Eur Radiol (2013) 23:1084–1092 DOI 10.1007/s00330-012-2677-x
NEURO
Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936 Benjamin S. Aribisala & Maria C. Valdés Hernández & Natalie A. Royle & Zoe Morris & Susana Muñoz Maniega & Mark E. Bastin & Ian J. Deary & Joanna M. Wardlaw
Received: 14 June 2012 / Revised: 4 September 2012 / Accepted: 15 September 2012 / Published online: 1 November 2012 # European Society of Radiology 2012
Abstract Objective Cerebral atrophy and white matter lesions (WMLs) are common in older people with common risk factors, but it is unclear if they are related. We investigated whether and to what degree they are related in deep and superficial structures using both volumetric and visual ratings. Methods The intracranial, total brain tissue (TBV), cerebrospinal fluid (CSF), ventricular superficial subarachnoid space (SSS), grey matter, normal-appearing white matter, WMLs,
Electronic supplementary material The online version of this article (doi:10.1007/s00330-012-2677-x) contains supplementary material, which is available to authorized users. B. S. Aribisala : M. C. Valdés Hernández : N. A. Royle : Z. Morris : S. Muñoz Maniega : M. E. Bastin : J. M. Wardlaw Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK B. S. Aribisala : M. C. Valdés Hernández : N. A. Royle : S. Muñoz Maniega : M. E. Bastin : I. J. Deary : J. M. Wardlaw Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK B. S. Aribisala : M. C. Valdés Hernández : N. A. Royle : Z. Morris : S. Muñoz Maniega : M. E. Bastin : J. M. Wardlaw Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE), Edinburgh, UK I. J. Deary Department of Psychology, University of Edinburgh, Edinburgh, UK B. S. Aribisala (*) Brain Research Imaging Centre, Division of Clinical Neuroscience, Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK e-mail:
[email protected]
and combined CSF, venous sinuses and dural volumes were measured. WMLs were also rated using the Fazekas scale. Results Amongst 672 adults (mean age 73±1 years), WMLs were associated with global brain atrophy (TBV, β 0 −0.43 mm3, P
