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Ayahuasca Preparations and Serotonin Reuptake Inhibitors: A Potential Combination for Severe Adverse Interactions James C. Callaway & Charles S. Grob To cite this article: James C. Callaway & Charles S. Grob (1998) Ayahuasca Preparations and Serotonin Reuptake Inhibitors: A Potential Combination for Severe Adverse Interactions, Journal of Psychoactive Drugs, 30:4, 367-369, DOI: 10.1080/02791072.1998.10399712 To link to this article: http://dx.doi.org/10.1080/02791072.1998.10399712
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Ayahuasca Preparations and Serotonin Reuptake Inhibitors: A Potential Combination for Severe Adverse Interactions
James C. Callaway, Ph.D.* & Charles S. Grob, M.D.**
Abstract-The Amazonian psychoactive plant beverage ayahuasca has attracted increasing interest in recent years. Little attention has been given, however, to potentially dangerous interactions with
other drugs. In particular, the interaction between the potent monoamine oxidase-inhibiting harmala alkaloids in ayahuasca and the selective serotonin reuptake inhibitor (SSRI) class of antidepressants may induce a serotonin syndrome with potentially grave outcome. Caution is advised when combining ayahuasca with certain pharmaceutical drugs. Keywords-ayahuasca, drug interactions, harmala alkeloids, selective serotonin reuptake inhibitor (SSRI), serotonin syndrome
Ayahuasca (a Quechua word meaning "vine of the soul") is a psychoactive beverage that has been use
