Barry et al - PLOS

Barry et al. Figure S6 0003 0162 0163 0007 0139 0044 0002 0146 0155 0110 1619 0077 0200 0006 0156 0028 0178 0033 0100 0106 0204 0138 0001 1605 0012 0074 1620 0014 1608 0073 0060 0101 0066 0191 1617 1621 0058 0130 0229 0075 0132 0181 0187 1606 1622 1611 1887 0051 1613 0126 0004 0010 0067 0109 0153 0078 1616 0017 0068 0021 0102 0098 0228 0064 1610 0039 0085 0016 0174

-RSFADIGDIIRGKDLYLGNKK-QNQT----DR-----EKERLQQNLKEIFKKIHEKLEQ -RSFADIGDIVRGKDLFYGNP--QEKE----QR-----EK--LDEKLKEIFKIIHEKLEQ -RSFADIGDIVRGKDLFYGNP--QEKE----QR-----EK--LDEKLKEIFKKIHDNLVE ARSFADIGDIVRGKDLFYGNP--QEKE----QR-----EK--LDEKLKEIFKKIHDNLVE -RSFGDIGDIIRGKDLYR-----RDN-----KK-----DK--LENNLKTIFKKIHDNLVE ARSFADIGDIVRGKDLFYGNP--QEKE----QR-----EK--LDEKLKEIFKKIHDNLVE -RSFADIGDIIRGKDLYLGN---N------KEK-----EN--LEKNLRQIFKKIYDKLEN -RSFADIGDIIPRKRSCISV---IP-----KEK-----EN--LEKNLSQIFKKIYDKLEN -RSFADIGDIIRGKDLYLGN---N------KEK-----EN--LEKNLRQIFKKIYDKLEN -RSFADIGDIIRGKDLYLGN---N------KEK-----EN--LEKNLRQIFKKIYDKLEN ARSFADIGDIVRGKDLYLGN---N------KEK-----EN--LEKNLRQIFKKIYDKLDD ARSFADIGDIVRGKDLYLGN---N------KEK-----KE--LEENLKKIFKEIYDKLDG ARSFADIGDIVRGKDLYIGN---RKE----REK-----EQ--LQQNLKNIFAKIYEELKN -RSFADIGDIIRGKDLYRRD---NK-------K-----DK--LENNLKTIFKQIHEKLTD -RSFADMGDIIRGKDLYLGN---NKE------K-----EN--LEKNLRQIFKKIYDKLTD -RSFADIGDIIRGKDLYRRD---NK-------K-----DK--LENNLKTIFKQIHEKLTD -RSFADIGDIIRGKDLYRGN---RKKNETKTER-----EK--LEQKLKEIFKKIYDDVTS -RSFADIGDMVRGRDLYRG----NKKEK--KQR-----DD--LEENLKKIFGDIYNEVMR -RSFADIGDIIRGKDLYRG----NN------GK-----DK--LEENLKTIFGKIH-EGLK -RSFADIGDIIRGKDLYRGN---NGKD------------K--LRDNLKKIFKEIHDKLDK ARSFADIGDIIRGKDLFRGY---DQKDR--EQK-----KK--IQDNLKEIFKKIHDDVMK -RSFAGIGDIVRGKDLFRG----NKKEN--KQR-----DR--LEENLKTIFKQIHDDVTS ARSFADIGDIIRGRDLYGGN---NK------RR-----KQ--LDDNLKTIFTQIYEELLR ARSFADIGDIIRGRDLYSGN---KKE---KKQR-----EQ--LDDKLKKIFTQIYNDV-ARSFADIGDIVRGRDLYGGN---KKK------------EK--LEKNFKKYFQQIYNDVTR ARSFADIGDIVRGRDLYHGK---KKRGQTETER-----DK--LEENFKKYFQQIHSEVTR ARSFADIGDIVRGRDLYGGN---KKK------------EK--LEENFKKYFQQIHEELKR ARSFADIGDIIRGKDLYGRD---NKK----DKT-----DK--LQEQLKKYFNNIYDNL-ARSFADIGDIVRGRDLYRRD---NKK----DKT-----DK--LQEQLKKYFQKIYEGLTS ARSFADIGDIIRGKDLYGRN---NRK----RK-------Q--LEENLQKYFENIYYGLSARSFADIGDIVRGRDLYLGN---RKKKQTKTER-----EK--LDENLKRIFGKIHGGLDARSFADIGDIIRGRDLYIRN---KKK------------DK--LEENLQKIFAKIHGNLKARSFADIGDIIRGKDLYRRD---SRT------------DK--LEENLRKIFGIIYGKLKARSFADIGDIVRGRDLYRGD---NR------EK-----TK--LEKNLKTIFEKIYNNLNARSFADIGDIVRGKDLYLGK---KKRGQ--TER-----DK--LESNLKKIFGKIHEGLSARSFADIGDIVRGRDLFRGD---NR------EK-----KK--LEKNLQNIFKKIQEKL-ARSFADIGDIVRGKDLYLGD---NG-------K-----DR--LEENLRKIFKEIHGGLSR -RSFADIGDIVRGKDLYLGD---NG-------K-----DR--LEENLKRIFKEIYDKLDARSFADIGDIIRGKDLYRGN---NG-------K-----DK---QDNLKKIFKEIYDKLNARSFADIGDIIRGKDLYRRD---NG-------K-----DR--LEENLKTIFKKIYDNLME -RSFADIGDIIRGKDLYIRN---KK-------K-----DK--LQEQLKKYFQIIYDKL--RSFADIGDIVRGKDLFIGN---NK-------R-----DK--LEKQLQKYFKQIYDKLDG -RSFADTGDIIRGKDLYIGN---KKE------R-----AR--LEENLKKIFKKIYEELLI ARSFADIGDIIRGKDLYLGNPQEKEK------R-----EK--LDDNLRKIFGNIYDKLLE ARSFADIGDIIRGKDLYLGNPQEKEK------R-----EK--LDDNLRKIFGNIYDKLLE ARSFADIGDIVRGKDIFIGN----KK------K-----DK--LDENLKRIFGKIYEKLDARSFADIGDIVRGRDLYGRD----NK------K-----DK--LQEQLKQYFNNIYDNLEG ARSFADIGDIIRGRDLYSG----NKKE----KKQR---EQ--LDDKLKEIFENIQKEN-ARSFADIGDIIRGRDLYSG----NKKE----KKQ----EQ--LDDKLKEIFENIQKEN--RSFADIGDIIRGRDLYLG----NKK-----KKN-----Q--LEERLKTMFENI-KEN-ARSFADIGDIVRGRDIFRG----NDEK----KKR----DE--LDDKLKDIFQNIKKEN-ARSFADIGDIIRGKDLYLG----NPQE----KEKR---KQ--LDKKLKEIFENIK-KS-ARSFADIGDIIRGKDLFYG----NPQE----KEKR---KQ--LDDNLKTIFGKIKGNN--RSFADIGDIIRGRDLYSG----NSKE----KNRR---KK--LEDNLIEIFKMIQGKN--RSFADIGDIIRGRDLYRG----NTKE----KKKR---DE--LEKNLEIIFQNIQNKN-ARSFADIGDIVRGRDLYRG----NKKE----NKQR---EK--LEENLRKIFENIYEGLSN ARSFADIGDIVRGRDLYRGG---NTKE----KEKR---KQ--LEENLRKIFENIYEEL-ARSFADIGDIIRGRDLYRG----NSKE----K------DY--LQDKLKKYFQKIYDNLNARSFADIGDIVRGRDLYSG----NKKE----KKQ---RED--LENKLKEVFGKIHSEVMK ARSFADIGDIVRGRDLFYG----NPQE----KEK---RDE--LESKLKEIFGKIHGGLSK ARSFADIGDIVRGRDLFYG----NPQE----KEK---REK--LDENLRKIFKKIYDNLNARSFADIGDIVRGKDLYLG----DKG-----NDK--------LEKNLKRIFGKIHGGLST ARSFADIGDIIRGKDLYLG----NKKK----NEKDREKEK--LENKLKEYFEKIYNSLES -RSFADIGDIVRGRDLYLG----KKKKKQNGKETETERDQ--LEEKLQSFFKNIHDKLDD ARSFADIGDIVRGKDLYLG----KKKK-QYGKETETERDQ--LENKLKEIFGKIHGNLRN ARSFADIGDIVRGKDLYLG----KKKKKQNGKKTETERDQ--LESKLKDIFAKIHSEVTN ARSFADIGDIVRGKDLYLG----KKKK---KTETERERDQ--LEQKLKGIFKKIYEGLTG ARSFADIGDIVRGKDLYLGY---NRKE----KAQK---EK--LENKLKEYFENIHDKLEARSFADIGDIIRGKDLYLGY---NRKE----KAQK---EK--LEQNLKKFFQNIDEKLP-

0024 0168 0046 0083 0061 0043 0177 1609 0202 0056 0089 0059 0081 0013 0193 0203 0063 0198 0048 1676 0015 0149 0127 0148 0042 0023 0208 0020 0091 0170 0131 0169 1764 0215 0226 0221 0019 0223 0227 0040 0201 0071 0052 0072 0079 0031 0179 0134 0147 0133 0137 0057 0032 0107 0008 0196 0129 0053 0080 0099 0152 0005 0026 0151 0180 0054 1886 1618 1612 0011 0037

-RSFADIGDIVRGRDLYLGN---TQEK----KQRK---Q---LESKLKEIFGKIHEEV-ARSFADIGDIVRGIDLYGGN---N-------KRRK---Q---LDDKLKEIFKKIHENLG-RSFADIGDIIRGRD-YGGS---KKEK----EKRE---Q---LDDKLKDIFKKIHGG--ARSFADIGDIIRGKDLFYGN---PQEK----EKRD---E---LENKLKDIFAKIHNGLD-RSFADIGDIVRGKDLYSGN---KKEN----KQRE---K---LDKKLKDIFGKIHGN--ARSFADIGDIVRGKDLYLG----DKGE----KK------K--LEEKLKQYFKNI-EELKN -RSFADMGDIVRGRDLYLGY---DDKE----KDRR---DK--LEKSLKTIFGNIYEELKN ARSFADIGDIVRGKDLYLG----DKGE----KK---------LEEKLKTIFKQIYDKLTH ARSFADIGDIVRGRDLFYG----NTYE----SARR---EQ--LEKNLQNIFKQIHDKLVK ARSFADIGDIIRGKDLFIGY---NQKD----RKEK---AK--LQENLRKIFKDIHNNLQARSFADIGDIVRGKDLFIGY---NQKD----RKEK---EQ--LQNKLKYIFKKIHEKL-ARSFADIGDIIRGKDLYLGD---KKKD----QQEK---VR--LEENLKKIFGHIYEELLI ARSFADIGDIIRGKDLYLGG---RGRD----Q----------LESNLRKIFAKIHDKLYARSFADIGDIVRGRDLYLG----NPQEIK--QR-----QQ--LENNLKTIFGKIYEKLNARSFADIGDIVRGRDLYSG----NDEEKK--QR-----KQ--LDKKLKVIFGKIYKDLTK ARSFADIGDIVRGKDLYLGY---DDKEKK--RR-----EK--LEQKLKEIFAKIHEELKN -RSFADIGDIIRGKDLY-G------GNNK--RR-----QQ--LEENLKTIFGHIYEELKK -RSFADIGDIIRGKDLY-G------GNNK--RR-----QQ--LEENLKTIFGHIYEELKK ARSFADIGDIIRGKDLY-R------GVN---GN-----DK--LEDNLKKIFGIIYEELKK ARSFADIGDIVRGRDLYRG------GNNK--RR-----QQ--LDDKLKKIFGKIHDEVTR ARSFADIGDIIRGKDLYRG----NK-EKD--RR-----RK--LEENLKTIFGDIYKELSR -RSFADTGDIVRGRDLYRG----NKQEKE--KR-----KK--LQQNLKTIFGKIHEGLSE -RSFADIGDIVRGRDLYSG----NKK------K-----ER--LDENLKTIFKNIYEKLLE -RSFADIGDIVRGRDLYRG----NNKERN--RR-----DQ--LESKLKDIFKNIYKDVTS ARSFADIGDIIRGKDLYSR----DNR------K-----DK--LQTKLKEYFKKIYYGLTD -RSFADIGDIIRGRDLYSG----NKVK-----K-----KK--LDDSLKTIFGKIYEGLTG ARSFADIGDIVRGKDLYSG----NNKEKN--RR-----QQ--LEQKLKDIFKKIYEELKD ARSFADIGDIVRGKDLYRGY---DDEEKK--KR-----ED--LEKNLKEIFKEIHGGLTARSFADIGDIIRGKDLYVG----NRKEKE--K------EK--LQKNLKNIFAKIHSGLTARSFADIGDIIRGKDLYLG----DIKKKQ--NGKKTEREK--LEENLKRIFGKIHEDVTN -RSFADIGDIVRGRDLFYG----NDEEKK--QR-----DK--LDENLKEIFKKIHSEVTS ARSFADIGDIVRGKDPFYG----NTYEST--QR-----EK--LEKNLKDIFGKIHDDVTS ARSFADIGDIVRGKDPFYG----NTHESA--QR-----KV--LDKKLKEVFGKIHDDVTS ARSFADIGDIIRGKDLFYG----NTQESA--QG-----KK--LDDKLKEIFKEIHDEVTK ARSFADIGDIVRGKDPFYG----NTYESA--RR-----EK--LEENFKKYFQQIHDDVTK -RSFADIGDIVRGKDLYLG----NPQESA--RR-----DK--LENKLKEIFKEIHSEVTK ARSFADIGDIVRGRDLY----LRDKGK---RDK---------LEEKLKTIFGIIYGKLKN ARSFADIGDIVRGRDLYGGS-KKEKDR---RDQ---------LESKLKDIFGKIYQELTT ARSFADIGDIVRGRDLY----RGNDEE---KKK---------LEKKLKKIFGIIYDNLVQ ARSFADIGDIIRGKDLYRGNNGKDKAQ---KLK---------LQDNLKEIFQKIQ----ARSFADIGGIVRGRDLYR----RDKGE---ETK---------LENKLKDIFKMIQ----ARSFADIGDIVRGKDLYR----RDKGE---ETK---------LEKNLKEIFRRIQ----ARSFADIGDIVRGRDLYR----RDKGE---ETK---------LEKNLKTIFGKIHK---E ARSFADIGDIVRGKDLFL----GNSVE---SAQR----II--LEKNLKGVFGNIYNELTT ARSFADIGDIIRGRDLYR----RDKGE---ETK---------LEKNLKEIFKNIYNELTT -RSFADIGDIVRGRDLYLG----NPQE---SAQR----KQ--LDENLKTIFKNIYEKLLE -RSFADIGDIIRGKDLYLG----NDKE---KDQR----KV--LDENLKTIFKNIYEKLLQ -RSFADIGDIIRGRDLFYG----NTQE---STQR----KQ--LDDKLKDIFGNIYEGL-K -RSFADIGDIVRGKDLFLG----NTYE---SAQR----KV--LDEKLKEIFKNIR----K -RSFADIGDIIRGKDLYLG----NPQE---IAQR----KE--LDKKLKDIFAKIYEE-LK -RSFADIGDIVRGKDLFLG----NSVE---SAQR----KV--LDENLKKIFKQIHEK-LD ARSFADIGDIVRGKDLFLG----NDKE---KEKR----KQ--LDENLKTIFKNIYEKLLE -RSFADIGDIVRGRDLYR-----RDSR---TD-------K--LEENLKVIFGNIYKELTS -RSFADIGDIVRGKDLFLG----NDKE---KDQR----KK--LEKNLKTIFGNIYKELK-RSFADIGDIIRGKDLFIGYNEKDRKE-----K-----EK--VQKNLKKIFRKIYEELKG -RSFADIGDIIRGKDLFIGYNEKDRKE-----K-----EK--VQKNLKKIFRKIYEELKG -RSFADIGDIIRGKDLYLGYDDKEKKR-----R-----EK--LENKLKVIFGHIYEELTT ARSFADIGDIIRGKDLFIGYNQKDREQ-----K-----KK--IQDNLKDIFGKIYKELTT ARSFADIGDIVRGRDLFIGYDKKDREQ-----K-----KK--IQDNLKEIFKKIYDEVTR ARSFADIGDIVRGKDLFLGNDE-EKKK-----R-----DE--LEENLQKIFAKIHSGLTS -RSFADSGDIVRGKDLFLGNDE-EKKK-----R-----KQ--LQQNLKNIFGKIHSDVMK -RSFADIGDIIRGKDLFLGG---PDQ-----EK-----KK--LEENLRNIFKNIHDHLT-RSFADIGDIIRGKDHYLGN----NQ-----EK-----EK--LQENLRQIFQNIMDKNE-RSFADIGDIIRGKDLYLGY---NKK-----EKAQK--EK--LEQNLNFFFQNIDDK-L-RSFADIGDIIRGKDLYRGG---NTK-----EKRQR--QK--IEDNLKEIFKNIKN--TARSFADIADIVRGKDLFLGG---PNQ-----EK-----KL--LEEKFKKYFQTLYNN-LARSFADIADIVRGKDLFLGH---SK------EK-----EK--LEQNLKNLFKQLYEKLNARSFADIGDIVRGKDLYLGT---NE------EK-----KP--LEENLKKLFKKLYTDLKARSFADIGDIVRGKDLFLGH---SK------EK-----EK--LEQNLKNLFKQLYEELKK ARSFADIGDIIRGKDLYRGN---NK------EK-----DR--LEDNLKKIFKQLYEELTK ARSFADIGDIIRGKDLYLGN---KKHNEAEREK-----EK--LQRNLKYIFKKIYDNLS-

0049 0027 0034 0069 0055 0104 0030 0160 0022 0171 0041 1607 0216 0082 0076 0214 0047 0141 0197 0065 1614 0036 0084 0143 0029 0038 0218 0050 0224 0070 0190 0194 0173 0167 1615

ARSFADIGDIIRGKDLYRGN---KKYNETEREK-----EK--LQRNLKYIFKKIYDNLV-RSFADIGDIIRGKDLYLGN---KKRNENLREK-----EK--LEIKLKSFFKNIYNNLT-RSFADIGDIIRGKDLYRGD----EKK-----------EK--LELKLKSFFKNIYDDLIN ARSFADIGDIIRGRDLYRGK---RQEK-----------DY--LQEKLKNYFQKIYDDLAK ARSFADIGDIVRGRDLYRGN---NREN-----------DK--LEKKLKEYFKKIYEQLVK -RSFADIGDIIRGKDLYRGN---NGK------------DK--LEENLKTIFKKIHGGLTG -RSLADIGDIVRGRDMFRSN------------------EN--VEKGLRVVFKNIHENLRG -RSFADIGDIVRGRDMFRSN------------------EN--VEKGLRAVFKNIRENLRG -RSFADIGDIVRGRDMFKSN------------------EK--VEYGLRKLFKKIHENLRG -RSFADIGDIIRGKDLYLGN---NKE------K-----EN--LEKNLRQIFKKIYDKLEN ARSFADIGDIVRGRDMFKSN------------------ED--VEKGLKVVFKKIQRKLNV ARSFADIGDIVRGKDMFKSN------------------EK--VEYGLRKLFKKIH-DLNK ARSFADIGDIVRGRDMFKSN------------------EK--VEIGLKKVFEKINNGLKK ARSFADIGDIVRGIDMFKSN------------------DK--VEKGLREVFKNIYEGLKG ARSFADIGDIVRGKDMFKPN---DK-------------DE--VWKSLRAVFKKINDNLKE ARSFADIGDIVRGIDMFKPN---VH-------------DK--VEKGLREVFKKIHDEMEG -RSFAD-GDIVRGKDMFKRT---DN-----------------VEKGLRAVFGKIYKSLTF -RSFADIGDIVRGRDMFKRT---DK-------------DY--VENGLREVFNNIYGQLEN -RSFADIGDIVRGKDMFKSN---KN-----------------VEIGLKKVFNKIYDKLKQ -RSFADIGDIVRGRDMFKPN---P--------Q-----DK--VQEGLKNVFKNIHENFPARSFADIGDIVRGRDLYRGN---NG-------K-----DK--LENNLKEIFKKIYEELIK ARSFADIGDIIRGKDLFIGY---NQKDRK--EK-----EQ--LQNSLKIIFREIYNKLHN ARSFADIGDIVRGKDLFNGY---NQEDIK--EK-----AK--LQENLRKIFAKIYNNLEN -RSFADIGDIIRGKDLFRGY---NEID-E--QK-----KK--IQDNLKDIFAKIYNSLKD -RSFADIGDIIRGKDLFLGH---KQ------RK-----KE--LEENLRKIFANIYKELTS ARSFADIGDIIRGKDLFLGN---NDNDKI--KK-----EK--LQGNLEKIFKRFKA--KY ARSFADIGDIIRGRDMFLGN---NEKDMR--EK-----QK--LQSNLKKIFEKIRN--DG ARSFADIGDIIRGKDLFLGH---KQG------K-----EH--LEKRLESMFKNIQN--EN ARSFADIGDIIRGKDLYRRD---KGG------K-----TK--LEKNLEKIFQYIKE--NN ARSFADIGDIIRGKDLFLGH---QQK------K-----SV--LEASLKSMFENIK---KN ARSFADIGDIIRGKDLFLGH---KQR------K-----KY--LEESLKSMFDNIK---KN ARSFADIGDIIRGKDLYLGH---EQG------N-----NR--LEARLKTIFQNIQN--KN ARSFADIGDIVRGKDLFLGH---QQR------K-----RK--LEENLKQMFENIK---KN ARSFADIGDIIRGKDLYLGY---DQKEKE--QR-----DK--LEEKLQKIFQQIHSDVTS ARSFADIGDIIRGKDLYRG----NTKEKK--KR-----ED--LENKLKEIFAKIHSDVTS **:.. ..:: : * :

0003 0162 0163 0007 0139 0044 0002 0146 0155 0110 1619 0077 0200 0006 0156 0028 0178 0033 0100 0106 0204 0138 0001 1605 0012 0074 1620 0014 1608 0073 0060 0101 0066 0191

P------------AKERYEGD---EANN--FF-KLREDWWNANRQQIWKAITCNVP---P------------AKERYEGD---EANN--FF-KLREDWWNANRQQIWKAITCNVP---KKGN--------EAKDRYKDE---PDNN--FY-QLREDWWMANRDQVWKAITCNVP---KKGN--------EAKDRYKDE---PDNN--FY-QLREDWWMANRDQVWKAITCKAD---KKGN--------EAKDRYKDE---PDNN--FY-QLREDWWMANRDQVWKAITCKAD---KKGN--------EAKDRYKDE---PDNN--FY-QLREDWWMANRDQVWKAITCKAD---E--EAK---------EYYKN--NDDTEN--YY-KLRNAWWEANRQEIWKAITCSAA---E--EAK---------EYYKN--NDDPEN--YY-KLRNAWWEANRQEIWKAITCSPA---E--EAK---------EYSKN--NDDPEN--YY-KLRNPWWEPNRQEIWKPIACSAA---E--EAK---------EYYKN--NDDTEN--YY-KLRNAWWEANRQEIWKAITCSAA---A--VIQ---------KHY----DDAKGN--YY-KLRNDWWEANRQEIWKAITCGAG---K--NGK---------KTLQERYKDDKEN--FF-QLREDWWALNRQDVWKAITCEHP---G--KTN---------GIEER-YNDDTTD--FF-KLREDWWALNRQQVWYAITCGAA---L--RAN---------DHYKD---ENGGN--FF-KLREDWWTANRATVWEAITCRYP---L--RAN---------DHYKD---ENGGN--FF-KLREDWWTANRATVWEAITCRYP---L--RAN---------DHYKD---ENGGN--FF-KLREDWWTANRATVWEAITCRYP---TSGRTNGK----TLQARYEG---DEANN--FF-KLREDWWTANRHTVWKAITCDVV---GR-NVKTN----GIEERYGN-----DPN--FF-QLREDWWTANRAKVWEALTCDAPH-----NGKTN----GIEERYGN-----DPD--FF-QLREDWWTANRETVWKAIRCSAPR----------------KDRYND----DTPD--FL-KLREDWWDANRHTVWKAITCGAPH--T--SGRTKGA-EELKARYKDR---KDPD--FF-KLREDWWNANRETVWKAITCGAG---T--SGKNR---LALQERYKED---PDKN--YS-KLREDWWNANRQEVWKAITCGTHD-----TSTNVEA---LKTRYK--D--TTN---YY-ELREDWWEANRAKVWYAITCDA-------TKTNGE----LKRRYK--D--TDN---YY-ELREDWWDENRHTVWEAMTCDAR---TSTSGNNKDT---LQERYKE-D--PNNN--YF-QLREDWWTANRHTVWEALTCEVG-------GSNWQA---LQKRYKG-D--KENY--FF-QLREDWWTANRATIWEALTCEAP-------GDKTKE---AEKHYQ--D--TTN---YS-KLREDWWTANRHTVWKALTCDDR------EG----A---AKKHYNG----DKNN--FF-KLREDWWYANRQQVWKAITCKA----T--NGRNGEA---AKKHYED----GAPD--FL-KLREDWWEENREKIWKAITCKA-------NETNAKE---LQERYKD----DTPD--FF-KLREDWWSLNRETVWKAMTCSAD---------DK-----IKSNYDD----SEGN--FY-QLREDWWALNRQDVWKAITCSAA---------D------ARTHYSD----TDKN--YY-QLREDWWTANRATIWEAITCEAG---------D------AQSHYSD----TT-N--FY-QLREDWWALNRKEVWKAITCEAG---------NPK----AKTHYEDKD--PEKN--FF-KLREDWWTANRHTVWKAITCGAY----

1617 1621 0058 0130 0229 0075 0132 0181 0187 1606 1622 1611 1887 0051 1613 0126 0004 0010 0067 0109 0153 0078 1616 0017 0068 0021 0102 0098 0228 0064 1610 0039 0085 0016 0174 0024 0168 0046 0083 0061 0043 0177 1609 0202 0056 0089 0059 0081 0013 0193 0203 0063 0198 0048 1676 0015 0149 0127 0148 0042 0023 0208 0020 0091 0170 0131 0169 1764 0215 0226 0221

------TKNG---AQNYYEDKD--TDKK--FF-KLREDWWTANRHTVWKAITCGAY---------TGD----AQTHYED----ATEN--FY-QLREDWWALNRVQVWNAMICGVE---A--NGKKGQK--PAKEYYK-DE--NGGN--YF-QLREDWWTANRATVWYAITCGAG-------GNKG-K--EAKKHYQ-DT--K--N--YY-QLREDWWYANRKMVWYAITCGAE-------GKNGKK--TLQKRYQ-DD--GTGN--YY-QLREDWWNNNRIMVWHAITCGAA---D--LKKDPTKSAEAQKRYKKDE--E--N--YY-QLREDWWTANRSTIWEAITCDAK-------KDKEG----AKERYK-D---TA-N--YY-ELREDWWALNRQDVWKAITCEAG-------KKKEE----AKARYN-DE--SG-N--YF-QLREDWWNNNRKMVWYAITCHAG---S--TSDKNGE---LQKRYN-DE--SG-N--YY-LLREDWWNINRKKVWDAITCEAQ---E--NRTNGRNGEAAKKRYEGD-----DN--YY-QLREDWWTANRETVWKAITCDAP---E--NRTNGRNGEAAKKRYEGD-----DN--YY-QLREDWWTANRETVWKAITCNVS----------------KKDRYNGD---G-DN--YY-QLREDWWTANRATVWKAITCEAP----------------VQNHYNGDK--N-NN--YY-QLREDWWTANRETVWEAITCDAP-----------------NSNLKSL---TDD------QIREYWWALNRQEIWKAITC----DAP --------------NSNLKSL---TDD------QIREYWWEANRKEVWKAITC----DAP --------------NGELKKL---LTE------QIREYWWALNRKEVWKALTCS---DKL --------------NSKLTNL---NDD------QIREYWWDANRHTVWEAITC----NAG --------------DTKLSTL---EDE------EIREYWWALNRLEVWKAITC----HVV --------------KSKLGQL---KLD------KVREYWWNANRAKVWEAITC----KAK --------------ESKLGAL---SLD------QVREYWWELNRETVWKAMTCS---DRL --------------ED-LKSL---SLD------EVREYWWDANRATVWKAITCD---NKL N-----------GVKARYEGD---KEN---FY-QLREDWWALNRDQVWKALTCS---DDL K-----------GAKTRYEGD---KNNN--FF-KLREDWWALNRDQVWKALTCD---DRL ------------GAQTYYNDN--DKDKN--YY-QLREDWWIANRDQVWKAMTCSDDDKKL T-----------SGRTNGTEERYGKDPD--FY-QLREDWWTVNRDQVWKAMTCSDDDKKL K-----------DAQNYYKDD---AKKN--FY-RLREDWWTANRHTVWKAITC-DEENKL ------------GAQTHYSDT---T--N--FY-QLREDWWNANRATIWEAITC-NDDNKL KN----------GAQKHYQDE---NGGN--FF-KLREDWWEANRKDVWKALTC-SD--KL S------------IKSQYDDE---AN-N--FF-QLREDWWEANRKEVWKALTC-DDDKKL S------------IKSNYN-D----APY--YY-KLREDWWTANRETVWEAMTCS---KEL G------------VKARYIGD----TTD--FF-KLREDWWNANRETVWKAMTCS---KEL GR----NGK-NREIEKRYEGD----D-N--YY-QLREDWWNANRETVWKALTCNED-KKL G------------VKDHYQ-D----TDN--YY-ELREDWWALNRDQVWKAITCK-----A -----------QRAKEHYIKD--KETGN--YY-KLREDWWTANRHTVWEALTCEVG--------------LKAKNYYTKE--KDP-N--FL-KLREDWWTANRETVWEALTCDA---------------TRGKKGAQTRY-NDTDN--YF-QLREDWWALNRDQVWKAITCEA---------------THEKKHYE----NDTAN--YY-KLREAWWALNRQDVWKALTCDA---------------SKEKISHYNG---DTPY--YY-KLREDWWTANRHTVWEALTC-----KA -----------GKTLQKRYNG---DDPN--YY-KLREDWWTANRATIWEALTCDED-NKL -----------LKDARTHYS----DTTN--YY-KLREDWWTANRSTVWEAITCG----AP GK----TNG---EIEARYGNDPK-G--D--FF-QLREDWWNANRETVWEAITCSDK---L GK----TNGKNGEIETRYKGDAK-K--N--FY-QLREDWWEANRQEVWKAITCSEK---L ------------DAQTHYKKDDK-GSEN--YY-QLREDWWDANRETVWKAITCSEK---L DN----E-----KAKDRYNGDG--G--N--FF-KLREDWWDANRETVWKAITCSED---L ----------DTEAQKRYKNNDE----N--YF-QLREDWWTANRATIWEAITCDED-KKL ----------DSEAQTRYNDATG----N--FY-QLREDWWTANRATIWEAMTCSED---L ST----SG--RNGVKDHYQDENG-G--N--FF-QLREDWWTANRATIWEAITCDEE-NKL -----------NSIKSNYNDAP-----N--FF-QLREDWWTANRATIWEALTCDA---------GA----EA---RYGND----PE---FF-KLREDWWTANRETVWKAITCN-----KKGKKGA----EELQKRYGSD----EN---YY-QLREDWWTANRETVWKAITCN---------GKK----SALQERYTND---GPE---FF-QLREDWWNANRQEIWKAITCNDDNK-D-RKNGA----EELQKRYNGD---EANN--FF-QLREDWWTANRNDVWKAITCSADK--D-RKNGA----EELQKRYNGD---EANN--FY-QLREDWWMANRDQVWKAITCKADN--D-PTK------SELQARYNGD---GPE---FF-KLREDWWYINRKDVWKAIRCSAPK--R-KQNG-----QALQARYQDE---NGGN--FF-KLREDWWTANRNDVWKAITCDDDNK-TNGE---------IEARYK-D---AKNN--FY-QLREDWWTANRHTVWKAITCNA-W--S------------AKEHYKGD---KENY--FF-QLREDWWTANRSTVWKAITCKADT--DN-KTNGKK--LALQKRYQDE---IGGN--FF-KLRDDWWTANRETVWKAITCSADR--TNGKTNG------AEARYNDD---TG-N--YY-KLREDWWTANRATVWKAITCSEDL--QK-----------AKQHYNGD---GD-N--YY-KLREDWWTANRETVWKAMTCSDDL--GV------------KERYTND---GG-D--FF-QLREDWWTAN-ETVWKAMTCSEHL--A-------------KDRYKND---TE-N--YY-KLREDWWTANRATVWKAITCNA--------KNG------AQNYYKDK---NGDN--FF-KLREDWWDANRATVWKAMTCSEKL------KKG------AEARYKD----NDEN--YY-QLREDWWEANRAKVWEAMTCS--V--GK--KEV------LKTRYKDI---NDPE--FF-KLREDWWTANRATVWKAITCHAGE--GSNGK--------LKKRYKDD---DKKN--FY-RLREDWWTANRHTVWKAITCDAKA--NSSNKDA------LKTRYKDD---DTEN--YF-QLREDWWTANRETVWKAMTCKADT--G------------AQTRYKKD---G-GN--YF-QLREDWWTANRETVWYAITCGAGT--GRS-ASP------LQARYQGD---DNNN--YS-KLRKDWWTANRETVWKALTCDAPG--GGTNGQT------LQERYKGD---DNNN--YS-KLREDWWTANRETVWKALTCDV----GQT----------LKTRY-GS---DAPD--FF-KLREDWWDANRATIWKAITCDAK----

0019 0223 0227 0040 0201 0071 0052 0072 0079 0031 0179 0134 0147 0133 0137 0057 0032 0107 0008 0196 0129 0053 0080 0099 0152 0005 0026 0151 0180 0054 1886 1618 1612 0011 0037 0049 0027 0034 0069 0055 0104 0030 0160 0022 0171 0041 1607 0216 0082 0076 0214 0047 0141 0197 0065 1614 0036 0084 0143 0029 0038 0218 0050 0224 0070 0190 0194 0173 0167 1615

GKTNGQK-----SAKEYYEDK---DTDK-NYY-KLREDWWALNRQQVWKAITCNAG----TTNGKK-----SAKEYYKD----DTDG-NYY-KLREDWWNANRQDVWKAITCNAR------N-KK-----DAKSRYND----DTK--NYF-QLREDWWALNRDQVWKAITCNAG----RKNQS------KLSQLT-------LD------QVREYWWEENREKVWKAITCNA-----GKNQS------KLSQLT-------LD------QVREYWWERNREKVWKAITCNA-----GKYP-------KLNGLP-------LD------KVREYWWDANRLDVWKAITCDAP---VTKGSNG-----KLKARYG------SDKENYY-QLREDWWEENRETVWKAITCNA----SGKNVD------KAKERYKG----DADNN-YF-QLREDWWEENRETVWKAITCD-V-----KN--------GTKERYN-----DTDN--YF-QLREDWWEENRETVWKAITCHVV---DNKTNG-------AEARYKDD---GG-D--FF-QLREDWWNANRKEIWKAITCHAR---DNKTSGKK---EEIERRYKGD---AKKN--FY-QLREDWWTANRHTVWKAITCDAR---NGKTNGK----NVDTLKDRYE---GDDN--YY-QLREDWWALNRDQVWKAITCEAG---N----------NYSTLNDLS----------LE-QVREYWWALNRETVWKALTCDAG---NGKN-GKN-A-EELKARYQDE---NGGN--YY-QLREDWWDANREKVWKAITCNAG---S-----------EAQKHYKDD---NGGN--YY-QLREDWWDANRETVWKAITCNAG---DNKTSGKNGA-EELQKRYKKD---EDPN--YY-KLREDWWEANRETVWKAITCDAG---TNGKNGK----KDAEERYKGD---EANN--FF-KLREDWWTENRETVWKAITCDAH---KDRKNGE----EELQKRYKKD---EDKN--FF-KLREDWWEENRQQVWKALTCDAH---AQTYYED--------K--DT----DK---NFF-QLREDWWTENRGTVWKAITCDAH---AQTYYED--------K--DT----DK---NFF-QLREDWWNANRKEVWKAITCKAN---SREKSAEA------QKRYGS----DAP--YYF-QLREDWWALNSQDVWKAITCEAK---TNG-KNGKNA-EELKARYED----ESG--NYF-QLREDWWDANRKKVWDAITCKAN-----G-KNG-----EIETRYGS----DE---NYF-QLREDWWDANRAKVWYAITCGAG---TRGKQNG-----ELQKRYKG----DAKK-NFY-QLREDWWDANRHTVWEAITCGAG---TSG-SNG-----QIEARYGS----DAP--YYY-QLREDWWTVNRDQVWKAITCKAN---DAKA----------KSYYKND-----NDRNYF-KLRNDWWELNRQQVWNAITCGAP---DLKD----------LTL---D-----QVREY-------WWALNRQDVWKAITCNAP---DPEA----------KNYYAKE-----KDPDFL-KLREDWWELNRQDIWKALTCNAP---NPRL----------TDL---------TD-D---QIREYWWKANREKVWKALICHAP---TGEA----------RDHY--N-----NDYPYFYQLREDWWNANRYDVWKAITCNA----DPQ-----------KSSYNDD-----GTGNYY-KLRNDWWELNRQEIWKAIICQAP---DPK-----------KSSYNDD-----GTGNYF-KLRNDWWELNRQEIWKAIICQAP---NNKNEA-------IKTHYEKD-----GQ-NYY-KLRNDWWELNRQEIWKAITCDAP---NNKNEA-------IKTHYQDD-----DP-NYY-KLRNAWWEANRQEVWKAITCGA----DPK----------ARDHYNDA-----GE-NYY-KLREDWWNANRLDVWKAITCN-D---KNKED--------ATGHYGGD------E-NYY-KLREDWWDANRQEIWKAITCSAD---EE-----------AKQTYQDN-----DE-NYY-KLREDWWDANRETVWEAITCN-A---DQG------KKDAAIKHYFDP----KGN--YY-QLREDWWDLNRHDVWKAITCSAP---DK-------NGEVAKEYYISD----APN--YY-RLREDWWDLNRHDVWKAITCDAP---KY--------KEKAETDYKDD----TKN--YS-KLREDWWELNREKVWNAITCYAH---GV--------TDR----YKD-----TVN--YY-QLREDWWEANRETIWRALTCDAP----------------PAKSHYED---GDKSGNYY-KLREHWWIVNRKQLWEAITCIAP----------------PAKNYYAD---DDGSGNYY-KLREHWWIVNRKQLWEAITCIAP----------------PAKSHYED---GDKSGNYY-KLREHWWIVNRKQLWEAITCIAP---E------------EAKEYYKN---NDDTENYY-KLREHWWIVNRKQLWEAITCIAP----------------AAKS-YYN---ADEKGNYY-KLREDWWTVNRDQVWKAITCKAP----------------SKIN-DYD---GDGP-EYY-KLREAWWTANRDQVWKALTCSAP----------------IGIH-DYD----DISGNYY-KLRDAWWTVNRNQVWEAITYKAP----------------EGVKVHYK---ENKDGNYY-KLREDWWTANRDKVWKALTCNAP----------------KGIH-DYD----DKYGNYF-KLREAWWNANRDKVWEAITCNAP----------------EVKN-YYN---PDGSGNYY-KLREAWWDVNRNKVWEAITCGAL----------------PAKNYYAD---HDKSGNYY-KLREDWWTVNRDQVWKALTCTAP----------------NAKAYYSD---KDKSGNYY-KLREAWWNANRDQVWRAITCKAP----------------PAKSYY-N---ADGEGNFY-KLREDWWTANRDQVWKAITCEAP------------E---PLKRHYAD---HDKSGNYY-KLREDWWTANRDQVWKALTCSAD---NGSN----GK---EAQEYYKK---DDKDPNYY-KLREDWWTANRDQVWKALTCSAD---TE-----------AKRHYNDE---DDNEGNYF-QLREDWWDANRKEVWKAITCSAG---TE-----------TKKRYNEE---DDNEENYY-KLREDWWALNRQEVWKAITCGAG---KKG----------AETRYG-------SDENYF-QLREDWWDANRKEVWTAITCDAG---TSDKNGKNGQ---IEARYG------SDTKNYF-QLREDWWALNRDQVWKAITCAAK---ED-----------------------INNLPID-DIREYWWALNRNDVWKAITCSAP---RT-----------------------PKNVPIG-QVREYWWALNREDVWKALTCSAD---KD-----------------------LTTIPLE-KFREYWWALNRKEVWKAITCDAG---KSS----------------------LESLTDE-EIREYWWALNRDQVWKAITCNAP---NEK----------------------LNSLQNE-QVREYWWALNRDQVWKAITCAAD---NEK----------------------LNSLENE-QVREYWWEANRNQVWKAITCGAT---KSP----------------------LDKLSVD-KVREYWWALNRDQVWNAITCGAG---NDK----------------------LDKISIE-QVREYWWNANRDQVWEAITCHAA---T--N-GKLK------TRYED-----NDE-NYF-QLREDWWNANRKEVWKAITCKAP---TSGNKGKMNG---AEARYKD-----DGSGNFY-RLREDWWEANRETVWKALTCNAP---** * :* .:

0003 0162 0163 0007 0139 0044 0002 0146 0155 0110 1619 0077 0200 0006 0156 0028 0178 0033 0100 0106 0204 0138 0001 1605 0012 0074 1620 0014 1608 0073 0060 0101 0066 0191 1617 1621 0058 0130 0229 0075 0132 0181 0187 1606 1622 1611 1887 0051 1613 0126 0004 0010 0067 0109 0153 0078 1616 0017 0068 0021 0102 0098 0228 0064 1610 0039 0085 0016 0174 0024

-EDAKYLEKK-DGRAYG---CTHTS---------CHCA-------VGD-----------V -EDAKYLEKK-DGRAYG---CTHTS---------CHCA-------VGD-----------V -EDAKYLEKK-DGRAYG---CTHTS---------CHCA-------VGD-----------V -NSNRYFRQT-CGSGEK---GSATTG-------KCRCSDKPKSGKPGDVS--------IV -NSNRYFRQT-CGSGEK---GSATTG-------KCRCSDKPKSGKPGDVS--------IV -NSNRYFRQT-CGSGNN---PTLARD-------KCRCKNK-K--VTNDTD--------QV --GGTYFRKT-ACSSY------YPTG------DKCRCT------------------THDV --GGTYFRKT-ACSSY------YPTG------DKCRCT------------------THDV --GGTYFRKT-ACSSY------YLPG------DKCRCA------------------THDV --GGTYFRQT-CGNND------NWTE------EDCRCAG-----------------NIRV --GSQYFRTT-ACSRN------YQTG------EDCRCR------------------TNDV --GGTYFRKR-ACSSY------YPTG------EDCRCK------------------TNYV --GGTYFRGT-CGKND------TWTR------EDCRCDG-----------------SNVV --GGRYFRQT-CGNND------NWTE------EDCRCAG-----------------NIRV --GGRYFRQT-CGNND------NWTE------EDCRCAG-----------------NIRV --GGRYFRKT-ACSSY------YPTG------DKCRCT------------------THDV --SGTYFRPT-CGDSDGR--SEYQTQ------KQCRCEG-----------------ANVV --NAQYFRGT-CG-SSAK--TATRTP------SQCRCEGAKSA------------NVDQV --DADYFIKT-VC-SGGK--TPTQG--------KCRCIDFS------------------V --DSKYFRQT-CG--NGK--GPSQAK------NKCRCSDKP--------------NTDQV --GGTYFRAT-CGGDNEK--NATLAS------NKCRCDDKTSGAKDG--------DVNIV --GASYFRAT-CDINNEK--GPSVAQ------KQCRCDDKPKGGKAGKGSG----DVNIV QG-FNYFRPT-C--NG----G-KRT------EGYCRCDGD------------------QV EG-DKYFRQT-A--CA----G-TGT------QGKCRCSDN------------------QV S--GTYFRPT-C--NG----G-ERT------EGYCRCNDDKPGHDRP---N------TDP EH-ASYFRAT-CSMNGS---G-AQA------NDKCRCKKNDGTHD-----S------DQV LAGASYFRAT-CD-TGK---GPSQA------HDKCRCKDENGKSE-----T------DQV EG--AYFHAT-CDSGDEK--GQYQT------KNKCTCN----NGD--------------V QG-YKYFLPK-C-SKDTW--SQ----------DKCRCA----NTG--------------V RG-NAYFRAT-C--GDEK--KATLA------DVQCRCTKP--NADQ-------------V TG-NKYFRPT-C--GDSG--SPSMA------RDKCRCGDDKKPNDQ-------------V -G-DKYFRAT-C--GGSE--SPSMA------RDKCRC-D----GDQ-------------V GG-NRYFRQT-C--NGGK--S-STP-------NKCRC-DG--ANTD-------------P DG-DTYFRVT-C--NDNG--TLSHA------NHKCRCPNG---NDQ-------------V DG-DTYFRVT-C--SDGR--GGAQA------NNKCRCPNG---KDQ-------------V QN-AKYFRES-F--SDKG--G---T------YDKCRCASG---N---------------V ES-DKYFRKT-CSGG-K----T-WT------NDKCRCAG----NVR-------------V ND-SQYFRAT-CGSG-RD--AT-RT------RDKCRCAG----NIR-------------V G--SQYFRHT-CGTG-EK--GS-AT------KGKCRCI-----NYD-------------V A--FNYFRHT-CNGG-E------RT------KGYCRCND----DKKPGSNA------DQV -G-NTYFRAT-CGSDEKN--ST-RT------PNQCRCDG----AKG--AKA------DQV QG-AQYFHAT-CGSG-NN--AT-RT------PNKCRCGS----YK--------------V -G-FNYFRHT-CGAG-KD--RT-ET------NHDCQCIN----GD--------------V NN-AQYFRQT-CGGSGKT--GTL-T------KDKCRCGD----GKKTGTNA------DQV G--SHYFGHT-CS-KGQG--G---T------QGNCRCAA----G--------------DV YD-SQYFRAT-CGGDNEN--TTIRT------PSQCRCKDE--NGKKTGTNA------DQV NN-AQYFRQT-CGGSGKT--GTL-T------KDKCRCGD----GKKTGTNA------DQV DYAK-YFRGT-CG-SG---KTGTLT------PNQCRCNDGKKPGKNET---------DQV DYAQ-YFRGT-CG-GDDE-KTGTQA------KNKCRCKD--KNGRPD----------DQV ANYK-YFRVT-CN-DN---GIFSQA------NDKCRCKK--NDGKNET---------DQV GGNR-YFRQT-CG-SG---NNPTLA------RDKCRCKN--KKVTNDT---------DQV SGNN-YFRQT-C--NG-----QHRT------QDNCRCT------THD------------V EADK-YFRNA-CS-ND-----TSDT------NEKCRCDG--RNGTNAGKAG---GNVTIV GGYS-YFRPT-CG-GDN--ESPSVA------NHYCRCND--DNPDDDK--------PNID RDAS-YFHAT-CN-DTG--QGPSQA------TKQCRCGD--G--D-----------VNIV KDAS-YFRPT-CS-DRK--GSCSQA------KDNCRCD----GSNTDQV----------AGAS-YFRAT-CG-GDN--ESPSMA------RDKCRCDDKTSGGKAGEVN--------IV ASAH-YFRAT-C--DTGQ-GP-SVA------NHYCRCDG--RNGTN----------AHQV AGAH-YFRAT-CS-DRDRNGTFSQA------NKYCRCDK--EKGAN----------ADQV ASAS-YFRTT-CS-DT-K-GS-SVA------NNKCRC--------K----------DDQV SNAS-YFRPT-CS-DR-Q-GE-AQA------KNKCRC--------N----------DNQV RDAS-YFRPT-C--GSDEKHS-TLA------SNKCRCDK--DKGAK----------ADQV RDAS-YFRAT-CI-DRNERGQ-SQA------TKQCRCDK--DKGAKD---------GDQV DNSS-YFRAT-CN-DTG--QGPSQT------HNKCRCDK--DKGANAGKPKAGDGDVTIV DNSS-YFRPT-C--DTG--KGPSVA------KDHCRCDG--RNGTNADQ----------V SNAS-YFHAT-CG-DK---KGPSMA------RDKCRCNG--DQ----------------V DNSNRYFRAT-CDSADG--KGSSVA------RNKCRCKD--EEGKNETN---------EV -SGT-YFHAT-CSDSDG--NSKSQA------KDKCRCDD-EPSGGKTGKGS---GDVNIV -HGT-YFHAT-CSDLNG--DC-SQA------HEKCRCP--KTSGGKAIKAG---GDVTIV -YGT-YFRAT-CSDRNG--SF-SQA------KDKCRCE--KKGGGNVN----------IV

0168 0046 0083 0061 0043 0177 1609 0202 0056 0089 0059 0081 0013 0193 0203 0063 0198 0048 1676 0015 0149 0127 0148 0042 0023 0208 0020 0091 0170 0131 0169 1764 0215 0226 0221 0019 0223 0227 0040 0201 0071 0052 0072 0079 0031 0179 0134 0147 0133 0137 0057 0032 0107 0008 0196 0129 0053 0080 0099 0152 0005 0026 0151 0180 0054 1886 1618 1612 0011 0037 0049

-HGT-YFRAT-CSERNG--GC-SQA------NDKCRCP--KTSDGKAND---------QV EGAS-YFRTT-C--SDE--RGGAQA------NDKCRCP--KTSGGKAG-------DVNIV AGAH-YFRQT-CG-SNA--KTGTQA------SHKCRCP--KTSG-TSG-------DVNID DYAQ-YFRGT-C--GNT--KIPSKT------PNKCRCP--KTSGGKPGA------NANQV KNSA-YFRPT-CNG-------GERT------KGYCRCGDGDKPKA--GDGD-----VNIV ANTH-YFRQT-CNG-------GERT------KGYCRCND-DKPKAVKANDN-----VSIV ANAS-YFRPT-CGT-------GTGT------QGRCRCDDGKKPGK--ANDN-----VNVV KNSS-YFRQT-ACA-------GTRT------NDKCRCEG-ANAGK--ANDN-----VNIV AGAS-YFRPT-CSMNGS----GAQA------RNQCRC-DGA----------------NIV KNSS-YFRQT-CSDERG----GAQA------NDKCRCPNGN----------------NQV ASAS-YFRTT-CNDDGT----SSRD------IHKCRCGDGKSNAG-KAGDD-----VNIV AGGT-YFRTT-ACA-GT----SQTD-------GQCRCAT------------------NYV AWGNTYFHAT-CNRGE-R----TKG--------YCRCND--------DQ----------V AGGNKYFRPT-CGSNE-N--TATQAS------HKCRCND--------DQ----------V LASASYFRQT-CGGDE-N--TATQAK------NKCRCND--------DQ----------V --GNAYFRTT-CDSGDNR--GGAQAR------NKCTCNN-------GD-----------V --SNRYFRQT-CGSGE-K--GSATTG-------KCRCSDKPKSGKPGDVSI--------V --ESKYFRLT-C-SG-----GNSSAH------NHCTCVD-------GD-----------P LRGASYFRPT-CNSADGK--GPSQTH------NKCTCNN-------GD-----------V -GS-QYFRKT-CS--DER--GGAQA------NNYCRCGNDQPNADVPNTD---------P -GN-AYFRTT-CNSADGR--GGAQA------NNYCRCNGDKPDDDKANTD---------P -GN-AYFRAT-CS--MNG--SGAQA------NHYCRCNGDQPGQDKTNTD---------P -NNSSYFHAT-CS--MNG--SGAQA------NKYCRCNGDKPDDDKPNID---------P -NNSSYFHAT-CS--DGK--SQSQA------NHYCRCNNDQPNADKPNTD---------P -KNSAYFRVT-CS--DKQ--GESIA------NHKCRCP--MTSDGKPNDQ---------V -GASQYFRAT-CS-DTGQ--GPSMT------PSQCRCD------DKANTD---------P -SNASYFRTT-CN-------GGKRT------EGYCRCNGDKPDNDMVNTD---------P -EDAYYFRQT-C--------GGEKT------ASTNKCR-------CVNTD---------P -SDK-YFRNT-CN-------DSEHSGTFSQPNKYCRCNGDKPGEDKANVD---------P -FN--YFRNT-C-----N--GGEGT------KGYCRCNGDKPDDDKANID---------P -GNA-YFRKT-C-----N--GGEQT------KGYCRCNGDQPGQDRPNTD---------P -SDK-YFRNT-CS----N--DKAGT------SGKCRCNDNQ------------------V -DAS-YFRTT-CSD--RQ--GGAQA------RNKCTCNNGD------------------V -DGS-YFRAT-CGD--SE--SPSQA------RNQCRCQKKDGASV--------------V -GSQ-YFRAT-CN-------GGERT------KGDCQCAAGD------------------V -G-SHYFRPT-CST------E-TWSL----D--KCHCANTD------------------V -DNAQYFRGT-CNY------EGTWSQ----ANHKCRCKKNDG-----KNE------TDQV -G-GKYFRNT-CAS------LTTWTE----TQGNCQCIGQA------------------V -GSYKYSQPT-C--------SEEP-L----SQDKCSCPNAG------------------V -GGGKYFRNT-CGS------AQNPTQ----TEDNCQCIGQA------------------V -DKAQYFRST-C--------SSKG-G----TYKKCRCINGD------------------V -GDGKYFRNT-CGE------GTSP------TQNNCRCINFN------------------V -HGSDYFRHT-CSA------GKYRTA----TNHDCRCINFS------------------V -SGNNYFRHT-CSD------ENHPTA----TQGNCRCIGAT------------------V -DNDKYFRNT-CNG------GEQ-------TKDYCRCDDKSKGGKPGKNE------TDQV -DNAEYFRQT-CGD------STSPSV----AKDHCRCKDEN-GKKTGKNE------SDQV --VDKYFRKT-CGDD-----SGTLSH----ASNKCRCP-------NGKN-------SDQV -QNDKYFRQT-CG-------SGEWT------DNNCRC--------DGKN-------AHQV --GYSYFRPT-CS-D-----GNSKSQ----AKDKCRCEG-----------------ANVV --SYQYSQPT-CS-K------DTLSQ----PK--CSCPN-----------------AG-V --SGTYFRPT-CGGD-----NESPSM----AKNNCRCEG-----------------ANVV ---GTYFRAT-CSDSHR---SETFSQ----AKDNCRC--------DG----------DQV ---GTYFRAT-CGDEEK---KSTL------AKNNCRCKKE-----DGKSE------TDQA -G--TYFRAT-CSDSHRSETFSQAKDN-------CRC-DGDQV-----------------DDDKYFREK-NSNGN---TCTVNK---------CKCVDGD-P-----------------SDDKYFREK-NSEGN---DCFVHK---------CKCANTD-P-----------------ADDKYFRKT-ACAGRS----PTDGR--------CRCAANIDP-----------------QNDKYFRNT--CAGEH----PTNKQ--------CRCVNLGDV-----------------ESDKYFRQT-ACGTGT----PTHKQ--------CRCDDKANVD---------------P -DDDKYFRTT-AC-AGTR---PTDGQ--------CRCKDDQ-V-----------------SDAQYFRNT-CSSI------KGGHY------KNCHCIGGD------------------V -THSDYFRNT-CSND------KASTY------NKCHCIDGT------------------V -NDAKYFRKTVCAGG------TTPTH------EKCTCASGD------------------V -NDAQYFRFT-CLNG------TTRTP------RKCECITHD------------------V -KDAQYFRNA-CSNG------TTVTD------ARCHCIDQT------------------V -DGAFYSARG-CCGG------KGSTG------AYCKCANGD------------------V -DGAFYSARG-CCGG------KGSTG------AYCKCANGD------------------V -DYAKYFRNA-CTND------TTETD------KKCRCATNY------------------V -GGSKYFRHT-CGTG------T-PTD------DKCRCAIND------------------V -VGAQYFGNG-CGDG------KQPTD------TKCRCVSGD------------------P -TGNKYFRRT-CGTGPD----ASPTQ------GKCRCKTNV------------------V

0027 0034 0069 0055 0104 0030 0160 0022 0171 0041 1607 0216 0082 0076 0214 0047 0141 0197 0065 1614 0036 0084 0143 0029 0038 0218 0050 0224 0070 0190 0194 0173 0167 1615

-GGDKYFRNT-CAGG------KTPTQ------GKCRCAAGT------------------V -NEAKYNVIA-SDGT-----TTKSN------YKKCRNIAD-------------------V -KDAKYKVIK-PDGS-----TKDST------WEKCRDVSD-------------------V -DS-HYTKML-ADGS-----IKQSD------MEKCRNITG-------------------V -NSAHYTKSG-ADGS-----ITEST------MGQCRDVAD-------------------V -RDAHYFLKSSPD--------FKSF------SDL-KCGHYE----------------GAP -RDAHYFLKSSPD--------FKSF------SDL-KCGHYE----------------GAP -RDAHYFLKSSPD--------FKSF------SDL-KCGHYE----------------GAP -RDAHYFLKSSPD--------FKSF------SDL-KCGHYE----------------GAP -TGADYFKKKSVD--------TVDF------TNDGKCGHTE----------------GTV -YYADYFKKKSVD--------TVDF------TNDGKCGHNE----------------GAP -RKADYFRNISKR--------IREF------TDIGKCGHNK----------------GSV -YDANYVRRKSDR--------TMDF------TSQGQCGRNEN--------------NGYP -NKSGYFMQ-SKD--------NTLL------SNY-KCGHY----------------EDAP -PKSAYFLQ-SED--------NKQL------FLYPKCGHNN---------------KNDL -DKANYFIYKSGN--------TYNF------TTEGYCGRNE----------------RNV -ENIHYFRKGSDG--------SNLF------SNNGPCGRNE----------------RNV -ENADYFRKGSDG--------SDVF------SNSGKCGRKE----------------APV -DSEDYFIQSEGA--------AKSF------SNS-KCGHG----------------EHEV -GSEEYFIQSENN--------TQLF------SNP-RCGHNK---------------DGDP -EGDRYSKYLAG---------RITT------VSNEKCGHN----------------DDKV -ARDEYFKKPSS---------HEYS------FSNGQCGHR----------------DENV -KDDGYFIKSGY---------RQFK------FTDGHCGRS----------------ETKV -EEDTYS-KIAD---------DGST------LWNDKCDHN----------------EGIV -RDAQYFIKSSV---------RDQT------FSNDYCGHD----------------ENKV -DSEDYFIQSES---------NKKL------FSNSKCGHD----------------ENKV -AADEYFTKSSN---------LEFE------FTGGYCGRN----------------GEKV -KEDHYFKPPKN---------RIRE------FTGGYCGRD----------------ETDV -DNDTYSKYLGVV--------RTT-------LSYPRCGHHV---------------DQDV -VDDISSRNMGNG--------ITS-------FDF-KCGHN----------------DDNV -ENDIFSKNIRNS--------RTTL------FDY-KCAHHV---------------NKDV -HSDEYFRKSTDG--------VTLY------FDG-RCGREL---------------SS-V -EKAKYFKPPKN---------STRE------FTGGKCGRN----------------EEKV -EKAHYFKPSEN---------NTQY------FSNKYCGRD----------------EKKV

0003 0162 0163 0007 0139 0044 0002 0146 0155 0110 1619 0077 0200 0006 0156 0028 0178 0033 0100 0106 0204 0138 0001 1605 0012 0074 1620 0014 1608 0073 0060 0101 0066 0191 1617

L-TNFDYVPQYLRW----L-TNFDYVPQYLRW----L-TNFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFDEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRF----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYLDYVPQYLRWFEEWA P-TYFDYVPQYLRW----P-TYLDYVPQFLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQFLRWFEEWP-TYFDYVPQFLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWF-EWP-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TNFDYVPQFLRWFEEWA P-TSFDYVPQFLRWFEEWP-TYFDYVPQFLRWFDEWP-TYFDYVPQFLRWFDEWP-TYFDYVPQYLRWFDEWP-TYFDYVPQFLRWFEEWP-TYFDYVPQYLRWFEEWA

1621 0058 0130 0229 0075 0132 0181 0187 1606 1622 1611 1887 0051 1613 0126 0004 0010 0067 0109 0153 0078 1616 0017 0068 0021 0102 0098 0228 0064 1610 0039 0085 0016 0174 0024 0168 0046 0083 0061 0043 0177 1609 0202 0056 0089 0059 0081 0013 0193 0203 0063 0198 0048 1676 0015 0149 0127 0148 0042 0023 0208 0020 0091 0170 0131 0169 1764 0215 0226 0221 0019

L-TNFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQFLRWFDEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQFLRWFEEWA P-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWPPTYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQFLRWF-EWP-TYFDYVPQYLRWFEEWA S-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFDEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQFLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLPWFDEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFDEWP-TYFDYVPQYLRW----PPTYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TFFDYVPQYLRW----P-TYFDYVPQYLRWFEEWA P-TYFDYVPQFLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQFLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFDEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TYFDYVPQFLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRWFEEW-

0223 0227 0040 0201 0071 0052 0072 0079 0031 0179 0134 0147 0133 0137 0057 0032 0107 0008 0196 0129 0053 0080 0099 0152 0005 0026 0151 0180 0054 1886 1618 1612 0011 0037 0049 0027 0034 0069 0055 0104 0030 0160 0022 0171 0041 1607 0216 0082 0076 0214 0047 0141 0197 0065 1614 0036 0084 0143 0029 0038 0218 0050 0224 0070 0190 0194 0173 0167 1615

P-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TNFDYVPQYLRWFDEWP-TYFDYVPQYVRWFEEWL-TNFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TNFDYVPQYLRW----P-TYFDYVPQYLRWFDEWP-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TNLDYVPQYLRW----P-TKLDYVPQYLRW----P-TYFDYVPQFVRWFEEWP-TNFDYVPQYLRWFEEWP-TYFDYVPQYLRWFEEWP-TYFDYVPQYLRW----L-TNFDYVPQYLRW----A-TNFDYVPQYLRW----P-TYFDYVPQYLRW----P-TYFDYVPQYLRW----P-TNFDYVPQYLRWFDEWP-TNFDYVPQYLRWFEEWA P-TNFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWA P-TYFDYVPQYLRWFEEWP-TNFDYVPQYLRW----P-TYFDYVPQFLRWFEEWP-TYFDYVPQYLRW----T-TYFDYVPQYLRW----S-TNFDYVPQYLRWFEEWP-TNFDYVPQFLRWFEEWP-TNFDYVPQYLRW----P-TYLDYVPQYLRWF---P-TYLDYVPQYLRW----P-TYLDYVPQYLRW----P-TYLDYVPQYLRW----P-TNLDYVPQFLRWFDEWP-TNLDYVPQFLRWFEEWA P-TYLDYVPQFLRWFDEWL-TNLDYVPQFLRWFDEWP-TNLDYVP-YLRWFDEWP-TNLDYVPQYLRWFDEWP-TYLDYVPQYLRW----P-TYLDYVPQYLRW----P-TYLDYVPQYLRW----L-TNLDYVPQYLRW----L-TNLDYVPQFLRWFEEWA P-TNLDYVPQYLRWFEEWP-TNLDYVPQFLRWFDEWP-TNLDYVPQYLRW----P-TNLDYVPQYLRW----L-TNLDYVPQFLRWFEEWL-TNLDYVPQFLRWFDEWP-TNLDYVPQFLRWFEEWP-TNLDYVPQFLRWFDEWP-TNLDYVPQHLRWFEEWP-TYFDYVPQYLRWFDEWQ-TYLDYVPQYLRWFDEWP-TYLDYVPQFLRWFDEWP-TNLDYVPQYLRWFEEWP-TNLDYVPQFLRWFEEWA * :**** .: :