Changes of total antioxidant capacity and total

陨灶贼 允 韵责澡贼澡葬造皂燥造熏 灾燥造援 6熏 晕燥援 4熏 Aug.18, 圆园13 www. IJO. cn 栽藻造押8629原愿圆圆源缘员苑圆 8629-82210956 耘皂葬蚤造押ijopress岳员远猿援糟燥皂

窑Clinical Research窑

Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy

Department of Ophthalmology, Gazi Mustafa Kemal State Hospital, Ankara 06900, Turkey 1

Department of Ophthalmology, Ulucanlar Eye Research and Training Hospital, Ankara 06900, Turkey 2

Department of Ophthalmology, Van Government Hospital,

3

Van, Ankara 06900, Turkey 4 Department of Biochemistry, Numune Research and Training Hospital, Ankara 06900, Turkey Correspondence to: Emrullah Beyazy覦ld覦z. Gazi Mustafa

· CONCLUSION:

Aqueous humor TAC levels are low in

diabetic patients and reduced further in DR patients, TOS levels are increased in diabetic patients and this is exacerbated in DR patients.

· KEYWORDS:

aqueous humor; diabetic retinopathy; total

antioxidant capacity; total oxidant status DOI:10.3980/j.issn.2222-3959.2013.04.23 Beyazy覦ld覦z E, 覶ankaya AB, Ergan E, Anayol MA, 魻zdamar Y, Sezer

Kemal Devlet Hastenesi Silahtar caddesi No.2 Gazi mahallesi Yenimahalle/Ankara 06900, Turkey. dremrullah@

S, T覦rh覦鬤 MH, Y覦lmazba鬤 P, 魶zt俟rk F. Changes of total antioxidant

hotmail.com Received: 2013-03-15

and correlations with diabetic retinopathy.

Accepted: 2013-07-10

·AIM: To measure changes of total oxidant status (TOS) and total antioxidant capacity (TAC) of aqueous humor (DR) patients, and to

determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients.

· METHODS:

One hundred and three eyes of 103

patients who were enrolled for cataract surgery were included in this study. Patients were grouped according to presence of diabetes and stage of DR. Prior to cataract surgery, 0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method.

·RESULTS: TOS levels were highest among proliferative diabetic retinopathy (PDR) patients and lowest in patients with only cataracts. Results were statistically significant between all groups diabetic

without

(