Sep 1, 2011 - In the morning after polygraphy, fasting venous blood sam- ples were ..... Spittle MA, Hoenich NA, Handelman GJ et al: Oxidative stress and in-.
Biochemical oxidative stress-related markers in patients with obstructive sleep apnea
Authors’ Contribution: A Study Design B Data Collection C Statistical Analysis D Data Interpretation E Manuscript Preparation F Literature Search G Funds Collection
Jana Volná1 ABDEF, David Kemlink1 CD, Marta Kalousová2 AD, Jana Vávrová1 B, Veronika Majerová1 B, Otto Mestek3 B, Jana Švarcová2 B, Karel Šonka1 ADFG, Tomáš Zima2 G
CR
Department of Neurology, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague 3 Institute of Chemical Technology, Prague 1 2
Source of support: This study was supported by Ministry of Education grant VZ0021620816
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Obstructive sleep apnea (OSA) is a condition contributing to oxidative stress. The aim of this study was to ascertain if there is any connection between OSA and novel oxidative stress-related markers. Matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), high sensitive C-reactive protein (hsCRP), pregnancy-associated plasma protein-A (PAPP-A), soluble receptors for advanced glycation end-products (sRAGE), zinc (Zn) and copper (Cu) were measured. Further biochemical markers were evaluated. Fifty-one men suspected for OSA indicated for night polygraphy were included. Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean blood hemoglobin oxygen saturation (SpO2) and time of blood hemoglobin oxygen saturation below 90% (SpO2
