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The Influence of 6 Months of Oral Anabolic Steroids on Body Mass and Respiratory Muscles in Undernourished COPD Patients Ivone Martins Ferreira, Ieda T. Verreschi, Luiz E. Nery, Roger S. Goldstein, Noe Zamel, Dina Brooks and Jose R. Jardim Chest 1998;114;19-28 DOI 10.1378/chest.114.1.19 The online version of this article, along with updated information and services can be found online on the World Wide Web at: http://chestjournal.chestpubs.org/content/114/1/19

Chest is the official journal of the American College of Chest Physicians. It has been published monthly since 1935. Copyright1998by the American College of Chest Physicians, 3300 Dundee Road, Northbrook, IL 60062. All rights reserved. No part of this article or PDF may be reproduced or distributed without the prior written permission of the copyright holder. (http://chestjournal.chestpubs.org/site/misc/reprints.xhtml) ISSN:0012-3692

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The Influence of 6 Months of Oral Anabolic Steroids on Body Mass and Respiratory Muscles in Undernourished COPD Patients* Ivone Martins Ferreira, MD, PhD; leda T. Verreschi, MD, Luiz E. Nery, MD, PhD; Roger S. Goldstein, MD, FCCP; Noe Zamel, MD, FCCP; Dina Brooks, BSc (PT), PhD; and Jose R. Jardim, MD, PhD

PhD;

Study objective: To evaluate the influence of oral anabolic steroids on body mass index (BMI), lean body mass, anthropometric measures, respiratory muscle strength, and functional exercise capacity among subjects with COPD. Design: Prospective, randomized, controlled, double-blind study. Setting: Pulmonary rehabilitation program. Participants: Twenty-three undernourished male COPD patients in whom BMI was below 20 kg/m2 and the maximal inspiratory pressure (PImax) was below 60% of the predicted value. Intervention: The study group received 250 mg of testosterone IM at baseline and 12 mg of oral stanozolol a day for 27 weeks, during which time the control group received placebo. Both groups participated in inspiratory muscle exercises during weeks 9 to 27 and cycle ergometer exercises during weeks 18 to 27. Measurements and results: Seventeen of 23 subjects completed the study. Weight increased in nine of 10 subjects who received anabolic steroids (mean, +1.8±0.5 kg; p