Biochemical Education ELSEVIER
Biochemical Education 26 (1998) 144-148
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From G.P. Parslow and E. J. Wood PII: SO307-4412(98)00119-S Website for Devlin’s Textbook of Biochemistry With Clinical Correlations, Fourth Edition Published April 1997 http://www.wiIey.com/products/subject/life/devlin~index.html The website menu allows access to a description of the New Edition, Table of Contents, Sample Chapter, Examination Copy Request, Biochemistry Resources and an Update on CDROM. The new edition presents biochemistry from a mammalian and human perspective and is aimed at students who are in medical, veterinary, pharmacy, nursing, pre-med and biologically oriented programs. Each of the chapters is authored by educators expert in their area of presentation. One of the most significant new features of the Fourth Edition is the full colour illustration program and redesigned layout. Virtually all of these illustrations, over 1000, are available on a CD-ROM that allows each illustration to be printed or organized as a slide show. The CD-ROM is free with adoption. of the The Clinical Correlations show real life examples principles presented in the material. Expanded by over 30%, they now cover an even greater range of diseases and conditions. For any requests contact
[email protected]
university level research and educational tools on the Internet. INFOMINE is notable for its collection of annotated and indexed links, guides to the Internet for most disciplines, textbooks, conference proceedings, and journals. The life sciences INFOMINE provides interactive access to approximately 400 databases. There is a detailed index of topics. For example under AMINO ACIDS you will find listed Amino Acid Properties, Amino Acid Sequence : Calculator, Amino Acids Quick Reference, The Antibody Resource Page, BioMagResBank, Repository for Data from NMR Spectroscopy on Proteins, Peptides, and many more. PII: SO307-4412(98)00122-S The Association
of American Medical Colleges
http://www.aamc.orglabout/cas/ The AAMC Council of Academic Societies (including the US ASBMB) provides this site with information, tools and services for medical school faculty. The choices include Meetings, Medical Education, Research and Health Care. PII: SO307-4412(98)00123-X
PII: SO307-4412(98)00120-4 Centre for Human Genetics The Federation of American Biology (FASEB)
Societies
for
Experimental http://www2.mc.duke.edu/depts/medicine/medgen/
http://www.faseb.org/opa/opa.html The site includes the section Breakthroughs in Bioscience: A series of illustrated essays that explain recent breakthroughs in biomedical research and how they are important to society. At this time the topics are Unravelling the Mystery of Protein Folding, Cardiovascular Disease and the Endothelium, The Polymerase Chain Reaction, Blood Safety in the Age of AIDS, Serendipity, Science, and a New Hantavirus, Controlling Hypertension: A Research Success Story, Biologists Discover AMAZING Things: An on-line poster with animals, puzzles, and scientists discussing their work.
Duke University (USA) provides a web site suitable for answering questions raised by introductory courses in biochemistry/genetics. Specifically covered are: What is a gene? What is a chromosome? How are genetic disorders inherited in a family? Genetics of Complex Disease, How do scientists search for genes? And How Does One Participate in a Genetic Study? PII: SO307-4412(98)00124-l Database of Enzymes and Metabolic Pathways (EMP) http://biobase.com/emphome.html/homepage.html
PII: SO307-4412(98)00121-6 INFOMINE: over 9,500 links to mine the web Http://hb-www.uer.edu Located at the University INFOMINE is a web resource
of California at Riverside featuring access to important
Although not state of the art (dating to 1996) EMP lays claim to being the largest and most comprehensive collection of enzymatic and metabolic data in either electronic or printed form: It contains 16 400 enzymatic records each with more than 300 different fields with properties for each enzyme, covering all aspects of enzymology. More than 10 000 scientific publications have been completely encoded and converted into a fully
Miscellaneous ByteslBiochemical Education 26 (1998) 144-148
queryable database (as opposed to an electronic transcript of literature, which cannot be queried). This part of EMP is commercial (US $400 for one year’s subscription; $2000 for commercial users). EMP is described, with instructions for ordering. The creation of EMP has taken approximately 1.50 man-years to produce the 1412 metabolic pathway diagrams and 500 structures of metabolites which are freely available for downloading. The EMP User Manual includes a complete definition of all concepts of enzymology and metabolism, as used in EMP. The site offers EMP demo versions, with sample datasets and fully functional software (Copyright Ilya A Yunus, 1993-1996). You are welcome to download (for individual and non-commercial use) the collection of 1412 metabolic diagrams, created as part of the EMP database by Professor Evgeni E Selkov (Copyright E E Selkov, 1995, 1996). Evgeni Selkov holds a joint position as Senior Scientist in the Mathematics and Computer Science Division at the US Argonne National Laboratory and as Professor of Biophysics at the Institute of Experimental and Theoretical Biophysics in the Russian Academy of Sciences, Pushchino, Russia. EMP’s metabolic pathway diagrams have become part of the PUMA system, created - and continuously developed - by Ross Overbeek and coworkers at the Argonne National Laboratory, Chicago. PUMA links primary metabolism to phylogeny and to alignments of proteins. PUMA offers a comprehensive functional overview of general metabolism, per-organism overviews, both listed alphabetically and shown superimposed on phylogeny (derived from small subunit rRNA).
project on protein glycosylation for a Principles of Protein Structure Course written by: Christian Frosch at The Institute of Toxicology University of Mainz (US).
PII: SO307-4412(98)00127-7 The Glycoscience Network http://www.vei.co.ukJTGN/ The Glycoscience Network (TGN) is an informal world-wide grouping of scientists who share a common interest in carbohydrates. TGN was set up by Barry Hardy and Iain Wilson who have been responsible for a number of Internet activities related to the Glycosciences. In the autumn of 1994, they collected a large number of e-mail addresses of researchers who were interested in various biological, biochemical, medical, chemical, physical or computational aspects of carbohydrates and glycoconjugates to form the Glycoscience Interest Group (GIG) this led to the founding of the bionet.glycosci newsgroup. Since then Barry and Iain have co-organised a series of Electronic Glycoscience Conferences. They also established The Glycoscience Network Page and proposed the Glycoscience Network Live! concept. In 1997, Christian Frosch and David Ashford were recruited to co-ordinate TGN. The web site has now been completely restructured and updated.
PII: SO307-4412(98)00128-9
PII: SO307-4412(98)00125-3
from Medical Biochemistry Exams Biochemistry, USUHS, Bethesda, MD
Interactive Computer Simulation of an Equilibrium Dialysis to Study the Chemical Properties of Antibody Molecules
http://bob.usuf2.usuhs.miI/biochem/exams/exams.html
http://biowww.chem.utoledo.edu/eqDial/Intro The simulation was created to be an exercise for students in an immunology course at the University of Toledo. by, Charles Creutz,
[email protected]. The experiment is discussed briefly in most current textbooks for medical school courses in immunology. In this simulation you, the experimenter, will establish experimental conditions, obtain data via the simulation and use this data to determine the number of sites on an antibody molecule that bind antigen and the strength of binding between the antibody and the antigenic determinant. Your task is to determine the numerical values for these two important immunochemical properties using the Scatchard Equation. Each day a different antibody with different properties will be used in the simulation. The assumptions are made that only one species of antibody is present in the experiment and that all interaction between antigen and antibody is specific. PII: SO307-4412(98)00126-S
Department
of
The exams available here are arranged according to exam number and year, and by topic covering 1991 to 1996 and possibly 1997. Many of the questions incorporate images that you may click on to obtain the answer. Exams are categorised into sections including Protein Structure and Function, pH and pK, Nucleic Acids, Problem Set: Genetics Case Histories, Carbohydrates and Fats, and Nutrition. A low-tech example for nutrition follows: A child shows poor appetite, lethargy, a dry, scaly dermatitis (even on unexposed skin), growth retardation, a poorly healing wound, and hypogonadism. This patient could best be treated with oral doses of: a. calcium. b. chlorine. c. chromium. d. cobalt. e. copper. f. fluorine. g.iodine. h. iron. i. magnesium. j. manganese. k. molybdenum. 1. phosphorus. m.potassium. n. selenium. o. sodium. p. sulfur. q. vitamin A. r. vitamin D. s. vitamin E. t.vitamin K. u. zinc. Correct answers are provided interactively.
PII: SO307-4412(98)00129-O MCB University
Press Academic Publications
http:/Jwww.mcb.co.uk/
Protein Glycosylation http:/www.uni-mainz.de/
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_ froscOOO/STRU2.html
N-Glycans: their structure and biosynthesis are described and illustrated with GIF images. The site was generated as part of a
Currently, including enjoy the free trials
well over 100 journals are published in various fields science and technology titles The majority of journals benefits of both electronic and printed formats, and are available for all on-line journals. This site also
