accelerated decline in forced expiratory volume in one second (FEV1). ... dividuals may have enhanced susceptibility to the detrimental effects of cigarette.
Copyright #ERS Journals Ltd 1999 European Respiratory Journal ISSN 0903-1936
Eur Respir J 1999; 14: 1009±1014 Printed in UK ± all rights reserved
Bronchodilator responsiveness and serum total IgE levels in families of probands with severe early-onset COPD J.C. Celedon*,++, F.E. Speizer*,++, J.M. Drazen**,++, S.T. Weiss*,++, E.J. Campbell{, V.J. Carey*, J.J. Reilly**,++, L. Ginns+,++, E.K. Silverman*,**, ++ Bronchodilator responsiveness and serum total IgE levels in families of probands with severe, early-onset COPD. J.C. Celedon, F.E. Speizer, J.M. Drazen, S.T. Weiss, E.J Campbell, V.J. Carey, J. Reilly, L. Ginns, E.K. Silverman. #ERS Journals Ltd 1999. ABSTRACT: Bronchodilator responsiveness has been associated with a subsequent accelerated decline in forced expiratory volume in one second (FEV1). Therefore, bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were assessed in 184 adult first-degree relatives of probands with severe early-onset chronic obstructive pulmonary disease (COPD) and a control group. Greater bronchodilator responsiveness was found among current smokers or exsmokers who were first-degree relatives of early-onset COPD probands than in currently or exsmoking controls, expressed as increase in FEV1 as a percentage of baseline (5.88.1 versus 2.95.1%, p
