Chorioamnionitis reduces placental endocrine functions - Journal of ...

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samples of approximately 120 g villous tissue were col- lected and thoroughly washed with sterile saline. Chopped tissue fragments were digested with DNase ...
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Chorioamnionitis reduces placental endocrine functions: the role of bacterial lipopolysaccharide and superoxide anion T Okada, N Matsuzaki, K Sawai, T Nobunaga, K Shimoya, K Suzuki1, N Taniguchi1, F Saji and Y Murata Department of Obstetrics and Gynecology and 1Department of Biochemistry, Osaka University Medical School, Suita 565, Osaka, Japan (Requests for offprints should be addressed to N Matsuzaki, 2–2 Yamada-oka, Suita, Osaka, Japan)

Abstract Chorioamnionitis has been shown to be one of the most important factors in inducing preterm delivery. The present study was undertaken to examine the effects of chorioamnionitis on placental endocrine functions. Preterm placentas with histologic chorioamnionitis produced smaller amounts of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) than those without chorioamnionitis (P96%) and the absence of staining for the fibroblast cell marker vimentin (