Gloucester Royal Hospital, Gloucester, United Kingdom. The reactogenicity and immunogenicity of a serogroup A and C meningococcal polysaccharide-.
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Conjugate Meningococcal Serogroup A and C Vaccine: Reactogenicity and Immunogenicity in United Kingdom Infants Christopher K. Fairley, Norman Begg, Raymond Borrow, Andrew J. Fox, Dennis M. Jones, and Keith Cartwright
Public Health Laboratory Service (PHLS), Communicable Disease Surveillance Centre. London; PHLS Public Health Laboratory. Withington Hospital, Manchester; PHLS Public Health Laboratory. Gloucester Royal Hospital, Gloucester, United Kingdom
Currently, 1300-1500 cases of meningococcal infections are reported each year in England and Wales, although the true burden of disease may be 30%-40% higher due to undemotification [1]. Serogroup C disease accounts for about one-third of these infections, with children 2 p,g/mL 6/54 (II) 52/52 (100) 56/56 (100) 56/56 (100) 25/48 (52)
GMT, U/mL (95% CI)
No. (%) of infants with >200 U/mL
63 (48-82) 1250 (1005-1555) 4101 (3316-5072) 4098 (3397-4944) 230 (183-289)
7/54 (13) 52/52 (100) 56/56 (100) 56/56 (100) 28/48 (58)
Bactericidal GMT* (95% Cl)
