CEBF WI-38 AD WI-38 - PLOS

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WI-38. A ss_10hr ss_15hr. Relative Fold RNA. Levels. 0. 0.2. 0.4. 0.6. 0.8. 1.0. 1.2. 1.4. MALAT1. Cyclin E1. *. *. G1. G1/S. D. 0. 25. 50. 75. 0. 100. 512. 256. 1024.
A Relative Fold RNA Levels

1.4 1.2

B

*

MALAT1 Cyclin E1

G1

G1/S

S

G2

M SRSF1

*

1.0

Tubulin

0.8 0.6 0.4 0.2 0 G1

G1/S

%G1 :56.2 %S :17.2 %G2/M :26.6

75

count

50

50

0

25 0

150 300 450 600

150 300 450 600

PI-A

count

75

0

%G1 :82.5 %S :2.2 %G2/M :15.3

75 50

50 25 0

75

256 512 768 1024

PI-A

25 0 0

256 512 768 1024

0

256 512 768 1024

PI-A

PI-A

PI-A

F

WI-38

MALAT1-AS1

WI-38

50

E

scr-oligo

%G1 :77.2 %S :3.8 %G2/M :19.0

75

0 0

MALAT1-si3

100

%G1 :80.5 %S :1.5 %G2/M:18.0

25

0 256 512 768 1024

MALAT1-si2

100

50

25 0

150 300 450 600

PI-A

MALAT1-si1

100

count

%G1 :42.5 :34.6 %S %G2/M :22.9

0

PI-A

Control-si

100

WI-38

50

0

0

%G1 :55.4 %S :12.9 %G2/M :31.7

75

25

25

D

MALAT1-AS2 100

MALAT1-AS2

8

Relative Fold RNA Levels

count

%G1 :49.5 %S :30.2 %G2/M :20.3

75

MALAT1-AS1

100

count

scr-oligo 100

count

ss_15hr

count

C

ss_10hr

7 6

Control-si MALAT1-si1 MALAT1-si2 MALAT1-si3

*** ***

5 4

**

3

*

2

**

**

*** **

*

1 0

** MALAT1

p21

IL-6

IL-8

Tripathi et al., Fig-S1