Psychopharmacology DOI 10.1007/s00213-014-3516-3
ORIGINAL INVESTIGATION
D2 and D3 dopamine receptor affinity predicts effectiveness of antipsychotic drugs in obsessive-compulsive disorders: a metaregression analysis Deborah Ducasse & Laurent Boyer & Pierre Michel & Anderson Loundou & Alexandra Macgregor & Jean-Arthur Micoulaud-Franchi & Philippe Courtet & Mocrane Abbar & Marion Leboyer & Guillaume Fond
Received: 31 December 2013 / Accepted: 15 February 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Rationale and objective The relationship between clinically effective antipsychotic drugs in obsessive–compulsive disorders (OCD) and binding affinities to cloned dopamine and serotonin receptor subtypes was analyzed in an effort to clarify the contribution of individual receptor subtypes to medication response. Methods Meta-analysis was used to update previous metaanalyses of effectiveness data of add-on antipsychotic drugs to selective serotonin reuptake inhibitors (SSRIs) in OCD. Twelve previously analyzed randomized controlled trials (RCTs) and one new RCT were included. We performed a metaregression using a mixed-effect model to examine the association between antipsychotic’s effectiveness and receptor affinity. Results A total of 5 treatment arms obtained from 13 RCTs (431 patients) were included in our study. The results of our metaregression showed a significant association between D2 D. Ducasse : A. Macgregor : P. Courtet : G. Fond (*) INSERM U1061, Université Montpellier 1, Service Universitaire de Psychiatrie Urgence et Post-urgence, CHU Montpellier, Montpellier 34000, France e-mail:
[email protected] L. Boyer : P. Michel : A. Loundou EA 3279-Self-perceived Health Assessment Research Unit, School of Medicine, La Timone University, 13005 Marseille, France M. Leboyer AP-HP, GHU Mondor, DHU Pepsy, Université Paris-Est, Fondation FondaMental, Fondation de Coopération Scientifique en santé mentale, INSERM U955 Eq 15, Creteil 94000, France J.
