Wyeth (International Summit speaker and recipient of an unrestricted grant for an ... weight and lower gestational age at delivery (20), but the only study conducted ...... critically for important intellectual content, and all authors approved the final ...
Association of Higher Rheumatoid Arthritis Disease Activity During Pregnancy With Lower Birth Weight Results of a National Prospective Study Yae¨l A. de Man,1 Johanna M. W. Hazes,1 Hugo van der Heide,1 Sten P. Willemsen,1 Christianne J. M. de Groot,2 Eric A. P. Steegers,1 and Radboud J. E. M. Dolhain1 with singleton pregnancies were available. Both the mean ⴞ SD birth weight (3,379 ⴞ 564 gm) and the mean ⴞ SD birth weight standard deviation score (SDS; ⴙ0.1 ⴞ 1.1), which is the birth weight adjusted for the gestational age and sex of the newborn, were comparable with those in the general population. On multiple linear regression analyses of birth weight and birth weight SDS, both of which were adjusted for covariates, only disease activity was associated with lower birth weight (P ⴝ 0.025). The gestational age at delivery was significantly lower in women who were taking prednisone (38.8 versus 39.9 weeks; P ⴝ 0.001), and their delivery was more often premature (
