Medicine, University of Oslo, Norway, Sunnaas Rehabilitation Hospital, Norway, University of Ferrara, Italy, Oslo University Hospital, Norway, Akershus University Hospital, Norway and University of Oslo, Norway. B331 614.4 A Novel Role for Flotillin-1 in H-Ras-Regulated Breast Cancer Aggressiveness. A. Moon, M. Koh, H. Yong, E. Kim, H. Son, Y. Jeon, J. Hwang, M. Kim, Y. Cha, W. Choi, D. Noh, K. Lee, K. Kim, J. Lee, H. Kim, H. Kim, H. Kim, E. Kim, S. Park, H. Kim, W. Moon, H.C. Kim. Duksung Women’s University, Republic of Korea, Konkuk University, Republic of Korea, Seoul National University, Republic of Korea, Inha University, Republic of Korea, Seoul National University Bundang Hospital, Republic of Korea, and Wayne State University.

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BIOCHEMISTRY SUNDAY B332 614.5 Small Size of Membrane-Tethered Ligands Regulates Kinase-Phosphatase Segregation in Gamma/ Delta TCR Triggering. K. Choudhuri. University of Michigan Medical School. B333 614.6 Multi-Generational Silencing Dynamics Control Cell Aging. N. Hao, Y. Li, M. Jin, R. O’Laughlin, L. Tsimring, L. Pillus, J. Hasty. University of California San Diego. B334 614.7 TAK1/TRAF6 Signalling in Regulation of Skeletal Muscle Mass. A. Kumar, S.M. Hindi. University of Louisville School of Medicine. B335 614.8 General Amino Acid Control and 14-33 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Intracellular Gln3 and Gat1 Localization. T.G. Cooper, J.J. Tate, D. Buford, R. Rai. University of Tennessee Health Science Center. B336 614.9 Loss of MyoD Transdifferentiate Myoblasts Into Brown Adipocytes. C. Wang, W. Liu, Y. Nie, F. Yue, S. Kuang. Purdue University. B337 614.10 Novel Responsibilities for PKA Regulatory Subunits: Regulating Cell Migration Through the Assembly of a P-Rex1-Based Signaling Platform. S.R. Adame García, R.D. Cervantes-Villagrana, A. Castillo-Kauil, L. Chávez-Vargas, S.S. Taylor, G. Reyes-Cruz, J. Vázquez-Prado. CINVESTAV, Mexico and UCSD. B338 614.11 MiRNA-21 Mediates the Antiangiogenic Activity of Metformin Through Targeting PTEN and SMAD7 Expression and PI3K/AKT Pathway. M. Luo, X. Tan, Q. Wan, J. Wu. Drug Discovery Reseach Center, Southwest Medical University, People’s Republic of China, University of Missouri, Department of Endocrinology, The First Affiliated Hospital, Southwest Medical University, People’s Republic of China. B339 614.12 Elucidation of Molecular Signaling Battles Between the Eukaryotic Host and a Bacterial Pathogen. K. Orth, M. de Souza Santos, D. Salomon. HHMI, UT Southwestern Medical Center and UT Southwestern Medical Center. B340 614.13 Ras1 Phosphorylation and Its Role in Nutrient Signaling. S. Sethupathi, X. Jin, S. Starke, Y. Li, G. Kung, Y. Wang. Saint Louis University and St. Louis University. B341 614.14 Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells. F. Yue, P. Bi, C. Wang, J. Li, X. Liu, S. Kuang. Purdue University. B342 614.15 NOSTRIN Regulates Gene Signatures, Pleiotropic Functions and NFκB-TRAF6 Signaling Axis of Endothelial Cells: Implications in Intrauterine Growth Restriction. S. Chakraborty, R. Ain. CSIR-Indian Institute of Chemical Biology, India. B343 614.16 Dissecting JADE1 Pathway in the Regulation of Cytokinesis. M.V. Panchenko, B. Shao. Boston University School of Medicine. B344 614.17 Nanoparticles Mimic Exosomes and Attenuate Growth Factor-Induced Cell Migration in Melanoma Cells. B.P. Gallant, M. Clark, A. Madigan, Y. Wan, W. Zhang, H. Lu. Providence College, Guiyang Medical University, People’s Republic of China. B345 614.18 Modulation of MEK/ERK and mTOR Pathways by Na+-K+-ATPase and AMPK Inhibitors in Ovarian Cancer Cells. M.P. Clark, A. Madigan, B.P. Gallant, W. Zhang, H. Lu, Y. Wan. Providence College, Guiyang Medical University, People’s Republic of China.

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B346 614.19 Activation of the E3 Ligase Cbl by Neutrophil Cathepsin G Impairs CXC Chemokine Receptor 4 Signaling in Cardiomyocyte Degeneration. S. Shukla, K. Sikder, A. Sarkar, W. Liu, K. Rafiq. Thomas Jefferson Univerasity, Shanghai Tenth People’s Hospital, People’s Republic of China. B347 614.20 O-GlcNAc Regulates CD4+ T Cell Differentiation. M. Machacek, J. Li, T. Li, C. Slawson, P. Fields. University of Kansas Medical Center. B348 614.21 Disruption of the Cereblon Gene Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice. K. Lee, Y. Koo, C. Lee, C. Yoo. Seoul National University Hospital, Republic of Korea. B349 614.22 Determining the Link Between Mammalian p38 Stress Kinase Pathway and Peroxisomes. R. Singh, C. Chrestensen. Kennesaw State University. B350 614.23 Exosomes-Mediated mTOR Activation Is Involved in Ovarian Cancer Cell Aggression and Migration. A.P. Madigan, B. Gallant, M. Clark, Y. Wan, W. Zhang, H. Lu. Providence College, Guiyang Medical University, People’s Republic of China. B351 614.24 A Filamin Phosphorylation Gateway to GPCR Function. S. Ithychanda, K. Dou, S. Karnik, J. Qin. Cleveland Clinic. B352 614.25 Chronic Low-Grade Inflammation in Obesity and Diabetes Associated Colorectal Cancer Development. N. Kumar, J. Mishra, P. Kumar. Texas A&M University. B353 614.26 An Investigation of Sex Difference in Microglia Morphology and Function. J. Lawrence, A. Turano, J. Schwarz. University of Delaware. B354 614.27 The Yeast Claudin Dcv1 Is Essential for the Maintenance of Distinct Membrane Domains and Polarized Mating Functions. M.E. Sukumar, D.E. Stone. University of Illinois at Chicago. B355 614.28 PASsing on Signals: Activation of PAS Kinase by mTOR Orchestrates Epigenetic Processes of Stem Cell Differentiation. C.K. Kikani, X. Wu, J. Rutter. University of Utah School of Medicine. B356 614.29 The Effect of Proline Rich Tyrosine Kinase 2 Activity on the Na+-H+ Exchanger Isoform 1 Regulation of Cell Proliferation and Migration. K.P. Bagnell, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B357 614.30 The Phosphorylation of the Na+-H+ Exchanger Isoform I (NHE1) and Its Role in the Regulation of Cell Proliferation and Migration. T.M. Smith, J.J. Provost, M.A. Wallert. Bemidji State University and University of San Diego. B358 614.31 Signaling and Secretion of Chemotactic Factors Regulated by Calcium-Sensing-Receptor Mutants Found in Breast Cancer Patients. L.B. Orduña, J.J. Hidalgo-Moyle, J. Vázquez-Prado, G. Reyes-Cruz. CINVESTAV, Mexico. B359 614.32 mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis Through PostTranscriptional Control of ATF4. C.C. Thoreen, Y. Park. Yale School of Medicine. B360 614.33 Encoding the Human Phosphoproteome in an Engineered Bacterial System. K. Barber, J. Rinehart. Yale University. B361 614.34 The Dynamics of an Infrared Light-Activated Adenylyl Cyclase During the Manipulation of Behavior in Caenhorabditis elegans. M. Szurgot, F.M. Janton, M. Nelson. Saint Joseph’s University.

SUNDAY BIOCHEMISTRY B362 614.35 Structure of the Two-Component Response Regulator RcsB-DNA Complex. E.V. Filippova, B. Zemaitaitis, A.J. Wolfe, W.F. Anderson. Northwestern University Feinberg School of Medicine and Loyola University Chicago Stritch School of Medicine. B363 614.36 G Protein-Coupled Estrogen Receptor (GPER)-Mediated Relaxation of Coronary Arteries Is Mitigated by Phosphorylation of ERK1/2 R.C. Harlow, X. Yu, B.P. Kotaki, J.N. Stallone, C.L. Heaps, G. Han. Texas A&M University and Michael E. DeBakey Institute. B364 614.37 Novel Genetic Variants in the Oxytocin Receptor Predict Oxytocin Non-Responsiveness in Pregnant Women. G.Y. Lee, N. Raghuraman, E.L. Reinl, S.K. England. Washington University in St. Louis and Washington University School of Medicine. B365 614.38 Wnt and Ca2+ Signalling Changes in LRRK2 Parkinson’s Disease Models. K. Harvey, A. Wetzel, M. Hughes, T. McKay, S. Waddington, A. Rahim. University College London, United Kingdom and Manchester Metropolitan University, United Kingdom.

615. GROWTH FACTOR AND CYTOKINE SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B366 615.1 Signaling Pathways Involved in TributyltinInduced Increases in Interleukin 6 Production by Lymphocytes. N. Hamza, S. Brown, M. Whalen. Tennessee State University. B367 615.2 Role of MAPKs and NFκB in TributyltinStimulated Interleukin 1 Beta Secretion and Production from Human Immune Cells. M. Boules, S. Brown, M. Whalen. Tennessee State University. B368 615.3 Involvement of MAPK Signaling Pathways in Tributyltin-Induced Increases of Interleukin 1 Beta and Interleukin 6 mRNA in Human Lymphocytes. S.D. Brown, M. Boules, N. Hamza, M. Whalen. Tennessee State University. B369 615.4 Methionine Sulfoximine Reduces Proinflammatory Cytokine Release by Murine Macrophages. T. Peters, A. Jambekar, W. Brusilow. Wayne State University. B370 615.5 A Single EGF Molecule Activates a Preformed EGFR Dimer: A Single-Molecule Multi-Color TIRF Microscopy Study. E. Saita, D. Mong, I.N. Maruyama. OIST, Japan. B371 615.6 Pentabromophenol, a Brominated Flame Retardant Derivate, Suppresses TGF-β Signaling by Sequester TGF-β Receptor from Cell Surface and Further Degradation Through a Caveolae-Mediated Endocytosis. P. Yang, C. Chen. National Sun Yat-sen University, Taiwan.

B372 615.7 Skeletal Muscle-Derived Cytokines Regulate Myogenesis by Modulating Cell Cycle Withdrawal. D. Kim, N. Singh, J. Chen. University of Illinois at Urbana Champaign. B373 615.8 Epidermal Growth Factor Receptor Family Signaling in the Regenerating Axolotl Lung. T.B. Jensen, P. Giunta, N.G. Schultz, H. Wong, J. Monaghan. Northeastern University. B374 615.9 Differential Activation of Class I Phosphoinositide 3-Kinase by Growth Factors. D. Ghosh, S.L. Liu, P. Cho. University of Illinois at Chicago.

616. HORMONE AND NUCLEAR HORMONE SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B375 616.1 A Novel Interaction Between β-Arrestins and Nuclear Steroid Receptors. M.G. Petrillo, J.A. Cidlowski. NIH/NIEHS. B376 616.2 Steroid Hormone Receptor Gene Expression as a Marker for Phenothiazine Induced Endocrine Disruption and Stress in Mummichog, Fundulus heteroclitus. J.M. Laperche, J.B. Chiari, R. Patel, C.L. McGinnis. Quinnipiac University. B377 616.3 Glucocorticoid-Driven Transcriptomes in Airway Epithelial Cell Models: Commonalities, Differences and Functional Insights. M.M. Mostafa, C.F. Rider, R. Newton. University of Calgary, Canada and University of British Columbia, Canada. B378 616.4 Bile Acid Binding Protein STARD5 Suppresses Doxorubicin-Mediated Apoptosis in H1792 Lung Adenocarcinoma Cells. B.J. Clark, S.M. Dougherty, B.G. Hill, C.M. Klinge. University of Louisville School of Medicine. B379 616.5 Endogenous Ligand for Orphan Nuclear Receptor NR2E3 Forms a Light-Sensitive Retinal Transcription System. B. Connor, Y. Lee. Johns Hopkins University. B380 616.6 Examining the Effects of Aldosterone on Putative Target Genes in Mouse Collecting Duct Cells. B. Nolan, K. Solocinski, M.L. Gumz, D. Zies. University of Mary Washington and University of Florida.

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617. PLANT HORMONES AND SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B381 617.1 Unraveling White Lupin’s Signal Transduction in Response to Phosphorus Deficiency Using iTRAQ Labeling, Phosphopeptide Enrichment, and Tandem Mass Spectrometry. M. Amadi, J. Cole, K. Li, R.J. Chalkley, A. Burlingame, C. Uhde-Stone. California State University East Bay, University of California at San Francisco. B382 617.2 Cracking the Interorganellar Communication Codes. A.J. de Souza, J. Svozil, J. Wang, H. Ke, Y. Xiao, W. Gruissem, K. Dehesh. UC Riverside, ETH Zurich, Switzerland and UC Davis. B383 617.3 Expression of E3-Ubiquitin Ligase Genes in P. patens During Sexual Reproduction. E.W. Abrash, K.A. Hicks. Kenyon College. B384 617.4 Identification of a Novel Gene in the Shade Avoidance Response in Plants. N. Wershoven, E. Giddings, A.E. Clark, C. Palmer. Castleton University. B385 617.5 Phosphatidic Acid-Protein Phosphatase 2A Interactions Regulate Haloptropic Bending in Rice. E. Han, D. Petrella, J. Lin, A. DeLong, J.J. Blakeslee. The Ohio State University and Brown University. B386 617.6 Characterizing of the Novel Gene At4g33666 in the Abiotic Stress Response in Arabidopsis. A.E. Miller Clark, N. Wershoven, C. Palmer. Castleton University.

618. EXTRACELLULAR MATRIX AND CELL SIGNALING Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B387 618.1 Thrombomodulin Promotes Cell Adhesion and Migration and Enhances Angiogenesis Through Interaction with Fibronectin. H. Wu, Y. Hsu, G. Shi. National Cheng Kung University, Taiwan. B388 618.2 Biliary Epithelial Cell and Macrophage CrossTalk Is Important to Cyst Progression. M.C. Munteanu, P. Sivasami, B. Ferencz, R.S. Mansat, N. Poudel, T. Watnick, F. Lupu, M. Hinsdale. Oklahoma State University, Oklahoma Medical Research Foundation and University of Maryland School of Medicine.

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B389 618.3 Structural and Functional Insights Into the Latrophilin3-FLRT3-UNC5D Complex That Mediates Glutamatergic Synapse Development. F. Ranaivoson, S. Ozgul, S. Kakehi, V. Jackson, F. Martini, F. Bergami, S. von Daake, E. Seiradake, D. Comoletti. CHINJ, RWJMS, Rutgers University and University of Oxford, United Kingdom. B390 618.4 Controlled BMP2 Release from Keratin-Based Hydrogels Modulates Osteoinduction. L.C. Olson, S.L. Hyzy, J.M. Saul, D.J. Cohen, I. Kajan, Z. Schwartz, B.D. Boyan. Virginia Commonwealth University, Miami University, University of Texas Health Science Center at San Antonio and Georgia Institute of Technology.

619. G PROTEINS AND SMALL GTPASES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B391 619.1 Bioluminescent Assay for GTPases Allows Measurement of GTPase, GAP, and GEF Activities. S. Mondal, K. Hsiao, S. Goueli. Promega Corporation. B392 619.2 Antidepressant Treatment Increases cAMP Signaling by Translocating Gas from Lipid Rafts and Increasing Association with Type 6 Adenylyl Cyclase (AC6) Independent of Action at Monoamine Transporters. J.M. Schappi, M. Rasenick. University of Illinois at Chicago. B393 619.3 DAPLE Links Heterotrimeric G Proteins to Wnt Signaling During Vertebrate Development. A. Marivin, V. DiGiacomo, A. Leyme, M. Garcia-Marcos. Boston University School of Medicine. B394 619.4 Translocation of the Non-Receptor Protein GIV/Girdin to the Plasma Membrane Activates Heterotrimeric G Proteins. A. Leyme, K. Parag-Sharma, V. DiGiacomo, A. Marivin, S. Broselid, M. Garcia-Marcos. Boston University. B395 619.5 Cloning of Novel Leukocytic X5 ARHGEF18 Proteoform for Functional Characterization. H.M. Schira, K.B. Turton, D.S. Annis, D.F. Mosher. Univeristy of Wisconsin-Madison. B396 619.6 Structural and Functional Studies of the Metastatic Factors P-Rex1 and P-Rex2: Toward Small Molecule Inhibitor Development. P. Sharma, E.M. Davis, J. Cash, J.J. Tesmer. University of Michigan. B397 619.7 Cardiovascular Development Defects Produced by Combined Loss of RGS6 and Oxidizable CaMKII Due to Defective Notch Signaling. B. Chakravarti, J. Yang, .​ Ahlers, Z. Luo, H.A. Flaherty, D. Meyerholz, M.E. Anderson, R.A. Fisher. University of Iowa, Iowa State University and Johns Hopkins University School of Medicine. B398 619.8 Structure of a GEM-Complexed Gai Protein Provides Novel Insights Into the Emerging Human GEMiome. I. Kufareva, N. Kalogriopoulos, S.D. Rees, N. Sun, N. Aznar, G. Chang, P. Ghosh. University of California at San Diego.

SUNDAY BIOCHEMISTRY B399 619.9 Dissecting the Roles of ARHGEFs in Eosinophil Polarization. F. Botros, K. Turton, D. Mosher. University of Wisconsin Madison. B400 619.10 Inhibition of Constitutively Active Gsα by Molecules Targeted at R231. M. Schumacher, J. Carroll, S.D. Anderson, P. Santos, Y. Thu, H. Nguyen, K. Bohlen, M. Poch, B.T. Andresen, R.P. Rylaarsdam. Benedictine University and Western University of Health Sciences. B401 619.11 Determinants in the C-Terminal Region of Gα12 and Gα13 Allow Distinct Mechanisms of Cell Growth Signaling. T.L. Fleming, T.E. Meigs. University of North Carolina Asheville. B402 619.12 ER/K Linked GPCR-G Protein Fusions Systematically Modulate Second Messenger Response in Cells. M. Dysthe, R.U. Malik, M. Ritt, R.K. Sunahara, S. Sivaramakrishnan. University of Minnesota, Twin Cities, University of Michigan, University of California at San Diego. B403 619.13 Identification of Endothelial Cell Specific RhoGAPs That Influence TCL Activation and Localization. R.R. Florke, M.J. Hamann. Bemidji State University. B404 619.14 Investigation of TCL/RhoJ Palmitoylation and Its Effects on Cellular Localization. A. Franzen, C. Dague, B. Tader, R.R. Florke, M.J. Hamann. Bemidji State University. B405 619.15 Kinetic Analyses on the Binding of the RhoGEF P-Rex1 by Gβγ and Potential Small Molecule Inhibitors. M. Shost, J. Cash, J. Tesmer. University of Michigan. B406 619.16 The Molecular Mechanisms of Prostaglandin E2 Receptor 3 and Its Associated G Protein, GZ, in the Pancreatic β-Cell. M.D. Schaid, J. Wisinski, E. Laudre, M. Kimple. University of Wisconsin—Madison and University of Wisconsin—Madison. B407 619.17 Finding the Differential Interactome of Active vs Inactive Small Molecular Weight GTPases. T. Peterson, R.C. Piper. University of Iowa. B408 619.18 Determining the Structure of Oncogenic NRas Mutants. M. Ojeda, D. Reid, C. Mattos. Agnes Scott College and Northeastern University. B409 619.19 The C-Terminal Tail of TCL Localizes the GTPase to the Plasma Membrane of HeLa Cells. B. Tader, R.R. Florke, M.J. Hamann. Bemidji State University. B410 619.20 Investigating the Influence of the Rho-Family GTPase TCL/RhoJ on Vesicular Trafficking. T. Olson, S. Taylor, M.J. Hamann. Bemidji State University. B411 619.21 GTP-Loading Activity of TC10/TCL Chimeras Underscores Important Allosteric Regulatory Regions of TCL. G. Young, R.R. Florke, M.J. Hamann. Bemidji State University. B412 619.22 Transition State Mimic of Intrinsic Hydrolysis in Ras GTPase. A.Y. Ortiz. Northeastern University. B413 619.23 The Golgi Arf-GEFs Gea1 and Gea2 Integrate Signals to Coordinate Vesicle Formation. M.A. Gustafson, J. Fromme. Cornell University.

620. MICROBIAL SYSTEMS AND PARASITOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F) Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B414 620.1 Variants in the Toll-Interacting Protein Gene (rs5743899) and Susceptibility to Plasmodium falciparum Malaria Infection in West Africa. I. Farid, R.I. Funwei, S. Agyingi, T. Snyder, C. Falade, O. Ojurongbe, B.N. Thomas. Rochester Institute of Technology and Ladoke Akintola University of Technology, Nigeria. B415 620.2 Functional Characterization of Apically Localized Calmodulins That Regulate Motility and Cell Invasion in Toxoplasma gondii. S. Long. Washington University in St Louis. B416 620.3 Development of an Improved in Vitro Culture System for Cryptosporidium parvum. G. Wilke, L. FunkhouserJones, S. Ravindran, M. Kuhlenschmidt, T. Stappenbeck, L.D. Sibley. Washington University in St. Louis and University of Illinois. B417 620.4 Characterization and Partial Purification of an Inhibitory Factor Secreted by Bacillus anthracis and Aeromonas jandaei. J. McCartney, J. Nesemeier, N. Peterson. North Central College.

621. BACTERIAL COMMUNICATION Poster

S U N

Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B418 621.1 Recognition and Selectivity of Peptide Pheromones by ComR in the Regulation of Natural Competence Among Streptococcus Species. G. Prehna, E. Shanker, D.A. Morrison, A. Talagas, S. Nessler, M.J. Federle. University of Illinois at Chicago and University of Paris-Sud, France. B419 621.2 Construction of a System for the Study of Protein-Induced Membrane Tubules. A. González Rivera, K.T. Forest. University of Wisconsin-Madison. B420 621.3 δ-Lactone Derivatives Induce Quorum Sensing Activity in Agrobacterium tumefaciens D.A. Ewald, A.K. Champion, M.R. Fry. Bradley University.

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622. MICROBE-HOST INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B421 622.1 Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOI. L1 D.A. MacDuff, T.A. Reese, M.T. Baldridge, J.M. Kimmey, L.A. Weiss, C. Song, T.J. Nice, J. Carrero, M. Colonna, B.T. Edelson, D. Sibley, C.L. Stallings, J. Casanova, K. Iwai, S. Virgin. University of Illinois at Chicago, University of Texas—Southwestern, Washington University in St Louis, Oregon Health and Sciences University, The Rockefeller University and Kyoto University, Japan. B422 622.2 Investigation Into a Cell-Density Dependent Pathway in Aerococcus urinae. E.E. Hilt, T.M. Halverson, K.L. Visick, A.J. Wolfe. Loyola University Chicago. B423 622.3 Collagen Mimetic Peptides as Probes for Bacterial Infection. A. Ellison, F. Dempwolff, D. Kearns, R. Raines. University of Wisconsin-Madison and Indiana University. B424 622.4 Metabolic Stress Drives Keratinocyte Defenses Against Staphylococcus aureus Infection. M.A. Wickersham, S. Wachtel, T. Wong Fok Lung, R. Jacquet, G. Soong, A. Richardson, D. Parker, A. Prince. Columbia University and University of Pittsburgh. B425 622.5 RRSP Exhibits Novel Proteolytic Activity. M. Lam, M. Biancucci, K.J. Satchell. Northwestern University and Northwestern University Feinberg School of Medicine. B426 622.6 Probiotic Escherichia coli Nissle 1917 Uses Zinc Transporters and the Siderophore Yersiniabactin to Acquire Zinc in the Inflamed Gut and Outcompete Salmonella typhimurium. J. Behnsen, J. Liu, M. Valeri, E. Hoover, J. Tjokrosurjo, N.P. Montaldo, S. Treacy-Abarca, O. Garibay, B.A. Gilston, R.A. Edwards, W. Chazin, E.P. Skaar, M. Raffatellu. University of California, Irvine, University of Illinois at Chicago, College of Medicine and Vanderbilt University. B427 622.7 Yersiniabactin Is a Recyclable Copper Importer in Pathogenic E. coli. A.E. Robinson, E. Koh, N. Bandara, B.E. Rogers, J.P. Henderson. Washington University. B428 622.8 Investigation of Controlled Expression of MS2 Lysis Protein. K.A. Rasefske, A.J. Piefer. Hartwick College. B429 622.9 Metabolic Immunomodulation of Macrophage Polarization by Pseudomonas aeruginosa Biofilms. M.B. Ammons, A.L. Fuchs, B.P. Tripet, V. Copie. Montana State University. B430 622.10 Relationship of Vpx and APOBEC3A. J. Rachuy, R. Moen, A. Land. Minnesota State University at Mankato. B431 622.11 Effects of Curcumin on Vesicular Stomatitis Virus (VSV) Infection and Dicer-1 Expression. J. Ahmed, Y. Tan, S. Ambegaokar. Ohio Wesleyan University. B432 622.12 A New Link Between Stress and Infection. N. Sule, S. Pasupuleti, N. Kohli, R. Menon, L. Dangott, M. Manson, A. Jayaraman. Texas A&M University and Texas A&M Health Science Center.

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B433 622.13 Isolating and Characterizing Predatory Bacteria from the Built Environment. L.C. Zappia, L.E. Williams. Providence College. B434 622.14 Escherichia coli tRNA Induces Mammalian Cell Migration and Socialization. A.K. Buechler, H. Zhao, D.J. Lieu, S.R. Blanke, S.A. Martinis. University of Illinois at Urbana-Champaign. B435 622.15 Subversion of Host Vesicular Trafficking by Phosphoinositide-Binding Bacterial Proteins. C. Pike, S. Lein, R. Neunuebel. University of Delaware.

623. PLANT-MICROBE INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B436 623.1 Photosynthetic Apparatus and Biochemical Parameters in Tomato and Squash Crops Influenced by Cucumber Mosaic Virus (CMV) Infection. M.S. Montasser, N.Y. Nayef, M. Afzal. University of Kuwait, Kuwait. B437 623.2 Metagenomic Analysis of Bacterial Communities in the Rhizosphere of Leguminous Crops and Trees. C. Ahrenhoerster, G. Prasad, B. Martinez-Vaz. Hamline University and University of Wisconsin- Milwaukee. B438 623.3 Structural Basis for Regulation of Rhizobial Nodulation and Symbiosis Gene Expression by the Regulatory Protein NolR. S. Lee, J. Jez. Washington University in St. Louis. B439 623.4 Chemical and Genetic Analysis of Hopped Meads. J.R. Halmo, M.J. Wolyniak, P.H. Mueller. HampdenSydney College. B440 623.5 Analysis of Bacterial Micro-Biome on Potato Tubers Treated with Sprout Regulator 1,4-Dimethylnaphthalene. R.A. Diaz, R.N. Patel, M.A. Campbell. Penn State Behrend. B441 623.6 Characterization of a Double Deletion Mutant of Fusarium verticillioides Lacking Two Putative Trehalose-6Phosphate Phosphatase Genes. B. McFarlin, E.S. Roberts, E.E. Remsen, C.M. McGovern, D.W. Brown, K.L. McQuade. Bradley University and USDA-ARS-NCAUR. B442 623.7 Isolation of Bio Energy Crop Phyllosphere Bacteria from Switchgrass. M.A. Sleda, K. Grady, K. O’Brien, A. Bennett, A. Shade. Lawrence Technological University and Michigan State University. B443 623.8 Expression and Purification of a Novel Calcium Binding Protein Necessary for Phytopathogenesis in Xanthomonas Strain. K.M. Margin, J.C. Quay, G.V. Minsavage, J.B. Jones, J.C. Hurlbert. Winthrop University and University of Florida. B444 623.9 The Characterization of Septoria lycopersici Pathogenicity in Micro Tom Tomatoes. K.E. Allen, J. ZwieslerVollick. Lawrence Technological University.

SUNDAY BIOCHEMISTRY

624. METABOLISM AND BIOENERGETICS

625. METABOLIC NETWORKS AND REGULATION

Poster

Poster

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:00 pm–2:30 pm

Presentation time: 12:00 pm–2:30 pm

Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm

Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm

B445 624.1 Response of the Energetic Metabolism of Saccharomyces cerevisiae to Different Nutritional Conditions of Carbon and Nitrogen. I.K. Olivares-Marin, L.A. MadrigalPérez, M. Canizal-Garcia, J.C. González-Hernández, C. Regalado-González. Universidad Autónoma de Querétaro, Mexico, Instituto Tecnológico Superior de Ciudad Hidalgo, Mexico and Instituto Tecnológico de Morelia, Mexico. B446 624.2 Cardiac Myocyte KLF5 Regulates Adiposity via Alteration of Cardiac FGF21. C.J. Pol, N.M. Pollak, M.J. Jurczak, I. Karagiannides, P. Ntziachristos, D.A. Scerbo, I. Aifantis, G.I. Shulman, I.J. Goldberg, K. Drosatos. LKSM Temple University, University of Graz, Austria, Yale University School of Medicine, David Geffen School of Medicine at UCLA, NYU School of Medicine, Columbia University and NYULangone School of Medicine. B447 624.3 Decreased Insulin Signaling Causes Loss of PFK-2 and Impaired Glycolysis in the Heart. K. Humphries, L. Bockus, C. Eyster. Oklahoma Medical Research Foundation. B448 624.4 Protein Modifying Enzyme Ate1 Controls Cellular Warburg Effects. C. Jiang, M. Birnbaum, D. Patel, A. Kumar, W. Morgan, T. Lampidis, F. Fontanesi, A. Barrientos, F. Zhang. Miller School of Medicine and University of Miami. B449 624.5 UCP1 Is Essential for Mitochondrial Structural Integrity and Function in Brown Adipose Tissue. C.L. Riley, C. Bean, D. Boutz, S. Kohno, G. Tioli, M. Genova, L. Scorrano, E.L. Mills. University of Texas at Austin, University of Padova, Italy, University of Colorado Denver and University of Bologna, Italy. B450 624.6 Genetic and Functional Characterization of the Enzymes of Nicotinic Acid Degradation in Bacillus niacini. T. To, M.J. Snider. The College of Wooster. B451 624.7 Enhanced Spare Respiratory Capacity in Extremophile Fish Following Exposure to Hydrogen Sulfide. C.R. Henpita, M. Tobler, J.H. Shaw. Oklahoma State University and Kansas State University. B452 624.8 Knockout of p53 Decreases Cardiac Injury by Reducing Ros Generation During Ischemia-Reperfusion. E. Lesnefsky, J. Thompson, Y. Hu, Q. Chen. McGuire VAMC and Pauley Heart Center-VCU.

B453 625.1 Hepatic Fat Accumulation Regulates Carnitine Palmitoyltransferase 1 (Cpt1a) Expression Through Coordinated Epigenetic Mechanisms. L. Moody, P.M. Jung, A. Kriska, H. Chen, Y. Pan. University of Illinois Urbana Champaign. B454 625.2 Administration of Naoxintong to db/db Mice Inhibits the Development of Diabetic Nephropathy. S. Yang, M. Liu, P. Su, J. Han. Nankai University, People’s Republic of China. B455 625.3 The Chemical Biology of Cellular Iron Pools in Prokaryotes. F. Outten, N. Bolaji, J. Wofford, P. Lindahl. University of South Carolina and Texas A&M University. B456 625.4 Gene and Protein Profiling of Effects of Tart Cherry Anthocyanins in Preadipocytes. S.H. Jayarathne, S. Scoggin, K. Claycombe, R. Kottapalli, M. Zabet, R. Bhawal, N. Moustaid-Moussa. Texas Tech University and USDA ARS. B457 626.1 Identifying a Source of Beta-Alanine and Its Broader Implications in Arabidopsis thaliana by GC/MS. M. Perrett, M. Gothard, A. Ludwig, K.A. Rouhier. Kenyon College. B458 626.2 Glutaminase Acts in Osteoblasts to Regulate Bone Formation. C.M. Karner, Y. Yu, J. Tang. Duke University. B459 626.3 Comparison of the Influence of Pre-Exercise BCAA Supplementation on Serum HMB Level Between Endurance and Resistance Exercises. T. Miyazaki, S. Ra, K. Ishikura, H. Ohmori, T. Ikegami, Y. Matsuzaki, A. Honda. Tokyo Medical University Ibaraki Medical Center, Japan, Fukuoka University, Japan, Sojo University, Japan and University of Tsukuba, Japan. B460 626.4 Identification of NADPH-Dependent Glutamate Dehydrogenase in Yarrowia lipolytica. K. Nelson, K. Juco, L. Tamayo, J. Nicaud, P.J. Trotter. Augustana College, INRA and AgroParisTech, France. B461 626.5 Time-Resolved Analysis of Amino Acid Deprivation Responses Reveals Dynamic Relationship Between GCN2 and mTOR. C1. I.A. Nikonorova, M.P. Goudie, E.T. Mirek, Y. Wang, T.G. Anthony. Rutgers, The State University of New Jersey and Center for Health and Human Performance. B462 626.6 Hormonal Regulation of Glycine Metabolism and Its Potential Role in Diabetes Susceptibility. R. Jog, J. Wang, T. Leff. Wayne State University. Kinetic Characterization of B463 626.7 3-Hydroxyisobutyrate Dehydrogenase from Arabidopsis thaliana. C. Binkley, M. McCool, T. Maurer, K.A. Rouhier. Kenyon College. B464 626.8 Cloning and Characterization of Putative Histidinol-Phosphatase Not Called by Machine Annotation. S. Ellis. St. Cloud State University. B465 626.9 Subtle Defects of Four Homocystinuric Variants of Human Cystathionine β-Synthase. J.P. Hines, Y. Su, A.T. Smith, J.N. Burstyn. University of WisconsinMadison, University of Maryland and Baltimore County.

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627. NUCLEOTIDE METABOLISM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B466 627.1 Purine Salvage Drives the Efficacy of an Adenosine Analog Inhibitor of Leishmania RNA Virus 1 (LRV1). J.I. Robinson, F.M. Kuhlmann, S.M. Beverley. Washington University School of Medicine.

628. PLANT METABOLISM AND BIOSYNTHETIC PATHWAYS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B467 628.1 Linking the Cytosolic Phenylalanine Pathway and the Auxin Biosynthetic Pathway. A. Garcia, Y. Qian, J. Lynch, N. Dudareva. Tennessee State University and Purdue University. B468 628.2 Biosynthesis of Granatane Alkaloids in Punica granatum. B.G. Chavez, L. De-Vries, K. Galloway, J. D’Auria. Texas Tech University. B469 628.3 Engineering Biochemical Bypass to Photorespiration to Improve Photosynthesis and Crop Production. P. South, D.R. Ort. USDA-ARS/University of Illinois and USDA-ARS. B470 628.4 Molecular Basis of TyrA Substrate Specificity Underlying the Evolution of Alternative Tyrosine Biosynthetic Pathways. C. Schenck, C. Holland, M. Schneider, J. Jez, H. Maeda. University of Wisconsin-Madison and Washington University in St. Louis. B471 628.5 Does Sensitivity to FACs Result in Higher Resistance Against Herbivory? A. Conner, L. Grisset, J. Stratmann. University of South Carolina. B472 628.6 cDNA Cloning and Characterization of UDPGlucosyltransferase from Indigofera tinctoria. S. Inoue, R. Morita, S.T. Thul, B.K. Sarangi, Y. Minami. Okayama University of Science, Japan and CSIR-NEERI, India. B473 628.7 Tyrosine Biosynthesis Revisited: Characterization of Novel Arogenate Dehydrogenases from Legumes. M.R. Schneider, C.A. Schenck, C.K. Holland, J.M. Jez, H.A. Maeda. University of Wisconsin-Madison and Washington University in St. Louis. B474 628.8 A Study of the Exchangeable Protons in the QA Site of Photosystem II. A. Garmany, Z.D. Runyon, D.S. Kinzer, S. Dikanov, D.R. Kolling. Marshall University and University of Illinois at Urbana—Champaign. B475 628.9 Characterization of Mutant Sunflower Acetoacetyl CoA Thiolase. J. Dyer. Montclair State University.

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B476 628.10 Identifying the Metal That Activates the Prenyltransferase That Catalyzes Formation of Geranyl Diphosphate in the Diatom Pseudo-nitzschia multiseries. H. Tran, T. Savage. California State University Sacramento. B477 628.11 Understanding Plant Energy Sensing and Homeostasis. S. Williams, J. Yen, G. Gillaspy. Virginia Tech. B478 628.12 Inositol Phosphates and Energy Signaling in Plants. O.A. Adepoju, S.P. Williams, G. Gillaspy. Virginia Polytechnic Institute and State University.

629. LIPIDS AND MEMBRANES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B479 629.1 Independent Measurements of Lipids in Mixed Cell Populations. A. Stoeckman, K. Estrada, N. Wolins. Bethel University and Washington University. B480 629.2 Structure of Human Niemann-Pick C1 (NPC1) Protein and NPC1-NPC2 Complex. X. Li. Rockefeller Univeristy. B481 629.3 Monitoring Live Cell Membrane Lipid Encounter Dynamics with DNA Probe. M. You. UMass Amherst. B482 629.4 OlyA—A Tool to Study SphingomyelinCholesterol Interactions in Plasma Membranes. S. Endapally, A. Radhakrishnan. UT Southwestern Medical Center. B483 629.5 Role of Na-H Exchanger-2 in Experimental Colitis: Mechanism of Regulation of Expression. I. Khan, A.A. Soleiman, F. Thameem. Kuwait University, Kuwait, Kuwait and Kuwait University, Kuwait. B484 629.6 Repurposing P-Glycoprotein Inhibitors as Modifiers of Sphingolipid Metabolism—Therapeutic Implications in Cancer. M.C. Cabot. East Carolina University and Brody School of Medicine. B485 629.7 A Common Tale of Substrate Recognition: From Antibiotic Resistance to Neurotransmitter Transport. D. Yaffe, A. Vergara-Jaque, L.R. Forrest, S. Schuldiner. Hebrew University, Israel and National Institutes of Health. B486 629.8 Different Lipids in Synaptic Vesicle and Synaptosome Membrane. K.T. Lewis, K.R. Maddipati, A.R. Naik, B.P. Jena. Wayne State University. B487 629.9 Control of PI4P Turnover by Endogenous OSBP for Fast Cholesterol Transport at Membrane Contact Sites. B. Mesmin, J. Bigay, J. Polidori, S. Lacas-Gervais, B. Antonny. Institut de Pharmacologie Moléculaire et Cellulaire— CNRS, France and Université Nice Sophia Antipolis, France. B488 629.10 Lipoprotein Lipase Regulates the Expression of Genes Responsible for Cellular Cholesterol Uptake and Efflux in Human and Mouse Macrophages. K. Moctar, K.R. Madhwani, A.J. Kim, J.D. Medh. California State University Northridge. B489 629.11 Cardiolipin Content Has a Stronger Influence Than Acyl Chain Composition on Select Membrane Properties of Biomimetic Mitochondrial Membranes. E.R. Pennington, A. Fix, E.M. Sullivan, A. Kennedy, D.A. Brown, T.N. Zeczycki, S.R. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, East Carolina University and Virginia Tech Corporate Research Center.

SUNDAY BIOCHEMISTRY B490 629.12 Lysosome Enlargement in PIKfyve Inhibited Cells Proceeds Through Homotypic Lysosome Fusion Rather Than Growth of Individual Lysosomes. G. Saffi. Ryerson University, Canada. B491 629.13 Characterization of Kinetic Parameters of the Lysophospholipase PldB Using a Liquid Chromatography Mass Spectrometry Based in Vitro Assay. G. Elizalde, T.A. Garrett. Vassar College. B492 629.14 Impact of Altering the Headgroup-Acylated Glycerophospholipid Levels on Escherichia coli Cells Deficient in Phosphatidylserine and Phosphatidylethanolamine. O. Oke, T.A. Garrett. Vassar College. B493 629.15 Styrene-Maleic Acid (SMA) Nanodisc Technology: A Novel Approach for Isolation and Purification of the Infectious Prion Protein (PrPSc) M. Esmaili, X. Wang, B. Tancowny, H. Wille, M. Overduin. University of Alberta, Canada. B494 629.16 Tracking the Flow of Carbon Toward Oil Synthesis in an Emerging Crop Lesquerella (Physaria fendleri). J. Cocuron, E. Tsogtbaatar, A. Alonso. The Ohio State University. B495 629.17 Stereochemical Characterization of AcylPhosphatidylglycerol and bis-(Monoacylglycerol)Phosphate Using Nuclear Magnetic Resonance. C.S. Peros, T.A. Garrett. Vassar College. B496 629.18 Withdrawn. B497 629.19 Modulation of Endothelial Membrane Biomechanics by Oxidized Phospholipids: A Combined Experimental and Computational Approach. M.A. Ayee, E. LeMaster, T. Shentu, N. Barbera, B.S. Akpa, I. Levitan. University of Illinois at Chicago and North Carolina State University. B498 629.20 Probing the Lipid Composition at the Site of Influenza Virus Assembly and Budding with High-Resolution SIMS. M.L. Kraft, A.N. Yeager, P.K. Weber, J. Zimmerberg. University of Illinois at Urbana-Champaign, Lawrence Livermore National Laboratory, National Institute of Child Health and Human Development, National Institutes of Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development. B499 629.21 Phosphorylation of the Glycerol 3-Phosphate Acyltransferase Gpt2 Regulates the Timing of TAG Mobilization upon Growth Resumption. M. Tavassoli, B. Nagler, B. Shabits, A. Lopez-Villalobos, K. Athenstaedt, V. Zaremberg. University of Calgary, Canada, and Institute of Molecular Biosciences, Austria. B500 629.22 Substrate Specificity and Unusual Reaction Mechanism of the Sterol 4-Methyltransferase in Caenorhabdtis elegans. P.M. Fisher, W. Zhou, M.B. Miller, Y. Shen, H. Shi, W.D. Nes. Texas Tech University. B501 629.23 Liver X Receptor (LXR) Activation Decreases Chronic Myelogenous Leukemia Cell Viability and Alters the Expression of Antiapoptotic and Cholesterol Genes. C.J. Andersen, L. Dupree, A. Doerr, L. Cintron-Rivera, K. Murray, N. Ragonesi. Fairfield University. B502 629.24 Ceramide-1-Phosphate: Characterizing a Fluorescent Lipid and Discovering New Binding Proteins. C.M. Shirey, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend.

B503 629.25 Identification of Sphingolipid Metabolism Perturbations in Endothelial Cells Induced by the Acid Sphingomyelinase Inhibitor Imipramine Using Stable Isotope Labeling and Targeted Lipidomics. E. Berdyshev, M.J. Justice, I. Bronova, K.S. Schweitzer, I. Petrache. National Jewish Health. B504 629.26 Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. F.G. Tafesse. Oregon Health & Science University (OHSU). B505 629.27 PKC-δ Mediates Sphk2 Activation and Histone Acetylation in Pseudomonas aeruginosa-Induced Lung Inflammation. D.L. Ebenezer, P. Fu, A.W. Ha, V. Natarajan. University of Illinois at Chicago. B506 629.28 A Prokaryotic-Like Lysophosphatidic Acid Acyltransferase Reveals Unique Features of Triacylglycerol Biosynthesis in Microalgae. Y. Kim, E.L. Terng, W. Riekhof, E.B. Cahoon, H. Cerutti. University of Nebraska-Lincoln. B507 629.29 Study of Resistance to Abyotic Factors Through Oxidative Stress Biomarkers in Kluyveromyces Yeast. B.Vargas Ochoa, J.A. Mejía-Barajas, M. Arellano-Plaza, R. MontoyaPérez, A. Saavedra-Molina. Universidad Michoacana de San Nicolás de Hidalgo, Mexico, Universidad Michoacana de San Nicolás de Hidalgo, Mexico and CIATEJ, Mexico. B508 629.30 Characterizing Lipid Production in Chlorella vulgaris Exposed to Sethoxydim, an Acetyl-CoA Carboxylase Inhibitor. A.L. Smythers, A.T. Holland, A. Roberts, D.R. Kolling. Marshall University.

630. MEMBRANE PROTEINS AND LIPID INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F

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Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B509 630.1 Investigating Phospholipid Binding Residues in the C Terminus of Ebola Virus Matrix Protein, V. P40 M. Budicini, K. Johnson, R.V. Stahelin. University of Notre Dame and Indiana University School of Medicine-South Bend. B510 630.2 Ceramide Induced Regulated Alternative Translocation of TM4SF20 and Beyond. B. Denard, Q. Chen, C. Lee, S. Han, J. Ye, J. Ye. UT Southwestern Medical Center. B511 630.3 Structural Mechanism of Viral Tethering by the Anti-Viral Protein BST-2 K. Ozcan, C. Berndsen. James Madison University. B512 630.4 Small Molecule and Lipid Binding Mechanisms of Sortilin and Vps10 Indicated in Altered Trafficking Patterns and Membrane Fusion. R. Sparks, R.A. Fratti. University of Illinois at Urbana-Champaign. B513 630.5 The Ebola Virus Matrix Protein and Membrane Fluidity. K.A. Johnson, R.V. Stahelin. Notre Dame and IU School of Medicine. B514 630.6 Membrane Localization of Metabolic Enzyme and Metabolic Modulation in the Δmin Mutant of Escherichia coli. Y. Shih, C. Hung, C. Wang. Academia Sinica, Taiwan and National Taiwan University, Taiwan.

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BIOCHEMISTRY SUNDAY B515 630.7 Studying the Effect of Negative Curvature on Amphipathic α-Helix Model Protein Binding to an Oil/ Buffer Interface. M. Mirheydari, E. Mann, E. Kooijman. Kent State University. B516 630.8 Effectiveness of Sub-Therapeutic Staurosporine on Inhibition of Budding and Replication of Lipid-Enveloped Viruses. M. Fraser, R. Stahelin. University of Notre Dame and Indiana University School of Medicine—South Bend. B517 630.9 Hydrophobic Region of Marburg Virus May Indicate Mechanism of Protein Trafficking to Plasma Membrane. K. Wijesinghe, L. McVeigh, R. Stahelin. University of Notre Dame. B518 630.10 Targeting Lipid Metabolism to Inhibit Ebola VP40 Mediated Viral Budding. M.L. Husby, R. Stahelin. University of Notre Dame and Indiana University School of Medicine. B519 630.11 Stronger Together: The Role of Cysteine Residues in Ebola Viral Matrix Protein V. P40. S.B. Baker, K. Johnson, R. Stahelin. University of Notre Dame, Indiana University School of Medicine and South Bend. B520 630.12 Interaction Between a 70-kDa Heat Shock Protein and Phosphatidylserine in Stressed Human Cells. A.D. Bilog, C. Labanieh, N. Nikolaidis. California State University at Fullerton. B521 630.13 Crystal Structure of Lysophosphatidic Acid Acyltransferase Reveals a Paired Reentrant Helix Membrane Anchor That Positions the Active Site Inside the Phospholipid Bilayer. S.W. White, R.M. Robertson, J. Yao, S. Gajewski, G. Kumar, C.O. Rock. St. Jude Children’s Research Hospital. B522 630.14 Binding Interaction of Lipid-Bound ApoA–I with Lipopolysaccharides and Phosphatidylglycerol. B. Haeri, P. Weers. California State University at Long Beach. B523 630.15 Understanding Ethanol Hexanoyl Transferase (Eht1) Localization to Lipid Droplets and the Endoplasmic Reticulum in Saccharomyces cerevisiae. J. Zhu, I. Wheeldon. University of California at Riverside. B524 630.16 Diacylglycerolpyrophosphate and Phosphatidic Acid Related Much? P. Putta, E. Creque, E.E. Kooijman. Kent State University. B525 630.17 Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection. F. Lu, M. Brown, J. Goldstein. University of Texas Southwestern Medical Center. B526 630.18 Phosphatidylinositol 3,5-Bisphosphate Acts as a Novel Regulator of Calcium Transport During Saccharomyces cerevisiae Vacuolar Fusion. G.E. Miner, R.A. Fratti. University of Illinois at Urbana-Champaign. B527 630.19 Organelle-Specific Regulation of V-ATPase Activity by Inositol Phospholipids. P.M. Kane, S. Banerjee. SUNY Upstate Medical University. B528 630.20 Computational Modeling of Human Fatty Acid Transport Protein 2. V.M. Perez, B.L. Puniya, T. Helikar, C.C. DiRusso, P.N. Black. University of Nebraska-Lincoln.

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631. CELL AND ORGANELLE DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B529 631.1 Dissecting Comorbidity Between Parkinson’s Disease and Melanoma in a Cell Culture Model. D. Dele-Oni, A. Bose, G. Petsko. University of Massachusetts Dartmouth and Weill Cornell Medicine. B530 631.2 Stressing Interdisciplinarity to Mold the Undergraduate Experience. C.M. Keller, B.E. Bridges, J.N. Roney, D.R. Dries. Juniata College. B531 631.3 Syntaphilin Regulates Mitochondrial Dynamics and Tumor Cell Invasion. M. Caino, D.C. Altieri. The Wistar Institute.

632. NUCLEAR DYNAMICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B532 632.1 Investigating the Spatiotemporal Distribution Patterns of PCID2 Between the Nucleus and the Centrosome. R.K. Flores, K.K. Resendes. Westminster College. B533 632.2 The Disruption of Nuclear Export and Protein Localization with 5-Fluorouracil. A. Nickle, M. Bischak, K. Higby, K.K. Resendes. Westminster College.

SUNDAY BIOCHEMISTRY

633. ENDOPLASMIC RETICULUM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B534 633.1 The Yeast Homolog of the Mammalian Oncogene, Bax Inhibitor-1, Regulates the Unfolded Protein Response by Altering the ER Microenvironment. S. Benko, D. Eagan, J. Alisch, M. Brown, M. McCarthy, W. Cavedon, J. O’Brien, L. Ritzer, B. Berry, N. Austriaco. Providence College. B535 633.2 Host Control of Gag Localization in a Yeast Retrotransposon System. K.L. McGlone, J.B. Keeney. Juniata College. B536 633.3 Clustering of IRE1α in the Mammalian ER Membrane Is Independent of Its Enzymatic Activities. D. Ricci, I. Marroco, J. Vargas, D. Eletto, M. Dibos, S. Boyle, Y. Iwamoto, Y. Argon. Children’s Hospital of Philadelphia, University of Pennsylvania, Sapienza University of Rome, and University of Salerno. B537 633.4 ER Stress and Molecular Targets of Platinum Anticancer Compounds. R. Cunningham, V. DeRose. University of Oregon.

634. MITOCHONDRIA IN HEALTH AND DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B538 634.1 AMPK Negatively Regulates Mitophagy in the Heart. A. Kaminaris, S. Kobayashi, G. McStay, Q. Liang. New York Institute of Technology College of Osteopathic Medicine. B539 634.2 Effects of Deceased Mitochondrial Ca2+ Uptake in an in Vitro Model of Parkinson’s Disease. N. de la Rosa-González, A. Lee, M. Joiner. University of Puerto Rico at Ponce and University of Iowa.

B540 634.3 Cardiac Mitochondrial Phospholipid Acyl Chains Are Remodeled in Murine Obesity but Do Not Impair Supercomplex Formation, Respiratory Enzyme Activity, or Respiration. E.M. Sullivan, A. Fix, M.J. Crouch, G.C. Sparagna, T.N. Zeczycki, D.A. Brown, S.R. Shaikh. East Carolina University, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, East Carolina University, University of Colorado Denver Anschutz Medical Campus and Virginia Polytechnic Institute. B541 634.4 Functional Insights on the Human Adenine Nucleotide Translocator Interactome. M. Acoba, Y. Lu, S. Kandasamy, T. Huang, R. Nirujogi, A. Pandey, S.M. Claypool. Johns Hopkins University School of Medicine and National Taiwan University Hospital and National Taiwan University Cancer Center, Taiwan. B542 634.5 Overexpression of Manganese Superoxide Dismutase in Mouse Liver Leads to Defects in Oxidative Phosphorylation. S. Steyl. Appalachian State University. B543 634.6 Analysis of Oct1p/MIPEP Proteolytic Processing of Coenzyme Q Biosynthesis Proteins. M.J. Drahnak, M.T. Veling, D.J. Pagliarini. Morgridge Institute for Research and University of Wisconsin-Madison. B544 634.7 Single, Long Molecule PCR for the Detection of Rare Mutations in Mitochondrial DNA. H. Li, S. Annis, D. Woods, J. Tilly, K. Khrapko. Northeastern University. B545 634.8 Fis1 Activity in Pre- and Post-Assembly of the Yeast Mitochondrial Fission Machinery. M.C. Harwig, R.B. Hill. Medical College of Wisconsin. B546 634.9 A Potential Role for Mitochondrial Ca2+ Uptake During B Cell Activation. A. Torres-Quintanilla, E. GonzálezCastillo, G. García-Rivas. Tecnológico de Monterrey, Mexico. B547 634.10 Withdrawn. B548 634.11 Identification of Regulators of Lysosome Formation. G.T. Le, N. Jackson, N. Shaikh, A. Shearon, H. Fares. University of Arizona. B549 634.12 Monitoring Organelle-Specific Responses to Amphotericin B in Mammalian Cells and Candida albicans Biofilms. C. Tourville, G. Rigden, D. Lewis, S. Hartsel. University of Wisconsin-Eau Claire.

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Nutrition 635. BIOAVAILABILITY AND METABOLISM OF CAROTENOIDS AND VITAMIN A Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C1 I 635.1 The Impact of Early Postnatal Vitamin a Supplementation on Childhood Obesity Risk—A Study in Rat Model. C. Wei, A.L. Weaver, C.J. Rogers, A. Ross. The Pennsylvania State University. C2 II 635.2 Carotenoid-Mediated Protection of Human Retinal Pigment Epithelial Cells Against Hypoxic Stress. C. Draper, G.S. Allison, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center. C3 I 635.3 Low Plasma Carotene Concentrations Are Associated with an Increased Risk of Acute Coronary Syndrome in a Korean Population. J. So, M.E. Walker, N.R. Matthan, A.H. Lichtenstein, S.N. Han, I. Chung, E.J. Johnson. Tufts University Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Seoul National University, Republic of Korea, Ewha Womans University, Republic of Korea. C4 II 635.4 Tomato Based Supplement Protects Skin from UV Damage and Photo-Aging Processes. K. Linnewiel Hermoni, G. Raz. Lycored. C5 I 635.5 Retention of Provitamin a Carotenoids in High-Provitamin a Biofortified Maize and Eggs After Various Cooking Methods. M. Sowa, S. Goltz, S.A. Tanumihardjo. University of Wisconsin—Madison. C6 II 635.6 Application of a High-Performance Liquid Chromatography Method for the Evaluation of NonProvitamin A Carotenoids. T.J. Titcomb, C.R. Davis, S.A. Tanumihardjo. UW Madison. C7 I 635.7 Light and Antibiotic Stress Factor in the Accumulation of Carotenoid Pigments in Green Microalgae Isolate. O. Oyebamiji, A. Adeoso. University of Lagos, Nigeria and Yaba College of Technology, Nigeria. C8 II 635.8 Efficacy of Lycopene to Prevent Against Atrazine-Induced Cardiotoxicity via Modulation of Nitric Oxide and Inflammatory NF-κB Pathways. X. Li, J. Lin, L. Qin, J. Xia, S. Zhu, J. Li. Northeast Agricultural University, People’s Republic of China, Qiqihar Medical University, People’s Republic of China. C9 I 635.9 Neuroprotective Effects of Lutein in Neonatal Hypoxic-Ischemic Brain Injury. C.H. Foster, D. Sambalingam, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center. C10 II 635.10 Impact of Acute Dietary Vitamin a Intake on the Measured Variable (Plasma Retinol Specific Activity) Used in Prediction of Total Body Vitamin a Stores by Retinol Isotope Dilution. J.L. Ford, J.B. Green, M.H. Green. Pennsylvania State University. C11 I 635.11 Hepatic Uptake of Vitamin a Is Independent of Retinoic Acid Pretreatment in Neonatal Rats. Y. Li, M.H. Green, L. Tan, A. Ross. The Pennsylvania State University and The University of Alabama.

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C12 II 635.12 A Plasma Proteome Is Associated with Carotenoid Status in Young Nepalese Children. A. Eroglu, K.J. Schulze, R.N. Cole, P. Christian, B.A. Nonyane, S.E. Lee, L.S. Wu, S. Khatry, K.P. West; Jr. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine and John Hopkins Bloomberg School of Public Health. C13 I 635.13 Carotenoids and Apo-Carotenoids in Human Plasma After Continued Consumption of High β-Carotene or High Lycopene Tomato Juice. J.L. Cooperstone, K.M. Riedl, M.J. Cichon, D.M. Francis, R.W. Curley Jr., S.J. Schwartz, J.A. Novotny, E.H. Harrison. The Ohio State University and USDA Beltsville Human Nutrition Research Center. C14 II 635.14 Obesity Leads to Tissue, but Not Serum Vitamin A Deficiency. S.E. Trasino, X. Tang, J. Jessurn, L.J. Gudas. Hunter College and Weill Cornell Medical College. C15 I 635.15 Superior Oral Bioavailability in Beagle Dogs of Lutein Derived from a Novel Manufacturing Process. G.D. Sunvold, K. Brandt, D. Ribera, A. Lazaar, K.J. Wedekind, R. Torras, G. Guirado, J.L. Evans, G. Reznick, G. Castells. Novus International, Novus International, Spain, Isoquimen SL, Spain and Universitat Autonòma de Barcelona, Spain. C16 II 635.16 Bioaccessibility and Intestinal Cell Uptake of Astaxanthin from Salmon and Commercial Supplements. C. Chitchumroonchokchai, M.L. Failla. The Ohio State University. C17 I 635.17 Vitamin A Intake of School-Aged Children Exceed Dietary References Intake in the Western Highlands of Guatemala. M.L. Escobar, M. Vossenaar, N.W. Solomons. CeSSIAM, Guatemala. C18 II 635.18 Uptake and Metabolism of Dietary β-Apocarotenoids by Caco-2 Intestinal Cells. B.O. Durojaye, K.M. Riedl, R.W. Curley, E. Harrison. Ohio State University.

636. NEUROBIOLOGY, MOOD AND BEHAVIOR Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C19 I 636.1 An Open Label Study to Evaluate the Effect of Kaempferia parviflora in Support of Erectile Function and Male Sexual Health Among Overall Healthy Males 50–70. S. Hirsh, L. Huber, R. Stein, K. Schmid, A. Swick, S. Joyal. Life Extension Clinical Research, Inc. and Life Extension. C20 II 636.2 Bipolar Disorder in Youth Is Associated with Increased Low Molecular Weight Fraction of Vitamin D Binding Protein. B. Petrov, A. Aldoori, C. James, K. Yang, G.P. Algorta, A. Samogyi, R. Al Awadhi, E. Arnold, M. Fristad, B. Gracious, O. Ziouzenkova. The Ohio State University, Lancaster University, United Kingdom, Royal College of Surgeons in Ireland, Ireland and Nationwide Children’s Hospital.

SUNDAY NUTRITION C21 I 636.3 A Randomized Double-Blind, Placebo Controlled, Four-Arm Parallel Study Investigating the Effect of a Broad Spectrum Wellness Beverage on Mood State in Healthy, Moderately Stressed Adults. O. Aruoma, M. Evans, J. Anthony, N. Guthrie, B. Landes. University of Long Beach, KGK Synergize Inc, Canada and Nutritional Products Consulting Group. C22 II 636.4 α-Tocotrienol Protects Primary Hippocampal Neurons Against Oxidative Stress-Mediated ΔNBcl-xL Formation in the Mitochondria. H. Park, E.A. Jonas. Yale School of Medicine. C23 I 636.5 12 Weeks of Eating Almonds on Cognitive Function and Cardiometabolic Biomarkers—A Study Protocol. A. Coates, S. Morgillo, C. Yandell, A. Scholey, J. Buckley, A. Hill. University of South Australia, Australia and Swinburne University, Australia. C24 II 636.6 Healthy Profits: An Interdisciplinary Retail Framework for Increasing the Sales of Healthy Foods. B. Wansink. Cornell University. C25 I 636.7 Effects of Hydration on Relational Memory Among Preadolescent Children. D.R. Westfall, K.M. Hassevoort, S. Barnett, A.R. Covello, J.H. Bottin, E.T. Perrier, N.J. Cohen, C.H. Hillman, N.A. Khan. Northeastern University, University of Illinois, Washington State University and Danone Research, France. C26 II 636.8 The Omega-6 to Omega-3 Fatty Acid Ratio Predicts Brain Activity During Planning Tasks in Middle Childhood. K. Sheppard, C.L. Cheatham. The Research Institute at Nationwide Children’s Hospital and University of North Carolina at Chapel Hill. C27 I 636.9 Is It Exercise or a Scenic Walk? Reframing Physical Activity as Fun Leads to Reduced Calorie Compensation, Healthier Meals, and Less Snacking. B. Wansink, C.O. Werle. Cornell University and Grenoble Ecole de Management, France. C28 II 636.10 High Fat Diet Induces Gender-Specific Differential Gene Expression in Drosophila melanogaster Brain. T. Stobdan, P. Azad, E. Heinrichsen, D. Sahoo, I. Hartley, D. Zhou, G.G. Haddad. Univ of California San Diego and Rady Children’s Hospital. C29 I 636.11 The Role of N-Acetylcysteine and 3H-1,2-Dithiole-3-Thione in Maintaining Glutathione Status and Protection Against Advanced Glycation End Product Induced Neurite Degeneration in SH-SY5Y Cells. M.A. Stochelski, T. Wilmanski, J.R. Burgess. Purdue University. C30 II 636.12 Vitamin D Receptor and Megalin Gene Polymorphisms Are Associated with Longitudinal Cognitive Change Among African-American Urban Adults. M.A. Beydoun, S.M. Tajuddin, G.A. Dore, J.A. Canas, H.A. Beydoun, M.K. Evans, A.B. Zonderman. National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Nemours Clinic, Johns Hopkins Medical Institutions and Johns Hopkins University. C31 I 636.13 Dietary Screening Tool Used to Describe Diet Quality in Acquired Brain Injury and Parkinson’s Disease: An Exploratory Study. D.L. LoBuono, L. Hurley, M.J. Delmonico, F. Xu, L. Mahler, I.E. Lofgren. University of Rhode Island.

C32 II 636.14 Effects of Potatoes and Other Carbohydrates Consumed at Breakfast on Cognition, Glycemia and Satiety in Children. J.J. Lee, V.C. Wong, S. Cleary, J. Totosy de Zepetnek, A.J. Fiocco, N. Bellissimo. Ryerson University, Canada. C33 I 636.15 Evaluation of the Association of Toll-Like Receptor 4 and BMI with Postpartum Depressive Symptomatology. B.A. Molkenthin, M.P. Judge, E.E. Young, C.T. Beck. University of Connecticut. C34 II 636.16 Neuroprotective Effect of Rg5/rk1 Against Thermal Stress-Exposed Damage of Hippocampal Cell Line HT-22. S. Choi, J. Song, S. Chei, E. Koh, J. Choi, Y. Seo, M. Park, J. Hwang, Y. Lee, B. Yang, J. Park, B. Lee. CHA University, Republic of Korea, Chung-Ang University, Republic of Korea, Korean Ginseng Research Co., Ltd., Republic of Korea. C35 I 636.17 Neuroprotective Effect of Spirulina Maxima Extract Against Trimethyltin-Induced Neuronal Damage in HT-22 Cells. s. Chei, E. Koh, Y. Seo, J. Choi, Y. Lee, J. Hwang, J. Song, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea. C36 II 636.18 Spirulina maxima Extract Protects Against TMT-Induced Cognitive Disorder in SH-SY5Y Cells. S. Chei, Y. Seo, E. Koh, J. choi, J. Hwang, Y. lee, J. Song, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea. C37 I 636.19 Modulation of Protein Status in Humans Leads to Preference for Increased Portions. O. Davidenko, S. Fromentin, P. Barbillon, G. Fromentin, D. Tomé, N. Darcel. UMR 914 Physiology of Nutrition and Ingestibe Behavior— AgroParisTech, INRA, Paris-Saclay, France, UMR MIA and INRA AgroParisTech Universite? Paris-Saclay, France. C38 II 636.20 Consumption of a 4-Week, Carbohydrate-Restricted Diet Improves Food Intake Motivation in Overweight Subjects. N.T. Le, Q. Hu, M.M. Syed Abdul, C. Heimowitz, E.J. Parks. University of Missouri and Atkins Nutritionals. C39 I 636.21 Adequate Hydration and Sleep Support Pre-Test Cognitive Performance in College Students. B. Beezhold, C. Radnitz, J. Dalrymple, A. Feldman, L. Todd, F. Fatima, C. Filbin, R. Fritz, E. Gerlach, P. Gulling, E. Walker. Benedictine University and Fairleigh Dickinson University. C40 II 636.22 Early Life Diet Alters Sleep Architecture Following an Acute Stress: The Potential Role of Milk Oligosaccharides. M. Chichlowski, S. Morairty, B.M. Berg. Mead Johnson Pediatric Nutrition Institute and SRI International. C41 I 636.23 Is Chocolate Beneficial for Brain Health? Dark Chocolate (70% Cacao) Increases Brain EEG Power Spectral Density (μV2) Gamma Wave Frequency (31–40 Hz), Which Is Associated with Enhanced Cognitive Processing, Learning, Memory, Recall, Neural Synchrony and Mindfulness Meditation. L. Berk, E. Lohman, G. Bains, K. Bruhjell, J. Bradburn, N. Vijayan, S. More. Loma Linda University.

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NUTRITION SUNDAY C42 II 636.24 Nuts and Brain Health: Nuts Increase EEG Power Spectral Density (μV²) for Delta Frequency (1–3 Hz) and Gamma Frequency (31–40 Hz) Associated with Deep Meditation, Empathy, Healing, as Well as Neural Synchronization, Enhanced Cognitive Processing, Recall, and Memory All Beneficial for Brain Health. L. Berk, E. Lohman, G. Bains, K. Bruhjell, J. Bradburn, N. Vijayan, S. More, K. Patel, S. Dhuri, S. Mourya, G. Park, A. Gujaran, S. Nikam. Loma Linda University. C43 I 636.25 1,25(OH)2D3 Protects SH-SY5Y Human Neuroblastoma Through Decreasing Aβ Toxicity and Reducing Tau Protein Hyperphosphorylation. H. Liao, Y. Chang, S. Lin. School of Nutrition and Health Sciences, Taipei Medical University, Taiwan and School of Nutrition and Health Sciences, Taiwan. C44 II 636.26 A Possible Emerging Role of Stachys siedlbodii MIQ Extract in Neuroprotection: In Vitro and in Vivo V.A. Ravichandran, M. Kim, Y. Cha. Chonbuk National University, Republic of Korea. C45 I 636.27 Migraine as a Metabolic Disease. A.A. Stanton. independent researcher. C46 II 636.28 Relationship Between Whole Grain Consumption and Selective Attention. J. Evensen, C. Edwards, S. Thompson, H. Holscher, N. Khan. University of Illinois at Urbana Champaign. C47 I 636.29 Seedy Business: Adding Healthy Additives Transforms Indulgence to Health Food in Consumers’ Minds. A. Tal, B. Wansink. Cornell University. C48 II 636.30 Why Kids Should Play with Their Phone During Dinner: Active Engagement Can Decrease Food Consumption. A. Tal, B. Wansink. Cornell University. C49 I 636.31 Serve Yourself from Overeating: PreServed Portions Lead to Uniform Eating Across Distraction Levels. A. Tal, B. Wansink. Cornell University. C50 II 636.32 More of a Bad Thing: How Consumers Ignore Pollutant Levels. A. Tal, B. Wansink. Cornell University. C51 I 636.33 Limited Access to a Palatable High Fat Diet Promotes Binge-Like Food Intake and Addiction-Like Dopamine Terminal Adaptations in the Nucleus Accumbens Core of Mice. S. Fordahl, S. Jones. Wake Forest School of Medicine and University of North Carolina at Greensboro. C52 II 636.34 Sustained Exposure to High-Sucrose Diet Triggers Endoplasmic Reticulum Stress in Hippocampus and Anticipates Cognitive and Motor Impairments in Adults Rats. B.A. Pinto, T.M. Melo, K.F. Flister, L.M. França, D. Kajihara, V.R. Moreira, S.R. Pereira, F.R. Laurindo, A.M. Paes. UFMA, Brazil and Heart Institute of the School of Medicine, Brazil. C53 I 636.35 Relationship Between Polyphenol Consumption and Physical Activity and Sleep. S. Grobe, J. teRiele, R. Martin, A. Boolani. Clarkson University. C54 II 636.36 Dietary Fatty Acids and Associated with Anxiety and Depression in Older Adults. J. Luo, S.C. Chai, B.H. Arjmandi. University of Delaware and Florida State University. C55 I 636.37 A Ketogenic Diet Prevents Abnormal Changes in Peripheral Nerve Function Caused by a High-Fat Diet. M. Cooper, J. Ryals, D. Wright. University of Kansas Medical Center.

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C56 II 636.38 Serum Endocannabinoids in the Luteal Phase of the Menstrual Cycle Are Associated with Leptin and Food Cravings. S. Krishnan, K. Agrawal, R.R. Tryon, L.C. Welch, W.F. Horn, J.W. Newman, N.L. Keim. University of California, Davis and USDA-WHNRC. C57 I 636.39 Acute Effects of Wild Blueberry Intake on Metabolic Markers and Cognitive Performance in MiddleAged Adults. S. Rahman, A. Whyte, Y. Huang, C. Williams, R. Krikorian, B. Burton-Freeman. Illinois Institute of Technology, University of Reading, United Kingdom and University of Cincinnati Academic Health Center. C58 II 636.40 Intake of Nutrients Among Individuals at Risk for Suicide Enrolled in the Better Resiliency Among Veterans and Non-Veterans with Omega-3’s (BRAVO) Clinical Trial. K.B. Johnson, B.P. Marriott, J.C. Newman, B. Team. Medical University of South Carolina. C59 I 636.41 Relationship Between Severity of Depression and Alcohol and/or Tobacco Use Among Adults with Type 2 Diabetes. N. Shaikh, S. Poongothai, M. Ali, L. Chwastiak, V. Mohan. National Institutes of Health, Madras Diabetes Research Foundation, India, Emory University and University of Washington.

637. TRACE ELEMENT TRANSPORT AND HOMEOSTASIS IN HEALTH AND DISEASE Poster (Sponsored by: Vitamins and Minerals RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C60 I 637.1 Increasing Dietary Iron Intake Perturbs Copper Metabolism in a Dose-Dependent Fashion in Growing Sprague-Dawley Rats. J. Ha, C. Doguer, S.R. Flores, T. Wang, S. Jeong, J.F. Collins. University of Florida. C61 II 637.2 Prolonged High Altitude Exposure Results in Elevated Erythroferrone and Diminished Hepcidin Levels in Healthy Young Male Volunteers. J.P. McClung, S.R. Hennigar, C.E. Berryman, A.J. Young, S.M. Pasiakos. US Army Research Institute of Environmental Medicine. C62 I 637.3 Copper-Induced Reversal of Fibrosis in Rat Model of Cardiac Hypertrophy Is Associated with Enhanced Collagen Degradation by MMP-2 Up-Regulation. Y. Liu, Y. Xiao, J. Liu, P. Han, L. Feng, Y. Kang. Regenerative Medicine Research Center, West China Hospital, Sichuan University, People’s Republic of China, and University of Louisville School of Medicine. C63 II 637.4 The Loss of Copper and the Increase in COMMD-1 in Ischemic Hearts of Mice. K. Li, C. Li, S. Hu, C. Fu, Y. Kang. Regenerative Medicine Research Center West China Hospital Sichuan University, People’s Republic of China, Department of Pharmacology and Toxicology and University of Louisville. C64 I 637.5 Regression of Pressure OverloadInduced Cardiac Hypertrophy by Trientine-Induced Copper Redistribution to the Heart in Rats. J. Liu, Y. Liu, C. Fu, Y. Xiao, Q. Feng, S. Fan, X. Ding, L. Qiu, P. Han, Y. Kang. Sichuan University, People’s Republic of China, and University of Louisville School of Medicine.

SUNDAY NUTRITION C65 II 637.6 Characterization of a Hepcidin Knockout Rat, a Novel Model of Iron Overload. S.R. Flores, X. Wang, J. Ha, C. Doguer, T. Wang, J.F. Collins. University of Florida. C66 I 637.7 Lack of Intestinal Divalent Metal-Ion Transporter 1 (DMT1) Impairs Copper Absorption in Female Mice. X. Wang, S.R. Flores, J. Ha, C. Doguer, T. Wang, J. Collins. University of Florida. C67 II 637.8 Loss of ZIP12 Leads to Mitochondrial Dysfunction and Reduced Neurite Outgrowth in Neuro-2A Neuroblastoma Cells. T.Z. Tang, M.D. Hart, M.R. Nacke, L. Wu, J.L. Fiddler, S.L. Clarke, B.J. Smith, D. Lin, W. Chowanadisai. Oklahoma State University. C68 I 637.9 Zinc and Copper in Oral Submucous Fibrosis. P.K. Sachdev, J. Freeland-Graves, N.S. Beretvas, N. Sanjeevi. The University of Texas at Austin. C69 II 637.10 Quantifying the Association Between Acute Leukemia and Serum Zinc, Copper, and Selenium. S. Kim, M. Babaei, P.K. Sachdev, N. Beretvas, J.H. FreelandGraves. The University of Texas at Austin. C70 I 637.11 Hepcidin-Dependent Iron Mobilization Is Required for White to Beige Adipocyte Conversion. J. Kim, G. Ozaki, M. Okla, J. Lee, S. Chung. University of Nebraska Lincoln.

638. MICRONUTRIENT INTERVENTIONS

C72 II 638.2 Nature of the Proposed AntiHyperglycemic Chromium(III) Malate. J.B. Vincent, M. Smart, H. Tannehill, S. Brown. The University of Alabama. C73 I 638.3 Micro-Nutrient Supplementation Affects Mood Depending on Dopamine and Serotonin Single Nucleotide Polymorphisms Associated with Psychiatric Symptoms. D. Benton, S. Long, H.A. Young. Swansea University, United Kingdom and Cardiff University, United Kingdom. C74 II 638.4 Differential Effects of 1,25D3-MARRS Expression on Mammary Gland Growth and Development Depend on the Vitamin D3 Dose. A. Wilkin, T. Trinh, M. Edson, K. Meckling. University of Guelph, Canada. C75 I 638.5 Efficacy of Various Vitamin D Correction Strategies in Saudi Adults and Children. N. Al-Daghri, S. AbdAlrahman, Y. Al-Saleh, N. Aljohani, O. Al-Attas, M. Alokail. King Saud University, Saudi Arabia, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia and King Fahad Medical City, Saudi Arabia. C76 II 638.6 Improvement in Fatigue, Quality of Life and Cognitive Function Following Oral Iron Supplementation for Treatment of Iron Deficiency in Patients Who Have Had Bariatric Surgery. N. Gletsu Miller, R.A. Mischler, S.M. Armah, T. Redick, A.D. Rosen, J.N. Choi. Purdue University, University of North Carolina at Greensboro and Indiana University.

639. GLOBAL NUTRITION I

Poster (Sponsored by: Vitamins and Minerals RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C71 I 638.1 Modifiers of the Effect of Maternal Multiple Micronutrient Supplementation: An Individual Patient Data MetaAnalysis of 17 Randomized Trials. E.R. Smith, A. Shankar, L. Wu, S. Aboud, S. Adu-Afarwuah, H. Ali, M. Apriatni, S. Arifeen, P. Ashorn, Z.A. Bhutta, P. Christian, D. Devakumar, K.G. Dewey, H. Friis, E. Gomo, P. Gupta, P. Kæstel, P. Kolsteren, H. Lanou, K. Maleta, A. Mamadoultaibou, G. Msamanga, D. Osrin, L. Persson, U. Ramakrishnan, J.A. Rivera, A. Rizvi, H. Sachdev, W. Urassa, K.P. West, N. Zagre, L. Zeng, W. Fawzi, C. Sudfeld. Boston Children’s Hospital, Harvard T.H. Chan School of Public Health, Johns Hopkins Bloomberg School of Public Health, Muhimbili University of Health and Allied Sciences, Tanzania, University of Ghana, Legon, Ghana, Johns Hopkins University in Bangladesh, Bangladesh, SUMMIT Institute of Development, Indonesia, ICDDR,, Bangladesh, University of Tampere School of Medicine, Finland, The Aga Khan University, Pakistan, Hospital for Sick Children, Canada, UCL Institute for Global Health, United Kingdom, University of California-Davis, University of Copenhagen, Denmark, University of Zimbabwe, Zimbabwe, University College of Medical Sciences, India, Prince Leopold Institute of Tropical Medicine, Belgium, Institut de Recherche en Sciences de la Santé, Burkina Faso, School of Public Health and Family Medicine, University of Malawi College of Medicine, Malawi, Food and Agriculture Organization of the United Nations, Gabon, Uppsala University, Sweden, Rollins School of Public Health, Emory University, Instituto Nacional de Salud Publica, Mexico, Sitaram Bhartia Institute of Science and Research, India, UNICEF Regional Office for West and Central Africa, Senegal, Xi’an Jiaotong University College of Medicine, and People’s Republic of China.

Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C77 I 639.1 Body-Segment Profile in MidLife Women Residents in Quetzaltenango, Guatemala: A Perspective on Stunting in Adulthood. M. Gopal, M. Escobar, R. García-Meza, N.W. Solomons, O.I. Bermudez. Center for Studies of Sensory Impairment, Aging and Metabolism (CeSSIAM), Guatemala, Department of Public Health and Community Medicine and Tufts University School of Medicine. C78 II 639.2 Nutritional Status and Stunting Among Pre-School Children in Bhutan: FIndings of the 2015 National Nutrition Survey. Y. Kang, R.K. Campbell, K.P. West. Johns Hopkins School of Public Health. C79 I 639.3 The Impact of Nutritional Interventions on Linear Growth After 2 y of Life: A Systematic Review and Meta-Analysis of Controlled Trials. J.L. Roberts, A.D. Stein. Emory University. C80 II 639.4 Infant Nutritional Status and Markers of Environmental Enteric Dysfunction Are Associated with MidChildhood Anthropometry and Blood Pressure in Tanzania. L.M. Locks, R.S. Mwiru, E. Mtisi, K.P. Manji, C.M. McDonald, E. Liu, R. Kupka, R. Kisenge, S. Aboud, K. Gosselin, M.W. Gillman, A.T. Gewirtz, W.W. Fawzi, C.P. Duggan. Harvard TH Chan School of Public Health, Management and Development for Health, Tanzania, African Academy for Public Health, Tanzania, Muhimbili University of Health and Allied Sciences, Tanzania, Boston Children’s Hospital, United Nations Children’s Fund (UNICEF), Harvard Medical School and Georgia State University.

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NUTRITION SUNDAY C81 I 639.5 Consumption of Fortified Infant Foods Reduces Dietary Diversity But Has a Positive Effect on Subsequent Growth in Indonesian Infants. A. Diana, S.R. Mallard, J. Hazard, D.M. Purnamasari, I. Nurulazmi, P.D. Herliani, G.I. Nugraha, R.S. Gibson, L. Houghton. Universitas Padjadjaran, West Java, Indonesia and University of Otago, New Zealand. C82 II 639.6 Implications of Growth Model Selection on the Associations of Fetal and Infant Growth with Later Childhood Outcomes. A. Krishna, M. Leung, S. Yang, D. Bassani, D. Roth. The Hospital for Sick Children, Canada and McGill University, Canada. C83 I 639.7 Trunk-To-Leg Ratio in Regions of Extreme Stunting Prevalence in the Western Highlands of Guatemala: A Comparative Perspective and Interpretation. K. Shiu, J. Beintema, W.M. Liem, R. García-Meza, C. Doak, M. Orozco, N.W. Solomons. CeSSIAM, Guatemala. C84 II 639.8 Maternal Perceptions of Children’s Linear Growth in Bangladesh: Perspectives from Urban and Rural Caregivers of Diverse Parenting Experience. S.B. Ickes, M. Hossain, L. Rice, N. Naila, B. Nahar, D. Denno, T. Ahmed, J. Walson. University of Washington, International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Bangladesh. C85 I 639.9 A Novel Distribution Method to Provide Micronutrients at a Community Level Improves Linear Growth in Young Guatemalan Children. L.M. Villanueva, A.M. Palacios. The Mathile Institute. C86 II 639.10 Low Birth Weight Is More Common in Food Insecure Pregnant Malawian Women with Moderate Malnutrition. S. Quon, P. Papathakis, A. Schaffner, E. Finfer, L. Bell, B. Peace, M. Varni, E. Gates, C. Tolleshaug, M. Manary. California Polytechnic State University and Washington University School of Medicine. C87 I 639.11 Provision of Supplementary Food to Pregnant Malawian Women with Moderate Acute Malnutrition Improves Gestational Weight Gain and Reduces Low Birth Weight. P. Papathakis, A. Schaffner, P. Garcia, R. Eckert, J. Fry, S. Malek, I. Trehan, C. Thakwalakwa, K. Maleta, M. Manary. California Polytechnic State University, Washington University School of Medicine and University of Malawi, Malawi. C88 II 639.12 Metrics of Early Childhood Growth in Recent Human Growth Research: A Scoping Review. M. Leung, N. Perumal, E. Mesfin, A. Krishna, S. Yang, W. Johnson, D. Bassani, D. Roth. The Hospital for Sick Children, Canada, McGill University, Canada and Loughborough University, United Kingdom. C89 I 639.13 Association of Novel Complementary Feeding Indicators with Length-For-Age Z-Scores in Rural Malawi. E.C. Faerber, J. Ko, J. Weiss, A. Webb Girard. Emory University and Concern Worldwide, Malawi. C90 II 639.14 Maternal Factors Contribute to Low Cranial Size Among Mam-Mayan Infants in Guatemala. H.M. Wren, N.W. Solomons, M.E. Scott, K.G. Koski. McGill University, Canada, CeSSIAM, Guatemala and Center for Host-Parasite Interactions, Canada. C91 I 639.15 Infant and Young Child Feeding (IYCF) Indicators in Madagascar: Analysis of the Demographic and Health Survey. H. Rakotomanana, G. Gates, D. Hildebrand, B.J. Stoecker. Oklahoma State University.

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C92 II 639.16 Multiple Low-Level Metal Exposure and Indicators of Weight and Height in Uruguayan Urban School Children. C.M. Donangelo, E.I. Queirolo, N. Mañay, F. Peregalli, K. Kordas. Universidad de la Republica del Uruguay, Uruguay, Universidad Católica del Uruguay, Uruguay, Catholic University of Uruguay, Uruguay and University at Buffalo. C93 I 639.17 A Multi-Level Risk Factor Assessment for Stunting: Evidence from a National Sample in Nepal. J. Dorsey, S. Manohar, S. Neupane, B. Shrestha, A. ThorneLyman, P. Webb, R.D. Klemm, K.P. West Jr. Johns Hopkins Bloomberg School of Public Health, Nutrition Innovation Lab— Nepal, Nepal, Harvard TC Chan School of Public Health, Tufts University and Helen Keller International. C94 II 639.18 Early Childhood Linear Growth Faltering in Low- And Middle-Income Countries Is a Whole-Population Condition: Implications for Identifying the Causes of Stunting. D.E. Roth, A. Krishna, M. Leung, J. Shi, D. Bassani, I.C. da Silva, A. Barros. Hospital for Sick Children, Canada, Harvard T.H. Chan School of Public Health and Universidade Federal de Pelotas, Brazil. C95 I 639.19 Seasonal Differences in Birth Weights and Lengths Depend on Exposure During Pregnancy in Rural India. E.M. Madan, J.D. Haas, P. Menon, V. Kumar, A. Kumar, S. Singh, S. Dixit. Cornell University, International Food Policy Research Institute, India and Community Empowerment Lab, India. C96 II 639.20 Nutritional Resilience Following the 2015 Earthquake in Nepal. A.L. Thorne-Lyman, S. Manohar, B. Shrestha, S. Neupane, B. Nonyane, S. Shrestha, P. Webb, R.D W. Klemm, K.P. West Jr. Johns Hopkins Bloomberg School of Public Health, Harvard T.H. Chan School of Public Health, PoSHAN Study Team, Nepal, Tufts University Friedman School of Nutrition Science and Policy and Helen Keller International. C97 I 639.21 Secular Trends in Adult and Adolescent Maternal Nutritional Status and Birth Size from 2008–2012 in Rural Bangladesh. M. Na, A.A. Shamim, A.L. Labrique, H. Ali, L.S-F. Wu, S. Shaikh, R.D. Klemm, P. Christine, K.P. West. University of California Davis, FHI 360, Bangladesh, Johns Hopkins Bloomberg School of Public Health, JiVitA Project of Johns Hopkins University, Bangladesh, Helen Keller International and Bill & Melinda Gates Foundation. C98 II 639.22 Women’s Empowerment, Household Dietary Intake, and Individual Dietary Intakes in Urban Bangladesh: Repeated Cross-Sectional Study. S.S. Sinharoy, J. Waid, M. Ali, K.M. Yount, S.H. Thilsted, A. Webb-Girard. Emory University, Helen Keller International, Bangladesh and WorldFish, Cambodia. C99 I 639.23 Creating Healthy Food Interventions in Food Pantries: First and Separately Seen Is Selected. B. Wansink, H. Bhana. Cornell University and Columbia University. C100 II 639.24 Genome-Nutrition Divergence: Evolving Understandings of the Malnutrition Spectrum. J. Eaton, L. Iannotti. Washington University in St. Louis. C101 I 639.25 Quantification and Validation of a SemiStructured 24-Hour Diet Recall for Infants and Young Children in Rural Bangladesh. Z.T. Chowdhury, K. Hurley, R.K. Campbell, S. Shaikh, A. Shamim, S. Mehra, P. Christian. Johns Hopkins Bloomberg School of Public Health, JiVitA Project, Bangladesh, FHI360, Bangladesh and Bill & Melinda Gates Foundation.

SUNDAY NUTRITION C102 II 639.26 A Cross-Sectional Study in Rural Areas of Myanmar: The Impacts of Dietary Behaviors and Nutrition Intervention on 6- to 72-Month-Old Children. A. Zhao, H. Gao, N. Win, Y. Zhang. Peking University, People’s Republic of China, and Health Poverty Action Eastern Asia Programme Office, Myanmar. C103 I 639.27 Micro-Farming of Palm Weevil Larvae (Akokono) for Economic Empowerment and Nutritional Impact. M. Parker, S. Zobrist, C. Tawiah, G. Manu, K. Mansen, S. Soor, A. Laar, K. Kreis. PATH, Kintampo Health Research Centre, Ghana, Seattle Children’s Hospital, Aspire Food Group and University of Ghana, Ghana. C104 II 639.28 Dietary Protein Inadequacy Among Women of Reproductive Age from Five Low-Income Countries. J.E. Arsenault, K.H. Brown. University of California, Davis and Bill & Melinda Gates Foundation. C105 I 639.29 Assessing the Impact of Livestock Husbandry on Anemia in Women and Children: A Systematic Review. N.J. Lambrecht, A.D. Jones. University of Michigan. C106 II 639.30 Food Group Intake Differs Among Adult Food Secure, Low Food Secure and Very Low Food Secure Rural, Midwestern Emergency Food Pantry Users. B.N. Wright, L.A. McCormack, S. Stluka, D. Contreras, L. FranzenCastle, B. Henne, D. Mehrle, D. Remley, H.A. Eicher-Miller. Purdue University, South Dakota State University, Michigan State University, University of Nebraska-Lincoln, University of Missouri and Ohio State University. C107 I 639.31 The Association Between Animal Source Foods and Stunting in Children Aged 6 Months to 5 Years: A Systematic Review. M.J. Shapiro, S. Downs, D. Quelhas, K. Kreis, K. Kraemer, J. Fanzo. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, PATH and Sight and Life, Switzerland. C108 II 639.32 Cooking Time and Iron Bioavailability: The USDA-ARS Approach to Bean Fe Biofortification. R. Glahn, K. Cichy, E. Tako, J. Wiesinger. USDA-ARS. C109 I 639.33 A Grandmother-Inclusive Approach to Community Nutrition Positively Impacted Maternal Nutrition and Health Seeking Practices in Southern Sierra Leone. A.W. Girard, R. Wee, J. Simba, C. Gruenewald, J. Aubel, C. MacDonald, A.S. Bangura, B. Aidam. Emory University, World Vision, Sierra Leone, Sierra Leone, World Vision Germany, Germany, The Grandmother Project—Change Through Culture, Italy, World Vision Canada and Nutrition Centre of Expertise, Canada. C110 II 639.34 A Grandmother-Inclusive Approach to Community Nutrition Education Improves Infant and Young Child Feeding Outcomes in Southern Sierra Leone. R. Wee, J. Simba, B. Aidam, C. Gruenewald, J. Aubel, C. MacDonald, A.S. Bangura, A. Webb Girard. Rollins School of Public Health, Emory University, World Vision, Sierra Leone, Sierra Leone, World Vision Canada, Nutrition Centre of Expertise, Canada, World Vision Germany, Germany and The Grandmother Project—Change Through Culture, Italy. C111 I 639.35 Food Insecurity, Food Coping Strategies, and Child Health Among Ghanaians and Long Term Liberian Refugees Living in Ghana. A. Hromi-Fiedler, A. Lartey, D. Gallego-Perez, A. Sandow, R. Perez-Escamilla. Yale University, University of Ghana, Ghana, Boston University and Buduburam Nutrition Program, Ghana.

C112 II 639.36 Nutrient Analysis of Farmed Palm Weevil Larvae for the Advancement of Edible Insects in Ghana. M. Parker, S. Zobrist, K. Mansen, S. Soor, A. Laar, C. Asiedu, H. Lutterodt. PATH, Seattle Children’s Hospital, Aspire Food Group, University of Ghana, Ghana and Kwame Nkrumah University of Science and Technology, Ghana. C113 I 639.37 Ethnicity and Socioeconomic Factors Are Associated with Poor Nutritional Status in Female Tea Plantation Workers from Rural India. S. Venkatramanan, G.S. Marquis, J.D. Haas. McGill University, Canada and Cornell University. C114 II 639.38 Infant and Young Child Feeding (IYCF) Practices and Nutritional Status Under 2 Years of Age in Bhutan. R.K. Campbell, Y. Kang, K.P. West; Jr. Johns Hopkins Bloomberg School of Public Health. C115 I 639.39 Inadequate Zinc and Calcium But Adequate Iron Intakes in Lactating Women from Southern Ethiopia. M. Girma, H. Seid, B. Tilahun, B.J. Stoecker. Oklahoma State University and Hawassa University, Ethiopia. C116 II 639.40 The Manteca Yellow Bean: A Genetic Resource of Fast Cooking and High Iron Bioavailability Phenotypes for the Next Generation of Andean Dry Beans (Phaseolus vulgaris L.) J. Wiesinger, K. Cichy, E. Tako, J. Hart, R. Glahn. USDA-ARS. C117 I 639.41 Cross Sectional Survey of Pregnant Adolescent Malnutrition in Rural Malawi. C. Patella, C. Thakwalakwa, B.J. Stoecker. Oklahoma State University and University of Malawi, Malawi. C118 II 639.42 Exploring Aflatoxin Prevention and Control Practices in Banke, Nepal. J.Y. Andrews Trevino, S. Ghosh, B. Rogers, G. Shively, D. Davis, K.P. Baral, P. Webb. Tufts University, Purdue University, Helen Keller International, Nepal and Patan Academy of Health Sciences, Nepal. C119 I 639.43 El Niño Southern Oscillation Affects Girls’ Nutrient Intakes and Adequacies in the Peruvian Amazon. R. Ambikapathi, M. Kosek, P. Yori, M. Paredes Olortegui, B. Zaitchik, G.O. Lee, A. Bauck, L. Caulfield. Johns Hopkins Bloomberg School of Public Health, Biomedical Investigations Unit AB PRISMA, Iquitos Peru., Peru, Johns Hopkins University and University of Michigan. C50 I 957.21 United States Department of Agriculture (USDA) MyPlate-Based Nutrition Education Program Increases Adolescent Female Athlete Intention to Consume More Fruits and Vegetables. K. Sarigiannis, M. Hudson, V. Uhley. Oakland University William Beaumont School of Medicine and Avondale School District. C121 I 639.45 Socio-Demographic, Clinical and Behavioral Characteristics of Brazilian Dyslipidemic Adults Enrolled in a Lifestyle Modification Program. H.T. Kano, G.N. Vilches, L.P. Barros, O. Teixeira, R.M. Manda, R.C. Burini. UNESP Medical School, Brazil. C122 II 639.46 The Non-Caloric Sweeteners Aspartame, Sucralose and Stevia sp. Induce Specific but Differential Responses to Compartmentalized Adipose Tissue Accumulation. F.B. Pliego-Rivero, B.C. Sosa-García, G.B. Otero, R.B. Oros-Pantoja. UAEMEX-MEDICINA, Mexico.

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NUTRITION SUNDAY C123 I 639.47 Effectiveness of a 10-wk Lifestyle Modification Program in Reducing Hypertension in Brazilian Free-Living Adults. R.C. Burini, H.T. Kano, M.S. Nakagaki, T.C. Figueira, F.H. Burini. UNESP Medical School, Brazil and UEL/UEM Physical Exercise Graduate Program, Brazil. C124 II 639.48 Utilizing a Processing-Based Diet Index to Measure Change in BMI in a Population Undergoing a Nutrition Transition. E.L. Cooper. University of Michigan. C125 I 639.49 Economic Development and Associations with Growth of Preschool Children in the Middle East and North African Region. R.E. Jones, S. Cunningham. Emory Univeristy and Emory University. C126 II 639.50 Preconceptional Lipid-Based Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids in Guatemalan Women Who Are Overweight or Obese at 12 Weeks Gestation: A Pilot Study. S. Borengasser, M. Kerns, A. Palacios, P. Baker; II, J. Kemp, S. Morrison, J. Westcott, J. Friedman, A. Lucia Garces, L. Figueroa, M. Hambidge, N. Krebs. University of Colorado— Anschutz Medical Campus, University of Colorado—Denver, Medical School for International Health, Ben Gurion University of the Negev, Israel and Institute of Nutrition of Central America and Panama, Guatemala. C127 I 639.51 Changing Food Environments and Health Outcomes: Quantifying the Nutrition Transition in Global Nutrition Research. H.V. Becker, J.C. Eaton, L.L. Iannotti. Washington University in St. Louis. C128 II 639.52 Predicting and Modeling Follow-Up Clinic Visits (Persistence) After Bariatric Surgery. T. Brazell, J. Paynter, D. Thomas, K. Watts, D. Cottam. United States Military Academy and Bariatric Medicine Institute. C129 I 639.53 Dietary Trends in Energy, Carbohydrate, Protein, Fat, Sodium and Potassium Intake by Urbanicity Index in Chinese Adolescents from 1991 to 2011. A.L. Yu, N. LopezOlmedo, B. Popkin. University of North Carolina at Chapel Hill.

640. COMMUNITY AND PUBLIC HEALTH NUTRITION INTERVENTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C130 I 640.1 Assessing Nutrition Knowledge Using Healthy Plate Photo Method Among Youth Participating in WeCook. W. Chai, A. Walther, T. Dunker, L. Franzen-Castle, M. Krehbiel. University of Nebraska-Lincoln. C131 II 640.2 How Health-Related Signs Unexpectedly Promote Healthy Choices: Long-Term Conclusion for Nordic Cafeteria. B. Wansink, K.I. Karevold, S. Kallbekken, H. Tran. Cornell University, GreeNudge, Norway, University of Oslo, Norway and CICERO, Norway.

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C132 I 640.3 Supermarket Interventions That Encourage Sustainable Healthy Habits: Long Term Learning of Fresh Fish Sales in Grocery Stores. B. Wansink, K.I. Karevold, H. Tran. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C133 II 640.4 Feasibility of a Pilot Randomized Controlled Trial to Assess Health Impacts of Community Gardening. A.W. Beavers, K. Burr, K. Li, R. Pimentel, D. Glueck, J. Hebert, A. Masunaga Goto, L. Fahnestock, R. Knight, K. Alaimo, J. Litt. Michigan State University, University of Colorado School of Medicine, Colorado State University, University of Colorado School of Public Health, University of South Carolina, Brown University, Denver Urban Gardens, University of California San Diego and University of Colorado Boulder. C134 I 640.5 Vegetable Velocity: More Time in Aisle Means More Produce in Carts. B. Wansink, A. Mukund. Cornell University and University of Washington. C135 II 640.6 Conducting Behavioral Field Research in Food Pantries: Lessons and Tactics for Testing Nutrition Interventions. B. Wansink, H. Bhana. Cornell University and Columbia University. C136 I 640.7 First Foods Are Frequently Selected Most but in Smaller Amounts: Long-Term from Nordic Cafeteria. B. Wansink, K.I. Karevold, H. Tran. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C137 II 640.8 Impact of the National Crusade Against Hunger on Dietary Diversity in Mexican Women. M. MoralesRuán, B. Martínez Tapía, V. Mundo Rosas, T. Shamah-Levy, I. Mendez Gómez-Humarán. National Institute of Public Health, Mexico and Mathematics Research Center, Mexico. C138 I 640.9 Behaviour Change Communication Using Mobile Phones: Implications for Infant and Young Child Feeding Interventions. A. Mildon, D. Sellen. University of Toronto, Canada. C139 II 640.10 Iron Status of Reproductive Age Women in Northern Ghana Is Improved by Indigenous Hibiscus Sabdariffa Meal. C. Kubuga, S. Song, G. Kennedy, K. Lee, W. Song. Michigan State University, University for Development Studies, Ghana and Bioversity International, Italy. C140 I 640.11 Vitamin A Sugar Fortification in Zambia: Opportunities and Challenges. M. Greene, G. Kabaghe, M. Musonda, A.C. Palmer. Johns Hopkins Bloomberg School of Public Health and National Food and Nutrition Commission, Zambia. C141 II 640.12 Make-It-Yourself (MIY) Food Stations: Long-Term Healthy Lessons from Nordic Cafeterias. H.Q. Tran, B. Wansink, K.I. Karevold. Cornell University, GreeNudge, Norway and University of Oslo, Norway. C142 I 640.13 Mobilizing Markets: Community Efforts to Decrease Food Insecurity in Meadville, Pennsylvania. K. Martin, T. Hinton, D. Anderson, E.J. Schafer, R. Smullin Dawson. Allegheny College. C143 II 640.14 Impact of Health Workers Infant Feeding Practices Training on the Prevalence of Functional Constipation Among Children at Six Years Old. A Cluster Randomized Field Trial. C.N. Sangalli, M.B. de Morais, M.R. Vitolo. Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil and Universidade Federal de São Paulo, Brazil.

SUNDAY NUTRITION C144 I 640.15 Food Selection by According to Food Processing: Fabulous or Flawed. J.A. Jones. St. Catherine U. Emerita. C145 II 640.16 Reinforcement as a Parenting Strategy Related to Children Obesogenic Behaviors Is Associated to Mothers’ but Not Fathers’ Education Level Among Health Workshop Participants in Mexico City. A.B. Perez-Lizaur, A.C. Fernandez-Gaxiola, M. Damacio, L. Moreno-Landa. Universidad Iberoamericana, Mexico. C146 I 640.17 A Reliable Instrument of Health Literacy in Hospitalized Patients: 3-Question Brief Health Literacy Screen (BHLS). D. Dikmen, B. Madalı, A. Özdemir, E. İnanEroğlu. Hacettepe University, Turkey. C147 II 640.18 Design and Baseline Characteristics of a Study Comparing Four Supplementary Foods in the Prevention of Stunting and Wasting Among Children 6–23 Months in Burkina Faso. I. Cliffer, B. Langlois, D. Suri, S. Walton, L. Ouedraogo, A. Zeba, H. Lanou, F. Garanet, P. Webb, B. Rogers. Tufts University, University of Wisconsin and Ministry of Scientific Research and Innovation, Burkina Faso. C148 I 640.19 Healthy Eating, Mindfulness, Exercise, and Lifestyle in Overweight and Obese Postmenopausal Breast Cancer Survivors (HEELS): A Pilot Study—Approach, Feasibility, and Acceptability. E.L. Sattler, A.M. Washington, H.N. Young, E. Cobran, D. Hartzell, K.A. Dunagan, M. Davis. University of Georgia. C149 II 640.20 Experiences of Beneficiary Caregivers in a Supplementary Feeding Program in Southern Malawi. B. Langlois, D. Suri, S. Walton, B. Rogers. Tufts University and University of Wisconsin-Madison. C150 I 640.21 The Impact of Program Structure on Outcomes of the Illinois Junior Chefs Program. R. Liu, J.J. Metcalfe, E. Emberton, B. Fiese, J.J. McCaffrey. University of Illinois at Urbana-Champaign. C151 II 640.22 State of Hypertension, Diabetes Mellitus and Anemia Among Residents of Selected Communities in Ghana. M.A. Tandoh, E. Johnson, A.K. Anderson. University of Georgia. C152 I 640.23 Camp NERF: Caregiver Outcomes from a Theory-Based Nutrition Education Recreation and Fitness Program Aimed at Preventing Unhealthy Weight Gain in Underserved Children During Summer Months. L.C. Hopkins, A. Webster, A. Sharn, C. Gunther. The Ohio State University. C153 II 640.24 Pilot Study on Influencing Healthy Food Acceptance in Young Children Through Play-Based Activities and Food Exposures. A.G. Taetzsch, E. Hennessy, S. Taylor, A. Maaliki, D. Rao, L. Ng, A. Krauss, A. Wolfgang, A. Fleming, S. Das, C.D. Economos, S.B. Roberts. HNRCA/ Tufts University, Friedman School of Nutrition Science and Policy and Tufts University. C154 I 640.25 Determinants of Dietary Supplement Use and Compliance by US Adults. A. Bogale, D. MacKay, S.H. Mitmesser. The Natures Bounty Co. and The Council for Responsible Nutrition. C155 II 640.26 Population Health Interventions to Curb Intake of Sugars: Gaps in the Evidence. S. Kirkpatrick, M. Maynard, A. Raffoul, J. Stapleton. University of Waterloo, Canada.

C156 I 640.27 Perception and Barriers to CalFresh Utilization Among Asian Pacific Islander Communities in Southern California. N.P. Louie, L.P. Kim, S. Chan. Pepperdine University and Asian Pacific Islander Obesity Prevention Alliance (APIOPA). C157 II 640.28 Development and Testing of a Pilot Integrated Mental Health and Nutrition Education Program for Low-Income Families in Southern California. R.P. Spitz, L.P. Kim, J.H. Gavazza. Pepperdine University, Pepperdine University and Graduate School of Psychology and Education (GSEP). C158 I 640.29 Nutrition Education in a University Wellness Program. L.R. Menge, S.H. Crixell, L.K. Lloyd, J. Bezner. Texas State University. C159 II 640.30 Nutrition Knowledge and Dietary Practices Among Pre-Adolescent Children (6–11 Years Old) in Rural South Africa. B.A Z. Abu, W. Oldewage-Theron, E. Abdulkadir. Texas Tech University, Centre Vaal University of Technology, South Africa and Vaal University of Technology (VUT), South Africa. C160 I 640.31 Gender Differences in Dietary Attitudes and Behaviors of Participants in the Illinois Junior Chefs Program. E. Emberton, J.J. Metcalfe, R. Liu, B. Fiese, J. McCaffrey. University of Illinois at Urbana-Champaign. C161 II 640.32 Labeling Policy for Genetically Modified and Organic Food: Impact on Consumer Choice. S.M. Wunderlich, K.A. Gatto, M. Mangano. Montclair State University. C162 I 640.33 Half-Carts: Partitioned or Divided Grocery Carts Lead to Greater Fruit and Vegetable Purchases in Supermarkets. B. Wansink, D. Solman, K. Herbst. Cornell University, University of Toronto, Canada and Wake Forest. C163 II 640.34 Impact of the National Crusade Against Hunger (CNCH) on Anemia and Dietary Diversity Among Mexican Children. V. Mundo Rosas, T. Shamah Levy, B. Martínez Tapia, I. Méndez Gómez-Humarán. National Institute of Publich Health, Mexico, Mexico. C164 I 640.35 Overweight and Obesity in Mexican Children and Adolescents: Data from National Nutrition and Health Surveys in 2016. L. Cuevas-Nasu, T. Shamah Levy, M.A. Avila Arcos, I. Mendez Gomez, J. Rivera Dommarco. National Institute of Public Health, Mexico and Center for Research in Mathematics, Mexico. C165 II 640.36 Igniting Youth to Create Healthier Communities: Year 4 Policy Changes. K. Kattelmann, B. Chen, M. Erickson, S. Zies, M. Jess, Y. Li, N. Muturi, E. Lindshield, D. Remley, T. Kidd. South Dakota State University, Ohio State University Extension and Kansas State University. C166 I 640.37 Effectiveness of the Children’s Healthy Living (CHL) Multilevel Multicomponent Community Intervention Program in 5 US Affiliated Pacific Jurisdictions. R. Novotny, L.R. Wilkens, C.R. Nigg, K. Braun, J. Butel, A. Areta, P. Coleman, T. Belyeu-Camacho, J. Greenberg, A. Bersamin, R. Leon Guerrero, L.R. Barber, M.K. Fialkowski, E. De la Cruz-Talbert. University of Hawaii, American Samoa Community College, American Samoa, Northern Marianas College, Northern Mariana Islands, University of Alaska and University of Guam, Guam.

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NUTRITION SUNDAY C167 II 640.38 Social Media Marketing on Popular Sugar-Sweetened Beverages Facebook and Twitter Pages in Mexico. P. Hernández Chávez, A. Velasco Bernal, P. Aguilar Menéndez, B. Bolado Velázquez. Instituto Nacional de Salud Pública, Mexico. C168 I 640.39 Families with Preschool Children Meet Behavior Change Goals Using the Homestyles Express Breakfast the Right Start Guide Paired with Telephone Counseling. C. Delaney, J. McKinley, J. Martin-Biggers, C. Byrd-Bredbenner. Rutgers University. C169 II 640.40 Wellness Characteristics of College Freshmen at West Virginia University. A.M. Morris, M.L. Barr, O.A. Famodu, S.E. Colby, W. Zhou, R.L. Hagedorn, R.L. Clark, K. Riggsbee, M.D. Olfert. West Virginia University and University of Tennessee. C170 I 640.41 High-Energy Dense Food and SugarSweetened Beverages Are Most Likely Placed and Available at Special Displays in Stores of Mexico City. P. Aguilar, A. Velasco Bernal, B. Bolado Velázquez, P. Hernández Chávez. Instituto Nacional de Salud Pública, Mexico.

641. CHILDHOOD OBESITY/SCHOOLBASED EDUCATION Poster (Sponsored by: Community Nutrition and Public Health RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C171 I 641.1 The Victoria Trial: A School-Based Health Education Program to Reduce the Risk of Obesity Among a High-Risk Population. M.A. Mejia, A. Coria-Navia, G. Uriegas-Mejia, S.C. Brown-Fraser, S.E. Uriegas, M. Martinez, A. Sanchez, M.E. Acosta, A.E. Ramirez, R.E. Reyes, Y.C. Hernandez, D.Y. Camacho, G. Morrow, G. Krivak. Andrews University, Opti Health, PLLC, Secretaria de Salud de Tamaulipas, Mexico, Weimar Institute, Universidad de Montemorelos, Mexico and Secretaria de Educacion Publica, Mexico. C172 II 641.2 A Qualitative Examination of Barriers and Facilitators to Physical Activity for Rural Adolescents. B. Chen, K. Kattelmann, A. Daniels, S. Zies, E. Lindshield, T. Kidd. South Dakota State Univerisity, South Dakota State University, Ohio State University and Kansas State University. C173 I 641.3 The Association Between Children’s Weight Status Awareness and Nutritional, Physical Activity Knowledge, Attitude and Behavior in Rural Taiwan. H. Yang, Y. Lin, H. Wu, H. Chen. Mackay Medical College, Taiwan and National Yang-Ming University, Taiwan. C174 II 641.4 Cooking with Kids: Eating the Same but Behaving Better. H. Kessler, B. Wansink, C.M. Velez Argumedo. Cornell University and EGADE Business School, Mexico.

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C175 I 641.5 The Hidden Persuaders: Childhood Eating Patterns That Correlate with Weight Gain and Obesity. H. Kessler, C.O. Werle, B. Wansink. Cornell University and Grenoble Ecole de Management, France. C176 II 641.6 Branding Techniques and Their Impact on Healthy Selection in School Cafeterias. G. Gabrielyan, B. Wansink, D.R. Just, A.S. Hanks, A. Brumberg. Cornell University and Ohio State University. C177 I 641.7 A Systematic Review of Randomized Clinical Trials Examining Effects of Breakfast Composition on Weight Outcomes Among Children and Adolescents. Z. Fu, H. Almahmassani, M. Chung, C. Cook. Tufts University School of Medicine, Tufts University Friedman School of Nutrition Science and Policy and Biofortis. C178 II 641.8 Four-Year Follow Up of an Integral Health Program to Control Parameters Associated with Childhood Obesity. N.G. Valenzuela-Rubio, F.H. CastroSanchez, M.J. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico. C179 I 641.9 The Perception of School Milk Program and Consumption of Calcium Source of Middle School Students in Gyeonggi, Korea. H. Lee, G. Park. Daejin University, Republic of Korea. C180 II 641.10 Development of a Health Education Curriculum to Reduce the Risk of Obesity Among Hispanic School-Age Children. M.A. Mejia, A. Coria-Navia, G. UriegasMejia, S.C. Brown-Fraser, S.E. Uriegas, M. Martinez, A. Sanchez, M.E. Acosta, A.E. Ramirez, R.E. Reyes, Y.C. Hernandez, D.Y. Camacho, G. Morrow, G. Krivak. Andrews University, Opti Health, PLLC, Secretaria de Salud de Tamaulipas, Mexico, Weimar Institute, Universidad de Montemorelos, Mexico and Secretaria de Educacion Publica, Mexico. C181 I 641.11 A Comparative Study on Dietary Habit and Nutrition Knowledge of Middle School Students in Seoul Area, Korea. Y. Kim, S. Cho. Inha University, Republic of Korea. C182 II 641.12 A Comparative Study on Dietary Habit and Weight Control of Middle School Students in Gyonggi-Do, Korea. Y. Kim, S. Yang. Inha University, Republic of Korea. C183 I 641.13 The Locus of Control and Likelihood of Success: Evidence from School Lunchrooms. G. Gabrielyan, K. Greene, D.R. Just, B. Wansink. Cornell University. C184 II 641.14 Implementation of an Adapted GardenEnhanced Nutrition Curriculum for Use Among Fourth-Grade Students in an Urban City in Mexico: A Feasibility Study. J. Rodriguez-Jordan, L.E. Vera-Becerra, N.B. Smith, S. Zidenberg-Cherr. University of California, Davis, University of Guanajuato and Campus León, Mexico. C185 I 641.15 Development and Dissemination of a Learner-Centered Nutrition Curriculum for School Nutrition Services Staff. A.M. Jones, J. Bergman, M. Briggs, K. Brian, S. Zidenberg-Cherr. University of California, Davis, University of California Cooperative Extension and University of California Agriculture and Natural Resources.

SUNDAY NUTRITION

642. CHILDHOOD OBESITY: CAUSES, CORRELATIONS, AND TREATMENT

(Sponsored by: Obesity RIS)

C197 II 642.12 Presence of a Risk FTO Polymorphism in Young Adults from Northwestern Mexico and Its Association with Biomarkers of Overweight and Obesity. H. AstiazaranGarcia, A. Rendon-Del Cid, E. Urias-Cazarez, B.I. PachecoMoreno, G.G. Morales-Figueroa, I. Anduro-Corona. CIAD, Mexico.

Sun. 9:00 am—McCormick Place Convention Center, Hall F

643. OBESITY I

Poster

Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C186 I 642.1 Associations of Breastfeeding, Diet Quality and Physical Activity with BMI in Adolescents. E. Shields, L. Shanahan, L. Wideman, S. Calkins, S. Keane, C. Lovelady. University of NC at Greensboro and University of Zurich, Switzerland. C187 II 642.2 Association Between Weight-Related Health Behaviors and Weight Perception in Adolescents with Overweight or Obesity. K.A. Borton, S.L. Hahn, K.R. Sonneville. University of Michigan. C188 I 642.3 Education Level Influences WeightRelated Cognitions and Behaviors of Parents with Preschoolers. K. Eck, V. Quick, J. Martin-Biggers, C. Delaney, C. ByrdBredbenner. Rutgers University. C189 II 642.4 Eating Frequency and the Role of Snacking on Weight of Minority Preschool Children. A. Charvet, F.G. Huffman. Florida International University. C190 I 642.5 Physical Activity, Sedentary Behavior, and Obesity in U.S. Children Ages 6–12. P. Haddadian, M. Huwaikem, J.A. Vaccaro, G.G. Zarini, F.G. Huffman. Florida International University. C191 II 642.6 Maternal Perception of Child Overweight Status and Its Impact on Parenting Practices, Their Children’s Health Behaviors and Weight Change in China. J. Min, V.H. Wang, H. Xue, J. Mi, Y. Wang. Ball State University, Wagner School of Public Service, New York University, Capital Institute of Pediatrics, People’s Republic of China. C192 I 642.7 What Words and Actions Predict Adult and Daughters Weight Satisfaction? H.Q. Tran, B. Wansink, D.C. Christian. Cornell University and BI Norwegian Business School, Norway. C193 II 642.8 Away from Home Eating Is Associated with Increases in Dietary Energy Density in US Children: Findings from the National Youth Fitness Survey. A. Tacinelli, J.A. Vernarelli. Fairfield University. C194 I 642.9 Effects of Dried Apple Consumption on Body Composition, Inflammatory Markers and Lipid Profile in Overweight and Obese Children. P. Nagarajan, A. Tunstall, L. Almaiman, C. Cabalbag, D. Metti, M. Hong, M. Kern, S. Hooshmand. San Diego State University. C195 II 642.10 Saturated Free Fatty Acids Induce Trophoblast Lipoapoptosis. S. Natarajan, T. Bruett, E. Muthukrishnan, M. Islam, J.L. Mott. University of NebraskaLincoln and University of Nebraska Medical Center. C196 I 642.11 Effects of a 12-Week Lifestyle Intervention in a Mixed Sample of Rural Youth with Obesity. K. Johnson, D. Nicoara, R. Sorrells, J.P. Yi-Frazier, K. Briggs Early. Pacific Northwest University of Health Sciences and Seattle Children’s Research Institute.

Poster (Sponsored by: Obesity RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C198 I 643.1 Does Monitoring Your Hunger via Blood Glucose Help You Eat to Appetite and Lose Weight? M.R. Jospe, R.W. Taylor, J. Athens, M. Roy, R.C. Brown. University of Otago, New Zealand. C199 II 643.2 The 25-Day Tipping Point: Everyday Adherence Has Multiplicative–Not Additive–Benefits to Weight Loss. D.R. Just, R.W. Patterson, B. Wansink. Cornell University and United States Military Academy. C200 I 643.3 A Double Blind, Randomized, PlaceboControlled Study of Salacia Chinensis, with Alpha-Glucosidase Inhibitor Properties, on Post-Prandial Glycemia. L. Hao, K. Fieselmann, S. Schneider, Y. Schlussel, S. Shapses. Rutgers University and Rutgers-Robert Wood Johnson University Hospital. C201 II 643.4 A Comparison of Protein and Fiber Content in 52 Chain Restaurant Menus. Y. Wang, R. Lau, D.S. Brown, J. Cino, R. Jung, M. Mizuki, M. Wang, S. You, M.T. Nakamura. University of Illinois at Urbana-Champaign. C202 I 643.5 The Critical Role of Individual Trait Differences in Transcranial Direct Current Stimulation Outcomes: Effects in a Sample with Non Binge-Eating Obesity. M. Ray, M.D. Sylvester, L. Osborn, J. Helms, B. Turan, M. Boggiano. University of Alabama at Birmingham. C203 II 643.6 Does Higher Protein Quality Breakfast Reduce Energy Intake When Following a Weight Loss Diet Plan. D. Bailey, A. Childress, A. Shastri, G. Anderson, V. Hegde, J.A. Dawson, N.V. Dhurandhar. Texas Tech University. C204 I 643.7 Nutritional Status 6 Weeks After Gastric Bypass Bariatric Surgery: Comparison of Two Nutritional Support Plans. R. DiSilvestro, P. Choban, F. Aguila. Medinutra LLC and Mt Carmel Hospital. C205 II 643.8 Birth Weight, Early Life Weight Gain and Age at Menarche: A Systematic Review of Longitudinal Studies. F. Juul, V. Chang, P. Brar, N. Parekh. NYU College of Global Public Health, NYU School of Medicine, Steinhardt School of Culture, Education, and Human Development and New York University. C206 I 643.9 Visceral Adiposity Index in Prediabetes and Diabetes: The Polish Norwegian Study (PONS). G. Vaidean, M. Manczuk, S. Vansal. Fairleigh Dickinson University, Icahn School of Medicine at Mount Sinai and Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Poland.

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NUTRITION SUNDAY C207 II 643.10 Protein Carbonylation Is Related to Liver Damage in an Experimental Model of Obesity. F. Moreto, A. Ferron, F. Francisqueti, F. Hasimoto, J. Garcia, L. Ghiraldeli, E. Ribeiro, C. Correa, A. Ferreira. Sao Paulo State University, Brazil. C208 I 643.11 Heart Inflammation Is Associated to Carbohydrate-Enriched Diet in an Experimental Model of Obesity. A.A. Ferreira, A.J. Ferron, F. Moreto, F.V. Francisqueti, K.A. Kitawara, A.T. Lo, A.C. Ferraz, J.L. Garcia, L. Ghiraldeli, C.R. Correa. Botucatu Medical School, Sao Paulo State University, Brazil, Brazil and Sao Paulo State University, Brazil. C209 II 643.12 Interrelationship Between Total and Undercarboxilated Osteocalcin Levels, and Body Mass Index in Women. L. Zago, C. González Infantino, S. Zeni, M. Río, A. Felipoff, A. Weisstaub, H. Dupraz, N. Presner. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Nutrición, Argentina, Universidad de Buenos Aires and Hospital de Clínicas, Argentina. C210 I 643.13 Obesity and Weight Loss Pre-Kidney Transplantation. E. Tantisattamo. Oakland University William Beaumont School of Medicine. C211 II 643.14 Machine Learning Approach to Identify Optimal Criteria for Successful Weight Loss Maintenance on the Basis of Cardiometabolic Risk Factors at Year 4 of the Look AHEAD Trial. S.E. Berger, G.S. Huggins, J.M. McCaffery, P.F. Jacques, A.H. Lichtenstein. Friedman School of Nutrition Science and Policy, Tufts University, Tufts Medical Center and Tufts University Sackler School of Graduate Biomedical Sciences, Miriam Hospital and Warren Alpert School of Medicine, Brown University, JM USDA Human Nutrition Research Center on Aging and Tufts University. C212 I 643.15 Umami Taste Perception Following Dietary Glutamate Supplementation. C.A. Noel, R. Dando. Cornell University. C213 II 643.16 Dietary Fatty Acid Composition Impacts Plasma Fatty Acid Ethanolamides and Body Composition in Golden Syrian Hamsters. J. Sihag, D.J. Jones. University of Manitoba, Canada. C214 I 643.17 Effects of A High-Fat Diet on Spontaneous Locomotor Activity and Blood Metabolic Biomarkers in Sprague Dawley Rats. W. Chia-Ying, Y. Yang, C. Chen, J. Chang, S. Tsai, C. Chen, C. Chen, J. Bernard, Y. Liao. National Taipei University of Nursing and Health Sciences, Taiwan, University of Taipei, Taiwan, Chang Gung University, Taiwan, California State University at Stanislaus. C215 II 643.18 The 2015 Dietary Guidelines for Americans: Adherence to Key Recommendations in Hispanic Females. B. Hannon, E. Villegas, A. Wiley, M. Teran-Garcia. University of Illinois at Urbana-Champaign. C216 I 643.19 Femur Cortical Bone Mineral Content Is Increased with High Protein Intake During Ad Libitum But Not Energy Restricted Conditions in Obese Female Zucker Rats. P. Marszewski, S.R. Hennigar, A.M. Kelley, B.J. Anderson, J.P. McClung, E. Gaffney-Stomberg. United States Army Research Institute of Environmental Medicine. C217 II 643.20 Anti-Obesity Effects of Solar Salt Prepared from Concentrated New Sea Water on 3T3-L1 Adipocytes. K. Park, E. Park, J. Ju, S. Choi. Cha University, Republic of Korea, Yonsei University, Republic of Korea, Docho Salt Co., Republic of Korea.

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C218 I 643.21 Red Sweet Cherry Ameliorates Inflammation in Obese Diabetic (db/db) Mice. G. Noratto, B.P. Chew, S.U. Mertens-Talcott. Texas A&M University. C219 II 643.22 Regulation of Gene Expression of Wnt Signaling Pathway by Dietary High Fat and Effects on Colon Epithelia of Male Mice. G. Xu, R. Emmons, D. HernándezSaavedra, A. Kriska, Y. Pan, H. Chen. University of Illinois at Urbana-Champaign. C220 I 643.23 Changes in Food Cravings During Dietary Carbohydrate Restriction. C. Heimowitz, M. Syed Abdul, Q. Hu, N. Le, K. Bingham, V. Cox, E.J. Parks. Atkins Nutritionals, Inc and University of Missouri. C221 II 643.24 Effects of Consuming a High Protein Diet with or Without Soy Protein on Transformative Weight Loss and Maintenance: A Non-Inferiority, Randomized Clinical Efficacy Trial. K.J. Speaker, J.C. Peters, H.K. Nelson, Z. Pan, H. Wyatt, M. Flock, R. Mukherjea, J.O. Hill. University of Colorado Anschutz Medical Campus and Dupont Nutrition and Health. C222 I 643.25 Dietary Diversity in Mexican Adolescents from a 2016 National Survey. E.B. GaonaPineda, S. Rodriguez-Ramirez, B. Martinez-Tapia, D.G. Valenzuela-Bravo, L.M. Gomez-Acosta, T. Shamah-Levy. National Institute of Public Health, Mexico. C223 II 643.26 Dietary Diversity in Mexican PReschool Children: Data from National Nutrition and Health Surveys in 2016. L.M. Gómez-Acosta, E.B. Gaona-Pineda, S. RodriguezRamirez, B. Martínez-Tapia, D.G. Valenzuela-Bravo, T. Shama-Levy. Instituto Nacional de Salud Pública, Mexico. C224 I 643.27 Effects of Dietary Vitamin D Deficiency and High Fat Feeding on Adiposity, Food Intake, and Cortical Serotonin in Mature Mice. Y. Wang, S.A. Shapses, N.T. Bello, J.W. Miller. Rutgers University. C225 II 643.28 Screen Time Is Associated with Lower Healthy Eating Index (HEI)-2010 Total Score in Low-Income Hispanic Pregnant Women in the Starting Early Study. L.T. Berube, K. Woolf, R. Gross, M.J. Messito. New York University, Albert Einstein College of Medicine and New York University School of Medicine. C226 I 643.29 I’m Staying in Tonight: Cooking at Home Predicts Lower Dietary Energy Density and Lower Risk for Obesity in a Nationally Representative Sample of US Adults. S. Sawicki, J.A. Vernarelli. Fairfield University. C227 II 643.30 Effects of a 12-Week Telenutrition Weight Loss Intervention on Diet Quality in Men. A. Kapostasy, M. Drazba, M. Shotwell, M.V. Marra. West Virginia University and Vanderbilt University. C228 I 643.31 Dietary Patterns of African American and Caucasian Females Seeking Bariatric Surgery. K. McLean, C. Moore, D. Miketinas, C. Champagne. Texas Woman’s University, Louisiana State University and Pennington Biomedical Research Center. C229 II 643.32 Evaluation of a Novel Bioimpedance Analysis Equation Development Approach. J. Zheng, B. Bourgeois, S.B. Heymsfield. Pennington Biomedical Research Center and Louisiana State University.

SUNDAY NUTRITION C230 I 643.33 Television Watching Is Positively Associated with Body Composition Among Adults with High Genetic Predisposition to Obesity: Population-Based Study in South China. H. Xue, J. Zhang, D. Li, J. Luo, G. Cheng. Sichuan University West China School of Public Health, People’s Republic of China. C231 II 643.34 Percent Body Fat Determination: Influence of Bone Mineral in Female Athletes. D.M. Foote, C.A. Horswill. University of Illinois at Chicago. C232 I 643.35 The Cross-Sectional Association Between Eating Frequency and Body Composition Among Adults in South China. Y.-y. Chen, H. Xue, J. Yin, G. Cheng. West China School of Public Health, ichuan University, People’s Republic of China. C233 II 643.36 Comparison of Body Fat Measurement Using Bioimpedance or Plicometry in Normal and Obese Subjects: An Internal Validation Study. F.H. Castro-Sanchez, N.G. Valenzuela-Rubio, M. Vergara-Jimenez. Universidad Autonoma de Sinaloa, Mexico. C234 I 643.37 Dietary Intake and Breastfeeding Practices Differ Between Women Who Gain Versus Lose Muscle Mass from 3 to 9 Months Postpartum. S.A. Elliott, L.C. Pereira, L.J. McCargar, C.C. Prado, R.C. Bell. University of Alberta, Canada. C235 II 643.38 Plasma Volume in Healthy Reproductive Age Women Using Indocyanine Green Dye. S. Aguree, A. Gernand. The Pennsylvania State University. C236 I 643.39 Associations Between Neck Circumferences and Measures of Health in Young Adults. O.A. Famodu, M.L. Barr, S.E. Colby, W. Zhou, C. Bryd-Bredbenner, A.E. Mathews, M.D. Olfert. West Virginia University, University of Tennessee, Rutgers University and University of Florida. C237 II 643.40 Intermuscular Adipose Tissue According to Obese Phenotype in Korean Obese Individuals. J. Yim, Y. Kim. Changwon National University, Republic of Korea, Jung Hopital, Republic of Korea.

644. NUTRIENT GENE INTERACTIONS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C238 I 644.1 Increased Transcription of the SeryltRNA Synthetase (SARS) Gene in Response to Amino Acid Limitation Is Mediated by an Intronic C/EBP-ATF Response Element (CARE) That Functions as an Distal Enhancer. J. Shan, J. Sharkey, S. Tsang, M.S. Kilberg. University of Florida College of Medicine. C239 II 644.2 Nutrient Transporter Expression in Bovine Utero-Placental Tissue Is Altered by the Supply of Dietary Methionine During Late-Gestation. F. Batistel, A.S. Alharthi, C. Parys, B. Saremi, J. Loor. University of Illinois and Evonik Nutrition & Care GmbH, Germany. C240 I 644.3 Diet and MicroRNA Expression: A Systematic Review. S.A. McNaughton, J. Danaher, A.P. Russell. Deakin University, Australia.

C241 II 644.4 Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxyvitamin D3 Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells. J. Daleprane, T. Texeira, F. Bezerra. Rio de Janeiro State University, Brazil. C242 I 644.5 Carriers of Polymorphisms of Antioxidant Enzymes CAT-21 (A>T; rs7943316), SOD-1 -251 (rs2070424) and Sod-2 (rs4880) Present a Better Response on Cardiovascular Risk Indicators After a Dietary Intervention. C. Hernández, P. Hernández Chávez, A. Parra Carriedo, D. Juagardo Lopez, S. Ramirez Del Alto, A. Pérez Lizaur. Universidad Iberoamericana, Mexico. C243 II 644.6 LCT Gene Variant (-13910C>T) and the Plasma Proteome: A Mendelian Randomization Study. O. Alharbi, A. El-Sohemy. University of Toronto, Canada. C244 I 644.7 Effect of Histone Deacetylase Inhibitors on Vitamin D Dependent Gene Expression in Human Colorectal and Breast Cancers. S. Hossain. University of Massachusetts Amherst. C245 II 644.8 Characterization of Expression Levels of Genes Involved in Adipogenesis and Inflammation in Congenic Mice Carrying Obesity and Hyperlipidemia QTL on Chromosome 1 J.K. Parkman, J. Kim. Joan C. Edwards School of Medicine and Marshall University. C246 I 644.9 Supplementation with ω3 Polyunsaturated Fatty Acids Decreases Fasting Insulin and Hemoglobin A1c Levels in Healthy Mexican Adults: The Role of PPAR&γ2 P12a. A. Binia, L. Gosoniu, D. Martínez-Soria, F. Vadillo-Ortega, P. Valet, M. Kussmann, I. Silva Zolezzi, M. Tejero. Nestlé Research Center, Switzerland, Unidad de Vinculación de la Facultad de Medicina, Mexico, Institut des Maladies Metaboliques et Cardiovasculaires, France, The Liggins Institute, New Zealand and Instituto Nacional de Medicina Genómica (INMEGEN), Mexico. C247 II 644.10 Genetic Variation in CholineMetabolizing Enzymes Alters Choline Dynamics in Women Meeting Current Dietary Recommendations. A.B. Ganz, V.V. Cohen, C.C. Swersky, J.A. Stover, G.A. Vitiello, J. Lovesky, J. Chuang, K. Shields, V.G. Fomin, Y.S. Lopez, S. Mohan, A. Ganti, B. Carrier, O. Malysheva, M.A. Caudill. Cornell University. C248 I 644.11 Single Nucleotide Polymorphisms in FADS2, CETP and LPL and the Associations with Blood Lipids and Fatty Acids Differ in a Sex-Specific Manner. S.L. Klingel, K. Roke, D.M. Mutch. University of Guelph, Canada. C249 II 644.12 Associations Between Single Nucleotide Polymorphisms in Vitamin D Metabolic Pathway Genes and Serum 25(OH)D Concentrations in Brazilian Adults: The Pró-Saúde Study. F.F. Bezerra, A.P. da Fonseca, V.M. Zembrzuski, M.C. Junior, P.H. Cabello, E. Faerstein. Universidade do Estado do Rio de Janeiro, Brazil, Instituto Oswaldo Cruz—Fiocruz, Brazil and Universidade do Grande Rio, Brazil. C250 I 644.13 Prenatal Exposure to a Maternal LP Diet Decreases BDNF Expression in the Brains of the Neonatal Offspring. G. Marwarha, K. Claycombe, J. Lilek, O. Ghribi. University of North Dakota, U.S. Department of Agriculture, Agricultural Research Service and Grand Forks Human Nutrition Research Center. C251 II 644.14 Withdrawn.

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NUTRITION SUNDAY C252 I 644.15 Gene Expression and Epigenetic Regulations in Reshimax Anti-Aging Effect. Y. Ren, J. Lu, L. Gao, Y. Yao, J. Yang, Y. Zhang, D. Stevenson, M. Bartlett. Nu Skin (China) Daily-use & Health Products Co., Ltd., Center of Anti-aging Research, People’s Republic of China, and Nu Skin Enterprises. C253 II 644.16 Interaction Between the Ratio of Polyunsaturated Fat and Saturated Fat Intake and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α (PPARGC1A) rs4235308 Polymorphism in Relation to the Risk of Type 2 Diabetes in Cuban American Population. L. Xu, A. Cheema, G.G. Zarini, T. Li, F.G. Huffman. Florida International University and Nova Southeastern University. C254 I 644.17 Correlation of mRNA Levels with CpG Methylation Status of Genes Regulated by Fatty Acids in Differentiated Adipocytes. Y. Li, E. Cheng, B. Bower. Texas A&M University-Kingsville. C255 II 644.18 Epigenetic Regulation of Tumor Necrosis Factor (Tnf) in Skeletal Muscle by Chronic Caloric Restriction. D. Hernandez-Saavedra, Z.J. Goldberg, A.P. Wang, H. Chen, Y. Pan. University of Illinois at Urbana-Champaign. C256 I 644.19 Meta-Analysis of 19,005 Individuals Identifies Interplay Between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome, to Modulate Insulin Resistance and Diabetes Risk. A.M. Murphy, L. Murphy, C.E. Smith, J. Follis, T. Tanaka, M. Helminen, R. Lemaitre, T. Voortman, A. Dehghan, D. Mook-Kanamori, E. Marouli, K. Richardson, J. Dupuis, J. Meigs, P. O’ Gaora, J. Ordovas, H. Roche. University College Dublin, Ireland, Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University., Department of Mathematics, University of St. Thomas, Houston, Translational Gerontology Branch, National Institute on Aging, Baltimore, School of Health Sciences, University of Tampere, Finland, Department of Medicine, University of Washington, Department of Epidemiology, Erasmus MC University Medical Center, Netherlands, Department of Epidemiology, Erasmus MC-University Medical Center, Netherlands, Department of Clinical Epidemiology, Leiden University and Medical Centre, Netherlands, William Harvey Research Institute, The London School of Medicine and Dentistry, United Kingdom, Department of Biostatistics, Boston University School of Public Health, Division of General Internal Medicine and Massachusetts General Hospital. C257 II 644.20 Regulation of Endogenous Dusp4 by Agonist-Specific MAPK Activation in Adipocytes. W. Guo, B.S. Ferguson, R.F. Morrison. University of North Carolina Greensboro. C258 I 644.21 Characterization of Stability of the Young Porcine Intestinal Alkaline Phosphatase as a Candidate Exogenous Biocatalyst. T. Archbold, N.A. Burello, W. Wang, D.P. Bureau, M.Z. Fan. University of Guelph, Canada. C259 II 644.22 Sugar-Sweetened Beverage Intake as a Modulator of Genetic Associations for Chronic Inflammation Relevant to Cardiovascular Disease. D.C. Bartone, N.M. McKeown, K.R. Morrish, C.E. Smith, C. Lai, L.D. Parnell, J.M. Ordovas. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University Friedman School of Nutrition Science and Policy, United States Department of Agriculture, Agricultural Research Service and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

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C260 I 644.23 Oncostatin M Regulation of Adipocyte Differentiation Through Cell Cycle Arrest in 3T3-L1. D.M. DeSilva, R.F. Morrison. University of North Carolina Greensboro. C261 II 644.24 Dietary Effects on A2AR Expression in Liver and Adipose Tissues: A Role for A2AR in Protecting Against Inflammation and Insulin Resistance in Obesity. Y. Pei, Y. Cai, H. Li, S. Woo, M. Liu, Y. Huo, C. Wu. Texas A&M University and Augusta University.

645. AGING AND NUTRITION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C262 I 645.1 Effects of Protein Supplementation on Frailty and Sarcopenia in Pre-Frail and Frail Elderly: Study Protocol for a Dose-Response, Double-Blind, Randomized Placebo-Controlled Trial. Y. Park, S. Kwon. Hanyang University, Republic of Korea. C263 II 645.2 The Effects of Age on the Gut and Brain: Insights Into the Gut-Brain Axis. J. Hoffman, V. Bakshi, I. Parikh, J. Guo, R. Armstrong, S. Green, A. Lin. University of Kentucky and University of Illinois at Chicago. C264 I 645.3 The Relation of Dietary Pattern and Telomere Length Among Adults in South China. H. Xue, G. Tian, D. Li, J. Zhang, G. Cheng. Sichuan University, People’s Republic of China. C265 II 645.4 Association Between Dietary Protein Intake and Grip Strength Among Adults Aged 51 Years and Over: What We Eat in America, National Health and Nutrition Examination Survey 2011–2014. S. Mishra, J.D. Goldman, N.R. Sahyoun, A.J. Moshfegh. University of Maryland and Beltsville Human Nutrition Research Center. C266 I 645.5 Evidence Mapping: Dietary Fiber Interventions and Bone Health Outcomes. K.M. Rancaño, D. Haslam, C.M. Sawicki, K.A. Livingston, S. Sahni, M. Chung, N.M. McKeown. Friedman School of Nutrition Science and Policy, Tufts University, JM USDA HNRCA at Tufts University, Musculoskeletal Research, Institute for Aging Research at Harvard Medical School, Department of Public Health and Community Medicine and School of Medicine at Tufts University. C267 II 645.6 The Effects of Soy Protein Supplementation on Lipid Profiles and Bone Biomarkers. K.S. George, S.A. Johnson, S. Pourafshar, N. Navaei, B.H. Arjmandi. Florida State University and Colorado State University. C268 I 645.7 Serum Phosphate (sPO4) Is Lower in Older Kidney Transplant Recipients and Related to Low Phosphorous and Protein Intake and Not Urinary Losses. S. Mincer, E. Ruff, M. Markell. SUNY Downstate Medical Center. C269 II 645.8 Evaluation of Antioxidant Activity of Umbelliferae Plants. J. Lee, Y. DIng, J. Kim. Kongju National University, Republic of Korea.

SUNDAY NUTRITION C270 I 645.9 Genistein in Combination with Fructooligosaccharides Prevents Bone Loss in Ovariectomized Rats. S. Pourafshar, N. Navaei, S.A. Johnson, S.C. Chai, S. Hooshmand, B.H. Arjmandi. Florida State University, Center for Advancing Exercise & Nutrition Research on Aging, Florida State University, Colorado State University, University of Delaware and San Diego State University. C271 II 645.10 Regular Apple Consumption Improves Lipid Profiles in Overweight Postmenopausal Women. N. Navaei, S. Pourafshar, S.A. Johnson, S. Hooshmand, S.C. Chai, B.H. Arjmandi. Florida State University, Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Colorado State University, San Diego State University and University of Delaware. C272 I 645.11 Dietary Pattern Associated with Frailty: Results from Nutrition and Health Survey in Taiwan. W. Pan, Y. Lo. Institute of Biomedical Sciences and Academia Sinica, Taiwan. C273 II 645.12 Protein Fortification of a Typical Biscuit Recipe. M.E. Johnson, E.M. Cress, K. Riddle, K. Webb, W.A. Clark. East Tennessee State University. C274 I 645.13 Dried Plum Consumption Modulates Bone Turnover Biomarkers in Postmenopausal Women with Osteopenia. N.S. Akhavan, R.L. Saadat, S. Hooshmand, S.C. Chai, S.A. Johnson, S. Pourafshar, B.H. Arjmandi. Florida State University, Center for Advancing Exercise and Nutrition Research on Aging, San Diego State University, University of Delaware and Colorado State University. C275 II 645.14 Alaskan Berry Treatments Maintain C. elegans Motility and Sarcomere Integrity with Age. F. Touray Jr, M. Maulik, C. Scerbak, E. Vayndorf, A. Bult Ito, B. Taylor. University of Alaska Fairbanks, Earlham College, California State University at Long Beach. C276 I 645.15 Effects of Dried Plum and Chokeberry on D-Galactose-Induced Aging Model. O. Jeong, H. Jeong, Y. Liu, H. Kim. Sookmyung Women’s University, Republic of Korea. C277 II 645.16 Studies on the Storage Life of Almond Nut (Prunus amygdala var dulcis) Milk Using Pawpaw (Carica papaya) Extract as Local Preservative. I. Banjoko, O. Oyelola, O. Olatidoye, J. Oyegbola. Yaba College of Technology, Nigeria. C278 I 645.17 The Effects of Ipriflavone, Isoflavone, and 17B-Estradiol on Body Composition in Hamster Models of Ovariectomy. E.M. Foley, S. Pourafshar, N. Navaei, N.S. Akhavan, K.S. George, B.H. Arjmandi. Florida State University and Center for Advancing Exercise and Nutrition Research on Aging. C279 II 645.18 Effect of Long-Term Supplementation Lactobacillus paracasei on Body Composition in SenescenceAccelerated Mouse P8 (SAMP8). L. Li, C. Chan, C. Kuo, W. Chen, H. Ku, Y. Lian, H. Huang. Shin Chien University, Taiwan and Tatung University, Taiwan. C280 I 645.19 Long Term Probiotics administration Alleviates Immunosenescence in Senescence-Accelerated Mouse Prone 8 (SAMP8). C. Kuo, C. Chan, L. Li, W. Chen, H. Ku, Y. Lian, H. Huang. Shih Chien University, Taiwan and Tatung University, Taiwan. C281 II 645.20 Age-Related Decrease of Neurotransmitters in Senescence-Accelerated-8 Mice. C-H. Chan, L-A. Li, C-Y. Kuo, W-L. Chen, Y-Z. Lian, H-H. Ku, H-Y. Huang. Shih Chien University, Taiwan and Tatung University, Taiwan.

C282 I 645.21 Potential Skin Anti-Aging Effects of Korean Medicinal Plant Extracts. J.N. Averilla, J. Kim, S. Ju, J. Oh, J. Kim. Kyungpook National University, Republic of Korea. C283 II 645.22 Male and Female Sex Hormones Modulate the Effects of Hepatic Rictor Deletion on Glucose Metabolism and Lifespan. S.I. Arriola Apelo, C.P. Pumper, M.T. Morrison, E.J. Meyer, N.E. Cummings, A. Lin, E.L. Baar, D.W. Lamming. University of Wisconsin-Madison. C284 I 645.23 The Effect of Dietary Protein Levels and Branched-Chain Amino Acid Supplementation on Body Composition of Aging C57BL/6 Male Mice. W. Mu, E. Vanhoosier, E. Jiang, R. Grant. Purdue University. C285 II 645.24 Decreased Consumption of Specific Macronutrients Promotes Metabolic Health and Longevity. N.E. Cummings, A. Radcliff, A. Brodbeck, E. Konon, J. Wu, D. Sherman, E. Williams, S. Arriola Apelo, M. Barnes, T. Hacker, D. Lamming. University of Wisconsin-Madison. C286 I 645.25 Prevalence of Lactose Intolerance in Patients on Proton-Pump Inhibitors. S. Rana, P. CR, A. Malik, S.K. Sinha, R. Kochhar. Post Graduate Institute of Medical Education and Research, India.

646. DIETARY BIOACTIVE COMPONENTS I Poster (Sponsored by: Dietary Bioactives Components RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C287 I 646.1 A Targeted UHPLC-MS Approach to Quantify Phenolics in Muscadine Grape Supplements. A.V. Duncan, N.T. Pirro, A. Tallant, P.E. Gallagher, M.C. Chappell. Wake Forest School of Medicine. C288 II 646.2 The Gaps Between Nutrition Support Guidelines and the Applications of Parenteral Nutrition. T. Bayrak, H. Kiehl, C. LaSalle. San Jose State University and Santa Clara Valley Medical Center. C289 I 646.3 Phenolic Compounds as Functional Ingredients and Nutraceuticals: The Case of Juice PLUS+. D. Del Rio, L. Bresciani. University of Parma, Italy. C290 II 646.4 The Role of the Gut Microbiome in Quercetin Inhibition of Sulforaphane Bioavailability and Bioactivity in Rats. Y. Wang, X.C. Liu, T. Becker, S.M. Song, J.A. Juvik, M.J. Miller, E.H. Jeffery. University of Illinois. C291 I 646.5 Identification of Metabolite Markers of Long-Term Green Tea Polyphenol Intake in Humans. Y. Zhou, N. Zhang, A. Arikawa, C. Chen. University of Minnesota Twin Cities and University of North Florida. C292 II 646.6 The Effect of Daily Soy Isoflavone Supplementation for One Year on Endogenous Steroid Metabolism in Healthy Postmenopausal Women. L. Wang, N.W. Gaikwad, F.M. Steinberg. University of California at Davis. C293 I 646.7 Hypoglycaemic and Hypolipidemic Effect of Standardized Small Millet (Paspalum scrobiculatum, Panicum miliare, Setaria italica) Incorporated Cookies Fed Rats. K. Packiyam, M. Durairaj, V. Nachimuthu. Sethu Bhaskara Agricultural College and Research Foundation, India and Tamil Nadu Agricultural University, India.

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NUTRITION SUNDAY C294 II 646.8 Use of Spot Urine Caffeine and Caffeine Metabolite Concentrations for Distinguishing a Recommended Upper Limit of Caffeine Intake. M.E. Rybak, M.R. Sternberg, C. Pao. CDC. C295 I 646.9 Polyphenol Antioxidants Bind Irreversibly to Protein Under Oxidative Conditions. X. Sun, M.T. Engstrom, J. Salminen, A.E. Hagerman. Miami University and University of Turku, Finland. C296 II 646.10 The Synergistic Anti-Obesity Effect of Gelidium elegans Extract and Orlistat in Vivo and in Vitro. S. Choi, M. Park, J. Choi, E. Koh, Y. Seo, J. Song, S. Chei, J. Hwang, Y. Lee, B. Lee. CHA University, Republic of Korea. C297 I 646.11 Atorvastatin Decreases Menaquinone-4 Formation in C57Bl6 Male Mice. S.G. Harshman, M.K. Shea, X. Fu, D. Smith, M.A. Grusak, S. Lamon-Fava, A.S. Greenberg, A. Kuliopulos, S.L. Booth. Tufts University and USDA/ARS Children’s Nutrition Center. C298 II 646.12 Gut Microbiota Dictate Metabolic Fate of Curcumin in the Colon. Z. Li, Y. Sun, M. Song, F. Li, H. Xiao. University of Massachusetts Amherst. C299 I 646.13 Absorption and Metabolism of Isothiocyanates Formed from Broccoli Glucosinolates: Effects of Daily Consumption. C. Charron, B. Vinyard, S. Ross, H. Seifried, E. Jeffery, J. Novotny. U.S. Department of Agriculture, National Cancer Institute and University of Illinois. C300 II 646.14 Adaptation of Galloyl Derivatives Metabolism and Excretion After 42 Days of Mango (Mangifera indica L.) Consumption. S.U. Mertens-Talcott, H. Kim, S.T. Talcott, R. Barnes. Texas A&M University. C301 I 646.15 The Combined Application of the Caco2 Cell Bioassay Coupled with In Vivo (Gallus gallus) Feeding Trial Represents an Effective Approach to Predicting Fe Bioavailability in Humans. E. Tako, H. Bar, R.P. Glahn. USDAARS, Robert W. Holley Center for Agriculture and Health and University of Connecticut. C302 II 646.16 Fabrication of Lysozyme/Artemisia sphaerocephala Krasch Seed Polysaccharide Nanoparticles for the Encapsulation and Protection of Curcumin. D. Ren, J. Qi, A. Xie, X. Yang, H. Xiao. Shaanxi Normal University, People’s Republic of China, and University of Massachusetts. C303 I 646.17 Ingested Walnut Oil Can Prevent LowFat/High-Carbohydrate Diet and High-Fat Diet-Induced Obesity by Modulating Metabolic Health Markers and Regulating the Expression of Genes for Metabolism. V. Juturu, K. Sahin, C. Orhan, M. Tuzcu, N. Sahin. OmniActive Health Technologies Inc and Firat University, Turkey. C304 II 646.18 Dietary Mango Ginger May Enhance the Exercise Performance and Reduces Lipids When Combined with Treadmill Running: In Vivo Model. K. Sahin, M. Tuzcu, C. Orhan, N. Sahin, F. Akdemir, R. Pala, V. Juturu. Firat University, Turkey and OmniActive Health Technologies Inc. C305 I 646.19 Avenanthramides and Their Microbial Metabolites as the Urinary Exposure Markers for Whole Grain Oat Intake: A Kinetic Study in Human. S. Sang, P. Wang, A. Yerke. North Carolina A&T State University. C306 II 646.20 Metabolic Fate of Blueberry Anthocyanins After Chronic Supplementation in Healthy Older Adults. A. Sandhu, M.G. Miller, B. Shukitt-Hale, I. Edirisinghe, B. Burton-Freeman. Illinois Institute of Technology and USDA-ARS Human Nutrition Research Center on Aging at Tufts University.

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C307 I 646.21 Detection of Mature Plant miRNA in Different Biological Matrix: Importance of Internal Standard and Validation of the Method. H. Huang, J. Roh, C.D. Davis, T.T. Wang. USDA-ARS and NIH. C308 II 646.22 Targeting Inflammation and Synaptic Plasticity with Bioactive Polyphenol Metabolites Promotes Resilience Against Stress Disorder and Depression. G.M. Pasinetti. Icahn School of Medicine at Mount Sinai. C309 I 646.23 Role of Gut Microbiota-Derived Polyphenolic Acid in Attenuation of Protein Misfolding in Neurodegeneration. G.M. Pasinetti, L.M. Ho, J.M. Faith, K.M. Ono. Icahn School of Medicine at Mount Sinai. C310 II 646.24 Microbiome Analysis of the Refaunation of Donor Human Milk with Mom’s Own Milk. N. Harrison, N. Cacho, L. Carr, N. Li, L.A. Parker, J. Neu, G.L. Lorca. University of Florida. C311 I 646.25 Identification of Glycoproteins on the Surface of Bovine Milk Exosomes and Intestinal Cells That Facilitate Exosome Uptake in Human Colon Carcinoma Caco-2 Cells. S. Sukreet, H. Zhang, J. Adamec, J. Cui, J. Zempleni. University of Nebraska -Lincoln and University of Nebraska-Lincoln. C312 II 646.26 The Protective Effects of ProbioticFermented Soymilk on High-Fat Diet-Induced Hyperlipidemia. Y. Wang, C. Piao, J. Liu, H. Yu, W. Dai, X. Wang. Jilin Agricultrual University, People’s Republic of China, Jilin Agricultural University, People’s Republic of China. C313 I 646.27 Targeted Delivery of Resveratrol to Mouse White Adipose Tissue Using Adipose Stromal Cells (ASC) Targeted Nanoparticles. Y. Zu, S. Wang. Texas Tech University. C314 II 646.28 Change in Plasma Phospholipid Fatty Acids Over 13 Years and Determinants of Change: EPIC-Norfolk Study. F. Imamura, S.J. Sharp, Z. Ye, A. Koulman, J. Griffin, R. Luben, J. Zheng, K. Khaw, N.J. Wareham, N.G. Forouhi. MRC Epidemiology Unit, University of Cambridge, United Kingdom, MRC Elsie Widdowson Laboratory, United Kingdom, Department of Biochemistry, University of Cambridge, United Kingdom, Department of Public Health and Primary Care and University of Cambridge, United Kingdom. C315 I 646.29 In Silico Screening and Usability of Molecular Modeling in Finding Bio-Active Compounds in Diet Components: Investigation of Javamide-I/-II/-III and Chlorogenic Acids Found in Coffee and Flavonoids as p38 MAP Kinase Inhibitors. J. Park. BHNRC. C316 II 646.30 Synthetic Lethality of K-Ras Mutant Human Colorectal Cancer Cells by Phytochemical Curcumin and Fda-Approved Targeted Drug Regorafenib. C. Su, C. Wu. National Taiwan Normal University, Taiwan. C317 I 646.31 Comparative Effect of an AnthocyaninRich Extract from Purple Corn and Pure Anthocyanins on 3T3-L1 Adipocytes Under Different Physiological Conditions. D.A. Luna-Vital, M. Weiss, E. Gonzalez de Meija. University of Illinois. C318 II 646.32 Advanced Glycation End Products (AGEs) and sRAGE Levels After Benfotiamine Treatment in Diabetes Mellitus Type 2. C. Luevano Contreras, I. GuzmanRosiles, D. Del Castillo, A. Gomez-Ojeda, M. Garay-Sevilla. University of Guanajuato, Mexico and Spanish National Research Council, Spain.

SUNDAY NUTRITION C319 I 646.33 Phenolics from Wholegrain Oat Products as Modifiers of Starch Digestion and Intestinal Glucose Transport. M. Li, L. Hansen, K. Koecher, M.G. Ferruzzi. North Carolina State University, Purdue University and General Mills Inc. C320 II 646.34 Utilizing Phytonutrients for Public Health and Establishing Global Phytonutrient Society (GPS). H. Amagase, T. Miyazawa, K. Nakagawa, S. Kato. Amway Japan, Japan, Association of International Food and Nutrition, Japan, Global Phytonutrient Society, Japan and Tohoku University, Japan. C321 I 646.35 Dietary Delta-Tocotrienol Favors Abundance and Diversity of Beneficial Microbiomes in Obese Male Mice. C. Shen, R. Kottapalli, M.D. Tomison, I. Koboziev, C.R. Web, L. Ramalingam, N. Moustaid-Moussa, G. Kaur, J. Dufour, E. Chung, H. Mo, M.R. Grisham. Texas Tech University Health Sciences Center, Texas Tech University, University of Texas at San Antonio and Georgia State University. C322 II 646.36 A Combination of Herbal Extracts Targets Prostate Cancer by Upregulating AMPK Through the Tumor Suppressor Protein LKB1. A. MacDonald, D. Donohoe, A. Bettaieb, A. Han, Y. Zhao, J. Whelan. University of Tennessee. C323 I 646.37 Molecular Docking Study and Evaluation of the Anti-Diabetic Complications of Dihydroxanthyletin-Type Coumarins from Angelica decursiva. H. Jung, M.Y. Ali, S. Jannat, S.K. Park, J.S. Choi. Chonbuk National University, Republic of Korea, Pukyong National University, Republic of Korea. C324 II 646.38 Black Bean Coat Anthocyanin-Rich Extracts and Pure Anthocyanins Modulated Molecular Markers of Diabetes. L. Mojica, M. Berhow, E. Gonzalez de Mejia. Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. C, Mexico, University of Illinois, United States Department of Agriculture and Agricultural Research Service. C325 I 646.39 Role of Estrogen Receptor Alpha in Protective Effects of Soy in Adipose Tissue Following Ovariectomy. L.T. McCabe, T.M. Zidon, R.J. Welly, J.W. Porter, N.C. Winn, O.E. Stricklin, M.L. Gastecki, D.B. Lubahn, J. Padilla, V.J. Vieira-Potter. University of Missouri. C326 II 646.40 Protective Effect of Anthocyanin on Alcohol Induced Liver Fibrosis Is Due to the Regulation on AMPK/mTOR/Autophagy Pathway and Energy Status. L. Yang, T. Wan, S. Wang, M. Ye, L. Pei, R. Jiang, Y. Qiu. School of Public Health, Sun Yat-sen University, People’s Republic of China. C327 I 646.41 Strawberries Improve Pain Symptoms in Obese Participants with Radiographic Evidence of Knee Osteoarthritis. J. Schell, D. Christiansen, J. Barrett, E. Lohrman, N. Betts, Y.D. Zhao, J. James, H. Scofield, A. Basu. Oklahoma State University, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation. C328 II 646.42 Se-Allylselenocysteine Suppresses Inflammation via Inhibiting iNOS Expression. A. Cheng, M. Lee, M. Pan. Chang Jung Christian University, Taiwan and National Taiwan University, Taiwan. C329 I 646.43 Pterostilbene Inhibits Adipocyte Differentiation by Targeting CHOP10 in 3T3-L1. K. Kim, Y. Seo, E. Koh, J. Choi, J. Hwang, Y. Lee, J. Song, S. Chei, S. Choi, M. Park, B. Lee. CHA University, Republic of Korea.

C330 II 646.44 A Date Palm Extract Modulates Nuclear Receptor-Mediated Transactivation in Vitro. M. Ricketts, E. Alfaro-Viquez, J. Reed, C. Krueger, C. Rainey. University of Nevada Reno, University of Wisconsin-Madison, Complete Phytochemical Solutions and Date Research Institute. C331 I 646.45 Polyphenol-Rich Extract of Syzygium cumini Leaf Reduces Non-Alcoholic Fatty Liver Disease in MSG-Obese Mice by a Joint Action on Insulin Resistance and Endoplasmic Reticulum Stress. L.M. França, P.C. dos Santos, K.T. Flister, C.C. Vale, J.R. Sanches, R.A. Benevides, N.L. Xavier Ribeiro, F.M. Laurindo, A.d. Paes. Federal University of Maranhão, Brazil and University of São Paulo, Brazil. C332 II 646.46 Genistein and Daidzein Influence Lipid Metabolism in Human and Murine Cells via Liver X Receptor. T.F. Luo, N.F. Shay. Oregon State University. C333 I 646.47 Effects of Sulforaphane in the Tumor Microenvironment of Triple-Negative Breast Cancer. E. Slattery, T. Cline, L. Housley. California State University at Chico. C334 II 646.48 3R, 3′R Zeaxanthin Protects Retina from Photo-Oxidative Damage: in Vivo Model. N. Sahin, F. Akdemir, C. Orhan, M. Tuzcu, I. Yilmaz, V. Juturu. Firat University, Turkey, Inonu University, Turkey and OmniActive Health Technologies Inc. C335 I 646.49 Green Tea Extract Protects Against Hepatic NFκB Activation Along the Gut-Liver Axis in DietInduced Obese Mice with Nonalcoholic Steatohepatitis by Reducing Endotoxin and TLOR4/MyD88 Signaling. J. Li, C. Chitchumroonchokchai, J.B. Kim, G.Y. Sasaki, M.V. Moller, J.A. Bouranis, R.S. Bruno. The Ohio State University. C336 II 646.50 Chronic Effects of an Olive Leaf Extract on Sucrose Hydrolysis and Transport in the Caco-2/TC7 Model of the Small Intestine. A.H. Pyner, S. Tumova, S. Gardner, A. Kerimi, L. McKeown, G. Williamson. University of Leeds, United Kingdom. C337 I 646.51 Genistein in Combination with Sulforaphane for the Treatment of Type 2 Diabetes. D. Liu, A. Wang, J. Liu, H. Alkhalidy, W. Zhen, W. Moore. Virginia Tech. C338 II 646.52 Flavonol Kaempferol Improves Glucose Homeostasis via Suppressing Hepatic Glucose Production and Enhancing Insulin Sensitivity in Diabetic Mice. W. Moore, H. Alkhalidy, K. Zhou, D. Liu. Virginia Tech and Wayne State University. C339 I 646.53 Mechanisms Mediating Effects of Eicosapentaenoic Acid in Hepatic Steatosis in High Fat Fed Mice and in HepG2 Hepatoma Cells. S.M. Gonzalez, K.M. Albracht-Schulte, L. Ramalingam, N.S. Kalupahana, N. Moustaid-Moussa. Texas Tech University, University of Peradeniya and Sri Lanka, Sri Lanka. C340 II 646.54 25-Hydroxyvitamin D Elicits HormoneLike Response in Intestinal Epithelium. C. Reynolds, N. Koszewski, R. Horst, D. Beitz, J. Goff. Iowa State University and Heartland Assays. C341 I 646.55 Effect of Resveratrol in Methylation Promoter of FNDC5 Gene in Skeletal Muscle and Adipose Tissue. V. Heredia-Lugo, P. Garcia-Tobilla, M. Rodriguez, B. Palacios. Instituto Nacional de Medicina Genomica, Mexico.

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NUTRITION SUNDAY C342 II 646.56 The Effect of a High-Fat Diet and Green Tea Extract on Glucose Metabolism and Inflammation in Regulator of G Protein Signaling 10 Knockout Mice. H. Park, E. Olsen, X. Fang, J. Dagher, J. Chung, S. Kang, J. Lee. University of Georgia. C343 I 646.57 Effects of Dietary Pomegranate Extract and Inulin in Mice Fed an Obesogenic Diet. J. Yang, S. Zhang, S.M. Henning, R. Lee, M. Hsu, E. Grojean, R. Pisegna, A. Ly, D. Heber, Z. Li. University of California Los Angeles. C344 II 646.58 Bitter Receptors Control Glucose Absorption in the Gut by Modifying the G-Protein Coupled Receptor Signaling Cascade. K.M. Palatini ‘Jackson, T. Rathinasabapathy, S. Bonney, D. Esposito, S. Komarnytsky. North Carolina State University, Plants for Human Health Institute, North Carolina State University, International Medical University and School of Pharmacy, Malaysia. C345 I 646.59 Cornus officinalis Polyphenols Reduce Senescence of Vascular Cells by Modulating the Antioxidant Response. G. Salazar, H. Morgan, R.G. Feresin, D K.S. Klarich. Florida State University and University of Arkansas for Medical Sciences. C346 II 646.60 Plant Polyphenol Extract Regulated Diacylglycerol Acyltransferase and Tristetraprolin Gene Expression in Cultured Mouse Cells. H. Cao, K. Sethumadhavan, R. Anderson. USDA-ARS. C347 I 646.61 Blueberry Metabolites Restore Composition of Glycosaminoglycan Structures in Diabetic Human Vascular Endothelial Cells. B. Cutler, J. Chua, B. Kuberan, A. Pon Velayutham. University of Utah. C348 II 646.62 Muscadine Grape Extract Prevents Proliferation of HER2 Positive Breast Cancer Cells in Association with a Decrease in Phosphorylation of AKT and mTOR. J.D. Mackert, E. Tallant, P.E. Gallagher. Wake Forest School of Medicine. C349 I 646.63 Epigenetic Regulation of WNT and Hedgehog Oncogenic Signaling in Breast Cancer Cells in Response to Dietary Polyphenols. B. Stefanska, L. Kurzava, K. Lubecka, M. Beetch, K. Flower, J.M. Flanagan. Purdue University and Imperial College London, United Kingdom.

647. RESEARCH WITH DIETARY SUPPLEMENTS AND BIOACTIVE COMPONENTS Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C350 I 647.1 Dietary Supplement Use in All United States Military Services. J.J. Knapik, K.G. Austin, D.W. Trone, E.K. Farina, R.A. Steelman, H.R. Lieberman. US Army Research Institute of Environmental Medicine, US Army Public Health Command, Naval Health Research Center and US Army Public Health Center.

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C351 II 647.2 Moringa Leaf Powder Modulates Reverse Cholesterol Transport Without Changing Plasma Lipids in Guinea. G. Murillo, M. Almatrafi, M. VergaraJimenez, M. Fernandez. University of Connecticut, University of Costa Rica, Costa Rica and University of Sinaloa, Mexico. C352 I 647.3 Usual Intakes of Flavonoids: Estimates from What We Eat in America, NHANES 2007–2010. R.S. Sebastian, J.D. Goldman, C. Wilkinson Enns, A.J. Moshfegh. ARS and USDA. C353 II 647.4 The Iron Paradox: Discrepancies in Iron Chemical Forms Found in Prenatal Supplements and Tested in Clinical Trials. L. Saldanha, J. Dwyer, L. Brown, K. Andrews, P. Gusev, P. Pehrsson. Office of Dietary Supplements, NIH and Agricultural Research Service, USDA. C354 I 647.5 The Effect of Fish Oil Supplementation on Brain DHA and EPA Content and Fatty Acid Profile. K.J. Valentini, C.A. Pickens, J.A. Wiesinger, J.I. Fenton. Michigan State University. C355 II 647.6 Caffeine Intake Is Associated with Lifestyle Factors and Measures of Perceived Health in US Children: Findings from NHANES 2007–2012. N. Ahluwalia, S.M. Frenk. CDC, National Center for Health Statistics and Division of Health and Nutrition Examination Surveys. C356 I 647.7 Effects of Ginkgo Biloba Intake on Markers of Liver Function in a Large Representative Sample of the U.S. Population. S. Agarwal, H.R. Lieberman, V.L. Fulgoni; III. ORISE, U.S. Army Research Institute of Environmental Medicine and Henry M. Jackson Foundation. C357 II 647.8 A Comparison of Labeled Nutrients with Respect to Recommended Amounts in Toddler Dietary Supplements. L. Saldanha, L. Brown, C. Brasseux, R. Bailen, J. Dwyer, A. Ershow. ODS/NIH and Cornell University. C358 I 647.9 Impact of Walnut Supplementation on Dietary Change for Weight Loss. E. Neale, M. Batterham, L. Tapsell. University of Wollongong, Australia. C359 II 647.10 Hepatoprotective Effect of Centella asiatica Extract (ECa233) in Rotenone-Induced Liver Injury Rats. R.Tansawat,T. Intararuchikul, R. Rodsiri, K. Meksawan, W. Warisnoicharoen. Chulalongkorn University, Thailand. C360 I 647.11 Addition of a Snack of Lupinus mutabilis Sweet to the Conventional Treatment with Metformin in the Control of Type-2 Diabetes. M.E. Baldeon, M. Fornasini, A. Hidalgo, L. Masabanda, J. Castro, M. Tufiño, E. Villacrés. Universidad Tecnológica Equinoccial, Ecuador, Universidad de las Américas, Ecuador, Unidad Municipal de Salud Norte Patronato San José, Ecuador, Instituto Nacional Autónomo de Investigaciones Agropecuarias and INIAP, Ecuador. C361 II 647.12 Effect of Sulfur-Containing Compounds on Hydrogen Sulfide Production in THP-1 Differentiated Macrophages. C. Rodrigues, E. Fereyduni, A.J. Grenning, C.A. Rowe, S.S. Percival. University of Florida. C362 I 647.13 Dietary Supplement Items on Commonly Used Food Frequency Questionnaires. L. Rios-Avila, J. Dwyer, R. Costello, N. Potischman. National Institutes of Health.

SUNDAY NUTRITION C363 II 647.14 Analytically Predicted Estimates for Vitamin D, Vitamin a and Chromium Content in Adult Multivitamin/Mineral Products (MVMs) for the Dietary Supplement Ingredient Database (DSID). K.W. Andrews, P.A. Gusev, P.V. Dang, S. Savarala, L.Y. Oh, P.R. Pehrsson, J.T. Dwyer, J.M. Betz, R.B. Costello, L.G. Saldanha, L.W. Douglass. ARS-USDA, ODS-NIH and Consulting Statistician. C364 I 647.15 Do Single- And Multi-Ingredient Botanical Dietary Supplements Containing Green Tea Pass the United States Pharmacopeia’s (USP) Disintegration and Dissolution Requirements? P.A. Gusev, K.W. Andrews, S. Savarala, P.V. Dang, L.Y. Oh, P.R. Pehrsson, J.T. Dwyer, J.M. Betz, R.B. Costello, L.G. Saldanha, A.J. Kuszak. ARS-USDA and ODS-NIH. C365 II 647.16 Total Usual Intake of Most Shortfall Nutrients Varies with Poverty Among U.S. Adults. R.L. Bailey, S.R. Akabas, E.E. Paxon, S. Saklani, S.V. Thuppal, K.L. Tucker. Purdue University, Columbia University and University of Massachusetts Amherst.

648. ADVANCING NUTRITIONAL EPIDEMIOLOGY WITH PUBLIC USE AND COMMERCIAL DATA SETS Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C366 I 648.1 Time Trends and Patterns of Reported Egg Consumption in the U.S. by Sociodemographic Characteristics. L. Jahns, Z. Conrad, L.K. Johnson, J.N. Roemmich, W. Juan. USDA-ARS Grand Forks Human Nutrition Research Center and FDA Center for Food Safety and Applied Nutrition. C367 II 648.2 Snacking Trends in US Adults Over a 35 Year Period from 1977–2012. E. Dunford, B. Popkin. Carolina Population Center, The University of North Carolina at Chapel Hill and The George Institute for Global Health, Australia. C368 I 648.3 Impact of Usual Intake of Added Sugars on Nutrient Adequacy: NHANES 2009–2012. T. Nicklas. Baylor College of Medicine. C369 II 648.4 Association of Added Sugars Intake with Physiologic Parameters in Adults: NHANES 2001–2012. C.E. O’Neil, T.A. Nicklas, V.L. Fulgoni III. Louisiana State University, Baylor College of Medicine and Nutrition Impact. C370 I 648.5 American Adults Meeting the 2015– 2020 Dietary Guidelines for Americans Added Sugars Recommendation: WWEIA, NHANES 2011–12. S.A. Bowman. USDA and Agricultural Research Service. C371 II 648.6 Can De-Identified Electronic Health Records Be Used to Describe Nutrition-Related Outcomes in a Cohort of Adolescent Women Attending Primary Care Facilities? M. Mclean, C.S. Jiang, A. Cheng, D. Moftah, J. Breslow, P.R. Holt, J.N. Tobin. The New York Academy of Sciences, The Rockefeller University and The Clinical Directors Network.

C372 I 648.7 Prepregnancy Body Mass Index Is Positively Associated with Dietary Inflammatory Index and C-Reactive Protein Concentrations During Pregnancy. D. Shin, K. Lee, J. Hur, H. Chung, N. Shivappa, M.D. Wirth, J.R. Hébert. University of North Dakota, Michigan State University, Hoseo University, Republic of Korea, University of South Carolina, Connecting Health Innovations and LLC. C373 II 648.8 The Association Between Dietary Fiber Intake and CRP Levels, US Adults, 2007–2010. S.J. Nielsen, M. Trak-Fellermeier, K. Joshipura. University of Pittsburgh and University of Puerto Rico. C374 I 648.9 Exploring Diabetes Care-Related Outcomes in Arkansas Healthcare Systems for Young Old (Ages 65–74) and Old (Ages 75–84) Age Groups. D. Bauerlein, J. Phelps, T. Crook, R. Hakkak. University of Arkansas for Medical Sciences. C375 II 648.10 What Do People Eat When They Don’t Eat Meat? An Evaluation of Dietary Quality Using the National Health and Nutrition Examination Survey (NHANES), 2007–2012. Z. Conrad, M. Karlsen, K. Chui, L. Jahns. US Department of Agriculture, Agricultural Research Service, Friedman School of Nutrition Science and Policy, Tufts University, School of Medicine and Tufts University. C376 I 648.11 Combining National Food Consumption Survey Data with a Bioactive Database in a Probabilistic Intake Model to Assess Bioactive Intakes in Europe—A Tool Resulting from the European Bacchus Project. S. Pigat, F. Bompola, M. Cushen, J. Plumb, P. Finglas. Creme Global, Ireland and Institute of Food Research, United Kingdom. C377 II 648.12 Mixed Dishes Are a Top Contributor to Vitamin K Intake in US Adults: Data from the 2011–2012 NHANES. S.G. Harshman, E.G. Finnan, K. Barger, R.L. Bailey, D.B. Haytowitz, S.L. Booth. Tufts University, Purdue University and Beltsville-HNRCA. C378 I 648.13 Yogurt Consumption Is Associated with Improved Nutrient Intakes, Diet Quality, Body Weight and Cardiometabolic Biomarkers in the US: Results from NHANES 2011–14 and the Food Patterns Equivalent Database. B. Garcia-Bailo, N. Jain, J. Smith, V. Benoit. Bell Institute of Health and Nutrition, General Mills and Inc. C379 II 648.14 The Dairy Food Group Contributes Essential Nutrients to the Diets of Children and Adults. C.J. Cifelli, J.A. Houchins, E. Demmer, V.L. Fulgoni; III. National Dairy Council, Nutrition Impact and LLC. C380 I 648.15 Legume Consumption, Diet Quality and Body Weight: Results from NHANES 2009–2012 and the Food Patterns Equivalent Database 2009–2012. B. Garcia-Bailo, N. Jain, C. Keeler, J. Smith. Bell Institute of Health and Nutrition, General Mills and Inc. C381 II 648.16 Associations of Birth-Related Factors with Adult Weight Status and Blood Pressure: Findings from the Longitudinal Framingham Offspring Cohort. N. Parekh, Y. Lin, J.L. Freudenheim, A. Deierlein. New York University College of Global Public Health, New York University School of Medicine, Rutgers School of Public Health, Rutgers Cancer Institute of New Jersey and University of Buffalo. C382 I 648.17 The Role of Ready-To-Eat Cereal Fortification in Nutrient Intakes Among Children and Teens: A Modeling Study Using NHANES 2011–2012. J. Smith, B. Garcia-Bailo, N. Jain, L. Shiery, C. Gugger. Bell Institute of Health and Nutrition, General Mills and Inc.

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NUTRITION SUNDAY C383 II 648.18 Patterns of Ready-To-Eat Cereal Consumption and Nutrient Intakes Among Ready-to-Eat Cereal Eaters: Results from NHANES 2013–2014 J. Smith, B. Garcia-Bailo, V. Vanage, L. Shiery. General Mills, Inc., Bell Institute of Health and Nutrition, General Mills and Inc. C384 I 648.19 Nutrition, Health and Economic Development Nexus in Sub-Saharan Africa: Evidence from Vector Auto Regression Models. S.S. Klobodu, J. Dawson, D. Reed, C. Carpio, N. Moustaid-Moussa, N. Velikova. Texas Tech University. C385 II 648.20 Objectively Collected Weight Data and Long-Term Outcomes: Analysis of Data from 90,000 Users of the Withings Smart Scale. L.J. Wilkinson, D. Levitsky. University of Alabama, Birmingham and Cornell University. C386 I 648.21 Socioeconomic Disparities in the Prevalence of Coexistence of Metabolic Syndrome and Osteopenia Among Postmenopausal Women in South Korea: The 2008–2011 Korea National Health and Nutritional Examination (KNHANES). H. Lee, H. Lim. Kyung Hee University, Republic of Korea. C387 II 648.22 Environmental Exposure to Cadmium Is Decreasing Among Adults and Children in the US. T.M. Vance. SUNY College at Plattsburgh.

649. CHILDHOOD NUTRITION EPIDEMIOLOGY Poster (Sponsored by: Nutritional Epidemiology RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C388 I 649.1 Monetary Diet Cost Is Positively Associated with Diet Quality: Analysis of School-Aged Children in South China. J. Zhang, H. Xue, D. Li, J. Yin, Y. Chen, G. Cheng. West China School of Public Health, Sichuan University, People’s Republic of China. C389 II 649.2 High Protein Intake Along with Paternal Part-Time Employment Is Associated with Higher Body Fat Mass Among Girls from South China. J. Luo, Yang, H. Xue, J. Pan, L. Libuda, R. Muckelbauer, M. Yang, G. Cheng. Sichuan University, People’s Republic of China, University of Duisburg-Essen, Germany and Charité—Universitätsmedizin Berlin, Germany. C390 I 649.3 Consumption of Mixed Dishes by American Children and Adolescents: An Analysis Beyond Calories, Saturated Fat and Sodium. J.A. Houchins, C.J. Cifelli, E. Demmer, V.L. Fulgoni III. National Dairy Council, Nutrition Impact and LLC.

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C391 II 649.4 What Children Eat and Drink in America: Changes Between 2003–2004 and 2013–2014. D.G. Rhodes, J.C. Clemens, A.J. Moshfegh. Agricultural Research Service and Beltsville Human Nutrition Research Center. C392 I 649.5 Is Soy Isoflavones Consumption Associated with Pubertal Onset in Boys? G.S. Siapco, P. Pribis, J. Sabate. School of Public Health, Loma Linda University, College of Education and University of New Mexico. C393 II 649.6 Nutritional Status of Brazilian Children from Acre and Rio Grande Do Sul States Assisted by “Bolsa Família” Program. M.J. Bortolini, A.G. Freitas, D.G. Lima, C.F. Silva, C.S. Bortolini, L.C. Abreu, D.U. Meneguetti, R.P. Silva. Federal University of Acre, Brazil and Faculdade de Medicina do ABC, Brazil. C394 I 649.7 Preterm Birth and Biomarkers of Environmental Enteric Dysfunction Among Infants in Tanzania. E. Liu, K.P. Manji, C.M. McDonald, K. Gosselin, R. Kisenge, W.W. Fawzi, A.T. Gewirtz, C.P. Duggan. Boston Children’s Hospital, Muhimbili University of Health and Allied Science, Tanzania, Children’s Hospital Oakland Research Institute, Harvard School of Public Health and Georgia State University. C395 II 649.8 Egg Consumption Is Associated with Greater Intake of Several Nutrients to Encourage, Lower Total and Added Sugar Intake and Improved Recumbent Length in Us Infants: Data from the National Health and Nutrition Examination Survey, 2001–2012. Y. Papanikolaou, V.L. Fulgoni. Nutritional Strategies, Canada and Nutrition Impact. C396 I 649.9 Dyslipidemia Among School-Age Children and Adolescents in Southern Provinces of China. J. Shi, L. Liu, H. Li, S. Du. Beijing Municial Center for Disease Control and Prevention, People’s Republic of China, and The University of North Carolina at Chapel Hill. C397 II 649.10 Pasta Consumption in American Children and Adolescents Is Associated with Greater Daily Intake of Shortfall Nutrients as Defined by the 2015–2020 Dietary Guidelines, Improved Diet Quality and Lower Added Sugar Intake. Y. Papanikolaou. Nutritional Strategies, Canada. C398 I 649.11 Egg Consumption Is Associated with Greater Intake of Several Nutrients to Encourage and Lower Total and Added Sugar in US Children and Adolescents. Y. Papanikolaou, V.L. Fulgoni. Nutritional Strategies, Canada and Nutrition Impact. C399 II 649.12 Blood Lead, Iron Deficiency and Attentional ADHD Symptoms in Uruguayan First-Graders. G. Barg, E.I. Queirolo, N. Mañay, F. Peregalli, K. Kordas. Catholic University of Uruguay, Uruguay, University of the Republic of Uruguay, Uruguay and University at Buffalo. C400 I 649.13 Relationship of Stunting and Overweight in Egyptian Children Under Five Years of Age: Trends and Associated Risk Factors. S. Ghosh, G. Namirembe, M. Moaz, A. Pokharel, E. Marino-Costello, J.K. Griffiths, P. Webb. Tufts and Helen Keller International, Nepal.

SUNDAY NUTRITION

650. LACTATION Poster Maternal, Perinatal and Pediatric Nutrition RIS Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C401 I 650.1 Adequacy and Sources of Total Daily Water and Liquid Drinks by Low-Income, Urban and Rural, Pregnant and Lactating Women in the Western Highlands of Guatemala. L.A. Diaz-Jereda, G. Montenegro-Bethancourt, M. Vossenaar, N.W. Solomons. CeSSIAM, Guatemala. C402 II 650.2 Comparative Evaluation of the Performance of Urinary Biomarkers of Hydration Status Among Lactating Women in the Western Highlands of Guatemala. H.B. Rolker, A. Maldonado, M. Soto-Méndez, A.B. MelseBoonstra, N.W. Solomons. Wageningen University, Netherlands and CeSSIAM, Guatemala. C403 I 650.3 Maternal Low-Protein Diet During Gestation Gender-Selectively Induces Amino Acid Response Pathway and Autophagy in the Liver of Offspring Rats. M. Cai, H. Wang, Y. Pan. University of Illinois at Urbana-Champaign. C404 II 650.4 Acceptability to Consumers of a Whey-Protein Concentrate Supplement When Added to Assorted, Customary Thin Gruels (Atoles) of Guatemala. M.L. Escobar, C.L. Arriaga, A. Maldonado, D. Fuentes, E. Diaz-Ruiz, R. García-Meza, M. Vossenaar, N.W. Solomons, D. Hirst, M.J. Bonorden. CeSSIAM, Guatemala and Hormel Foods Company. C405 II 650.5 Body Composition in Mothers of Infants According to the Type of Feeding. Preliminary Data. E. GuzmánMercado, E.M. Vasquez-Garibay, A. Larrosa-Haro, N. MuñozEsparza, N. Badillo, S. Apodaca, M. Mancilla-Madrid, E. Romero-Velarde. University of Guadalajara, Mexico. C406 II 650.6 Impact of Maternal Diet and Exercise on Human Milk Insulin. C. Burchenal, L. Barbour, T. Hernandez, J. Friedman, N. Krebs, B. Young. University of Colorado. C407 I 650.7 Quantity and Species of Fish Consumed Shapes Breast Milk Fatty Acid Concentrations Around Lake Victoria, Kenya. K.J. Fiorella, E.M. Milner, D.O. Omollo, M.D. Hickey, C. Salmen, E. Bukusi, L.C. Fernald. Cornell University, University of California, Berkeley, Organic Health Response-Ekialo Kiona Center, Kenya, University of California, San Francisco, University of Minnesota and Kenya Medical Research Institute, Kenya. C408 II 650.8 BMI-Based Prenatal Vitamins in Obese Pregnancy: Cohort Profile. S. Sen, A. Penfield-Cyr, C. Benjamin, M. Tynan, M. Herlihy, M. Hacker, T. McElrath. Brigham and Women’s Hospital, University of Rhode Island and Beth Israel Deaconess Medical Center. C409 I 650.9 Milk Production in Mothers with and Without Signs of Insulin Resistance. L.A. Nommsen-Rivers, S.A. Riddle, A. Thompson, L. Ward, E. Wagner. University of Cincinnati and Cincinnati Children’s Hospital.

C410 II 650.10 Associations Between Breastfeeding Intention and Accurate Body Size Estimation Among Female College Students. K.D. Powell, S. Colby, M.D. Olfert, W. Zhou, M. Spence, C. Springer, K. Kavanagh. University of Tennessee and West Virginia University. C411 II 650.11 Breastfeeding Knowledge, Attitudes, Prior Exposure and Intention of a Sample of Undergraduate Students in Honduras. M. Rendon, Z. Lou, M.L. Spence, M. Mejia, S.E. Colby, K.F. Kavanagh. University of Tennessee. C412 I 650.12 Pumping on Campus: Validity and Reliability of a Theory-Based Instrument to Assess Breastfeeding Behavior. L.M. Dinour, Y.K. Bai. Montclair State University. C413 I 650.13 Patterns of Breastfeeding at 3 Months Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study. M. Jarman, P.J. Robson, Y. Shen, M. Madsen, R.C. Bell, A. Study Team, E. Team. University of Alberta, Canada and Alberta Health Services, Canada. C414 II 650.14 The Relationships Between Maternity Practices and Exclusive Breastfeeding Rates in the Hospital. J.A. Patterson, N.S. Keuler, B.H. Olson. University of Wisconsin- Madison. C415 I 650.15 Peripheral Serotonin Deficiency May Assist Early Lactation Outcomes in Mice Fed a High-Fat Diet. A.A. Cheng, L.L. Hernandez. University of Wisconsin-Madison. C416 II 650.16 Disparities in Breastfeeding Outcomes Between Women Undergoing Medication-Assisted Treatment (MAT) for Substance Use Disorder (SUD) and Abstaining Controls. E.Y. Jimenez, N. Yonke, L.M. Leeman, S. Shrestha, S. Cano, L. Garrison, S. Williams, J. Stephen, L. Bakhireva. University of New Mexico and Mind Research Network. C417 I 650.17 An Assessment of the Social Cognitive Predictors of Exclusive Breastfeeding Behavior Using the Health Action Process Approach. J.L. Martinez-Brockman, F. Shebl, N. Harari, R. Perez-Escamilla. Yale University and Indian Health Service. C418 II 650.18 Lactation Advice Through Texting Can Help (LATCH): An Analysis of Intensity of Engagement via TwoWay Text Messaging. J.L. Martinez-Brockman, N. Harari, R. Perez-Escamilla. Yale University and Indian Health Service. C419 I 650.19 Optimal Time to Initiate Breast Milk Expression in Mothers Delivering Extremely Premature Infants. L. Parker, M. Mueller, S. Sandra, C. Krueger. University of Florida and Medical University of South Carolina. C420 I 650.20 Maternal Weight Over Successive Pregnancies and Breastfeeding Initiation, Duration and Exclusivity. E. Metallinos-Katsaras, E.C. Siu, R. Colchamiro. Simmons College and Massachusetts Department of Public Health. C421 I 650.21 Trends in Breastfeeding in the State of Georgia, 2004–2013. A.K. Anderson, F.A. Kanu, M. Mwaura, T.S. Ward. The University of Georgia. C422 I 650.22 Early-Life Prebiotics Alter Exploratory Behavior, Recognition Memory, and Brain Serotonin in the Neonatal Piglet. S.A. Fleming, S. Monaikul, A.J. Patsavas, B.M. Berg, R.V. Waworuntu, R.N. Dilger. University of Illinois and Mead Johnson Pediatric Nutrition Institute.

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NUTRITION SUNDAY C423 II 650.23 The Impact of Gestational Endocrine Disorders of Breast Milk Fat Characteristics and Infant Growth. L. Ellsworth, E. Harman, C. Anderson, A. Craig, E. John, J. Yeh, B. Gregg. University of Michigan. C424 I 650.24 Antimicrobial Peptides in Human Milk. L. Filgueira, G.K. Kueffer, A. Twigger, M. Walch, D.T. Geddes. University of Fribourg, Switzerland and University of Western Australia, Australia. C425 II 650.25 Serum Concentration of Appetite Regulating Hormones in Infants According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. LarrosaHaro, S. García-Arellano, N. Muñoz-Esparza, E. GuzmánMercado, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C426 I 650.26 Serum Concentration of Appetite Regulating Hormones in Nursing Mothers According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, N. Muñoz-Esparza, E. Guzmán-Mercado, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C427 II 650.27 Comparison of the Serum Concentration of Appetite Regulating Hormones in the Mother-Child Dyad According to the Type of Feeding. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, E. Guzmán-Mercado, N. Muñoz-Esparza, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C428 I 650.28 Concentration of Ghrelin and Leptin in Human Serum and Human Milk in Exclusively Breastfeeding Nursing Mothers. Preliminary Data. E.M. Vasquez-Garibay, A. Larrosa-Haro, S. García-Arellano, E. Guzmán-Mercado, N. Muñoz-Esparza, F. Muñoz-Valle, E. Romero-Velarde. University of Guadalajara, Mexico. C429 II 650.29 Evaluation of Three Doses of Dietary Sialyllactose on Growth and Intestinal Development in the Neonatal Piglet. M.H. Monaco, M. Wang, X. Pan, Q. Li, J.D. Richards, M. Chichlowski, B. Berg, R.N. Dilger, S.M. Donovan. University of Illinois and Mead Johnson Pediatric Nutrition Institute. C430 I 650.30 Using Metatranscriptomics to Determine Effects of Dietary Supplementation with Bovine Milk Oligosaccharides in Healthy Adults. S.T. Westreich, D. Barile, J. Salcedo, D.A. Mills, J.T. Smilowitz, I. Korf, D.G. Lemay. University of California, Davis and USDA ARS Western Human Nutrition Research Center. C431 II 650.31 Human Milk Adipokines and Macronutrients and Infant Body Composition in the First Year of Life. D. Geddes, Z. Gridneva, S. Kugananthan, A. Hepworth, L. Ward, W. Tie, C. Lai, P. Hartmann. The University of Western Australia, Australia and The University of Queensland, Australia.

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C432 I 650.32 Maternal Body Mass Index and Presence of Appetite Regulating Hormones and Other Factors in Human Breast Milk. W.A. Clark, M.R. Kwon, E.M. Cress, R.C. Hamdy, H. Cobarrubias, S. Luttrell, W.L. Stone, M. Brannon, J.M. Peterson. East Tennessee State University. C433 I 650.33 Stem-Like Cells in Breastmilk for Hospitalized Preterm Infants. C. Briere, T. Jensen, J.M. McGrath, C. Finck. Connecticut Children’s Medical Center, University of Connecticut and University of Connecticut Health Center. C434 II 650.34 Maternal BMI Is Correlated with NonFasting Human Milk Insulin, but Not Macronutrients. M.L. Sarangam, B. Young, A.L. Garces, L. Figueroa, G. Tejada, J. Kemp, J.L. Westcott, M. Hambidge, N. Krebs. University of Colorado School of Medicine and Institute of Nutrition of Central America and Panama, Guatemala. C435 I 650.35 Protein Intake from Dairy Food Increases Bovine Beta-Casomorphin 7 in Human Mature Milk. J. Flores Alvarado, L. Oropeza Ceja, D. Ronquillo, O. García, G. Martinez, M. Caamaño, C. García Ugalde, M. DuarteVázquez, J. Rosado. Universidad Autonoma de Queretaro, Mexico, Universidad Autonoma de Queret, Mexico, Cindetec and A.C., Mexico. C436 II 650.36 Maternal Factors and Human Milk Oligosaccharide Composition in the CHILD Cohort. B. Robertson, L. Bode, A.K. Sharma, A.B. Becker, P.J. Mandhane, P. Subbarao, S.E. Turvey, D.L. Lefebvre, M.R. Sears, M.B. Azad. University of California San Diego, University of Manitoba, Canada, Children’s Hospital Research Institute of Manitoba, Canada, University of Alberta, Canada, University of Toronto, Canada, University of British Columbia, Canada and McMaster University, Canada. C437 I 650.37 Investigating Methods of Estimating the Rate of Synthesis of Breast Milk and Milk Fat. D.T. Geddes, H. Gardner, C. Lai, P.E. Hartmann, J.C. Kent. The University of Western Australia, Australia. C438 I 650.38 Serum Lipid Profile in Nursing Mothers According to the Type of Feeding: Preliminary Data. E. Romero Velarde, E.M. Vasquez Garibay, A. Larrosa Haro, E. Guzmán Mercado, N.C. Muñoz Esparza, P. Ascencio Esparza. Hospital Civil de Guadalajara, Mexico and Universidad de Guadalajara, Mexico.

SUNDAY NUTRITION

651. FACTORS INFLUENCING LONG-TERM ECONOMIC/ENVIRONMENTAL SUSTAINABILITY OF THE FOOD SUPPLY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C439 I 651.1 A Western Dietary Pattern Has the Highest Environmental Footprints Among Lebanese Adults: Findings from a Cross Sectional Study Among Lebanese Adults. F. Naja, L. Jomaa, L. Itani, J. Zidek, N. Hwalla. American University of Beirut, Lebanon and Beirut Arab University, Lebanon. C440 II 651.2 Environmental Impacts of Typical Dietary Patterns in India. R. Green, E.J. Joy, J. Milner, S.H. Vetter, F. Harris, S. Agrawal, L. Aleksandrowicz, J.I. Macdiarmid, H.G. Jon, P.H. Smith, A. Haines, A.D. Dangour. London School of Hygiene and Tropical Medicine, United Kingdom, University of Aberdeen, United Kingdom and Public Health Foundation of India, India. C441 I 651.3 The Capacity of the Us Food System to Accommodate Improved Diet Quality: Projections to 2030. Z. Conrad, C. Peters, L.K. Johnson, L. Jahns. US Department of Agriculture, Agricultural Research Service, Friedman School of Nutrition Science and Policy and Tufts University. C442 II 651.4 “You Take the Cash Meant for Beans and You Buy Water”: The Multi-Faceted Consequences of Water Insecurity for Pregnant and Postpartum Kenyan Women of Mixed HIV Status. S.M. Collins, J.D. Miller, P. Mbullo, G.O. Boateng, P. Wekesa, M. Onono, S.L. Young. Northwestern University, Cornell University, Maseno University, Kenya and Kenya Medical Research Institute, Kenya. C443 I 651.5 A Meatless Monday Evaluation and Best Practices Guide for Reducing Meat Consumption in Food Service Institutions: A Qualitative Study. M. Chan, R. Ramsing. Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Center for Livable Future and Johns Hopkins Bloomberg School of Public Health. C444 II 651.6 Estimating Nutrient Losses from Wasted Food in the United States Food Supply. M.L. Spiker, H.A. Hiza, S.M. Siddiqi, R.A. Neff. Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Center for a Livable Future and USDA Center for Nutrition Policy and Promotion. C445 I 651.7 Withdrawn. C446 II 651.8 Demographics, Anthropometric Measurements, Vegetable Consumption, and Food Waste of Community Supported Agriculture (CSA) Members in Central Minnesota. E. Heying, K. Butkowski. College of Saint Benedict.

652. PROTEIN METABOLISM, INTAKE AND HEALTH IMPLICATIONS Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C447 I 652.1 Reduced Citrulline Flux and Concentration in Patients with Ketosis-Prone Diabetes Compared to Healthy Controls and Typical Type 2 Diabetes Suggest Impaired Gut Function. J.W. Hsu, S.N. Mulukutla, K.M. Bohren, A. Balasubramanyam, F. Jahoor. USDA/ ARS Children’s Nutrition Research Center, Baylor College of Medicine and Baylor College of Medicine. C448 II 652.2 Sustained Postprandial Muscle Protein Synthesis Rates After Protein Ingestion in Healthy Young Males. N.A. Burd, S. van Vliet, L.J. van Loon, J.W. Beals, S.A. Paluska. University of Illinois at Urbana-Champaign and Maastricht University, Netherlands. C449 I 652.3 Dietary Leucine Supplementation Alters Muscle and Liver Protein Synthesis During Immune System Stimulation in Pigs. M. Rudar, L. Huber, C.L. Zhu, C.F. de Lange. University of Guelph, Canada. C450 II 652.4 Post-Exercise Consumption of Whole Eggs or Egg Whites Improves Whole Body Leucine Balance but Does Not Differentially Modulate Leucine Kinetics in Resistance-Trained Young Men. I.G. Martinez, S. van Vliet, E.L. Shy, J.W. Beals, A.V. Ulanov, M. Orlando, D.W. West, D.R. Moore, S.A. Paluska, N.A. Burd. University of Illinois at Urbana—Champaign and University of Toronto, Canada. C451 I 652.5 Analyzing Short Term Protein Oxidation Provides Evidence About Its Role in Whole Body Protein Metabolism. G. Reckman, M. Priebe, M. Koehorst, T. Boer, R.J. Vonk. UMCG, Netherlands. C452 II 652.6 Lack of Arginase II Spares Arginine and Restores Growth in Mice. J.C. Marini, M.A. Mohammad, I.C. Didelija. Baylor College of Medicine. C453 I 652.7 Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study. J. Marini, U. Agarwal, I.C. Didelija, M.S. Azamian, B. Stoll, S.C. Nagamani. Baylor College of Medicine. C454 II 652.8 Regulation of Leucine-Induced mTORC1 Activation in Skeletal Muscle of Neonatal Pigs. A. Suryawan, H.V. Nguyen, R.D. Parada, T.A. Davis. USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics and Baylor College of Medicine. C455 I 652.9 The Potential of Leucine to Regulate Skeletal Muscle Energy Metabolism Under Obesogenic Conditions. J.I. Baum, T.G. Inman, S.A. Shouse. University of Arkansas.

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NUTRITION SUNDAY C456 II 652.10 Whole Body Net Protein Balance Plateaus in Response to Varying Protein Intakes During PostExercise Recovery: Identification of a Maximal Anabolic Intake. M. Mazzulla, H. Kato, J. Packer, D. Wooding, D. Moore. University of Toronto, Canada, Ajinomoto Co. and Inc., Japan. C457 I 652.11 Variable Intensity Exercise Increases Protein Requirements in Active Male and Female Adolescents as Determined by the Indicator Amino Acid Oxidation (IAAO) Technique. J.C. Brooks, K.A. Volterman, D.W. West, G. Courtney-Martin, P.B. Pencharz, D.R. Moore. University of Toronto, Canada and The Hospital for Sick Children, Canada. C458 II 652.12 ncrease in FGF21 Stimulates Browning Markers in White Adipose Tissue in Rats Fed a Low Protein High Carbohydrate Diet During Acute Cold Exposure. G. Alemán, A. Vigil-Martínez, A.L. Castro, I. Flores-Galicia, I. Torre-Villalvazo, A. Díaz-Villaseñor, L.A. VelázquezVillegas, L.G. Noriega, P. López-Romero, D.C. GonzálezHirschfeld, G. Ordaz, O. Granados, N. Torres, A.R. Tovar. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Instituto de Investigaciones Biomédicas and UNAM, Mexico. C459 I 652.13 Dietary Protein Sources Beyond Proteins and Amino Acids—A Comparative Study of the Small Molecular Weight Components of Meat and Fish Using Metabolomics. A. Ross, A. Vincent, O.I. Savolainen, A. Sandberg, I. Undeland. Chalmers University of Technology, Sweden. C460 II 652.14 Crosstalk Between Lactobacillus reuteri and Mammalian Intestinal Epithelium. B.P. Gsnesh, A. Hall, S. Ayyaswamy, R. Fultz, J. Versalovic. Baylor College of Medicine. C461 I 652.15 Sex Differences in Snack Food Reinforcement in Response to Increasing Dietary Protein. S.L. Casperson, L. Johnson, J.N. Roemmich. USDA/ARS. C462 II 652.16 Lengths of Stunted Children Are Severely Compromised, but Breadths—Not So Much: Disproportions in the Anthropometric Deficits in So-Called “Chronic Malnutrition”. K. Shiu, N.W. Solomons, W.M. Liem, R. García-Meza. CeSSIAM, Guatemala. C463 I 652.17 Habitual Use of Flavored Commercial Products for Thin Gruel Beverage Preparation and the Acceptability of Their Fortification with Whey Protein Concentration Among Low-Income Women in the Central Highlands of Guatemala. A. Platte, M. Vossenaar, A. Zamora, C.L. Arriaga, N.W. Solomons, D. Hirst, M.J. Bonorden. CeSSIAM, Guatemala and Hormel Foods Company. C464 II 652.18 Effects of Consuming Different Protein Preloads on Appetite, Satiety, and Subsequent Food Intake. S.M. Douglas, J.A. Gwin, H.J. Leidy. Purdue University. C465 I 652.19 Body Fat Changes in the Beef WISE Study: Beef’s Role in Weight Improvement, Satisfaction, and Energy. R.D. Sayer, K.J. Speaker, Z. Pan, J.C. Peters, H.J. Wyatt, J.O. Hill. University of Colorado Anschutz Medical Campus.

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C466 II 652.20 Whey Protein Protects Muscle Mass Loss of Older Adults During 7 Days of Inactivity and Accelerates Recovery of Aerobic Fitness During Rehabilitation. E.J. Arentson-Lantz, E. Galvan, A. Wacher, D. Paddon-Jones. University of Texas Medical Branch. C467 I 652.21 Animal and Plant Proteins Impact Risk of Type 2 Diabetes Mellitus in the Framingham Study. L. Lara Castor, M. Bradlee, M.R. Singer, L.L. Moore. Boston University.

653. LIPID AND FATTY ACID METABOLISM AND TRANSPORT Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C468 I 653.1 Differences in the Enterocyte Cytoplasmic Lipid Droplet Proteome in Mice Resistant (Acyl CoA: Diacylglycerol Acyltransferase 1 Deficient) Versus Susceptible to Diet-Induced Obesity. A. Carreiro, K.K. Buhman. Purdue University. C469 II 653.2 Effects of Medium Chain Fatty Acid on the Expression of the Genes Related with Glycolytic and Fatty Acid Synthetic Pathways in the Mice Refed After Starvation. S. Takami, K. Matsumoto, K. Honma, K. Mochizuki, T. Goda. University of Shizuoka, Japan and University of Yamanashi, Japan. C470 I 653.3 cAMP-Dependent and Independent Mitigation of mTORC1-Driven Lipogenesis by Short-Chain Fatty Acids, R-α-Lipoic Acid and 4-Phenylbutyric Acid. R. Moreau, B. He. University of Nebraska—Lincoln. C471 II 653.4 The Role of FADS1 and FADS2 Genes in Oleic Acid (18:1n-9) Metabolism: FADS1 Δ7-Desaturates Gondoic Acid (20:1n-9, 11-20:1) to 7,11-20:2. H. Park, M.G. Engel, K. Vogt-Lowell, P. Lawrence, K. Kothapalli, J.T. Brenna. Cornell University. C472 I 653.5 A Need to Analyze Radiolabeled Cholesteryl Ethers for Biological Stability Before Use. D. Kollareth Manual, I.H. Hansen, R.J. Deckelbaum. College of Physicians and Surgeons and Columbia University Medical Center. C473 II 653.6 Short Term Fast Food and Mediterranean Diet Are Able to Change the HDL Lipidome with Different Patterns. C. Zhu, L. Sawrey-Kubicek, E. Beals, R.L. Hughes, C.H. Rhodes, R. Sacchi, A.M. Zivkovic. University of California Davis.

SUNDAY NUTRITION C474 I 653.7 Locating Apolipoprotein A2 Protein in the Central Nervous System. S. Azzam, J. Gamble, M. Decker, X. Li, Y. Hernandez, K.P. Strohl. Case Western Reserve University and Louis Stokes Cleveland VA Medical Center. C475 II 653.8 Branched Chain Fatty Acids Content of Natto. D. Wang, Y. Yang, P. Lawrence, J. Brenna. Cornell University. C476 I 653.9 How Does DHA Reach the Brain to Provide Neuroprotection After Hypoxic-Ischemic Injury? D. Kollareth Manual, H. Zirpoli, V. Ten, R.J. Deckelbaum. College of Physicians and Surgeons and Columbia University Medical Center. C477 II 653.10 Effects of Dietary Anaplerotic Carbon Sources and Ketogenic Fatty Acids on Hepatic Fatty Acid Oxidation in Neonatal Pigs. J. Zhao, B. Pike, Y. Zhang, S. Sabin, A. Smith, Y. Zhu, J. Odle, L. Xi. NCSU. C478 I 653.11 HDL-Associated Proteins and LDL Differentially Modulate Chronic Myelogenous Leukemia Cell Viability. C.J. Andersen, K. Murray, N. Ragonesi, A. Doerr, L. Cintron-Rivera, L. Dupree. Fairfield University.

654. ENERGY AND MACRONUTRIENT METABOLISM AND THE GUT Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C479 I 654.1 Neonatal Diet Composition Modulates Ileum Mitochondrial Function in a Neonatal Pig Model. E. Carvalho, A.R. Moreira, A.K. Bowlin, M.K. Saraf, S.H. Adams, E. Borsheim, L. Yeruva. Center for Neurosciences and Cell Biology, University of Coimbra, Portugal, Arkansas Children’s Nutrition Center, UAMS and Arkansas Children’s Research Institute. C480 II 654.2 Stimulation to the Oral Cavity Increase Splanchnic Circulation and Diet-Induced Thermogenesis After Drink Intake. Y. Hamada, N. Hayashi. Tokyo Institute of Technology, Japan. C481 I 654.3 Gut Microbiota Increased by Omega-3 Fatty Acids Is Negatively Correlated with Hepatic Lipid Metabolism-Associated Genes in Mice with High Carbohydrate Diet-Induced Steatosi. K. Huang, R.G. Nichols, A. Sebastian, I. Albert, A.D. Patterson, A. Ross. The Pennsylvania State University. C482 II 654.4 Effect of Medium Chain Triglycerides on TCA and Ketogenic Capacity of Proximal Intestinal Fatty Acid Oxidation in Clofibrate Feed Newborn Pigs. B.E. Pike, J. Zhao, J. Hicks, Y. Zhang, A. Smith, H. Liu, J. Odle, L. Xi. NCSU. C483 I 654.5 Dietary Fiber’s Contribution to the Energy Needs of the Microbiota. D.T. Gordon, D.J. Baer, V. Mai. NDSU, ARS, USDA and University of Florida.

655. METABOLIC PHENOTYPING, METABOLOMICS AND BIOMARKERS Poster (Sponsored by: Energy and Macronutrient Metabolism RIS) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–1:45 pm (I) 1:45 pm–2:45 pm (II) C484 I 655.1 Plasma Metabolome, PON1 Status, Environmental Exposures and Childhood Autism. J. Sotelo, I. Hertz-Picciotto, C. Slupsky. University of California at Davis. C485 II 655.2 Glycovariations in Key HDL-Associated Glycoproteins Differentiate Between Clinical Groups and Affect the Immunomodulatory Capacity of HDL. A.M. Zivkovic, S. Krishnan, M. Shimoda, R. Sacchi, J.K. Muchena, G. Luxardi, G.A. Kaysen, A.N. Parikh, V. Ngassam, K. Johansen, G. Chertow, B. Grimes, J.T. Smilowitz, E. Maverakis, C.B. Lebrilla. UC Davis, UC San Francisco and Stanford University. C486 I 655.3 Metabolism of Beta-Alanine in Rat Liver: Degradation to Acetyl-CoA and Carboxylation to 2-(Aminomethyl)-Malonate. K. Wilson, J. Hess, G. Zhang, H. Brunengraber, G. Tochtrop. Case Western Reserve University and Duke University. C487 II 655.4 Biomarkers of Food Intake and Nutrient Status Are Associated with Glucose Tolerance Status and Development of Type 2 Diabetes. O. Savolainen, M. Vendelbo Lind, G. Bergström, B. Fagerberg, A. Sandberg, A. Ross. Chalmers University of Technology, Sweden, University of Copenhagen, Denmark and Sahlgrenska Academy, Sweden. C488 I 655.5 Untargeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism in β, β-Carotene-9′, 10′-Oxygenase 2 Knockout Mice. Y. Lyu, L. Wu, X. Guo, A. Davis, S. Clarke, E. Lucas, B. Smith, W. Wang, D.M. Medeiros, X. Shen, D. Lin. Nanjing University of Finance and Economics, People’s Republic of China, Oklahoma State University, Kansas State University and University of MissouriKansas City. C489 II 655.6 Lipidomic Profiling of Erythocytes in Septic Patients Revels Novel Biomarkers. G.C. Mecatti, M.F. Messias, C.F. Angolini, P.O. de Oliveira Carvalho. Sao Francisco University, Brazil and University of Campinas, Brazil. C490 I 655.7 Metabolic Pathway Analysis of Biochanin A Administration on Obesity-Induced Metabolic Dysfunction. M. Hong, H. Park, S. Kim, N. Jeong, M. Kim. Korea Food Research Institute, Republic of Korea, and Korea University of Science and Technology, Republic of Korea. C491 II 655.8 Urinary Enterolignan-Associated Changes in Plasma Metabolites. F. Miles, S. Navarro, Y. Schwarz, T. Randolph, M. Neuhouser, A. Shojaie, H. Gu, D. Djukovic, M. Kratz, M. Hullar, P. Lampe, D. Raftery, J. Lampe. Fred Hutchinson Cancer Research Center, University of Washington, University of Washington and Northwest Metabolomics Research Center.

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Pathology 656. RESPIRATORY PATHOPHYSIOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Pulmonary Pathobiology Presentation time: 11:45 am–1:45 pm A1 656.1 Abrogation of RAGE Signaling Using SemiSynthetic Glycosaminoglycan Ethers (SAGEs) Ameliorates Inflammation in Mice Exposed to Secondhand Tobacco Smoke. K.M. Hirschi, J.B. Lewis, P.D. Hall, T.J. Wright, K.M. Egbert, K.C. Ogden, S.M. Nelson, J.C. Clark, D.C. Milner, J.A. Arroyo, P.R. Reynolds. Brigham Young University. A2 656.2 Phospholipase D Regulates GSK3β mediated Epithelial to Mesenchymal Transition and Akt Mediated Cell Death Leading to Pulmonary Fibrosis. V. Suryadevara, T.J. Royston, V. Natarajan. University of Illinois. A3 656.3 Non-Pungent Long Chain Capsaicin-Analogs Arvanil and Olvanil Display Better Anti-Invasive Activity Than Capsaicin in Human Small Cell Lung Cancers. K.W. Colclough, J. Seidler, A.T. Akers, J.D. Hurley, K.C. Brown, N.A. Nolan, P. Dasgupta. Marshall University, Joan C. Edwards School of Medicine and Marshall University. A4 656.4 Disease Specific Signatures Identified by RNA-Seq of Sorted Lung Cellular Populations. P.A. Reyfman, L. Morales-Nebreda, J.M. Walter, A. McQuattie-Pimentel, C. Chen, K.R. Anekalla, H. Abdala-Valencia, T.J. Yacoub, M. Antalek, M. Chi, S.F. Chiu, F. Gonzalez, P.J. Homan, S. Soberanes, A. Bharat, M.M. DeCamp, S.M. Bhorade, E.T. Bartom, R.I. Morimoto, W. Balch, J.I. Sznajder, N.S. Chandel, K.M. Ridge, N. Bagheri, L.A. Amaral, G. Budinger, H. Perlman, D. Winter, A.V. Misharin. Northwestern University and Scripps Research Institute. A5 656.5 Loss of Function Mutation in TIMP2 Gene Accelerates Tumorigenesis and Mortality in Murine Model of Lung Cancer Through EGFR Signaling. S. Kumar, S. Jensen, D. Peeney, A. Chowdhury, B. Wei, W.G. StetlerStevenson. NCI/NIH. A6 656.6 Whole Slide Quantitative Image Analysis Can Demonstrate Bleomycin Induced Dose-Dependent Increases in Fibrotic Areas Within Histologically Stained Rat Lung Tissue. A. Young, M. McElroy, S. Naylor, M. Anderson, A. Bigley, K. McGregor, L. Sherry. In Vivo Discovery, Charles River, United Kingdom, and OracleBio, United Kingdom. A7 656.7 The Role of Serine Protease in Diaphragm Development. Y. Hsu, S. Yang, C. Hung, C. Hung, H. Huang, I. Yu, S. Lin. Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taiwan, Liver Disease Prevention and Treatment Research Foundation, Taiwan, Graduate Institute of Medical Genomic and Proteomics, College of Medicine, National Taiwan University, Taiwan, Laboratory Animal Center, College of Medicine, National Taiwan University, Taiwan, Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taiwan, Center for Genomic Medicine and National Taiwan University, Taiwan.

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A8 656.8 Lysophosphatidic Acid Stimulation of Amphiregulin Shedding Enhanced Paracrine Role of BM CD11+ Cells. T. Liu, F. Gonzalez De Los Santos, Z. Wu, S.H. Phan. Univerisity of Michigan. A9 656.9 Sex Dependent Role of Activating Transcription Factor 3 (ATF3) Expression in Modulating the Asthmatic Phenotype in an Acute Mouse Model of Airway Neutrophilia. A. Spinelli, N. Fuentes Ortiz, M. Nicoleau, U. Sinha, C.R. Caruso, S. DiAngelo, Z. Chroneos, P. Silveyra. Penn State College of Medicine and MS Hershey Medical Center. A10 656.10 Effect of Seasonal Alterations of Air Quality Including Asian Sand Dust on Health-Related Quality of Life and Respiratory Symptoms in Korea. Y. Ishihara, M. Nakao, C. Kim, I. Hyun. Kurume University, Japan, Hallym University Dongtan Sacred Heart Hospital, Republic of Korea. A11 656.11 Resolution of Right Ventricular Fibrosis by a Cancer Chemotherapeutic Agent: A Novel Therapy to Treat Pulmonary Arterial Hypertension. V. Rybka, N.V. Shults, Y.F. Ibrahim, Y. Suzuki. Georgetown University and Minia University, Egypt. A12 656.12 Effect of Aliskiren, a Direct Renin Inhibitor, on Macrophage Accumulation in a Rat Model of Pulmonary Fibrosis Induced by Fat Embolism. A. Siddiqi, A. Syed, A. Yembur, D. Arif, R. Ponnapureddy, K. Tappeta, A. Fletcher, C. Patel, S. Hamidpour, A. Poisner, A. Molteni. University of Missouri-Kansas City Medical School, University of Kansas Medical Center. A13 656.13 Effect and Regulatory Mechanisms of LowDensity Lipoprotein on the Growth and Migration of A549 Human Lung Cancer Cells. S. Tsao. Taipei Medical University, Taiwan. A14 656.14 Heparanase Contributes to Idiopathic Pulmonary Fibrosis via Regulation of A20/TNFAIP Expression. Y. Yang, A. Lara, A. Rutebemberwa, E. Schmidt. University of Colorado Denver. A15 656.15 A Role of IL-21 in Pulmonary Fibroblast Activation. R. Sathiaseelan, C. Huang, L.K. Senavirathna, L. Liu. Oklahoma State University. A16 656.16 Effect of Losartan on 2 Types of Macrophages in a Chronic Rat Model of Fat Embolism. D. Arif, F. Khalafi, A. Siddiqi, S. Philips, A. Said, R. Ponnapureddy, K. Tappeta, A. Poisner, S. Hamidpour, A. Molteni. University of MissouriKansas City, University of Kansas Medical Center. A17 656.17 Capsaicin Synergizes with Camptothecin to Show Enhanced Apoptotic Activity in Small Cell Lung Cancer. J.R. Friedman, H.E. Perry, K.C. Brown, A.T. Akers, N.A. Nolan, W.D. Rollyson, Y.C. Chen, K.L. Denning, L.G. Brown, P. Dasgupta. Joan C. Edwards School of Medicine, Marshall University and Alderson Broaddus University. A18 656.18 The Assessment of Clinically Relevant Extracellular Matrix Markers in a Bleomycin-Induced Mouse Model of Lung Fibrosis. A. Young, P. Nath, D. Leeming, M. Karsdal, S. Brockbank, D. Rider, S. Cruwys. Discovery, Charles River, United Kingdom, Nordic Biosciences, Denmark and Grunenthal, Germany.

SUNDAY PATHOLOGY A19 656.19 Patient and Healthcare System Delay in Pulmonary Tuberculosis Patients, Tabriz, Iran 2012–2014. M.E. Kalan, H.Y. Sis, V. Kelkar, S.H. Harrison, J. Han. North Carolina Agricultral and Technical State University and Tuberculosis and Lung Disease Research Center, Iran. A20 656.20 Detection of Phenotypic Differences in Alveolar Macrophages Using Ionized Calcium-Binding Adapter Molecule 1 Marker. D.K. Meyerholz, C.M. Hogan, R.M. Glanz, J.A. Goeken, M.R. Leidinger, G.K. Ofori-Amanfo, L. McQuillen, K.M. Donovan, S.C. Harwani, H.A. Flaherty. University of Iowa Carver College of Medicine, University of Southern California and Iowa State University. A21 656.21 Influenza a Infection Decrease the Population of Tissue Resident Alveolar Macrophages. F. GonzalezGonzalez, A. McQuattie-Pimentel, S. Soberanes, M. Casalino-Matsuda, M. Chi, R. Piseaux, P. Sporn, S. Budinger. Northwestern University. A22 656.22 Developing an in Vivo Model of Reinke’s Edema. A. Durkes, P. Sivasankar. Purdue University.

657. IMMUNE RESPONSES IN PATHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Immunopathology Inflammation Presentation time: 11:45 am–1:45 pm A23 657.1 Activity Transcription Factor 3 Suppressed LPS-Induced Adipocyte Inflammation in Experimental Sepsis. Y. Wang, C. Cheng, P. Lai. National Chung Hsing University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Buddhist Tzu Chi General Hospital, Taiwan. A24 657.2 ATF3 Protects LPS-Induced Acute Pancreatic Inflammation via Modulating NFκB-Mediated iNOS Production in Mice. Y. Chen, Y. Tseng, C. Liu, H. Lin, C. Cheng, P. Lai. Tzu Chi University, Taiwan, Buddhist Tzu Chi General Hospital, Taiwan and Taipei Medical University, Taiwan. A25 657.3 Inflammasome Inhibition in Influenza A Virus Infected Juvenile Mice Leads to Improved Survival and Outcomes. N. Ravindran, C.M. Koch, K.M. Ridge, B.M. Coates. Northwestern University. A26 657.4 Pro-Inflammatory and Anti-Inflammatory Cytokine Expression in Tnf -/- and WT Mice with Chronic Colitis. T.M. Smith, A. Kozik, C.H. Nakatsu, Y.L. Jones-Hall. Purdue University. A27 657.5 The Role of Scleraxis in Intestinal Fibroblasts. C. Johnson, A. Nillas, T.A. Reaves. Medical University of SC. A28 657.6 Involvement of RAGE Signaling and Inflammatory Cytokine Elaboration Following in Vitro Exposure to Electronic Cigarette Liquid. K.M. Hirschi, J.B. Lewis, A.S. Ostergar, P.D. Hall, D.S. Broberg, J.A. Arroyo, P.R. Reynolds. Brigham Young University. A29 657.7 The Effect of Plumbagin on Proinflammatory Cytokines Expression in LPS-Activated BV-2 Microglia Cells. S.S. Messeha, N.O. Zarmouh, M.G. Kolta, K.F. Soliman. Florida A&M University.

A30 657.8 Comparative Analysis of Inflammatory Cytokines and Growth Factors in Young and Old Aged Normal Individuals. S. Rodrigues, A. Walborn, D. Hoppensteadt, J. Fareed, M. Rondina. Loyola University Chicago and University of Utah. A31 657.9 Tissue-Specific Expression Patterns of Tau and Ubiquitin Proteins Coordinated with Yersinia pestis Pathogenesis in a Non-Human Primate Model. C. Moyler, N. Chakraborty, A. Gautam, R. Hammamieh, M. Jett. The Geneva Foundation and U.S. Army Center for Environmental Health Research. A32 657.10 Identifying Key Domains in Endothelial IQGAP1 Critical for Leukocyte Transmigration. P. Dalal, D. Sullivan, W. Muller. Northwestern University. A33 657.11 Immunoproteomic Identification of Bovine Pericardial Heart Valve Antigens. K.Y. Gates, A. Dalgliesh, L. Griffiths. Mayo Clinic. A34 657.12 Sex, Age, and TNF Influence the Gut Microbiota in a Mouse Model of TNBS Colitis. A.J. Kozik. Purdue University. A35 657.13 Effect of Probiotic Pediococcus pentosaceus on Intestinal Permeability and Occludin Protein Distribution in a Murine Model of Colitis. L. Torres-Aguilar, L. RodriguezFragoso, F. Garcia-Vazquez, J. Reyes-Esparza. Universidad Autonoma del Estado de Morelos, Mexico and Instituto Nacional de Pediatria, Mexico. A36 657.14 Increased Urinary IL-6 and Mucosal COX-2 Expression in Patients with Idiopathic Detrusor Overactivity. H. Liu, H. Kuo. Tzu Chi Hospitial, Taiwan. A37 657.15 Inflammation Response of Phage-Based Films on Titanium Surface in Vitro. Y. Sun, B. Feng. Southwest Jiaotong University, People’s Republic of China. A38 657.16 PAD4 Deficiency Limits Kidney Dysregulation in a Murine Model of Shock/Sepsis. B. Biron Girard, Y. Chen, C. Chung, J.B. Reichner, A. Ayala. Brown University/Rhode Island Hospital and Rhode Island Hospital. A39 657.17 A Study Protocol for the Comparative Study of Biological and Metabolism Bio-Marker Between Healthy Population and Patients with Acne Vulgaris. K. Kim, I. Ha, E. Kim. College of Korean Medicine, Kyung Hee University, Republic of Korea, Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, Republic of Korea. A40 657.18 Gas6 Reduces Cellular Respiration and Increases Reactive Oxygen Species in Immortalized Human First Trimester Trophoblast Cells. C.A. Mejia, M.B. Appiah, J.B. Lewis, B.T. Bikman, J.M. Hansen, P.R. Reynolds, J.A. Arroyo. Brigham Young University. A41 657.19 Profiling of Inflammatory Biomarkers in Synovial Fluid from Patients Undergoing Primary Total Joint Arthroplasty. E. Finkler, C. Wanderling, C. Thorson, K. Galicia, S. Statz, J. Fareed, W. Hopkinson. Loyola University ChicagoSSOM. A42 657.20 Splenic Natural Killer Cell Phenotypes Are Heritable and Correlate with Lifespan. S.A. Bumgardner, Y. Zhou, Z. Jiang, E.J. Coe, R. Pazdro. University of Georgia. A43 657.21 Silica-Triggered Multi-Organ Autoimmune Gene Expression in Lupus-Prone Mice Is Ablated by Docosahexaenoic Acid Consumption. M.A. Bates, K.N. Gilley, D.N. Jackson-Humbles, J.R. Harkema, A. Holian, J.J. Pestka. Michigan State University and University of Montana. A44 469.1 A Novel Murine Model of Primary Sclerosing Cholangitis Associated Inflammatory Bowel Disease. K.D. Battista, C.T. Shearn, E.E. Alexeev, L.E. Glover, D.R. Petersen, S.P. Colgan, B.P. Fennimore. University of Colorado.

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658. PATHOBIOLOGY OF INFECTIOUS DISEASE Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Inflammation Immunopathology Presentation time: 11:45 am–1:45 pm A48 184.6 Production of TLRs Triggered Pro-Inflammatory Cytokines Through Calcium Dependent and Independent Pathways in HaCaT Cells. E. Kim, I. Ha, K. Kim. Kyunghee University Korean Medicine Hospital, Republic of Korea, College of Korean Medicine, Kyunghee University, Republic of Korea. A49 658.1 West-Nile Virus Replicon Particles Infect 293T Cells Expressing Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin Related. N. Leonard, N. Crowson, A. Madigan, M. Schmitz, E. Alcala, O. Martinez. Winona State University. A50 658.2 Addition of Retinoic Acid-Inducible Gene 1 to Enhance Ebola Virus-Like Particle Vaccine. E.O. Oredola, E. Pottebaum, M. Zell, O. Martinez. Winona State University. A51 658.3 Investigating the Potential Role of North American Animals as Hosts for Zika Virus. I. Ragan, E. Blizzard, R. Bowen. Kansas State University and Colorado State University. A52 658.4 Evaluation of Fluorescence Microsphere Immunoassay for Antibody Detection to Rift Valley Fever Nucleocapsid Protein and Glycoproteins. I. Ragan, B. Faburay, D.S. McVey, J.A. Richt, A.S. Davis, R.R. Rowland, W.C. Wilson. Kansas State University and USDA ARS. A53 658.5 Reverse Transcriptase Real Time PCR Detection of Rift Valley Fever Virus RNA in Formalin-Fixed, Paraffin-Embedded Tissues. D. Upreti, W.C. Wilson, J.A. Richt, A.S. Davis, J.D. Trujillo. Kansas State University, USDA and ARS. A54 658.6 Co-Infection with Giardia duodenalis Protects the Host Against Enteropathogenic Escherichia coli via NLRP3 Inflammasome-Dependent Anti-Microbial Peptide Production. A. Manko, J. Motta, J. Cotton, A. Oyeyemi, B. Vallance, P. Beck, J. Wallace, A. Buret. University of Calgary, Canada and University of British Columbia, Canada. A55 658.7 Effects of Acute Sepsis on Renal Structure and Sympathetic Innervation in Mice. T. Alkhateeb, T.R. Ozment, G.A. Youngberg, M.E. Howell, C.A. Stuart, J.B. Price, T.C. Jones, D.L. Williams, T.E. Blair, D.B. Hoover. East Tennessee State University. A56 658.8 Gelsolin, but Not Mucin, Inhibits P. aeruginosa Swimming Motility in Vitro. A.B. Husak, S.A. Busch, J. Robarge, J.L. Bankers-Fulbright. Augsburg College.

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A57 658.9 Method Development for the Micromolar Analysis of Pyocyanin (PYO) in Blood and Urine via Mass Spectrometry (MS). T.P. Mawhinney, D.L. Chance, J.K. Waters, V.V. Mossine. University of Missouri. A58 658.10 RGDSK Peptide Functionalized Helical Rosette Nanotubes (RGDSK-HRNs) Block Integrin αvβ3 and inhibit E. coli Adherence to Intestinal Porcine Epithelial 1 Cell Line (IPEC1) in Vitro. N. Le, C. Quach, G. Aulakh, V. Gerdts, H. Fenniri, B. Singh. Western College of Veterinary Medicine, University of Saskatchewan, Canada, Vaccine and Infectious Disease Organization—International Vaccine Centre (VIDO—InterVac), Canada, Northeastern University, Faculty of Veterinary Medicine and University of Calgary, Canada. A59 658.11 Development of an in Vitro Bladder Epithelial Cell Culture System. S. Kim. Washington University in St Louis. A60 658.12 Model Systems to Study the Pathogenesis of Zika Virus-Mediated Eye Disease. L.E. Martinez, D. Contreras, M.K. Jones, V. Gangalapudi, J. Tang, S. Wang, V. Arumugaswami. Cedars-Sinai Medical Center. A61 658.13 Transcriptomic and Proteomic Analysis to Delineate the Mechanism of Antibiofilm Activity of 3-Furancarboxaldehyde on Group A Streptococcus. S. Karutha Pandian, G. Ashwinkumar Subramenium. Alagappa University, India. A62 658.14 Inhibition of Biofilm and Virulence of Candida albicans by a Marine Bacterial Isolate from Palk Bay. G. Ashwinkumar Subramenium, T.K. Swetha, S. Karutha Pandian. Alagappa University, India.

659. NEUROPATHOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Neuropathology Presentation time: 11:45 am–1:45 pm A63 659.1 Floating Microelectrode Arrays Chronically Implanted Into the Feline Peripheral Nerve Elicit a Characteristic Tissue Response. C.L. Kolarcik, K. Puglisi, A. Lesniak, A.J. Demetris, L.E. Fisher, R.A. Gaunt. University of Pittsburgh. A64 659.2 Cyclin A2 Loss Impairs Hippocampal Development. M. Goksel, P. Gygli, J. Chang, B. Goksel, H.N. Gokozan, R. Nelson, C. Czeisler, J.J. Otero. The Ohio State University. A65 659.3 Visualization of Neuronal Connectivity in NPARM PHOX2b Mutants with a Modified PACT Protocol. S.R. Fair. The Ohio State University. A66 659.4 1,2,3,4,6 Penta-O-Galloyl-β-D-Glucose Attenuates LPS/IFNγ-Induced MCP-5 and Pro-MMP-9 Cytokines Release in BV-2 Microglia Cells by Inhibiting NFκB and MAPK signaling Proteins. P.F. Mendonca, E.F. Taka, D.F. Bauer, K.F. Soliman. Florida A&M University.

SUNDAY PATHOLOGY A67 659.5 Naturally, Occurring Neurotrophic Factor from Mu Bie Zi (Momordica cochinchinensis) Seeds. E.A. Mazzio, B. Georges, K.F. Soliman. Florida A&M University. A68 659.6 Alzheimer’s Disease: Prevention, Symptoms and Treatment. L. DiCarlo, G.P. Einstein, O.L. Tulp. USAT Montserrat, Montserrat. A69 659.7 Ablation of Mitochondria Fusion Protein Mfn2 Causes an Oxidative Stress Response and Eventual Neuronal Death in the Hippocampus and Cortex. S. Jiang, X. Wang, P. Nandy, C. Wang, S. Torres, S.L. Siedlak, X. Zhu. Case Western Reserve University. A70 659.8 Caffeine May Affect Apoptosis and Autophagy Activity to Promote Dopaminergic Cells Survival Under the Rotenone Induced Parkinson Disease Model. C. Luo,Y. Huang, B. Huang, T. Lu, Y. Fu. Department of Biomedical Science and Environmental Biology, Kaohsiung Medial University, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Taiwan, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Department of Biomedical Science and Environmental Biology, Center for Infectious Disease and Cancer Research and Kaohsiung Medical University, Taiwan. A71 659.9 Investigating the Underlying Mechanisms of Chemosensory Dysfunctions in Alzheimer’s Disease Using Caenorhabditis elegans with Mutations in Presenilin 1. M. Parvand, T. Bozorgmehr, C. Rankin. University of British Columbia, Canada. A72 659.10 Aberrant Histone Turnover in Alzheimer’s Disease. J.A. Dowell, M.A. Gitcho, J.M. Denu. Wisconsin Institutes for Discovery, Delaware State University and University of Wisconsin. A73 659.11 The Effect of Cardiolipin on Microglial Activation and Microglia-Mediated Neuronal Death. C. Pointer, A. Klegeris. University of British Columbia Okanagan, Canada. A74 659.12 High Fat Diet Increases Cognitive Decline and Neuroinflammation in a Model of Orexin Loss. C.M. Duffy, J.P. Nixon, T.A. Butterick. Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota’s Discovery, Research, and Innovation Economy, Brain Conditions and Minnesota Obesity Center. A75 659.13 Innate Immunity and Alzheimer’s Disease. A. Affaneh, M. Lahey, Z. Langston, E. Cudaback. DePaul University. A76 659.14 APOE Genotype-Dependent Differential Influences on MS. M. Lahey, Z. Langston, A. Affaneh, E. Cudaback. DePaul University.

A77 659.15 APOE Genotype Influences Glial Activity in MS. Z. Langston, M. Lahey, A. Affaneh, E. Cudaback. DePaul University. A78 659.16 Better Targeting, Better Efficiency of AdenoAssociated Virus Gene Transfer in the Central Nervous System for Expression of Retromer Proteins. D.D. Porter, K.L. Jackson, R.D. Dayton, R.L. Klein. King University, LSU Health Shreveport and LSU Health Science—Shreveport. A79 659.17 Surface Area May Be a More Useful Risk Factor for Cerebral Aneurysm Rupture Than Maximum Diameter. S. Fukuda, Y. Shimogona. Kyoto Medical Center, Japan and Tohoku University, Japan. A80 659.18 Inhibition of Stroke-Induced Injury by Phlebotomy. Y. Tsai, H. Liou, S. Tang, H. Liou, J. Jeng, W. Fu. Institute of Pharmacology, College of Medicine, National Taiwan University, Taiwan, Department of Neurology and National Taiwan University Hospital, Taiwan. A81 659.19 Pathological Role of Two Chemokines RANTES and MIF in Ischemic Stroke. Y. Liu, S. Tang, Liou, H. Tu, K. Kang, H. Liou, J. Jeng, W. Fu. National Taiwan University, Taiwan and National Taiwan University Hospital, Taiwan. A82 659.20 Modeling the Ischemic Neurovascular Unit in a Dish Using Patient-Specific Induced Pluripotent Stem Cells. S. Page. TTUHSC. A83 659.21 Animating External Magnetic Guidance of Intrathecally Delivered Gold-Coated Nanoparticles to Treat Intramedullary Spinal Tumors. A. Orland, K. Brennan, L. Lebowicz, C. Wellman, A. Mehta. University of Illinois at Chicago. A84 659.22 Evaluation of Immunohistochemical Markers for Application in a Novel Neurofibromatosis-1 Porcine Model. D.K. Meyerholz, G.K. Ofori-Amanfo, M.R. Leidinger, D. Quelle, B. Darbro, K. Panzer, J.C. Sieren, R. Khanna, C. Rogers, K. White, J. Weimer. University of Iowa Carver College of Medicine, University of Iowa, University of Arizona, Exemplar Genetics, Sanford Research and University of South Dakota. A85 659.23 Regulator of G-Protein Signaling 6 (RGS6) Expression in Human Substantia Nigra Pars Compacta (SNc) and Loss in Parkinson’s Disease (PD). Z. Luo, K.E. Ahlers, J. Yang, B. Chakravarti, H.E. Stevens, N.S. Narayanan, R.A. Fisher. The University of Iowa.

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Pharmacology 660. PHARMACOLOGY EDUCATION I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Pharmacology Education Presentation time: 12:30 pm–2:30 pm D1 660.1 A Team-Based Assignment to Integrate Basic Science and Pharmacotherapeutic Principles for Anticancer Agents. P. Jungsuwadee, P. Sakharkar, S. Kurup. School of Pharmacy, Fairleigh Dickinson University, and College of Pharmacy, Roosevelt University. D2 660.2 Promoting the Active Learning of Pharmacology and Clinical Therapeutics Utilizing Team-Based Learning (TBL) Methods in Second Year Systems Modules. L. Gorman. UCF College of Medicine. D3 660.3 The Use of Patient-Oriented-Problem-Solving (POPS) in Pharmacology Exercises to Develop Simulated Scenes for Application During TBL. M.J. Hernandez, S.J. Foldy, F.J. Abene, T.J. Lindsey, J. Giannini. Alabama College of Ostepathic Medicine. D4 660.4 Tools Enhance Learning of Medical Pharmacology. Q. Zhong. St Matthews University School of Medicine, Cayman Islands. D5 660.5 Hands-on Modeling/Simulation Using MATLAB and SimBiology Improves Student Learning in Graduate Pharmacology and Pharmaceutical Sciences Education. J. Chang, H.H. Alsulimani, M. Han, Q. Ye, F. Buyukozturk, J. Kim. Northeastern University, The MathWorks and Inc. D6 660.6 A Process-Oriented Guided Inquiry Approach to Teaching Pharmacology. B.B. Pond. East Tennessee State University Gatton College of Pharmacy.

661. ALCOHOL Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D7 661.1 Divergent Influence of Binge Drinking and Subsequent Intermittent Stress on Drinking Behaviors and Select Brain Protein Levels in Male and Female Mice. L.L. Devaud, A. Garcia, M. Perius, D.A. Finn. Pacific University Oregon and Oregon Health & Sciences University. D8 661.2 Effects of Sequential Exposure to Ethanol and Methamphetamine on Tissue Contents of Dopamine, Serotonin and Glutamate in Wistar Rats. A.H. Almalki, S.C. Das, F.S. Alshehri, Y.S. Althobaiti, Y. Sari. University of Toledo.

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D9 661.3 Effects of Clavulanic Acid on Ethanol Intake and Glial Glutamate Transporters Expression in Alcohol Preferring Rats. A.Y. Hakami, Y. Sari. University of Toledo. D10 661.4 Organic Cation Transporter 3 Upregulation in Serotonin Transporter Deficient Mice Potentiates EthanolInduced Serotonin Clearance Impairments. T.L. Gilman, R.E. Horton, N.L. Baganz, S.R. Alvarado, L.C. Daws. University of Texas Health Science Center at San Antonio. D11 661.5 Are Exon 11-Associated Variants of the OPRM Gene Involved in Alcohol Reward? T. Brown, S. Martinez, J. Xu, Y. Pan, G. Rossi. Villanova University, Long Island University and Memorial Sloan Kettering Cancer Center. D12 661.6 Cortical Circuit Dynamics During PunishmentResistant Alcohol Drinking. C.A. Siciliano, Y. Leow, C. Vander Weele, E. Kimchi, D. Xu, X. Chen, K.M. Tye. Massachusetts Institute of Technology. D13 661.7 PARP Mediates Binge Alcohol-Induced Neurodegeneration in Adult Rats. D.E. Kouzoukas, J.A. Schreiber, N.F. Tajuddin, S. Kaja, H. Kim, E.J. Neafsey, M.A. Collins. Loyola University Medical Center, Edward Hines Jr. VA Hospital and NIAAA.

662. DRUG EFFECTS ON LEARNING AND COGNITION Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Behavioral Pharmacology Neuropharmacology Presentation time: 12:30 pm–2:30 pm D14 662.1 Novel Lipophilic Carbonic Anhydrase Activators Protect Mice from Recognition Memory Deficits Produced by Scopolamine. R.K. Sanku, B. Draghici, Y. Pan, M. Ilies, E. Walker. Temple University. D15 662.2 Anti-Muscarinic Drug Effects on Murine Cognition: A Pilot Study. R. Theobald, A. Blanchard, C.J. Morgan. A.T. Still University of Hlth Sci and Truman State University. D16 662.3 Effects of Self-Administered Oxycodone on Learning and Cognitive Flexibility in Nonhuman Primates. B.D. Kangas, E.N. Porter, J. Bergman. Harvard Medical School and McLean Hospital. D17 662.4 Role of Phosphodiesterase 4D in Memory and Cognition. C. Zhang, Y. Xu, M. Gurney, J. O’Donnell. SUNYBuffalo and Tetra Discovery Partners LLC. D18 662.5 Combined Norepinephrine and Dopamine Reuptake Inhibition for Long-Term Memory Enhancement. M.M. Pantoni, S.G. Anagnostaras. UC San Diego. D19 662.6 Effects of Juvenile Methylphenidate on LongTerm Retention in Adulthood. M. McWaters, E. Anderson, L. Matuszewich. Northern Illinois University.

SUNDAY PHARMACOLOGY D20 662.7 A New Testing Paradigm for Evaluating the Motor and Non-Motor Symptoms of 6-Hydroxydopamine Lesions in Rats. R. Spry, M. Hibicke, D. Rogers, K. Rambacher, R. Hayslett, N. Moniri, K. Murnane. Mercer University. D21 662.8 Discriminative Stimulus Effects of Novel Carbonic Anhydrase Activator B. D117. T.A. Spoon, R.K. Sanku, B. Draghici, M.A. Ilies, E. Walker. Temple University School of Pharmacy. D22 662.9 Methamphetamine Augments HIV-1 Tat Mediated Memory Deficits by Altering the Expression of Synaptic Proteins and Neutrophic Factors. A. Nookala, A. Kumar. University of Missouri Kansas City. D23 662.10 The Dual Effect of HIV-1 Tat and Methamphetamine on Dopamine Transporter Function. C.N. Appadoo, D. Sambo, T. Alonge, B. Harvey, H. Khoshbouei. University of Florida. D24 662.11 Endogenous Melatonin Decreases Place Preference for Methamphetamine Through a Learning and Memory Independent Mechanism in C57BL/6 Mice. S.J. Clough, T. Kasahara, K.M. Veros, R.L. Hudson, M.L. Dubocovich. Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY and RIKEN Brain Science Institute, Japan. D25 662.12 Interactive Effects of Hormone Status and ?9-THC Administration on Memory in Female Rats. A.C. Fournett, P. Winsauer. Louisiana State University Health Sciences Center. D26 662.13 Learning and Memory Deficits in a Novel Mouse Model of Alzheimer’s Disease. K. Murnane, C. Daphney. Mercer University.

663. CENTRAL NERVOUS SYSTEM DRUG DEVELOPMENT Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Neuropharmacology Presentation time: 12:30 pm–2:30 pm D27 663.1 Comparative Studies of AMPA Receptor Positive Allosteric Modulators PF-04958242 and PF-04531686. J.R. Stolz, T. Ishii, G. Swanson. Northwestern University and Nippon Medical School, Japan. D28 663.2 Elucidating Functional Selectivity at the 5-HT2A Receptor. G. Billac, C. Nichols. LSU Health Sciences Center. D29 663.3 Structure-Guided Design for Agonist Selectivity with α7-NAChRs. G.A. Camacho-Hernandez, K. Kaczanowska, M. Harel, C. Beck, L. Doan, H. Binding, P. Taylor. University of California San Diego and Universidad Autonoma de Baja California, Mexico. D30 663.4 Novel Adenine-Based Inhibitors Define a Pharmacophore with Selectivity for the cAMP Sensor NCS-Rapgef2 Versus PKA, Epac and Adenylate Cyclase in Neuroendocrine Cell Lines. L.E. Eiden, R. Alvarez, M.V. Eiden, W. Xu, A.C. Emery. NIMH-IRP.

D31 663.5 Discovery and Optimization of ML417: A Potent and Highly Selective D3 Dopamine Receptor Agonist. A.E. Moritz, R. Free, W. Weiner, E. Akano, M. Bachani, T. Doyle, N. Southall, M. Ferrer, J.A. Javitch, J. Steiner, J. Aubé, K. Frankowski, D.R. Sibley. NIH, University of North Carolina and Columbia University. D32 663.6 The in Vivo Pharmacodynamic and Biopharmaceutical Characterization of a Novel Dual Mechanism, Rapid-Acting Antidepressant. J.N. Talbot, D.B. Rawlins, F. Movahedi, M.Y. Zhudeva, A. Vo, J. Phan, J. Dorigatti, G. Velazquez, R.D. Kirsh, V.K. Yellepeddi. Roseman University of Health Sciences. D33 663.7 The Rho-Kinase Inhibitor, Fasudil, Has Antidepressant-Like Efficacy in Adolescent Mice. L. Shapiro, S. Gourley. Emory University.

664. GPCRS I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D34 664.1 β2-Adrenergic Receptor Control of Endosomal PTH Receptor Signaling via Gβγ. F. Jean-Alphonse, V. Wehbi, J. Chen, J. Taboas, K. Xiao, J. Vilardaga. University of Pittsburgh. D35 664.2 Functional Selectivity of GPCR-Directed Drug Action Through Location Bias. R. Irannejad. UCSF. D36 664.3 PAR1 and P38 MAPK Regulation of Endothelial Pro-Inflammatory Responses. C. Rada, N. Grimsey, I. Canto, J. Trejo. UCSD. D37 664.4 Optimization of a Novel D2 Dopamine Receptor Antagonist Scaffold Reveals Exceptionally Selective and Potent Lead Molecules. M.M. Day, A.E. Dulcey, D. Bayron, C.R. Stang, A.E. Moritz, T. Doyle, J.A. Javitch, N.T. Southall, M. Ferrer, J.J. Marugan, D.R. Sibley, R. Free. NIH/NINDS, NIH/NCATS and Columbia University. D38 664.5 A Critical Role for Transmembrane Five in Regulating Biased Signaling of the D2 Dopamine Receptor. E.C. Gonye, A.M. Moore, L.S. Chun, A.E. Moritz, L. Shi, D.R. Sibley, R. Free. NINDS/NIH and NIDA/NIH. D39 664.6 Structural Basis for Regulation of GPR56 by Its Alternatively Spliced Extracellular Domains. D. Arac. University of Chicago. D40 664.7 Structural and Functional Studies of LatrophilinFamily Adhesion G-Protein Coupled Receptors. K. Leon, Y.C. Lu, O. Nazarko, R. Sando, G. Salzman, T. Südhof, D. Araç University of Chicago and Stanford University. D41 664.8 Adhesion G Protein-Coupled Receptor Activation by Novel Small Molecule Modulators. H.M. Stoveken, A.V. Smrcka, G.G. Tall. University of Michigan and University of Rochester. D42 664.9 Delta Opioid Receptor Antagonism/Inverse Agonism and Its Effect on Mu Opioid Receptor Signaling in SH-SY5Y Cells. N. Griggs, H. Mosberg, J. Traynor. University of Michigan.

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PHARMACOLOGY SUNDAY D43 664.10 Role of GPCRs and Gαs in the Antidepressant Action of Ketamine. N. Wray, J. Schappi, M.M. Rasenick. University of Illinois at Chicago, University of Illinois College of Medicine and Jesse Brown VAMC. D44 664.11 GPCRs in Pulmonary Arterial Smooth Muscle Cells as Novel Targets in Pulmonary Arterial Hypertension. M.W. Gorr, K. Sriram, P.A. Insel. University of California San Diego. D45 664.12 Identifying Receptor-Ligand Interactions That Drive Gβγ-Dependent Signaling. R.B. Cameron, C.B. Beeson, R. Schnellmann. Medical University of South Carolina and University of Arizona. D46 664.13 Leveraging a Novel ITIM Motif in GPCRs for Targeted Antibody Design. L.T. Belcastro, A. Jancina, C. Adams, R.D. Paulukinas, C.C. Moore. Cancer Biology Program, The Wistar Institute and University of the Sciences, Philadelphia College of Pharmacy and USciences.

665. HETEROTRIMERIC G PROTEINS AND G PROTEIN MODULATORS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Molecular Pharmacology Presentation time: 12:30 pm–2:30 pm D47 665.1 Identification of Binding Sites for Small Molecule Modulators of Gβγ Signaling. I.J. Fisher, S. Connelly, M. Dumont, A. Smrcka. University of Rochester and University of Michigan. D48 665.2 Critical Role of R7 Binding Protein in the Sensation of Acute and Pathologic Itch. M. Pandey, J. Zhang, P. Adikaram, S.K. Mishra, B. Harris, J.F. Kahler, A. Loshakov, R. Sholevar, A. Genis, M. Hoon, R. Neubig, W.F. Simonds. NIDDK, NSCU, NIDCR and Michigan State University. D49 665.3 Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis. Y. Xie, H. Jiang, Q. Zhang, S. Mehrotra, P.W. Abel, M.L. Toews, D.W. Wolff, S. Rennard, R.A. Panettieri Jr., T.B. Casale, Y. Tu. Creighton University School of Medicine, University of Nebraska Medical Center, University of South Carolina School of Medicine Greenville, AstraZeneca, United Kingdom, University of Pennsylvania and University of South Florida School of Medicine. D50 665.4 Functional Mechanisms of Novel G Protein Inhibitor Ligands as Vasodilators. M.M. Meleka, M. Medcalf, K.D. Moeller, P. Osei-Owusu. Drexel University and Washington University. D51 665.5 Identification of Novel Small Molecule Stabilizers of RGS4 Protein Levels. B. Karaj, B. Sjogren, R.R. Neubig. Michigan State University. D52 665.6 Molecular Characteristics of FBXO44Mediated RGS2 Protein Degradation. B. Sjogren. Michigan State University. D53 665.7 RGS2 Modulates the Selection of Gαi/o Subtype Involved in Dopamine D2 Receptor Signaling. D.J. Luessen, T.P. Hinshaw, H. Sun, R. Chen. Wake Forest School of Medicine.

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D54 665.8 Investigating Regulator of G-Protein Signaling (RGS) Protein Dynamics by Hydrogen/Deuterium Exchange. V.S. Shaw, A.L. Schilmiller, H. Vashisth, R.R. Neubig. Michigan State University and University of New Hampshire. D55 665.9 Distribution of Activator of G-Protein Signaling 3 Within the Aggresomal Pathway: Role of Serine/Threonine Residues in the G- Protein Regulatory Domain and Lysosomal Processing. A. Vural, S. Oner, D. Ma, S.M. Lanier. Department of Pharmacology, Wayne State University School of Medicine, Istanbul Medeniyet University, Goztepe Research and Training Hospital, Turkey, Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara. D56 665.10 Cutting the Brakes to Prevent Type 2 Diabetes Onset: Augmenting Insulin Secretion and Conserving Pancreatic Beta-Cell Mass by Deleting Gαz. J. Wisinski, A. Reuter, M. Kimple. University of Wisconsin-Madison. D57 665.11 Structural Basis for Activation of Gαi by NonReceptor Guanine Nucleotide Exchange Modulators (GEMs). N.A. Kalogriopoulos, S. Rees, N. Aznar, N. Sun, G. Chang, P. Ghosh, I. Kufareva. University of California-San Diego. D58 665.12 Priming GPCR Signaling Through the Synergistic Effect of Two G Proteins. T.M. Gupte, R.U. Malik, R.F. Sommese, M. Ritt, S. Sivaramakrishnan. University of Minnesota and Twin Cities. D59 665.13 The MAPK Pathway Bisects Heterotrimeric G Protein Signaling Through Control of G Protein Subunit Biosynthetic Protein Folding. M.M. Papasergi-Scott, B.R. Patel, M. Gabbay, G. Tall. University of Rochester and University of Michigan. D60 665.14 Effects of Osteoblast-Specific Gαs OverExpression on Skeletal Development Using a Transgenic Mouse Model. L. Zhang, K. Sugamori, C. Claridge, A. Dela Cruz, J. Mitchell, M. Grynpas. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Canada and University of Toronto, Canada. D61 665.15 Targeting and Delivery of Heterotrimeric G-Proteins to Primary Cilia. C. Edwards, N. Lambert. Medical College of Georgia.

666. DRUG DISCOVERY AND DEVELOPMENT: GENERAL Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Discovery and Development Presentation time: 12:30 pm–2:30 pm D62 666.1 Computational Prediction of Off-Target Pharmacology for Discontinued Drugs. M. Rao, M. Liguori, S. Mantena, S. Mittelstadt, E. Blomme, T. Van Vleet. AbbVie. D63 666.2 The Effect of Pentadecapeptide BPC 157 on Episcleral Vein Cauterization Model in Rats. T. Kralj, A. Kokot, K. Kasnik, D. Drmic, M. Zlatar, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia, Faculty of Medicine and J.J. Strossmayer University of Osijek, Croatia.

SUNDAY PHARMACOLOGY D64 666.3 Optimal Strategies for Convection Enhanced Delivery (CED) of DNA Brain-Penetrating Nanoparticle (DNABPN) for Glioblastoma (GBM) Treatment. K. Negron, A. Ali, B. Lu, C. Zhang, J. Hanes, J. Suk. Johns Hopkins School of Medicine. D65 666.4 Damaging Effect of Retrobulbar L-NAME Application in Rats Counteracted by Stable Gastric Pentadecapeptid BPC 157. M. Zlatar, A. Kokot, L. Batelja Vuletic, T. Kralj, D. Drmic, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia, Faculty of Medicine and J.J. Strossmayer University of Osijek, Croatia. D66 666.5 Esophageal Cytoprotection in Rats. Stable Gastric Pentadecapeptide BPC 157 and Omeprazole. M. Peklic, A. Boban Blagaic, T. Becejac, J. Suran, D. Drmic, S. Seiwerth, P. Sikiric. School of Medicine, University of Zagreb, Croatia and University of Zagreb Faculty of Veterinary Medicine, Croatia. D67 666.6 Chlorpromazine Hydrochloride Suppresses Visceral Hypersensitivity to Colorectal Distension in a Rat Model of Irritable Bowel Syndrome. T. Asano, M. Takenaga. St. Marianna University, Japan. D68 666.7 Quantitative Tissue Distribution and Pharmacokinetics of IW-1973, a Novel Clinical-Stage sGC Stimulator, After Oral Administration in Rats. A. Banijamali, J. Wakefield, T. Barden, A. Carvalho, D.R. Zimmer, M. Currie, K. Hall, E. Solon, J. Masferrer, M. Ribadeneira. Ironwood Pharmaceuticals and QPS. D69 666.8 Biological Activity of ResveratrolHydroxycinnamic Acid Ester Conjugates. A.J. Urbaniak, K. Kacprzak, F.S. Senol, I. Erdogan Orhan, A. RadominskaPandya. University of Arkansas for Medical Science, Adam Mickiewicz University, Poland and Gazi University, Turkey. D70 666.9 Structure Activity Relationship Studies for Inhibitors of Type 1 and Type 8 Adenylyl Cyclase Isoforms. M. Soto Velasquez, N. Rana, D. Alongkronrusmee, K.F. Ejendal, K. Kyei-Baffour, R.M. Van Rijn, M. Dai, M.A. Lill, V.J. Watts. Purdue University.

667. GENERAL TOXICOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Toxicology Presentation time: 12:30 pm–2:30 pm D71 667.1 Sub Acute Effect of Pirimiphos Methyl (Actellic 2% Dust) on Oxidative Stress in Albino Rats. C.I. Nosiri, C. Anyanwu, A.O. Ibeh. Abia State University, Nigeria, Bizmart Pharmaceuticals. D72 667.2 Aryl Hydrocarbon Receptor Activation Differentially Alters Cholera Toxin-Specific IgA Levels in Feces and Serum. A. King, E. Gawronska, M. Metten, G. DeKrey. University of Northern Colorado and Colorado State University. D73 667.3 Modulation of the Aryl Hydrocarbon Receptor Protein Levels by p23 Is Hsp90-Independent. B. Pappas, M. Cheung, K. Ngo, T. Chang, C. Ng, W.K. Chan. University of the Pacific.

D74 667.4 Evaluation of the Glycan Receptor Ligand Mannan as a Potential Mitigation Strategy for Non-TargetRelated Toxicities of Antibody-Drug Conjugates. R. Ciurlionis, S.R. Mantena, C.J. Dunn, M. Klapczynski, W.R. Buck, T.R. van Vleet. Abbvie and Inc. D75 667.5 Cytotoxicity of Ethanol Extracts from Glanded and Glandless Cottonseed in Cultured Mouse RAW Macrophages. H. Cao, K. Sethumadhavan. USDA-ARS. D76 667.6 Calabash Clay (Nzu) Affects Pregnancy in Whistar Albino Rats. J.S. Aprioku, E.M. Ogwo-ude. University of Port Harcourt, Nigeria. D77 667.7 Evaluation of Embryotoxicity and Teratogenicity of Maltodextrin-Coated Cadmium Sulfide Quantum Dots. J. Sánchez, J. Reyes-Esparza, L. Rodriguez-Fragoso. Universidad Autónoma del Estado de Morelos, Mexico and Universidad Autonoma del Estado de Morelos, Mexico. D78 667.8 In Vivo and in Vitro Effects of Work Site Fracking Sand Dust (FSD) Inhalation on Rat Lung: Dose- and Time-Response Evaluation. J.S. Fedan, J.A. Thompson, K.A. Russ, D. Newcomer, W. McKinney, A.M. Cumpston, M.C. Jackson, J.S. Reynolds. National Institute for Occupational Safety and Health. D79 667.9 Investigation of Pyrrolizidine Alkaloid-Induced Pulmonary Toxicity. W. Lian, J. Ma, C. Wong, L. Zhu, G. Lin. The Chinese University of Hong Kong, People’s Republic of China, Joint Research Laboratory of Promoting Globalization of Traditional Chinese Medicines between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China. D80 667.10 The ProS Peptide of Porcine Cathelicidins Is an Active Component of Swine Concentrated Animal Feeding Operations (CAFOs) Dust That Mobilizes Calcium and Stimulates Proliferation in Human Airway Smooth Muscle Cells. M.L. Toews, N.A. Schulte, Y. Tu, R.A. Panettieri; Jr, D.J. Romberger, G. Tian. University of Nebraska Medical Center, Creighton University School of Medicine, University of Pennsylvania and VA Nebraska-Western Iowa Healthcare System. D81 667.11 Indoxyl Sulfate Involves Abnormality of Iron Metabolism Through Hepcidin Regulation. H. Hamano,Y. Ikeda, H. Watanabe, Y. Horinouchi, Y. Izawa-Ishizawa, K. Ishizawa, K. Tsuchiya, T. Tamaki. Tokushima University Graduate School, Japan and Tokushima University Hospital, Japan. D82 667.12 Differential Cardiovascular Physiology and Pathology in Selected Lineages of Miniature Swine and Comparison to Human. A.M. Stricker-Krongrad, D. Brocksmith, G.M. Bouchard. Sinclair Research Center LLC and Sinclair Bio Resources. D83 667.13 The Anti-Apoptotic Effect of Methanol Leaf Extract of Azadirachta indica on Lead Acetate-Induced Apoptosis in Cardiac and Renal Tissues of Male Wistar Rats. T.E. Adeyeoluwa, A.A. Oyagbemi, A.A. Adedapo, T.O. Omobowale. University of Ibadan, Nigeria. D84 667.14 Stable Gastric Pentadecapeptide BPC 157 Antagonizes Hydrogen Peroxide Induced Oxidative Stress in Drosophila melanogaster. A. Filosevic, R. Andretic Waldowski, T. Vidovic, P. Sikiric, D. Drmic. Department of Biotechnology, University of Rijeka, Croatia, School of Medicine and University of Zagreb, Croatia.

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668. EXPRESSION AND REGULATION OF DRUG METABOLISM ENZYMES Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D85 668.1 Efavirenz Treatment Activates XBP1 Splicing in Primary Hepatocytes: A Comparison Across Species and an Investigation Into the Role of PXR. C.J. Heck, N.N. Bumpus. Johns Hopkins University School of Medicine. D86 668.2 Transcriptional Regulation of Disease-Drug Interactions. W. Xie. University of Pittsburgh. D87 668.3 Structural Differences in Gut Microbiota Lead to Altered Hepatic Expression of Drug Disposition Genes (DDG) in Mice. Y. Guo, S.-J. Cho, E. Chung, J.-S. Park, H. Jeong. University of Illinois at Chicago. D88 668.4 atRA Upregulates SHP Expression Through RXR Activation. K. Won, H. Jeong. University of Illinois at Chicago. D89 668.5 RNA Sequencing Analysis of Commensal Microbial Regulation of Host Intestinal Transcriptome. Z.D. Fu, F.P. Selwyn, J.Y. Cui. University of Washington. D90 668.6 Effect of Novel Interactions Between Gut Microbiome and PBDEs on the Regulation of Intestinal Drug-Processing Genes Expression. S. Lee, C. Li, J.Y. Cui. University of Washington. D91 668.7 Crypt Organoids Culture as an in Vitro Model in Studying Regulation of Xenobiotic Metabolism and DrugInduced Cytotoxicity. S. Chen, W. Lu, E. Rettenmier, M. Yueh. University of California at San Diego. D92 668.8 Elucidating the Effect of DNA Methylation on the Regulation of Human Neonatal Fc Receptor (FcRn). D.C. Ferguson, J.G. Blanco. University at Buffalo. D93 668.9 Comparison of Expression Profiles of DrugMetabolizing Enzymes Between Human Liver and the Hepatic Cell Lines Hepg2, Hep3b, and Huh7: A Parallel Reaction Monitoring (PRM)-Based Targeted Proteomics Study. J. Shi, X. Wang, H. Zhu. University of Michigan. D94 668.10 Novel Interactions Between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals PBDEs. C. Li, S. Cade, I. Schultz, L. Kuo, T.K. Bammler, J. Cui. University of Washington and Pacific Northwest National Laboratory. D95 668.11 Differential Gut Microbiota Modulates the Susceptibility to Acetaminophen-Induced Hepatotoxicity. S. Cho, G. Chlipala, S. Green, H. Lee, H. Jeong. University of Illinois at Chicago. D96 668.12 Global Gene Expression Changes Between Human Prenatal and Pediatric Liver. C.A. Vyhlidal, M. Xiong, D.P. Heruth, S.Q. Ye. Children’s Mercy Kansas City and University of Missouri-Kansas City. D97 668.13 L-Tryptophan and Bacterial Modulation of Intestinal and Hepatic Gene Expression. J.L. Dempsey, C.Y. Li, J.Y. Cui. University of Washington.

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D98 668.14 Downregulation of Intestinal P450 Enzymes in a Mouse Model of Ulcerative Colitis and the Impact on P450Mediated Drug Metabolism. X. Fan, X. Ding, Q. Zhang. New York State Department of Health, State University of New York at Albany and SUNY Polytechnic Institute. D99 668.15 Genomic and Proteomic Approaches to Identify Mechanism of Regulation of Cytochrome P450 3A Enzymes. G. Taneja, W. Jiang, S. Maity, C. Coarfa, B. Moorthy, R. Ghose. University of Houston and Baylor College of Medicine. D100 668.16 Regulation of Hepatic CYP3A4 by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. M. Crosby, D.S. Riddick. University of Toronto, Canada. D101 668.17 Protein Abundance of Phase I and II Drug Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhosis Livers. B. Prasad, K. Johnson, G. Xiao, Y. Lai, C. Lee, A.S. Ray, M. Liao, X. Chu, L. Salphati, A. Mathias, W. Humphreys, C.E. Hop, S. Kumer, J.D. Unadkat. University of Washington, Biogen, Bristol-Myers Squibb, Ardea Bio, Gilead Sciences, Takeda Pharmaceuticals International Co., Merck & Co., South San Francisco, Genentech and University of Kansas Medical Center.

669. PHASE I DRUG METABOLISM Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Drug Metabolism Presentation time: 12:30 pm–2:30 pm D102 669.1 Physical Interactions of Cytochrome b5 with Human Cytochrome P450 Enzymes. A.G. Bart, E.E. Scott. University of Michigan. D103 669.2 Validation of Ru(II)-Caged Abiraterone as a Chemical Tool for Controlling CYP17A1 Activity with Visible Light. A. Li, R. Yadav, J.K. White, M.K. Herroon, I. Podgorski, C. Turro, E.E. Scott, J.J. Kodanko. Wayne State University, University of Michigan, The Ohio State University, Barbara Ann Karmanos Cancer Institute. D104 669.3 Interindividual Variability in CYP3A Activity: Influence on CYP3A-Related Herb-Drug Interactions from Selected Natural Health Supplements in Human Liver. S. Deb, A. Bukowska, N. Heo, I. Rajab. Roosevelt University College of Pharmacy. D105 669.4 In Vitro Metabolite Profiling of Sildenafil Based on Metabolomics Approach. S. Kim, J. Jo, O. Kwon, S. Lee. Kyungpook National University, Republic of Korea. D106 669.5 Comparison of Cytochrome P450 3A4 and 3A7 with Azole Inhibitors. M.P. Godamudunage, J.N. Lampe, E.E. Scott. University of Michigan and University of Kansas Medical Center. D107 669.6 Altered CYP19A1 and CYP3A4 Activities Due to Mutations in the Flavin Mononucleotide Binding Domain of Human P450 Oxidoreductase. S.S. Udhane, S. Parween, N. Kagawa, A.V. Pandey. Medical College of Wisconsin Cancer Center, University Children’s Hospital Bern, Switzerland, Nagoya University, Japan and University of Bern, Switzerland.

SUNDAY PHARMACOLOGY D108 669.7 Benzop(a)pyrene in Cigarette Smoke Enhances HIV-1 Replication in Monocytic Cells: Potential Role of Cytochrome P450s and Oxidative Stress. S. Ranjit, N.M. Midde, N. Sinha, S. Kumar. University of Tennessee Health Science Center. D109 669.8 Physical Complexes Formed by CYP1A2 and CYP2B4 Are Associated with Altered P450 Activity. J.P. Connick, J.R. Reed, W.L. Backes. LSUHSC New Orleans. D110 669.9 Characterization of Nefazodone TimeDependent Inhibition of Cytochrome P450 3A. Z. Wang, B.M. Rock, J.T. Pearson, T. Tran, D.A. Rock. Amgen. D111 669.10 Tissue Specific Regulation of CYP26 Enzymes. S. Tripathy, N. Isoherranen. University of Washington. D112 669.11 Tipping the Balance of Hepatic CYP3A4 Activity Through Integrin-Mediated Outside-In and Inside-Out Signaling. K. Jonsson-Schmunk, M. Croyle. University of Texas at Austin. D113 669.12 Cytochrome P450 1A2 N-Terminal Site Directed Mutagenesis: Effects on Lipid Microdomain Localization. C.S. Lott, J.W. Park, J.R. Reed, W.L. Backes. Louisiana State University Health Sciences Center New Orleans. D114 669.13 Effect of Genotype, Age and Gender on Hepatic Abundance of Flavin Monooxigenase 3. M. Xu, D. Bhatt, K. Chaw, C. Yeung, B. Prasad. University of Washington. D115 669.14 Nicotine Metabolism by the Flavin Monooxygenase (FMO) Family of Enzymes. Y. Perez-Paramo, C. Watson, G. Chen, P. Lazarus. Washington State University. D116 669.15 ecoAO: A Simple System for the Study of Drug Metabolism by Human Aldehyde Oxidase. E.M. Paragas, S. Humphreys, J. Min, C. Joswig-Jones, J. Jones. Washington State University. D117 669.16 In Vitro Assessment of Drug Interaction Potential of Licorice Extracts. A. Tonsing-Carter, G. Li, R. van Breemen. University of Illinois at Chicago. D118 669.17 Impact on Drug Responses in Adult Life by Drug Treatment at the Neonatal Age. S. Piekos, L. Chen, X. Zhong. University of Connecticut. D119 669.18 Steroid Metabolism in Human Prostate Cancer Tissue: Effect of CPY17 Inhibitors. S. Deb, M.Y. Chin, S. Pham, H. Adomat, A. Hurtado-Coll, M. Gleave, E.S. Guns. Roosevelt University College of Pharmacy and The Vancouver Prostate Centre at Vancouver General Hospital, Canada. D120 669.19 A Comprehensive Functional Assessment of CES1 Nonsynonymous Variants. X. Wang, N. Rida, J. Shi, H. Zhu. University of Michigan. D121 669.20 Best Practices for Robust LC-MS/MS Quantification of Drug Metabolizing Enzymes and Transporters to Predict Inter-Individual Variability: Case Examples of Hepatic Cytosolic ADHs and ALDH1A1. D. Bhatt, B. Prasad. University of Washington.

670. AUTOPHAGY AND APOPTOSIS IN CANCER Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cancer Pharmacology Presentation time: 12:30 pm–2:30 pm D122 670.1 Globular Adiponectin Induces Endoplasmic Reticulum Stress and Autophagy in Macrophages. H. Oh, N. Tilija Pun, P.K. Raut, E. Kim, A. Khakurel, A. Shrestha, P. Park. Yeungnam University, Republic of Korea. D123 670.2 Autophagy Activation by Leptin Mediates the Growth of Breast Cancer Cells via Estrogen Receptor Signaling: Involvement of AMPK/FoxO3A Axis. P.K. Raut, N. Tilija Pun, E. Kim, A. Khakurel, H. Oh, A. Shrestha, P. Park. Yeungnam University, Republic of Korea. D124 670.3 LXRa Inhibits Autophagy in Hepatocytes Through ATG4B Inhibition. Y. Kim, H. Nam, S. Kim. Seoul National University, Republic of Korea. D125 670.4 Modulation of Autophagy Proteins in Response to a Compound Designed as a Sigma-2 Receptor Agonist Derived from Tamoxifen. C.R. Stang, B.R. Adams, A.D. Faler, B.R. Schuler, D.H. Kinder, P. Sabol, L. Carlston, R.A. Schneider. The University of Findlay and Ohio Northern University. D126 670.5 VJR-TZ-18: Novel Phosphatidylinositol-3Kinase (PI3K) Delta Inhibitor Exerts Antitumor Activity via Induction of Autophagy and Apoptosis in Breast Cancer in Vitro and in Vivo. G. Lalita, G. Jagadeesh Kumar, T. Dinesh, V. Jayathirtha Rao, V. G M. Naidu. NIPER-Hyderabad, India and IICT-Hyderabad, India. D127 670.6 Induction of Autophagy and Apoptosis in Triple-Negative Breast Cancer Cells by LT-IIc, a Type II HeatLabile Enterotoxin. Y. Heakal, S. Girald Berlingeri, J. Hu, M. Federowicz, T.D. Connell, P. Masso-Welch. D’Youville College School of Pharmacy, Jacobs School of Medicine and University at Buffalo. D128 670.7 Cyproterone Acetate Enhances TRAIL-Induced Androgen-Independent Prostate Cancer Cell Apoptosis via Upregulation of Death Receptor 5. L. Chen, D.W. Wolff, Y. Xie, M. Lin, Y. Tu. Creighton University School of Medicine, University of South Carolina School of Medicine and University of Nebraska Medical Center. D129 670.8 Chemotherapeutic Effect of Calcium Sulfide Nanostructures in Non-Small Cell Lung Carcinoma by Intrinsic and Extrinsic Apoptotic Pathways. M.M. Figueroa Rosado, K. Muñoz Forti, G. Arroyo Martínez, T. Vega Carattini, A. Ruiz Rivera, P. Santiago, M.E. Castro, E. Suárez. Pontifical Catholic University, University of Puerto Rico at Ponce, Ponce Health Sciences University and University of Puerto Rico at Mayagüez. D130 670.9 Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Cell Through the Reactive Oxygen Species Mediated Apoptosis. J. Hsiao, P. Chou, M. Sheu. China Medical University, Taiwan and Hungkuang University, Taiwan.

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PHARMACOLOGY SUNDAY D131 670.10 Induction of Apoptosis and Generation of Reactive Oxygen Species by Novel Chalcone Derivatives. C.R. Stang, B.R. Adams, A.D. Faler, B.R. Schuler, A.M. Eichel, M.J. Dick, C.B. Orahood, T.L. Whited, P. Rao, R.W. Dudley, R.S. Khupse, R.A. Schneider. The University of Findlay. D132 670.11 Evaluation of Seahorse XF Cell Mito Stress Test for Detection of Mitochondrial Dysfunction Using Prototypical Mitochondrial Toxicants in the PC-3 Cell Line. J.L. Zhang, C. Krause, R. Ciurlionis, T.L. Sharapova, J. Wilsbacher, S. Ackler, T. Van Vleet, M.J. Liguori. Abbvie and Inc. D133 670.12 RAGE Upregulation Confers a Proliferative Phenotype to PANC-1 Pancreatic Cancer Cells. P. Swami, S. Vetter, E. Leclerc. North Dakota State University.

671. CELL SIGNALING AND CANCER THERAPEUTICS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cancer Pharmacology Presentation time: 12:30 pm–2:30 pm D134 671.1 Tackling Liver Cancer by a Novel Combination Between OSU-2S and Sorafenib. H.A. Omar, M.F. Tolba, J. Hung, T.H. Al-Tel. University of Sharjah, United Arab Emirates, Beni-Suef University, Egypt, Ain Shams University, Egypt and Chia Nan University of Pharmacy and Science, Taiwan. D135 671.2 Peptide Ligand of the Epidermal Growth Factor Receptor for Sensitizing Lung Cancer Cells to Gefitinib. Z.A. ALHamar, T. Andey. MCPHS. D136 671.3 The Role of p90 Ribosomal S6 Kinase in Lung Adenocarcinoma and as a Mediator of the Cytotoxic Effects Induced by Cisplatin. F. Mraiche, N. Abdulrahman. Qatar University, Qatar. D137 671.4 Comparison Study of the Effects of Zerumbone and AG490 in Human Renal Cell Carcinoma on the Activation of the Janus Kinase Pathway and Cell Survival. Z. Walker, A. Duncan, T. Bellomo, K. Budd, A. Polina, J. Hafron, A. BanesBerceli. Oakland University and William Beaumont Hospital. D138 671.5 Aryl Hydrocarbon Receptor/Cytochrome P4501 Pathway Mediates Breast Cancer Stem Cells Expansion Through β-Catenin/Akt Activation and Pten Inhibition. A.O. AlDhfyan, A.R. Alhoshani, H.M. Korashy. King Saud University, Saudi Arabia and King Faisal Specialist Hospital and Research Center, Saudi Arabia. D139 671.6 Non-Cannonical Notch Signaling Pathways Regulate Breast Cancer Stem-Like Cells Function in Triple Negative Breast Cancer. F. Hossain, C. Sorrentino, A. Bilyeu, J. Crabtree, A. Pannuti, T. Golde, B. Osborne, L. Miele. LSUHSC, University of Florida and Umass Amherst. D140 671.7 Reversal of the ERα Negative Receptor in Human Breast Cancer Cells by Dichloro-Napthoquinone Analog. A.G. Robinson, R.L. Copeland. Howard University. D141 671.8 Examining the Role of ARRDC3 in Regulation of PAR1 Trafficking and Signaling in Invasive Breast Carcinoma. A. Arakaki. UC San Diego.

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D142 671.9 Antiproliferative and Antimigratory Effects of Enoxaparin on the Lung Adenocarcinoma A549 Cell Line. A. Alturkistani, V. Power-Charnitsky, N. Ghonem, M.M. Migliore. MCPHS University, Regis College and University of Rhode Island. D143 671.10 GPCRs as Novel Potential Therapeutic Targets in Cancer. P.A. Insel, K. Sriram, S.Z. Wiley, R.P. French, A.M. Lowy. UCSD. D144 671.11 cAMP-Phosphodiesterase PDE4D as a Target for Colon Cancer Therapy. A. Boyd, G. Baskar, T. Petty, A. Keeton, G. Piazza, W. Richter. University of South Alabama. D145 671.12 Berberine Derivatives as Multi-Kinase Inhibitors of MAP Kinase and PI3K Pathways: Molecular Modelling, Molecular Dynamics Simulations, and in Vitro Evaluation. P. Jabbarzadeh Kaboli, P. Ismail, K. Ling. Universiti Putra Malaysia, Malaysia. D146 671.13 The β-Blockers Carvedilol and Nebivolol Inhibit Neoplastic Transformation Through a β2-Adrenergic Receptor Independent Mechanism. K.H. Cleveland, S. Chen, L. Guo, B.T. Andresen, Y. Huang. Western University of Health Sciences and US Food and Drug Administration National Center for Toxicological Research. D147 671.14 A Constitutive Androstane Receptor (CAR) Inhibitor CINPA1 as a Tool to Understand Receptor Structure and Function. M.T. Cherian, S.C. Chai, M.A. Casal, T. Chen. St Jude Children’s Research Hospital and University of Pittsburgh. D148 671.15 Etrasimod, a Novel Sphingosine-1-Phosphate Receptor (S1PR1) Modulator, Lacks Functional Activity at S1P2 Receptors. J.W. Adams, D.J. Unett, X. Chen, I. Gaidarov. Arena Pharmaceuticals, Inc., Beacon Discovery and Inc. D149 671.16 Comparison of the Rexinoids Bexarotene and Pyrimidine-Bexarotene in a Preclinical Model of Lung Carcinogenesis. D. Zhang, A.S. Leal, S. Carapellucci, K. Zydeck, N. Chaaban, M.B. Sporn, C.E. Wagner, K.T. Liby. Michigan State University, Dartmouth Medical School and Arizona State University.

672. ION CHANNELS AND CARDIOVASCULAR PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D150 672.1 Apelin Alters Vasomotor Tone in Cerebral Arteries by Inhibiting Endothelium-Dependent Relaxations That Are Mediated by Activation of Large Conductance, Calcium-Activated K (BKCa) Channels. A. Mughal, C. Sun, S.T. O’Rourke. North Dakota State University. D151 672.2 Activation of Mitochondrial KATP Channels by Diazoxide Stimulates Vascular Repair-Relevant Functions of Human CD34+ Cells by Activating Endothelial Nitric Oxide Synthase. S. Joshi, Y.P. Jarajapu. North Dakota State University.

SUNDAY PHARMACOLOGY D152 672.3 Nitric Oxide Inhibits Functional Coupling Among Endothelial TRPV4 Channels and Limits Vasodilation in Small Pulmonary Arteries. C. Marziano, K. Hong, E.L. Cope, S.S. Sonkusare. University of Virginia. D153 672.4 Muscarinic Cholinergic Receptors Regulate Oscillation of Intracellular Ca2+ in SteroidProducing Adrenocortical Carcinoma Cells. H. Sharthiya, N. Surachaicharn, Y. Shams, M. Arshad, P.G. Kopf, L.M. Malaiyandi, K.E. Dineley. Midwestern University. D154 672.5 The Cellular Mechanism of Bitter Taste Receptor Mediated Relaxation of Rat Aorta. W. Xin, Q. Chen. Southwest University, People’s Republic of China. D155 672.6 Functional Upregulation of STIM-1/Orai-1Mediated Store-Operated Ca2+ Entry Contributing to the Aortic Remodeling and Hypertension Development by Chronic EtOH Consumption. G.S. Bomfim, I. Méndez-López, J.A. ArranzTagarro, D.C. Musial, A.A. Carbonel, J.F. Padín, A.G. García, A.A. Jurkiewicz, N.H. Jurkiewicz. Federal University of São Paulo (UNIFESP)—Brazil, Brazil, Universidad Autónoma de Madrid (UAM)—Spain, Spain, Universidad Autónoma de Madrid (UAM) and Madrid—Spain, Spain. D156 672.7 Role of Transient Receptor Potential Canonical 5 (TRPC5) Channels in Vascular Tone Regulation. C. Liang. The Chinese University of Hong Kong, People’s Republic of China. D157 672.8 Characterisation of Mechanisms of Relaxation Induced by Omega-3 Polyunsaturated Fatty Acids (n-3 PUFA) EPA and DHA in Rat Aorta and Mesenteric Arteries: A Novel Role for IKCa and TRPV4 Channels in DHA Mediated Relaxation. A.J. McNeish, G.S. Cottrell, R. Limbu. The University of Reading, United Kingdom.

673. DIABETES AND CARDIOVASCULAR PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D158 673.1 Altered Spinophilin Interactions in the Pancreas of a Leptin Receptor Mutant (db/db) Model of Obesity. K.C. Stickel, D.S. Watkins, M.C. Edler, S. Dharmarajan, T.L. Belecky-Adams, N.F. Berbari, T.L. Mastracci, A.J. Baucum II. IUPUI, Indiana University School of Medicine and Indiana Biosciences Research Insitute. D159 673.2 Cardiac HMGB1/TLR4 Activation in PreType 2 Diabetes: A Potential Mechanism Triggering Diabetic Cardiovascular Complications. E. Vargas, Y. Li, M. CarrilloSepulveda. NYIT College of Osteopathic Medicine. D160 673.3 Hyperglycemia-Induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-Mediated Suppression of RPI3 in Diabetic Rats. H. Li, M.G. Irwin, Z. Xia. The University of Hong Kong, Hong Kong, Affiliated Hospital of Guangdong Medical University, People’s Republic of China.

D161 673.4 Myo-Inositol Concentration Is Strongly Reduced in the Renal Cortex of STZ-Diabetic Rats. M.C. Fonteles, D.B. Heimark, P.N. Uchoa, C.P. Aquino, N.R. Nascimento, C.F. Santos. Ceara State University, Brazil. D162 673.5 Structure Based Drug Design with Diabetic Retinopathy and Rage. S. Sriramoju, D. Evangelista, K. Goetz. Ardsley High School and NIH/NEI. D163 673.6 Mid-Term Exposure to Prednisone Is Less Detrimental Than Short-Term Dexamethasone on Glucose Homeostasis in Rats. N.X. Ribeiro, D.N. Melo, J.R. Sanches, L.M. França, A.G. Cappelli, A. Rafacho, I.C. Abrau, A.M. Paes. Federal University of Maranhão, Brazil and Federal University of Santa Catarina, Brazil. D164 673.7 SGLT1 Inhibition Has Modest Gastrointestinal Consequences in Mice and Rats. P.J. Hornby, F. Du, S. Hinke, N. Wallace, C. Cavanaugh, C. Bender, M. Jennis, Y. Liang, M. Gaul, G. Kuo, J. Lenhard. Janssen R&D. D165 673.8 Novel RAGE Antagonist, FPS-ZM1, Reverses Mesenteric Arteriolar Remodeling in Type 2 Diabetic db/db Mice. H. Labazi, P. McCallinhart, I. Sunyecz, A. Trask. The Research Institute at Nationwide Children’s Hospital and The Ohio State University. D166 673.9 Downregulation of Histone Deacetylase 9 (HDAC9) Is Associated with Vascular Calcification in Diabetic Mice. S.A. Benerofe, M. Carrillo-Sepulveda. NYIT College of Osteopathic Medicine. D167 673.10 The Aortic Function of Male UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rats: Possible Involvement of Potassium Channels. F. Akther, S. Shaligram, M.D. Karimi, J.L. Graham, K.L. Stanhope, P.J. Havel, R. Rahimian. University of the Pacific and University of California. D168 673.11 Targeting Cathepsin K to Promoted Diabetic Wound Healing. S. Nair, R. Guo, R. Nair, C. Zgheib, J. Xu, K.W. Liechty. University of Wyoming, Nutriwyo LLC and University of Colorado. D169 673.12 Dantrolene and Nimodipine Reduce Arterial Tone Synergistically in Aortic Rings from Type-1 Diabetic Rats. M. Roman, S. Alemar, J. Matias, M. Torres-Grajales, R. Zack, M. Morales, H. Torres, M. Crespo. University of Puerto RicoSchool of Medicine, Puerto Rico. D170 673.13 Functional Changes in Vascular Reactivity to Adenosine Receptors Activation in Type I Diabetic Mice. H. Labazi, B. Teng, S.J. Mustafa. Nationwide Children’s Hospital and West Virginia University. D171 673.14 Treatment with Captopril Enhances the Vascular Relaxation Induced by the Angiotensin II Type 2 Receptor (AT2R) Agonist CGP42112 in Diabetic Rats. R. Sabra. American University of Beirut, Lebanon. D172 673.15 FOXO1 Overactivation via Enhancing CD36 Exacerbates Myocardial Ischemia Reperfusion Injury in Diabetic Rats. D. Yan, Z. Xia. The University of Hong Kong, Hong Kong. D173 673.16 Critical Role for Adenylyl Cyclase 5 on L-Type CaV1.2 Channel Potentiation and Vasoconstriction During Diabetic Hyperglycemia. A.U. Syed, M.A. Nystoriak, M. Prada, M. Nieves-Cintrón, M.F. Navedo. University of CaliforniaDavis and University of Louisville.

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674. VASCULAR PHARMACOLOGY OF HEMOSTASIS AND THROMBOSIS Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Cardiovascular Pharmacology Presentation time: 12:30 pm–2:30 pm D174 674.1 A Novel Role of Lassbio-788 in Inhibiting NFκB Mediated Signaling in Platelet of Hypercholesterolemic Rats. F.C. Brito, N.A. Motta, G.F. Lima, R. Lopes, E.J. Barreiro, A.E. Kummerle. Universidade Federal Fluminense, Brazil, Universidade Federal do Rio de Janeiro, Brazil and Universidade Federal Rural do Rio de Janeiro, Brazil. D175 674.2 Neutralization of Unfractionated Heparin (UFH) and a Bioengineered Heparin Dodecasccharide (12-mer) by Protamine Sulfate. A. Kouta, R. Duff, D. Hoppensteadt, W. Jeske, S. Abro, J. Fareed. Loyola Hemostasis & Thrombosis. D176 674.3 Anticoagulant Profiling of a Generic Enoxaparin and Its Comparison with Its Branded Version. S. Abro, D. Hoppensteadt, J. Fareed. Loyola Hemostasis & Thrombosis. D177 674.4 Comparative Anticoagulant Effects of Recombinant Thrombomodulin, Antithrombin, and Unfractionated Heparin, Hematological Implications. Z. Siddiqui, J. Fareed, P. Aggarwal, O. Iqbal, D. Hoppensteadt, S. Abro. University of Illinois and Loyola Hemostasis & Thrombosis. D178 674.5 Terminalia Methanol Extracts Inhibit the Amidolytic Activity of Human Activated Factor XII (Hageman Factor). H. Madkhali, A. Alharbi, Z. Ali, I. Khan, Z. ShariatMadar. Prince Sattam Bin Abdulaziz University, Saudi Arabia and University Of Mississippi. D179 674.6 RGS10 Serves as a Braking System for Platelet Hyperactivity. N.R. Hensch, Z.A. Karim, H. Qasim, F.T. Khasawneh. Western University of Health Sciences. D180 674.7 Withdrawn. D181 674.8 Novel Peptide Micellar Nanoformulation for Treatment of thrombotic Complications of Sepsis. M. Bae, L. Rusu, M. Castellon, X. Du, H. Onyuksel, R.D. Minshall. College of Medicine, University of Illinois at Chicago, College of Pharmacy and University of Illinois at Chicago. D182 674.9 A Prospective, Open Label Study to Evaluate the Pharmacokinetics of Dabigatran in Patients with NonValvular Atrial Fibrillation and Severe Renal Impairment Who Are Receiving Dabigatran Etexilate (75 mg Twice Daily). J. Martin, H. Esmaeili, R.C. Manuel, M. Petrini, S. Wiebe, H. Maas. Sharpe Strumia Research Foundation, Staburo GmbH, Germany, Boehringer Ingelheim Pharmaceuticals, Inc and Boehringer Ingelheim Pharma GmbH & Co. KG, Germany. D183 674.10 Effect of an Active Phosphatidylserine Species on Antigen-Specific Tolerance Induction Toward Factor VIII in Hemophilia a Mice. F.C. Yau, S.V. Balu-Iyer. University at Buffalo.

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D184 674.11 Slounase, a Snake Venom Hemocoagulase Combined with FXa, Enhances Hemostasis and Limits Bleeding in Both Normal and Hypocoagulant Conditions. R. Adili, X. Dai, B.X. Li, M. Holinstat. University of Michigan and Lee’s Pharmaceutical Holdings Limited, Hong Kong. D185 674.12 Loss of Rnase1 Produces Coagulation Abnormalities in Mice. E.R. Garnett, R.T. Raines. University of Wisconsin-Madison. D186 674.13 Polyphosphate-Conjugated Silica Nanoparticles (PolyP-SNPs) Attenuate Bleeding After Tail Amputation. K. Ploense, D. Kudela, S. Hammond, G. Stucky, T. Kippin. Cayuga Biotech and UC Santa Barbara. D187 674.14 Antithrombotic Activity of New Potassium Salt 2-[3-Bromine-1-(Thietanil-3)-1,2,4-Triazolil-5-Thio]acetic Acid. A.V. Samorodov, F.K. Kamilov, E.E. Klen, F.A. Khaliullin, A.R. Khalimov. Bashkirian State Medical University, Russian Federation. D188 674.15 Plasma Nucleosomes Correlate with Markers of Inflammation and Thrombosis in Patients with Sepsis-Associated Coagulopathy. A.T. Walborn, P. Patel, D. Hoppensteadt, M. Mosier, S. Statz, M. Rondina, J. Fareed. Loyola University Chicago and University of Utah. D189 674.16 Chronic Deep Vein Thrombosis: Pentadecapeptide BPC 157 Effect on Vein Thrombi. M. Siroglavic, J. Vukojevic, D. Drmic, A. Tvrdeic, S. Seiwerth, P. Sikiric. School of Medicine and University of Zagreb, Croatia. D190 674.17 Polyphenol Rich Extract of Syzygium cumini (L.) Skeels Leaves Decreases Platelet Aggregation and Inhibits Reductase Activity of Protein Disulfide Isomerase. S.A. da Silva, H.R. Sousa, R. Gaspar, J. Fontelles, A.E. Trostchansky, A. Paes. Federal University of Maranhão, Brazil, UFMA, Brazil and Republic University of Uruguay, Uruguay. D191 674.18 Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents. W. Jeske, O. Bouchard, D. Hoppensteadt, P. Maia, A. Silva De Castro, E. Kumar, N. Gular, D. Kahn, J. Walenga, Y. Yao, F. Jawed. Loyola University Chicago, Ronnsi Pharma, People’s Republic of China. D192 674.19 A Polydeoxynucleotide Derived Drug Defibrotide Inhibits Nucleosome Generation in Whole Blood. Implications in the Management of VOD. J. Fareed, D. Hoppensteadt, A. Walborn, T. Phan, S. Spatz, J. Walenga, W. Jeske. Loyola University Chicago. D193 674.20 Genetic Variation in 12-Lox Regulates the Efficacy Of ω-3 and ω-6 Fatty Acids to Suppress Platelet Activation. S. Shil, M. Hawley, C. Li, M. Holinstat. University of Michigan. D194 674.21 Novel Antiplatelet Role for a Protein Disulfide Isomerase-Targeted Peptide: Evidence of Covalent Binding to C-Terminal CGHC Redox Motif. R.S. Gaspar, H.R. Sousa, E. Sena, S.A. Da Silva, J. ‘de Lima Fontelles, T. Araujo, D. Fries, A. Azevedo-Santos, F. Laurindo, A. Trostchansky, A. Paes. Federal University of Maranhão, Brazil, University of Sao Paulo, Brazil and University of the Republic, Uruguay.

SUNDAY PHARMACOLOGY

675. CLINICAL PHARMACOLOGY I Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Translational and Clinical Pharmacology Presentation time: 12:30 pm–2:30 pm D195 675.1 Identification of a Novel MetforminMethylglyoxal Imidazolinone Metabolite in T2DM Patients and Its Potential Roles in Alleviating T2DM Complications. T.L. Hargraves, O.R. Kinsky, T.J. Monks, S.S. Lau. Wayne State University and University of Arizona. D196 675.2 12-HETrE Exerts Its Antithrombotic Effects Through the Prostacyclin Receptor. B. Tourdot, Z. Isingizwe, R. Adili, T. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. D197 675.3 Histone Modification Is a Novel Epigenetic Mechanism to Up-Regulate Human Blood-Brain Barrier Transporters. D. You, X. Wen, A. Morris, J.R. Richardson, L.M. Aleksunes. Rutgers University and Northeast Ohio Medical University. D198 675.4 Novel Characterization of Docohexanoic Acid and Its 12-LOX Products, 11-HDHE and 14-HDHE on Human Blood Platelets. D.D. Craven, N. Edokobi, M. Hawley, T. Holman, M. Holinstat. University of Michigan Medical School and University of California- Santa Cruz. D199 675.5 11/14-Oxy-DPA, the 12-LOX Derived Metabolites of DPA, Inhibit Platelet Activation Through the cGMP-PKG Signaling Pathway. J. Yeung, N. Edokobi, M. Hawley, D. Craven, C. Li, T.R. Holman, M. Holinstat. University of Michigan and University of California Santa Cruz. D200 675.6 Prostaglandin E2 (PGE2) Levels as a Predictor of Type 2 Diabetes Control in Human Subjects: A Cross-Sectional View of Initial Cohort Study Data. R. Fenske, A. Weeks, A. Brill, R. Nall, S. Pabitch, M. Punt, M. Daniels, S. Blaha, D.B. Davis, M. Kimple. University of Wisconsin—Madison. D201 675.7 Effect of Sevoflurane Plus Ondansetron and Ranitidine vs. Propofol and Remifentanil for the Prevention of Post-Operative Nausea and Vomiting. S.M. Lynch, O.L. Tulp, G.P. Einstein. USAT Montserrat, Montserrat. D202 675.8 Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study. J. Tank, K. Heusser, O. Holz, M. May, J. Brinkmann, A. Diedrich, T. Framke, A. Koch, A. Grosshennig, F.C. Sweep, W. Koch, N. Krug, J. Jordan, J. Hohlfeld. Institute for Clinical Pharmacology, Hannover Medical School, Germany, Fraunhofer Institute for Toxicology and Experimental Medicine, Germany, Hannover Medical School, Germany, Vanderbilt University School of Medicine and Radboud University Medical Center, Netherlands.

676. CARDIOVASCULAR PRECLINICAL PHARMACOLOGY Poster Sun. 9:00 am—McCormick Place Convention Center, Hall F Translational and Clinical Pharmacology Presentation time: 12:30 pm–2:30 pm D203 676.1 Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)-Epicatechin on Cardiometabolic Endpoints. F. Villarreal, A. Moreno-Ulloa, T. Ciaraldi, B. Best, I. Ramirez-Sanchez, G. Ceballos, S. Dugar, G. Schreiner, R. Henry. UCSD School of Medicine, UCSD School of Pharmacy, IPN ESM, Mexico and Cardero Therapeutics Inc. D204 676.2 Treatment with the Soluble Guanylate Cyclase Stimulator IW-1973 Reduces N-Terminal Pro B-Type Natriuretic Peptide and Improves Heart Function in Rat Models of Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction. C. Shea, G. Liu, R. Sarno, E. Lonie, D. Zimmer, M. Currie, J. Masferrer. Ironwood Pharmaceuticals. D205 676.3 Pretreatment with Probenecid Downregulates Kidney Pendrin Expression and Potentiates Hydrochlorothiazde Diuresis in Rat. S. Barone, J. Xu, K. Zahedi, M. Soleimani. University of Cincinnati, Research Services and VA Hospital. D206 676.4 Switching Off TRPC6 Signaling: A New AntiEdemagenic Strategy. M. Amin, H. Piplani, T. Sharma, D. Mehta. University of Illinois at Chicago. D207 676.5 ATP-Sensitive K+ Channels in Smooth Muscle Cells from Rat Mesenteric Lymph Vessels. B.R. Garner, A.J. Stolarz, T.W. Fletcher, N.J. Rusch. University of Arkansas for Medical Sciences. D208 676.6 The Fungicidal Potential of Dimethyloxaglycine (DMOG) in Infected Bone Marrow Macrophages of C57 BL6-J Mice. A. Lopez, W. Buesing, J. Tweedle, G. Deep. University of Puerto Rico at Ponce and University of Cincinnati College of Medicine.

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PHYSIOLOGY SUNDAY

Physiology 677. ATHEROSCLEROSIS/THROMBOSIS/PLATELETS Poster (Sponsored by: The Microcirculatory Society)

Poster

Sun. 9:00 am—McCormick Place Convention Center, Hall F

(Sponsored by: The Microcirculatory Society)

Presentation time: 12:45 pm–3:00 pm E157 677.1 Tetramethylpyrazine Reduces Intra-Platelet Calcium via Suppressing the SGK1/STIM1/Orai1 Pathway. Z. Wang, H. Cang, S. Gao, L. Han, H. Wu. Second Affiliated Hospital, Henan University of Traditional Chinese Medicine, People’s Republic of China. E158 677.2 YiqiHuoxue Decoction and Its Constituents Inhibit the Activation of Platelets and Thrombosis for the Prevention and Treatment of Cardiovascular Diseases. H. Wu, Z. Lei, S. Gao, L. Han. Henan University of Traditional Chinese Medicine, People’s Republic of China. E159 677.3 Effects of GLA Precursors Added to Atherogenic Diet on Platelet Insulin Sensitivity, Plasminogen Activator Activity and Atherogenic Plaque Development in Rabbits. E.L. Beard, S. Edupuganti. Loyola University. E160 677.4 Functional Analyses of Reticulated Platelets. M. Hayman, P. Armstrong, M. Chan, T. Warner. William Harvey Research Institute, United Kingdom. E161 677.5 Vascular Activation and Development of Carotid Intima-Media Thickness in Postmenopausal Women Is Influenced by Pregnancy History. V.M. Miller, V.D. Garovic, M.M. Mielke, K.R. Bailey, B. Lahr, W.M. White, M. Jayachandran. Mayo Clinic. E162 677.6 Fibrinogen and Its Soluble Fibrin as Mediators of Erythrocyte Aggregation. S. WeberFishkin, R.A. Clark, D. Galanakis, B.A. Irizarry, A.L. Young, M.(. Frame. Stony Brook University. E163 677.7 The Effects of Membrane Cholesterol on the Mechanics of Vascular Smooth Muscle Cell. Z. Hong, J. Childs, H. Sanyour. University of South Dakota. E164 677.8 Substrate Properties Affect Thrombin Generation Kinetics. S. Laljee, D.A. Rubenstein, W. Yin. Stony Brook University. E165 677.9 Platelet Functional Effects Induced by Fluorescent Labeling via Transgenic- and Antibody-Based Approaches. Q. Da, R. Rumbaut. Michael E. DeBakey VA Medical Center and Baylor College of Medicine. E166 677.10 Circulating Mitochondrial (mt) DNA Fragments as Precursors of Inflammation in Early Stages of Atherogenesis. M.V. Ruchko, V.M. Pastukh, S. Sukhanov, O.M. Gorodnya, S.D. Danchuk, M.N. Gillespie. University of South Alabama College of Medicine and University of Missouri School of Medicine. E167 677.11 Apoptosis and Autophagy in Human Vein Grafts Replacing Occluded Coronary Arteries in Atherosclerosis. H.E. Bortier, M. Kockx, G. De Meyer. University of Antwerp, Belgium and AZ Middelheim, Belgium.

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678. ANGIOGENESIS/MICROVASCULAR REMODELLING/INJURY AND REPAIR

Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E168 678.1 Activator of G-Protein Signaling 8 Is Involved in VEGF-Induced Choroidal Angiogenesis. H. Hayashi, A.A. Mamun, M. Sakima, M. Takeyama, R. Yagasaki, M. Zako, T. Nakahara, M. Sato. Aichi Medical University, Japan and Kitasato University School of Pharmaceutical Sciences, Japan. E169 678.2 Recovery of Vasomotor Control in Microvascular Resistance Networks of Regenerating Skeletal Muscle. C.A. Fernando, D.W. Cornelison, S.S. Segal. University of Missouri. E170 678.3 Exercise Recovers Loss of Microvessel Density due to Lowered Nitric Oxide Bioavailability. K. Branyan, M. Ashman, C. Pitzer, P. Chantler, M. Olfert. West Virginia University. E171 678.4 Mechanoadaptation, Arteriogenesis, and Vascular Reactivity in Male and Female C57Bl/6 Mice. T.R. Cardinal, L.L. Burckhardt, M.T. Chu, A.M. Krall, R.R. Gallagher, A.J. Bynum. Cal Poly. E172 678.5 Absence of Endothelial Estrogen Receptor Alpha Decreases Stiffness and Induces Outward Hypertrophic Remodeling in the Resistance Arteries of Male Mice Fed a Western Diet. F.I. Ramirez-Perez, C. Manrique-Acevedo, J. Padilla, V.J. Vieira-Potter, A.R. Annaya, B.J. Barron, D. Chen, D. Haertling, C. Declue, J.R. Sowers, L.A. Martinez-Lemus. University of Missouri. E173 678.6 The Role of Leptin in Coronary Collateral Growth. K. Graham, V. Ohanyan, M. Enrick, C. Kolz, W.M. Chilian, L. Yin. Northeast Ohio Medical University. E174 678.7 TRPV4 Channels Regulate Vascular Integrity Through Stabilization of VE-Cadherin Junctions. H.C. Cappelli, V. Amin, P. Sharma, A.K. Kanugula, R.K. Adapala, J. Meszaros, S.K. Paruchuri, C.K. Thodeti. Northeast Ohio Medical University (NEOMED) and University of Akron. E175 678.8 Development of the ex Vivo Mouse Mesometrium Model to Investigate Multicellular Dynamics During Angiogenesis. A.D. Suarez-Martinez, D. Kaplan, K. Huang, S. Meadows, S. Bierschenk, M. Sperandio, W.L. Murfee. Tulane University and Ludwig-Maximilians Universität, Germany. E176 678.9 Microvascular Content and Insulin Sensitivity Within Skeletal Muscle and Adipose Tissue Differs Between Male and Female Mice on a High-Fat Diet. G. Abdifarkoosh, M. Rudnicki, E. Roudier, T.L. Haas. York University, Canada. E177 678.10 Microfluidic Model of Angiogenic Remodeling at Blood Vessel Bifurcations. E. Akbari, G.B. Spychalski, K.K. Rangharajan, S. Prakash, J.W. Song. The Ohio State University. E178 678.11 Interleukin-10 (IL-10) Enhances Wound Healing of Cutaneous Flaps Following Ischemia Reperfusion Injury (IRI). Y. Tang, T. Lian. LSU Health Science Center.

SUNDAY PHYSIOLOGY E179 678.12 Endothelial Foxo1 and Foxo3a Synergistically Repress Skeletal Muscle Vascular Growth and Blood Flow Recovery in a Mouse Model of Hind Limb Ischemia. E. Nwadozi, M. DeCiantis, T. Haas. York University, Canada. E180 678.13 Evaluation of Sex Differences in Vascular Density in a Rodent Model of Traumatic Brain Injury Using Steady-State Contrast Enhanced Magnetic Resonance Imaging. J.N. Mayo, D. Wright, R. Phillips, T. O’Brien, S. Shultz. Western State Colorado University and University of Melbourne, Australia. E181 678.14 Phenotypic Sexual Dimorphism of Micro- And Macrovascular Endothelium with Respect to Size, Growth, and Wound Repair. V.H. Huxley, S. Sieveking, S. Kemp, C. Schramm. University of Missouri—Columbia.

679. INFLAMMATION/LEUKOCYTEENDOTHELIUM INTERACTIONS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E182 679.1 Neutrophil Extracellular Traps Contribute to Endothelial Barrier Dysfunction During Sepsis. J.E. Meegan, R.S. Beard; Jr, X. Yang, J.J. Reynolds, D.C. Coleman, M. Jannaway, S.Y. Yuan. University of South Florida. E183 679.2 Super Resolution Imaging Visualized the Nanoscaled Localization of Integrin Activation During Human Neutrophil Arrest. Z. Fan, W.B. Kiosses, K. Ley. La Jolla Insititue for Allergy and Immunology, The Scripps Research Institute and University of California San Diego. E184 679.3 Endothelial Mineralocorticoid Receptors Contribute to Sex-Dependent Vascular Inflammation and Plaque Vulnerability in Atherosclerosis. M. Moss, S. Iyer, D. Engelbertsen, V. Serbulea, A.H. Lichtman, N. Leitinger, I.Z. Jaffe. Tufts Medical Center, Brigham and Women’s Hospital and University of Virginia School of Medicine. E185 679.4 Pro-Inflammatory Cytokines and the Marrow Microenvironment. S. Lee, R. Prisby. University of Texas Arlington. E186 679.5 Chlorinated Lipids Elicit Neutrophil-Endothelial Interactions in Mesenteric Microcirculation. H. Yu, M. Wang, D.Z. Wang, T. Kalogeris, D.A. Ford, K.J. Ronald. University of Missouri and Saint Louis University. E187 679.6 Prunella vulgaris Attenuates Diabetic Renal Injury by Suppressing High Glucose-Induced Mesangial Fibrosis and Inflammation. S. Namgung, J. Yoon, B. Han, E. Choi, M. Hong, Y. Lee, D. Kang, H. Lee. Wonkwang University, Republic of Korea. E188 679.7 Endothelial Cell Barrier Protein Expression Differs by Organ and Sex. S.S. Kemp, V.H. Huxley, C. Schramm, S.W. Sieveking. University of Missouri. E189 679.8 IGF-1 Receptor on Leukocytes Potentiates Western Diet-Induced Inflammatory Response and Progression of Atherosclerosis in ApoE-Deficient Mice. M. Wang, Y. Higashi, D. Wang, H. Yu, P. Delafontaine, R. Korthuis. University of Missouri.

E190 679.9 Oncostatin M Induces Barrier Dysfunction in Human Brain Microvascular Endothelium via SnailDependent Repression of TAMPs. T.S. Wertz, B.A. Hoettels, K. Tawara, J.T. Oxford, C.L. Jorcyk, R.S. Beard Jr. B o i s e State University.

680. ISCHEMIA-REPERFUSION/FREE RADICAL BIOLOGY Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E191 680.1 Increased Cysteine Sulfonation of Complex I, Complex III, and Aconitase Is Associated with Mitochondrial Dysfunction in the Post-Ischemic Heart. P.T. Kang, C. Chen, P. Lin, L. Zhang, Y. Chen. Northeast Ohio Medical University and The Ohio State University. E192 680.2 Endothelium Protects Smooth Muscle from Oxidative Stress in Skeletal Muscle Resistance Arteries. S.Y. Sinkler, S.S. Segal. University of Missouri. E193 680.3 Angiotensin II-Preconditioning Is Associated with Increased PKCε/PKCδ Ratio and Prosurvival Kinases in Mitochondria. R. Nuñez, S. Javadov, N. Escobales. University of Puerto Rico School of Medicine. E194 680.4 Interleukin-12 Disruption Protects Myocardium from Ischemia-Reperfusion Injury in Type 2 Diabetic Mice. V. Mali, W. Tennant, S. Haddox, K. Matrougui, S. Belmadani. Department of Physiology and Eastern Virginia Medical School. E195 680.5 Cathepsin B Mediated Degradation of Jejunal Epithelial Tight Junction Proteins During the Early Stage of Hemorrhagic Shock. N.P. Klein, A. Courelli, G. SchmidSchoenbein. University of California San Diego and HammLippstadt University of Applied Sciences, Germany. E196 680.6 Chloropalmitate Increases Solute Permeability and VE-Cadherin Internalization in Human Microvascular Endothelial Cells. T. Kalogeris, T.M. Birkhead, D. Ford, R. Korthuis. University of Missouri and Saint Louis University. E197 680.7 Cardioprotective Effects of Hydroalcoholic Extract of Terminalia Capatta in Isolated Perfused Rat Hearts. J.D. Torres-Tirado, G. Pérez, E. Sanchez, A. Estrada, A. Zacarias, A. Leon. Universidad Autonoma de San Luis Potosí, Mexico.

681. MICROVASCULAR CELL SIGNALLING PATHWAYS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E198 681.1 Capillary Endothelial Gq Protein-Coupled Receptors and PIP2 Toggle Signaling Between TRPV4 and Kir2 Channels in the Brain. O.F. Harraz, T.A. Longden, F. Dabertrand, M.T. Nelson. University of Vermont.

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PHYSIOLOGY SUNDAY E199 681.2 Increased Propensity for Cerebral Microhemorrhages in a IGF-1 Deficient Mouse Model of Accelerated Vascular Aging. S. Tarantini, M. ValcarcelAres, A. Yabluchanskiy, Z. Springo, G. Fulop, N. Ashpole, T. Gautam, C. Giles, J. Wren, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center— Reynolds Oklahoma Center on Aging Research, University of Mississippi and Oklahoma Medical Research Foundation. E200 681.3 Treatment with the Mitochondrial Antioxidant Peptide SS-31 Rescues Neurovascular Coupling Responses and Cerebrovascular Endothelial Function and Improves Cognition in Aged Mice. S. Tarantini, M. Valcarcel-Ares, A. Yabluchanskiy, G. Fulop, P. Hertelendy, T. Gautam, E. Farkas, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research and University of Szeged, Hungary. E201 681.4 Neurovascular Uncoupling Predicts Cognitive Decline and Gait Abnormalities in a Clinically Relevant Mouse Model of Whole Brain Irradiation. A. Yabluchanskiy, S. Tarantini, P. Hertelendy, M. Valcarcel-Ares, T. Gautam, E. Farkas, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research and University of Szeged, Hungary. E202 681.5 Interaction of Obesity and Nrf2 Deficiency Accelerates Cerebromicrovascular Aging and Impairs Neurovascular Coupling Responses. M.N. Valcarcel-Ares, S. Tarantini, P. Hertelendy, Z. Tucsek, T. Gautam, T. Kiss, R. De Cabo, E. Farkas, Kinter, W. Sonntag, A. Csiszar, Z. Ungvari. University of Oklahoma Health Sciences Center—Reynolds Oklahoma Center on Aging Research, NIA, University of Szeged, Hungary and Oklahoma Medical Reseach Foundation. E203 681.6 Administration of Prostacyclin Mediates Cutaneous Vasodilation But Not Sweating in Young and Older Females: Roles for Nitric Oxide and KCa Channels. N. Fujii, B.D. McNeely, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan. E204 681.7 Endothelial Mitochondria Regulates Local Calcium Signalling in Mesenteric Arteries from Mice. F. Toussaint, D. Béziau, C. Charbel, A. Blanchette, G. Mayer, P. Comtois, J. Ledoux. Montreal Heart Institute, Canada and Université de Montréal, Canada. E205 681.8 Spatio-Temporal Analysis of Intracellular and Intercellular Calcium Signaling in Microvascular Endothelial Cell Tubes. M.J. Socha, E. Billings, T.L. Domeier, R.S. Balaban, S.S. Segal. The University of Scranton, National Institutes of Health, University of Missouri-Columbia and Dalton Cardiovascular Research Center. E206 681.9 Smooth Muscle α1-Adrenergic Receptor Activation Initiates a Negative Feedback Mechanism That Involves Ca2+ Influx Through Endothelial TRPV4 Channels. K. Hong, E.L. Cope, Marziano, S.K. Sonkusare. University of Virginia. E207 681.10 Signal Inference: A Method to Locate and Track Calcium Waves with Statistical Confidence. E. Billings, M.J. Socha, T.L. Domeier, R.S. Balaban, S.S. Segal. National Institutes of Health, The University of Scranton, University of Missouri-Columbia and Dalton Cardiovascular Research Center. E208 681.11 Essential Role for Interleukin-12 in Microvascular Endothelial Dysfunction in Type 2 Diabetes. E. Radwan, V. Mali, S. Haddox, M. Trebak, S. Belmadani, K. Matrougui. EVMS, Assiut University, Egypt and Penn State.

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E209 681.12 Calreticulin Localized to the Myoendothelial Junction Mediates Heterocellular Communication in Resistance Arteries. L.A. Biwer, M.E. Good, K. Hong, R. Patel, N. Agrawal, R. Looft-Wilson, S. Sonkusare, B.E. Isakson. University of Virginia and College of William and Mary. E210 681.13 Contractile Function of Coronary Arterioles Is Impaired in Adiponectin-Deficient Mice. J. Bramy, K. Gorman, M. Delp, P. Ghosh, K. Hotta, B. Behnke, J. Delp. Florida State University and Kansas State University.

682. TISSUE MICROVESSEL INTERACTIONS/ EXTRACELLULAR MATRIX Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E211 682.1 Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces. J. Dale, L. Krishnan, K. Aliaj, J. Beare, J. Weiss, J. Hoying. Cardiovascular Innovation Institute and University of Utah. E212 682.2 Impact of Endothelial-Specific FoxO1 Depletion on the Development of Metabolic Dysfunction in Obesity. M. Rudnicki, G. Abdifarkosh, E. Roudier, E. Nwadozi, T. Haas. York University, Canada. E213 682.3 ‘Fibulin-4 Is Important for Maintaining Vascular Wall Integrity in Large but Not Small Vessels. C.M. Halabi, M. Lin, T.J. Broekelmann, M. Chu, R.P. Mecham. Washington University School of Medicine and Thomas Jefferson University. E214 682.4 The Extracellular Matrix Proteoglycan Decorin Is Upregulated by Endothelial Cells During Inflammation and Contributes to Blood-Brain Barrier Dysfunction. B.A. Hoettels, T.S. Wertz, D.E. Birk, J.T. Oxford, R.S. Beard Jr. B o i s e State University and University of South Florida.

683. LYMPHATIC AND VENULAR FUNCTION Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E215 683.1 Lymphatic Vessel-Independent Lymph Flow Pattern from the Peri-Nodal Adipose Tissue to the Lymph Node. Y. Lin, S. Liao. University of Calgary, Canada. E216 683.2 Alterations to Venular Function in Skeletal Muscle with Metabolic Syndrome. K. Lemaster, Z. Farid, D. Jackson, D. Goldman, R. Brock, J. Frisbee. University of Western Ontario, Canada and West Virginia University. E217 683.3 Adipose Tissue VEGF-D Overexpression Increases Lymphatic Vessel Density and Protects Against Inflammation and Insulin Resistance in Obesity. G.M. Lammoglia, S.E. Barajas, A.J. Reyna, J.M. Rutkowski. Texas A&M College of Medicine.

SUNDAY PHYSIOLOGY E218 683.4 Anti-Ascites Adaptation of Liver to Sinusoidal Hypertension. R.M. Dongaonkar, G.A. Laine, C.M. Quick, R.H. Stewart. Texas A&M University. E219 683.5 Ileal Smooth Muscle Thickness Is Greater in Young Obese Zucker Rats. A.R. Burgess, A.N. Trujillo, M. Barter, J.W. Breslin. University of South Florida. E220 683.6 Thoracic Duct Lymph Suppresses the Release of Inflammatory Mediators from Macrophages in Vitro. R. Castillo, L. Hodge. University of North Texas Health Science Center.

684. MICROCIRCULATION Poster (Sponsored by: APS Cardiovascular Section) (Cosponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E221 684.1 Ginsenoside Rb1 Protects Against Ischemia/ Reperfusion-Induced Myocardial Injury via Energy Metabolism Regulation Mediated by RhoA Signaling Pathway. J. Han, Y. Cui, C. Pan, L. Yan, B. Hu, X. Chang, Y. Liu, K. Sun, Q. Li, J. Fan. Peking University Health Science Center, People’s Republic of China. E222 684.2 Vasodilatory Function in Human Skeletal Muscle Arteries with Advancing Age: Role of Adropin. O. Kwon, R. Andtbacka, J. Hyngstrom, R. Richardson. University of Utah. E223 684.3 Enhanced Myogenic Response of Cerebral Arteries Induced by Pre-Existing Hypertension Is Intact After Traumatic Brain Injury. N. Szarka, K. Amrein, E. Czeiter, A. Buki, A. Koller, P.J. Toth. University of Pecs, Hungary and University of Physical Education, Hungary. E224 684.4 Arteriolar Vasodilation Involves Actin Depolymerization. P.S. Clifford, B.S. Ferguson, J.L. Jasperse, M.A. Hill. University of Illinois Chicago, University of Missouri and Pepperdine University. E225 684.5 Influence of Ischaemia-Reperfusion Injury on Sensory Nerve Control of Vasodilation During a Subsequent Bout of Local Skin Heating in the Forearm. G.W. McGarr, G.J. Hodges, S.S. Cheung. Brock University, Canada. E226 684.6 Angiotensin II-Mediated Vasoconstriction of the Visceral Adipose Tissue Vasculature Is Linked to Systemic Hypertension in Obesity. s. Park, S. Karki, S.M. Saggese, M.A. Zuriaga, B. Carmine, D. Hess, C. Apovian, N. Gokce. Boston University School of Medicine. E227 684.7 Phenotypic and Sex Differences in Microvesicles Released from Cultured Human Brain Microvascular Endothelial Cells in Response to Proinflammatory and Prothrombotic Stimuli. L.W. Hunter, M. Jayachandran, V.M. Miller. Mayo Clinic. E228 684.8 Characterization of TRPV1 and TRPV2 Channel Expression and Vasomotor Function in Human Arterioles. A.M. Korishettar, Y. Nishijima, S. Cao, D. Zhang. Medical College of Wisconsin.

E229 684.9 Loss of Nitric Oxide Contributes to Perturbations in Myocardial Oxygen Balance in Exercising Swine with Multiple Comorbidities. J. van de Wouw, O. Sorop, R.W. van Drie, D. Merkus, D.J. Duncker. E230 684.10 Polyethylene Glycol Camouflaged Earthworm Hemoglobin. P. Cabrales, V. Jani. Bioengineering—UCSD. E231 684.11 Effect of Acute Increases in Retrograde Shear on Near-Infrared Spectroscopy Derived Microvascular Reactivity. M. Ramos, C.D. Black, P.A. Branch, J.T. Caldwell, G.C. Wardlow, C.J. Ade. University of Oklahoma and Kansas State University. E232 684.12 Influence of Ischaemia-Reperfusion Injury on the Subsequent Response to Local Heating in Non-Glabrous and Glabrous Skin of the Index Finger. G.W. McGarr, G.J. Hodges, S.S. Cheung. Brock University, Canada. E233 684.13 Effect of Noradrenergic Blockade on LowFrequency Oscillations of Human Skin Microcirculation. A.T. Del Pozzi, M.M. Mallette, Z.T. Martin, G.J. Hodges. Ball State University and Brock University, Canada. E234 684.14 Human Skeletal Muscle Feed Artery Function: Role of the Advanced Glycation End-Products Receptor (RAGE). S. Park, O. Kwon, R.H. Andtbacka, J.R. Hyngstrom, R.S. Richardson. University of Utah, George E. Whalen VA Medical Center, Huntsman Cancer Hospital and University of Utah. E235 684.15 Direct Implications for Caveolin-1 in TRPV1 Mediated NO Production: Elucidating a Mechanism of Vasoreactivity. J.N. Fahmy, S. Andrei, D.J. DelloStritto, W. Geldenhuys, D.S. Damron, I.N. Bratz. Northeast Ohio Medical University, Kent State University and West Virginia University. E236 684.16 Contribution of Adiponectin to Vascular Responses in Bone Resistance Arteries in Mice. P. Ghosh, K. Hotta, T. Lucero, K. Borodunovich, M. Cowan, J. Bramy, B. Behnke, M. Delp, J. Delp. Florida State University and Kansas State University. E237 684.17 Contribution of kV7 Channels to AcetylcholineInduced Dilation in Human Adipose Arterioles. Y. Nishijima, D. Zhang. Medical College of Wisconsin. E238 684.18 Pharmacological or Genetic Interruption of Focal Adhesion Kinase Improves Endothelial Barrier Dysfunction Resulting from Ischemia/Reperfusion Injury. R.J. Haines, S. Zhang, R.A. Eitnier, F. Wang, C.G. Yang, M.H. Wu. University of South Florida and Morsani College of Medicine. E239 684.19 The Role of Formyl Peptide Receptors (FPRs) in Cerebral Microvascular Dysfunction in Sickle Cell Disease. F.N. Gavins, J. Ansari, E.Y. Senchenkova, S.A. Vital. LSU Health Sciences Center. E240 684.20 A Mathematical Model of Cerebral Blood Flow Control: Role of Kir Channels. A. Moshkforoush, T. Longden, F. Dabertrand, M. Nelson, N. Tsoukias. Florida International University and University of Vermont. E241 684.21 Prolonged Sitting Results in Microvascular, but Not Macrovascular, Dysfunction in Healthy Young Women. J.R. Vranish, B.E. Young, J. Kaur, J.C. Patik, J. Padilla, P.J. Fadel. University of Texas at Arlington and University of Missouri.

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685. INSTRUMENTATION, METHODOLOGY, AND EXPERIMENTAL MODELS Poster (Sponsored by: The Microcirculatory Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E242 685.1 Assessment of Cutaneous Microcirculation Autoregulation with Phase and Linear Based Eulerian Video Magnification. M. Golden, J. Smith, D. Oswald, C. Haselby, R. Murphy, K.P. Heinking, K.K. Henderson. Midwestern University. E243 685.2 An Ischemia Model on a Chip. W. Yin, L. Abejar, D.A. Rubenstein, M.D. Frame. Stony Brook University. E244 685.3 CRISPR/Cas9 Creation of a Mouse Lacking a Unique Motif on Alpha Globin Demonstrates Its Critical Role in Regulating Nitric Oxide in Vivo. G.B. Broseghini Filho, J.T. Butcher, S.T. Keller, S. Poonam, H. Kwangseok, L.J. DeLalio, X. Wenhao, A.S. Padilha, L. Columbus, S. Sonkusare, B.E. Isakson. Federal University of Espirito Santo, Brazil and University of Virginia. E245 685.4 Adipose Tissue–Skeletal Muscle Crosstalk: Obese Human Subcutaneous and Visceral Adipose Tissues Both Supress Muscle Insulin Signalling in Men and Women. O. Sarr, R.J. Strohm, T.L. MacDonald, J.K. Reed, J. FouteNelong, D.J. Dyck, D.M. Mutch. University of Guelph, Canada and Guelph General Hospital, Canada. E246 685.5 Novel Approaches to Manipulate Gene Expression in the Mouse Kidney: siRNA Silencing and Gene Rescue. L.D. Asico, P. Konkalmatt, V.M. Villar, X. Wang, I. Armando, H. Lin, P.A. Jose. The George Washington University School of Medicine and Health Sciences. E247 685.6 Maintenance of Nerves in the Rat Mesentery Culture Model. N. Hodges. Tulane University. E248 685.7 Partitioning Resistance to Plasma Fluid Within Endothelial Glycocalyx. F.E. Curry. University of California, Davis.

686. CARDIAC ELECTROPHYSIOLOGY

687. HEART FAILURE Poster (Sponsored by: APS Cardiovascular Section)

Poster

Sun. 9:00 am—McCormick Place Convention Center, Hall F

(Sponsored by: APS Cardiovascular Section)

Presentation time: 12:45 pm–3:00 pm

Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E249 686.1 Glucocorticoids Modulate Kvβ1 Dependent Cardiac Function Through Potassium Channel (Kv) Activity. J. Tur, S.L. Badole, K.C. Chapalamadagu, S.M. Tipparaju. University of South Florida. E250 686.2 Heart-Rate Corrected QT Interval Prolongation in Impaired Fasting Glucose and Type 2 Diabetes: The Polish Norwegian Study (PONS). G. Vaidean, S. Vansal, M. Manczuk, J. Williams.

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E251 686.3 LITAF, a Novel Regulator of Cardiac Excitation. K.S. Moshal, K. Roder, A.A. Werdich, N.T. Dural, T. Kim, L.L. Cooper, Y. Lu, B. Choi, D. Terentyev, C. MacRae, G. Koren. Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brigham and Womens Hospital and Gazi University, Turkey. E252 686.4 Effects of Ryanodine on Electrical Activity of Cells with Slowest dV/dtmax in Newborn and Adult Mice Sinoatrial Node. M. Gonotkov, V. Golovko. Institute of Physiology, Komi Science Center, The Urals Branch of the Russian Academy of Sciences and Russian Federation. E253 686.5 Sex Differences in Hypertension Development Strategy: A Role of LF HRV Power. V.E. Shekh. V. N. Karazin Kharkiv National University, Ukraine. E254 686.6 Exercise Training Fails to Protect Against Development of Ischemia-Induced Ventricular Fibrillation in Isolated Rat Hearts. H. Clements-Jewery, P. Radich, N. Rawson, A.S. Hatcher. University of Illinois College of Medicine at Rockford and West Virginia School of Osteopathic Medicine. E255 686.7 The Contribution Na-Current in Generating of Upstroke Action Potential in the Cells of Sinoauricular Region of Mouse, Guinea Pig, Rabbit and Pig. E. Lebedeva, V. Golovko. Institute of Physiology, Komi Science Centre and the Ural’s Branch of the Russian Academy of Sciences, Russian Federation. E256 686.8 Second Hand Smoke Exposure Increases Susceptibility to Arrhythmogenic Cardiac Alternans. Z. Wang, L. Wang, K.E. Pinkerton, C. Chen, C.M. Ripplinger. University of California, Davis. E257 686.9 Functional Microdomain in the Cardiac Pacemaking in Mouse. D. Lang, A. Warden, T. Kamp, A. Glukhov. University of Wisconsin-Madison. E258 686.10 Extracting Noise from Electrocardiograms in Real-Time to Predict the Onset of Cardiac Arrest. J.M. Aboulhosn, S. Sindi, R.M. Ortiz. University of California at Merced.

E259 687.1 N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats with Persistent Pressure Overload. D.R. Abreu Reyes, C.R. Moreno, M.J. Gomes, L.U. Pagan, R.L. Damatto, F.C. Damatto, I.C. Depra, A.A H. Fernandes, K. Okoshi, M.P. Okoshi. Botucatu Medical School, Sao Paulo State Universit, Brazil, Botucatu Medical School, Sao Paulo State University, UNESP, Brazil, Botucatu Medical School, Sao Paulo State University and UNESP, Brazil. E260 687.2 Changes in Plasma β-Adrenergic Receptor Kinase-1 Following Left Ventricular Assist Device Placement. Q. Denfeld, C.S. Lee, W.R. Woodward, B.A. Habecker. Oregon Health & Science University Knight Cardiovascular Institute and Oregon Health & Science University.

SUNDAY PHYSIOLOGY E261 687.3 Alterations in the Balance of Cardiomyocyte Glucocorticoid and Mineralocorticoid Receptor Signaling Lead to Heart Failure. R. Oakley, D. Cruz-Topete, B. He, J. Foley, P. Myers, E. Murphy, P. Chambon, M. Willis, J. Cidlowski. NIEHS/NIH, NHLBI/NIH, IGBMC, France and McAllister Heart Institute. E262 687.4 Glucocorticoid Receptor Signaling Is Critical for microRNA Gender-Specific Regulation of Gene Expression in the Adult Mouse Heart. D. Cruz-Topete, R.H. Oakley, X. Xu, J.A. Cidlowski. NIEHS/NIH and LSU Health Science Center-Shreveport. E263 687.5 The Sphingosine-1-Phosphate Analog, FTY720, Reverses Diastolic Dysfunction and Hypertrophy in Familial Hypertrophic Cardiomyopathy. D.M. Ryba, C.M. Warren, C.N. Karam, R.T. Davis; 3rd, S.A. Chowdhury, M.G. Alvarez, D.F. Wieczorek, R. Solaro, B.M. Wolska. University of Illinois at Chicago, University of Cincinnati and University of Illinois at Chicago. E264 687.6 Impact of HFpEF on the Development of Neuromuscular Fatigue During Exercise. J.C. Weavil, T.S. Thurston, T.J. Hureau, J.R. Gifford, A.D. Bledsoe, J.N. Nativi, R.S. Richardson, M. Amann. University of Utah. E265 687.7 Intracoronary Gene Therapy with AdvCRTC2 Improves LV Dysfunction After Pressure Load Hypertrophy. M.L. Tay, N.C. Lai, D. Giamouridis, E. Tang, T. Tang, W. Lew. VMRF and University of Chicago. E266 687.8 Would Healing Was Improved in Mice After Myocardial Infarction by Nature Naphthoquinone Shikonin. A. Cai, D. Bedja, Z. Cai. CL Laboratory and LLC. E267 687.9 α1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle. P.M. Cowley, G. Wang, P.M. Swigart, D.H. Lovett, P.C. Simpson, A.J. Baker. University of California, San Francisco, VA Medical Center SF. E268 687.10 Heterozygous Deletion of Mediator Subunit 1 Causes Heart Failure in Mice. K. Spitler, C. Grueter. University of Iowa. E269 687.11 Aortic-Banding and Ovariectomy Independently Promote Coronary Artery Stiffness and Structural Remodeling. A. Ouyang, J. Hiemstra, T. Olver, J.C. Edwards, J.R. Ivey, P.K. Thorne, C.A. Emter, B.S. Fleenor. University of Kentucky and University of Missouri-Columbia. E270 687.12 Exercise Training Augments Neuronal Nitric Oxide Synthase Dimerization in the Paraventricular Nucleus of Rats with Heart Failure. N. Sharma, X. Liu, T. Llewellyn, K.P. Patel. University of Nebraska Medical Center. E271 687.13 Urocortin-3 Gene Transfer Increases Function of the Failing Heart in Mice. D. Giamouridis, N.C. Lai, M. Gao, M. Blankesteijn, E. Biessen, H.K. Hammond. Maastricht University, Netherlands, Veterans Medical Research Foundation and UC San Diego. E272 687.14 Ipragliflozin Prevents the Worsening of Ischemic Heart Failure in Diabetic Rats Independent of Its Diuretic Effect. K. Kamada, K. Saku, T. Kishi, T. Akashi, T. Takehara, H. Tsutsui, K. Sunagawa. E273 687.15 Multiple Co-Morbidities Have Detrimental Effects on Myocardial Function and Perfusion in a Large Animal Model of Diastolic Dysfunction. O. Sorop, J. van de Wouw, R.W. van Drie, I. Heinonen, V.J. de Beer, A.H. van den Meiracker, J. van der Velden, J.A. Joles, D. Merkus, D.J. Duncker. Erasmus MC, Netherlands, University of Turku, Finland, VU University Medical Center, Netherlands and UMC Utrecht, Netherlands.

E274 687.16 How Does the Overexpression of DGKζ Can Improve the Survival and Rescue the Heart Failure Associated Loss of Contractility? N. Aslam. BioSystOmics. E275 687.17 Reinstallation of Glucocorticoid Receptor (GR) in the Heart Rescues Left Ventricular Systolic Function of Cardiac GR Knockout Mice. B. He, R.H. Oakley, P.H. Myers, J.A. Cidlowski. NIEHS/NIH. E276 687.18 Evidence of an Exaggerated Muscle Metaboreflex Response in Heart Failure with Preserved Ejection Fraction. H.L. Clifton, S.M. Ratchford, J.R. Vranish, J.D. Trinity, J.J. Ryan, R.S. Richardson, P.J. Fadel, S. Sarma, M. Haykowsky, W. Wray. Salt Lake City Veterans Affairs Medical Center, University of Utah, University of Texas at Arlington, University of Texas Southwestern Medical Center and Texas Health Presbyterian Hospital. E277 687.19 Diaphragm Muscle Function and Antioxidant Levels in Chronic Heart Failure. B.T. Hackfort, R. Lewis, L. Gao, I.H. Zucker, H.D. Schultz. University of Nebraska Medical Center. E278 687.20 Increased Circadian Variations in Chemoreflex Sensitivity in Chronic Heart Failure. R. Lewis, B.T. Hackfort, H. Schultz. University of Nebraska Medical Center. E279 687.21 Identification of HuR-Dependent Gene Expression in Cardiac Hypertrophy. S. Slone, S.R. Anthony, M.L. Nieman, J.N. Lorenz, J. Rubinstein, J.B. Benoit, M. Tranter. University of Cincinnati. E280 687.22 The Superposition of Work on a Pathologic Microenvironmental Stiffness May Regulate Actin Assembly via Phosphorylation and Sarcomeric Redistribution of PKCε. M. Mkrtschjan, A. Wondmegegn, A. Arena, J. Li, B. Russell. University of Illinois at Chicago.

688. PHYSIOLOGY OF CARDIAC MUSCLE

S U N

Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E281 688.1 The EffectS of Quarky Ca2+ Release on Ca2+ Spark in Cardiac Myocytes. X. Chen, Y. Huo, W. Tan. College of Engineering, Peking University, People’s Republic of China, Shenzhen Graduate School, Peking University, People’s Republic of China. E282 688.2 Rewarming Shock Decreases Mitochondrial Respiratory Function in Cardiomyocytes. A. Cody, A. Eshaq, N. Schaible, Y.S. Han, T. Tveita, G. Sieck. Mayo Clinic and Artic University of Norway, Norway. E283 688.3 The Uremic Metabolite, Trimethylamine-NOxide (TMAO), Directly Alters Cardiac Contractile Function. C. Oakley, M. Hendrix, M. Grillo, D. McCarthy, J.R. Stubbs, M.J. Wacker. School of Medicine, University of Missouri-Kansas City, Kidney Institute and University of Kansas Medical Center. E284 688.4 Does β-Adrenergic/PKA Signaling Modulate Ca2+-Sensitivity and Force Kinetics in Myofibrils from Mice Carrying the FHC Related Mutation CTnI-ΔK184? G. Pfitzer, F. Elhamine, A.M. Wies, S. Zittrich, S. Papadopoulos, M.M. Schroeter, R. Stehle, D. Möhner. University of Cologne, Germany.

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PHYSIOLOGY SUNDAY E285 688.5 Differential Effects of Isoproterenol and Omecamtiv Mecarbil on the Contractile Properties of Unloaded Myocytes. J.D. Isaac, T.D. Buckley, K.S. Campbell. University of Kentucky. E286 688.6 Single Cardiac Myocytes from the Left and Right Ventricles Respond Similarly to Isoproterenol and Omecamtiv Mecarbil. T.D. Buckley, J. Isaac, K.S. Campbell. University of Kentucky. E287 688.7 Cardiac Hypertrophy and Myocyte Remodeling Are Exacerbated with Multiple Pregnancies. M. Wagner, A. Nelson, C. Flake, D. Eaton, B.A. Bailey. Ursinus College and Lewis Katz School of Medicine at Temple University. E288 688.8 Endurance Exercise Is Associated with Decreased Calpain to Calpastatin Ratios in Aged Rat Hearts. J.J. Sepe, T.A. Hacker, G.M. Diffee. University of Wisconsin-Madison. E289 688.9 Indices of Autophagy Are Unaltered by Quercetin Consumption in Hearts of Mdx/Utrn+/- Mice. J.C. Quindry, T.S. Quindry, C.G. Ballmann, J.T. Selsby. University of Montana, Samford University and Iowa State University. E290 688.10 Cardiovascular Protective Effects of AT2R Activation by Peptide Drug NP-6 A4. P. Beauparlant, A. Mahmood, R. Toedebusch, V. DeMarco, S. Ardhanari, S. Kumar, L. Pulakat. University of Missouri and Harry S. Truman VA Memorial Hospital. E291 688.11 Cardiac Myosin Binding Protein C Mutants Interact with Hsp70-Family Chaperones and Disrupt Protein Quality Control. A.A. Glazier, A. Helms, S. Kotlo, N. Hafeez, J. Yob, V. Tang, D. Mellacheruvu, A. Nesvizhskii, S. Day. University of Michigan and Johns Hopkins University.

689. ENDOTHELIAL CELL BIOLOGY I Poster (Sponsored by: APS Cardiovascular Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E292 689.1 Functional Screening of Mammalian Mechanosensitive Genes Using Drosophila RNAi Library— Smarcd3/Bap60 Is a Mechanosensitive Pro-Inflammatory Gene. S. Kumar, H. Jo. Emory University. E293 689.2 Ammonia Promotes Endothelial Cell Survival via the Heme Oxygenase-1-Mediated Release of Carbon Monoxide. W. Durante, X. Liu, K.J. Peyton. University of Missouri. E294 689.3 P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. M. Gabani, Q. Li, Y. Kim, A. Vikram, S. Kumar, M. Kassan, S. Kim, J. Jacobs, K. Irani. University of Iowa. E295 689.4 Cytosolic Active Caspase 3 Promotes Endothelial Barrier Integrity After Thrombin Stimulation. M. Damarla, L. Servinsky, K. Carino, K. Suresh, L. Johnston, L. Shimoda, P. Hassoun. JHU. E296 689.5 Effect of Uremia on Downregulation of TLR4 and Upregulation of Cytokines in Endothelial Cell. J.F. Rebello, R.B. Brito, W.R. Oliveira, G.F. Ribeiro, C.C. Grabulosa, A.S. Dias, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil.

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E297 689.6 Controlling Hydrogen Sulfide Concentrations via PDMS Microfluidics for Endothelial Cell Culture. T. Christoforidis, T. Driver, J. Rehman, D. Eddington. University of Illinois at Chicago. E298 689.7 Microparticle Uptake by Pulmonary Microvascular Endothelial Cells. A.K. Scruggs, T.C. Rich, N.N. Bauer. University of South Alabama. E299 689.8 Endothelium-Independent Vasorelaxation Induced by Nitric Oxide Generation from the Novel Organic Nitrate NDOP Is Partially Mediated by Inward-Rectifier Potassium Channels. R.B. de Paula, M.F. Montenegro, M.S. França-Silva, M.C. Brandão, T.F. Diniz, V.S. Lemos, P.F. Athayde-Filho, M. Magnani, J.O. Lundberg, M. Carlström, V.A. Braga. Federal University of Paraíba, Brazil, Karolinska Institutet, Sweden and Federal University of Minas Gerais, Brazil. E300 689.9 Phosphorylation and Redistribution of Vangl2, a Planar Cell Polarity Protein, in Endothelial Cells in Response to Laminar Shear Stress. L. Curtis-Whitchurch, H. Rekapally, J. Hoying. University of Louisville. E301 689.10 Connexin 40 Plays a Crucial Role in the Myocardial Ischemia Reperfusion Injury of Type 2 Diabetic Mice. R. Si, R. Guo, A.H. Truong, A. Makino. University of Arizona. E302 689.11 Acid Sensing Ion Channel 1 Contributes to Ca2+ Influx in Endothelial Tubes from Small Mesenteric Resistance Arteries. S.M. Garcia, L.M. Herbert, J.S. Naik, T.C. Resta, N.L. Jernigan. University of New Mexico Health Sciences Center. E303 689.12 Endothelial Specific Epithelial Sodium Channel Activation Prompts Vascular Stiffness in Female Mice. G. Jia, A.R. Aroor, B.J. Barron, C. Manrique, G. Lastra, A. WhaleyConnell, G.A. Meininger, F. Jaisser, J.R. Sowers. University of Missouri School of Medicine, UPMC University Paris 06 and Université Paris Descartes, France. E304 689.13 Sphingosine Kinase 1 and S1P Transporter Spns2 Plays Important Role in HGF Mediated Lamellipodia Formation in Lung Endothelium. P. Fu, D.L. Ebenezer, E.V. Berdyshev, M. Shaaya, A. Harijith, V. Natarajan. University of Illinois at Chicago and National Jewish Health. E305 689.14 Shear Stress Induces Apoptosis via Cytochrome C Release from Dynamic Mitochondria in Endothelial Cells. Y. Hu, S.S. Hur, L. Lei, Y. Wang, S. Chien. Institute of Engineering in Medicine, University of California at San Diego. E306 689.15 APJ Inhibition Reduces Flow-Induced Endothelial Cell Migration with Atorvastatin but Not Pravastatin Treatment. I. Materzok, F. Lorenz, M. Bahls, A. Strohbach, M. Dörr, S.B. Felix, R. Busch. University Medicine Greifswald, Germany. E307 689.16 Endothelial Cell Mechanical Responses Are Dependent on Both Fluid Shear Stress and Tensile Strain. E. Steadman, D. Meza, D.A. Rubenstein, W. Yin. Stony Brook University. E308 689.17 Microparticle Delivery of Cyclic AMP to Pulmonary Microvascular Endothelial Cells. A.K. Scruggs, S.J. Leavesley, N.S. Annamdevula, T.C. Rich, N.N. Bauer. University of South Alabama. E309 689.18 Aerobic Fitness Does Not Improve Endothelial Function and Responses to Acute Exercise in Perimenopausal Women. C. Serviente, S. Witkowski. University of Massachusetts Amherst.

SUNDAY PHYSIOLOGY E310 689.19 5-Methoxytryptophan Promotes Endothelial Cell Regeneration After Vascular Injury. Y. Ho, C. Chen, M. Wu, H. Ho, L. Liang, S. Yet. National Health Research Institutes, Taiwan.

E311 690.1 Use of Phase Loop Plots to Assess Ca2+ Sensitivity of Force Generation in Airway Smooth Muscle. Y.S. Han, G. Sieck. Mayo Clinic. E312 690.2 The Novel and Selective KV7 Channel Activator, ML213, Reveals Key Physiological Roles for KV7.4 and KV7.5 Channel Subtypes in Guinea Pig Detrusor Smooth Muscle Function. A. Provence, D. Angoli, G. Petkov. University of South Carolina. E313 690.3 TNFα Induces Mitochondrial Fragmentation and Mitochondrial Biogenesis in Human Airway Smooth Muscle Cells. E.S. Kaul, P. Delmotte, G.C. Sieck. McGill University, Canada and Mayo Clinic. E314 690.4 Differential Effects of Cannabinoid Receptor Stimulation in Smooth Muscle. A.M. Bermudez, J.M. Visina, L.A. Walker. University of Colorado, University of Portland and University of Alabama. E315 690.5 Effect of Pregnancy on Aortic and Carotid Vascular Function. M. Zynda, K.A. Klatt, J. Vallejo-Elias, K.E. Cooper, D.M. Eckman. Midwestern University. E316 690.6 In Mice, KCNQ Channel Modulators Affect Afferent Nerve Activity and Not Urinary Bladder Smooth Muscle Contractility Directly. N.R. Tykocki, T.J. Heppner, A.D. Bonev, M.T. Nelson. University of Vermont. E317 690.7 Calcium Influx Through CaV1 and TRP Channels Induced by the Calcium Release via RyR Activates BKCa in Mouse Mesenteric Artery. D.C. Garcia, M.J. Lopes, V.S. Lemos, S.F. Cortes. Federal University of Minas Gerais, Brazil.

E320 691.3 Sex Differences in Obesity-Associated Vascular/Perivascular Remodeling and Adipokine Production in Obese Patients Undergoing Roux-en-Y Bariatric Surgery. R.K. Mui, R.N. Fernandes, J.J. Galligan, G.D. Fink, C.N. Pereira-Hicks, R.E. Watson, M.K. Lane, H. Xu. Michigan State University. E321 691.4 High Fat Diet Induces Hypertension but Not Vascular and Cardiac Remodeling in Female Dahl Sensitive Rats. R. Fernandes, P.A. Perez Bonilla, H. Garver, J.J. Galligan, G.D. Fink, H. Xu. Michigan State University. E322 691.5 Microvascular Endothelial Function in Lean Versus Obese Women with Polycystic Ovary Syndrome: Role of the Endothelin B Receptor. C.W. Usselman, H.S. Taylor, N.S. Stachenfeld. John B. Pierce Laboratory and Yale University. E323 691.6 Sex Differences in Mesenteric Arterial Function at Pre-Diabetic and Diabetic Stage of UC Davis Type 2 Diabetic Mellitus Rats. S. Shaligram, F. Akther, J.L. Graham, K.L. Stanhope, P.J. Havel, R. Rahimian. University of the Pacific, University of California at Davis. E324 691.7 Sex Difference in the Patho-Physiological Consequences of Adipocyte PRR Deficiency. E. Gatineau, D. Cohn, Y. Liu, M. Gong, F. Yiannikouris. University of Kentucky. E325 691.8 Relationship Between Body Mass Index and Endothelial Dysfunction in Women with and Without Polycystic Ovary Syndrome. T.E. Adler, C.W. Usselman, L.C. Anaeto, R.G. Schapiro, F.E. Steele, N. Toffoloni, A. Takamata, H.S. Taylor, N.S. Stachenfeld. John B. Pierce Laboratory, Nara Women’s University, Japan and Yale University. E326 691.9 Obesity Amplifies the Sympathoexcitatory Response to Insulin in Male, but Not Female, Rats: Role of Neuropeptide Y Inputs Into the Paraventricular Nucleus. Z. Shi, P.A. Cassaglia, V.L. Brooks. Oregon Health & Science University. E327 691.10 Sex Differences in Mechanisms of Resistance Vessel Endothelial Dysfunction Due to Cardiometabolic Risk Factors and the Role of Endothelial Mineralocorticoid Receptors. A.P. Davel, E. Moss, I. Anwar, Q. Lu, I.Z. Jaffe. Tufts Medical Center and University of Campinas, Brazil. E328 691.11 Bardet-Biedl Syndrome 1 (BBS1) Protein Contributes to Vascular Endothelial Function. J. Jiang, J.J. Reho, K. Rahmouni. University of Iowa.

691. SEX DIFFERENCES IN OBESITY AND CARDIOVASCULAR DISEASE

692. GENETIC FACTORS AND MECHANISMS OF PREECLAMPSIA I

690. PHYSIOLOGY OF SMOOTH MUSCLE Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm

Poster

Poster

(Sponsored by: APS Cardiovascular Section)

(Sponsored by: APS Physiological Genomics Group)

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:45 pm–3:00 pm

Presentation time: 12:45 pm–3:00 pm

E318 691.1 Suppression of Aldosterone Production Via High Salt Diet and Deficiency in Endothelial Mineralocorticoid Receptors Prevents Leptin-Mediated Endothelial Dysfunction Exclusively in Female Mice. J.L. Faulkner, T. BruderNascimento, I. Jaffe, E. Belin de Chantemele. Augusta University and Tufts University. E319 691.2 BK Channel β1-Subunit Deficiency Protects Against High Fat Diet-Induced Metabolic Disorders in the Absence of Hypertension and Exacerbated Vascular Fibrosis/ Remodeling in Female Mice. H. Xu, R. Fernandes, H. Garver, J.J. Galligan, G.D. Fink. Michigan State University.

E329 692.1 Increases in Cytochrome P450 Expression and 20-HETE Production Reduce Mean Arterial Pressure in an Animal Model of Preeclampsia. J. Cotton, W. Wu, S. Murphy. University of Mississippi Medical Center. E330 692.2 Determining the Role of Maternal Leptin and Activity in Pregnancy Outcomes. T.E. Nishimura, P.M. Polgreen, L.A. Polgreen, D.S. Brandt, K.M. Thomas, S.M. Scroggins, N.J. Evans, L.B. Alexander, M.K. Santillan, D.A. Santillan. University of Iowa Hospitals & Clinics, University of Iowa College of Pharmacy and University of Iowa Graduate College.

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PHYSIOLOGY SUNDAY E331 692.3 Reduced Placental Regulator of G-Protein Signaling-2 (RGS2) and Preeclampsia. K.J. Perschbacher, J.A. Sandgren, L. Carrillo-Saenz, P.C. Witcher, N.A. Pearson, D.A. Santillan, E.J. Devor, G.L. Pierce, M.K. Santillan, R.A. Fisher, K.N. Gibson-Corley, J.L. Grobe. University of Iowa. E332 692.4 Reduced Uterine Perfusion Pressure-Induced Preeclampsia Acquires Salt-Sensitivity Characteristics in Postpartum. T. Matsuura, K. Shinohara, T. Kishi, H. Tsutsui, Y. Hirooka. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Japan, Collaborative Research Institute of Innovative Therapeutics for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Japan, Department of Advanced Cardiovascular Regulation and Therapeutics, Center for Disruptive Cardiovascular Medicine and Kyushu University, Japan. E333 692.5 Pre-Conception Leptin Resistance Characterizes the BPH/5 Mouse Model of Preeclampsia. E.F. Sutton, H.E. Lob, C. Liu, L.M. Redman, R.L. Davisson, J.L. Sones. Louisiana State University, Cornell University, Louisiana State University School of Veterinary Medicine and Weill Cornell Medical College. E334 692.6 Altered Water Homeostasis in a Novel NonHuman Primate Model of Gestational Hypertension. C.C. Weaver, M.K. Rhoads, J.L. Grobe, J.L. Osborn. University of Kentucky, University of Iowa Carver College of Medicine and Biomedical Science Research Group. E335 692.7 Preeclampsia Alters Androgen MetaboliteInduced Vasorelaxation of Rat Uterine Artery. A.E. Hanson, J.N. Stallone. Texas A&M University. E336 692.8 Expression of MEF2 Transcription Factors in Human Placenta and Involvement in Trophoblast Invasion and Differentiation. L. Li, X. Gong, L.P. Rubin. Texas Tech University Health Sciences Center.

693. NEUROINFLAMMATION/NEUROPROTECTION/ ISCHEMIA

E341 693.5 In Vitro Analysis of Catalase-, Oxidase- and SOD-Mimetic Activity of Commercially Available and CustomSynthesized Cerium Oxide Nanoparticles and Assessment of Neuroprotective Effects in a Hippocampal Brain Slice Model of Ischemia. A.Y. Estevez, B. Stadler, J.S. Erlichman. St. Lawrence University and CerionNRx. E342 693.6 Neural Stem Cells Reduce Symptomatic Inflammation and Mortality in Aged Stroke Mice Following Delayed tPA Treatment. A.D. Eckert, M. Hamblin, J. Lee. Tulane University Health Science Center. E343 693.7 Macrophage Heterogeneity and Stem Cell Derived Tyrosine Kinase (STK) Regulate Chronic CNS Inflammation in Diet Induced Obesity (DIO). A. Dey, J.N. Allen, J.W. Fraser, R.F. Paulson, P. Hankey-Giblin. Penn State University. E344 693.8 Chronic Ketosis Modulates Metabolite Profiles and Cell-Signaling Pathways in Mouse Brain. J. LaManna, K. Sharma, D. Ye, J.M. Berthiaume, Y. Luo, K. Xu, M.A. Puchowicz. Case Western Reserve University. E345 693.9 Behavioral and Inflammatory Response in Animals Exposed to a Low-Pressure Blast Wave and Supplemented with β-Alanine. J.R. Hoffman, A. Zuckerman, O. Ram, O. Sadot, J.R. Stout, I. Ostfeld, H. Cohen. University of Central Florida, Ben-Gurion University, Israel, Ben Gurion University, Israel and Israel Defense Forces, Israel. E346 693.10 Mitochondrial Transplantation Restores Bioenergetics After Spinal Cord Injury. J. Gollihue, S. Patel, K. Eldahan, D. Cox, A. Rabchevsky. University of Kentucky. E347 693.11 NMDA Receptor-Mediated Synaptic Transmission in the Spinal Dorsal Horn and Spinal Nerve Ligation-Induced Nociceptive Behavior Are Enhanced in Serine Racemase Knockout Mice. T. Fukushima, E. Kato, R. Konno, Y. Hori. Dokkyo Medical University, Japan.

694. CELLULAR MECHANISMS OF STRESS AND INFLAMMATION Poster

Poster (Sponsored by: APS Central Nervous System Section)

(Sponsored by: APS Cell and Molecular Physiology Section)

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:45 pm–3:00 pm

Presentation time: 12:45 pm–3:00 pm

E337 693.1 Identification of a Molecular Mechanism Underlying Estrogen-Mediated Neuroprotection in Neuronal Cells Against Oxidative Stress. S. Park, J. Won, Y. Hong. College of Biomedical Science & Engineering, Inje University, Republic of Korea, Graduate School of Inje University, Republic of Korea, Inje University, Republic of Korea. E338 693.2 Dihydrotestosterone Mediates Neuroprotective Effects via Estrogen Receptor Beta Following Brain IschemiaReperfusion Injury in Male Mice. S. Shi, Q. Liu, R.J. Gonzales. University of Arizona and Barrow Neurological Institute. E339 693.3 Neuroprotective Effect of Low Dose Alcohol Consumption Against Transient Focal Cerebral Ischemia. K.D. McCarter, H. Sun, C. Li. LSU Health Sciences Center -Shreveport. E340 693.4 Reciprocal Control of Apoptotic Cell Death and Synaptic Plasticity by DAPK1 Depletion in Focal Cerebral Ischemic Brain. J. Won, S. Park, Y. Hong. Inje University, Republic of Korea.

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E348 694.1 The Protective Role of NHERF1 in CisplatinInduced Acute Kidney Injury. A.M. Bushau-Sprinkle, A.R. Sherwood, C.A. Conklin, M.T. Barati, T. Dupre, L. Siskind, K.B. Gagnon, S.J. Khundmiri, E.D. Lederer. University of Louisville, Howard University and Robley Rex Veteran Affairs Medical Center. E349 694.2 Inhibition of PDE7 Reduces Inflammatory Response Following Renal Ischemia/Reperfusion Injury. W.R. Reis, M.A. Sun, T.A. Kronk, M.A. Blount. Emory University School of Medicine. E350 694.3 The Glycolysis Regulatory Enzyme PFK-FB3 Enhances Endothelial Barrier Restoration in Acute Lung Injury. L. Wang, P. Chaturvedi, S. Krantz, J. Klomp, N.M. Pohl-Avila, A. Ray, P.T. Toth, P. Carmeliet, A. Karginov, A.B. Malik, J. Rehman. UIC and VIB Vesalius Research Center, Belgium. E351 694.4 Inactivation of the PLA2 Activity of Prdx6 Ameliorates Sepsis-Induced Acute Lung Injury. J. VazquezMedina, J. Tao, P. Patel, C. Dodia, E. Sorokina, S.I. Feinstein, S. Chatterjee, A.B. Fisher. University of Pennsylvania.

SUNDAY PHYSIOLOGY E352 694.5 Expression of a Pulmonary Fibrosis Associated Surfactant Protein C Mutant, SP-CI73T, in Alveolar Type 2 Cells Induces Lung Inflammation and Aberrant Parenchymal Remodeling. A. Venosa, Y. Tomer, S. Jamil, M. Beers. University of Pennsylvania. E353 694.6 Proteomic Analysis Identifies Matrix Metalloproteinase-9 and -12 Regulated Apoptosis Substrates in the Post-Myocardial Infarction Left Ventricle. R.P. Iyer, E.R. Flynn, Y. Ma, M.L. Lindsey. University of Mississippi Medical Center and G.V. (Sonny) Montgomery Veterans Affairs Medical Center. E354 694.7 Mitochondrial Transcription Factor A and Cardiac Stability. G.H. Kunkel, N. Theilen, N. Jeremic, G. Weber, S.C. Tyagi. University of Louisville School of Medicine. E355 694.8 Divergent Effects of DHA Treatment and AMPK Activation on Protein Synthesis Rate and Signaling in Palmitate-Treated Skeletal Muscle. B.D. Perry, J.A. Rahnert, Y. Xie, P. Zhang, D. Espinosa, S. Price. Emory University and VA Medical Centre. E356 694.9 Contribution of Membrane Repair Defects to Skeletal Muscle Inflammation. K.E. McElhanon, N. Young, J. Hampton, E.X. Beck, Z. Sahenk, R. Aggarewal, C.V. Oddis, W.N. Jarjour, N.E. Weisleder. The Ohio State University, Research Institute at Nationwide Children’s Hospital and University of Pittsburgh. E357 694.10 Interleukin-10 in Type 1 Diabetes-Induced Bone Loss in Mice. N.D. Rios-Arce, S. Mohr, B. Coughlin, D. Feenstra, B. Christian, L.R. McCabe, N. Parameswaran. Michigan State University.

695. CELLULAR RESPONSES TO INFLAMMATION Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E358 695.1 Unravelling the Identity of Active Serine Proteases in Inflammatory Bowel Diseases. N. Vergnolle, C. Deraison, B. Chrystelle, A. Edir, B. Gilmore, M. Quaranta, M. Sebert, L. Alric, D. Bonnet, N. Bunnett, A. Denadai Souza. Inserm U-1220, France, Queen’s University, Ireland, CHU Toulouse, France and Columbia University. E359 695.2 The Host Engulfment Pathway in Enteroids Is Linked to Intestinal Inflammation Following Bacterial Infection. S. Das, E. Lim, K. Suarez, P.B. Ernst, K.E. Barrett. University of California San Diego. E360 695.3 Bacteria-Neutrophil Crosstalk: Genomic Approaches Identify G Protein-Coupled Receptors as New, Potential Targets for the Treatment of Infections. R. Corriden, K. Sriram, P.A. Insel. University of California at San Diego. E361 695.4 25(OH)D3 Treatment Improves Inflammatory Pathway on Monocytes Lineage (U937) in Uremic Environment. R.B. de Oliveira Brito, J.F. Rebello, W.R. ‘dos Santos Oliveira, C.C. Grabulosa, Y.S. Matos, C.S. Malta, H. Dellê, M.A. Dalboni. Universidade Nove de Julho, Brazil. E362 695.5 Interferon Type II Increases Lipolysis and Fatty Acid Oxidation in Pancreatic β Cells. N. Truong, J. Bazil, L. Olson. Michigan State University.

E363 695.6 Acute High Fat Diet Exposure Results in Discrete Shifts in the Adipose Tissue Inflammation Profile in Mice. B. Hetrick, A. Huffard, C. McCurdy. University of Oregon.

696. OXIDATIVE STRESS, MITOCHONDRIAL METABOLISM AND REDOX CHANGES IN HEALTH AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E364 696.1 The Effects of Conjugated Linoleic Acid and Berberine Supplementation on Markers of Oxidative Stress in Broiler Chickens. V. Dartigue, H. Klandorf, E. Falkenstein, K. Barnes, K. Van Dyke. West Virginia University, and West Virginia University School of Medicine. E365 696.2 Reversal of Ciprofloxacin-Induced Testosterone Reduction by Probiotic Microbes in Mouse Testes. C. Xie, F. Gao. Hebei Normal University, People’s Republic of China. E366 696.3 Phenotypic Abnormalities in Microvascular Endothelial Cells Isolated from the Sugen/Hypoxia Rat. K. Suresh, L. Servinsky, J. Huetsch, L. Shimoda. Johns Hopkins University. E367 696.4 The Mitohormetic Response and an Evaluation of a Method for Inducing Oxidative Damage. Y. Zhang, F. Humes, A. Brasher, A. Kavazis, W. Hood. Auburn University. E368 696.5 The Mitochondrial Adenine Nucleotide Pool Contributes to the Matrix Ca2+ Buffering System. A.J. Davani, C.D. Navarro, J.S. Heisner, V.R. Pannala, R.K. Dash, D.F. Stowe, A.K. Camara. Medical College of Wisconsin, Research Service and Zablocki VA Medical Center. E369 696.6 Estradiol Receptor Agonists α and β Protect Against Brain Mitochondrial Dysfunction in a Model of Sleep Apnea. S. Laouafa, A. Bairam, J. Soliz, D. Roussel, V. Joseph. IUCPQ, Université Laval, Canada, CNRS, UMR 5023—LEHNA and Université Claude Bernard Lyon 1., France. E370 696.7 Mitochondrial-Targeted Peptide SBT-20 Improves Mitochondrial Bioenergetics in Duchenne Muscular Dystrophy in a Mitochondrial Creatine Kinase Dependent Manner. M.C. Hughes, S.V. Ramos, N. Polidovitch, P. Backx, C.G. Perry. York University, Canada. E371 696.8 Hydrogen Sulfide Attenuates HomocysteineInduced Mitochondrial Toxicity in MC3T3-E1 Pre-Osteoblastic Cells. Y. Zhai, J. Behera, S. Tyagi, N. Tyagi. School of Medicine and University of Louisville. E372 696.9 Mitochondrial Fragmentation Is a Novel Feature of Adherent-Invasive E. coli Evoked Pathophysiology in Enteric Epithelia. N. Mancini, A. Wang, J. Shearer, D. McKay. University of Calgary, Canada. E373 696.10 Muscle gp130 Receptor Regulation of Oxidative Metabolism During Cancer Cachexia. D. Fix, J. Hardee, S. Gao, B. VanderVeen, J.A. Carson. University of South Carolina.

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PHYSIOLOGY SUNDAY E374 696.11 Nicorandil Reduces Lipoperoxidation in Stimulated and Non-Stimulated Atrophied Muscle. A. Sanchez-Perez, P. Padilla-Maldonado, E. Sanchez-Duarte, C. Coretes-Rojo, A. Saavedra-Molina, M. Gomez-Barroso, R. Montoya-Perez. Universidad Michocana de San Nicolas de Hildalgo, Mexico, Universidad de Colima, Mexico. E375 696.12 Up-Regulation of Nox4 Expression in DUSP4/- Hearts Is a Critical Factor in Modulating Cardiovascular Function Under Oxidative Stress. J.P. Lamb, A. BarajasEspinoza, A. Basye, M. Angelos, C. Chen. The Ohio State University College of Medicine.

697. INFLAMMATION AND AUTONOMIC REGULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E376 697.1 Chronic Inflammation Deactivated the MAPK Pathway and Decreased the TRPV1 Protein Expression in the 50B11 Dorsal Root Ganglion Cell Line. H. Wang, G.J. Rozanski, I.H. Zucker. University of Nebraska Medical Center. E377 697.2 Local Innervation Modulates Lymph Node Cellularity. C. Chen, L. Ince, A. de Juan, S. Hergenhan, W. He, D. Druzd, K. Kraus, C. Scheiermann. LMU Munich, Germany. E378 697.3 Distinguishing the Central Pathways of the Inflammatory Reflex from Those of Fever. D. Martelli, D.G. Farmer, S.T. Yao, M.J. McKinley, R.M. McAllen. Florey Institute of Neuroscience and Mental Health, Australia and University of Bologna, Italy. E379 697.4 Renal Inflammatory Response Mediated by Chronic Pain and Related Stress. B.B. Duong, M.L. Carder, G.S. Crosby, V. Duric, V. Babich, F. Di Sole. Des Moines University and Mercy College of Health Sciences. E380 697.5 Renal Denervation Prevents Nicotine-Induced Hypertension and Reduces Renal IL-17a. S.C. Harwani, J. Ratcliff, M.Z. Cicha, M.W. Chapleau, F.M. Abboud. University of Iowa. E381 697.6 Acute Electrical Vagal Nerve Stimulation Exerts Powerful Anti-Inflammatory Effects Through Its Nicotinic Action in Rats with Pulmonary Arterial Hypertension. K. Yoshida, K. Saku, M. Tanaka, K. Abe, T. Kishi, H. Tsutsui, K. Sunagawa. Kyushu University Graduate School of Medical Sciences, Japan and Kyushu University, Japan. E382 697.7 Decrease in Inflammation (CRP) and Heart Rate Through Mirthful Laughter. G. Bains, L. Berk, E. Lohman, N. Daher, B. Miranda. Loma Linda University. E383 697.8 Disruption of Mitochondrial Redox and Metabolic States in Norepinephrine-Exposed T-Lymphocytes. A.J. Case, C.W. Collins, C.T. Roessner, J. Tian, M.C. Zimmerman. University of Nebraska Medical Center. E384 697.9 The Therapeutic Potential of Modified DeepOcean Water on 2,4-Dinitrochlorobenzene Induced Atopic Dermatitis in Balb/c Mice. C. Ho, C. Chien. National Taiwan Normal University, Taiwan.

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698. RENAL OXIDATIVE STRESS AND HYPOXIA Poster (Sponsored by: APS Renal Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E385 698.1 Chronic Electronic Cigarette Vapor Inhalation Induces Renal Injury and Functional Decline in Female Mice. C. Drummond, L.E. Crotty Alexander, J. Tian. University of Toledo, University of California San Diego and Veterans Affairs San Diego Health System. E386 698.2 Hypoxia/Re-Oxygenation Increases the Response of Afferent Arterioles to Angiotensin II—Investigation in Mouse Kidney Slices. T. Pahlitzsch, D. Braun, M. Ludwig, P.B. Persson, A. Patzak. Charité-Universitätsmedizin Berlin, Germany. E387 698.3 The Impaired Vasodilatation in Rat Renal Interlobar Arteries After Hypoxia/Re-Oxygenation Is Endothelium Independent. D. Braun, M. Ludwig, P.B. Persson, S. Dietze, A. Patzak. Charite-Universitätsmedizin Berlin, Germany. E388 698.4 Acute Kidney Injury Induces Oxidative Stress and Distant Organ Dysfunction Due to Glutathione Depletion. Y. Shang, Y.L. Siow, C.K. Isaak, K. O. St. Boniface Hospital Research Centre, Canada, University of Manitoba, Canada and Agriculture and Agri Food Canada, Canada. E389 698.5 Intra-Operative Urinary Hypoxia During Cardiac Surgery on Cardiopulmonary Bypass Predicts Later Development of Acute Kidney Injury. R.G. Evans, M.Z. Zhu, J.A. Smith, G.K. Harrop, A.G. Thrift, A.D. Cochrane. Monash University, Australia and Monash Health, Australia. E390 698.6 The Effects of Telmisartan on Ischemia/ Reperfusion Injury of Rat Kidney. P. Lee. Tzu Chi University of Science and Technology, Taiwan. E391 698.7 Tempol Prevents the Enhancement of Angiotensin II Contractions of Afferent Arterioles from Mouse with Reduced Renal Mass. L. Li, E. Lai, Z. Luo, K.K. Griendling, W.K. Taylor, A. Wellsten, W. Welch, C.S. Wilcox. Georgetown University, Zhejiang University, People’s Republic of China, and Emory University. E392 698.8 Intermittent Hypoxia Increases Blood Pressure in Rats with Chronic Kidney Disease but Does Not Increase Fibrosis, Inflammation or Loss of Endothelial Dilators. J.L. Riggs, C.E. Pace, W. Giermakowska, H.H. Ward, L.V. Gonzalez Bosc, N.L. Kanagy. University of New Mexico Health Sciences Center.

SUNDAY PHYSIOLOGY

699. CELLULAR RESPONSE TO HYPOXIA Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E393 699.1 Withdrawn. E394 699.2 Withdrawn. E395 699.3 Surviving Low Oxygen: Exploring the Role of AMP-Activated Kinase in Anoxia-Tolerance. A.V. Carter. University of Maryland: Baltimore County.

700. CELLULAR AND INTEGRATED RESPONSES TO HYPOXIA Poster

E403 700.8 Hypoxia Activates BK and Kv Channels in Rat Carotid Body Glomus Cells. D. Kim, J. Wang. Rosalind Franklin University. E404 700.9 Effects of Hypoxia on Hydrogen Sulfide Production and Degradation Gene Expression Pathways. L.G. Forgan, B.A. McNeill, E. DeLeon, Y. Gao, K. Olson. Deakin University, Australia and Indiana University. E405 700.10 Identification of Vesicular Monoamine Transporter 2 (vmat2)-Containing O2 Chemoreceptors in the Gills of Zebrafish. W. Pan, A.L. Scott, C.A. Nurse, M.G. Jonz. University of Ottawa, Canada and McMaster University, Canada. E406 700.11 HOIL-1L and PKCζ Are Required for Na,KATPase Stabilization at the Plasma Membrane During Hypoxia. N.D. Magnani, M.A. Queisser, L.A. Dada, L.C. Welch, P. Brazee, A. Misharin, S.G. Budinger, J.I. Sznajder. Northwestern University.

701. RENAL HEMODYNAMICS, GLOMERULAR FILTRATION AND RENAL VASCULATURE

(Sponsored by: APS Hypoxia Group)

Poster

Sun. 9:00 am—McCormick Place Convention Center, Hall F

(Sponsored by: APS Renal Section)

Presentation time: 12:45 pm–3:00 pm E396 700.1 Cardiovascular Adaptations to Moderate Anemia Maintain Cerebral Perfusion but Are Inadequate to Prevent Renal and Splanchnic Tissue Hypoxia. N. Mistry, M. Solish, L. Cahill, Y. Zhou, A.G. Hare, A. Doctor, A.H. Lazarus, J.G. Sled, C. Mazer, G.M. Hare. St. Michael’s Hospital, Canada, University of Toronto, Canada, The Hospital for Sick Children, Canada and Washington University in St. Louis. E397 700.2 EffectS of DIfferent Oxygen Concentrations on Human Differentiated Preadipocytes Lipogenic and Lipolytic Functions. B. Mahat, J. Mauger, P. Imbeault. University of Ottawa, Canada. E398 700.3 Berlin Questionnaire Is a Useful Tool to Identify Risk of Obstructive Sleep Apnea in Metabolic Syndrome Patients. F.X. Cepeda, L. Virmondes, S. Rodrigues, A.C. Dutra-Marques, J.C. Carvalho, E. Toschi-Dias, M.N. Alves, M. Rondon, W.R. Lopes-Vicente, M.F. Hussid, G. LorenziFilho, I.C. Trombetta. Heart Institute (InCor), University of São Paulo Medical School, Brazil, Universidade Nove de Julho (UNINOVE), Brazil, School of Physical Education and Sports and University of São Paulo, Brazil. E399 700.4 Effect of Carotid Sinus Nerve Transection on Ventilation in Juvenile (P25) Male Sprague-Dawley Rats. P.M. Getsy, G.A. Coffee, S.J. Lewis. Case Western Reserve University. E400 700.5 Comparison of the Ventilatory Responses Elicited by Hypoxic Gas Challenge in Freely-Moving C57BL6 and A/J Male Mice. G.A. Coffee, P.M. Getsy, S.J. Lewis. Case Western Reserve University. E401 700.6 Cardiorespiratory Responses to Severe Arterial Hypoxemia with Increasing Remifentanil Plasma Concentrations in the Rabbit. A.W. Quail, D.B. Cottee, J.M. Johnstone, K. O’Hara, S.W. White. University of Newcastle, Australia. Channels (KV) E402 700.7 Voltage-Dependent K+ Suppress Hypoxia-Induced Elevation of [Ca2+]i in Rat Carotid Body Glomus Cells. J. Wang, J.O. Hogan, D. Kim. Rosalind Franklin University of Medicine and Science.

Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E407 701.1 Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Coexisting Metabolic Syndrome and Renovascular Disease in Swine. A. Eirin, X. Zhu, C.M. Ferguson, A.J. van Wijnen, A. Lerman, L.O. Lerman. Mayo Clinic. E408 701.2 Susceptibility to Pressure-Induced Renal Injury in DOCA-Salt vs. Angiotensin II Hypertensive Rats. A.J. Polichnowski, K. Griffin, P. Sethupathi, V. Patel, M. Patel, M. Picken, G. Williamson, A. Bidani. East Tennessee State University, Hines VA Hospital and Loyola University Chicago and Illinois Institute of Technology. E409 701.3 Imaging Renin Granule Exocytosis in Juxtaglomerular Cells by Total Internal Reflection (TIRF) Microscopy. M. Mendez. Henry Ford Hospital. E410 701.4 Direct Evidence That in Rat the Renal Interstitium Contracts in Vivo. M. Rodríguez-Martínez, J. López-Rodríguez, O. Flores-Sandoval, M.Z. CalvoTurrubiartes, L. LLamazares-Azuara. Faculty of Medicine UASLP, Mexico. E411 701.5 Adenosine A1 Receptor-Operated Calcium Entry in Renal Afferent Arteriolar Smooth Muscle Cells Is Dependent on Postnatal Maturation of Canonical Transient Receptor Potential Isoform 3 Channels. D. Peixoto-Neves, H. Soni, R.K. Buddington, A. Adebiyi. University of Tennessee Health Science Center and University of Memphis. E412 701.6 Role of Gap Junctions in Renal Vascular Conducted Response. S. Moller. University of Copenhagen, Denmark. E413 701.7 TRPV4 Channels Contribute to Renal Myogenic Response in Neonatal Pigs. H. Soni, D. Peixoto-Neves, A. Adebiyi. University of Tennessee Health Science Center. E414 701.8 A New View of Macula Densa Cell Biology. U. Shroff, L. Perin, J. Peti-Peterdi. University of Southern California.

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PHYSIOLOGY SUNDAY E415 701.9 Macula Densa Cell Gene Profiling. A. RiquierBrison, D. Desposito, J. Moon, J. Peti-Peterdi. University of Southern California. E416 701.10 Glucagon-Like Peptide-1 Affects Mean Arterial Pressure, Renal Blood Flow and Urinary Flow Rate in Spontaneously Hypertensive Rats Despite No Renal Expression of GLP-1 Receptors. C.M. Sorensen, J. Ronn, J.J. Holst, E.P. Jensen. University of Copenhagen, Denmark. E417 701.11 JGA-Derived CCN1 Is a Systemically Acting Angiogenic Hormone. D. Desposito, J. Moon, A. RiquierBrison, J. Peti-Peterdi. University of Southern California. E418 701.12 A New View of Macula Densa Cell Microanatomy. G. Gyarmati, J. Moon, A. Riquier Brison, J. Peti-Peterdi. University of Southern California.

702. PH HOMEOSTASIS AND ACIDBASE TRANSPORT Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E419 702.1 Renal Response to Acidosis: RNA-Seq and Role of NaDC1. S. Yadav, W. Huang, J. Coleman-Barnett, L. Hamm, K.S. Hering-Smith. Tulane University School of Medicine. E420 702.2 Renal Role of Gprc5c in Regulating Systemic pH Homeostasis. P. Rajkumar, B. Cha, M. Donowitz, Y. Hirabayashi, L.J. Arend, J.L. Pluznick. Johns Hopkins School of Medicine and RIKEN Brain Science Institute, Japan. E421 702.3 Characterization of pHi Regulation by NBCe1/ SLC4A4 Variants with Known Clinical Phenotypes in Human Immortalized Trabecular Meshwork Cells with a Red-Shifted Genetically-Encoded pH-Indicator “pHire”. A.J. Rossano, P.N. Caldas Font, H.L. Holmes, M.F. Romero. Mayo Clinic College of Medicine and University of Puerto Rico, Puerto Rico. E422 702.4 The Choroid Plexus Sodium-Bicarbonate Cotransporter NBCe2 Regulates Cerebrospinal Fluid pH. D. Barbuskaite, J. Praetorius, H.L. Christensen, A. Rojek, H.M. Nielsen, E. Fuchtbauer, T. Wang, H.H. Damkier. University of Copenhagen, Denmark and Aarhus University, Denmark. E423 702.5 Nominal Carbonic Anhydrase Activity Mitigates Airway-Surface Liquid pH Changes During the Respiratory Cycle. I.M. Thornell, X. Li, X. Tang, J.L. Zabner, M.J. Welsh. University of Iowa.

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703. EPITHELIAL TRANSPORT GROUP I Poster (Sponsored by: APS Epithelial Transport Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E424 703.1 Importance of Adenylyl Cyclase 6 in Developing Lithium-Induced Nephrogenic Diabetes Insipidus. S.B. Poulsen, T.B. Kristensen, H.L. Brooks, T. Rieg, R.A. Fenton. Aarhus University, Denmark, VA San Diego Healthcare System, University of Arizona and University of California San Diego. E425 703.2 Curation of Renal Inner Medullary Collecting Duct Proteome Database with Sequence-Based Searching Using K-Blast. B. Medvar, T. Pisitkun, A. Sarkar, M. Knepper. NHLBI, NIH and The Catholic University of America. E426 703.3 Intestinal Adenylyl Cyclase 6 Mediates Cholera Toxin-Induced Diarrhea. T. Rieg, I. Kaji, Y. Akiba, J. Kaunitz, S.B. Poulsen, J.A. Dominguez Rieg, R.A. Fenton. UCSD & VASDHS, UCLA & Greater LAVAHS, Aarhus University, Denmark and Bastyr University California. E427 703.4 ER and Mitochondria Regulate Intracellular Ca2+ and ENaC in Mouse Renal CCD Principal Cells. L.W. Li, L. Galarza-Paez, L. Zhou, V.A. Linck, B. Duke, O. Al-Khalili, T.L. Thai, D.C. Eaton. Emory University. E428 703.5 The Divergent Redox Sensitivities of d- and aEpithelial Sodium Channel (ENaC) Subunits. M.N. Helms, W. Wu. University of Utah and University of California San Diego. E429 703.6 H,K-ATPase Type 2 Participates in the Adaptive Proliferation of Quiescent Renal A-Type Intercalated Cells in Response to K+ Depletion. G. Crambert, L. Cheval, A. Doucet, A. Edwards, C. Walter. Centre de Recherche des Cordeliers - INSERM U1138 - CNRS ERL8228, France and Boston University. E430 703.7 Upregulation of miR-21-5p and VMP-1 Precede Apical Bleb Formation in Renal Ischemia. V. Singh, M. Paterson, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. E431 703.8 AVP Dynamically Increases Paracellular Na+ Permeability and Transcellular NaCl Transport in the Medullary Thick Ascending Limb of Henle’s Loop. J. Leipziger, N. Himmerkus, A. Plain, R.D. Marques, S. Sonntag, A. Paliege, M. Bleich. Aarhus University, Denmark, Chrisitan Albrechts University Kiel, Germany, Charité and Universitätsmedizin Berlin, Germany. E432 703.9 A Role for p38 in Bile Acid (BA)-Mediated Tight Junction (TJ) Dysfunction in Human Colon T84 Cells. T. Nair, H. Sirajuddin, M. Ao, S. Alendry, L. Haery, J. Domingue, M. Rao, J. Sarathy. Benedictine University and University of Illinois at Chicago. E433 703.10 Hydrophobic Residues in the Zonula Occludens-1 (ZO-1) ZU5 Domain Contribute to Essential Junctional Activity. J.M. King, N.C. Thomason, A.R. White, K.M. Kannen, L. Shen, J.R. Turner. Trinity Unversity, University of Chicago, Brigham and Women’s Hospital and Harvard Medical School. E434 703.11 Ischemia Leads to Increases in Tight Junction Mobility Following FRAP in Vivo. A. Kolb, K. Amsler, R. Bacallao. Indiana University Purdue University Indianapolis, Roudebush VAMC, NYIT College of Osteopathic Medicine and Indiana University School of Medicine.

SUNDAY PHYSIOLOGY E435 703.12 Identification of β-Catenin Interacting Proteins in the Nuclei of Native Rat Renal Inner Medullary Collecting Duct Cells. J. Hwang, H. Jung, C. Chou, M. Knepper. NHLBI and NIH. E436 703.13 Autophagy Prevents Downregulation of AQP1 Protein Induced by Ischemia/Reperfusion in Cultured IMCD3 Cells. Q. Liu, S. Hu, W. Dong, X. Liang, C. Li, W. Wang. Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, People’s Republic of China, Guangdong General Hospital, People’s Republic of China. E437 703.14 Altered Expression of Aquaporin Water Channels in a Rat Model of Chronic Diarrhea Due to Bile Acid Malabsorption. J. Yde, J. Borg, R.A. Fenton, H.B. Moeller. Aarhus University, Denmark. E438 703.15 Molecular Basis of AVP-Regulated Calcium Signaling in the Collecting Duct. M. Mamenko, I. Dhande, V. Tomilin, O. Zaika, P.A. Doris. The University of Texas Health Science Center at Houston, Medical College of Georgia and Augusta University. E439 703.16 A Study on Mechanism and Potential Application of Novel Chalconoid Derivatives as Anti-Secretory Therapy for Diarrheal Diseases. C. Yibcharoenporn, W. Chavasiri, V. Chatsudthipong, C. Muanprasat. Mahidol University, Thailand and Chulalongkorn University, Thailand. E440 703.17 Fungus-Derived Zearalenone as an Inhibitor of cAMP-Dependent Chloride Secretion in Human Colonic Epithelial T84 Cells. P. Muangnil, K. Tadpetch, V. Rukachaisirikul, V. Chatsudthipong, C. Muanprasat. Mahidol University, Thailand and Prince of Songkla University, Thailand. E441 703.18 A Screen for Potassium Sensitivity in Yeast Reveals Endosomal Sorting Factors That Regulate the Renal Outer Medullary Potassium (ROMK) Channel. T.D. Mackie, P.A. Welling, A.R. Subramanya, J.L. Brodsky. University of Pittsburgh and University of Maryland Baltimore. E442 703.19 Renal Epithelial Function Can Be Altered by Hypoxia Inducible Mechanisms. S.S. Nag, A.H. Resnick. Cleveland State University. E443 703.20 Effect of Diuretics and Gender on Kcnj16Mediated Effects in Salt Sensitive Hypertension. O. Palygin, V. Levchenko, O. Prudnikov, C. Nguyen, A. Staruschenko. Medical College of Wisconsin.

704. PROKARYOTIC TRANSPORT, METABOLISM, AND CELL SIGNALING IN NUTRITION, HEALTH, AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E444 704.1 Select Moringa oleifera Subfractions Exhibit Potent Antibacterial Properties Against Escherichia coli. T. Orders, S. Nair, B. Smith, J. Slate, N. Moreano, E. Oyugi, S. Reinker, Y. Salih, R. Maisura, A. Payne, J. Emrani, J. Idassi, M. Frank, C.N. Mowa. Appalachian State University and American Physiological Society.

E445 704.2 Death by a Thousand Cuts: Moringa oleifera Lysis Escherichia coli by Altering Multiple Biological Processes. B. Smith, T. Orders, J. Emrani, J. Idassi, M. Frank, C.N. Mowa. Appalachian State University, North Carolina A & T and American Physiological Society.

705. BLOOD BRAIN BARRIER, BRAIN BLOOD FLOW AND METABOLISM Poster (Sponsored by: APS Central Nervous System Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E446 705.1 Early Post-Ischemic Blood-Brain Barrier (BBB) Disruption in Long-Standing Obesity. C. Li, G. Xu, K.D. McCarter, H. Sun. Louisiana State University Health Sciences Center-Shreveport. E447 705.2 Oxygen Glucose Deprivation Modulates Endothelial Ca2+ Signal Mediated by TRPV4-KCa Channels. M.T. Lin, C. Choi, X. Zha, F. Yap. University of South Alabama. E448 705.3 Transcranial Direct Current Stimulation Transiently Increases the Blood-Brain Barrier Solute Permeability in Rat Brain. B. Fu, D. Shin, N. Khadka, J. Fan, M. Bikson. The City College of the City University of New York. E449 705.4 Changes in the Oxyhemoglobin Dissociation Curve and Cerebral Oxygenation During Acute Systemic Inflammation in Healthy Volunteers. R. Dahl, R. Plovsing, R. Berg. University Hospital Rigshospitalet, Denmark and Frederiksberg and Bispebjerg Hospitals, Denmark.

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706. AUTONOMIC CONTROL AND AUTOREGULATION OF THE CEREBRAL CIRCULATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E450 706.1 Cerebrovascular Responses to Trigeminal Nerve Stimulation in Humans. A. Ahmed, L. Edwards, I.D. Braz, J.P. Fisher. University of Birmingham, United Kingdom. E451 706.2 Impaired Dynamic Cerebral Autoregulation to Postural Stress Following Concussive Injuries in Adolescents. M.E. Moir, K.C. Abbott, C.S. Balestrini, L.K. Fischer, D.D. Fraser, J.K. Shoemaker. Western University, Canada and Children’s Health Research Institute, Canada. E452 706.3 Blast Exposure with mTBI Is Associated with Impaired Cerebral Blood Flow in US Veterans. J.M. Serrador, Y. Haber, K. Brewer, L. De La Cruz, M. Falvo. Dept of Veteran Affairs and Rutgers.

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707. ACUTE EXERCISE RESPONSES Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E453 707.1 Fatigue and Motor Unit Activation Are Determined by Neither Load Nor Time Under Tension During Resistance Exercise. R. Morton, M. Sonne, A. Farias Zuniga, A. Jones, P. Keir, C. McGlory, S. Phillips. McMaster University, Canada. E454 707.2 Effects of Resting Muscle Carnosine Content on the Intramuscular Antioxidant Response to a Bout of Resistance Exercise. A.N. Varanoske, J.R. Hoffman, D.D. Church, A.R. Jajtner, J.R. Townsend, K.S. Beyer, L.P. Oliveira, D.H. Fukuda, J.R. Stout. University of Central Florida. E455 707.3 IL-6 Contributes to Exercise Induced Recovery of Hepatic Insulin Action in Obese Mice. W.T. Peppler, R.E. MacPherson, M.R. Panasevich, G.M. Meers, R.S. Rector, D.C. Wright. University of Guelph, Canada, Brock University, Canada, University of Missouri and Harry S Truman Memorial VA Hospital. E456 707.4 Maturity Related Differences in Systemic and Localized Fatigue Thresholds Amongst Adolescent Male Athletes. K.S. Beyer, J.R. Stout, M.J. Redd, K.M. Baker, D.H. Fukuda, J.R. Hoffman. University of Central Florida. E457 707.5 Physical Capacity and Energy Expenditure of Cavers. v. Pinna, S. Magnani, G. Sainas, G. Gihiani, S. Vanni, F. Tocco, G. Antoni, A.C. Rinaldi, A. Crisafulli. University of Cagliari, Italy. E458 707.6 Effects of the Different Acute Exercise on Serum Cortisol of Undergraduate. J. He, P.Y. Sun, L.L. Qiu. East China Normal University, People’s Republic of China. E459 707.7 Single- vs. Double-Leg Cycling: Lower Cardiorespiratory Demands and Perceived Effort for a Greater Relative Power Output. M.J. MacInnis, N. Morris, M.W. Sonne, A. Farias Zuniga, P.J. Keir, J.R. Potvin, M.J. Gibala. McMaster University, Canada. E460 707.8 Single Bout of Moderate-Intensity Exercise Facilitates Memory Consolidation via New Protein Synthesis in Dorsal Hippocampal CA. K. Inoue, A. Yamaguchi, I. Morita. Health Sciences University of Hokkaido, Japan. E461 707.9 Effects of the Different Acute Exercise on Melatonin of Undergraduate. Y. Sun, J. He, L. Qiu. East China Normal University, People’s Republic of China. E462 707.10 PGC-1α–Dependent TFEB Expression and Activation with Exercise. A.T. Erlich, D. Brownlee, K. Beyfuss, D. Hood. York University, Canada. E463 707.11 Dynamics of Locomotor Fatigue During SupraCritical Power Exercise in Humans. A. Swisher, B. Koehn, S. Yong, J. Cunha, C. Ferguson, D.T. Cannon. San Diego State University and University of Leeds, United Kingdom. E464 707.12 Factors Predictive of Human One-Kilometer Ice Swimming Race Time Performance. C.A. Wulf, S.P. Treu, T. Wilson. Winona State University. E465 707.13 Active Video Gaming Compared to Treadmill Walking and TV Watching in Obese Children and Adolescents. W. Smith, R.A. Moran, C.A. Fu, T.A. Scott. University of Tennessee Health Science Center and LeBonheur Children’s Hospital.

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E466 707.14 Predicting Mountain Ultra-Marathon Performance Using the Critical Velocity Model. M. Rogers, M. Ngo, O. Sandberg, P. Atashzay, P. Singh, C. Malcolm, D. Clarke, M. Walsh, M. White. Simon Fraser University, Canada. E467 707.15 Does Maximal Isokinetic Power at Exercise Intolerance Approximate Critical Power? S. Yong, A. Swisher, C. Ferguson, D.T. Cannon. San Diego State University and University of Leeds, United Kingdom. E468 707.16 Aortic Pulsatility and Arterial Stiffness After Acute Combined Resistance and Endurance Exercise. T.R. Wakeham, I.M. Greenlund, J.J. Durocher. Michigan Technological University. E469 707.17 Exercise-Induced Expression, Function, and Localization of Protein Arginine Methyltransferases in Skeletal Muscle. T.L. van Lieshout, D.W. Stouth, V. Ljubicic. McMaster University, Canada.

708. AUTONOMIC ADJUSTMENTS TO EXERCISE Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E470 708.1 Blunted Autonomic Response to Head Up Tilt in Individuals with Intellectual Disabilities: Preliminary Results. T. Hilgenkamp, E.C. Schroeder, D.W. White, T. Baynard, B. Fernhall. University of Illinois at Chicago, Erasmus MC University Medical Center Rotterdam, Netherlands and University of Houston-Victoria. E471 708.2 Pedometer-Determined Physical Activities of Daily Living Can Affect Blood Pressure Regulation in Healthy Young Adults After Postural Change. H. Yang, Y. Kotaki, J. Hoshi, S. Bao, H. Tanno, E. Kanno, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E472 708.3 Exercise Training Intolerance in Heart Failure with Preserved Ejection Fraction Is Associated with Altered Chemoreflex Gain and Sympathoexcitation in Rats. D.C. Andrade, A. Arce-Alvarez, C. Toledo, H. Diaz, C. Lucero, M. Faundez, R. Iturriaga, R. Del Rio. Pontificia Universidad Catolica de Chile, Chile and Universidad Autonoma de Chile, Chile. E473 708.4 Combined Exercise Training Atenuates the Onset of Cardiometabolic and Autonomic Dysfunctions in an Experimental Model of Metabolic Syndrome. D. Dias, N. Bernardes, F.F. Conti, J.d. Brito, F. Santos, A.A. Araujo, D.M. Oliveira, N. Frisene, M. Irigoyen, K. De Angelis. Universidade Nove de Julho, Brazil and Medical School of University of Sao Paulo, Brazil. E474 708.5 Muscle Sympathetic Nerve Responses to Passive and Active One-Legged Cycling: Insight Into the Contributions of Central Command. C.J. Doherty, A.V. Incognito, K. Notay, M.J. Burns, M. Nardone, J.D. Seed, P.J. Millar. University of Guelph, Canada and University of GuelphHumber, Canada.

SUNDAY PHYSIOLOGY E475 708.6 Linear and Nonlinear Analysis of Heart Rate Variability in an Experimental Model of Diabetes and Obesity Submitted to Myocardial Infarction: Role of Aerobic Exercise Training. F.F. Conti, M. Sartori, F. Santos, D.S. Dias, J.F. Machi, L.E. Souza, Jensen, M. Morris, M. Irigoyen, K. De Angelis. Universidade Nove de Julho, Brazil, Universidade of São Paulo, Brazil and Nova Southeastern University. E476 708.7 Autonomic Cardiovascular Response During the Isometric Cuban Test of the Sustained Weight. M. SanchezHechavarria, R. Carrazana-Escalona, B. Ricardo-Ferro, I. Cutino-Clavel, E. Lopez-Galan. University of Santiago de Cuba, Cuba. E477 708.8 Inter-Individual Variability in Muscle Sympathetic Nerve Activity During Static Handgrip in Healthy Young Men. A.V. Incognito, C.J. Doherty, J.B. Lee, M.J. Burns, P.J. Millar. University of Guelph, Canada.

709. ALTITUDE AND HYPOXIA AND RESPIRATORY RESPONSES TO EXERCISE Poster (Sponsored by: APS Environmental and Exercise Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E478 709.1 Withdrawn. E479 709.2 Altered Hypoxia-Induced Vascular Reactivity and Endothelial Repair Capacity in Hypertensive Men. H.N. Rocha, V.P. Garcia, J.D. Mattos, M.P. Rocha, M.O. Campos, D.E. Mansur, A.L. Nóbrega, I.A. Fernandes, N.G. Rocha. Fluminense Federal University, Brazil. E480 709.3 Acute Hypoxia Decreases Systemic Blood Pressure at Exercise in Hypertensive and Normotensive Subjects. J. Richalet, L. Winkler, F.J. Lhuissier. Université Paris 13, Sorbonne Paris Cité and, France. E481 709.4 Higher Protein Diet Suppresses Appetite at High Altitude. J. Karl, R.E. Cole, C.E. Berryman, M.T. Kominsky, P.N. Radcliffe, L.M. Margolis, A.J. Young, S.M. Pasiakos. US Army Research Institute of Environmental Medicine and Oak Ridge Institute of Science and Education. E482 709.5 Molecular Basis of Hypoxia Induced Excessive Erythrocytosis. P. Azad, G. Haddad. University of California San Diego. E483 709.6 Poincare Analysis of Spontaneous Respiratory Sinus Arrhythmia During High Altitude Ascent: Effects on Oxygenation. G. Saran, L. Lavoie, A. Linares, J. Pfoh, C. Bruce, K. Borle, R. Brandt, K. Tjandra, T.A. Day. Mount Royal University, Canada. E484 709.7 Effects of Transitioning from Un-Occluded to Occluded Hyperbolic Submaximal Exercise on VO2 Mean Response Time and Oxygen Deficit. E.H. Van Iterson, T.P. Olson. Mayo Clinic. E485 709.8 Habitual Physical Activity Level Modifies Lung Function, but Not 8-Isoprostane Generation, in Older Adults. S.P. Kurti, S.R. Emerson, S.K. Rosenkranz, J.R. Smith, C.A. Harms. Kansas State University. E486 709.9 Imposed Expiratory Resistance, Hyperinflation, and Dyspnea Are Dissociated from Locomotor Fatigue During Moderate Exercise. B.E. Wickman, K.G. Sasaki, E. TorrecillasSanchez, D.T. Cannon. San Diego State University.

710. MUSCLE PHYSIOLOGY: REGULATION OF CONTRACTION, OXIDATIVE STRESS AND OXYGEN DELIVERY Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E487 710.1 Determinants of Skeletal Muscle Work Efficiency in Patients with COPD. G. Layec, C.R. Hart, J. Trinity, Y. Le Fur, E. Jeong, R. Richardson. University of Utah and University of Aix-Marseille, France. E488 710.2 Muscle Recruitment Patterns Above Critical Power. A.M. Alexander, S.M. Hammer, K.D. Didier, D.R. Baumfalk, T.J. Barstow. Kansas State University. E489 710.3 Active Shortening Protects Against StretchInduced Force Deficits in Human Skeletal Muscle. A.L. Saripalli, K.B. Sugg, C.L. Mendias, S.V. Brooks, D.R. Claflin. University of Michigan. E490 710.4 Myosin Phosphorylation-Mediated Potentiation Does Not Alter the Economy of Work Performed in Fast Skeletal Muscles. W. Gittings, J. Bunda, R. Vandenboom. Brock University, Canada. E491 710.5 Increased Superoxide Dismutase-2 in Skeletal Muscle in a Rat Model of Preterm Birth. E.S. Hokanson, L. Tetri, R.K. Braun, M.W. Eldridge. University of WisconsinMadison and UW Madison. E492 710.6 Human Skeletal Muscle Proteins and Metabolic Pathways Are Susceptible to Dicarbonyl Stress. J.T. Mey, J.M. Haus. University of Illinois at Chicago. E493 710.7 Muscle Inflammatory Signaling’s Contribution to Cancer Cachexia-Induced Decrements in Muscle Function. B. VanderVeen, J. Hardee, D. Fix, J. Carson. University of South Carolina. E494 710.8 Short Term High Fat Feeding Alters Expression of Glucoregulatory Proteins in Skeletal Muscle of Male Adolescent Rats. M.S. Crawford, T. Liss, K. Sweazea. Arizona State University. E495 710.9 Whole Body Hyperthermia Enhances Angiogenesis in Tenotomized Rat Skeletal Muscle. M. Hirunsai, R. Srikuea. Srinakharinwirot University, Thailand and Mahidol University, Thailand. E496 710.10 Metabolic Demand Dictates Muscle Blood Flow and the Hyperemic Response to Low Intensity Exercise. A. Tonson, J. Kasper, D. Tanbakuchi, R. Meyer, R. Wiseman. Michigan State University. E497 710.11 Nitrite Infusion Does Not Alter Isolated Canine Muscle Oxidative Metabolism in Situ During Hypoxia with Normal Convective O2 Delivery. S. Porcelli, L. Rasica, B.S. Ferguson, A.N. Kavazis, J.R. McDonald, F. Mowry, M.C. Hogan, B. Grassi, B.L. Gladden. National Research Council, Italy, University of Milan, Italy, Italian National Research Council, Italy, University of Illinois, Auburn University, University of California San Diego and University of Udine, Italy.

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711. REDUCED GRAVITY AND HYPERBARIC ENVIRONMENTS Poster

Poster

(Sponsored by: APS Environmental and Exercise Physiology Section)

(Sponsored by: APS Environmental and Exercise Physiology Section)

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:45 pm–3:00 pm

Presentation time: 12:45 pm–3:00 pm

E498 711.1 Carotid Artery Structure During and After Long-Duration Space Flight. S.M. Lee, D.S. Martin, S.S. Laurie, L.C. Ribeiro, S.M. Smith, S.R. Zwart, M.B. Stenger. KBRwyle, NASA Johnson Space Center and University of Texas Medical Branch. E499 711.2 Development of a Chronic Irradiation and Simulated Microgravity Facility. P. Chowdhury, R.J. Griffin, G. Narayanasamy, R. Pathak, M. Hauer-Jensen, M. Boerma, M. Dobretsov. University of Arkansas for Medical Science. E500 711.3 Hindlimb Suspension as a Model for Intracranial and Intraocular Pressures, and Retinal Changes During Spaceflight. C.A. Fuller, H. Gompf, T. Hoban-Higgins, E. Robinson. University of California at Davis. E501 711.4 High Air-Pressure Elevated Energy Expenditure in Mice. D. Xiang, Y. Fang, B. Luo, S. Yan, J. Xu, P. Chen. Naval Medical Research Institute, People’s Republic of China, and Shanghai University of Sport, People’s Republic of China. E502 711.5 Singlet Oxygen Production in the Caudodorsal Medulla of Rat Brain Slices Increases During Hyperoxia at Normobaric Pressure and Following Decompression from IsoOxic Hyperbaric Nitrogen. T.R. Roberts, G.E. Ciarlone, J.B. Dean. University of South Florida and US Army Institute of Surgical Research. E503 711.6 Reevaluation of CNS Oxygen Toxicity Seizures in Male Sprague-Dawley Rats. C.M. Hinojo, N.M. Stavitzski, C.S. Landon, J.B. Dean. University of South Florida. E504 711.7 Investigating the Effects of Hyperbaric Oxygen on Mitochondrial Function of Endothelial Progenitor Cells. N. Aylin-Burns, K.J. Krager, D. Zhou, M. Hauer-Jensen. University of Arkansas for Medical Sciences. E505 711.8 Can Hyperoxia and Hyperbaric Conditions Induce a Increase in Systemic Pressures (SBP, DBP, MAP) to the Breathing of 100 Percent Oxygen at Normal and Hyperbaric Barometric Pressure? A. Duvallet, E. Duvallet, F. Lhuissier, P. Constantin, M. Beaudry. Hopital Avicenne, APHP, Paris, France, VeroScience, Sorbonne-Paris-Cité, Université Paris 13, France, Hôpital Avicenne, APHP, Paris, France, Metropolitan and CMA Marseille-Aubagne, France.

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712. NEURAL CONTROL OF THE CIRCULATION DURING EXERCISE

E506 712.1 Passive Heating Impairs Cardiac Autonomic Regulation During Exercise and Post-Exercise Recovery. T. Peçanha, C. Forjaz, D. Low. University of Sao Paulo, Brazil and Liverpool John Moores University, United Kingdom. E507 712.2 Lumbar Sympathetic Nerve Activity at Rest and During Muscle Contraction: Effects of Estrogen and Nitric Oxide. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E508 712.3 Estrogen and Neuronal Nitric Oxide-Mediated Inhibition of Sympathetic Vasoconstriction. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E509 712.4 Sex Differences in Sympathetic Vasoconstrictor Responsiveness and Sympatholysis. T.P. Just, D.S. DeLorey. University of Alberta, Canada. E510 712.5 Role of Alpha-Adrenergic Vasoconstriction in Regulating Skeletal Muscle Blood Flow During Single Leg Knee Extension Exercise with Advancing Age. S.M. Ratchford, H.L. Clifton, Z.M. Barret-O’Keefe, R.M. Broxterman, J.R. Gifford, J.R. Hydren, M.J. Rossman, S.J. Ives, J.D. Trinity, M.A. Witman, R.S. Garten, D.E. Morgan, A.D. Nelson, R.S. Richardson, D.W. Wray. University of Utah and VA Medical Center. E511 712.6 Functional Sympatholysis Is Impaired in EndStage Renal Disease. R. Downey, H. Lee, P. Liao, D. DaCosta, J. Park. Emory University and Atlanta VA Medical Center. E512 712.7 The Role Played by Oxidative Stress in Evoking the Exercise Pressor Reflex in Health and Simulated Peripheral Artery Disease. J.E. Harms, J.S. Kim, J.M. Kuczmarski, G.D. Thomas, M.P. Kaufman. Penn State University College of Medicine. E513 712.8 Revisiting “Resetting” of Baroreflexes During Canine Exercise. R.D. Wurster. Loyola University Chicago. E514 712.9 Effect of Endurance Training on the Centrally Induced Muscle Vasodilatation During One-Legged Cycling. R. Asahara, K. Matsukawa, T. Shintaku. Hiroshima University, Japan. E515 712.10 Early Stage Type 1 Diabetes Augments the Mechanoreflex in Rats. E.A. Garcia, A. Grotle, A.J. Stone. University of Texas at Austin. E516 712.11 Similar Effects of Type 1 Diabetes on the Pressor Reflex in Male and Female Rats. A. Grotle, E.A. Garcia, A.J. Stone. University of Texas at Austin. E517 712.12 Effects of Type 1 Diabetes on the Exercise Pressor Reflex in Rats. A.J. Stone, A. Grotle, E.A. Garcia, M.L. Harrison. University of Texas at Austin. E518 712.13 Exaggerated Sympathetic and Pressor Responses to Exercise Pressor Reflex Activation Are Attenuated by Intracerebroventricular Insulin Administration in Type 2 Diabetic Rats. M. Mizuno, J. Mitchell, S.A. Smith. UT Southwestern Medical Center.

SUNDAY PHYSIOLOGY E519 712.14 ATP-Sensitive K+ Channel Inhibition via Glibenclamide Does Not Increase Lumbar or Renal Sympathetic Nerve Discharge in Healthy Rats. T.D. Colburn, C.T. Holdsworth, J.C. Craig, D.M. Hirai, S. Montgomery, M.J. Kenney, T.I. Musch, D.C. Poole. Kansas State University. E520 712.15 Chronic Femoral Artery Ligation Exaggerates the Exercise Pressor Reflex But Not Selective Activation of the Muscle Mechanoreflex in Decerebrate Rats. K.S. Rollins, P.J. Esau, S.W. Copp. Kansas State University. E521 712.16 Contribution of Prostaglandins to the Inspiratory Muscle Metaboreflex-Induced Cardiovascular Consequences. J.R. Smith, K.D. Didier, S.M. Hammer, A.M. Alexander, S.P. Kurti, T.J. Barstow, C.A. Harms. Kansas State University. E522 712.17 Rna-Sequence Analysis Reveals Unique Changes in the Dorsal Root Ganglia Transcriptome of Rats with Femoral Artery Occlusion. J.M. Kuczmarski, K. Unrath, Y. Imamura, G.D. Thomas. Penn State College of Medicine. E523 712.18 Expression and Distribution of ProInflammatory Cytokines Within Dorsal Root Ganglion of Rats with Femoral Artery Occlusion. J. Li, J. Lu, J. Xing. Penn State College of Medicine, The First Hospital of Jilin University, Jilin University, People’s Republic of China. E524 712.19 The Postexercise Pressor Reflex Is Influenced by Pedal Frequency During Low Intensity Ergometry in Normotensive Healthy Adults. N.R. Randall, E.H. Van Iterson, N. Villarraga, B. Ziegler, T.P. Olson. Mayo Clinic. E525 712.20 Combined Influences of Subsystolic Regional Circulatory Occlusion and Pedal Rate on the Exercise Pressor Reflex in Healthy Adults. N. Villarraga, E.H. Van Iterson, N. Randall, B. Ziegler, T.P. Olson. Mayo Clinic.

713. THE EFFECTS OF AGING ON MUSCLE FUNCTION Poster (Sponsored by: APS Muscle Biology Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E526 713.1 AdipoRon, Pan-Adiponectin Receptor Agonist, Activates Mitochondrial Metabolism via AMPK-PGC1α Pathway in the Skeletal Muscle. P. Balasubramanian, P. Howell, S. Martin, R. Anderson. University of Wisconsin-Madison. E527 713.2 Estradiol Deficiency Leads to High miR21 Level in Skeletal Muscle of Ovariectomized Mice. S.M. Karvinen, E. Laakkonen, G. Le, B.C. Collins, T.L. Mader, D. Lowe. University of Jyväskylä, Finland and University of Minnesota. E528 713.3 Dietary Nitrate and Skeletal Muscle Recovery After Injury in Young and Old Mice. D. Hahn, R. Patel, R.C. Kelley, P.D. Coblentz, L.F. Ferreira. University of Florida. E529 713.4 Muscle-Specific Calpastatin Overexpression Prevents Sarcopenia of Aging. E.A. Schroder, X. Song, L. Wang, G.S. Supinski, L. Callahan. University of Kentucky. E530 713.5 Age-Related Alterations in Cutaneous Vascular and Sweating Responses Depend on Sex and Types of Receptor Agonist. N. Fujii, B.D. McNeely, L. Halili, S.Y. Zhang, M.O. Danquah, G.P. Kenny. University of Ottawa, Canada and University of Tsukuba, Japan.

E531 713.6 The Effects of Low-Intensity Exercise During Bed Rest in Healthy Older Adults. F. Galvan, E. ArentsonLantz, S. Nagamma, R.R. Deer, C.S. Fry, A. Wacher, D. Paddon-Jones. University of Texas Medical Branch (UTMB). E532 713.7 PGC-1α Upregulates Mitochondrial Sirtuins and Reduces Protein Acetylation in Skeletal Muscle of Old Mice. C. Kang, D. Yeo, L. Ji. University of Minnesota-Twin Cities and University of Minnesota. E533 713.8 Testing the Efficacy of β-Hydroxy-βMethylbutyrate (HMB) to Preserve Mitochondrial Function in Aging Drosophila melanogaster. D.M. Callahan, A.F. Mead, D.W. Maughan. University of Vermont. E534 713.9 p16 and γH2AX as Markers of Cellular Senescence in Young and Old Human Skeletal Muscle. C. Dungan, K. Kosmac, B. Peck, J. McCarthy, C. Peterson. University of Kentucky. E535 713.10 Satellite Cell-Mediated Myonuclear Accretion Is Required for Mechanical Overload-Induced Hypertrophy in Young Growing Mice. K. Murach, S. White, Y. Wen, A. Ho, K. Kosmac, J. McCarthy, C. Peterson. University of Kentucky. E536 713.11 Parkin Overexpression Attenuates AgingRelated Muscle Atrophy in Mice. O. Reynaud, J. LeducGaudet, S.N. Hussain, G. Gouspillou. Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Canada, UQAM, Canada, Groupe de Recherche en Activité Physique Adaptée, Canada, Meakins-Christie Laboratories, Departement of Critical Care, Canada and Research Institute of the McGill University Health Centre, Canada. E537 713.12 Sestrin 2 and 3 Gene Expressions Correlate with Homeostasis Model Assessment of Insulin Resistance and Beta Cell Secretory Status in Older Men. N. Zeng, P. Sharma, F. Ramzan, S.M. Mitchell, R.F. D’Souza, U. Prodham, A.M. Milan, C.J. Mitchell, D. Cameron-Smith. University of Auckland, New Zealand. E538 713.13 Fn14 Expression Is Lower in Female Compared to Male Skeletal Muscle, Independent of Adult Age. J. Blum, H. Roman, A. Thalacker-Mercer. Cornell University.

714. NEUROENDOCRINOLOGY, HYPOTHALAMUS AND PITUITARY Poster (Sponsored by: APS Endocrinology and Metabolism Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E539 714.1 Exploring the Role of Pituitary Kisspeptin Receptor on Gonadotrophic Function in Vivo and in Vitro. O. Awe, Y. Ma, A. Wolfe. Johns Hopkins School of Medicine, Affiliated Hospital of Jiangnan University, People’s Republic of China. E540 714.2 Aberrant Light-Induced Depression Is Associated with Decreased Adult Hippocampal Neurogenesis in Mice. L.J. Massman, W.C. Engeland, P. Kofuji. University of Minnesota. E541 714.3 Identification of a Novel Regulator of Vasopressin Secretion. L.M. Stein, J. Soo, S. Loewen, C. Hindmarch, A. Ferguson, G. Yosten, W. Samson. Saint Louis University, University of Pennsylvania and Queens University, Canada.

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PHYSIOLOGY SUNDAY E542 714.4 Copeptin: More Than Just a Surrogate Biomarker. C.J. Haddock, H.M. Wille, G.L. Yosten, W.K. Samson. Saint Louis University. E543 714.5 Hypothalamic Pathways Involved in Adenosine A1 Receptor Agonist-Induced Hibernation in the Arctic Ground Squirrel (Urocitellus paryii). C. Frare, K.L. Drew. University of Alaska Fairbanks.

715. PANCREATIC HORMONES, GLUCOSE HOMEOSTASIS, AND DIABETES Poster (Sponsored by: APS Endocrinology and Metabolism Section)

716. DIABETIC RENAL DISEASE Poster (Sponsored by: APS Renal Section)

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:45 pm–3:00 pm

Presentation time: 12:45 pm–3:00 pm

E544 715.1 Determining the Role of CEBP/α in Functional β-Cell Mass. K.B. Kener, J.D. Ray, M. Ballard, W. Utsch, J.S. Tessem. Brigham Young University. E545 715.2 Proinsulin C-Peptide Effects in Retinal Pigment Epithelium Health and VEGF Release: Implications for Diabetic Retinopathy. S.M. Grote, G.R. Kolar, G.L. Yosten. Saint Louis University School of Medicine. E546 715.3 The Cellular Response to C-Peptide Is Dependent on the Concentration of Glucose and Insulin. J.L. Rossiter, G.R. Kolar, G.L. Yosten. St Louis University. E547 715.4 Knockout of miR-223 Induces Beta-Cell Dysfunction Through Activation of the FOXO1 Signaling Pathway. Y. Li, J. Peng, S. Deng, X. Wang, D. Kuhel, J. Cash, K. Essandoh, X. Mu, E. Salem, D. Hui, G. Fan. University of Cincinnati. E548 715.5 Orphan Nuclear Hormone Receptor Small Heterodimer Partner Plays a Protective Role in Diet-Induced Islet Dysfunction. J. Park, M. Lee, Y. Lee. Northeast Ohio Medical University. E549 715.6 Free Fatty Acid Receptor 3 Plays a Role in High Fat Diet Induced β Cell Dysfunction and β Cell Stress. M. Priyadarshini, A.E. Ludvik, C. Cole, M. Newman, B.T. Layden. University of Illinois at Chicago, Northwestern University and Jesse Brown Veterans Affairs Medical Center. E550 715.7 Cytokines Activate Src Kinase and Inhibit EGFR-Mediated Repair Mechanisms via Mig6 in Pancreatic Beta Cells. K.M. Fong, A. Rezaeizadeh, Y. Chen, P.T. Fueger. Indiana University School of Medicine and City of Hope. E551 715.8 Low Phosphorus Diet Enhances Insulin Sensitivity. Y. Lin, L. Berger, Z. Sun. University of Oklahoma HSC. E552 715.9 Short-Term Metformin and Exercise Training Effects on Strength, Aerobic Capacity, Glycemic Control and Mitochondrial Function in Burn Children. E. Rivas, C. Porter, D.N. Herndon, O.E. Suman. The University of Texas Medical Branch and Shriners Hospitals for Children. E553 715.10 AICAR Attenuates Olanzapine-Induced Hyperglycaemia and Insulin Resistance in C57BL6 Mice. N. Bush, L. Castellani, D.C.Wright. University of Guelph, Canada. E554 715.11 Hypomagnesemia in Type 2 Diabetes Is Correlated with Insulin Resistance and Changes in Lipid Metabolism in Patients and Mice. S. Kurstjens, J. de Baaij, J. van Diepen, C. Overmars-Bos, H. Bouras, R. Bindels, C. Tack, J. Hoenderop. Radboudumc Nijmegen, Netherlands.

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E555 715.12 Hepatic Androgen Receptor Modulates Hyperandrogenemia-Induced Glucose Metabolic Dysfunction and Hepatic Insulin Resistance. S. Andrisse, S. Wu. Johns Hopkins University School of Medicine. E556 715.13 Raw Garlic Aqueous Extract (RGAE) Augments MafA Expression in the Liver of STZ-Induced Type-1 Diabetic Rats. K.K. Al-Qattan, A. Al-Otaibi, A. Al-Adsani, M. Al-Bader, M. Thomson, S.J. Divya, L. Miranda, S. Al-Bustan. Kuwait University, Kuwait.

E557 716.1 Effect of Resistance Exercise Training in Mitophagy of Diabetic Rats. l. Jorge, K.A. Silva, R.S. Luiz, R.R. Rampaso, N. Schor. Federal University of Sao Paulo, Brazil. E558 716.2 Modeling the Effects of Functional Adaptation to Reduction in Renal Mass. A. Layton, A. Edwards, V. Vallon. Duke University, Boston University and University of California San Diego. E559 716.3 In Vivo Knockdown of I-mfa Using the Targeted Nanoparticle Delivery System Ameliorated Renal Injury in Diabetic Mice. Y. Ma, W. Li, H. Jiang, Y. Wang, J. Zuckerman, M. Davis, R. Ma. University of North Texas Health Science Center, Anhui Medical University, People’s Republic of China, and California Institute of Technology. E560 716.4 Renal Olfactory Receptor 1393 May Contribute to the Progression of Diabetic Nephropathy. B.D. Shepard, J.L. Pluznick. Johns Hopkins University School of Medicine. E561 716.5 Polyphenolics Protect Renal Fibroblasts from the Harmful Effects of Hyperglycemia-Stimulated Advanced Glycation End Products. J.M. Harris, M.A. Blount. Emory University School of Medicine. E562 716.6 GYY4137 Modulates Plasminogen Activator Inhibitor-1-Dependent Extracelluar Matrix Turnover in Diabetic Kidney via RAR/RXR Signaling. A. Papu John, S. Pushpakumar, U. Sen. University of Louisville. E563 716.7 Fibroblast Growth Factor 1 Ameliorates Diabetic Nephropathy Through an Anti-Inflammatory Mechanism. Q. Lin, L. Cai, Y. Tan. University of Louisville. E564 716.8 Up-regulation of Transforming Growth FactorBeta via Advanced Glycation End Products-Induced Oxidative Stress on NRK-52E Cells. S. Jeong, S. Yang, K. Lee. Korea University, Republic of Korea. E565 716.9 Nox 4 Null Mutation Attenuates Podocyte Calcium Regulation Dysfunction and Kidney Damage in Streptozotocin-Treated Dahl Salt-Sensitive Rats. G. Blass, D. Ilatovskaya, K. Winsor, V. Levchenko, O. Palygin, A.W. Cowley Jr., A. Staruschenko. Medical College of Wisconsin. E566 716.10 Biomarkers of Kidney Injury and Indicators of Renal Inflammation in African American Men with Diabetes and Diabetic Nephropathy. L. Premadasa, A.M. Boston, R. Sedighi, G.E. Crawford, J. Pinder, O.E. Jegede, S.H. Harrison, R.H. Newman, E.M. Ongeri. North Carolina A&T State University and Cone Health Community Health and Wellness Center.

SUNDAY PHYSIOLOGY E567 716.11 Transcriptional Regulation and Therapeutic Targeting of P2X7 Receptors in Diabetic Nephropathy. R.I. Menzies, J.W. Booth, J.J. Mullins, M.A. Bailey, F.W. Tam, J.T. Norman, R.J. Unwin. University of Edinburgh, United Kingdom, UCL, United Kingdom and Imperial College London, United Kingdom. E568 716.12 Correlations Between Biomarkers of Kidney Injury, Adiponectin, and TGF?β1 in African American Men with Diabetes. A.M. Boston, L.S. Premadasa, R. Sedighi, G. Crawford, J. Pinder, S. Whitaker, O.E. Jegede, S.H. Harrison, R.H. Newman, E.M. Ongeri. North Carolina A&T State University and Cone Health Community Health and Wellness Center. E569 716.13 Suppression of Albumin-Induced Matrix Metalloproteinase-9 by Rosiglitazone in Renal Tubular Epithelial Cells. A. Cobbs, X. Chen, A. Khamdy, A. Chima, J. George, X. Zhao. Morehouse School of Medicine. E570 716.14 MicroRNA-21 Ablation Exacerbates Aldosterone-Mediated Renal Injury. S.L. Njemanze, M. Syed, L. Ramachandran Nair, J.P. Ball, K.W. Mathis, M.J. Ryan, M.E. Rothenberg, L.L. Yanes Cardozo, D.G. Romero. University of Mississippi Medical Center and Cincinnati Children’s Hospital. E571 716.15 Novel Differences in Renal Gene Expression in a Diet Induced Obesity Model of Diabetic Nephropathy. V.L. Halperin Kuhns, J.L. Pluznick. Johns Hopkins University. E572 716.16 Metformin Normalises Medullary Hypoxia in the Diabetic Rat Kidney. M. Christensen, T. Schiffer, R. Nørregaard, F. Palm. Aarhus University, Denmark and Uppsala University, Sweden.

717. AUTONOMIC ADJUSTMENTS TO BEHAVIORAL STRESS AND NEUROENDOCRINE ACTIVATION Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E573 717.1 Preproglucagon Neurons in the Brainstem Regulate Glucose Homeostasis and Insulin Sensitivity. X. Shi, S. Chacko, A. Brown, D. Li, F. Li, X. Guan. Baylor College of Medicine, Binzhou Medical University Hospital, People’s Republic of China, and the University of Texas MD Anderson Cancer Center. E574 717.2 Effects of Catecholamines on Gastric Functions in Stressed Rats. Y. Jiang, K.N. Browning, L. Toti, R. Travagli. Penn State College of Medicine. E575 717.3 A Ventral Medial Prefrontal Cortex– Dorsomedial Hypothalamus Monosynaptic Pathway That Drives Sympathetic Stress Responses. N. Kataoka, K. Nakamura. Nagoya University Graduate School of Medicine, Japan and JST, Japan. E576 717.4 The Relaxation Effects of Hand-Massage Therapy on Autonomic Nervous System Function and Emotions: Increases in Eye Contact and Communication. T. Sato, S. Bao, J. Hoshi, H. Yang, H. Tanno, E. Kanno, R. Maruyama. Tohoku University Graduate School of Medicine, Japan. E577 717.5 Method for Simultaneous Measurement of Amygdala Neuronal and Sympathetic Nerve Activity in Freely Moving Rats. K. Shizuka, M. Yoshimoto, F. Ootsuki, K. Miki. Nara Women’s University, Japan.

E578 717.6 Four Weeks of Exposure to Environmentally Relevant Levels of Second Hand Smoke Decreases Heart Rate Variability—but Not Baroreflex Sensitivity—in Mice. E. Karey, S. Pan, Y. Chen, K.E. Pinkerton, C. Chen. UC-Davis. E579 717.7 Pressor Hyperreactivity to Stress Corresponds to Greater Vasoconstriction and Sympathetic Responsiveness and Is Prevented by Renal Denervation. M.M. Knuepfer, S.K. Burris, J.L. Perry. St. Louis University School of Medicine, St. Louis University, Loyola University Strich School of Medicine and St. Louis University School Medicine.

718. ION CHANNEL MODULATION: CONTRIBUTIONS TO AUTONOMIC DYSFUNCTION IN CARDIOVASCULAR AND METABOLIC DISEASES? Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm E580 718.1 Chronic Hypertension Switches IrritantInduced Pulmonary-Cardiac Reflexes to Sympathoexcitation. T. Taylor-Clark, J.S. Hooper. University of South Florida. E581 718.2 Neuronal Nitric Oxide Synthase Inhibits StoreOperated Ca2+ Entry in Cardiomyocytes via S-Nitrosylation of Stromal Interaction Molecule-1. Q. Feng, L. Gui, J. Zhu, X. Lu, S.M. Sims, W. Lu, P.B. Stathopulos. University of Western Ontario, Canada, Nantong University Medical School, People’s Republic of China. E582 718.3 Hydrogen Peroxide Inhibits Neurons in the Paraventricular Nucleus of the Hypothalamus. D.D. Kline, M.P. Matott. University of Missouri. E583 718.4 Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling in Cardiac Postganglionic Parasympathetic Neurons During the Progression of Heart Failure After Myocardial Infarction. D. Zhang, H. Tu, C. Wang, R. Muelleman, M. Wadman, Y. Li. University of Nebraska Medical Center, First Affiliated Hospital of Xi’an Jiaotong University, People’s Republic of China. E584 718.5 Small-Conductance Ca2+-Activated K+ (SK) Channels Regulate Pre-Sympathetic Neurons in the Hypothalamic Paraventricular Nucleus (PVN) and Parasympathetic Cardiomotor Neurons (CMN) in the Nucleus Ambiguus (NA): Pathological Changes. Z. Cheng, M. Lin, G.M. Toney, Q. Chen. College of Medicine, University of Central Florida, University of Texas Health Science Center at San Antonio and Michigan Technological University. E585 718.6 Inflammation and Impaired α2-Adrenergic Receptor-Mediated Inhibition of Ca2+ Channels Contribute to Hypertension in DOCA-Salt but Not Obese Dahl SS Rats. R.K. Mui, R.N. Fernandes, H.G. Garver, G.D. Fink, H. Xu, J.J. Galligan. Michigan State University. E586 718.7 Noisy Timing of Nicotinic Synaptic Activity Promotes Amplification in Sympathetic Ganglia. J.P. Horn, P.H. Kullmann. University of Pittsburgh. E587 718.8 The Role of the Mechanosensitive Renal Sensory Afferent Nerve Sympathoinhibitory Reno-Renal Reflex in Sympathetic Outflow, Natriuresis, and Blood Pressure Regulation. A. Frame, R. Wainford. Boston University.

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PHYSIOLOGY SUNDAY E588 718.9 GABA and Glycine: Fine Tuning for Inhibitory Control of Brainstem RVLM Neurons. H. Gao, A. Derbenev. Tulane University. E589 718.10 High Salt Intake Induces Sympathetic Activation in Dahl Salt-Sensitive Rats Through Activation of Orexin-TNF Signaling in the Hypothalamic Paraventricular Nucleus (PVN). E. Jiang, M. Huber, Y. Fan, F. Zhu, Q. Chen, Z. Shan. Michigan Technological University, Institute of Public Hygiene, People’s Republic of China. E590 718.11 Maternal Treatment of Renovascular Hypertensive Rats with Hydrogen Sulfide Inhibited Hypertension in Offspring. Y. Wu, Q. Guo, X. Feng, H. Xue. Hebei Medical University, People’s Republic of China.

719. SCHOLANDER POSTER SESSION Poster (Sponsored by: APS Comparative and Evolutionary Physiology) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F1 719.1 Involvement of Serotonergic Neurons in the Ventilatory Response to Hypercapnia in Birds (Chicken, Gallus gallus). K.M. Santos, S.B. Abreu, G.M. Garcia, K.C. Bícego, L.H. Gargaglioni, G.S. da Silva. Sao Paulo State University UNESP-FCAV, Brazil. F2 719.2 Diving Mice vs. Torpid Mice: A Comparison of Cardiovascular Regulation. E.M. Hult, M.J. Bingaman, S.J. Swoap. Williams College. F3 719.3 Insulin Resistance in Horses Varies Throughout the Year and Among Breeds. C.N. Moffatt, Z.W. Paquin, A. Guild, K.M. Johnson. Beloit College and Elkhorn Veterinary Clinic. F4 719.4 Autonomic Control of Thermogenic Capacity Is Optimized in Deer Mice Native to High or Low Altitudes. O.H. Wearing, K.B. Tate, G.R. Scott. McMaster University, Canada and Truman State University. F5 719.5 Expression and Function of an Animal MEP/ Amt Ammonia Transporterm, AeAmt2 in the Larvae of the Mosquito, Aedes aegypti. A.C. Durant, A. Donini. York University, Canada. F6 719.6 Antibodies Against Sodium-Dependent Cation Chloride Cotransporters in the Yellow Fever Mosquito Aedes aegypti. K.C. Viel, A.C. DeBrosse, G.F. Riley, P.M. Piermarini, C.M. Gillen. Kenyon College and The Ohio State University. F7 719.7 Do Ion-Motive Pumps Contribute to ColdAcclimation in Drosophila? G. Yerushalmi, H. MacMillan, A. Donini. York University, Canada. F8 719.8 Temperature Effect on Cardiorespiratory Responses and Autonomic Modulation of Heart Rate in Premetamorphic Bullfrog Tadpoles, Lithobates catesbeianus. L.S. Longhini, L.A. Zena, G.S. da Silva, K.C. Bícego, L.H. Gargaglioni. Sao Paulo State University, Brazil. F9 719.9 Temperature-Induced Changes to Aquaporin Localization in the Freeze-Tolerant Cope’s Gray Treefrog. B. Stogsdill, J. Frisbie, C. Krane, D. Goldstein. Wright State, Wright State University and University of Dayton. F10 719.10 Neuromuscular Inactivity of the Respiratory Control System During Overwintering in Bullfrogs, Lithobates catesbeianus. J.M. Santin, L. Hartzler. Wright State University.

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F11 719.11 RNA-Seq Analysis of the Effects of ColdAcclimation and Freezing on the Hepatic Transcriptome in the Freeze-Tolerant Cope’s Gray Treefrog, Hyla chrysoscelis. M.F. do Amaral, J. Frisbie, D.L. Goldstein, C. Krane. University of Dayton and Wright State University. F12 719.12 Salinity-Dependent Expression of ncc-like 2 in the Gill and Opercular Epithelium of Euryhaline Killifish. J. Doud, C. Popovski, E. Ritter, C. Tipsmark, J. Breves. Skidmore College and University of Arkansas. F13 719.13 FishResp: An R-Package for Filtering and Analyzing Raw Data in Aquatic Respirometry. S. Morozov, S.R. McCairns, J. Merilä. University of Helsinki, Finland and Institut National de la Recherche Agronomique (INRA), France. F14 719.14 Effect of Cortisol on Growth and Gene Expression of insulin-like growth-factor binding proteins (igfbps) In Atlantic Salmon Parr. R. Springer-Miller, D. Chenoweth, A. Paskavitz, A. Regish, S. McCormick, J. Breves. Skidmore College, USGS and Conte Anadromous Fish Research Center. F15 719.15 Role of the Protein Kinase G in the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Marine Invertebrate Aplysia. R. Chatterji, M. Wainwright, R. Mozzachiodi. Texas A&M University-Corpus Christi. F16 719.16 A Paradigm Shift: Benefits of Carbon Monoxide (CO) in Hypoxia-Adapted Species. M.S. Tift, P. Jordan, T. Lueker, P. Cabrales, T. Simonson, E. Heinrich, F. Villafuerte, J. Meir, D.E. Crocker, B. Moore, J. St. Leger, P.J. Ponganis. Scripps Institution of Oceanography, University of California, San Diego, Universidad Peruana Cayetano Heredia, NASA, Sonoma State University and SeaWorld. F17 719.17 Physiological Plasticity and Tolerance of Fundulid Killifish Species to Aquatic Hypoxia. R. Hoffman, B. Borowiec, G. Scott, C. Adams, F. Galvez. Louisiana State University and McMaster University, Canada. F18 719.18 Use of mTOR as a Potential Molecular Marker to Investigate the Development of Obesity in Non-Model Fish Species. R. Spainhour, J. Ball, Y. Kobayashi. Fort Hays State University. F19 719.19 Bicarbonate-Stimulated Soluble Adenylyl Cyclase Is an Acid-Base Sensor Present in the Cell Cytoplasm and Nucleus of Elasmobranch Fishes. J.N. Roa, M. Tresguerres. Scripps Institution of Oceanography.

720. NCAR YOUNG INVESTIGATORS AWARD POSTERS Poster (Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F20 720.1 Brief Exposure to Intermittent Hypoxia Prolongs QTc in Human Subjects, Which Is Abrogated with AT1a Receptor Blockade. N. Jouett, K. Bysani, D. Cooley, M. Cutler, P. Raven, M. Smith. University of North Texas Health Science Center, Texas College of Osteopathic Medicine and Intermountain Healthcare.

SUNDAY PHYSIOLOGY F21 720.2 Effect of Upper Body Position on Arterial Stiffness: Influence of Hydrostatic Pressure and Autonomic Function. E.C. Schroeder, T. Hilgenkamp, A.J. Rosenberg, D.W. White, T. Baynard, B. Fernhall. University of Illinois at Chicago, Erasmus MC University Medical Center Rotterdam, Netherlands and University of Houston-Victoria. F22 720.3 OVLT Neuron Responses to Hypertonic NaCl and Mannitol Differ: Implications for Neural Regulation of Blood Pressure by NaCl. B.J. Kinsman, K.N. Browning, S.D. Stocker. Penn State College of Medicine and University of Pittsburgh. F23 720.4 Black Adults Display Reduced Sympathetic Reactivity to Mental Stress Compared to Non-Hispanic White Adults. I.T. Fonkoue, C.E. Schwartz, B.M. Gervais, J.R. Carter. Michigan Technological University. F24 720.5 Reciprocal Inhibitory Integration and Respiratory Modulation of Arterial Chemoreceptor and Baroreceptor Inputs to Nucleus Tractus Solitarii. D.J. A. Moraes, M.P. da Silva, B.H. Machado, J.F. Paton. School of Medicne of Ribeirão Preto/USP, Brazil and University of Bristol, United Kingdom. F25 720.6 Renal Denervation Lowers Mean Arterial Pressure in Obese Female Schlager Mice but Adversely Affects Glucose Metabolism. N. Asirvatham-Jeyaraj, C.T. Banek, M.M. Gauthier, R. Han, M. Razzoli, A. Bartolomucci, A. Panoskaltsis-Mortari, J.W. Osborn. University of Minnesota. F26 720.7 Renal Pelvic Sensory Nerve Distribution Varies in Rat and Pig. J.L. Perry, N. Hoffman-Schepers, J. Syed, S. Siddiqui, J. Long, M. Knuepfer. Saint Louis University.

721. MICRORNAS IN HEALTH AND DISEASE Poster (Sponsored by: APS Cell and Molecular Physiology Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F27 721.1 Expression of Skeletal Muscle Mirna Are Unaltered During 14 Days of Bed Rest but Decrease Following 7 Days of Reloading in Middle-Aged Adults. E.J. ArentsonLantz, S. Lamon, C.S. Fry, K.L. English, D. PaddonJones. University of Texas Medical Branch and Deakin University, Australia. F28 721.2 miRNA-Mediated Regulation of Insulin Sensitivity in Skeletal Muscle Cells. J. Petrocelli, C. Beach, J.S. Marino. University of North Carolina, Charlotte. F29 721.3 Pathologic Role of microRNA-365 in the Heart. N. Valkov, T. Kim, M. Liu, J. Moeller, M. King, J. O-Uchi, Q. Chen, B. Choi, P. Zhang. Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Department of Orthopaedics and Rhode Island Hospital and Alpert Medical School of Brown University. F30 721.4 Spiny Mouse Is Protected from Ischemia Induced Cardiac Injury: Leading Role of microRNAs. Y. Qi, R. Goel, A.S. Mandloi, R. Vohra, G. Walter, Y.F. Joshua, T. Gu, M.J. Katovich, J.M. Aranda, M. Maden, M.K. Raizada, C.J. Pepine. University of Florida. F31 721.5 Myocardial Infarction-Induced miRNAEnriched Exosomes Contribute to Nrf2 Dysregulation in Chronic Heart Failure. C. Tian, L. Gao, I.H. Zucker. University of Nebraska Medical Center.

F32 721.6 Subconcussive Head Impact Results in a Unique Circulating Exosomal MicroRNA Signature. C.T. Caban, K. Jackson, C.L. Pinson, F.V. Dos Santos, J.J. Jeka, R.T. Tierney, M.B. Hudson. Temple University. F33 721.7 miR429: Potential Regulator of PAK2 in Inflammatory Monocytes. L.C. Stull, M.A. Amin, B.J. Rabquer. Albion College and University of Michigan. F34 721.8 MicroRNAs in Breast Cancer: Growing Understanding of Their Role in Metastasis and Invasion. H. AlHennawi, A. Bux, T. Khan, F. Yousuf, A. Rayes, S. Kazmi, L. Anwer, A. Nurhussen, M. Shareef, A. Yaqinuddin. Alfaisal University, Saudi Arabia, Mayo Clinic and Mercy St. Vincent Medical Center.

722. GENE EDITING, NON-CODING RNA, AND SYSTEMS BIOLOGY Poster (Sponsored by: APS Physiological Genomics Group) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F35 722.1 A CRISPR/Cas9 Toolbox for the Rapid Generation of Intersectional Dual Recombinase Mouse Lines for Anatomical, Molecular, and Functional Neural Circuit Mapping. J. Sun, R.S. Ray. Baylor College of Medicine. F36 722.2 Gene Editing Rat Resource Center (GERRC): Designer Rats for Heart, Lung and Blood Studies. R. Schilling, M. Gryzbowski, S. Pietrzak, A. Temple, A. Zappa, L. Lazcares, J. Niebuhr, S. Kalloway, J. Foeckler, A. Takizawa, A.M. Geurts, M.R. Dwinell. Medical College of Wisconsin. F37 722.3 Kidney-Specific Conditional Knockout of Klotho Gene Impairs Natriuresis and Causes Hypertension by Upregulating Epithelial Sodium Channel Alpha. Q. Ali, Y. Lin, S. Wang, K. Chen, J. Chen, Z. Sun. University of Oklahoma HSC. F38 722.4 The Relationship of miR-21-5p and PPARα in CKD-Related NAFLD and Dyslipidemia. V.L. Nasci, S. Miller, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. F39 722.5 Loss of miR-146b-5p Exacerbates Pathological Left-Ventricular Remodeling in a Rat Model of CKD. M. Paterson, S. Chuppa, A.J. Kriegel. Medical College of Wisconsin. F40 722.6 Selection and Characterization of Novel of RNA Aptamer Recognizing Homocysteine, Which Ameliorates Oxidative Stress in Mouse Brain Endothelial (bEND3) Cells. J. Bala, J. Behera, K. Kelly, N. Tyagi. Univerisity of Louisville. F41 722.7 Dynamic Bayesian Graphical Modeling to Predict Regulatory Networks in Hypertensive Rats. A. Dayton, K. Ahn, P. Liu, P. Laud, F. Stingo, M. Vannucci, J.D. Bukowy, M. Liang, A.W. Cowley Jr. Medical College of Wisconsin, MD Anderson Cancer Center and Rice University. F42 722.8 Modeling of Calcium-Induced Swelling in Spatially Divergent Populations of Cardiac Mitochondria. X.R. Chapa, V. Makarov, S. Javadov. UPR Medical Science Campus and UPR Rio Piedras Campus. F43 722.9 Discovering Interactions and Connections with Bioinformatics Tools at RGD. M. Shimoyama, S. Laulederkind, J. De Pons, M. Tutaj, J. Thota, O. Ghiasvand, V. Petri, J.R. Smith, G.T. Hayman, S. Wang, M. Dwinell. Marquette University and Medical College of Wisconsin and Medical College of Wisconsin.

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PHYSIOLOGY SUNDAY F44 722.10 Simulating Selected Human Hormonal Pathways During a 24-Hour Period and Its Implications for Aging Research. S.A. Garan, G. Efe, K. Cheung, M.A. Khurramb, R. White, J.A. Yukich, G.A. Brooks. UC Berkeley. F45 722.11 A Thermodynamically Constrained Mechanistic Mathematical Model for the Kinetics of NADPH Oxidase Assembly, Activation and ROS Production. N. Tomar, V.R. Pannala, C. Yang, A.W. Cowley, R.K. Dash. Medical College of Wisconsin. F46 722.12 Genelab: Multi-Omics Investigation of Rodent Research-1 Biobanked Tissues. K. Chakravarty, S. Lai, V. Boyko, D. Berrios, H. Fogle, S. Dueck, L. Timucin, J. Galazka, S. Reinsch, O. Stotzky, M. Skidmore. NASA/ Logyx LLC, NASA/kbrWyle, NASA/Bionetics, NASA/University Affiliated Research Center/University of California Santa Cruz and NASA Ames Research Center. F47 722.13 Development of Tools for RNA Interference (RNAi) of the Engrailed Gene in Daphnia magna. D. Singer, M. Beckman. Augsburg College. F48 722.14 Comprehensive Coverage of Rat Models for Human Diseases at the Rat Genome Database. S. Wang, S.J. Laulederkind, J.R. Smith, G.T. Hayman, V. Petri, M. Dwinell, M. Shimoyama. Medical College of Wisconsin.

723. REPRODUCTION, SEX HORMONES, AND GESTATIONAL BIOLOGY

F54 723.6 Effects of Culture Time, Fetal Bovine Serum, Progesterone, Testosterone and Estradiol on Alkaline Phosphatase Activity, Extracellular Matrix Mineralization and Osteoblast Viability. J.E. Lemos, L.F. Brancaglião, A.L. Bonfá, N.F. Rocha, V.M. Gonçalves, L.H. Montrezor. University of Araraquara—UNIARA, Brazil. F55 723.7 Reversible Azoospermia After Long Term Sustained Delivery of DHT. H.A. Benghuzzi. University of Mississippi Medical Center. F56 723.8 Prenatal Food Restriction Causes Adaptive Changes in the Metabolic Regulation of Reproductive Physiology. E.M. Rhinehart. Susquehanna University. F57 723.9 Effect of Perinatal Blockade of Androgen Receptors on Estrogen Receptor Levels in Specific Brain Regions and Spatial Working Memory in Male Rats. R. Hershkowitz, B. Shah, P.A. Nehrt, A. Sanchez, T. Secor, B. Starr, S. Toennies, G. Taylor, C. Gopalan. Southern Illinois University Edwardsville, St. Louis College of Pharmacy and University of Missouri St. Louis. F58 723.10 Letrozole and/or Fructose Induced-Polycystic Ovarian Syndrome in Animal Model. C.O. Akintayo, J.D. Anjola. Afe Babalola University, Nigeria.

724. AUTONOMIC AND RESPIRATORY INTERACTIONS Poster

Poster (Sponsored by: APS Endocrinology and Metabolism Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F49 723.1 Brain Inflammation and Oxidative Stress in the Developmental Programming of Metabolic Syndrome in Adult Offspring to Maternal Nutrition Insult. J.Y. Chan, Y. Chao. Kaohsiung Chang Gung Memorial Hospital, Taiwan. F50 723.2 Fetal Brain Sparing in a Mouse Model of Chronic Maternal Hypoxia. L.S. Cahill, Y. Zhou, J. Hoggarth, M. Seed, C.K. Macgowan, J.G. Sled. Mouse Imaging Centre, The Hospital for Sick Children, Canada, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, Canada, Department of Medical Biophysics, University of Toronto, Canada, Physiology & Experimental Medicine and The Hospital for Sick Children, Canada. F51 723.3 Duality of Early Life Maternal Separation Effects on Offspring Initial Development and Maternal Neuronal Activation. D.R. Fóscolo, F.S. Machado, C.C. Coimbra. Universidade Federal de Minas Gerais (UFMG), Brazil. F52 723.4 Preterm Birth Is Associated with a Decrease in Cervicovaginal L. iners During Second Trimester in Mexican Women. P. Rodriguez-Martin, B. PalaciosGonzalez, F. Vadillo-Ortega. Instituto Nacional de Medicina Genomica, Mexico. F53 723.5 Feed Restriction and IGF-1 Affect the Oocyte Maturation in Matrinxa˜ Brycon amazonicus. L.H. Montrezor, E.C. Urbinati. University of Araraquara—UNIARA, Brazil and Univ. Estadual Paulista—UNESP, Brazil.

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(Sponsored by: APS Neural Control and Autonomic Regulation Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F59 724.1 Firing Properties of Pre-Inspiratory Neurons Are Altered in Female Rats Exposed to Chronic Intermittent Hypoxia. G.M. Souza, M.R. Amorim, D.J. Moraes, B.H. Machado. University of Sao Paulo, Brazil. F60 724.2 Effects of Deep Controlled Breathing on Heart Rate Variability in Young Adults. D. Grigorieva, D. Dimitriev, E. Saperova. Chuvash State Pedagogical University, Russian Federation. F61 724.3 Ventral Medullary Inspiratory Neurons Recordings in Rats Submitted to Sino-Aortic Denervation. M.R. Amorim, G.M. Souza, L.G. Bonagamba, B.H. Machado. School of Medicine of Ribeirão Preto/USP, Brazil. F62 724.4 Effects of Lipopolysaccharide Injection on in Vivo Breathing Pattern in Developing Rats. R.L. Johnson, S. Murray, C.G. Wilson. Loma Linda University. F63 724.5 Six Weeks Inspiratory Muscle Strength Training Lowers Blood Pressure but Does Not Affect Baroreflex Sensitivity or Cardiac Output in Active Young Adults. C.M. DeLucia, R.M. De Asis, E.F. Bailey. The University of Arizona. F64 724.6 A Cellular Mechanism of Leptin Mediated Responses in Mouse NTS Neurons. J. Do, A. Kowal, L. Floreani, D.R. McCrimmon, M. Martina. Northwestern University and International School for Advanced Studies, Italy. F65 724.7 The Vagus Nerve in Development of Lung Tumor. J. Liu, N. Song, J. Guardiola, J. Yu. University of Louisville and Robley Rex VA Med Center. F66 724.8 Improvement in Lower Urinary Tract Function Following a Single Bout of Acute Intermittent Hypoxia in Rats with Chronic Spinal Cord Injury. W.F. Collins, N.P. Phagu, M. Catege, I.C. Solomon. Stony Brook University.

SUNDAY PHYSIOLOGY

725. AIRWAY EPITHELIUM IN HEALTH AND DISEASE Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F67 725.1 Multipotent Myoepithelial Progenitor Cells Are Born Early During Airway Submucosal Gland Development. P. Anderson, T. Lynch, J. Engelhardt. University of Iowa. F68 725.2 Effects of Perinatal Nicotine Exposure on Cholinergic Signaling in the Airway Epithelium. N. Borrero, R. Fregosi, S. Boitano. University of Arizona. F69 725.3 Reducing Allergic Asthma Inflammation and Airway Hyperresponsiveness via a Novel Protease-Activated Receptor-2 Antagonist. C.M. Rivas, M.K. Lovett, T. Neenan, M. Yee, K.A. DeFea, M. Daines, J. Vagner, S.A. Boitano. University of Arizona, University of California at Riverside. F70 725.4 Sodium-Coupled Neutral Amino Acid Transporter SNAT2 Counteracts Edema Formation and Reduces Autophagy and Er Stress in Acute Lung Injury. S. Weidenfeld, C.J. Chupin, S. Rozowsky, W.M. Kuebler. Keenan Research Centre for Biomedical Science, St. Michael´s Hospital, Canada, Charité-Berlin, Germany and University of Toronto, Canada. F71 725.5 Evidence for ACE-2 Ubiquitination and Proteasomal Processing in Lung Epithelium. A. Abdul-Hafez, J. Markey, B. Uhal. Michigan State University. F72 725.6 Utility of Abbreviated Exposure Time in Mice— Contribution to Understanding Pathogenesis of Cigarette Smoke Induced Lung Disease. M.R. Wolfson, S.T. Baker, Y. Tian, K. Bahmed, B. Kosmider, M.M. Marcinkiewicz, J. Wu. Lewis Katz School of Medicine at Temple University.

726. AIRWAY RESPONSIVENESS AND SMOOTH MUSCLE CELL BIOLOGY

F77 726.5 Novel Inflammatory Mechanisms in the Regulation of Airway Hyperresponsiveness: Regulation of Airway Smooth Muscle Kv7 Channel Expression by Rest. L.I. Brueggemann, C. Zhang, P.P. Kakad, L.L. Cribbs, K.L. Byron. Edward Hines Jr. VA Hospital and Loyola University Chicago. F78 726.6 Regulation of Endogenous Kv7 Potassium Channels by Histamine in Primary Cultured Human Airway Smooth Muscle Cells. J.M. Haick, L.I. Brueggemann, J.L. Schwartz, K.L. Byron. Loyola University Chicago and Edward Hines Jr. VA Hospital. F79 726.7 Reflex Bronchoconstriction Evoked by Inhaled Nicotine Aerosol in Guinea Pigs: Role of the Nicotinic Acetylcholine Receptor. R. Lin, M. Khosravi, F. Xu, L. Lee. University of Kentucky and Lovelace Respiratory Research Institute. F80 726.8 Resveratrol Protects Against HyperoxiaInduced Airway Hyperreactivity in Neonatal Rats. R.B. Sopi, S. Reçica, A. Lajçi, I. Kryeziu, Q. Thaçi, I.A. Dreshaj, M. Basholli. University of Prishtina, Faculty of Medicine, Kosovo, University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo, Case Western Reserve University and School of Medicine. F81 726.9 Quercetin Reverses the Enhanced Contractile Responses of Tracheal Smooth Muscle of Neonatal Rats Exposed to Hyperoxia. I. Kryeziu, Q. Thaçi, S. Reçica, F. Kurshumliu, D. Vela, M. Mladenov, M. Basholli, R.B. Sopi. University of Prishtina, Faculty of Medicine, Kosovo, University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo and Ss.Cyril and Methodius University—Faculty of Mathematics and Natural Sciences, Former Yugoslav Republic of Macedonia. F82 726.10 Role of PGE2-EP1/EP3 Receptor Signaling on Hyperoxia-Induced Airway Hyperreactivity in Neonatal Rats. Q. Thaçi, A. Cenaj, R.B. Sopi. University of Prishtina, Faculty of Mathematics and Natural Sciences, Kosovo, University of Prishtina and Faculty of Medicine, Kosovo.

727. CONTROL OF BREATHING: DEVELOPMENT

Poster

Poster

(Sponsored by: APS Respiration Section)

(Sponsored by: APS Respiration Section)

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Sun. 9:00 am—McCormick Place Convention Center, Hall F

Presentation time: 12:45 pm–3:00 pm

Presentation time: 12:45 pm–3:00 pm

F73 726.1 Sex Differences and Role of Sex Hormones in the Expression of Inflammatory Mediators and Lung Function in Response to Ozone. N. Fuentes, N. Cabello, M. Nicoleau, P. Silveyra. Penn State College of Medicine. F74 726.2 Modulation of the Lung Inflammatory Response to Ozone by the Estrous Cycle. P. Silveyra, N. Cabello, S. DiAngelo. Penn State College of Medicine. F75 726.3 Activation of Bitter Taste Receptors Has Distinct Modulatory Effects on Different Lung Afferent Signaling in Rats. Q. Gu, C. Gilbert, H. McLaurin. Mercer University School of Medicine. F76 726.4 TNFα Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells. J.Q. Yap, P. Delmotte, G.C. Sieck. Johns Hopkins University and Mayo Clinic.

F83 727.1 Impact of Gestational Chronic Intermittent Hypoxia and Hypertension on the Serotonergic System and Autoresuscitation in the Developmental Rat. D. Harvey, A. Carrillo Leal, A. Li. Dartmouth College and Geisel School of Medicine at Dartmouth. F84 727.2 Intermittent Hypoxia During Gestation Disrupts Respiratory Rhythm and Neuroplasticity in Newborn Rat Brainstem-Spinal Cord Preparations in Vitro. S.M. Johnson, J. Watters, K. Randhawa. University of Wisconsin-Madison. F85 727.3 Abnormalities in Excitability of Nucleus Tractus Solitarius (nTS) Neurons Following Neonatal Hypoxia Exposure: Implications for Sudden Infant Death Syndrome. C. Mayer, P. MacFarlane. Case Western Reserve University. F86 727.4 Divergent Effects of Myo-Inositol Supplementation on Respiratory Control During Postnatal Development. P. MacFarlane, J. Di Fiore, C. Mayer. Case Western Reserve University and Rainbow Babies & Children’s Hospital.

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PHYSIOLOGY SUNDAY F87 727.5 A Low Cost, Simplified, and Scaleable Pneumotachograph and Face Mask for Neonatal Mouse Respiratory Measurements. J.J. Sun, R. Nanu, R.S. Ray. Baylor College of Medicine and Brandeis University. F88 727.6 Functional Characterization of Developmental Whole Rhombomere Brainstem Populations in Adult Respiratory Physiology. J.J. Sun, R.S. Ray. Baylor College of Medicine. F89 727.7 Sex-Specific Effects of Nuclear and Membrane Progesterone Receptors on Breathing Stability in Newborn Rats. R. Boukari, A. Bairam, V. Joseph. CRIUCPQ— Université Laval, Canada. F90 727.8 Arousal Defects and Apnea in Rat Pups Deficient in Central 5-HT: Interactions with Sleep State. J.O. Young, M. Hodges, K. Cummings. University of Missouri and Medical College of Wisconsin. F91 727.9 Effects of Perinatal Nicotine or Inflammation Exposure on Ventilation in the Developing Rat Model. P.A. Williams, C. Wilson. Loma Linda University and School of Medicine.

728. CONTROL OF BREATHING: INTEGRATED RESPONSES Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F92 728.1 Hypercapnic and Hypoxic Ventilatory Response in Streptozotocin-Model of Alzheimer’s Disease During Wakefulness. M.C. Vicente, K.C. Bícego, D.C. Carrettiero, L.H. Gargaglioni. São Paulo State University, Brazil and Federal University of ABC, Brazil. F93 728.2 The Metaboreflex and the Peripheral Chemoreflex Interact for the Regulation of Ventilation in Patients with Chronic Heart Failure. A.C. Machado, L.C. Vianna, E.A. Gomes, J.A. Teixeira, M.L. Ribeiro, H.V. Junior, A.C. Nobrega, B.M. Silva. Fluminense Federal University, Brazil, Federal University of Latin American Integration, Brazil, University of Brasília, Brazil, Federal Fluminense University, Brazil and Federal University of São Paulo, Brazil. F94 728.3 Ventilatory Response Arising from the Interaction Between the Peripheral Chemoreflex and the Muscle Mechanoreflex in Healthy Humans. T.M. Silva, L.C. Aranda, M.P. Ribeiro, W.M. Medeiros, L. Viana, L.E. Nery, B.M. Silva. Federal University of São Paulo (UNIFESP), Brazil, University of Brasilia, Brazil and Federal University of São Paulo, Brazil. F95 728.4 Changes in Physiological Variables During Slow- and Rapid-Onset Airway Obstruction in Swine. M.B. Blackburn, C. Nawn. United States Army Institute of Surgical Research, University of Texas at San Antonio and Oak Ridge Institute for Science and Education. F96 728.5 Effects of Cervical Spinal Cord Injury on Cough. T. Pitts, A. Huff, C. Greene, K.A. Cheffer, W.A. O’Steen, D.R. Howland. University of Louisville and Robley Rex VA Medical Center. F97 728.6 Cervical C2 Hemisection Acutely Induces Swallow Hyperreflexia. A. Huff, C. Greene, K.A. Cheffer, W.A. O’Steen, D.R. Howland, T. Pitts. University of Louisville and Robley Rex VA Medical Center.

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F98 728.7 Activation of Esophageal Mechanoreceptors Alters the Pharyngeal Phase of Swallow. A. Brown, S.N. King, I. Poliacek, T. Pitts. University of Louisville and Comenius University in Bratislava, Slovakia. F99 728.8 Gasotransmitters in Sleep Apnea. X. ‘Zhang, Y. Peng, C. Irina, Gridina, J. Nanduri, G. Kumar, S. Snyder, P. Nanduri. The University of Chicago and Johns Hopkins University. F100 728.9 Ovalbumin-Induced Airway Inflammation Enhances Hypoxic Ventilatory Response in Rats. O. Broytman, J. Brinkman, D. Pegelow, B. Morgan, M. Teodorescu. Univ of Wisconsin. F101 728.10 The Effects of Five Clinically Relevant Narcotic Drugs on the Generation of Spontaneous Augmented (Sigh) Breaths. C.T. Kortes, K. Grzesek, H.J. Bell. Central Michigan University. F102 728.11 A Study of Gender Influence on the Pattern of Cardiorespiratory Response to Transient and Unrelenting Acute Severe Hypoxemia in Adult Rats. N.J. Van Maele, C.J. Hosner, H.J. Bell. Central Michigan University. F103 728.12 Optogenetic Activation of Leptin-Receptor Expressing Neurons in the Region of the Dorsomedial Hypothalamus Increases Respiratory Motor Output in Mice. Z. Chang, A.S. Kowal, G. Sekerkova, K.E. McKenna, M. Martina, D.R. McCrimmon. Northwestern University. F104 728.13 Infrared Laser Light Elicits Cardiorespiratory Responses When Applied to the Nucleus Tractus Solitarius in the in Situ Rat Brainstem Preparation. G. Kola, T.E. Dick, M. Dutschmann, H. Chiel, M. Jenkins, S.J. Lewis. Case Western Reserve University and Howard Florey Institute of Neuroscience and Mental Health, Australia. F105 728.14 Basal Ventilatory Activity in Conscious Freely Moving Spontaneously Breathing 6-OHDA SNLesioned Parkinson’s Disease Rat Model. R.M. Wadolowski, S.B. Wadolowski, W.F. Collins III, I.C. Solomon. Stony Brook University. F106 728.15 Respiratory Control in a Rat Model of Alzheimer’s Disease (TgF344-AD). K.H. Murphy, D.P. Burns, K. Barry-Murphy, M.G. Rae, K.D. O’Halloran, E.F. Lucking. University College Cork, Ireland.

729. RHYTHM GENERATION Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F107 729.1 In Vivo Studies of Brainstem Neurons with Respiratory Rhythm Activity in a Rat Model of Rett Syndrome. Y. Wu, N. Cui, H. Xing, W. Zhong, C.M. Johnson, C. Jiang. Georgia State University. F108 729.2 The Norepinephrine-Dependent “Postinspiratory Complex” Is Not an Autonomous Generator of the Postinspiratory Rhythm. C. Poon, G. Song. Massachusetts Institute of Technology. F109 729.3 Eupnea, Tachypnea, and Autoresuscitation in a Closed-Loop Respiratory Control Model. C.O. Diekman, C.G. Wilson, P.J. Thomas. New Jersey Institute of Technology, Loma Linda University and Case Western Reserve University.

SUNDAY PHYSIOLOGY F110 729.4 Phasic Inhibition Differentially Modulates Synaptic Dynamics Among Excitatory PreBötzinger Complex Populations to Promote Rapid Breathing in Vivo. N.A. Baertsch, T. Dashevskiy, H.C. Baertsch, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F111 729.5 The Differential Effect of Systemic Inflammation and Chronic Intermittent Hypoxia on the Respiratory Networks Generating Inspiration and Postinspiration. I.M. Agosto, S. Ramirez, A.J. Garcia III, J. Ramirez. Seattle Children’s Research Institute and University of Chicago. F112 729.6 Modulation of KCNQ Channels Is a Potential Mechanism for Controlling Inspiratory Burst Duration. A.L. Revill, A. Katzell, G.D. Funk. University of Alberta, Canada. F113 729.7 Triple Oscillator Hypothesis: Three Excitatory Rhythm Generating Networks Control the Three Phases of Breathing. T.M. Anderson, A.J. Garcia III, N.A. Baertsch, J. Pollak, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F114 729.8 Transitioning to Normal Breathing in Pre-Term and Term Pups During the First Hours of Birth. S.C. Ramirez, I.M. Agosto-Marlin, C.V. Smith, J. Ramirez. Seattle Children’s Research Institute and University of Washington. F115 729.9 Isolated Bullfrog Rostral Brainstems Exhibit a DAMGO-Insensitive Lung-Like Episodic Rhythm in the Presence of Bicuculline. M. Reed, K. Iceman, M. Harris, B. Taylor. University of Alaska, Valparaiso University and California State University Long Beach.

730. LUNG BIOMECHANICS, SURFACTANT AND GAS EXCHANGE Poster (Sponsored by: APS Respiration Section) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F116 730.1 Cigarette Smoke Induced Alterations in Bone Microarchitecture: Regional Differences in a Mouse Model. G. Calendo, D.T. Stapor, S.T. Baker, M. Amin, M.F. Barbe, M.R. Wolfson. Lewis Katz School of Medicine at Temple University. F117 730.2 Postural and Perfusion Related Effects on Lobar Deformation Heterogeneity Following Pneumonectomy Assessed by High Resolution Computed Tomography (HRCT). D.M. Dane, N.J. Tustison, C. Yilmaz, A.S. Estrera, J. Gee, C.C. Hsia. University of Texas Southwestern Medical Center, University of Virginia and University of Pennsylvania.

F118 730.3 Effects of Inhaled Erythropoietin on Canine Post-Pneumonectomy Compensatory Lung Growth. D.M. Dane, C. Yilmaz, D. Gyawali, P. Ravikumar, A.S. Estrera, J. Menon, K. Nguyen, N.J. Tustison, J.C. Gee, C.C. Hsia. University of Texas Southwestern Medical Center, University of Texas at Arlington, University of Virginia and University of Pennsylvania. F119 730.4 The Effect of Equilibriative Nucleoside Transporter 1 on Pseudomonas Aeruginosa-Induced Acute Lung Injury. E.D. Chambers, A. Healy, A. Morrison, S. Rounds, Q. Lu. Alpert Medical School of Brown University and Providence VA Medical Center.

731. REGENERATIVE MEDICINE Poster (Sponsored by: Biomedical Engineering Society) Sun. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:45 pm–3:00 pm F120 731.1 Development of a Poly(Lactic Acid) and Fibrin Device for Use in Bone Regenerative Medicine. R.A. Carvalho, V.V. Rocha Júnior, E.J. Silva, E. Trovatti, M.R. Iemma, A.C. Amaral. University of Araraquara, Brazil and University of São Paulo, Brazil. F121 731.2 Isolation and Expansion of “Youthful” Bone Marrow Mesenchymal Stem Cells from Elderly Individuals. T.J. Block, M. Marinkovic, O. Tran, D.D. Dean, X. Chen. StemBioSys and University of Texas Health Science Center at San Antonio. F122 731.3 Bioactive Fibrin Scaffolds for Use in Regenerative Medicine. S.F. Braga, R. Aquino, A. Carvalho, E. Trovatti, M. Iemma, A.C. Amaral. University of Araraquara, Brazil and University of São Paulo, Brazil. F123 731.4 The Growth and Differentiation Capacity of Porcine Renal Papilla Progenitor Cells Decline with Passaging. D.M. Burmeister, M.K. McIntyre, B.I. Gomez, R. Mongomery, M.A. Dubick. United States Army Institute of Surgical Research. F124 731.5 Angiotensin-(1-7) Treatment Aids in the Recovery of Skeletal Muscle Function After Acute Injury in Rats. T. Criswell, Y. Zhou, B. Yoseph, T. Criswell. Wake Forest Institute for Regenerative Medicine.

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MONDAY, APRIL 24 Anatomy 732. ANATOMY EDUCATION: FACTORS AFFECTING STUDENT PERFORMANCE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E1 732.1 Interprofessional Education in Anatomy: Using Q Methodology to Determine Student Perceptions. C. Mackinnon, N. Akhtar-Danesh, A. Palombella, B. Wainman. McMaster University, Canada. E2 732.2 First Year Medical Students’ Perceptions of Professionalism. E.M. Encisco, A.C. Edmondson, C.A. Nichols. Medical College of Georgia at Augusta University. E3 732.3 Comparison of Academic Performance Within the First Year of Medical School with Performance on a National Board of Medical Examiners (NBME) Comprehensive Exam. W. Yang, C.A. Nichols, A.C. Edmondson. Medical College of Georgia at Augusta University. E4 732.4 Introductory Anatomy Laboratory Teaching, Correlations Between Contact Hours and Student Success. A.J. Oh, L. Georger, E.M. Rokitka, J. Holz, N.R. Olivieri, F. Stephen, M.P. Olivieri. D’Youville College. E5 732.5 The Effect of Retrieval Practice After Sleep on Student Learning. C. Perry, R. Easteal. Queen’s University, Canada. E6 732.6 Student Perception of the Value of Previous Anatomy Coursework on Medical Gross Anatomy. E. Robertson, K. Thompson, A. Notebaert. University of Mississippi Medical Center and Millsaps College. E7 732.7 Characteristics of a Good Basic Science Teacher as Perceived by Medical Students. I. Hajj Hussein, T. Wunderlich, S. Loftus, R. Wedemeyer. OUWB School of Medicine. E8 732.8 Previous Learning Experiences in the Anatomical Sciences. M. Taylor. Indiana University. E9 732.9 Influence of Learning Paradigms on the Retention of Anatomical Knowledge in Medical Students. M. Ahmed, S. Dykowski, T. Tooley, T. Helland, M. Barremkala. Oakland University William Beaumont School of Medicine. E10 732.10 Student Performance in and Perception of Gross Anatomy in Varied Curricular Material Organization in Multiple Cohorts. K.L. Thompson. Mercer University SOM. E11 732.11 Superficial Versus Deep Learning in a Professional Veterinary Anatomy Curriculum. M.A. McNulty, H.A. Richbourg. Louisiana State University School of Veterinary Medicine and Indiana University School of Medicine. E12 732.12 Correlation of Brief Cope and Academic Performance in First Year PA and Dental Students During Human Structure Course. A.S. Thiessen, N. Halliday. University of Oklahoma and University of Oklahoma Health Sciences Center.

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E13 732.13 Student Perceived Difficulties in Learning Organ Systems in an Undergraduate Human Anatomy Course. J. Shaffer, R. Lieu, A. Gutierrez. University of California at Irvine. E14 732.14 Is Anatomy Important for Speech Language Pathology (SLP) Undergraduate Students? M.D. Barros, V.A. Silva, B.M. Liquidato. Santa Casa de São Paulo School of Medical Sciences, Brazil. E15 732.15 Observational Exercise in the Anatomy Lab and Narrative Reflection Contribute to Professional Identity Formation in Medical Students. G. Sorrentino, W. Rennie, A. Fornari, K. Metzger. Hofstra Northwell School of Medicine and Seton Hall-Hackensack Meridian School of Medicine. E16 732.16 Sink, Swim, or Grab a Lifesaver: First Year Medical Student Perception of Academic Performance and Tutoring in an Anatomy Course. P. Stadem, A.D. Ginsburg, F. Hafferty, N. Lachman, W. Pawlina, N. Langley. Mayo Clinic College of Medicine and Science. E17 732.17 internationalization of Medical Education—A Pilot Study Using a Shared Digital Dissector and Early PeerTo-Peer Student Interaction in American and German Clinical Gross Anatomy Courses. A. Wu, C. Goelkel, C. Chiuzan, J. Duong, H. Kielstein, P. Bernd. Columbia University and Martin-Luther-Universitaet, Germany.

733. ANATOMY EDUCATION: LAB TEACHING STRATEGIES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E18 733.1 Perceptions of Dissection Experience in a Professional Veterinary Curriculum. M.A. McNulty, H.A. Richbourg, M.D. Lazarus. Louisiana State University School of Veterinary Medicine, Indiana University School of Medicine and Monash University, Australia. E19 733.2 Utilizing Medical Students’ Attitudes Toward Whole Body Donation in Developing a Whole Body Donation Program. S. Dykowski, M. Ahmed, T. Tooley, T. Helland, M. Barremkala. Oakland University William Beaumont School of Medicine. E20 733.3 Perception of Body Donation Among African Americans. A. Werede, B. Thompson. Oakland University William Beaumont School of Medicine. E21 733.4 Use and Perceptions of Plastination Among Anatomy Medical Educators in the United States. R. Klaus, D. Royer, J. Corral, M.E. Stabio. University of Colorado Anschutz Medical Campus. E22 733.5 Interactions and Perceptions About the Learning Process of Second Year Medical Students When Using Non-Conventional Anatomical Specimens at a Heart and Coronary Anatomy Practical Class. R.J. Rueda-Esteban, C. Hernández. Universidad de los Andes, Colombia.

MONDAY ANATOMY E23 733.6 Everything Old Is New Again: An Alternate Approach to Human Hip Dissection Inspired by a Classic 19th Century Experiment. A. D’Abarno, M. Singleton. Chicago College of Osteopathic Medicine and Midwestern University. E24 733.7 Dissection Opportunity Affects Student Performance on Gross Anatomy Practical and Lecture Examination Questions. A. Marshall, A.R. Thompson. University of Cincinnati College of Medicine. E25 733.8 The Minute Clinic: Increasing Student Engagement in an Undergraduate Systems-Based Anatomy Course. C.A. Hill, K. Aldridge, C.M. Holliday, K.M. Middleton, C.V. Ward, S.A. Maiolino, M.E. Jorgensen. University of Missouri-Columbia and Rocky Vista University College of Osteopathic Medicine. E26 733.9 The Anatomy Laboratory as a Fulcrum of Basic and Clinical-Science Integration. F. Nausheen, G. Al-Eyd, R. Ettarh, S. Hassan, M. Yakub, R. Suskind, A. Tenore. California University of Science and Medicine and School of Medicine. E27 733.10 Pilot Project: Delivering Ultra-Low Cost Digitally Guided Dissection. T. Frasch, M.L. Korndorffer; MD; FACS. Tulane University. E28 733.11 Navigating Your First Cut: A Hands-Off Animated Guide to the First Year Anatomy Lab. M. Garabedian, Z. Rothman, M. Fejtek, L. Vo, C. Krebs. University of British Columbia, Canada. E29 733.12 The Use of Radiological Imaging to Enhance Gross Anatomical Learning: Thoughts and Practices. S.D. Inglis, A.M. Delbalso, R.P. Dannenhoffer. University at Buffalo.

734. ANATOMY EDUCATION: OUTREACH Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E30 734.1 Contributing to the Future of Diversity in Medicine: A Powerful Outreach Program at the SUNY Downstate College of Medicine. A. Diaz, T. Jones, A.S. Pagano, S. Márquez. SUNY Downstate Medical Center and NYU School of Medicine. E31 734.2 Building Bridges Between Brazil and the US: Anatomical Sciences and Medical Education. D.F. Curcio, J.T. Laitman. Icahn School of Medicine at Mount Sinai and Santa Casa School of Medical Sciences—Sao Paulo, Brazil. E32 734.3 Neuroscience Outreach Education: Establishing Partnerships Between Graduate and Secondary School Programs. B. Puder. Samuel Merritt University. E33 734.4 Anatomical Connections: Linking High Schools to the UVM College of Medicine with Anatomy. S.A. McCarthy, S.P. Flynn, L. Merrill. University of Vermont. E34 734.5 Physiology Understanding Week (PhUn Week), First Time in Kingsville, Texas: The Immune System. R.A. Johnson. Texas A&M University—Kingsville. E35 734.6 PhUn Overview of the Cardiovascular System. R. Williams, M.E. Hernandez-Velez. Texas A&M Kingsville.

E36 734.7 Medical Education Across Borders—Are You GAAAME? J.M. Ziermann, D.F. Curcio. Howard University College of Medicine, Icahn School of Medicine at Mount Sinai— New York and Santa Casa School of Medical Sciences—Sao Paulo, Brazil. E37 734.8 Inside Dinosaurs: A Broader Impacts Program for Research, Teaching and Public Education Through Dinosaur Biology, Physics and Evolution. C.M. Holliday, C.A. Hill, J.L. Davis, L.M. Witmer, K.M. Middleton. University of Missouri, University of Southern Indiana and Ohio University. E38 734.9 Medical School Anatomy/Pathology Workshops for High School Students Enhance Learning, Model Professionalism, and Provide Inspiration for Careers in Medicine. G. Zhang, B.A. Fenderson, J.J. Veloski, M. Livesey, T. Wojdon-Smith. Thomas Jefferson University and Eastern Regional High School. E39 734.10 An Innovative Pedagogical Project to Study the Genital System and Learn About Sexually Transmitted Diseases (STDs) in Brazilian Public High School. T.S. Masuko, L.d. Fragassi, D.T. Conceição, L.D. Souza Santos, T. Andrade Magalhães, M.M. Maron e Silva, L.M. Moraes. UFBA—Federal University of Bahia, Brazil.

735. ANATOMY EDUCATION: CLINICAL SKILLS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E40 735.1 Anterior Components Separation (ACS) by Endoscopic Pathway: Alternative Pathway to Approach the Abdominal Wall. M.D. Barros, S. Roll, R.T. Nishio, R.A. Silva, D.P. Ayres Neto, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E41 735.2 Transoral Thyroidectomy: Anatomical Aspects of an Esthetic Access. M.D. Barros, A.J. Gonçalves, R.T. Nishio, N.K. Kavabata, D.P. Ayres Neto, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E42 735.3 Improving the Use of Pelvic Binding Devices During Pre-Hospital Care Through Application Modules on Advanced Dissection Specimens During Advanced Care Paramedic Labs. A.J. Stubbs, G. Sullivan, L.C. Jadeski. University of Guelph, Canada. E43 735.4 Teaching Model for Reconstruction of the Abdominal Wall via the Separation of Anterior and Posterior Components Technique. M.D. Barros, S. Roll, R.A. Silva, C.J. Mendes. Santa Casa de São Paulo School of Medical Sciences, Brazil. E44 735.5 Effect of Simulation-Based Cerebral Angiography Training on Navigational Error in Novices. O. Zaika. Western University, Canada. E45 735.6 Integrating Clinical Medicine with the Basic Sciences: Musculoskeletal System Cadaver-Based Learning Module for Medical Students. M. Doroudi, A. Majdzadeh, A. Wong, H. Nouraei. UBC, Canada.

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736. ANATOMY EDUCATION: 3D MODELS Poster

Poster

Mon. 9:00 am—McCormick Place Convention Center, Hall F

Mon. 9:00 am—McCormick Place Convention Center, Hall F

Education

Education

Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm

Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm

E46 736.1 To Model or Not to Model Embryonic Heart Development, That Is the Educational Question. B. Blezinski, A. Richardson, L.M. Lee. University of Colorado Denver Anschutz Medical Campus and University of Colorado School of Medicine. E47 736.2 Aortic Automatic Segmentation and 3D Printing for Educational Purpose—A Preliminary Approach. J.D. Coronel, J. Palacio Varona, R.J. Rueda Esteban, P.A. Abelaéz Escalante. Universidad de los Andes, Colombia. E48 736.3 From 3D Brains to 3D PDFs: Creating Virtual 3D Models of Human Brains for Neuroanatomy Classes Through Photogrammetric 3D Scanning. R. Sikes, C. Bernardo, E. Yavetz, J. Chan. Northeastern University. E49 736.4 3D Methods for Medical Education and Clinical Practice. M. Buynak, L.K. Song, D. Dufeau. Marian University College of Osteopathic Medicine. E50 736.5 An Innovative 3 Dimensional Model of Middle Ear. S. Dixit, A. Dixit, S. Ghatak. All India Institute of Medical Sciences and Jodhpur, India. E51 736.6 The Promise of Mixed Reality in Anatomy Education. M. Romaniuk, J. Lamb, J. Mitchell, I. Bayer, B. Wainman. McMaster University, Canada. E52 736.7 Segmenting the Data Stream: Harnessing Contrast-Enhanced Imaging from Widely Available, Anonymized Patient Data to Generate 3-D Training Tools for Clinical Gross Anatomy. J.T. Todd, P.M. Gignac. Oklahoma State University Center for Health Sciences. E53 736.8 Visualization of Cardiac Anatomy: New Approaches for Medical Education. R.M. Whitman, D. Dufeau. Marian University College of Osteopathic Medicine. E54 736.9 Imaging and 3d Reconstruction of Anatomical Specimens as an Alternative to Traditional Learning Models. S.D. Inglis, J.E. Tomaszewski, R.P. Dannenhoffer. University at Buffalo. E55 736.10 3D Printed Models to Visualize Fascial and Peritoneal Layers of the Abdomen in Medical Gross Anatomy. M.E. Orczykowski, A. Zumwalt. Boston University School of Medicine. E56 736.11 Assessing the Use of Paper Musculoskeletal Models in Anatomy and Physiology Classes for Undergraduate Students. S.J. Rehorek, P.G. Falso. Slippery Rock University. E57 736.12 Creation and Evaluation of 3D Sectioned Pig Heart Models to Supplement Cardiac Ultrasound Training for Undergraduate Medical Students. T.A. Harvey, D.F. Royer. University of Colorado Denver Anschutz Medical Campus.

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737. ANATOMY EDUCATION: RADIOLOGY

E58 737.1 Comparing First-Year Medical Students Performance on Radiology and Non-Radiology Components of a Gross Anatomy Course. A.D. Ginsburg, J.A. Knight, C.M. Gibbs, P.S. Stadem, W.B. Hoch, J.A. Harvey, P.W. Eiken, N. Lachman, W. Pawlina. Mayo Clinic School of Medicine, Mayo Clinic and Mayo Clinic College of Medicine and Science. E59 737.2 An Authentic Link to the Clinic: Implementation of an Integrated Anatomy-Radiology Curriculum. K. Darras, J. Reeves, A. Roston, J. Hu, S. Nicolaou, B. Forster, C. Krebs. University of British Columbia, Canada and University of Alberta, Canada. E60 737.3 Radiology Touchscreen Kiosks as a Multi-Modal Replacement for the Viewbox. T. Frasch. Tulane University.

738. ANATOMY EDUCATION: PRESERVATION TECHNIQUES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E61 738.1 The Use of Nigrosin Staining to Increase Brain Slice Contrast for Neuroanatomy Teaching. A.N. Saraco, N. MacPhee, A.K. Ball, B.C. Wainman. McMaster University, Canada. E62 738.2 Improving the Quality of Prosected Limbs in Gross Anatomy by Dissecting Under Water. Y. Gao, A.P. Vitela, A. Ransom, S. Alturkustani, A. Reynolds, C. Miller, L. Nieto, R. Ettarh. Tulane University School of Medicine and California University of Science and Medicine. E63 738.3 Educational Advantages to the Use of Soft Fixed Cadavers. G. Smith. Saint Louis University School of Medicine. E64 738.4 The Novel Use of Silicone Dielectric Gel for Central Nervous System Encapsulation and Preservation. P. Persino, K. Samonds, D. Olson, M. Jenkins. Chicago Medical School and Northern Illinois University.

MONDAY ANATOMY

739. ANATOMY EDUCATION: SPATIAL ABILITIES Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Education Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E65 739.1 Spatial Abilities and Effect of Working Memory on Drawings of Objects from Haptic Perception. J. Langlois, Y. Dagenais, M. Martin, R. Lemieux, M. Lecourtois, J. Bernick, C. Bellemare, E. Yetisir, G. Bergeron, S. Hamstra, G. Wells. CIUSSS de l’Estrie—CHUS, Canada, Université de Sherbrooke, Canada and University of Ottawa, Canada. E66 739.2 Evidence That Studying Histology Improves Students’ Spatial Ability. N.A. Schmalz, K.W. Condon, J.J. Brokaw. Indiana University School of Medicine. E67 739.3 The Creation and Evaluation of a Novel Anatomical Mental Rotation Test for Medical Education Research. M.E. Keeler, M.E. Stabio, D.F. Royer. University of Colorado Anschutz Medical Campus and University of Colorado School of Medicine. E68 739.4 How Learning Methods in Anatomy Allow a Boost of Visuospatial Abilities for Undergraduate Students. V. Defaweux, D. Ernst, A. Dernier, J. Van de Poel, L. Seidel, P. Bonnet. University of Liege, Belgium.

740. CELL BIOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cell Biology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E69 740.1 Widespread Growth Factor Expression in the Reptilian Epidermis Indicates Roles During Homeostasis and Wound Healing. N. Subramaniam, J. Petrik, M. Vickaryous. University of Guelph, Canada. E70 740.2 Characterization of a Non-Canonical Role for Tcf3 in Skin Tumorigenesis. A.T. Ku, H. Nguyen. Baylor College of Medicine. E71 740.3 Cell-Specific Relations Between Vasopressin and Renin-Angiotensin-Aldosterone Systems. Y. Giesecke, T. Giesecke, K. Kawahara, T. Koshimizu, N. Gimber, J. Schmoranzer, S. Bachmann, K. Mutig. CharitéUniversitätsmedizin Berlin, Germany, University of St. Andrews School of Medicine, United Kingdom, Kitasato University School of Medicine, Japan and Jichi Medical University, Japan. E72 740.4 Primary Sertoli Cell Cultures from 30-DayOld Rats Form Cords with a Morphologically Differentiated Phenotype. A. Sriram, H. Huynh, J. Shadarevian, D. Djaksigulova, A. Vogl. University of British Columbia, Canada. E73 740.5 Expression of Prolactin (PRL) in Prostate Gland: Studying Histopathology on Cadaveric Tissue Samples. S. Nomigolzar, N. Khamooshi, L. Sandy, G.M. Nagy. Ross University School of Medicine, Dominica. E74 740.6 The Pattern of VEGF Expression in Avian Renal Development. R.T. McNeil, C.B. Penny. Sefako Makgatho Health Sciences University (SMU) (Formerly called MEDUNSA), Pretoria, South Africa, South Africa and University of the Witwatersrand Medical School, South Africa.

E75 740.7 Immunohistochemical Characterization of Hepatic Progenitor Cell Niche in Liver Fibrosis of Elderly Cadavers. K.M. Mak, S. Chiu. Icahn School of Medicine at Mount Sinai. E76 740.8 Expansion of Hepatic Progenitor Cell Population in Liver Fibrosis of Elderly Cadavers. S. Chiu, K.M. Mak. Icahn School of Medicine at Mount Sinai. E77 740.9 Foetal Intraperitoneal AAV8 Injections as a Valid and Promising Tool to Specifically Target Neuronal Subpopulations Within the Gastrointestinal (GI) Tract. K. Winckelmans, R. Buckinx, S. Waddington, J. Timmermans. University of Antwerp, Belgium and University College London, United Kingdom. E78 740.10 Sexual Dimorphism of Human Vallate Papillae—A Human Cadaveric Study of Normative Morphology. A.A. Rickards, J. Holmes, M.R. Ganoe, K.N. Bliss, M.L. Russell, H.L. Lynch, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E79 740.11 Classification of Vallate Papillae Based upon Morphology and Other Associated Anatomical Features. J. Holmes, A.A. Rickards, M.L. Russell, K.N. Bliss, H.L. Lynch, M.R. Ganoe, M.J. Zdilla, H. Lambert. West Virginia University School of Medicine and West Liberty University. E80 740.12 Analysis of Cellular Responses to Imiquimod in Taste Cells. A.Y. Huang, S.Y. Wu. Southern Illinois University School of Medicine. E81 740.13 Functional and Morphological Characteristics of Efferent Bouton Mitochondria of the Inner Ear. S. Sobkiv, A. Kambalyal, G. Perkins, A. Lysakowski. Univ. of Illinois at Chicago and Univ. of California at San Diego. E82 740.14 Mitochondria Adjacent to Ribbon Synapses in Vestibular Hair Cells Are Not Polarized Toward the Synapse. A. Jayakumar, L. Ghatalah, G. Perkins, A. Lysakowski. University of Illinois at Chicago and University of California at San Diego. E83 740.15 Assessing the Asymmetrical Distribution of Crista Junctions in Tubular Mitochondria Located Adjacent to a Post-Synaptic Density of a Vestibular Hair Cell Ribbon Synapse. S. Vazirian, V. Babu, G. Perkins, A. Lysakowski. University of Illinois at Chicago, Illinois Math and Science Academy, University of California at San Diego. E84 740.16 Mitochondria Near Ribbon Synapses in Inner Ear Hair Cells. L. Ali, A. Jayakumar, G. Perkins, A. Lysakowski. University of Illinois at Chicago and University of California at San Diego. E85 740.17 Energy Output Characteristics of Efferent Bouton Mitochondria of the Inner Ear. A.C. Kambalyal, S. Sobkiv, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California, San Diego. E86 740.18 Structural Analysis of Inner Ear Hair Cell Mitochondria Near the Striated Organelle. J. Lesus, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California, San Diego. E87 740.19 Cristae in Inner Ear Hair Cells Mitochondria Are Polarized Toward Cuticular Plate. K.D. Arias, S.D. Price, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University of California San Diego. E88 740.20 Cristae Align Across Mitochondrial Membranes in Vestibular Hair Cells to Possibly Increase ATP Output. M.H. Patel, G. Perkins, A. Lysakowski. University of Illinois at Chicago, University California San Diego. E89 740.21 Energy Output of Mitochondria Located Near Synaptic Ribbons in Inner Ear Hair Cells. V. Babu, S. Vazirian, G. Perkins, A. Lysakowski. Illinois Math and Science Academy, University of Illinois at Chicago, University of California, San Diego.

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ANATOMY MONDAY E90 740.22 Polyketide Synthase Is Required for Zebrafish Otolith Biomineralization. K. Thiessen, L. Higuchi, K. Kramer. Creighton University School of Medicine. E91 740.23 Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development. K.L. Kramer, C.J. Inserra. Creighton University.

741. CELL BIOLOGY: MEMBRANES AND CYTOSKELETON Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Cell Biology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E92 741.1 Identification and Characterization of Bacterial and Host Factors Involved in Microtubule Disassembly in Epithelial Cells During Edwardsiella Infections. P. Aggarwal, Q. Wang, Q. Liu, K. Leung, J.A. Guttman. Simon Fraser University, Canada, East China University of Science and Technology, People’s Republic of China, and Trinity Western University, Canada. E93 741.2 Palladin Can Compensate for Arp2/3 Complex Defects and Structurally Organizes Actin-Rich Structures Generated during Listeria monocytogenes infections. A.S. Dhanda, A.W. Vogl, C.A. Otey, M.R. Beck, J.A. Guttman. Simon Fraser University, Canada, University of British Columbia, Canada, University of North Carolina and Wichita State University. E94 741.3 The Klebsiella pneumoniae Gene ytfL Triggers Microtubule Disassembly in Lung Epithelial Cells Through KATNA. L1 M.D. Chua, L. Siu, K. Yeh, J.A. Chua. Simon Fraser University, Canada, National Health Research Institutes, Taiwan, Tri-Service General Hospital and National Defense Medical Center, Taiwan. E95 741.4 IP3R, TRPM6 and Homer1 Are Localized to ER-PM Contact Sites at Tubulobulbar Complexes in Rat Testis. A. Adams, A. Vogl. The University of British Columbia, Canada. E96 741.5 IP3R Is Localized to ER-PM Contact Sites at Unique Endocytic Structures Involved in Intercellular Junction Turnover Events Critical to Spermatogenesis. K. Lyon, P. Asghari, D.R. Scriven, E.D. Moore, A. Vogl. University of British Columbia, Canada.

742. DEVELOPMENT AND GROWTH: LIMBS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E97 742.1 Determining the Role of Natural Killer Cells in Immune-Mediated Fetal Growth Restriction in Rats. K. Baines, S. Renaud. The University of Western Ontario, Canada. E98 742.2 The TALLYHO Mouse as a Model of ObesityInduced Linear Growth Acceleration. C.A. Meadows, J. Kim, S. Arthur, G. Ion, H.L. Racine, J.C. Kerby, M.A. Serrat. Marshall University Joan C. Edwards School of Medicine.

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E99 742.3 Lmx1b-Dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation. L.A. Ivey, E. Haro, C.U. Pira, K.C. Oberg. Loma Linda University. E100 742.4 Identification of a Novel Silencer Within an Lmx1b Mediated Cis-Regulatory Module. A.L. Gray, E. Haro, C.D. Spady, C.U. Pira, K.C. Oberg. Loma Linda University. E101 742.5 Analysis of Sp6 and Sp8 Protein-Protein Interactions and DNA Binding During Limb Development. M. Ros, R. Pérez-Gómez, M. Fernández-Guerrero, S. Zunzunegui, S. Bell, J.F. López-Giménez. Instituto Biomedicina y Biotecnologia de Cantabria, Spain, Universidad de Cantabria, Spain and Cincinnati Children’s Hospital Medical Center Cincinnati. E102 742.6 Chondrocyte Columns Are Shorter in the Growth Plate of Collagen XXIV Null Mice. M. Gordon, P. Zhou, R. Hahn, D.R. Gerecke. Rutgers University.

743. DEVELOPMENT AND GROWTH: CRANIOFACIAL Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Developmental Biology/Morphology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E103 743.1 Cadherin-6B Proteolysis Controls the Neural Crest Cell Epithelial-to-Mesenchymal Transition Through Transcriptional Regulation. L. Taneyhill. University of Maryland. E104 743.2 Cell Migration and Palatal Fusion. S. Logan, D. Benson. Texas A&M University College of Dentistry. E105 743.3 In Vivo Inhibition of microRNA (miR) Using a Novel miR Inhibitor System Reveals a Role for miR-17-92 in Palate Elevation and/or Extension. R.J. Ries, W. Yu, S.L. Eliason, H. Cao, B.A. Amendt. University of Iowa Carver College of Medicine and University of Iowa College of Dentistry. E106 743.4 Analysis of Craniofacial Variation in cleft secondary palate-1 Heterozygous and Homozygous Newborn Mice. H. Bennett, R. Moskal, J. Holloway, J. Jones, N. Holton, E. Leslie, B. Bjork. Midwestern University and University of Iowa. E107 743.5 Cleft Palate Case-Derived ARHGAP29 Mutation Causes Lethality and Oral Adhesions in Mice. B.J. Paul, K. Palmer, J.C. Sharp, C.H. Pratt, S.A. Murray, M. Dunnwald. University of Iowa and The Jackson Laboratory. E108 743.6 Gene Expression of Angiogenesis Markers in Mouse Mandibular Condyle During Development. I. Sato, Y. Maeda, Y. Miwa, M. Sunohara. The Nippon Dental University, Japan. E109 743.7 FGF8 Dosage and Tissue Interactions Contribute to Jaw Asymmetry in Disease. J.L. Fish, K. Dolan, R. Green, R.S. Marcucio, B. Hallgrimsson. UMass Lowell, University of Calgary, Canada and UCSF. E110 743.8 A Sox2-Lef-1 Protein Interaction Inhibits Lef-1 Transcriptional Activity and WNT Signaling During Odontogenesis. M.E. Sweat, W. Yu, S. Eliason, B.A. Amendt. University of Iowa, Craniofacial Anomalies Research Center and Carver College of Medicine. E111 743.9 Do Secretory-Stage Ameloblasts Divide? Experimental Evidence. R. Hogg, T. Smith, N. Ward, S. Gografe. Florida Gulf Coast University, Slippery Rock University and Florida Atlantic University.

MONDAY ANATOMY E112 743.10 Pitx2 Controls Dental Stem Cell Proliferation and Differentiation by Regulating Cyclin D2 and Irx1. W. Yu, Z. Sun, S. Eliason, B.A. Amendt. The University of Iowa. E113 743.11 microRNA-26b-5p Targets Lef-1 to Regulate Molar and Incisor Development. S.L. Eliason, M.R. Bustillo, N. Holton, B.A. Amendt. University of Iowa. E114 743.12 Skull and Aerodigestive Tract Growth in Early Postnatal Life: Establishing a Sample. D.F. Curcio, J. Delgado, J.T. Meaike, A. Gupta, K. Zur, K. Shekdar, J.T. Laitman. Icahn School of Medicine at Mount Sinai, Santa Casa School of Medical Sciences—Sao Paulo, Brazil and The Children’s Hospital of Philadelphia. E115 743.13 The Back to Sleep Campaign, Positional Cranial Deformity, and the Foramen Magnum: New Lessons Learned from Old Pachacamac Crania. M.J. Zdilla, A.W. Koons, M.L. Russell, K.N. Bliss, K.R. Mangus. West Liberty University. E116 743.14 Fluorescent Labeling in the Leopard Gecko Resolves Tooth Initiation Patterns in Ovo and Suggests Origins of Post-Hatching Shedding Patterns. T.M. Grieco, K.S. Brink, J.M. Richman. University of British Columbia, Canada.

744. NEUROBIOLOGY: NEURONAL AND SPINAL CORD DEGENERATION, REPAIR AND REGENERATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E117 744.1 Homeostatic Neurogenesis in the Lizard Brain. R.P. McDonald, M.K. Vickaryous. University of Guelph, Canada. E118 744.2 Distribution of Neural/Stem Progenitor Cells in the Brain of the Leopard Gecko (Eublepharis macularius). R.P. McDonald, S.S. Bradley, M.K. Vickaryous. University of Guelph, Canada. E119 744.3 Peripheral Blood Neutrophil Activity Profiles in Dogs with Spinal Cord Injuries: A Longitudinal Analysis. R.L. Russell, C. Welsh, N.D. Jeffery, C.R. Young, G.J. Levine, J.M. Levine. Texas A&M University. E120 744.4 Neuron-Specific Transgene Expression of IMP2 Mediated by Synapsin Promoter-Driven AAV9. D. Park, S. Blizard, S. Austin, J. Harman, S. Haraszti, M. Xu. Philadelphia College of Osteopathic Medicine. E121 744.5 Investigating UBA1 Distribution and Its Relevance to Spinal Muscular Atrophy. A. Maani, H. Shorrock, T. Gillingwater. The University of Edinburgh, United Kingdom. E122 744.6 (Z)-Bisdehydrodoisynolic Acid (BDDA), a Non-Steroidal Uterotrophic and Potentially Neuroprotective Compound in Brain Injury, Induces Proestrus-Like Luteinizing Hormone Secretion and Lordosis Behavior in Ovariectomized Female Rats. R.W. Clough, N.S. Viscomi, L. Arbogast, Y. Hou, W.J. Banz. Southern Illinois University School of Medicine and Southern Illinois University Carbondale. E123 744.7 Trigeminal Neuralgia in Rats with Hypothyroidism: A Morphological Study. O.P. Sobrinho, H.F. Silveira, L.A. Vieira, K.O. Sousa, D.B. Dias, D.V. Gondim, M.L. Vale. Universidade Federal do Ceará, Brazil.

E124 744.8 Changes in the Extracellular Matrix Following Ischemic Stroke in the Rat. M. Patel, A. McClain, A. Meyer, E. Andrews. Midwestern University. E125 744.9 Therapeutic Effects of Long-Term Systemic Adipose-Derived Stem Cell Conditioned Medium in a Mouse Model of Amyotrophic Lateral Sclerosis. C.L. Walker, F.M. Kennedy, C.M. Fry, A.K. Iyer, Y. Du, K. March, K.J. Jones. Indiana University School of Medicine and Roudebush VA Medical Center.

745. NEUROBIOLOGY: BEHAVIOR; NEUROPSYCHIATRIC DISORDERS; DISEASE; AGING Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E126 745.1 DNA Methylation and mRNA Expression in the dmPFC Are Altered After Protracted Withdrawal from Cocaine Self-Administration. K. Ploense, P. Vieira, T. Kippin. UC Santa Barbara. E127 745.2 Expression of Glial Fibrillary Acidic Protein (GFAP) and Histopathological Changes in Brains of Trypanosoma brucei brucei Experimentally Infected Rats. J.N. Alawa, J.S. Maliki, Y. Tanko, C.I. Alawa. Ahmadu Bello University, Nigeria and University of Abuja, Nigeria. E128 745.3 Serum Enkephalin Levels Correlate with EAE Disease Severity. M.D. Ludwig, I.S. Zagon, P.J. McLaughlin. Pennsylvania State University College of Medicine. E129 745.4 Withdrawn. E130 745.5 Amphetamine-Induced Hyperlocomotor Activity in Heterozygous Disc1 Mutant Mice. C. Lai, L. Lee. National Taiwan University, Taiwan. E131 745.6 Different Expression of miRNA in the Elderly with Cognitive Impairment and Control Group in Aluminum Exposed Mining Area. H. Ma, H. Huang, L. Tang, S. Zhou, B. Chen, Y. Ling. Youjiang Medical University for Nationalities, People’s Republic of China. E132 745.7 Cognitive Function in Varsity Football Athletes Is Maintained in the Absence of Concussion. D. BrewerDeluce, T. Wilson, A.M. Owen. Western University, Canada.

746. NEUROBIOLOGY: DEVELOPMENT Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E133 746.1 Vexin (Vxn) Regulates Neurogenesis and Cell Cycle Exit Downstream of Proneural Factors. K. Moore, M. Logan, I. Al Diri, M. Steele, M. Vetter. University of Utah and Oregon Health Sciences University.

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ANATOMY MONDAY E134 746.2 Ronin (Thap11) Is Implicated in a New Cobalamin Deficiency Syndrome Impacting the Central Nervous System. A. Achilleos, X. Tong, R.A. Poché. Baylor College of Medicine. E135 746.3 Morphological and Physiological Characterization of Cortical Subplate Neurons in ForebrainSpecific Ctgf Knockout Mice. Y. Lu, L. Lee. National Taiwan University, Taiwan. E136 746.4 Motor Neuron Scaling and Somatic Growth in Normal and Transgenic Rainbow Trout, Oncorhynchus mykiss. C.W. Anderson, E.T. Feurborn, T.M. Bradley, K.J. Rodnick. Idaho State University and University of Rhode Island.

747. NEUROBIOLOGY: NEUROPROTECTION AND NEUROIMMUNOLOGY Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E137 747.1 ‘Gene Expression Profile Analysis of Immunodeficient Mice After WT or mSOD1 Immunoreconsitution Reveals Differential Motoneuron Death Mechanisms After Facial Nerve Axotomy. D.O. Setter, E.M. Runge, N.D. Schartz, V.M. Sanders, K.J. Jones. Indiana University School of Medicine, Roudebush VAMC and The Ohio State University. E138 747.2 Swine Barn Dust Exposure Activates Microglia Through Induction of Oxidative Stress and the Resultant Neuroinflammation Appears to Involve HMGB1 and RAGE Signaling. N. Massey, S. Puttachary, S. Mahadev-Bhat, D. Shrestha, A.G. Kanthasamy, C. Charavaryamath. Iowa State University. E139 747.3 Effects of Dietary Isoflavones, Age, and Stroke on Estrogen Pathway Activation in Male Rats. M.L. Hart, K. Huber, E.D. Grisley, J.L. Cheatwood. SIU School of Medicine. E140 747.4 Withdrawn.

748. ANATOMY: NEURAL Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: O  dd board # 12:00 pm–1:00 pm Even board # 1:00 pm–2:00 pm E141 748.1 Cutaneous Innervation of the Palmar Aspect of the Hand. M. Hurley, T. Stevens, R. Fracassi, D. Neu, M.P. Olivieri. D’Youville College. E142 748.2 Nerval Danger Zones for Surgical Procedures of the Arm and the Forearm. L. Hirtler, V. Wlodek. Medical University of Vienna, Austria. E143 748.3 Baxter’s Nerve Impingement and Other Neuropathies of the Foot: Implications for Physical Therapy. B.J. Hornick, A.H. Amabile. Thomas Jefferson University.

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E144 748.4 A Study to Determine the Incidence and Examine the Implications of Phrenic Nerve Dysfunction in Cervical Spine Hyper-Flexion/Extension Injury. K.A. Turner, D. Walton, M. Johnson, K. Willmore, T. Wilson. Western University, Canada. E145 748.5 The Ligamentum Flavum Thickens During the Advanced Stages of Hypomobility Induced Lumbar Spinal Osteoarthritis. T. Pulisetty, A.N. Benckendorf, J.A. Merlo, G.D. Cramer, J.W. Little. Saint Louis University School of Medicine and National University of Health Sciences. E146 748.6 The Lumbar Facet Joint Synovial Fold Intimal Surface Length Decreases During the Onset of Cartilage Degeneration Following Spinal Hypomobility. J.M. Allison, J.A. McDowell, J.A. Merlo, G.D. Cramer, J.W. Little. Saint Louis University School of Medicine and National University of Health Sciences. E147 748.7 Identification of the Neurotransmitter Substance P in Sural Nerve of Rats: An Immunohistochemistry Approach. C. Giorgetto, A.B. Simoes, V.S. Fazan. School of Medicine of Ribeirao Preto, Brazil. E148 748.8 Decreases in Relative Cerebellum Volume Are Correlated with Digit Reduction and Limb Loss in Squamates. C.P. Heesy, M.I. Hall, S.A. Ruiz, N.Wells. Midwestern University. E149 748.9 Morphological Comparison of the Pudendal Canal and Its Neurovascular Elements in Human and Domestic Mammals. J.R. Rodriguez-Sosa, M.I. Hall, J.H. Plochocki, S.A. Ruiz, B. Adrian. Arizona College of Osteopathic Medicine, College of Veterinary Medicine, Midwestern University and Arizona College of Osteopathic Medicine Midwestern University. E150 748.10 Neuroanatomical Variants of Clinical Importance in the Population of Ethiopia. A.T. Wirtu, S.A. Geneti, S.T. Haile Georgis, J.M. Gemechu. Addis Ababa University School of Medicine, Ethiopia and Oakland University William Beaumont School of Medicine.

749. NEUROBIOLOGY: BRAIN Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Neurobiology Presentation time: 12:00 pm–2:00 pm E151 749.1 Embryo-Form Project : How Accurate Was Miss D. Padget? Study of the Human Venous Cerebral System. R. Tonnelet, Y. Renard, E. Micard, M. Fauvel, M. Perez, M. Labrousse, M. Braun. CHU Nancy, France, Faculté de Médecine Université de Lorraine, France and Faculté de Médecine—Université de Reims Champagne Ardenne, France. E152 749.2 Blood Supply to the Human Dentate Nucleus by Cerebellar Arteries. S. Kim, H. Yang, Y. Lee, H. Kim, H. Lee. Yonsei University College of Medicine, Republic of Korea, Gachon University Medical School, Republic of Korea, Department of Radiology, Yonsei University College of Medicine, Republic of Korea. E153 749.3 Diversity of Microvascular Endothelial Cell Markers in Different Regions of the Human Brain. S. Mbagwu, L. Filgueira. University of Fribourg, Switzerland and Nnamdi Azikiwe University, Nigeria. E154 749.4 Sleep, Glymphatic Activation and Phantosmia Inhibition. R.I. Henkin, M. Abdelmeguid. Center for Molecular Nutrition and Sensory Disorders.

MONDAY BIOCHEMISTRY

Biochemistry and Molecular Biology 750. EDUCATION AND PROFESSIONAL DEVELOPMENT THROUGH THE ACADEMIC AND CAREER PIPELINE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B1 750.1 Assessing Accreditation at the ASBMB: Surveying Our Constituency. J.T. Tansey, L. Carastro, D.M. Dean, P. Kennelly, D. Martin, A.J. Wolfson, J.J. Provost. Otterbein University, The University of Tampa, The University of Saint Joseph, The Virginia Polytechnic Institute, St. Mary’s University of Minnesota, Wellesley College and The University of San Diego. B2 750.2 An Effective Workshop Model for Graduate Student and Postdoctoral Fellow Career Development. S. Feeney, J.M. Barral, J.M. Hendershot, G. Hunt, E.A. Siebrasse. University of California at Davis, The University of Texas Medical Branch, Cayman Chemical Company and American Society for Biochemistry and Molecular Biology. B3 750.3 Use of Eyetracking Technology to Determine Biochemistry Expert-Novice Differences in Reading Metabolic Pathways. K. Linenberger Cortes. Kennesaw State University. B4 750.4 Support and Expectations for Biochemistry and Molecular Biology Faculty Promotion and Tenure at PUI Institutions. K.L. Cortes, R.L. Angotti, J. Provost, M.A. Benore. Kennesaw State University, University of Washington Bothell, University of San Diego and University of Michigan Dearborn. B5 750.5 MAMS–A Biochemistry and Molecular Biology Rich Bridge Program to Health Professional School. M.A. Taylor. Pacific Northwest University of Health Sciences and Heritage University. B6 750.6 First Year Medical Student Authorship of Clinical Cases. R.C. Bateman; Jr., P. Chastain, M. Stephens. WCU College of Osteopathic Medicine and UI College of Medicine at Rockford. B7 750.7 Mental Health Crisis in Graduate Education: The Data and Intervention Strategies. T.M. Evans, L. Bira, J. Beltran-Gastelum, L. Weiss, N. Vanderford. UT Health San Antonio, St. Mary’s Univ. and Univ. of Kentucky. B8 750.8 Using Collaborative Problem Sets to Facilitate Learning in the Online Thermodynamics Classroom. D. Dean. University of Saint Joseph. B9 750.9 Mentorship Training for Postdoctoral Researchers: Results from a Four Week Intervention Program. C.G. Pena, T. Evans, S. Mustafa, L. Moreno, L. McManus. UT Health.

B10 750.10 The Women in Science Undergraduate Organization at Otterbein University: Best Practices and Outreach Efforts. T.B. Hyatt, H.M. Bailey, J.T. Tansey. Otterbein University. B11 750.11 A Potential Solution to the Continuing Problem of Not Enough NIH RO1 Funding to Minority Investigators. J.J. Guers, J. Gwathmey, G. Haddad, D.E. Vatner, S.F. Vatner. Rutgers University—New Jersey Medical School and Howard University.

751. ENGAGING AND RETAINING STEM STUDENTS IN THE LEARNING PROCESS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B12 751.1 Structural Modeling and 3-D Printing of the PTF1-L Heterotrimeric Complex: Understanding the Structure and Function of a Ptf1a P191T Hypomorphic Mutation That Causes Pancreatic Aplasia in Children. L. Davies, C. Zwillenberg, J. Diaz, S. Nelson, A. Ali, S. Staford, T. Lefeld, M. Bowers, A. Gilliam, S. Hooks, E. Maysent, H. La Force, J. McKenzie, V. Armenta, I. Baker, C. Bennette, L. De Leon, A. Escobar, R. Faulkner, L. Morel, W. Morel, A. Garcia, M. Garcia, N. Grimes, I. Hernandez, E. Jordan, Y. Martinez, L. Montelongo, K. Montes, S. Njoku, A. Pacheco, M. Pittman, V. Pittman, E. Sandoval, E. Santana, H. Starnes, D. Morales, M. Flores, L. Tudon, A. Burkhaulter, N. Ali, W. Coats, R. MacDonald. Hillcrest High School and University of Texas Southwestern Medical Center at Dallas. B13 751.2 Predictors of Success on the MCAT for PostBaccalaureate Pre-Medicine Students. Y. Dobrydneva, L. Schwartz. GWU School of Medicine and Health Sciences. B14 751.3 Design and Implementation of an Experiential Learning Workshop for Upper-Level Undergraduate Science Majors. S.J. Connelly, R. Johnson, J.L. Mills. Rochester Institute of Technology. B15 751.4 Modeling a Protein Story (MAPS): A ProjectBased Learning Program Connecting Gene and Protein Sequence and Structure-Function Relationships with Physical Models. D.H. Munzenmaier. Milwaukee School of Engineering. B16 751.5 The Evolution of Hemocyanin. M. Schuld, R. Bhatia, S. Bobber, B. Dorava, B. Fragoso, O. Johanneck, K. Ledger, B. Mclaughlin Haralson, A. Mitchell, J. Perez, T. Rivera, J. Ruiz, S. Sheikh, A. Ya, J. Perez. Ronald Wilson Reagan College Preparatory High School. B17 751.6 Withdrawn. B18 751.7 Making Connections: Impact of Primary Literature Assignments on Lecture and Laboratory Learning. K.R. Miller. University of Mount Union.

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BIOCHEMISTRY MONDAY B19 751.8 Promoting Rural Student Enthusiasm for STEM by Establishing a Model Biotechnology Company in Their High School. M. Koci, B. Boller, R. Ali, A. Orders. NC State University and Bertie Early College High School. B20 751.9 IONiC VIPEr: Online Resources for an Active Classroom in Bioinorganic Chemistry. S. Smith, A. Bentley, H.J. Eppley, E. Jamieson, A.R. Johnson, C. Nataro, J. Raker, B.A. Reisner, J.L. Stewart, L.A. Watson, N.B. Williams. University of Michigan-Dearborn, Lewis and Clark College, DePauw University, Smith College, Harvey Mudd College, Lafayette College, University of South Florida, James Madison University, Hope College, Earlham College, Claremont McKenna, Pitzer and Scripps Colleges. B21 751.10 Integrating Research Experiences Into Introductory Biology Laboratories to Engage Undergraduate Students in STEM Learning. D. Zies, M. Stebar, D. Baker. University of Mary Washington. B22 751.11 Scientific Community Outreach in Central Texas. J.A. Bondoc, J. Ream. Texas State University. B23 751.12 Observations and Practical Tips on Metal Affinity Chromatography and Protein Refolding Techniques. C.N. Tovar, J.A. Mullins, O.O. Odunuga. Stephen F. Austin State University. B24 751.13 A Topic-Based Approach for Teaching Metabolism in a Flipped Classroom. K.E. Johanson. Xavier University of Louisiana. B25 751.14 Flipped Classroom Approaches Lead to No Improvement in Learning Outcomes or Student Perceptions. J.A. Arnott, S.L. Planey. The Commonwealth Medical College. B26 751.15 Proxies for Success—How Application Changes Correlate to PhD Path Pursuit for a Small Diversity Research Program. C.R. Shadding, D. Whittington. Washington University in St. Louis—School of Medicine, Strategic Evaluations and Inc.

752. LABORATORY COURSES

B30 752.4 Ammonium Sulfate Selectively Extracts Invertase Activity from a Mixture of Precipitated Yeast Proteins. R.M. Cook, A.J. Gontkovic, J. Lawrence, A. Timerman. University of Wisconsin-Stevens Point. B31 752.5 The Role of Skill Assessments in an Undergraduate Non-Majors Biochemistry Lab Course. O.M. Hart. Purdue University. B32 752.6 Genetic Engineering of Human Cells Using Lentivirus in a High School Laboratory Course. C. Safranek, E. Ross, M. Rosenberg, A. Cole, A. Chandra, L. Pemberton, H. Zarrinnegar, A. Alonzo, L. De, R. Sweeney. The Nueva School. B33 752.7 Establishing a Zebrafish Laboratory Exercise to Be Used in a Course-Based Undergraduate Research Experience (CURE) in Introductory Biology. L. Bruton, A. Gruber, K. Kalo, J. Morrissette. Lawrence Technological University. B34 752.8 Undergraduate Student Research in Quantitative Analysis of Transcription Elongation Perturbation Networks Using Mass Spectrometry. L. Bedard, A. Boyd, N. Dyer, Z. Golay, W. Smith-Kinnaman, N. Alakhras, A.L. Mosley. DePauw University and Indiana University School of Medicine. B35 752.9 Design of a Robust Undergraduate Biochemistry Laboratory Course Based on a Modified and Expanded Bovine Serum Albumin Purification Scheme. T. Odunuga, N. Cheatwood, J. Mullins, M. Harris. Stephen F. Austin State University. B36 752.10 Design and Implementation of a SemesterLong Course-Based Research Experience in Biochemistry That Is Suitable for Introductory and Upper Level Students. S. Shelby. Florida Southern College. B37 752.11 Adaptation of Conceptual Frameworks from Public Health to Promote Deeper Learning in a Biochemistry Lab Course Curriculum. B. Smith-Keiling. University of Minnesota.

753. DNA REPLICATION

Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B27 752.1 Measurement of BCAA in Milks and Supplements with an Enzyme Assay: Confirmation of Results with HPLC. K. Keenan, D. Do, K. Ngo. Stockton University and Absegami High School. B28 752.2 A POGIL Based Laboratory Manual for Undergraduate Biochemistry. A. Wright, B. Davis, A. Krzyslak. Marymount University, Shenandoah University and Bellarmine University. B29 752.3 Assessing Student Competencies Using Rubrics Associated with Figure Legends and Ability to Perform the Bradford Assay in a 400-Level Undergraduate Course on Proteomics. R. Shipman, J. Grant. University of Wisconsin-Stout.

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Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B38 753.1 A Novel Reductase-Independent Role of Nuclear Ribonucleotide Reductase. Y. Aye. Cornell U & Weill Cornell Med. B39 753.2 Bypass and Misincorporation of DNA Polymerases at DNA-Peptide Crosslinks. C.A. Sedgeman, F.P. Guengerich. Vanderbilt University. B40 753.3 Defining Lagging-Strand Polymerase Dynamics in Vivo. D. Smith. New York University. B41 753.4 Mechanism of DNA Binding by Human DNA Ligase 1. T. Jurkiw, P. O’Brien. University of Michigan. B42 753.5 An Evolutionary Conserved DNA Replication Stress Response in Planarian. R. Tirgar, U. Shamoon, L. Akpati, N. Sawyer, E. Nam. University of Saint Thomas.

MONDAY BIOCHEMISTRY B43 753.6 Single Amino Acid Substitutions Affect the Stability of the Dimer Interface of the E. coli β Clamp. J. Baez. Colgate University. B44 753.7 Acetylpyrazine Thiosemicarbazone Inhibiting Topoisomerase II. L.C. Ngo, G. Stults. Tennessee Technological University.

754. DNA DAMAGE Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B45 754.1 Assessing DNA Cross-Linking and Repair in Human Leukemia Cells. P.M. Le, J.T. Millard. Colby College. B46 754.2 Determination of Escherichia coli Genes Important for Dna Repair Following Alkylation. C. Joshi, A. Aiken, E. Nash, K. Wong, A. Carlson, B. Leifer, M. Muenter, P. Beuning. Northeastern University. B47 754.3 Effects of DNA Bending on T=C CPD Deamination. K. Wang, J. Taylor. Washington University in St. Louis. B48 754.4 A Dipyrimidine Sequence Library for Determining the Sequence Dependence of UV-Induced Cyclobutane Pyrimidine Dimer Formation. C. Lu, J.-S. Taylor. Washington University in St. Louis. B49 754.5 Effects of H4K16 and Gene Mutation on Sensitivity to DNA Damaging Agents and Silencing. B. Enya, T. Young, A. Kirchmaier. Savannah State University and Purdue University. B50 754.6 Determination of E. coli Cellular Factors That Contribute to Survival upon Exposure to the Alkylating Agent Benzyl Bromide. A. Aiken, S. Bellou, K. Wong, E. Nash, C. Kramer, B. Leifer, M. Muenter, P. Beuning. Northeastern University. B51 754.7 Identification of the Dimer Exchange Interface of the Bacterial DNA Damage Response Protein UmuD. D.A. Murison, R. Timson, P. Beuning. Northeastern University. B52 754.8 A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells. M.K. Zafar, L. Maddukuri, N.R. Penthala, A. Ketkar, S. Eddy, M.R. Reed, P.A. Crooks, R.L. Eoff. University of Arkansas for Medical Sciences. B53 754.9 Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment. M.R. Reed, L. Maddukuri, E. Helm, A.C L. Bostian, M.K. Zafar, R.L. Eoff. University of Arkansas for Medical Sciences, University of Central Arkansas and Arkansas State University.

755. HISTONE MODIFICATIONS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B54 755.1 Chemical Tools to Study the Molecular Mechanisms of the CoREST Complex-Chromatin Interactions. M. Wu, D. Hayward, J.H. Kalin, Y. Song, J.W. Schwabe, P.A. Cole. Johns Hopkins University School of Medicine and University of Leicester, United Kingdom. B55 755.2 Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. D. Zhang, Z. Xie, D. Chung, Z. Tang, H. Huang, L. Dai, S. Qi, J. Li, G. Colak, Y. Chen, C. Peng, H. Ruan, D. Wang, L.M. Jensen, O. Kwon, S. Lee, S.D. Pletcher, M. Tan, D.B. Lombard, K.P. White, H. Zhao, J. Li, R.G. Roeder, X. Yang, Y. Zhao. Medical University of South Carolina, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People’s Republic of China, University of Minnesota Twin Cities, Yale University School of Medicine, University of Michigan, Kyungpook National University, Republic of Korea, Yale University and Yale School of Medicine. B56 755.3 A “Tail” of Unusual Histone H2A Variants in Bdelloid Rotifers. M. Ebijoyeldhas, A.C. Jones, M. Boerma, S.D. Byrum, L.M. Orr, A.J. Tackett, A. Schurko. Hendrix College and University of Arkansas for Medical Sciences. B57 755.4 Systematic Mutational Analysis of Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Active Site Suggests Single Phe/tyr Switch Position to Regulate Product Specificity. A. Canning, N. Alicea-Velazquez, M. Cosgrove. SUNY Upstate Medical University. B58 755.5 Discovering Selectivity in BET Bromodomain Epigenetic Regulation. M. Olp. Medical College of Wisconsin. B59 755.6 Identification of Inhibitors of Human Histone Methyltransferases SUV39H1 and SUV39H2. A.C. Spencer, A. Jahan, Z. Shaikh, K. Liu. Augusta University. B60 755.7 Biological Function and Histone Recognition of Family IV Bromodomain-Containing Proteins. J.T. Lloyd, A. Poplawaski, M.Y. Lubula, S. Carlson, J. Gay, K.C. Glass. Albany College of Pharmacy and Health Sciences (Vermont Campus). B61 755.8 Class I-Specific HDAC Inhibitor Stimulates the Expression of Npr1 in Haplotype Mice by Enhanced Histone Acetylation at Different Lysine Residues. P. Kumar, V.R. Gogulamudi, C. Nguyen, K.N. Pandey. Tulane University Health Sciences Center and School of Medicine. B62 755.9 Regulation of Histone Methylation via Methionine Metabolism. S.A. Haws, J.M. Denu. University of Wisconsin-Madison, Wisconsin Institute for Discovery and University of Wisconsin-Madison School of Medicine and Public Health. B63 755.10 A Novel “Dual Substrate” Kinetics Assay Suggests the Presence of Two Active Sites in the MLL1 Core Complex. K. Namitz, J. Mahmud, N. Alicea-Veláquez, M. Cosgrove. SUNY Upstate Medical University.

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BIOCHEMISTRY MONDAY B64 755.11 Molecular Characterization of UHRF1 and UHR. F2 A. Winkler, B. Albaugh. Eastern Michigan University. B65 755.12 Molecular Characterization of the PHD Domains of UHRF1 and UHRF2. A. Mohamed, B. Albaugh. Eastern Michigan University. B66 755.13 Affinity Characterization of TTD Domain of UHRF Histone Reader Protein. T.S. Petzold. Eastern Michigan University. B67 755.14 Identifying Dysregulated Epigenetic Enzymes in Castrate-Resistant Prostate Cancer Development. J. Lee, B.H. Yang, N.H. Damaschke, M.D. Boersma, W.H. Huang, E. Corey, D.F. Jarrard, J.M. Denu. University of Wisconsin— Madison, Auburn University and University of Washington. B68 755.15 GPS2 Regulates Mitochondrial Biogenesis via Mitochondria Retrograde Signaling and Modulation of NuclearEncoded Mitochondrial Genes Core Promoter Accessibility. M.D. Cardamone, B. Tanasa, C.T. Cederquist, J. Huang, K. Mahdaviani, J.L. Orofino, C. Lentucci, W. Li, M.G. Rosenfeld, M. Liesa, V. Perissi. Boston University, Stanford University, University of California Los Angeles and University of California San Diego. B69 755.16 The Effect of UVB Irradiation on Histone H4. C.R. Musson, C. Zurita-Lopez. California State University at Los Angeles. B70 755.17 New Method for Isolation of Native Yeast Nucleosomes—Development and Application. V.I. Kuznietsov, C.A. Fox, J.M. Denu. University of Wisconsin-Madison. B71 755.18 Understanding the Role of the Histone Demethylase LID in the SIN3 Histone Modifying Complex in Drosophila melanogaster. A. Chaubal, L. Pile. Wayne State University.

756. TRANSCRIPTIONAL REGULATION (I) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Transcriptional Regulation (II), Tuesday B72 756.1 Biochemical Analysis of the Zinc Uptake Regulator (Zur) from Klebsiella oxytoca. L. Khacheryan, Y. Xie, G. Gallas, J. Hernandez. Midwestern University. B73 756.2 Biochemical Analysis of Zinc Transporter Regulator from Klebsiella oxytoca: In Vitro and in Vivo Effects on Protein Function. Y. Xie, L. Khacheryan, G. Gallas, J. Hernandez. Midwestern University. B74 756.3 Upregulation of CYP17A1 by Sp1-Mediated DNA Demethylation Confers Temozolomide Resistance Through DHEA-Mediated Protection in Glioma. T. Hsu. Taipei Medical University, Taiwan.

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B75 756.4 The Sp1 in Astrocyte Plays an Important Role in Neurogenesis. J. Hung, W. Chang. Department of Biotechnology and Bioindustry Science, NCKU, Taiwan, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei Taiwan. B76 756.5 Transcriptional Regulation by Mediator Kinases During Starvation or Proliferation. J.D. Rubin, R.D. Dowell, D.J. Taatjes. University of Colorado Boulder. B77 756.6 Heme Induces HAP4 Transcription and Mitochondrial Respiration. T. Zhang, A. Vancura. St.John’s University. B78 756.7 Zinc-Dependent Transcriptional Regulation in Paracoccus denitrificans. D.P. Neupane. New Mexico State University. B79 756.8 Stat3 Is a Upstream Regulator of Granzyme g That Triggers the Minor Zygotic Gene Activation in Mouse Preimplantation Embryo. H. Ou-Yang, S. Wu, L. Sung, C. Chen. Institute of Biotechnology, National Taiwan University, Taiwan, Department of Animal Science and Technology, National Taiwan University, Taiwan, Department of Life Sciences and National Chung Hsing University, Taiwan. B80 756.9 Using Artificial Transcription Factors to Induce Differentiation into Cardiomyocytes. E.A. Heiderscheit, A. Eguchi, M.J. Wleklinski, M.C. Spurgat, A.Z. Ansari. University of Wisconsin—Madison. B81 756.10 The Role of Noncoding Genetic Elements in the Transcriptional Regulation of the Voltage-Gated Sodium Channels SCN1A and SCN8A. G.S. Inglis, A. Escayg. Emory University. B82 756.11 An Analysis of Cycling DOF Factor-Like Genes and Their Expression in Physcomitrella patens. J.C. Pang, K.A. Hicks. Kenyon College. B83 756.12 O-GlcNAc Regulates Erythroid Genes Controlled by GATA-1. Z. Zhang, S. Graw, E. Tan, D.C. Koestler, K.R. Peterson, C. Slawson. The University of Kansas Medical Center. B84 756.13 Elucidating a Putative Enhancer Element for the Human LAT Gene. G. Ghanim, T.S. Finco. Agnes Scott College. B85 756.14 Rdl Expression Impacts Circadian Rhythm and Locomotion in Drosophila melanogaster. S. MacDonald, R.P. Rogers. Wentworth Institute of Technology. B86 756.15 Molecular Characterization of HlyU, a Global Regulator of Vibrio vulnificus Virulence Genes. S. Choi, Z. Lee, Y. Bang, K. Jang. Seoul National University, Republic of Korea, and UT Southwestern Medical Center. B87 756.16 Smad4-Dependent TGF-β Signaling Directly Up-Regulates Notch Receptor in Cerebrovascular Endothelial Cells. Y. Lan, X. Cheng. Institute of Biotechnology, People’s Republic of China, Institute of Biotechnology, People’s Republic of China. B88 756.17 Regulation of Cellular Proliferation in B-Cell Acute Lymphoblastic Leukemia by Ikaros. E. Dovat, J.L. Payne, C. Song, D. Desai. Pennsylvania State University and Pennsylvania State University College of Medicine.

MONDAY BIOCHEMISTRY B89 756.18 Transcriptional Regulation of Cell Cycle Progression in T-Cell Leukemia. J.L. Payne, M. Soliman, E. Dovat, M. Kapadia, C. Song, S. Dovat. Loma Linda University School of Medicine and Penn State College of Medicine. B90 756.19 MSK-1 Mediated Histone H3 Phosphorylation Is Critical for Ethanol-Induced Inhibition of IL-2 Gene Transcription in CD4+ T Lymphocytes. S. Ghare, S. JoshiBarve, C. McClain, S. Barve. University of Louisville and Robley Rex VAMC. B91 756.20 Inhibiting Pathways Involved in B-Cell Development Enhances Sensitivity of B-Cell Acute Lymphoblastic Leukemia to Glucocorticoids. M.A. Pufall, K. Kruth, M.A. Fang, D. Shelton, O. Abu-Halawa, S.K. Tasian, M. Kampmann. University of Iowa, Bio-Rad, Coe College, Children’s Hospital of Philadelphia, University of California San Francisco.

757. NON-CODING RNAS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B97 757.1 Targeting High-Mobility Group Box2 by miR-127 Modulates Pluripotency of Mouse Embryonic Stem Cells and Contributes to Aggressiveness of Hepatocellular Carcinoma. Y. Zhao, Z. Yang, L. Wang. University of Connecticut, Veterans Affairs Connecticut Healthcare System and Yale University. B98 757.2 Tthe Role of LncRNA H19 in Estrogen-Induced Cholestatic Injury. X. Li, R. Liu, D. Zhao, W. Pandak, P. Hylemon, H. Zhou. Virginia Commonwealth University. B99 757.3 miRNA-Mediated Crosstalk Between Wnt3a and TGFβ3 in Osteoblast Differentiation. S. Fushimi, T. Nohno, S. Nishimatsu, N. Katase, K. Terada, M. Katsuyama, M. Demura, K. Saijoh, H. Nagatsuka, H. Katsuyama. Kawasaki Medical School, Japan, Okayama University, Japan and Kanazawa University, Japan. B100 757.4 Non-Coding RNA Editing Involved in Adipose Dysfunction During Aging. A. Seidler, A. Marcelo, J. Page, N. Santanam. Marshall University, Marshall University School of Medicine and Cheyney University. B101 757.5 “Listening In”—The Cross-Talk Between Mother and Infant Through Exosomal microRNAs in Breast Milk. J.D. Kraft, I. Altosaar. University of Ottawa, Canada. B102 757.6 Functional Characterization of DiabetesInduced Long Non-Coding RNA Dnm3os in Macrophages. S.C. Das, M.A. Reddy, P. Senapati, M. Wang, L. Lanting, H. Oh, S. Devaraj, R. Natarajan. City of Hope, Texas Children’s Hospital and Houston. B103 757.7 Developing a Method to Identify and Study the Transcriptome of miRNAs Important in Myogenesis. G. Salant, J. Goodrich, J. Kugel. University of Colorado and Boulder.

B104 757.8 Role of Long Non-Coding RNA Alive in Response to Angiotensin Ii in Vascular Smooth Muscle Cells. V. Amaram, S. Das, A. Leung, A. Reddy, L. Lanting, R. Natarajan. City of Hope. B105 757.9 Regena/NOT2 Is Essential for Gene Silencing by microRNAs. T. Zbornik, K. Andersen, S. Bowden, C. Reinke. Linfield College. B106 757.10 A Novel Long Non-Coding RNA Modulates Macrophage Phenotype During Diet-Induced Obesity. K. Stapleton, Z. Chen, M. Reddy, L. Lanting, A. Leung, J. Dieuliis, R. Natarajan. City of Hope and University of Maryland. B107 757.11 The Neuroprotective Role of miR-1017, a 3′ Tailed Mirtron. M. de Cruz, A. Flynt. University of Southern Mississippi. B108 757.12 Haematological and miRNAs (let-7g, miR-21, miR-141) Expression Modulation Profile in Serum Samples of Human Prostate Cancer. A.B. James, A.O. Fadaka, O.A. Magbagbeola, A. Oturu, O.O. Kolawole, A. Ogunijimi, T. Oshodi, M. Habeebu, F.O. Onawoga, E.O. Ajogbeje. University of Lagos, Nigeria, and Afe Babalola University/ University of Lagos, Nigeria. B109 757.13 Cyclosporin A Alters Expression of Renal MicroRNAs: New Insights into Calcineurin Inhibitor Nephrotoxicity. Y. Bai, C. King, C. Francis, J. Gooch. Philadelphia College of Osteopathic Medicine and Emory University. B110 757.14 Transcriptome-Wide Mapping of the miR-122 Targetome Revealed Its Mechanistic Role in the Maintenance of Liver Homeostasis. J.M. Barajas, J. Luna, K. Teng, R. Darnell, K. Ghoshal. The Ohio State University and The Rockefeller University. B111 757.15 New Biotechnology to Inhibit microRNA Activity in Vivo and in Vitro. B. Amendt, H. Cao, W. Yu, T. Sharp, S. Eliason. University of Iowa. B112 757.16 Alteration of miR-186 Expression Modifies Inflammatory Markers in Normal Epithelial and Prostate Cancer Cell Models. S. Suman, D.Z. Jones-Reed, M.L. Schmidt, G.J. Clark, C. Klinge, S. Barve, K.S. Kimbro, L.R. Kidd. University of Louisville and North Carolina Central University. B113 757.17 Investigation of PAX3-FOXO1 Effect on NEAT1 Expression in Alveolar Rhabdomyosarcoma Cells. V.A. George, B. McDaniel, K.E. Johanson. Xavier University of Louisiana. B114 757.18 MicroRNA-506-3p as a Differentiation Agent for Neuroblastoma. M. Sousares, L. Du. Texas State University. B115 757.19 Functional Non-Coding ncRNA in Vascular Epigenetics: Redox Editing and Structural Relations of Factors. J.H. Wissler. ARCONS Institute of Applied Research & Didactics, Germany. B116 757.20 Quantifying Downstream Regulatory Output as a Way to Understand the Biogenesis Pathways of Endogenous siRNAs in C. elegans. L.T. Izzo, E.M. Youngman. Villanova University. B117 757.21 Nonstop Decay in C. elegans: Examination of a Possible Role for Small Noncoding RNAs. E.M. Youngman. Villanova University.

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BIOCHEMISTRY MONDAY

758. PROTEIN CHEMISTRY, SYNTHESIS AND TURNOVER Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B118 758.1 Positive Charge in the n-Region of the Signal Peptide Contributes to Efficient Post-Translational Translocation of Small Secretory Proteins. M. Liu, J. Sun, Y. Xiong, J. Cui, H. Guo. Tianjin Medical University General Hospital, People’s Republic of China, and The University of Michigan. B119 758.2 CEBPD Is an Early Endoplasmic Reticulum Stress Response Gene Implicated in Breast Cancer Cell Survival. N. Sheshadri, S. Sharan, E. Sterneck. National Cancer Institute. B120 758.3 A Bifunctional Fusion Enzyme with DNA Polymerase and dUTPase Activities. A.K. Dash, S. Bhamidipati, M.B. Rashid. University of Houston-Clear Lake. B121 758.4 The Molecular Basis of Rapid and Selective Diffusion in the Nuclear Pore Complex. S. Sparks, R. Hayama, M.P. Rout, D. Cowburn. Albert Einstein College of Medicine and Rockefeller University. B122 758.5 Llama Hemoglobin Binding to Heterologous Haptoglobins. O.A. Vanderpuye, K. Troutman, N. Kellam, C. Dunn. Albany State University.

759. BIOCHEMISTRY AND BIOPHYSICS OF PROTEINS AND TRANSLATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B123 759.1 Extra-Ribosomal Function of Bacterial Ribosomes: Modulation of Enzyme Activities. A. Shekhtman, C. DeMott, S. Majumder, S. Reverdatto. University at Albany and State University of New York. B124 759.2 In Vivo and in Vitro Studies of RRF (Ribosome Recycling Factor) Revealed That Its Major Function Is to Release mRNA from the Post-Termination Complex and Not Splitting of the Ribosomal Subunits. F. Quaglia, H. Kaji, A. Kaji, Y. Inokuchi. Thomas Jefferson University, University of Pennsylvania and Teikyo University, Japan.

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B125 759.3 Assembly and Disassembly of the Hibernating Bacterial 100S Ribosome. A. Basu. Saint Louis University. B126 759.4 The Cellular Demand for Protein Synthesis Influences the Ribosome Maintenance Program in Vivo. J.C. Price. Brigham Young University. B127 759.5 Differential tRNAser Expression Regulates Translation Rate of a Biofilm Master Regulator During Bacillus subtilis Biofilm Development. G. Di Cecco, J. Greenwich, Y. Chai. Northeastern University. B128 759.6 A Non-Canonical Function of Leucyl tRNA Synthetase Negatively Regulates Skeletal Myogenesis. K. Son, N. Khanna, A. Banerjee, S. Martinis, J. Chen. University of Illinois at Urbana-Champaign. B129 759.7 Translational Regulation of Gene Expression in Mycobacterium: A Means for Coordinating the Expression of Functionally Related Proteins. M.E. Saks, J. Oh, A.C. Deets, G.M. Mastorakos, S.A. Martinis. University of Illinois.

760. PROTEIN INTERACTIONS AND BINDING (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Protein Interactions and Binding (I), Sunday Protein Interactions and Binding (III), Tuesday B130 760.1 Deconstructing the Peptide Specificity of TCR Recognition. T.P. Riley, J. Mendoza, L. Hellman, K. Garcia, B. Baker. University of Notre Dame and Stanford School of Medicine. B131 760.2 Native Proteomics: A New Approach to Protein Complex Discovery and Characterization. P.D. Compton, O. Skinner, N. Haverland, L. Fornelli, P. Doubleday, H. Seckler, L. Schachner, N. Kelleher. Northwestern University. B132 760.3 Expression, Purification and Initial Characterization of the Coiled-Coil 2-3 Region of Atg11, a Central Organizer of Selective Autophagy Initiation. C. Zois, B. Kennedy, S.K. Backues. Eastern Michigan University. B133 760.4 Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Y. Lin. University of Texas Southwestern Medical Center. B134 760.5 Identification of Different Binding Partners of the F-BAR Proteins Cdc42 Interacting Protein 4 (CIP4) and Formin Binding Protein 17 (FBP17) in Cortical Neurons. M.E. McDermott, R.J. Taylor, K.L. Taylor, E.W. Dent. University of Wisconsin-Madison, University of Wisconsin School of Medicine and Public Health, University of Wisconsin School of Medicine and Public Health Madison and Neuroscience.

MONDAY BIOCHEMISTRY B135 760.6 Characterization of ppGpp-Binding Proteins in Escherichia coli. D.T. Nguyen, C.H. Jung. Chonnam National University, Republic of Korea. B136 760.7 Lactoferrin Interacts with SPLUNC1 to Amelioate Lipopolysaccharide-Induced Inflammation of Human Nasal Epithelial Cells. C. Chen, Y. Tsou, H. Chen. National Chung Hsing University, Taiwan and Da-Yeh University, Taiwan. B137 760.8 Affinity and Structural Characterization of Human AT Hook Motif Variants. K. Dobbins, K.L. Buchmueller. Furman University. B138 760.9 Analysis of Complex Interactions Between the Essential Subunits, Pam16, Tim44, and Tim50, of the Hsp70Based Mitochondrial Protein Import Machinery. N.L. Yan, S. Ting, B. Schilke, E.A. Craig. University of Wisconsin. B139 760.10 Examining How Allosteric Mutations Affect Ligand Binding and Specificity on Dihydrofolate Reductase. M. Alfonso, M. Okondo, N.M. Goodey. Montclair State University. B140 760.11 Novel Bryostatin-1 Targets: Mammalian Unc13-1 and Unc13-2 Isoforms. F.A. Blanco, S. Pany, A.A. Ghosh, Y. You, J. Das. University of Houston. B141 760.12 Carboxyl-Terminus of TFG Regulates Directional Movement of COPII Transport Carriers. S. Block, M. Hanna, A. Audhya. University of Wisconsin-Madison. B142 760.13 Probing the Pal-Peptidoglycan Interaction. S. Phadke, S. Stanton, J. Pierce, C. LaClair, C. Hall, L. Michel. Rochester Institute of Technology. B143 760.14 The Role of a Flexible Loop in Metal Transfer Between Periplasmic Zinc Proteins. S.H. Fullam. New Mexico State University. B144 760.15 Determining Histone Deacetylase 8 Substrates Using Non-Natural Amino Acids. J. Lopez, S. Haynes, J. Majmudar, B. Martin, C. Fierke. University of Michigan. B145 760.16 Endocytosis of Phosphorothioate Antisense Oligonucleotides (ASO) by the Stabilin Receptors. A. Egger, B. Kellar, C.M. Miller, E.N. Harris. University of Nebraska-Lincoln. B146 760.17 Identifying Serine Proteases Involved in HMPV F Cleavage. J.T. Kinder. University of Kentucky. B147 760.18 Molecular Mechanisms Associated with Early Onset Primary Dystonia (DYT16) Caused by Mutations in PACT. S.B. Burnett, L. Vaughn, R. Patel. University of South Carolina. B148 760.19 Determination of DNA Binding Interactions for Individual Constructs of the PICKLE Protein’s DNA Binding Domain in Arabidopsis thaliana. K.J. Ernzen, K.K. Ho, J. Ogas. Viterbo University and Purdue University. B149 760.20 Cellular Protein P32/gC1qR Recruits PKC to Viral Protein ICP34.5 and Facilitates HSV Nuclear Egress. C. Zhang, S. Wu, Y. Wang, L. Zhang, S. Pan, Y. Liu, M. Yang, D. Chen, J. Wang, B. He, Y. Cao. Nankai University, People’s Republic of China, and University of Illinois. B150 760.21 Generation of TYRO3 Receptor Tyrosine Kinase Clones to Study Interactions with SH2 Domain Proteins in the Retinal Pigment Epithelium. L. Harris, S. Shelby. Florida Southern College. B151 760.22 Multiple Approach to Determine Protein-Protein Binding Affinity of Calcineurin Homologous Protein Isoforms 1 and 2 and the Sodium Hydrogen Exchanger Isoform 1. C.N. Marshall, M.A. Wallert, M.A. Wallert, J.J. Provost. University of San Diego and Bemidji State University.

B152 760.23 Bacteriophytochromes in Myxobacteria: Implications for Light-Control of Cell Development. G.C. Tracy, K.D. Gallagher, J.D. Varela, D. Bizhga, P. Duong, A. Nugent, E.A. Stojkovic. Northeastern Illinois University. B153 760.24 BECN Homologs and ATG14 Form a Metastable Coiled-Coil to Mediate Autophagy. S. Sinha, M. Su, Y. Li, B. Levine, C. Colbert. North Dakota State University, Howard Hughes Medical Research Institute and University of Texas Southwestern Medical Center.

761. PROTEIN STRUCTURE AND BIOPHYSICS (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B154 761.1 Detecting Lipid Induced Structural Changes of Marburg Virus-VP40 Protein Using Hydrogen-Deuterium Exchange Mass Spectroscopy (HDX-MS). K.J. Wijesinghe, S. Urata, S. Li, R.V. Stahelin. University of Notre Dame, University of California-San Diego and Indiana University School of Medicine-South Bend. B155 761.2 Destabilization of the Non-Polar Subdomain of Hemolysin A Inhibits Hemolysis. M.R. Brunner, D. Grilley, T.M. Weaver. University of Wisconsin La Crosse. B156 761.3 Testing c-Type Heme Sources for Nontypeable Haemophilus influenzae. S. Stanton, J. Pierce, V. Sgheiza, K.L. Bren, L. Michel. Rochester Institute of Technology and University of Rochester. B157 761.4 Probing the Role of Allostery in Rho and Ras GTPases. K. Marcus, B. Ma, R. Nussinov, C. Mattos. Northeastern University and National Cancer Institute. B158 761.5 Characterizing the Interactions Between Mg2+ and a Periplasmic Lipoprotein Involved in Mg2+ Homeostasis in Salmonella enterica. T.J. Davie, J.F. May. University of Wisconsin-La Crosse. B159 761.6 Structural and Functional Insights into σ1 Receptor Ligand Binding. H.R. Schmidt, A.C. Kruse. Harvard Medical School. B160 761.7 Purification and Structural Analysis of an Uncharacterized Lytic Protein in Epstein-Barr Virus. M.D. Scheidt, K. Gorres. University of Wisconsin—La Crosse. B161 761.8 Characterization of the Ordered Domain of an Epstein Barr Viral Tegument Protein. M.E. Marlowe, K. Gorres. University of Wisconsin-La Crosse. B162 761.9 Structural Characterization of a Periplasmic Lipoprotein Associated with Magnesium Homeostasis in Salmonella enterica. D.M. Rasmussen, C. Varneerd, B. Bhattacharyya, J. May. University of Wisconsin- La Crosse. B163 761.10 Using Biophysical Characterization to Explore Suppressor of IKKepsilon Structure. M.L. Machek, F. Shikwana, S.I. Graham, I.D. Minzer, R. Wey, R. Cruz, E. Bell, J.K. Bell. University of San Diego and Westview High School.

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BIOCHEMISTRY MONDAY B164 761.11 Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation. J.F. May, D.M. Rasmussen, T.J. Davie, C. Vaneerd, E.A. Groisman, B. Bhattacharyya. University of Wisconsin-La Crosse, Yale School of Medicine and Yale Microbial Sciences Institute. B165 761.12 Structure and Stability of C19orf10 as Assessed by Circular Dichroism. V. Bortnov, D.S. Annis, D.R. McCaslin, D.F. Mosher. University of Wisconsin. B166 761.13 Evaluating the Role of Corynebacterium matruchotti MdAa in Oral Biofilm Formation. R. Tirgar, T.T. Luong, H. Ton-That. University of Saint Thomas and The University of Texas Health Science Center at HoustonMcGovern Medical School. B167 761.14 Evolutionary Fine-Tuning of Conformational Ensembles in Fimh During Host-Pathogen Interactions. V. Kalas, J.S. Pinkner, T.J. Hannan, M.E. Hibbing, J.W. Janetka, S.J. Hultgren. Washington University in St. Louis. B168 761.15 Thermodynamic Partitioning Forces at the Membrane Protein Interface. R. Mahalakshmi. Indian Institute of Science Education and Research, India. B169 761.16 Pinpointing the Divergence of Quaternary Structure in the Lysine Biosynthetic Pathway. G. Pearce, S. Watkin, J. Keown. University of Canterbury, New Zealand and University of Auckland, New Zealand. B170 761.17 Molecular Insights Into the Structural Stability and Biological Activity of T4 Bacteriophage DNA Polymerase Processivity Factor. V. Jain, M.I. Singh. IISER Bhopal, India. B171 761.18 Toward the Structure of PE5-PPE4-EspG3 Heterotrimer from Mycobacterium smegmatis to Elucidate PEPPE Dimer Recognition by Cognate EspG. Z. Williamson, W. Ciocca, R. Reed, K. Korotkov. University of Kentucky and Eastern Kentucky University. B172 761.19 An Automated Method for the Correction of Unsubstantiated Ramachandran Outliers in Protein Structures. C.R. Smith, J.A. Alaniz, K.H. West, C.J. Weiss, W.R. Novak. Wabash College. B173 761.20 Structural and Functional Characterization of an F17-Like CUP Adhesin from Uropathogenic E. coli Isolate UTI89. R.D. Klein, C. Spaulding, S. Hultgren. Washington University in St. Louis School of Medicine. B174 761.21 Complex Structure of the Disulfide BondDimerized PDZ-RhoGEF and CXCR2 PDZ-Binding Motif: A New Mode of PDZ Dimerization. N.S. Spellmon, J. Holcomb, A. Niu, V. Choudhary, J. Brunzelle, C. Li, Z. Yang. Wayne State University, Life Sciences Collaborative Access Team and Georgia State University. B175 761.22 Characterization of the Role for the N-Terminal Domain on Sil1 Activities as a Nucleotide Exchange Factor and Reductase. K.A. Pareja, C. Sevier. Cornell University. B176 761.23 An Alternative Structural Model of Activation for the Anti-Anti-σ Factor PhyR and Interaction with the Anti-σ Factor NepR. J.L. Luebke, D.S. Eaton, J.R. Sachleben, S. Crosson. University of Chicago. B177 761.24 Developing Monovalent Ion Parameters for the Optimal Point Charge (OPC) Water Model. D.E. Clark, J.C. Dood, B.P. Krueger. Hope College. B178 761.25 Cooperative Binding of Cinnamon Polyphenols as Activators of Sirtuin-1 Protein in the Insulin Signaling Pathway. M. Brennemen, T. Mahfouz, A. Stockert. Ohio Northern University.

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B179 761.26 The Conformation of Apolipoprotein E4 on Discoidal and Spherical High Density Lipoproteins Using Chemical Crosslinking and Fluorescence Spectroscopy. N. Bala, K. Taiwo, V. Narayanaswami. California State University at Long Beach. B180 761.27 Correlation of Fitness Landscapes from Three Orthologous TIM Barrels Originates from Sequence and Structure Constraints. Y.H. Chan, S.V. Venev, K.B. Zeldovich, C.R. Matthews. UMass Medical School.

762. PROTEIN DYNAMICS AND FLUCTUATIONS Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B181 762.1 A Discrete SERCA N-Domain Loop Plays a Role in Pump Structural Dynamics and Functional Regulation. O.N. Raguimova, N. Smolin, E. Bovo, A.V. Zima, S.L. Robia. Loyola University Chicago. B182 762.2 Salt-Dependent Protein Splicing in Extreme Halophiles. C.J. Janton, J.N. Reitter, K.V. Mills. College of the Holy Cross. B183 762.3 Stress-Triggered Self-Association of an Enzyme Reverses Its Catalytic Activity. H. Yoo, R. Goyal, D. Drummond. University of Chicago. B184 762.4 NMR Studies of Ubc9 Mutant Identify Structural Basis for SUMO Target Selection. W.J. Placzek, M. Bjornsti, R.H. Whitaker, C. Wright, J. Onuiri. The University of Alabama at Birmingham. B185 762.5 Altered Protein Dynamics Modified the Chemical Step in Thymidylate Synthase. A.K. Ghosh, T. Abeysinghe, A. Kohen. The University of Iowa. B186 762.6 Conformational Motions Impacting Function in an Enzyme Superfamily. C. Narayanan, D.N. Bernard, K. Bafna, O.P. Choudhary, C.S. Chennubhotla, P.K. Agarwal, N. Doucet. INRS—University of Quebec, Canada, University of Knoxville. B187 762.7 Modeling Dynamics in the D-Amino Acid Oxidase Protein. L. Kueffer, W. Beyers. University of Wisconsin—Stevens Point. B188 762.8 The Effects of Nucleotides on the Conformational Flexibility and Stability of Glutamate Dehydrogenase. S. Tran, J.K. Bell, E. Bell. University of San Diego. B189 762.9 Dynamics Underlying Cytochrome P450cam Regioselectivity via 2D IR Spectroscopy. M. Thielges, E. Basom. Indiana University and Indiana Univeristy. B190 762.10 Conformational Changes in Palladin ActinBinding Domains Measured by Fluorescent Resonance Energy Transfer. S. Womack, R. Vattepu, M.R. Beck. Wichita State University. B191 762.11 Structure, Dynamics and Folding of an Immunoglobulin-Like Domain of Actin Binding Protein Palladin. R. Vattepu, M.R. Beck. Wichita State University.

MONDAY BIOCHEMISTRY

763. PROTEIN MISFOLDING AND AGGREGATION Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm B192 763.1 ATF6 Activation Remodels the Endoplasmic Reticulum Proteostasis Network to Restore Proteostasis of Pathogenic GABAA Receptors. Y. Fu. Case Western Reserve University. B193 763.2 Characterization of Anti-SOD1 Antibodies and Detection of Intermediary SOD1 Oligomers. R.S. Atlasi, R. Malik, C. Corrales, L. Tzeplaeff, N. Cashman, G. Bitan. University of California, Los Angeles (UCLA), Strasbourg University, France and University of British Columbia (UBC), Canada. B194 763.3 Engineering Hsp104 Variants to Counter Protein Misfolding. M. Jackrel, J. Shorter. University of Pennsylvania. B195 763.4 Copper-Zinc Superoxide Dismutase as a Convenient System for Assessment of Safety Margins in Vitro. R. Malik, C. Corrales, R.S. Atlasi, J.S. Valentine, T. Schrader, F. Klärner, G. Bitan. UCLA and Duisburg-Essen University, Germany. B196 763.5 Investigation of Cellular Signaling and Epigenetic Dynamics via Optogenetic Control of Nuclear Cytoplasmic Distribution. H. Yumerefendi, B. Kuhlman. University of North Carolina at Chapel Hill. B197 763.6 Role of Folding Intermediates in Initiating Aggregation of the Prion Protein. R. Moulick, R. Goluguri, J.B. Udgaonkar. NCBS and IFR, India. B198 763.7 Protein Aggregation in Ehrlichia chaffeensis During Infection of Mammalian Cells. M. Zolkiewski, D. Kuczynska-Wisnik, C. Cheng, R.R. Ganta. Kansas State University, University of Gdansk, Poland and Vanderbilt University Medical Center. B199 763.8 A Common Mechanism of Proteasome Impairment by Neurodegenerative Disease-Associated Oligomers. T.A. Thibaudeau, R. Anderson, D.M. Smith. West Virginia University and School of Medicine. B200 763.9 Host vs Virus: HSV Has Evolved to Evade Host Antiviral Mechanisms by Manipulating the Host Proteostasis Machinery. S. Weller, M. Adlakha. University of Connecticut School of Medicine. B201 763.10 Translation of Heat Shock Proteins Is Regulated by Poly(A)-Binding Protein Assembly. C.D. Katanski, J. Riback, E. Pilipenko, D.A. Drummond. University of Chicago. B202 763.11 Identifying and Ameliorating Complex Collagen Misfolding Defects. M.D. Shoulders. Massachusetts Institute of Technology. B203 763.12 Propagation of Tau Prions from Alzheimer’s Disease and Chronic Traumatic Encephalopathy Patients in Cultured Cells. A.L. Woerman, A. Aoyagi, S. Patel, S.A. Kazmi, I. Lobach, L.T. Grinberg, A.C. McKee, W.W. Seeley, S.H. Olson, S.B. Prusiner. University of California San Francisco, Daiichi Sankyo Co., Ltd. and Boston University. B204 763.13 Protein Aggregation Small Molecule Inhibitor Discovery and Mechanisms. B. Xu. Virginia Tech.

B205 763.14 Tau and α-Synuclein Protein Expression, Purification, and Their Amyloid Inhibitor Discovery. M. Marcus, F. Henderson, K. Kelly, A. Umana, P. Velander, L. Wu, B. Xu. Virginia Tech. B206 763.15 Metal Induced Conformational Changes of Alpha-Synuclein and the Role of Ambient Oxygen. H.R. Lucas. Virginia Commonwealth University.

764. ENZYME MECHANISMS, KINETICS AND ENERGETICS (II) Poster Mon. 9:00 am—McCormick Place Convention Center, Hall F Presentation time: 12:00 pm–2:30 pm Poster manning time: O  dd board # 12:00 pm–1:15 pm Even board # 1:15 pm–2:30 pm Enzyme Mechanisms, Kinetics and Energetics (I), Sunday B207 764.1 Effects of Isotopic Substitution in Enzyme and Co-Factor on Enzyme Catalyzed Hydride Transfer. C. Ranasinghe, P. Pagano, Q. Guo, C. Cheatum, A. Kohen. The University of Iowa. B208 764.2 Reactivity of Neuroglobin with H2S. M. Ruetz, J. Kumutima, M. Filipovic, N. Lehnert, R. Banerjee. University of Michigan and University of Bordeaux, France. B209 764.3 Spectroscopic Insight Into the Mechanism of Nickel-Substituted Rubredoxin, a Bioinspired Hydrogenase Mimic. M.J. Stevenson, J.W. Slater, S.C. Marguet, H.S. Shafaat. The Ohio State University. B210 764.4 Investigation of the Substrate Specificity of L-Idonate Dehydrogenase by Site-Directed Mutagenesis. S. Steiner, A. Terpening, C. McCurdy. Hanover College and Indiana University School of Medicine. B211 764.5 Temperature and Pressure Dependence of the Activity of Inteins from Extreme Thermophiles. H.Y. Comeau, J.D. Long, I.V. Pierre, J.N. Reitter, K.V. Mills. College of the Holy Cross. B212 764.6 Insights into Radical SAM Enzyme Mechanism from Lysine-2,3-Aminomutase and an S-Adenosyl-L-Methionine Analog. A. Byer, J. Broderick. Montana State University. B213 764.7 Expression, Purification, and Characterization of Codon Optimized and Mutant Variations of DszB from N. asteroides. J.J. Gumpf, K. Idrizi, L. Watkins. James Madison University. B214 764.8 Substrate Specificity of the Novel Serine Hydrolase, LipN, Implicated in the Virulence of Mycobacterium tuberculosis. D. Schemenauer, R. Johnson. Butler University. B215 764.9 Elucidating the Mechanism of Thiol Oxidase Activity of a B12-Trafficking Protein. Z. Li, A. Shanmuganathan, M. Ruetz, N. Lesniak, M. Koutmos, R. Banerjee. University of Michigan and Uniformed Services University of the Health Sciences. B216 764.10 Specificity Studies of the Aromatic Desulfinase, 2-(2′-Hydroxyphenyl)Benzenesulfinate Desulfinase (DszB) from Nocardia asteroides A3H1. D.M. Hoang, E. Smith, L. Watkins. James Madison University.

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BIOCHEMISTRY MONDAY B217 764.11 Evaluating the Catalytic Role of a Conserved Glutamate Residue in Triose