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Nov 25, 2016 - Pathology, The Glenfield Hospital, Groby Road, Leicester. In trod action. Haemostatic factors such as fibrinogen and factor VIIc and cholesterol.

Poster and platform presentations Methodology Our protocol offered an oral 100,000iu dose of catdferd to all patients admitted with hip fracture, excluding only those known to be hypercalcaemic, or known to have myeloma or metastatic carcinoma. At initial (1 month) follow-up we assessed the effect by measuring serum PTH and 25 hydroxy-vttamin D (25OHD). Results In follow-up of an untreated control group of 10 patients with hip fracture we have established that serum PTH does not change significantty as a result of the Injury and subsequent surgery. In the first 12 patients to receive 100,000iu of oral calciferol we demonstrated an 8.5 ng/ml (56%) rise In serum 25OHD that was significant at p=0.003 on paired /-test This was accompanied by a 1.4 pmd/1 (30%) fall of serum PTH (significant at p=0.018). In these patients the magnitude of the fail in PTH did not appear to be influenced by admission levels of serum PTH or 25OHD. Conclusion We have Introduced a simple, safe and cheap protocol that has the potential to improve serum PTH, though its effects on bone density and fracture prevention dearly need more detailed study.

Antony Johansen, *Chris BarUett, tRupert Evans, and Mike Stone Bone Research Unit, Academic Department of Geriatric Medidne, 'Collaboration for Accident Prevention and Injury Control (CAPIC), Welsh Combined Centres for Public Health, and Department of Accident and Emergency Medicine. University of Wales College of Medicine, Cardiff

Introduction After fracture some ekierty patients need hospital admission as a direct result of their injury. However, "social" and *non-surgical* problems often coexist, and can precipitate admissions that would not be necessary in younger people with the same injury. Methodology This study was based in eight South Wales A&E departments, between them serving a population of 1.1 million. We Identified all those aged over 55 who presented with fracture and recorded their age, sex, site of fracture, and whether they were admitted. Results During 1096 there were 6,889 fractures in people aged over 55, 2,115 (31%) of which led to admission. The age distribution of hip fracture meant that half of those aged over 85 were admitted; a figure nearly three times that for 55-64 year olds. To avoid this effect we therefore considered different fracture sites separately. For fractures affecting forearm, rib, lower leg and foot, admission was significantly (p