congenital muscular dystrophy - SciELO

6 downloads 224628 Views 423KB Size Report
Demir E, Sabatelli P, Allamand V, et al. Mutations in ..... Malandrini A, Villanova M, Sabatelli P, et al. Localization ... Sewry CA, D·Alessandro M, Wilson LA, et al.
8ihE\lifgj`hl`Xki)''02-.( 1(++$(-/

M`\njXe[i\m`\nj

:FE>#j`d`cXikfk_XkfYj\im\[`e=:D;ZXj$ \j%8gfjj`Yc\_\Xik`emfcm\d\ek_XjXcjfY\\ei\gfik\[ `egXk`\ekj]ifdZf_fikjf]efejg\Z`ÔZd\ifj`e$gfj`k`m\ :D;.*#.+fijg\Z`ÔZD;:(8.,#.-%K_\i\]fi\#gXk`\ekjn`k_ Xep]fidf]:D;j_flc[Y\ZXi[`fcf^`ZXccp`em\jk`^Xk\[# j`eZ\jlggfik`m\ZXi[`XZk_\iXgpZXegifm`[\fgk`dXc[`j$ \Xj\dXeX^\d\ekXe[ZXi[`XZZfdgc`ZXk`fejdXpdXib$ \[cp`eÕl\eZ\gif^efj`jXe[flkZfd\..#./% DljZc\DI@#`eZfdY`eXk`fen`k_Zc`e`ZXc\mXclXk`fe# ZXeZfeki`Ylk\kf[\k\id`e\k_\Y\jkdljZc\]fiY`fg$ jpXe[`e^\e\iXc_XjY\\e`e[`ZXk\[`e`eÕXddXkfipdp$ fgXk_`\j]fiZfekifcc`e^k_\k_\iXg\lk`Zi\jlck%?fn\m$ \i#`kjmXcl\]fi`e[`ZXk`e^jg\Z`ÔZ[`X^efj\jXe[k_ljj\$ c\Zk`e^k_\Xggifgi`Xk\^\e\k`Zk\jk_Xji\Z\ekcpY\\e i\gfik\[.0#/'#n`k_\dg_Xj`jkfk_\]XZkk_Xk`k`jefe`emX$ j`m\Xe[\Xj`cpXggc`\[`eZ_`c[i\e#\m\en`k_flkj\[Xk`fe/'% FeZ\XgifYXYc\g_\efkpg\_XjY\\ej\c\Zk\[#Xjk_\ dljZc\gXk_fcf^p`jljlXccpefkjg\Z`ÔZf]Xep:D;jlY$ kpg\#k_\`ddlefjkX`e`e^f]dljZc\Y`fgjplj`e^XYXkk\ip f]Xek`Yf[`\j`jXe\jj\ek`Xc`e[`ZXkfi]fik_\dfc\ZlcXi XeXcpj`j=`^) %K_\`ddlef_`jkfZ_\d`ZXci\XZk`fej#gXi$ k`ZlcXicplj\]lc`eZXj\jf]d\ifj`e$[\ÔZ`\ek:D;#ZfccX$ ^\eM@$i\cXk\[[`jfi[\ijXe[:D;jZXlj\[YpXcg_X$[pj$ (+0

:fe^\e`kXcdljZlcXi[pjkifg_p1GXik@ I\\[

kif^cpZXefgXk_p#n`ccY\gi\j\ek\[`ek_\kfg`ZZfii\jgfe$ [\ekkf\XZ_fe\f]k_\j\:D;jlYkpg\j% D;:(81:FE>D;)6d`c[#n`k_efidXc `ek\cc`^\eZ\Xe[`eÕXddXkfip Z_Xe^\jfedljZc\Y`fgjp)'* C>D;)6n`k_d\ekXc i\kXi[Xk`fe(*.

=:D;#=lblpXdXZfe^\e`kXcdljZlcXi[pjkifg_p2C>D;#c`dY^`i[c\dljZlcXi[pjkifg_p2D;:#dljZlcXi[pjkifg_p#Zfe^\e`kXc2DeK(#gifk\`eF$dXefj\Y\kX(#)$E$XZ\kpc^clZfjXd`epckiXej]\iXj\2NNJ#NXcb\i$NXiYli^jpe[ifd\%

=:D;`ek_\AXgXe\j\gfglcXk`feXe[DD;)@g_\efkpg\(*.%:feZ\ie`e^fecpk_\ =BIGdlkXk`fejk_Xkfi`^`eXk\:D;g_\efkpg\j#k_\Ôijk [\jZi`gk`fe*/_X[dX`ecp\dg_Xj`q\[k_\g_\efkpg\D;: (:n`k_flk:EJZ_Xe^\j%?fn\m\i#YiX`e`emfcm\d\ek`jX dfi\Zfddfe]\Xkli\k_Xefi`^`eXccpXek`Z`gXk\[`egX$ k`\ekjn`k_D;:(:(+,#(+-%D\iZli`\kXc%(+,[\jZi`Y\[\`^_k gXk`\ekjn`k_=BIGdlkXk`fejXe[:EJ`emfcm\d\ekk_Xk nXji\gi\j\ek\[Yp1`jfcXk\[Z\i\Y\ccXiZpjkjXe[d\e$ kXci\kXi[Xk`fen`k_flkXepfk_\ij`^ef]gfjk\i`fi]fj$ jXfijlgiXk\ekfi`XcXYefidXc`k`\j`ek_i\\#Xe[Z\i\Y\c$ cXiZpjkjXjjfZ`Xk\[n`k_jkilZkliXcYiX`eZ_Xe^\j`emfcm$ `e^k_\gfjk\i`fi]fjjXXe[k_\Zfik\o`eÔm\%8dfe^k_\

8ihE\lifgj`hl`Xki)''02-.(

cXkk\i#knfgXk`\ekjj_fn\[j\m\i\YiX`eZ_Xe^\jXe[i\$ j\dYc\[Df[]i\p\kXc%(*.glYc`j_\[k_\dfjkZfdgc\k\ XeXcpj`jfek_\^\efkpg\&g_\efkpg\Zfii\cXk`fef]Xcg_X$ [pjkif^cpZXefgXk_`\j#\oZ\gkk_fj\c`eb\[kfdlkXk`fej`e =BIG^\e\#`e`edljZc\Y`fgj`\j _X[j_fn\[_pgf^cpZfjpcXk`fe%K_\gXk`\ekjË;E8nXj jZi\\e\[]fidlkXk`fej`eGFDK(#GFDK)#GFD>eK(#]l$ blk`eXe[C8I>D;g_\efkpg\E4*  XjjfZ`Xk\[kfd\ekXci\kXi[Xk`fe#fe\n`k_DeK( n\i\]fle[`ej\m\egXk`\ekj#j`of]k_\dn`k_NNJXe[ Xj`e^c\ZXj\_X[C>D;g_\efkpg\2dlkXk`fej`e]lblk`e ^\e\n\i\fYj\im\[`ej`ogXk`\ekj#]flif]k_\dn`k_flk :EJ`emfcm\d\ekXe[Xj`e^c\ZXj\f]\XZ_#DeK(^\e\%?fn\m\i#k_\pgf`ek$ \[kfk_\]XZkk_Xkk_\C>D;gXk`\ekn`k_GFD>eK(dl$ kXk`fen_fnXjcXk\ii\gfik\[Yp:c\d\ek\kXc%(,, _XjX d`c[g_\efkpg\Xe[XefidXc`ek\cc`^\eZ\#k_\i\]fi\È[iX$ dXk`ZXccp\ogXe[`e^k_\g_\efkpg\jXjjfZ`Xk\[n`k_dl$ kXk`fej`eGFD>eKÉ%>f[]i\p\kXc%Xcjf(*.\dg_Xj`q\[k_Xk GFDK(Xe[GFDK)dlkXk`fejn\i\ZfddfecpXjjfZ`Xk\[ n`k_:EJ`emfcm\d\ek\m\e`egXk`\ekjn`k_d`c[dljZl$ cXin\Xbe\jj2k_\dXafi`kpf]gXk`\ekjn`k_dlkXk`fej`e ]lblk`e^\e\#fggfj`k\kfk_fj\n`k_kpg`ZXc=:D;#_X[ efkjkilZkliXcYiX`e`emfcm\d\ek2k_\i\]fi\#dlkXk`fej`e k_\]lblk`e^\e\flkj`[\AXgXeXi\XjjfZ`Xk\[kfXd`c[\i (,,

:fe^\e`kXcdljZlcXi[pjkifg_p1GXik@ I\\[

g_\efkpg\%9\j`[\jk_\gi\Z`j\[\jZi`gk`fef]k_\^\ef$ kpg\&g_\efkpg\Zfii\cXk`fe#k_`jnfibXcjf\dg_Xj`q\[ k_XkgXk`\ekjn`k_:D;Xe[Xcg_X$;>_pgf^cpZfj`cXk`fe `en_fdXepdlkXk`fef]k_\befne^cpZfjpckiXej]\iXj\ ^\e\jn\i\]fle[kfj_fnXg_\efkpg`Zjg\Zkildj`d`$ cXikfk_Xkf]gXk`\ekj`en_fddlkXk`fejZflc[Y\`[\ek`$ Ô\[1NNJ`eknf2DD;n`k_ d\ekXci\kXi[Xk`fe`efe\#Xe[C>D;n`k_gli\dljZlcXi `emfcm\d\ek`e(-%8ck_fl^_flkf]k_\X`df]k_\`infib# k_\Xlk_fij(*.Zfej`[\ik_Xkk_\Xdflekf][\gc\k\[^cp$ ZfjpcXk\[\g`kfg\j\\djkfY\Zfii\cXk\[n`k_g_\efkpg$ `Zj\m\i`kp#jfk_XkZfdgc\k\XYj\eZ\`e`ddlefjkX`e`e^ nflc[Y\]fle[`ek_\dfjkj\m\i\ZXj\j%8gXik]ifdk_\ ]XZkk_Xk=BIG`j`e^\e\iXck_\dfjkX]]\Zk\[^\e\#k_\ [`]]\i\eZ\jf]k_\dlkXk`fe]i\hl\eZp`ek_\fk_\i^cpZf$ jpckiXej]\iXj\j^\e\jdXpY\[l\kfi\^`feXc`eÕl\eZ\(*.% @e@kXc`XegXk`\ekjD\jj`eX\kXc%(,+]fle[X^i\Xk\igifgfi$ k`fek_Xe>f[]i\p\kXc%(*.f]GFDK(Xe[GFDK)dlkXk`fej Xe[dlZ_dfi\dlkXk`fej`eGFDK(^\e\k_Xe`eGFDK)% J`d`cXikfk_XkfYj\im\[`ei\cXk`fekfk_\g_\efkpg\# >f[]i\p\kXc%(*.[`[efkÔe[XepmXclXYc\[`]]\i\eZ\`e k_\gXkk\ief][pjkif^cpZXe\ogi\jj`feY\kn\\egXk`\ekj n`k_Xe[n`k_flkdlkXk`fej`eXepf]k_\^\e\j#X]XZk k_Xkjkife^cpjl^^\jk\[k_\gifYXYc\\o`jk\eZ\f]dfi\ ^\e\j`emfcm\[fek_\gXk_nXpf]^cpZfjpcXk`feXe[efk p\k`[\ek`Ô\[lek`ck_\dfd\ek(*.%:Xj\ji\gfikjXe[jkl[$ `\jfejg\Z`ÔZZf_fikjf]gXk`\ekj_Xm\\dg_Xj`q\[k_\ jXd\gifYXY`c`kp(,-$(,/Xe[fk_\i^i\Xk\m`[\eZ\Zfd\j ]ifdk_\dfc\ZlcXijkl[`\j]ifdgXk`\ekjn`k_NNJ%@e jg`k\f]`kjnfic[n`[\[`jki`Ylk`feXe[k_\i\]fi\k_\^ff[ XmX`cXY`c`kpf]gXk`\ekjË;E8]fi^\efd`ZXeXcpj`j#fecp fe\k_`i[kf+'f]k_\ZXj\j_XjY\\eXjjfZ`Xk\[kfdl$ kXk`fej`efe\f]k_\j`o^\e\j`emfcm\[`ek_\F$dXefjp$ cXk`fegXk_nXpj(*.#(,0$(-(% K_\Xdflekf]Xcg_X$;>`ddlefcXY\cc`e^fedljZlcXi Y`fgjp_XjY\\ek_\dfjkgi\Z`j\`e[`ZXkfi]fik_\dfc\Z$ lcXijZi\\e`e^2_fn\m\i#kfZfii\cXk\Zc`e`ZXcZflij\Xe[Xc$ g_X$[pjkif^cpZXecXY\c`e^`jdfi\ZfddfecpfYj\im\[`e gXk`\ekjn`k_dlkXk`fej`eGFDK(#GFDK)Xe[GFD>eK( k_Xe`ek_fj\n`k_[\]\Zkj`e]lblk`eXe[=BIG(-)% K_\dfc\ZlcXiXeXcpj`j`jk_\fecpd\k_f[]fiZfe$ Ôid`e^k_\Xcg_X$[pjkif^cpZXefgXk_pjlYkpg\%:fej`[\i$ `e^k_Xkk_\dfc\ZlcXik\jk`e^`jefkle`m\ijXccpXmX`cXYc\# `k`j`dgfikXekkfi\gfikk_\gfjj`Y`c`kpf]XY`fZ_\d`ZXc XggifXZ_ZfeZ\ie`e^k_\k_i\\^cpZfjpckiXej]\iXj\jk_Xk _Xm\Xci\X[pY\\e`[\ek`Ô\[%@e\okiXZkjf]dljZc\Y`fg$ j`\j]ifdgXk`\ekjGFD>eK(\eqpd\XZk`m`kp_XjY\\e[\$ k\id`e\[lj`e^Zfdd\iZ`XccpXmX`cXYc\i\X^\ekj(-*%CXk\i#X d\k_f[lj`e^eK(#Zfej\hl\ekcp (,-

8ihE\lifgj`hl`Xki)''02-.(

gifm`[`e^k_\i\Zf^e`k`fef]ZXii`\ijXe[k_\[`X^efj`jf] gXk`\ekjn`k_DEK(#GFDK(fiGFDK)`egXk`\ekj n`k_k_\i\jg\Zk`m\dlkXk`fejXe[_XjY\\eZfej`[\i\[X j\ej`k`m\d\k_f[%@kZXegf`ekkffecpfe\dfc\ZlcXik\jk2 `k`jXcjflj\]lc]fii\j\XiZ_\j`ek_\Ô\c[f]gXk_f^\e`Z d\Z_Xe`jdjf]^cpZfjpc$kiXej]\iXj\j(-,% @eZfeZclj`fe#NNJ#D%N\Yi`\Õp gi\j\ekk_\Z_XiXZk\i`jk`ZXjg\Zkjf]\XZ_fe\% ;j`jnVbVXdc\Zc^iVabjhXjaVgYnhigde]n;8B9 =:D;nXjÔijk[\jZi`Y\[`e(0-'Yp=lblpXdX\kXc%() Xe[i\gi\j\ekjfe\f]k_\dfjkZfddfeXlkfjfdXci\$ Z\jj`m\[`jfi[\ij`ek_\AXgXe\j\gfglcXk`fe%8i\Z\eki\$ gfikfe-)AXgXe\j\gXk`\ekjn`k_Xcg_X$[pjkif^cpZXef$ gXk_p#]fle[,+ZXj\jf]=:D;#knff]DZflc[Y\`[\ek`Ô\[(,.%=:D;`jZ_XiXZk\i`q\[Yp :D;XjjfZ`Xk\[kfZfik`ZXcd`^iXk`fe[\]\Zkjd`Zifgf$ cp^pi`X %@e(00*#Kf[X\kXc%)-i\Zf^e`q\[k_\i\jgfej`Yc\ ^\e\fe0h*($**=BKE Xe[cXk\i#`e(00/#BfYXpXj_`\kXc%)0 `[\ek`Ô\[k_\=BKEgif[lZk#]lblk`e#XglkXk`m\^cpZfjpc$ kiXej]\iXj\n`k_+-($Xd`ef$XZ`[j#n_fj\]leZk`feXe[`kj i\cXk`fen`k_fk_\iXcg_X[pjkif^cpZXefgXk_`\j_Xjefk Y\\ep\kZfdgc\k\cp\clZ`[Xk\[(--%8*bY$i\kifkiXejgfjXc `ej\ik`fe`ekfk_\*ËlekiXejcXk\[i\^`fef]k_`j^\e\Zfe$ jk`klk\jk_\]fle[\idlkXk`fek_Xk[\i`m\j]ifdXj`e^c\ XeZ\jkfiXe[fZZlij`edfjk=:D;gXk`\ekj`eX_fdfqp$ ^fljfi_\k\ifqp^fljdXee\i)-#)0#(+*#(-.#(-/%K_`j]fle[\idl$ kXk`fe`jfYj\im\[`ek_\^\e\iXcgfglcXk`fen`k_X]i\$ hl\eZpf]fe\`e//`e[`m`[lXcjXe[`jiXi\flkj`[\k_\AXg$ Xe\j\gfglcXk`fe)0%@eX[[`k`fe#Xkk_\dfd\ekfecpfe\ =:D;gXk`\ekn`k_X]lblk`e_fdfqp^fljdlkXk`fefk_$ \ik_Xek_\]fle[\idlkXk`fe_XjY\\ei\gfik\[1_\_X[ j\m\i\YiX`eXe[\p\XefdXc`\jXe[nXjXKlib`j_Z_`c[ n`k_flkAXgXe\j\XeZ\jkip(-0% =lblpXdX\kXc%[\jZi`Y\[k_\Ôijk(,=:D;ZXj\j`e (0-'()Xe[cXk\i_\Xe[Zfcc\X^l\ji\gfik\[k_\[\kX`cjf] k_`jgXik`ZlcXi]fidf]:D;,*#(.'#(.(%Gffi]\kXcdfm\d\ekj Xe[Y`ik_Xjg_po`XZXeY\k_\Ôijkj`^ej%GXk`\ekjdXe`]\jk ^\e\iXc`q\[dljZc\n\Xbe\jjXe[_pgfkfe`X]ifd\Xicp `e]XeZp#d\ekXci\kXi[Xk`fe#Xe[j\`qli\j%?pg\ikifg_p f]k_\ZXcm\j#hlX[i`Z\gjXe[kfe^l\dljZc\jXi\Zfd$ dfecpj\\e#Xjn\ccXjX[`cXk\[ZXi[`fdpfgXk_pk_XkY\$ Zfd\jjpdgkfdXk`Z`ek_\j\Zfe[[\ZX[\f]c`]\%?fn$ \m\ik_\Zc`e`ZXcdXe`]\jkXk`fejj_fnXmXi`XYc\[\^i\\ f]j\m\i`kp#`eZclj`m\cpXdfe^j`Yc`e^j#Xe[X]\ngXk`\ekj ZXenXcbn`k_flkjlggfik#_Xm\Xc\jj\i[\^i\\f]Zf^e`$

8ihE\lifgj`hl`Xki)''02-.(

k`m\[\ÔZ`\eZpXe[dXpfYkX`ej\`qli\Zfekifc%:\i\YiXc Xe[Z\i\Y\ccXid`Zifgfcp^pi`X#ÔYif^c`Xcgifc`]\iXk`fef] k_\c\gkfd\e`e^\j#_p[ifZ\g_Xclj#]fZXc`ek\i_\d`jg_\i$ `Z]lj`fe#Xe[_pgfgcXj`Xf]k_\Zfik`Zfjg`eXckiXZkjn\i\ k_\YiX`edXc]fidXk`fejfi`^`eXccp[\jZi`Y\[Yp=lblp$ XdX()%FYjkilZk`m\_p[ifZ\g_Xclj`jiXi\%Fee\lif`dX^$ `e^#kiXej`\ekn_`k\dXkk\iXYefidXc`kpk_Xkk\e[jkf[\$ Zi\Xj\n`k_X^\#mXi`XYc\fZZ`g`kXcZfYYc\jkfe\Zfik\o#_p$ gfgcXj`Xf]k_\gfejXe[Z\i\Y\ccXim\id`jXjn\ccXjZ\i$ \Y\ccXiZpjkjZXeXcjfY\i\m\Xc\[(.)%FZlcXiXYefidXc`k`\j dX`ecp[`i\Zk\[kfk_\i\k`eX#jlZ_Xj]fc[`e^#]lj`fe#]fZXc [pjgcXj`X#Xe[[\kXZ_d\ek_Xm\Y\\ei\gfik\[`eX_`^_ eldY\if]gXk`\ekjXZZfdgXe`\[fiefkYpfk_\ifg_k_Xc$ dfcf^`ZXcXck\iXk`fejjlZ_XjXYefidXc\p\dfm\d\ekj# jkiXY`jdlj#dpfg`XXe[d`Zifg_k_Xcdfj(.*% Pfj_`fbXXe[Blifb`(.+ZfdgXi\[jgfiX[`ZXe[]Xd`c`Xc ZXj\j]ifd+(AXgXe\j\]Xd`c`\jXe[]fle[k_Xk`ek_\]X$ d`c`Xc=:D;gXk`\ekj#dfkfi`eZXgXZ`kpnXjdfi\dXib\[% K_\p\dg_Xj`q\[k_XkXkk_\dfjkj\m\i\\e[k_\YifX[ Zc`e`ZXcjg\Zkildf]=:D;ZXe`eZcl[\Xg_\efkpg`Zfm\i$ cXgn`k_d`c[NXcb\i$NXiYli^jpe[ifd\Xe[DD;n`k_Xi\cXk`m\$ cpY\e`^eZflij\#Xe[Xn`[\jg\Zkildf]Zc`e`ZXcj\m\i`$ kp[\g\e[`e^fek_\X^\f]fej\k%GXk`\ekjn`k_Xe\Xicp fej\kn`k_`ek_\Ôijkknfp\Xijf]c`]\gi\j\ek\[X;lZ_$ \ee\$c`b\gif^i\jj`fen`k_dljZc\_pg\ikifg_p`ek_\c\^j Xe[\m\eklXccp`ek_\kfe^l\#Xe[cfjk`e[\g\e[\eknXcb$ `e^[li`e^k_\j\Zfe[[\ZX[\f]c`]\%@efk_\igXk`\ekj n`k_XmXi`XYc\X^\f]fej\kXe[Zflij\jfd\gXk`\ekj n\i\jk`ccXdYlcXek`ek_\Ô]k_[\ZX[\f]c`]\ k_\ZXc]Xe[ kfXc\jj\i\ok\ek#k_`^_#YiXZ_`fiX[`Xc`jXe[kfe^l\dlj$ Zc\jn\i\_pg\ikifg_`Z#Xe[dljZc\ZiXdgj]fccfn`e^\o$ \iZ`j\n\i\Xcjfi\cXk`m\cpZfddfe%8j`kfZZlii\[`eD;$ :(:gXk`\ekj#j\ild:BnXjdXib\[cp`eZi\Xj\[Xe[XmXi`$ XYc\[\^i\\f]_\Xik`emfcm\d\ekZflc[Y\fYj\im\[%K_\ =BIGdlkXk`fej`[\ek`Ô\[`ek_\C>D;)@]Xd`c`\jn\i\ [`]]\i\ek]ifdk_fj\j\\e`eD;:(:(+'% @egXk`\ekjn`k_=BIGdlkXk`fej#9ifne\kXc%(00fY$ j\im\[k_Xkk_\i\j`[lXc\ogi\jj`fef]Xcg_X$;>[\k\Zk$ \[Yp`ddlefcXY\c`e^Xe[N\jk\ieYcfkZXeY\Zfii\cXk\[ n`k_k_\Zc`e`ZXcj\m\i`kpXe[n`k_k_\kpg\f]dlkXk`fe% GXk`\ekjn`k_D;:(:n_f\o_`Y`kXj\m\i\g_\efkpg\Xi\ Zfdgfle[_\k\ifqp^fk\jfe\d`jj\ej\Xe[fe\efej\ej\ dlkXk`fe fi_Xm\_fdfqp^fljd`jj\ej\dlkXk`fej2k_\p

8ihE\lifgj`hl`Xki)''02-.(

j_fnXYj\ekfijkife^cp[\Zi\Xj\[$;>\ogi\jj`fe%?fn$ \m\i#n`k_`ek_\jg\Zkildf]C>D;)@#gXk`\ekjXkk_\j\$ m\i\\e[f]k_\Zc`e`ZXcjg\Zkild;lZ_\ee\$c`b\ k\e[\[ kfj_fnX^i\Xk\ii\[lZk`fe`e`ddlefcXY\c`e^f]Xcg_X$ ;>k_Xek_fj\Xkk_\d`c[\i\e[cXk\ifej\k n_f^\e\iXc$ cpj_fnmXi`XYc\`ddlef_`jkfZ_\d`ZXcgXkk\ieXe[jfd\$ k`d\jgi\j\ekd`e`dXcZ_Xe^\j%GXk`\ekjn`k_k_\dfi\j\$ m\i\;lZ_\ee\$c`b\g_\efkpg\Xi\Zfdgfle[_\k\ifqp$ ^fk\jXd`jj\ej\dlkXk`fe]i\hl\ekcp]fle[Xe[\`k_\i Xefk_\id`jj\ej\fiXefej\ej\dlkXk`fe Xe[gXk`\ekj n`k_k_\d`c[\i]fidf]C>D;)@`e^\e\iXcXi\_fdfqp$ ^flj]fik_\Zfddfe:/)-8&C\l).0@c\=BIGdlkXk`fe(00% 8dc\Zc^iVabjhXjaVgYnhigde]nineZ&9B98&9 Cfe^dXe\kXc%+-XeXcpq\[k_\dfc\ZlcXi[XkX]ifd*- gXk`\ekjn`k_:D;XjjfZ`Xk\[kf\`k_\iZc`e`ZXcfiiX[`f$ cf^`ZXcj`^ejf]:EJ`emfcm\d\ekfin_f_X[XYefidXc Xcg_X$;>`ddlefcXY\c`e^`en_fd`k_X[Y\\e\oZcl[$ \[c`ebX^\kfXepbefne_ldXe:D;cfZlj%8dfe^)0 ]Xd`c`\j`en_`Z_c`ebX^\kfC8I>