Chitotriosidase genotype and plasma activity in patients with type 1 ...

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totrioside, Sigma Chemical Co, St Louis, MO, USA) as described by ..... Medina/Dra. Queipo de Llano. Hos ... Hospital Virgen del Rocío (Sevilla), Dra. Alonso/Dr.
original paper

Hematology & Medicine

haematologica 2001; 86:977-984 http://www.haematologica.it/2001_09/0977.htm

Chitotriosidase genotype and plasma activity in patients with type 1 Gaucher’s disease and their relatives (carriers and non-carriers) PILAR GIRALDO,* ANA CENARRO,° PILAR ALFONSO,° JUAN I. PÉREZ-CALVO,@ DANIEL RUBIO-FÉLIX,* MANUEL GIRALT,* MIGUEL POCOVÍ# *Department of Haematology and °Molecular Research Laboratory, Hospital Universitario Miguel Servet, #Department of Biochemistry, Molecular and Cellular Biology; @Department of Medicine, Hospital Universitario Lozano Blesa; University of Zaragoza, Spain

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of CT activity was observed. However, within 3 years of treatment, a significant difference in the mean decrease of CT activity was present among the group of patients receiving varying alglucerase doses (p