Accepted Article
Received Date : 07-Jan-2016 Revised Date : 17-Jun-2016 Accepted Date : 18-Jul-2016 Article type : Original Article
Clinical characteristics and factors associated with severe acute respiratory infection and influenza among children in Jingzhou, China Yang Huai1*, Xuhua Guan3,*, Shali Liu 4,*, Timothy M. Uyeki11*, Hui Jiang5,*, John Klena1,2,
Jigui Huang4, Maoyi Chen 6, Youxing Peng7, Hui Yang8, Jun Luo9, Jiandong Zheng5, Zhibin Peng5, Xixiang Huo3, Lin Xiao4, Hui Chen3, Yuzhi Zhang1, Xuesen Xing3, Luzhao Feng5, ,
Dale J. Hu1,2, 10, Hongjie Yu5, Faxian Zhan2,† Jay K. Varma1,2
1
China-US Collaborative Program on Emerging and Re-emerging Infection Disease, Center
for Global Health, Centers for Disease Control and Prevention, Beijing, China 2
Global Disease Detection Branch, Division of Global Health Protection, Center for Global
Health, Centers for Disease Control and Prevention, Atlanta, USA 3
Hubei Provincial Centre for Disease Control and Prevention, Wuhan, China
4
Jingzhou Central Hospital, Jingzhou, China
5
Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on
Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China 6
Jingzhou Center for Disease Control and Prevention, Jingzhou, China
7
Jingzhou First People’s Hospital, Jingzhou, China
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/irv.12419 This article is protected by copyright. All rights reserved.
8
Jingzhou Second People’s Hospital, Jingzhou, China
9
Accepted Article
Jingzhou Maternal and Children's Hospital, Jingzhou, China
10
Vaccine Research Program, Division of AIDS, NIAID/NIH, Bethesda, USA
11
Influenza Division, National Center for Immunization and Respiratory Diseases,
*
Contributed equally to this work
†Corresponding author: Dr. Faxian Zhan, e-mail:
[email protected]
ABSTRACT Background. Influenza is an important cause of respiratory illness in children, but data are limited on hospitalized children with laboratory-confirmed influenza in China. Methods. We conducted active surveillance for severe acute respiratory infection (SARI) (fever and at least one sign or symptom of acute respiratory illness) among hospitalized pediatric patients in Jingzhou, Hubei province from April 2010 to April 2012. Data were collected from enrolled SARI patients on demographics, underlying health conditions, clinical course of illness, and outcomes. Nasal swabs were collected and tested for influenza viruses by RT-PCR. We described the clinical and epidemiological characteristics of children with influenza, and analyzed the association between potential risk factors and SARI patients with influenza. Results. During the study period, 15,354 children aged
