Changes in the Immune Response Induced By Sublingual ...

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such as CCR3, CCR4, CCR7, and CCR8 and the PGD2 receptor, CRTH2, are associated with Th2. However, the distribution of these receptors on. Th2 cellsĀ ...
Abstracts AB115

J ALLERGY CLIN IMMUNOL VOLUME 139, NUMBER 2

Atopic Disease in Primary Immune Deficiency with B Cell Dysfunction Amongst a U.S. Immunodeficiency Network (USIDNET) Cohort

Gretchen A. Harmon, MD1,2, Magee L. DeFelice, MD1,2, and Megan Morsheimer, MD, MPH1,2; 1Thomas Jefferson University Hospital, Philadelphia, PA, 2Nemours A.I. duPont Hospital for Children, Wilmington, DE. RATIONALE: Atopic disease is an important consideration in the care of patients with primary immune deficiencies (PID), however, forming the diagnosis may be challenging in patients with low or undetectable serum IgE. We aim to describe the prevalence of allergic disease in a cohort of patients with PID and B cell dysfunction, with the goal of improving recognition of such patients who may benefit from allergy treatment. METHODS: A query was submitted to the USIDNET database to examine associated conditions, allergic reactions, and use of allergen immunotherapy in patients with a diagnosis of a PID with B cell dysfunction. RESULTS: The query identified 2391 cases, the majority (63%) with a diagnosis of common variable immunodeficiency disorders with unknown genetic basis (CVID). Five patients received immunotherapy. For each PID within this cohort, allergic rhinitis and asthma were reported in the following percentages: Activated PI3Kd (0%, 0%), agammaglobulinemia of unknown cause or unlisted gene defect (10%, 20%), AID deficiency (0%, 33%), BTK deficiency (2%, 9%), CD40L deficiency (0%, 4%), CVID (5%, 29%), NEMO deficiency (11%, 26%), Hyper IgM due to uncertain or unlisted cause (