complete CV - CHUV

Virginia HUGHES, M.S. Project Assistant

Complete CV

Virginia Ann HUGHES Service of Endocrinology, Diabetes and Metabolism University Hospital, CHUV Rue du Bugnon 7 BU 7/05/021 CH – 1011 Lausanne, Switzerland Tel : +41 (0)21 692 55 17 Fax : +41 (0)21 692 55 05

General information Professional Experience

2011-present

2003-2011

1998-2003 1985-1997 1982-1984

Chargée de projet Centre Hospitalier Universitaire Vaudois, Service d’Endocrinologie, diabétologie et metabolism, Lausanne, Switzerland Data analyst / Database manager Massachusetts General Hospital, Reproductive Endocrine Unit, Boston, USA USDA Human Nutrition Research Center on Aging Nutrition, exercise physiology and Sarcopenia Laboratory Tufts University, Boston, USA Research Manager Laboratory Supervisor Research assistant

Education 2009 1984 1978

Certificate in Genealogical Research, Boston University M.S. Applied Anatomy and Physiology, Boston University B.A. Chemistry, Emory University

Professional Activities  Reviewer of manuscripts for:  Journal of Applied Physiology  Journal of the American Medical Association  American Journal of Epidemiology

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Virginia HUGHES / Complete CV

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Medicine and Science in Sports and Exercise Diabetes Care Journal of Nutrition for the Elderly European Journal of Clinical Nutrition Clinical Science

 Abstract presentations:   

Federation of the American Society of Experimental Biology American Diabetes Association American College of Sports Medicine

Bibliography Peer-Reviewed Publications

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Gianetti, E, C Tusset, SD Noel, MB Au, AA Dwyer AA, VA Hughes, AP Abreu, J Carroll, E Trarbach, LF Silveira, EM Costa, BB de Mendonca, M de Castro, A Lofrano, JE Hall, E Bolu, M Ozata, R Quinton, JK Amory, SE Stewart, W Arlt, TR Cole, WF Crowley, UB Kaiser, AC Latronico, SB Seminara. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 95(6):2857-2867, 2010. Raivio, T, Y Sidis, L Plummer, H Chen, J Ma, A Mukherjee, E Jacobsen-Dickman, R Quinton, G Van Vliet, H Lavoie, VA Hughes, A Dwyer, FJ Hayes, S Xu, S Sparks, UB Kaiser, M Mohammadi, N Pitteloud. Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 94(11): 4380-90, 2009. Frontera, WR, KF Reid, EM Phillips, LS Krivickas, VA Hughes, R Roubenoff, RA Fielding. Muscle fiber size and function in elderly humans: a longitudinal study. Journal of Applied Physiology 105:637-642, 2008. Hughes, VA, PA Boepple, W Crowley, SB Seminara. The Interplay between the Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness. Neuroendocrinology, Vol. 87(3):142 - 150, 2008.

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Falardeau, J, WC Chung, A Beenken, R Taivio, L Plummer, Y Sidis, E JacobsonDickman, AV Eliseenkova, J MA, A Dwyer, R Quinton, S Na, JE Hall, C Huot, N Alois, SH Pearce, LW Cole, VA Hughes, M Mohammadi, P Tsai, N Pitteloud. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest. 118(8):2822-31, 2008 Ravio, T, J Falardeau, A Dwyer, R Quinton, FJ Hayes, VA Hughes, LW Cole, SH Pearce, H Lee, P Boepple, WF Crowley, N Pitteloud. Reversal of Idiopathic Hypogonadotropic Hypgonadism. New England Journal of Medicine. 357(9):863-873, 2007 Pitteloud, N, R Quinton, S Pearce, T Raivio, J Acierno, A Dwyer, L Plummer, VA Hughes, S Seminara, YZ Cheng, WP Li, G Maccoll, AV Eliseenkova, SK Olsen, OA Ibrahimi, FJ Hayes, P Boepple, JE Hall, P Bouloux, M Mohammadi, W Crowley. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropin hypogonadism,. J of Clin Invest. 117(2):457-463, 2007 Pitteloud, N; A Meysing, R Quinton, JS Acierno, AA Dwyer, L Plummer, E Fliers, P Boepple, F Hayes, S Seminara, VA Hughes, J Ma, P Bouloux, M Mohammadi, WF Crowley. Mutations in fibroblast growth factor receptor I cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Molecular and Cellular Endocrinology. 254-255:60-69, 2006 Pitteloud, N, JS Acierno, A Meysing, AV Eliseenkova, J MA, OA Ibrahimi, DL Metzger, FJ Hayes, AA Dwyer, VA Hughes, M Yialamas, JE Hall, E Grant, M Mohammadi, WF Crowely. Mutations in fibroblost growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proceedings of the National Academy of Sciences. 103 (16) 6281-6286, 2006. Hughes, VA, R Roubenoff, M Wood, WR Frontera, WJ Evans, M A FiataroneSingh. Anthropometric assessment of 10 year changes in body composition in the elderly. Am J Clin Nutr. 80:475-482, 2004. Frontera, WR, VA Hughes, LS Krivickas, SK Kim, M Foldvari, R Roubenoff. Strength training in older women: early and late adaptations of size and function in vivo and in single fibers. Muscle and Nerve 27:601-608, 2003. Hughes, V A, WR Frontera, R Roubenoff, WJ Evans, MA Fiatarone-Singh. Body composition changes in the elderly: role of weight change and physical activity. Am J Clin Nutr. 76 (2):473-481, 2002. Jatoi, A, BD Daly, VA Hughes, GE Dallal, J Kehayias, R Roubenoff. Do patients with nonmetastatic non-small cell lung cancer demonstrate altered resting energy expenditure? Annals of Thoracic Surgery. 72(2):348-351, 2002.

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Frontera, WF, VA Hughes, LS Krivickas, R Roubenoff. Contractile properties of aging skeletal muscle. International Journal of Sport Nutrition and Exercise Metabolism. 11:S14-S18, 2001. P Ziegler, R Sharp, VA Hughes, WJ Evans. Nutritional Status of Teenage Female Competitive Figure Skaters. J of the Am Dietetics Association. 102(3), 374-379, 2001. Krivickas, L S, D Suh, J Wilkins, VA Hughes, R Roubenoff, WR Frontera. Ageand Gender-related differences in maximum shortening velocity of skeletal muscle fibers. American Journal of Physical Medicine and Rehabilitation. 80(6):447-455, 2001. Hughes, VA, WR Frontera, M Wood, WJ Evans, GE Dallal, R Roubenoff, MA Fiatarone Singh. Longitudinal muscle function changes in older adults: Influence of muscle mass, physical activity and health. Journal of Gerontology. 56A(5):B209-B217, 2001. Roubenoff, R, VA Hughes, ME Nelson, CM Morganti, JJ Kehayias, MA Fiatarone Singh, S Roberts. The Effect of Gender and Body Composition Method on the Apparent Decline in Lean-Mass adjusted Resting Metabolic Rate with Age. J Gerontology. 55A(12):M757-M760, 2000 Frontera, W R, D Suh, L Krivickas, V A Hughes, R Goldstein, R Roubenoff. Skeletal muscle fiber quality in older men and women. Am J Physiol. 279: C611C618, 2000. Frontera, W R, VA Hughes, RA Fielding, MA Fiatarone, WJ Evans, R Roubenoff. Aging of skeletal muscle: a 12 yr longitudinal study. J Appl Physiol. 88:13211326, 2000. Jatoi, A, BDT Daly, VA Hughes, G E Dallal, R Roubenoff. Prognostic Effect of increased resting energy expenditure prior to treatment for lung cancer. Lung Cancer. 23(2):153-158, 1999. Kehayias, J J, H Zhuang, VA Hughes, L Dowling. Assessment of Body Fat and Lean in the Elderly by Measuring Body Carbon and Oxygen: Validation Against Hydrodensitometry. Appl Radiat Isot. Vol 49(5/6):723-725, 1998. Fielding, RA, WR Frontera, VA Hughes, EC Fisher, WJ Evans. The Reproducibility of the Bruce Protocol Exercise Test for the Determination of Aerobic Capacity in Older Women. Med Sci Sports Exerc. 29(8):1109-1113, 1997 Liang, P, VA Hughes, NK Fukagawa. Increased Prevalence of Mitochondrial DNA Deletions in Skeletal Muscle of Older Individuals with Impaired Glucose Tolerance: Possible Marker of Glycemic Stress. Diabetes 46:920-923, 1997. Hughes VA, MA Fiatarone, RA Fielding, CM Ferrara, D Elahi, WJ Evans. Long term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. Am J Clin Nutr 62:426-433, 1995.

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Hughes VA, WR Frontera, GE Dallal, KJ Lutz, EC Fisher, WJ Evans. Muscle Strength and body composition: associations with bone density in older subjects. Med Sci Sports Exerc. 27(7):967-974, 1995. Bathalon, GP, VA Hughes, WW Campbell, DA Grimaldo, KJ Lutz, MA Fiatarone, WJ Evans. Body fat estimates from underwater weight and military circumference formulae in middle-aged women. Med Sci Sports Exerc: 27(7): 1079-1085,1995. Hughes, VA, MA Fiatarone, CM Ferrara, JR McNamara, JM Charnley, WJ Evans. Lipoprotein response to exercise training and a low fat diet in older glucose intolerant subjects. Am J Clin Nutr 59:820-826, 1994. Hughes, VA, MA Fiatarone, RA Fielding, BB Kahn, CM Ferrara, P Shepard, EC Fisher, RR Wolfe, D Elahi, WJ Evans. Exercise increases muscle GLUT4 levels and insulin action subjects with impaired glucose tolerance. Am J Physiol, 264:E855-E862, 1993. Frontera, WR, VA Hughes, WJ Evans. Reliability of Isokinetic Muscle Strength Testing in 45 to 78 Year Old Men and Women. Arch Rehab Med: 74:1181-1185, 1993. Frontera, WR, VA Hughes, KJ Lutz, WJ Evans. A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women. J Appl Physiol. 71(2): 644-650, 1991. Meredith, CN, WR Frontera, EC Fisher, VA Hughes, JC Herland, J Edwards WJ Evans. Peripheral effects of endurance training in young and old subjects. J Appl Physiol. 66(6): 2844-2849, 1989. Dawson-Hughes B, H Seligson, VA Hughes. Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in post menopausal women. Am J Clin Nutr. 44:83-88, 1986. Ribeiro JP, VA Hughes, RA Fielding, W Holden, WJ Evans, HG Knuttgen. Metabolic and ventilatory responses to steady state exercise relative to lactate thresholds. Eur J Appl Physiol. 55:215-221, 1986. Fielding, RA, WJ Evans, VA Hughes, LL Moldawer, BR Bistrian. The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid. Eur J Appl Physiol. 55:482-485, 1986. Evans, WJ, CN Meredith, JG Cannon, CA Dinarello, WR Frontera, VA Hughes, BH Jones, HG Knuttgen. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol. 61(5):1864-1868, 1986. Cannon JG, CA Dinarello, WJ Evans, VA Hughes, CN Meredith. Physiological mechanisms contributing to increased interleukin-1 secretion. J Appl Physiol. 61:1869-1874, 1986.

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Ribeiro, JP, RA Fielding, VA Hughes, A Black, MA Bochese, HG Knuttgen. Heart rate breakpoint may coincide with the anaerobic and not the aerobic threshold. Int. J. Sports Med. 6(4):220-4, 1985.

Chapters and Review Articles 4 3 2 1

Roubenoff, R, V A Hughes. Sarcopenia: Current Concepts. J Gerontology. 55A(12):M716-M724, 2000 Hughes, VA, WJ Evans. Effect of Age on Body Fat. J Am Ger Soc 41(11): 1274-1275, 1993. Hughes, VA, and CN Meredith. Effects of aging, exercise and diet on glucose metabolism. Physical Activity, Aging, and Sports. Center for the Study of Aging, Albany, NY. Vol. I (R. Harris and S. Harris, eds.), 1989. Evans, WJ and VA Hughes. Dietary carbohydrates and endurance exercise. Am J Clin Nutr. 41:1146-1154, 1985.

June 2012

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