Chemotherapy Reference CGCGTGA 0 0 0 21 0 0 C 5 0 2 0 0 ... - PLOS

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Chemotherapy. Reference. C. G. C. G. T. G. A. 0. 0. 0. 21. 0. 0. C. 5. 0. 2. 0. 0. 0. G. 0 104. 0. 84. 0 108. T. 100. 1 103. 2 108. 0. Control. Reference. C. G. C. G. T.
Supplemental Figure S3 (A) Chromosome 3 DMR CpG Site Sequence CpG Sites



(B) Bisulfite Sequencing Raw Read Counts C to T Conversion

Chemotherapy Reference A C G T Control Reference A C G T

C 0 5 0 100

G 0 0 104 1

C 0 2 0 103

G 21 0 84 2

T 0 0 0 108

G 0 0 108 0

C 1 331 1 271

G 2 0 601 5

C 1 272 2 334

G 124 0 472 18

T 1 0 0 616

G 1 0 616 0

(C) CpG Methylation Percentage Chemotherapy: CpG 1

95% Methylation

CpG 2

98% Methylation

Control: CpG 1

55% Methylation

CpG 2

45% Methylation