Physiol Biochem 2015;37:1379-1389 Cellular Physiology Cell © 2015 The Author(s). Published by S. Karger AG, Basel DOI: 10.1159/000430403 DOI: 10.1159/000430403 © 2015 The Author(s) online:October October 2015 www.karger.com/cpb Published online: 22,22, 2015 Published by S. Karger AG, Basel and Biochemistry Published 1421-9778/15/0374-1379$39.50/0
1379
Chen et al.: Dachengqi Decoction Inhibits HMGB1 Expression in Severer Acute Accepted: September 02, 2015 www.karger.com/cpb Pancreatitis Mice
This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution IRUFRPPHUFLDOSXUSRVHVDVZHOODVDQ\GLVWULEXWLRQRIPRGLÀHGPDWHULDOUHTXLUHVZULWWHQSHUPLVVLRQ
Original Paper
Dachengqi Decoction Attenuates ,QÁDPPDWRU\5HVSRQVHYLD,QKLELWLQJ +0*%0HGLDWHG1)NJ%DQG30$3. 6LJQDOLQJ3DWKZD\VLQ6HYHUH$FXWH Pancreatitis Zhuoan Chena Yafeng Chenb Liyun Panb Hongchang Lib Jiamin Tub Cheng Liua ;LXTLQ'DLa Xiaofen Zhangb Guifang Sunb Dianxu Fengb Laboratory Center, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Department of general surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China a
b
.H\:RUGV 'DFKHQJTLGHFRFWLRQ6HYHUHDFXWHSDQFUHDWLWLV+0*%7/5V1)NJ%VLJQDOLQJSDWKZD\ 0$3.VLJQDOLQJSDWKZD\ $EVWUDFW Background/Aims: 6HYHUH DFXWH SDQFUHDWLWLV 6$3 LV D VXGGHQ LQÁDPPDWLRQ RI WKH SDQFUHDV7KHWUDGLWLRQDO&KLQHVHPHGLFLQHIRUPXOD'DFKHQJTLGHFRFWLRQ '&4' LVSURYHQ WREHEHQHÀFLDOLQWKHFRPSUHKHQVLYHWUHDWPHQWIRUSDQFUHDWLWLVSDWLHQWVLQFOLQLFDOSUDFWLFH +RZHYHUWKHPROHFXODUPHFKDQLVPRI'&4'RQ6$3UHPDLQVXQFOHDU+LJKPRELOLW\JURXS box 1(HMGB1) that functions as a damage-associated molecular pattern molecule (DAMP) has attracted much interest. Methods: In this study, we used lipopolysaccharide (LPS) and FHUXOHLQWRLQGXFHVHYHUHDFXWHSDQFUHDWLWLVLQ&%/PLFHZLWKVXEVHTXHQWDGPLQLVWUDWLRQ ZLWKORZPHGLXPDQGKLJKGRVH JNJJNJDQGJNJUHVSHFWLYHO\ RI'&4'Results: '&4'WUHDWPHQWLPSURYHGWKHSDWKRORJLFDOVFRUHDQGGHFUHDVHGVHUXPDP\ODVHDQGOLSDVH in a dose-dependent manner. In addition, it suppressed the immune cell-induced secretion of HMGB1 and its translocation from the nucleus to the cytoplasm, thus repressing the H[SUHVVLRQRI,/DQG71)į)XUWKHUSUHWUHDWPHQWZLWK'&4'GHFUHDVHGUHVSRQVHVRI7/5V DQGVXSSUHVVHGWKHDFWLYDWLRQRI1)NJ%DQGS0$3.SDWKZD\Conclusion: Decreasing the VHFUHWLRQRI+0*%FRXOGUHGXFHSURLQÁDPPDWRU\F\WRNLQHVZKLFKPD\KHOSFXWWLQJGRZQ WKH ULVNV RI GHYHORSPHQW IURP ORFDOL]HG SDWKRORJLFDO FKDQJHV WR D V\VWHPLF LQÁDPPDWRU\ response syndrome and even lead to multiple organ failure. © 2015 The Author(s) Published by S. Karger AG, Basel
Dianxu Feng
Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Road, Shanghai, (China) Fax 86-021-52665957, E-Mail
[email protected]
Downloaded by: ReadCube 198.143.37.65 - 10/25/2015 6:22:55 AM
=&KHQJDQG
