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Circulation Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargopolicy) will result in the abstract being withdrawn and barred from presentation. LIFESTYLE FACTORS SESSION TITLE: LIPID AND LIPOPROTEIN METABOLISM: RISK FACTORS AND BIOMARKERS
Abstract 15349: Circulating Glycosphingolipids Primarily Correlate With LDLC but Not HDLC or TG and Are Associated With Disease Severity in Acute Myocardial Infarction Sock Hwee Tan, Ghim Siong Ow, Leonardo P de Carvalho, Jianhong Ching, Sock Cheng Poh, Chee Tang Chin, A. Mark Richards, Richard Troughton, Alan Y Fong, Bryan P Yan, Aruni Seneviratna, XiaoXun Yang, Vladimir A Kuznetsov, JeanPaul Kovalik, Scott A Summers, Mark Y Chan
Circulation. 2016;134:A15349
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Abstract Introduction: Circulating cholesterol remains a principal target of therapies aimed at reducing ischemic events after acute myocardial infarction (AMI). Studies have shown that sphingolipids, a class of noncholesterol lipids, may have pro atherogenic properties. Hypothesis: We hypothesized that specific sphingolipid species correlate with cholesterol lipoprotein fractions in AMI and that such associations may identify sphingolipid species with atherogenic and prognostic potential. Methods: Using quantitative tandem mass spectrometry, we measured 91 sphingolipid species, including 18 ceramides (Cer), 16 dihydroCer, 11 sphingomyelins, 12 dihydrosphingomyelins and 34 glycosphingolipids (GSLs) in plasma from 621 AMI patients. Statistical methods, including Kendall’s Tau correlation analysis, were used to investigate the correlation of circulating sphingolipids with lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC) and with triglycerides (TG). Results: The median age of patients was 58 (5266) and 17.8% were women. Sphingolipid species that positively correlated with all 3 lipoproteins included sphingomyelins (C22:1, C20:0), dihydrosphingomyelins (C14:0, C18:2) and Cer C14:0. Unexpectedly, the majority of the GSLs, namely LacCer d18:1/16:0, GlcCer d18:1/22:0 and 24:0, were positively correlated only with LDLC (r > 0.30, FDR
