Consumption of cranberry polyphenols enhances ... - Semantic Scholar
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RESEARCH
Open Access
Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study Meri P Nantz1, Cheryl A Rowe1, Catherine Muller1, Rebecca Creasy1, James Colee2, Christina Khoo3 and Susan S Percival1*
Abstract Background: Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms. Methods: The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported. Results: The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p
