Arteriovenous Blood Metabolomics - Scripps Center for Metabolomics
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Arteriovenous Blood Metabolomics - Scripps Center for Metabolomics
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www.nature.com/scientificreports
OPEN
Arteriovenous Blood Metabolomics: A Readout of IntraTissue Metabostasis
received: 29 April 2015 accepted: 23 June 2015 Published: 05 August 2015
Julijana Ivanisevic1, Darlene Elias2,3, Hiroshi Deguchi2, Patricia M. Averell3, Michael Kurczy1, Caroline H. Johnson1, Ralf Tautenhahn1, Zhengjiang Zhu1, Jeramie Watrous4, Mohit Jain4, John Griffin2, Gary J. Patti5 & Gary Siuzdak1,6 The human circulatory system consists of arterial blood that delivers nutrients to tissues, and venous blood that removes the metabolic by-products. Although it is well established that arterial blood generally has higher concentrations of glucose and oxygen relative to venous blood, a comprehensive biochemical characterization of arteriovenous differences has not yet been reported. Here we apply cutting-edge, mass spectrometry-based metabolomic technologies to provide a global characterization of metabolites that vary in concentration between the arterial and venous blood of human patients. Global profiling of paired arterial and venous plasma from 20 healthy individuals, followed up by targeted analysis made it possible to measure subtle (
