Mean vBMD of lumbar spine was 122.5 (39.5) mg/cc and femoral neck 233.6 (51.8) mg/cc with no differences between CKD4-5 and CKD5D. There were 53 ...
Nephrology Dialysis Transplantation 30 (Supplement 3): iii205–iii218, 2015 doi:10.1093/ndt/gfv177.16
CHRONIC KIDNEY DISEASE. BONE DISEASE FP417
BONE TURNOVER MARKERS ARE NOT ASSOCIATED WITH BONE DENSITY OR FRAGILITY FRACTURES IN RENAL TRANSPLANT CANDIDATES
Hanne Skou Jørgensen1, Simon Winther2, Morten Bøttcher3, Ellen Hauge4, Lars Rejnmark5, My Svensson1 and Per Ivarsen1 1 Aarhus University Hospital (AUH), Nephrology, Aarhus, Denmark, 2AUH, Cardiology, Aarhus, Denmark, 3Hospitalunit West, Cardiology, Herning, Denmark, 4 AUH, Rheumatology, Aarhus, Denmark, 5AUH, Endocrinology, Aarhus, Denmark Introduction and Aims: Fracture risk is increased in chronic kidney disease (CKD). Disturbed bone remodeling in CKD may affect bone architecture and thereby bone strength. Biochemical markers of bone turnover may be used to assess bone remodeling, but their utility in renal failure is unclear. We investigated the association between bone turnover markers, bone mineral density (BMD) and previous fragility fractures in patients with CKD4-5D. Methods: Adult renal transplant candidates were recruited from four centers. CT scan images were analyzed by dedicated software yielding volumetric BMD (vBMD) of lumbar spine and femoral neck. Previous fragility fractures were defined as fractures resulting from a fall from standing height or less or prevalent vertebral fractures. Blood samples were drawn in the fasting state. Data given as mean (SD) or median [IQR]. Students’ ttest, linear and logistic regression were used, adjusting for age, gender, BMI, diabetes and dialysis status. Results: A total of 146 patients were included. Ninety-seven were men (66.4%) and average age was 54.1 (11.0) years. Eighty patients had CKD4-5 with a mean eGFR of 12.6 ml/min, while 66 received either hemo- or peritonealdialysis. Diabetic nephropathy present in 27.4%. Mean vBMD of lumbar spine was 122.5 (39.5) mg/cc and femoral neck 233.6 (51.8) mg/cc with no differences between CKD4-5 and CKD5D. There were 53 fragility
fractures in 26 patients (11 with VF, 10 with clinical fractures, 5 with both). vBMD was significantly lower in patients with fragility fractures, both at lumbar spine (102.5 (38.6) vs 126.8 (38.5), p
