Dataset S1

Summary all arrays

Slow vs. Fast growth

Slow growth 2.5% air

Slow growth 0.6% air

Condition A: Td=69h, 50% air Condition A: Td=69h, 2.5% air Condition A: Td=69h, 0.6% air

Locus

GeneN

MSMEG_0001 DNA polymerase III, beta subunit MSMEG_0002 6-phosphogluconate dehydrogenase, decarboxylating MSMEG_0003 DNA replication and repair protein RecF MSMEG_0004 hypothetical protein MSMEG_0005 DNA gyrase, B subunit MSMEG_0006 DNA gyrase, A subunit MSMEG_0007 conserved hypothetical protein MSMEG_0009 hypothetical protein MSMEG_0011 FAD-binding 9, siderophore-interacting MSMEG_0012 ferric enterobactin transport system permease protein FepD MSMEG_0013 ferric enterobactin transport system permease protein FepG; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01032transferase MSMEG_0014 Formyl MSMEG_0015 ferric enterobactin transport ATP-binding protein FepC MSMEG_0016 conserved domain protein MSMEG_0017 ABC transporter, permease/ATP-binding protein MSMEG_0018 ABC transporter, permease/ATP-binding protein MSMEG_0019 amino acid adenylation MSMEG_0020 Periplasmic binding protein MSMEG_0021 aspartate 1-decarboxylase MSMEG_0022 L-ornithine 5-monooxygenase MSMEG_0023 conserved hypothetical protein MSMEG_0024 peptidyl-prolyl cis-trans isomerase B MSMEG_0025 conserved hypothetical protein MSMEG_0026 putative membrane protein

GeneS dnaN

gyrB gyrA

panD

Condition B: Td=4.6h, 50% air Condition B: Td=69h, 50% air Condition B: Td=69h, 50% air Expression Expression Expression ratio Condition p value ratio Condition p value ratio Condition p value A/B A/B A/B 0.89 5.69E-02 0.99 3.63E-01 1.09 3.47E-01 0.83 0.86 0.97 0.78 0.46 0.67 1.47 0.84

6.10E-02 2.19E-02 5.01E-01 1.48E-03 2.13E-05 1.17E-04 6.20E-04 6.47E-02

0.91 0.91 0.95 0.91 1.03 0.86 0.82 1.16

2.34E-01 2.52E-01 5.63E-01 1.03E-01 7.05E-01 6.82E-02 9.65E-02 3.21E-01

1.20 1.76 1.59 0.91 2.75 1.65 1.31 1.08

1.35E-01 1.05E-01 1.52E-02 3.67E-01 1.15E-04 9.43E-02 2.28E-01 7.28E-01

0.54

3.02E-02

1.75

3.00E-01

1.72

1.46E-01

0.60 1.29

5.94E-03 1.65E-01

1.28 0.60

1.47E-01 3.95E-02

1.43 0.88

1.66E-01 2.75E-01

1.40 0.90 0.75 0.84 0.88 0.60 0.77 0.53 1.07 0.50 1.02 0.89

1.86E-01 8.95E-02 8.80E-02 4.30E-02 1.60E-01 3.51E-04 7.30E-03 2.09E-03 4.72E-01 1.62E-04 3.70E-01 4.07E-02

0.69 0.83 1.34 1.21 1.03 0.77 1.00 1.05 0.96 0.76 0.99 1.02

1.15E-02 6.38E-02 8.29E-02 1.61E-01 8.26E-01 7.20E-03 9.87E-01 6.91E-01 6.98E-01 8.13E-02 7.78E-01 4.70E-01

1.11 0.89 1.19 1.10 0.91 0.11 0.39 0.32 1.21 2.34 1.03 1.18

5.31E-01 3.07E-01 4.33E-01 6.70E-01 1.77E-01 1.11E-06 6.85E-03 2.30E-03 1.91E-01 4.86E-02 4.86E-01 9.58E-03

MSMEG_0027 MSMEG_0028 MSMEG_0029 MSMEG_0030 MSMEG_0031 MSMEG_0032 MSMEG_0033 MSMEG_0034 MSMEG_0035 MSMEG_0036 MSMEG_0038

MSMEG_0039 MSMEG_0040 MSMEG_0041 MSMEG_0042 MSMEG_0043 MSMEG_0044 MSMEG_0045 MSMEG_0046 MSMEG_0047 MSMEG_0048 MSMEG_0049 MSMEG_0050 MSMEG_0051 MSMEG_0052 MSMEG_0053 MSMEG_0053 MSMEG_0055 MSMEG_0056 MSMEG_0057 MSMEG_0058 MSMEG_0059

conserved hypothetical protein serine-threonine protein kinase anthranilate synthase component 2 pknA serine/threonine protein kinase PknA Penicillin binding protein transpeptidase domain protein cell cycle protein, FtsW/RodA/SpoVE family protein protein phosphatase 2C FHA domain protein FHA domain protein hypothetical protein putative glucose-methanol-choline oxidoreductase; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error small membrane hydrophobic protein conserved hypothetical protein conserved hypothetical protein TetR-family protein transcriptional regulator extradiol ring-cleavage dioxygenase, class III enzyme, subunit B hypothetical protein hypothetical protein conserved hypothetical protein hypothetical protein pyridoxamine 5'-phosphate oxidase family pirin domain protein conserved hypothetical protein transcription factor WhiB family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved hypothetical protein ATPase, AAA family protein

1.02 0.85 0.96 0.69

8.67E-01 1.29E-01 8.09E-03 2.37E-03

1.11 0.94 0.80 1.30

6.71E-02 3.58E-01 6.65E-02 9.47E-02

0.94 1.24 0.66 1.22

3.92E-01 1.86E-01 9.58E-03 4.04E-02

1.02

5.74E-01

1.15

1.64E-01

1.25

9.69E-03

0.79 0.70 0.79 1.21 1.12

1.78E-02 3.60E-04 5.52E-02 3.51E-02 3.93E-01

1.28 1.00 1.20 1.13 2.39

5.71E-02 9.84E-01 1.25E-01 1.02E-01 8.81E-02

1.25 1.31 1.13 0.56 1.14

2.90E-01 3.13E-01 2.67E-01 9.21E-04 4.67E-01

1.15 1.87 3.65 3.97 0.95

1.58E-01 1.59E-01 1.67E-01 2.61E-01 3.63E-01

0.86 1.76 3.48 4.19 0.91

3.26E-01 1.55E-01 1.75E-01 2.23E-01 1.93E-01

1.35 0.96 1.02 1.07 1.86

4.65E-01 6.23E-01 8.28E-01 3.50E-01 4.29E-01

1.08 0.95 0.82 0.82 0.57 0.57 0.98 1.04 1.81 0.94 0.68 1.09 0.83 1.04 0.85 0.84 0.94

3.63E-01 6.16E-01 2.75E-03 1.51E-02 1.66E-04 4.34E-03 8.79E-01 5.11E-01 8.75E-02 3.12E-01 4.13E-03 3.53E-01 3.68E-02 7.60E-01 3.75E-02 2.40E-03 4.09E-01

3.27 1.06 0.93 0.92 5.42 1.02 8.70 1.16 0.62 0.83 0.82 1.21 1.05 1.17 0.95 0.89 0.87


2.17 2.89 2.01 1.14 0.75 0.74 1.19 0.90 0.81 0.90 0.64 0.82 0.65 0.66 0.75 1.12 0.94


MSMEG_0060 MSMEG_0061 MSMEG_0062 MSMEG_0063 MSMEG_0064 MSMEG_0065 MSMEG_0066 MSMEG_0067 MSMEG_0068 MSMEG_0069 MSMEG_0070 MSMEG_0071 MSMEG_0071 MSMEG_0076 MSMEG_0077 MSMEG_0078 MSMEG_0079 MSMEG_0080 MSMEG_0081 MSMEG_0082 MSMEG_0083 MSMEG_0084 MSMEG_0085 MSMEG_0086 MSMEG_0087 MSMEG_0088 MSMEG_0089 MSMEG_0090 MSMEG_0091 MSMEG_0092 MSMEG_0093 MSMEG_0094 MSMEG_0095 MSMEG_0096 MSMEG_0097 MSMEG_0098

conserved hypothetical protein ftsk/spoiiie family protein ftsk/spoiiie family protein PE family protein ppe family protein conserved hypothetical protein early secretory antigenic target, 6 kDa conserved hypothetical protein probable conserved transmembrane protein translation initiation factor IF-2 protein hypothetical protein conserved hypothetical protein conserved hypothetical protein antigen MTB48 hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein membrane-anchored mycosin mycp1 phosphocarrier protein hpr PTS system, Fru family protein, IIABC components 1-phosphofructokinase glucitol operon repressor phosphoenolpyruvate-protein phosphotransferase ptsI chromosome condensation protein conserved hypothetical protein putative transcriptional regulator probable transcriptional regulatory protein methyltransferase hypothetical protein methyltransferase peroxisomal hydratase-dehydrogenase-epimerase oxidoreductase, zinc-binding dehydrogenase family protein methyltransferase

0.70 0.85 1.32 0.87 0.79 0.68 1.01 1.00 0.74 0.83 1.08 0.76 1.02 0.97 1.22 0.89 0.63 0.52 0.76 0.52 0.73 1.00

5.51E-04 1.54E-02 9.24E-03 1.36E-01 2.47E-02 5.11E-05 9.17E-01 9.78E-01 1.24E-02 8.95E-02 4.09E-01 1.29E-02 5.37E-01 6.25E-01 1.59E-02 1.18E-01 6.53E-03 8.52E-04 9.71E-03 2.82E-04 6.70E-03 9.46E-01

0.99 0.92 0.92 1.42 1.18 1.10 1.22 1.11 0.93 1.13 0.89 0.78 1.03 0.79 0.79 0.82 1.10 1.12 1.20 1.02 1.16 0.86


0.78 0.63 0.49 0.30 0.48 0.27 0.35 0.26 0.79 0.95 1.14 0.74 1.29 0.49 0.45 0.54 0.87 0.87 0.51 1.51 0.58 0.87


1.10 0.96 1.31 1.16 2.26 1.22 1.25 1.67 0.28 1.14 0.35 0.43

4.01E-01 7.45E-01 2.25E-01 3.09E-01 4.71E-02 1.32E-02 3.31E-02 3.58E-02 2.63E-05 4.48E-01 1.17E-04 1.21E-03

1.34 3.73 1.14 1.06 1.80 2.38 1.30 1.00 1.27 6.49 1.08 0.84

1.63E-01 3.22E-01 1.92E-01 4.96E-01 1.23E-01 6.94E-02 4.87E-02 9.83E-01 8.33E-02 1.25E-01 6.50E-01 1.88E-01

0.70 0.87 1.18 0.73 1.05 0.87 1.08 0.26 4.88 0.94 4.28 1.57

1.24E-01 2.85E-01 7.18E-01 1.15E-01 6.23E-01 3.73E-01 4.15E-01 1.95E-04 7.64E-02 7.65E-01 4.35E-02 7.38E-02

0.54 0.62

2.06E-03 1.32E-03

1.05 0.99

6.94E-01 9.24E-01

2.00 1.74

7.78E-02 1.24E-01

MSMEG_0099 MSMEG_0100 MSMEG_0101 MSMEG_0102 MSMEG_0103 MSMEG_0104 MSMEG_0105 MSMEG_0106 MSMEG_0107 MSMEG_0108 MSMEG_0109 MSMEG_0110 MSMEG_0111 MSMEG_0112 MSMEG_0113 MSMEG_0114 MSMEG_0115 MSMEG_0116 MSMEG_0117 MSMEG_0118 MSMEG_0119 MSMEG_0120 MSMEG_0121 MSMEG_0122 MSMEG_0123 MSMEG_0124 MSMEG_0125 MSMEG_0126 MSMEG_0127 MSMEG_0128 MSMEG_0129 MSMEG_0130 MSMEG_0131

conserved hypothetical protein phosphotyrosine protein phosphatase ptpb conserved hypothetical protein putative acyl-CoA dehydrogenase major facilitator family protein transporter transcriptional regulator, LysR family protein DNA-binding response regulator, LuxR family protein sensory histidine kinase cell envelope-related function transcriptional attenuator common domain acyl-CoA dehydrogenase pntB NAD(P) transhydrogenase, beta subunit pntA NAD(P) transhydrogenase, alpha subunit putative magnesium transport protein hypothetical protein taurine transport system permease protein TauC extracellular solute-binding protein, family protein 3 dehII haloacid dehalogenase, type II taurine import ATP-binding protein TauB hydrolase conserved hypothetical protein conserved hypothetical protein probable transcriptional regulatory protein rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrierprotein] reductase putative periplasmic solute-binding protein hypothetical protein transcriptional regulator, GntR family protein integral membrane protein mandelate racemase/muconate lactonizing oxidoreductase, zinc-binding dehydrogenase family protein thioesterase superfamily protein cyclase/dehydrase family protein transcriptional regulator, GntR family protein AMP-binding enzyme, putative

1.05 0.53 1.29 0.63 0.82 0.81

5.24E-01 1.15E-04 4.71E-02 1.60E-03 3.30E-01 6.66E-02

1.21 0.87 0.79 1.02 1.12 1.19

2.53E-01 1.52E-01 8.24E-04 6.88E-01 4.81E-01 1.58E-01

1.00 1.97 1.20 1.21 1.21 1.07

9.39E-01 8.77E-03 2.67E-01 1.04E-01 4.17E-01 2.82E-01

1.35 0.99

1.28E-02 9.42E-01

1.19 1.22

3.59E-02 2.51E-01

0.66 0.94

6.63E-02 2.05E-01

1.29 0.43 0.49 0.51 0.64 1.19 0.65

1.37E-02 1.10E-04 8.86E-06 7.94E-05 1.24E-03 2.86E-01 4.29E-03

1.01 0.85 0.91 0.91 0.91 1.17 8.15

8.79E-01 1.30E-01 1.96E-01 4.29E-01 9.36E-02 5.56E-01 2.41E-01

1.11 0.95 0.83 0.73 0.97 1.34 3.59

3.22E-02 2.02E-01 3.61E-01 3.75E-02 9.20E-01 3.90E-01 2.68E-01

0.45 1.92 0.90 0.96 1.19 1.66 1.13

4.75E-03 4.99E-01 4.31E-02 6.85E-01 4.14E-01 1.05E-03 7.99E-02

9.54 1.21 17.62 1.79 1.08 1.13 1.18

2.24E-01 8.84E-02 3.31E-01 2.12E-01 2.51E-01 2.51E-01 8.15E-02

10.07 1.09 10.61 0.89 1.25 0.85 1.96

1.21E-01 2.28E-01 2.05E-01 2.38E-01 1.34E-01 3.07E-01 1.31E-02

1.16 2.48 0.96 0.97 1.42 0.37

3.14E-02 2.95E-01 7.76E-01 8.33E-01 2.34E-01 1.49E-04

1.01 1.14 1.04 1.09 1.40 1.60

9.35E-01 1.42E-01 7.28E-01 4.50E-01 9.48E-02 3.40E-02

2.43 0.85 0.94 1.35 1.10 1.23

2.87E-02 2.36E-01 4.09E-01 1.38E-01 4.14E-01 3.44E-01

1.20 1.34 0.61 1.02 1.05

1.21E-01 1.46E-01 4.67E-04 4.90E-01 6.20E-01

0.82 0.93 1.04 1.15 0.80

9.35E-02 4.03E-02 5.40E-01 2.72E-01 4.04E-03

1.65 1.31 1.06 0.79 0.15

6.59E-02 3.10E-01 7.51E-01 1.57E-01 5.88E-06


conserved hypothetical protein ABC-transporter integral membrane protein virulence factor Mce family protein virulence factor Mce family protein virulence factor Mce family protein, putative virulence factor mce family protein virulence factor Mce family protein mce-family protein mce1f probable conserved mce associated membrane protein probable conserved mce associated transmembrane protein conserved hypothetical protein probable conserved mce associated membrane protein HNH endonuclease conserved hypothetical protein mosc domain protein C-5 sterol desaturase transcriptional regulator, TetR family protein ThiC family protein NAD(P) transhydrogenase beta subunit PntAB protein Alanine dehydrogenase/pyridine nucleotide transhydrogenase 2-dehydropantoate 2-reductase pyruvate kinase transcriptional regulator transcriptional regulator, LysR family protein oxalyl-CoA decarboxylase formyl-coenzyme A transferase formate dehydrogenase, gamma subunit formate dehydrogenase, beta subunit formate dehydrogenase, alpha subunit NAD-dependent formate dehydrogenase delta subunit conserved hypothetical protein transmembrane transport protein

panE pyk

0.90 1.06 0.79 0.70 0.98 0.83 0.72 0.70

4.18E-01 7.35E-01 6.71E-02 1.78E-03 6.38E-01 8.36E-03 8.98E-04 2.90E-03

0.92 0.79 1.08 1.08 1.07 1.12 0.95 0.92

4.49E-01 1.87E-02 2.61E-02 3.81E-01 8.05E-01 2.10E-01 5.54E-01 3.35E-01

0.21 0.17 0.21 0.23 0.46 0.22 0.22 0.24

3.43E-05 2.09E-05 2.35E-06 4.71E-06 7.00E-03 7.20E-06 3.69E-05 1.80E-04

0.82

4.34E-02

0.82

4.30E-02

0.82

1.06E-01

0.56 0.53

1.60E-04 5.51E-04

0.95 1.28

4.33E-01 7.96E-02

0.78 1.09

8.90E-02 7.36E-01

0.82 1.00 0.69 0.94 1.11 1.71 1.72 1.67 2.08

5.48E-03 9.95E-01 1.48E-01 2.46E-01 2.23E-02 6.09E-02 5.43E-02 1.45E-02 3.43E-02

1.20 1.22 1.04 0.78 0.74 0.79 1.03 0.82 0.81

3.67E-01 1.31E-01 8.23E-01 8.23E-02 9.39E-03 7.11E-02 7.88E-01 5.33E-04 7.16E-02

0.82 1.66 1.28 0.78 0.79 1.08 1.02 0.87 1.03

9.00E-02 3.34E-01 4.46E-01 1.04E-02 2.04E-01 5.12E-01 8.89E-01 1.92E-01 9.54E-01

1.66 1.46 1.51 1.76 1.32 2.04 1.29 0.62 1.46 1.84

3.18E-02 1.19E-02 4.40E-02 5.15E-02 3.64E-02 1.54E-01 3.56E-01 2.14E-03 2.36E-01 7.74E-02

0.90 1.09 0.79 0.87 0.89 0.97 0.80 1.26 1.12 1.22

5.29E-01 5.40E-01 3.83E-02 2.80E-01 2.54E-02 8.35E-01 3.59E-02 2.70E-02 4.05E-01 4.31E-01

0.75 0.93 0.27 0.73 0.94 0.52 0.28 0.99 1.05 1.28

1.08E-01 8.95E-01 2.22E-04 1.68E-01 8.45E-01 2.79E-02 2.74E-03 9.15E-01 7.10E-01 2.04E-01

1.64 1.46 1.19

1.27E-01 2.94E-02 1.41E-01

0.98 1.08 1.16

9.38E-01 4.57E-01 2.89E-01

0.76 0.91 0.90

1.02E-01 1.52E-01 5.44E-01

MSMEG_0165 formate dehydrogenase family protein accessory fdhD protein FdhD MSMEG_0166 GntR-family protein transcriptional regulator MSMEG_0167 transmembrane transport protein MSMEG_0168 formyl-coenzyme A transferase MSMEG_0169 hypothetical protein MSMEG_0170 transmembrane transport protein MSMEG_0171 histone deacetylase superfamily protein MSMEG_0172 probable conserved transmembrane protein, putative MSMEG_0173 hypothetical protein MSMEG_0174 putative inner membrane protein MSMEG_0175 FAD dependent oxidoreductase, putative MSMEG_0176 glutamine ABC transporter periplasmic-binding protein MSMEG_0177 ABC polar amino acid family protein transporter, inner membrane subunit MSMEG_0178 ATP-binding protein MSMEG_0179 transcriptional regulator, GntR family protein MSMEG_0180 putative HTH-type transcriptional regulator MSMEG_0181 alpha-ketoglutarate-dependent taurine MSMEG_0182 epoxide hydrolase 1 MSMEG_0183 conserved hypothetical protein MSMEG_0184 transferase MSMEG_0185 MmpL6 protein MSMEG_0186 MmpS2 protein MSMEG_0187 acetyltransferase MSMEG_0188 MarR-family protein transcriptional regulator MSMEG_0189 conserved hypothetical protein MSMEG_0190 integral membrane transport protein MSMEG_0191 BadF/BadG/BcrA/BcrD ATPase family protein MSMEG_0192 transcriptional regulator, RpiR family protein MSMEG_0193 putative glucokinase regulator MSMEG_0194 serine esterase, cutinase family protein MSMEG_0195 steroid monooxygenase MSMEG_0196 putative dehydrogenase MSMEG_0197 nudix hydrolase MSMEG_0198 acyl-CoA dehydrogenase, C- domain protein

1.07 1.18 8.89 4.99 1.39 5.40 2.29

9.45E-02 4.59E-03 1.62E-02 3.23E-02 2.04E-02 2.29E-04 1.05E-02

1.08 0.94 0.82 0.77 0.57 0.67 0.66

7.43E-01 3.38E-01 2.91E-01 1.06E-01 1.75E-02 2.02E-03 5.90E-03

0.88 0.74 0.07 0.45 1.15 0.20 0.62

2.82E-01 5.64E-03 1.84E-07 2.23E-02 3.52E-01 2.17E-05 1.84E-02

0.33 0.68 0.61 0.96

6.21E-04 4.96E-02 4.43E-03 7.57E-01

0.72 0.98 0.88 1.07

3.61E-02 8.10E-01 6.55E-02 6.54E-01

20.58 1.00 1.37 1.08

3.50E-02 8.99E-01 2.46E-01 5.21E-01

0.84

2.08E-01

0.95

1.69E-01

1.07

5.03E-01

1.08 1.36 1.06 1.32 0.97 1.81 1.04 3.97 1.07 0.75 1.13 0.86 1.72 1.37 0.93 1.74 2.19 0.89 1.89 1.86 1.09 1.22


0.93 1.20 0.90 1.21 0.93 0.99 1.17 0.60 1.25 2.93 0.79 1.05 1.24 1.50 0.97 0.92 0.89 1.03 0.91 0.87 1.06 1.02


1.06 1.01 10.56 0.93 1.22 1.51 1.33 0.93 1.10 0.89 2.26 0.64 1.01 0.97 1.11 0.95 0.94 3.44 0.52 2.59 2.12 1.10


MSMEG_0199 aminoglycoside phosphotransferase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF03881 MSMEG_0200 hypothetical protein MSMEG_0201 hypothetical protein MSMEG_0204 hypothetical protein MSMEG_0205 tetracenomycin polyketide synthesis hydroxylase TcmH MSMEG_0206 acyltransferase 3 MSMEG_0207 MarR-family protein transcriptional regulator MSMEG_0208 ribonuclease MSMEG_0209 ribonuclease inhibitor MSMEG_0210 LprO protein MSMEG_0211 ABC transporter, ATP-binding protein MSMEG_0212 lyase MSMEG_0213 transcriptional regulator MSMEG_0214 L-sorbosone dehydrogenase MSMEG_0215 YhhW family protein MSMEG_0216 3-hydroxyacyl-CoA dehydrogenase MSMEG_0217 alcohol dehydrogenase B MSMEG_0218 3-demethylubiquinone-9 3-methyltransferase MSMEG_0219 RNA polymerase sigma-70 factor, family protein MSMEG_0220 monoglyceride lipase MSMEG_0221 secreted protein MSMEG_0222 conserved hypothetical protein MSMEG_0223 conserved hypothetical protein MSMEG_0224 O-methyltransferase MdmC MSMEG_0225 MmpL4 protein MSMEG_0226 MmpS5 protein MSMEG_0227 transcriptional regulator, TetR family protein MSMEG_0228 adenylate and Guanylate cyclase catalytic domain protein ilvD MSMEG_0229 dihydroxy-acid dehydratase MSMEG_0230 conserved hypothetical protein MSMEG_0231 conserved hypothetical protein MSMEG_0232 sugar transporter family protein MSMEG_0233 lipoprotein Lpps

1.57 6.01 0.99 3.02

4.50E-02 9.37E-04 8.80E-01 2.86E-01

0.75 1.24 1.00 1.62

1.19E-02 2.64E-01 9.89E-01 2.50E-01

1.18 0.78 1.07 0.92

2.50E-01 3.02E-01 1.96E-01 3.96E-01

1.00 2.03 1.01 1.13 0.96 0.65 1.54 1.57 1.56 0.74 0.95 0.75 0.80 2.42 3.44 0.41 0.46 0.65 0.81 1.02 0.62 0.67 1.61

9.87E-01 2.33E-01 9.03E-01 4.75E-01 2.48E-01 4.80E-02 1.87E-03 3.50E-04 5.95E-04 6.56E-02 1.73E-01 6.33E-03 6.61E-02 3.10E-02 9.07E-04 1.94E-03 1.09E-04 1.07E-02 6.17E-01 9.20E-01 8.81E-04 9.14E-04 1.04E-02

1.05 1.17 0.94 1.06 0.97 1.40 0.84 0.82 0.78 0.84 0.95 1.09 0.98 1.20 0.95 0.99 0.94 0.90 1.08 0.84 0.64 0.73 0.58


1.06 2.80 1.00 0.81 1.09 1.24 1.04 0.98 0.81 1.16 1.10 2.08 0.90 0.71 0.34 0.79 0.68 0.86 1.03 1.08 1.09 1.38 0.99


1.39 0.67 1.50 1.45 0.58 1.64

2.21E-01 7.30E-04 3.79E-03 9.05E-03 6.01E-03 4.57E-04

1.13 0.80 0.83 0.86 0.89 0.82

3.98E-01 1.83E-01 1.75E-02 4.83E-02 3.24E-01 1.07E-01

1.16 1.53 0.62 2.38 1.14 0.79

3.07E-01 1.28E-01 1.07E-02 1.08E-01 6.21E-02 9.57E-04


metallopeptidase probable conserved membrane protein putative conserved transmembrane protein O-acetylhomoserine/O-acetylserine sulfhydrylase O-acetylhomoserine/O-acetylserine sulfhydrylase conserved hypothetical protein MmpL11 protein conserved hypothetical protein conserved hypothetical protein two component response transcriptional regulatory protein prra probable conserved transmembrane protein sensor-type histidine kinase PrrB secreted peptidase conserved hypothetical protein integral membrane protein membrane protein, MmpL family protein conserved hypothetical protein trmB tRNA (guanine-N(7)-)-methyltransferase conserved hypothetical protein conserved hypothetical protein phosphoenolpyruvate carboxykinase conserved hypothetical protein acyl-CoA synthase oxidoreductase, short chain dehydrogenase/reductase family protein enoyl-CoA hydratase/isomerase DNA-binding protein p40 protein conserved hypothetical protein amidohydrolase 3 transmembrane transport protein uracil DNA glycosylase superfamily protein arginine decarboxylase esterase transcriptional regulator, GntR family protein 3-oxoacyl-[acyl-carrier-protein] reductase aminoglycoside phosphotransferase

0.99 0.38 0.75 0.47 0.44 2.33 0.87 0.80 1.12

8.37E-01 1.97E-04 4.69E-02 3.56E-04 4.75E-05 1.48E-04 6.97E-02 1.48E-01 2.74E-01

1.06 0.89 0.97 0.99 0.94 0.66 0.86 0.69 0.83

4.28E-01 2.41E-01 6.22E-01 9.51E-01 7.34E-01 2.35E-02 8.03E-03 4.44E-03 2.55E-01

0.70 0.99 1.25 0.72 0.59 0.55 1.55 1.14 0.44

1.30E-02 6.44E-01 1.77E-01 1.57E-01 7.46E-02 3.26E-03 2.82E-02 3.57E-01 7.84E-04

0.71 1.93 0.36 2.16 3.18 1.09 1.10 1.73 1.33 1.27 0.92 1.15 0.94 2.02

1.83E-03 2.41E-04 7.06E-06 1.85E-04 1.48E-04 7.96E-01 3.45E-01 1.11E-02 1.00E-02 4.94E-02 6.98E-02 3.82E-02 6.97E-01 1.33E-02

0.89 0.72 1.09 0.67 0.94 0.78 0.86 0.80 0.96 0.76 0.87 0.69 0.99 0.81

2.43E-01 4.93E-02 3.16E-01 9.79E-03 5.65E-01 1.84E-02 2.41E-01 4.34E-02 5.35E-01 1.59E-02 1.42E-01 5.43E-03 9.77E-01 6.00E-02

0.62 1.24 1.21 1.23 1.55 1.14 0.93 0.91 0.67 1.34 1.45 0.93 1.04 0.33

2.08E-02 4.95E-02 3.31E-01 1.36E-01 1.15E-01 5.62E-01 7.04E-01 5.24E-01 3.82E-02 5.86E-02 1.42E-01 7.18E-01 4.34E-01 3.17E-03

1.64 1.67 1.52 0.56 0.41 0.43 0.47 1.27 1.24 0.98 1.02 0.64 0.75

1.25E-01 1.29E-02 1.00E-03 5.15E-04 8.43E-05 1.99E-06 9.45E-03 2.09E-01 4.13E-01 9.50E-01 5.73E-01 9.93E-05 1.55E-01

1.11 0.95 0.92 1.03 1.28 0.92 0.94 1.11 1.44 1.71 0.99 1.01 0.95

4.03E-01 8.36E-01 3.14E-01 7.13E-01 8.57E-02 3.77E-01 2.48E-01 2.98E-01 2.34E-02 7.50E-02 8.94E-01 9.64E-01 5.17E-01

0.90 0.90 0.93 2.57 2.45 1.65 1.14 1.30 0.81 0.81 1.18 1.01 1.03

4.12E-01 1.93E-01 7.17E-01 4.44E-03 3.80E-02 3.77E-01 2.85E-01 2.23E-01 9.73E-02 6.01E-02 2.85E-01 9.69E-01 9.12E-01


conserved hypothetical protein propanediol utilization protein PduA ethanolamine utilization protein EutN hypothetical protein bacterial microcompartments protein family protein aldehyde-alcohol dehydrogenase putative aminotransferase hypothetical protein amino acid permease alpha/beta hydrolase fold choline dehydrogenase conserved hypothetical protein 3-oxoacyl-[acyl-carrier-protein] reductase ribosyldihydronicotinamide dehydrogenase (quinone) transcriptional regulator TetR family protein GntR-family protein transcriptional regulator conserved hypothetical protein FAD dependent oxidoreductase, putative alpha/beta hydrolase fold family protein acyltransferase, ws/dgat/mgat subfamily protein dioxygenase, TauD/TfdA family protein conserved hypothetical protein Rieske [2Fe-2S] domain protein 3-oxoacyl-(acyl-carrier-protein) reductase oxidoreductase, FAD-binding transcriptional regulator, MarR family protein amidohydrolase conserved hypothetical protein Rieske [2Fe-2S] domain protein amidohydrolase family protein oxidoreductase, FAD-binding peptidase, S9A/B/C families alcohol dehydrogenase, zinc-containing acyl-CoA synthase acyltransferase domain protein arylamine N-acetyltransferase

fabG

1.45 1.42 1.62 0.98

2.32E-01 5.67E-02 5.20E-02 8.08E-01

0.78 1.04 1.01 1.03

2.98E-02 7.94E-01 8.83E-01 8.60E-01

0.93 0.99 1.21 1.14

4.32E-01 7.06E-01 5.26E-01 3.28E-01

2.11 0.99 2.34 0.94 1.82 1.31 2.17 1.49 0.55

2.92E-01 9.07E-01 4.87E-02 6.47E-01 5.70E-02 3.95E-01 3.36E-02 1.24E-01 3.63E-03

1.11 0.94 1.03 1.14 1.73 1.39 0.93 0.72 1.02

1.56E-01 6.30E-01 7.93E-01 2.37E-01 1.68E-01 8.18E-03 6.02E-01 1.02E-01 8.59E-01

1.01 0.81 1.02 0.89 1.00 0.74 0.54 0.43 1.05

5.96E-01 1.56E-01 7.84E-01 2.57E-01 9.15E-01 1.06E-01 5.35E-02 3.40E-04 4.93E-01

1.71 1.47 1.37 1.23 1.21 1.17 0.73 1.10 1.22 1.47 1.90 1.06 2.10 0.92 1.50 1.46 2.28 2.22 0.84 1.87 0.86 1.77 1.76


0.80 0.82 1.17 0.96 1.02 0.83 1.29 0.96 0.98 1.05 0.88 1.01 0.86 1.03 1.14 1.40 0.93 0.74 0.78 1.30 0.83 0.92 1.32


0.81 0.99 1.63 1.28 1.02 1.10 0.95 1.01 1.18 1.04 1.62 1.14 0.92 1.27 1.20 1.31 0.97 1.73 1.44 1.02 1.28 0.91 1.02


MSMEG_0307 MSMEG_0308 MSMEG_0309 MSMEG_0310 MSMEG_0311 MSMEG_0312 MSMEG_0313 MSMEG_0314 MSMEG_0315 MSMEG_0316 MSMEG_0317 MSMEG_0318 MSMEG_0319 MSMEG_0320 MSMEG_0321 MSMEG_0322 MSMEG_0323 MSMEG_0324 MSMEG_0325 MSMEG_0326 MSMEG_0327 MSMEG_0328 MSMEG_0329 MSMEG_0330 MSMEG_0331 MSMEG_0332 MSMEG_0333 MSMEG_0334 MSMEG_0335 MSMEG_0336 MSMEG_0337

transcriptional regulator, AraC family protein dihydrofolate reductase aldehyde dehydrogenase family protein SAM-dependent methyltransferase; this gene contains a frame shift which is not the result of sequencing error glycosyltransferase 2-dehydro-3-deoxyphosphogluconate aldolase/4eda hydroxy-2-oxoglutarate aldolase edd phosphogluconate dehydratase zwf glucose-6-phosphate 1-dehydrogenase probable conserved transmembrane protein putative NagC regulator conserved hypothetical protein AMP-dependent synthetase and ligase acyltransferase putative phosphotriesterase transcriptional regulator glyoxylase family protein; this gene contains a frame shift which is not the result of sequencing error acyl-CoA dehydrogenase, short-chain specific, putative conserved hypothetical protein conserved hypothetical protein AMP-dependent synthetase and ligase aldehyde dehydrogenase hypothetical protein FMN oxidoreductase transcriptional regulator, LuxR family protein transcriptional regulator, LuxR family protein 2-nitropropane dioxygenase, NPD Carboxyl transferase domain protein acetyl-/propionyl-coenzyme A carboxylase alpha chain enoyl-CoA hydratase/isomerase conserved hypothetical protein conserved hypothetical protein

2.47 1.11 2.26

1.54E-01 5.07E-01 2.23E-03

1.24 1.07 0.87

3.16E-01 5.14E-01 1.07E-01

0.86 0.55 0.36

2.77E-01 8.00E-03 5.28E-05

0.89 0.58

6.69E-01 2.02E-03

1.00 1.01

9.60E-01 8.81E-01

1.20 1.52

2.23E-01 5.71E-02

0.68 0.69 0.43 0.50 0.98 0.56 1.61 0.94 1.63 1.29

5.57E-04 4.66E-02 1.50E-03 7.80E-03 7.50E-01 1.39E-04 3.65E-02 7.33E-01 8.98E-03 3.49E-02

1.16 1.08 1.76 0.98 0.79 0.95 1.01 0.85 1.19 0.77

2.39E-01 5.56E-01 1.96E-02 7.98E-01 7.18E-02 4.84E-01 8.51E-01 9.79E-02 3.33E-02 1.94E-02

1.55 4.32 1.28 1.77 1.23 0.82 0.52 0.96 1.29 1.15

1.70E-01 3.26E-01 5.64E-01 1.52E-01 1.55E-01 1.03E-01 4.05E-04 5.96E-01 7.20E-01 4.09E-02

1.26

1.99E-01

0.82

3.01E-01

1.01

3.15E-01

1.58 0.95 1.28 1.10 1.04 2.08 1.53 6.43 5.60 1.12 0.69

3.48E-03 6.87E-01 2.33E-01 2.84E-01 8.22E-01 2.35E-01 1.40E-01 6.68E-02 9.49E-03 5.12E-01 3.23E-02

1.96 1.24 0.94 1.08 1.01 1.22 0.73 1.07 1.15 0.99 0.98

4.05E-01 8.22E-02 5.30E-01 4.93E-01 9.20E-01 4.77E-01 3.05E-03 6.16E-01 4.65E-01 8.75E-01 7.60E-01

0.97 1.60 1.02 1.36 0.91 1.24 1.08 0.07 0.05 0.96 0.80

5.58E-01 4.02E-01 2.67E-01 2.21E-01 2.64E-01 3.40E-01 3.23E-01 5.35E-06 2.09E-07 1.52E-01 7.86E-02

0.76 0.75 1.00 0.66

1.07E-01 1.86E-01 9.83E-01 7.22E-04

0.98 1.00 1.62 1.16

7.91E-01 9.56E-01 1.15E-01 2.50E-01

0.88 0.82 0.80 0.75

1.35E-01 1.34E-01 1.80E-01 3.60E-02


acyl-CoA dehydrogenase fadE12 FMN-dependent monooxygenase enoyl-CoA hydratase/isomerase family protein conserved hypothetical protein hypothetical protein TetR-family protein transcriptional regulator conserved hypothetical protein conserved hypothetical protein virulence factor virulence factor Mce family protein mce-family protein mce3c virulence factor mce family protein virulence factor Mce family protein virulence factor mce family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein acetyltransferase transmembrane transport protein ribonucleoside-diphosphate reductase, beta subunit conserved hypothetical protein conserved hypothetical protein Glycosyl hydrolase family protein 3 amidohydrolase 2 TetR-family protein regulatory protein hypothetical protein conserved hypothetical protein hypothetical protein O-demethylpuromycin-O-methyltransferase hypothetical protein hypothetical protein conserved hypothetical protein MaoC like domain protein oxidoreductase, short chain dehydrogenase/reductase family protein 3-ketoacyl-CoA thiolase

0.73 0.87 1.19 2.27 1.42 0.99 1.12 0.98 0.90 1.97 1.35 1.44 1.44 1.29 1.23 1.50 1.33 1.29 2.02 2.37

1.43E-03 5.51E-03 1.25E-01 9.26E-02 2.87E-01 9.03E-01 3.74E-01 8.55E-01 6.18E-01 1.81E-01 2.28E-01 3.46E-01 2.33E-01 3.08E-01 4.92E-01 2.32E-01 1.19E-01 1.91E-01 2.01E-03 7.88E-02

1.16 0.94 0.94 0.93 0.96 0.86 1.10 1.11 1.29 0.77 0.86 0.94 0.95 0.94 0.86 0.75 0.90 0.75 0.78 0.93


0.94 0.99 1.27 1.18 0.98 1.54 1.26 1.06 1.54 1.01 0.91 1.20 1.01 1.24 1.13 1.11 1.16 0.95 0.90 1.21


4.77 0.58 0.91 0.73 1.12 1.26 1.53 1.22 1.39 0.66 0.66 0.68 0.59 0.67

3.27E-03 7.89E-02 3.52E-02 7.09E-04 3.78E-01 1.99E-02 1.86E-02 9.45E-02 2.66E-01 3.62E-03 5.40E-03 7.41E-03 1.37E-03 1.58E-02

1.03 0.81 1.06 0.80 1.02 0.84 1.07 1.32 0.99 1.07 0.87 1.01 1.00 1.03

8.17E-01 5.31E-02 6.15E-01 5.30E-02 5.98E-01 1.15E-01 2.80E-01 4.70E-02 9.56E-01 4.06E-01 5.60E-01 8.81E-01 9.97E-01 8.00E-01

0.11 1.34 1.23 0.58 1.37 1.12 1.19 1.57 0.45 0.95 1.55 2.00 2.31 1.53

2.24E-06 1.03E-01 2.06E-01 4.29E-02 1.15E-01 6.67E-01 4.88E-01 3.27E-01 1.31E-04 3.73E-01 1.40E-01 6.21E-03 2.74E-02 2.22E-01

0.83 1.29

3.79E-01 9.50E-02

0.90 0.99

3.97E-01 9.39E-01

2.27 1.43

2.22E-01 2.44E-01

MSMEG_0374 MSMEG_0375 MSMEG_0376 MSMEG_0377 MSMEG_0378 MSMEG_0379 MSMEG_0380 MSMEG_0381 MSMEG_0382 MSMEG_0383 MSMEG_0384 MSMEG_0385 MSMEG_0386 MSMEG_0387 MSMEG_0388 MSMEG_0389 MSMEG_0390 MSMEG_0391 MSMEG_0392 MSMEG_0393 MSMEG_0394 MSMEG_0395 MSMEG_0396 MSMEG_0399 MSMEG_0400 MSMEG_0401 MSMEG_0402 MSMEG_0403 MSMEG_0404 MSMEG_0405 MSMEG_0406 MSMEG_0407 MSMEG_0408 MSMEG_0409 MSMEG_0410 MSMEG_0411 MSMEG_0412

glycolate oxidase subunit phospholipase D family protein transcriptional regulator, AraC family protein nitrile hydratase nitrile hydratase, alpha subunit nitrile hydratase activator P14k MmpS4 protein Mmp14a protein putative transport protein conserved hypothetical protein glucose-1-phosphate thymidylyltransferase hypothetical glycosyl transferase NAD dependent epimerase/dehydratase family protein Rmt2 protein Macrocin-O-methyltransferase hypothetical glycosyl transferase putative acyltransferase Rmt3 protein hypothetical glycosyl transferase Fmt protein hypothetical protein hypothetical protein hypothetical protein conserved domain protein peptide synthetase putative non-ribosomal peptide synthase linear gramicidin synthetase subunit D integral membrane protein sigma associated protein extra cytoplasmic sigma factor acyl-coA-dehydrogenase conserved hypothetical protein type I modular polyketide synthase Condensation domain protein MmpL protein acyl-CoA synthase conserved hypothetical protein

nthA

rfbA

tylF

1.11 1.13 0.83 1.61 1.12 1.01 0.61 0.68 0.60 1.82 0.98 1.07

4.51E-01 1.52E-04 2.56E-01 1.08E-01 6.43E-02 8.02E-01 1.57E-03 3.70E-02 6.85E-03 1.13E-02 5.87E-01 4.20E-01

1.13 1.80 1.08 1.27 1.11 0.92 0.97 1.01 1.02 0.77 0.92 1.03

4.98E-01 7.67E-02 4.69E-01 2.34E-01 5.50E-01 4.28E-01 6.86E-01 8.72E-01 7.61E-01 7.08E-02 1.52E-01 3.61E-01

1.02 1.60 1.23 1.01 1.04 1.00 0.48 0.55 0.70 0.74 0.71 0.65

8.32E-01 3.91E-02 3.57E-01 3.81E-01 3.71E-01 9.43E-01 3.54E-03 4.36E-02 7.72E-02 9.65E-02 2.71E-02 3.98E-02

0.57 0.53 0.68 0.41 0.39 0.54 0.82 1.35 0.57 0.94 1.01 1.35 0.75 0.79 0.71 0.53 0.57 0.93 1.55 1.88 0.77 0.38 0.50 0.49 0.95

4.35E-03 8.69E-05 4.87E-04 7.46E-07 2.44E-04 5.54E-03 4.56E-02 2.42E-04 6.84E-04 3.85E-01 9.51E-01 9.39E-03 4.69E-04 1.84E-01 1.18E-03 1.86E-04 5.18E-04 5.99E-01 2.31E-02 6.75E-02 6.45E-02 6.52E-06 8.43E-05 3.08E-05 4.09E-01

0.87 0.87 1.00 0.90 1.09 0.80 0.96 0.88 0.81 1.12 0.71 1.20 1.09 1.02 1.18 0.99 0.91 1.04 2.21 0.99 0.97 1.13 1.03 0.92 0.88


0.68 1.03 0.39 0.67 0.86 1.11 0.88 0.43 1.01 1.17 1.36 1.04 0.70 1.89 1.52 0.93 0.88 2.27 3.70 0.49 1.01 1.53 1.87 1.77 0.84


MSMEG_0413 conserved hypothetical protein MSMEG_0414 oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_0415 NADH-fmn oxidoreductase MSMEG_0416 hypothetical protein MSMEG_0417 succinate dehydrogenase MSMEG_0418 succinate dehydrogenase flavoprotein subunit MSMEG_0419 integral membrane protein MSMEG_0420 conserved hypothetical protein MSMEG_0421 hypothetical protein MSMEG_0422 transferase MSMEG_0423 conserved hypothetical protein MSMEG_0424 Hsp20/alpha crystallin family protein MSMEG_0425 putative membrane protein DcsA MSMEG_0426 transcriptional regulator, GntR family protein nirB MSMEG_0427 nitrite reductase [NAD(P)H], large subunit MSMEG_0428 nitrite reductase [NAD(P)H] small subunit MSMEG_0429 putative ferric uptake regulator MSMEG_0431 secreted protein MSMEG_0432 uroporphyrinogen-III synthetase MSMEG_0433 nitrite extrusion protein MSMEG_0434 aminoglycoside 2'-N-acetyltransferase (AAC(2')Id) MSMEG_0435 allophanate hydrolase subunit 2 MSMEG_0436 allophanate hydrolase subunit 1 MSMEG_0437 conserved hypothetical integral membrane protein MSMEG_0438 Periplasmic binding protein MSMEG_0439 conserved hypothetical protein MSMEG_0440 hypothetical protein MSMEG_0441 conserved hypothetical protein, putative MSMEG_0442 tetracyclin repressor, C- all-alpha domain protein MSMEG_0443 hydrolase, carbon-nitrogen family protein MSMEG_0444 agmatine deiminase MSMEG_0445 amidohydrolase family protein MSMEG_0446 putrescine importer MSMEG_0447 conserved hypothetical protein MSMEG_0448 transcriptional regulator, MarR family protein

1.00

9.65E-01

1.02

5.86E-01

9.97

3.55E-01

1.60 1.55 5.93 3.96 4.37 4.41 9.91 0.91 1.02 1.23 5.15 1.06 1.86 0.94 0.82 0.64 0.33 0.37 1.23

4.70E-03 1.18E-01 1.87E-04 2.78E-02 8.16E-02 5.29E-02 4.10E-02 9.02E-02 7.38E-01 6.50E-02 8.19E-03 2.69E-01 3.87E-01 7.74E-01 6.03E-01 3.05E-03 1.68E-02 7.67E-03 4.10E-01

0.92 0.83 0.88 0.93 0.74 1.07 1.31 1.10 0.88 1.14 1.98 1.22 0.96 1.21 1.39 1.55 0.94 1.14 1.37


1.17 0.78 0.86 0.14 0.09 0.03 0.02 8.79 1.04 0.73 1.53 0.95 1.03 1.28 0.95 1.47 0.90 0.99 1.14


2.57 2.58 2.47 0.56 0.80 0.60 0.80 1.06 1.94 1.13 0.70 0.77 0.81 1.26 1.53

9.60E-04 2.20E-02 1.02E-02 1.37E-03 1.40E-01 3.01E-02 1.34E-02 2.89E-01 3.95E-02 6.13E-01 2.92E-02 1.35E-01 8.33E-02 2.53E-01 3.48E-02

0.65 1.07 1.51 0.85 0.98 2.88 1.34 0.85 0.86 1.09 1.02 0.96 0.83 2.80 0.98


1.61 0.81 0.70 1.00 1.59 1.27 0.76 0.52 1.49 1.32 1.36 0.90 1.10 1.24 0.74


MSMEG_0449 transporter, major facilitator family protein, putative MSMEG_0450 hypothetical protein MSMEG_0451 oxidoreductase, FAD-linked MSMEG_0452 inner membrane permease YgbN MSMEG_0453 shikimate kinase MSMEG_0454 GntR-family protein transcriptional regulator MSMEG_0455 aldehyde dehydrogenase MSMEG_0456 DNA gyrase subunit A MSMEG_0457 DNA topoisomerase IV subunit B MSMEG_0458 two-component system sensor kinase MSMEG_0459 two-component system response regulator MSMEG_0460 alpha/beta hydrolase fold MSMEG_0461 CinZ protein MSMEG_0462 MmpS4 protein MSMEG_0463 MmpL4 protein MSMEG_0464 phosphomethylpyrimidine kinase MSMEG_0465 transcriptional regulator, TetR family protein MSMEG_0466 hypothetical protein MSMEG_0467 membrane transport protein MSMEG_0468 integral membrane protein MSMEG_0469 transcriptional regulatory protein PadRMSMEG_0470 para-nitrobenzyl esterase MSMEG_0471 transcriptional regulator LysR family protein MSMEG_0472 putative lipoprotein MSMEG_0473 transcriptional regulator, LuxR family protein MSMEG_0474 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) MSMEG_0475 nucleotide-sugar dehydrogenase MSMEG_0476 chitin synthase MSMEG_0477 hypothetical protein MSMEG_0478 secreted protein, putative MSMEG_0479 hypothetical protein MSMEG_0480 transcriptional regulator, GntR family protein MSMEG_0481 FAD dependent oxidoreductase MSMEG_0482 dihydroxy-acid dehydratase MSMEG_0483 shikimate transporter MSMEG_0484 formamidase

aroK

0.75 1.24 2.08 2.92 1.74 0.99 1.40 0.35 0.40 1.18 1.14 0.91 1.69 0.64 0.76 1.03 1.94 0.77 5.31 0.55 1.55 7.62 1.06 10.73 0.66


2.11 1.63 2.11 0.85 0.99 0.97 0.93 0.81 0.91 0.96 0.83 0.89 1.12 1.32 1.43 0.96 0.74 1.05 3.80 0.99 1.00 0.66 1.02 0.49 0.91


0.90 1.31 0.21 0.21 1.27 3.23 0.36 1.79 4.43 1.40 0.91 1.09 0.87 1.14 1.04 0.85 1.41 1.42 13.23 1.89 1.14 1.45 1.05 0.64 0.95


1.30 1.44 1.17 0.89 1.26 1.17 0.67 1.35 1.11 1.09 0.90

1.80E-01 2.14E-01 4.98E-01 4.71E-01 1.49E-01 1.75E-01 1.99E-03 3.80E-01 5.00E-01 3.98E-01 5.30E-01

1.08 1.25 1.02 1.26 0.94 1.09 1.01 0.94 0.96 1.06 0.88

2.69E-01 9.30E-02 8.57E-01 1.82E-01 5.65E-01 5.90E-01 9.05E-01 5.77E-01 6.56E-01 6.70E-01 3.79E-01

1.33 0.96 1.11 0.84 1.10 1.63 1.21 0.87 1.01 1.02 0.87

1.61E-01 4.52E-01 2.98E-01 1.35E-01 3.71E-01 3.69E-01 5.40E-01 1.74E-01 6.23E-01 8.06E-01 4.66E-01


amidase putative ABC transporter, periplasmic protein ABC transporter permease ABC transporter ATP-binding protein racemase enoyl-CoA hydratase transcriptional regulator, LacI family protein conserved hypothetical protein hypothetical protein hypothetical protein glycerol dehydratase reactivase chain A, putative; this gene contains a frame shift which is not the result of sequencing error coenzyme B12-dependent glycerol dehydrogenase small subunit glycerol dehydratase large subunit hypothetical protein amino acid permease-associated region regulator of polyketide synthase expression, putative glucosamine-6-phosphate deaminase 1 glucosidase DeoR-family protein transcriptional regulator carbohydrate kinase probable sugar ABC transporter, substratebinding protein, putative ABC transporter, permease protein probable sugar ABC transporter, permease protein glycerol-phosphate porter transcriptional regulatory protein D-tagatose-bisphosphate aldolase, class II, noncatalytic subunit putative sugar isomerase, AgaS family protein BadF/BadG/BcrA/BcrD ATPase family protein integral membrane protein alpha-galactosidase probable sugar transporter sugar binding lipoprotein

1.36 1.18 1.93 1.18 1.14 2.03 1.54 1.02 5.48 2.55

3.07E-01 1.59E-01 2.31E-01 2.70E-01 4.85E-01 1.56E-01 2.14E-01 8.10E-01 2.56E-03 1.36E-02

1.21 0.74 0.99 1.19 1.28 0.95 0.97 0.92 1.91 1.37

4.89E-01 1.05E-01 9.36E-01 1.98E-01 1.34E-01 4.42E-01 9.41E-01 1.07E-01 9.74E-02 1.92E-02

1.08 0.99 0.98 1.05 0.95 1.24 1.68 1.17 1.39 1.07

1.77E-01 6.56E-01 5.76E-01 7.01E-01 4.06E-01 1.25E-01 2.08E-01 3.84E-01 4.03E-01 5.75E-01

1.30

8.25E-02

1.11

1.11E-01

1.25

2.34E-01

1.04 1.07 1.19 1.30

8.47E-01 5.89E-01 1.32E-01 3.44E-01

1.16 0.95 1.17 0.97

3.11E-01 1.02E-01 2.87E-01 7.51E-01

1.08 0.97 1.54 1.10

7.56E-01 6.57E-01 3.64E-01 1.96E-01

0.71 0.55 1.13 0.98 1.24

7.19E-02 7.78E-03 5.70E-01 8.57E-01 3.37E-01

0.99 0.90 0.72 0.90 1.07

8.02E-01 1.62E-01 1.02E-01 2.29E-01 5.93E-01

2.67 0.97 0.87 0.99 0.83

1.10E-01 6.95E-01 3.73E-01 8.34E-01 1.23E-01

1.10 1.01 0.99 1.85 0.95

5.50E-01 9.66E-01 8.66E-01 1.81E-01 6.50E-01

0.76 1.01 0.76 0.97 1.13

1.87E-02 9.63E-01 5.19E-02 8.17E-01 3.54E-01

0.49 0.96 0.98 0.81 0.78

9.37E-03 2.89E-02 5.83E-01 1.26E-01 7.70E-02

2.56 1.47 1.47 1.54 1.13

1.42E-01 2.01E-01 1.59E-01 5.00E-02 3.46E-01

1.17 1.20 1.04 0.98 1.10

2.75E-01 6.19E-02 6.05E-01 8.51E-01 4.58E-01

1.24 1.02 1.02 0.95 2.06

2.59E-01 3.47E-01 4.50E-01 4.11E-01 3.35E-01

1.27

3.97E-01

0.99

8.90E-01

0.91

3.67E-01

MSMEG_0516 sugar transport system MSMEG_0517 sugar binding-protein dependent transporter system permease MSMEG_0518 ABC transporter, nucleotide binding/ATPase protein, sn-Glycerol-3-phosphate MSMEG_0519 conserved hypothetical protein MSMEG_0520 porin MSMEG_0521 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_0521 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_0522 pp24 protein MSMEG_0523 DNA-binding protein MSMEG_0524 short chain dehydrogenase MSMEG_0525 hypothetical protein MSMEG_0526 oxidoreductase, GMC family protein MSMEG_0527 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase MSMEG_0528 conserved hypothetical protein MSMEG_0529 probable serine/threonine-protein kinase PknK MSMEG_0530 short chain dehydrogenase MSMEG_0531 putative acyl-CoA dehydrogenase MSMEG_0532 transcriptional regulator, TetR family protein MSMEG_0533 gp236 protein MSMEG_0534 permease, major facilitator family protein MSMEG_0535 GntR-family protein transcriptional regulator MSMEG_0536 intracellular protease, PfpI family protein MSMEG_0537 conserved hypothetical protein MSMEG_0537 conserved hypothetical protein MSMEG_0538 regulatory protein, MarR MSMEG_0539 transcriptional regulator, Crp/Fnr family protein MSMEG_0540 transcriptional regulator, putative MSMEG_0541 hypothetical protein MSMEG_0542 antar domain protein MSMEG_0543 conserved hypothetical protein MSMEG_0544 transcriptional regulator

1.09

5.43E-01

0.98

8.79E-01

0.93

5.65E-01

1.35

2.64E-01

1.56

1.56E-01

0.95

5.81E-01

1.77 1.69 1.78

9.34E-02 2.62E-04 6.32E-03

0.87 1.24 0.99

1.72E-01 2.75E-01 9.54E-01

2.05 1.18 0.44

3.63E-01 2.96E-01 4.93E-02

1.25

3.33E-02

1.28

2.27E-01

1.48

1.17E-01

1.04 1.33 1.31 1.39 1.16 1.20

7.55E-01 2.78E-01 1.22E-01 1.11E-01 2.45E-01 3.64E-01

1.13 1.25 0.94 1.02 1.28 1.08

4.27E-01 3.10E-01 7.80E-01 6.16E-01 6.15E-02 3.60E-01

1.00 1.01 0.92 1.24 0.88 1.38

9.91E-01 5.74E-01 2.71E-01 3.94E-01 3.05E-01 7.67E-02

1.30 1.96 4.34 2.66 0.36 0.47 8.36 1.23 0.56 3.81 3.62 2.62 2.29 0.93 1.26 1.71 1.22 1.65 1.50


1.22 1.20 0.62 0.52 0.85 1.16 0.44 1.15 1.29 1.62 0.74 0.87 0.97 0.70 0.73 0.98 1.02 1.10 0.81


0.91 1.09 2.96 2.42 1.41 1.52 0.73 1.47 1.55 0.43 0.72 0.86 1.11 0.30 1.38 0.34 0.55 0.69 1.21



transcriptional regulator, LuxR family protein conserved hypothetical protein ISMsm5, transposase chromosome replication initiation inhibitor protein ABC transporter, permease protein sulfonate binding protein ABC nitrate/sulfonate/bicarbonate transporter, ATPase subunit conserved hypothetical protein probable sugar ABC transporter, substratebinding protein, putative ABC transporter permease protein, putative ABC transporter permease protein ABC transporter, nucleotide binding/ATPase protein hypothetical protein conserved hypothetical protein conserved domain protein dihydrodipicolinate reductase, N-terminus domain protein putative TetR family protein receptor protein conserved hypothetical protein hypothetical protein xanthine/uracil permease putative glycosyl transferases group 1 aliphatic amidase selenophosphate synthetase radical SAM domain protein flavoprotein involved in K+ transport conserved hypothetical protein hydrolase, carbon-nitrogen family protein conserved hypothetical protein putative ECF sigma factor RpoE1 putative ECF sigma factor RpoE1 MmpS1 protein MmpL4 protein major facilitator superfamily protein, putative

dapB

1.68 0.56 1.09

8.89E-02 1.33E-02 3.19E-01

0.87 1.36 0.88

9.75E-02 2.51E-01 1.43E-01

0.90 0.87 0.54

2.47E-01 3.51E-01 2.64E-05

0.96 0.69 0.69

7.89E-01 3.04E-03 1.55E-02

0.98 1.07 1.29

6.19E-01 8.26E-01 3.72E-01

4.40 3.99 1.73

3.10E-02 1.65E-01 2.89E-01

0.73 0.39

6.29E-02 3.72E-05

1.47 1.10

2.07E-01 3.14E-01

3.27 0.94

1.88E-01 6.06E-01

0.80 0.95 1.14

5.55E-02 7.19E-01 1.16E-01

4.56 1.24 1.48

1.18E-01 2.21E-01 5.04E-02

1.45 1.05 1.00

1.77E-01 3.88E-01 9.68E-01

1.22 2.37 2.50 1.32

2.29E-01 2.11E-04 4.85E-03 2.81E-02

1.17 0.71 0.92 0.74

2.22E-01 7.90E-02 7.20E-01 3.69E-01

1.01 1.03 1.46 1.35

9.47E-01 8.46E-01 2.37E-01 3.17E-01

1.57 0.67 0.74 0.57 0.42 0.91 0.65 0.21 0.24 0.09 0.12 0.11 0.09 1.18 2.25 1.57 1.07 1.06

8.91E-02 4.93E-03 5.21E-02 1.01E-03 1.12E-04 6.43E-01 1.06E-02 5.06E-04 1.34E-04 1.18E-05 1.02E-05 1.16E-05 7.34E-06 1.13E-01 3.47E-02 1.90E-02 6.53E-01 7.00E-01

1.13 0.84 0.91 1.31 0.94 1.14 1.29 1.46 1.59 4.04 1.31 1.78 3.02 1.00 0.92 1.03 0.97 1.43


0.78 1.47 1.08 1.00 1.36 1.52 1.06 0.87 1.73 0.65 0.87 0.64 0.55 2.01 1.04 0.90 1.27 1.28


MSMEG_0578 MSMEG_0579 MSMEG_0580 MSMEG_0581 MSMEG_0582 MSMEG_0583 MSMEG_0584 MSMEG_0585 MSMEG_0586 MSMEG_0587 MSMEG_0588 MSMEG_0589 MSMEG_0590 MSMEG_0591 MSMEG_0592 MSMEG_0593 MSMEG_0594 MSMEG_0595 MSMEG_0596 MSMEG_0597 MSMEG_0598 MSMEG_0599 MSMEG_0600 MSMEG_0601 MSMEG_0602 MSMEG_0603 MSMEG_0604 MSMEG_0605 MSMEG_0606 MSMEG_0607 MSMEG_0608 MSMEG_0609 MSMEG_0610 MSMEG_0611

acyl-CoA dehydrogenase, middle domain protein helix-turn-helix, Fis-type conserved hypothetical protein 4-aminobutyrate transaminase succinic semialdehyde dehydrogenase probable membrane protein hypothetical protein L-carnitine dehydratase/bile acid-inducible protein F stas domain, putative L-rhamnose 1-epimerase putative rhamnose tranport protein, MFS family protein L-rhamnose isomerase rhamnulose-1-phosphate aldolase/alcohol dehydrogenase rhamnulokinase putative rhamnose catabolism operon transcriptional regulator conserved hypothetical protein iron-sulfur cluster binding protein glycolate oxidase bacterial regulatory protein, GntR family protein conserved hypothetical protein hypothetical protein acyl-CoA synthase dehydrogenase conserved hypothetical protein hypothetical protein putative acyl-CoA dehydrogenase glyoxylate reductase conserved hypothetical protein transcriptional regulator, TetR family protein methyltransferase, putative, family protein glyoxalase family protein helix-turn-helix domain protein beta-lactamase para-nitrobenzyl esterase

1.26 0.72 0.81 0.94 0.87 6.94 1.61

2.21E-01 1.07E-01 1.20E-01 5.62E-01 7.01E-02 1.30E-01 9.10E-02

1.69 1.52 0.86 1.04 0.96 0.85 1.09

4.89E-02 2.16E-01 1.21E-01 8.39E-01 9.29E-02 2.15E-02 7.03E-01

1.07 1.10 0.98 1.12 1.06 0.85 0.46

4.16E-01 3.09E-01 7.22E-01 5.10E-01 5.44E-01 1.81E-01 5.53E-03

rhaU

1.64 1.26 1.31

1.46E-02 2.70E-01 1.67E-02

0.92 1.05 1.39

3.20E-01 8.10E-01 1.16E-01

0.98 0.46 1.70

1.46E-01 1.90E-03 4.74E-02

rhaI

1.24 1.42

2.97E-01 1.61E-01

1.02 1.06

8.37E-01 4.05E-01

0.95 0.91

6.93E-01 3.38E-01

rhaD rhaB

1.59 0.97

1.26E-02 6.37E-01

0.83 1.04

2.25E-01 7.94E-01

1.07 1.12

7.52E-01 3.89E-01

0.77 2.13 1.13 2.11 1.04 2.08 1.17 1.15 0.75 2.26 4.82 4.14 1.71 2.30 1.00 0.93 1.29 1.33 1.30 1.25


0.84 0.87 0.87 0.84 1.13 1.48 0.85 0.90 1.27 2.09 1.64 0.76 0.80 0.68 1.01 0.93 1.08 0.91 1.14 1.22


1.84 1.37 1.59 0.95 1.06 0.88 1.00 0.18 0.87 1.27 0.74 0.16 1.12 3.95 1.06 0.95 0.63 1.01 1.12 1.05


gabT

MSMEG_0612 MSMEG_0613 MSMEG_0614 MSMEG_0615 MSMEG_0616 MSMEG_0617 MSMEG_0618 MSMEG_0619 MSMEG_0620 MSMEG_0621 MSMEG_0622 MSMEG_0623 MSMEG_0624 MSMEG_0625 MSMEG_0626 MSMEG_0627 MSMEG_0628 MSMEG_0629 MSMEG_0630 MSMEG_0631

MSMEG_0632 MSMEG_0633 MSMEG_0634 MSMEG_0635 MSMEG_0636 MSMEG_0637 MSMEG_0638 MSMEG_0639 MSMEG_0640

transcriptional regulator, TetR family protein conserved hypothetical protein methyltransferase ATPase, AAA family protein conserved hypothetical protein ftsk/spoiiie family protein pe family protein ppe family protein pe family protein low molecular weight protein antigen 7 putative DNA-binding protein snm secretion protein Snm4 subtilase family protein conserved hypothetical protein conserved hypothetical protein glycosyl transferase, family protein 39 amidohydrolase family protein trans-aconitate 2-methyltransferase conserved hypothetical protein sulfatase family protein, authentic frameshift; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00884 conserved hypothetical protein PAP2 superfamily protein PAP2 superfamily protein putative conserved exported protein conserved hypothetical protein iron-sulfur binding oxidoreductase conserved hypothetical proline and threonine rich protein oligopeptide transport ATP-binding protein AppF oligopeptide transport ATP-binding protein OppD

MSMEG_0641 binding-protein-dependent transport systems inner membrane component MSMEG_0642 hypothetical ABC transporter permease protein YliD

1.38 1.82 1.03 0.33 0.37 0.30 0.38 0.44 0.46 0.50 0.35 0.33 0.32 0.94 0.28 0.87 0.34 0.91 0.93


1.00 0.74 0.78 1.27 1.43 0.96 1.11 0.95 1.08 0.98 1.13 1.06 1.07 0.73 1.28 0.74 1.05 1.00 1.02


0.95 0.61 2.24 2.48 2.22 3.26 1.92 2.08 0.91 1.20 1.54 2.40 2.47 1.09 3.28 0.87 1.24 1.02 1.02


1.15 1.03 0.89 0.75 1.11 0.65 1.45

1.95E-01 7.36E-01 8.66E-02 1.90E-02 7.24E-01 9.68E-03 4.50E-01

1.41 0.75 1.01 1.07 0.88 1.26 1.17

4.45E-01 7.44E-05 8.76E-01 3.17E-01 4.68E-01 9.10E-02 9.17E-03

3.38 1.91 1.15 1.14 0.97 0.65 0.89

2.95E-01 2.39E-03 1.32E-01 4.21E-01 9.36E-01 1.16E-02 2.56E-01

0.84 0.47

3.68E-01 1.79E-04

0.85 1.08

3.26E-01 5.25E-01

1.70 0.60

2.05E-01 1.15E-02

0.99

9.07E-01

1.13

2.34E-01

0.48

2.19E-04

0.68

5.85E-02

1.06

7.19E-01

0.32

4.13E-05

1.05

6.07E-01

1.65

9.39E-02

0.32

3.20E-05

MSMEG_0643 extracellular solute-binding protein, family protein 5, putative MSMEG_0644 cupin domain protein MSMEG_0645 putative beta-1,3-glucanase MSMEG_0646 putative transporter MSMEG_0647 phosphonate ABC transporter, ATP-binding protein MSMEG_0648 hypothetical protein MSMEG_0649 phosphonate-binding periplasmic protein MSMEG_0650 GntR-family protein transcriptional regulator MSMEG_0651 putative conserved exported protein MSMEG_0652 hypothetical protein MSMEG_0653 hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative MSMEG_0654 conserved hypothetical protein MSMEG_0655 glucose 1-dehydrogenase, putative MSMEG_0656 transcriptional regulator, TetR family protein MSMEG_0657 Rieske 2Fe-2S domain protein MSMEG_0658 polyamine ABC-transporter, inner membrane subunit MSMEG_0659 polyamine ABC transporter permease protein MSMEG_0660 Bacterial extracellular solute-binding protein MSMEG_0661 glutamate-1-semialdehyde 2,1-aminomutase MSMEG_0662 putrescine transport ATP-binding protein PotG MSMEG_0663 TetR-family protein transcriptional regulator MSMEG_0664 FAD dependent oxidoreductase MSMEG_0665 sarcosine oxidase subunit beta, putative MSMEG_0666 acetyl-CoA synthetase, putative MSMEG_0667 butyryl-CoA dehydrogenase MSMEG_0668 integral membrane protein MSMEG_0669 hypothetical protein MSMEG_0670 FAD dependent oxidoreductase MSMEG_0671 S-(hydroxymethyl)glutathione dehydrogenase MSMEG_0672 conserved hypothetical protein MSMEG_0673 hypothetical protein MSMEG_0674 ErfK/YbiS/YcfS/YnhG family protein MSMEG_0675 putative cytochrome P450 144

phnC

0.85 0.26 0.42 1.10

2.80E-01 8.41E-06 8.54E-06 2.72E-01

1.01 1.22 0.88 1.09

9.22E-01 1.45E-01 1.75E-01 6.53E-01

0.30 0.97 0.52 0.85

4.44E-05 5.69E-01 2.58E-02 7.78E-02

1.07 1.23 1.61 1.32 2.04 1.09

5.67E-01 3.45E-02 1.02E-01 2.49E-01 7.53E-02 5.59E-01

0.87 1.14 0.93 1.30 1.28 1.01

3.59E-01 1.70E-01 7.48E-01 1.11E-02 5.13E-01 8.45E-01

1.07 1.30 1.06 0.93 0.70 1.72

2.80E-01 1.47E-01 1.92E-01 2.42E-01 7.20E-02 5.73E-02

1.01 2.24 1.14 1.67 4.14

9.31E-01 6.63E-02 3.08E-01 1.35E-03 1.17E-02

1.19 0.82 0.96 0.76 0.69

2.05E-01 6.15E-02 6.94E-01 3.02E-02 3.24E-02

0.95 0.99 1.09 1.05 0.96

4.19E-01 7.91E-01 4.83E-01 7.64E-01 8.13E-01

1.22 2.15 7.82 4.99 2.72 1.37 4.31 3.40 1.22 1.68 1.56 1.23 0.72 1.23 1.70 1.04 1.61 2.06


0.95 0.91 0.88 0.76 1.16 0.89 0.86 0.76 1.04 0.79 0.77 1.09 1.39 2.63 2.75 0.75 0.63 0.79


0.92 0.96 0.30 0.83 0.91 1.51 0.78 0.46 1.15 1.06 0.90 0.73 1.12 0.59 0.30 1.27 1.01 1.02



putative transcriptional regulatory protein dcd deoxycytidine triphosphate deaminase conserved hypothetical protein UDP-glucose 6-dehydrogenase P450 heme-thiolate protein conserved hypothetical protein, putative conserved hypothetical protein aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding oxidoreductase, molybdopterin-binding subunit oxidoreductase conserved hypothetical protein aspartate aminotransferase hypothetical protein iron-sulfur cluster-binding protein putative transcriptional regulatory protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error isoniazid inductible protein IniA alanine-rich protein integral membrane protein isoniazid inductible protein IniC conserved hypothetical proline rich protein hypothetical protein hypothetical protein monooxygenase conserved hypothetical protein LpqJ protein putative permease of the major facilitator superfamily protein 4-carboxy-4-hydroxy-2-oxoadipate aldolase conserved hypothetical protein transcriptional regulator, LysR family protein dnaK chaperone protein DnaK grpE co-chaperone GrpE

1.08 0.57 1.68 1.17 1.76 2.51 1.50

4.80E-01 5.71E-04 3.55E-03 4.01E-01 6.57E-03 1.72E-02 1.09E-03

0.99 0.94 0.80 2.68 0.88 1.05 0.75

9.41E-01 7.54E-01 1.65E-02 1.29E-01 1.06E-01 4.94E-01 2.31E-02

2.23 1.13 1.24 1.04 0.75 0.25 0.56

6.59E-02 6.17E-01 4.38E-01 2.24E-01 1.01E-01 8.96E-05 1.09E-02

1.05 1.32 1.01 0.42 0.63 3.68 0.54 0.54 0.50 2.07

8.96E-01 4.47E-01 9.03E-01 2.00E-04 2.15E-03 1.03E-03 1.96E-04 4.31E-04 3.76E-04 8.30E-06

1.91 2.34 0.84 0.97 1.02 0.35 0.91 0.87 0.94 0.58

8.53E-03 5.25E-02 2.14E-02 6.18E-01 8.66E-01 1.50E-04 2.94E-01 1.09E-01 3.43E-01 8.50E-03

0.81 0.58 0.64 1.31 0.90 0.48 3.69 2.05 1.52 1.16

2.06E-01 1.36E-01 2.43E-04 5.81E-01 2.70E-01 6.10E-02 7.97E-03 1.69E-02 5.68E-02 2.57E-01

2.28 1.31 1.55 1.77 0.69 2.32 0.63 1.10 1.09 2.03 0.99

5.88E-05 7.11E-03 2.48E-01 4.47E-01 1.40E-02 1.28E-02 3.40E-02 5.30E-01 2.26E-01 2.21E-03 9.79E-01

0.44 0.59 1.43 2.18 0.96 0.61 1.21 1.15 0.69 0.74 0.73

6.69E-03 7.47E-03 6.44E-02 5.40E-03 5.49E-01 2.51E-03 1.86E-01 3.54E-01 3.14E-02 2.07E-02 3.95E-02

0.70 1.15 0.54 0.52 1.48 3.42 0.99 1.10 0.97 1.48 2.54

1.28E-01 3.75E-01 3.59E-02 5.85E-02 7.96E-02 8.74E-02 9.65E-01 4.84E-01 5.51E-01 1.41E-01 8.86E-02

1.23 0.88 1.26 0.89 1.35 1.38

6.23E-02 5.33E-01 3.65E-01 2.39E-01 4.73E-02 5.79E-02

1.56 0.93 1.10 0.91 2.33 1.36

4.52E-01 5.44E-01 5.07E-01 1.70E-01 8.73E-02 1.91E-01

1.73 1.06 1.19 1.27 1.40 1.40

3.96E-01 6.92E-01 1.94E-01 5.10E-01 1.70E-01 1.80E-01

MSMEG_0711 MSMEG_0712 MSMEG_0713 MSMEG_0714 MSMEG_0715 MSMEG_0716 MSMEG_0717 MSMEG_0718 MSMEG_0719 MSMEG_0720 MSMEG_0721 MSMEG_0721 MSMEG_0722 MSMEG_0723 MSMEG_0725 MSMEG_0726 MSMEG_0727 MSMEG_0728 MSMEG_0729 MSMEG_0730 MSMEG_0731 MSMEG_0732 MSMEG_0733 MSMEG_0734 MSMEG_0735 MSMEG_0736 MSMEG_0737 MSMEG_0738 MSMEG_0739 MSMEG_0740 MSMEG_0741 MSMEG_0742 MSMEG_0743 MSMEG_0744 MSMEG_0745

chaperone protein DnaJ transcriptional regulator, TetR family protein transcriptional regulator, MerR family protein acyl-CoA dehydrogenase 3-oxoacyl-[acyl-carrier-protein] reductase major facilitator superfamily protein aldose 1-epimerase subfamily protein acetyl-CoA synthetase flavohemoprotein integral membrane protein RemQ protein; this gene contains a frame shift which is not the result of sequencing error RemQ protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein conserved hypothetical protein IS1137, transposase orfB hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein oleandomycin glycosyltransferase conserved hypothetical protein chaperone ClpB dihydrodipicolinate reductase, N-terminus domain protein Rieske [2Fe-2S] domain protein putative transcriptional regulator conserved hypothetical protein dehydrogenase conserved hypothetical protein spou rRNA methylase family protein glycosyl hydrolase family protein 76 conserved hypothetical protein probable transcriptional regulatory protein xanthine dehydrogenase carbon monoxide dehydrogenase medium chain [2Fe-2S] binding domain protein

dnaJ

dapB

1.19 0.53 0.94 1.51 1.43 1.97 0.93 1.14 0.57 1.28

1.46E-02 5.83E-04 4.23E-01 2.28E-01 4.83E-02 1.12E-02 2.82E-01 2.62E-01 6.55E-03 3.11E-02

1.60 0.99 3.08 1.03 1.11 5.00 0.97 4.08 0.96 0.85

1.52E-01 9.33E-01 1.35E-01 7.51E-01 5.44E-01 1.09E-01 8.64E-01 6.34E-02 7.10E-01 7.38E-02

1.77 1.19 1.70 0.52 1.06 0.88 0.56 0.96 1.74 1.22

3.80E-02 5.37E-01 5.85E-02 2.28E-03 3.75E-01 6.25E-01 8.55E-04 7.52E-01 4.51E-02 2.71E-01

0.90

3.07E-01

2.64

9.73E-02

0.84

1.85E-01

1.10 1.30 0.93 0.68 0.91 0.39 1.39 0.69 0.79 1.03 2.36

4.84E-01 2.16E-01 2.99E-01 9.44E-02 2.59E-01 1.54E-04 8.03E-02 3.46E-02 1.56E-01 8.19E-01 2.25E-03

1.96 1.04 0.97 1.82 1.08 1.05 0.93 1.01 1.08 1.17 5.78

1.63E-01 7.94E-01 7.21E-01 2.38E-01 4.35E-01 7.87E-01 4.49E-01 9.60E-01 6.95E-01 4.72E-01 9.70E-02

0.99 1.04 1.25 1.22 0.51 0.94 0.49 1.13 1.07 1.31 1.39

6.46E-01 1.62E-01 4.47E-02 4.31E-01 4.99E-02 2.69E-01 2.80E-02 2.72E-01 4.92E-01 4.94E-01 1.70E-02

0.90 1.08 0.89 0.84 0.76 0.30 0.36 0.78 0.93 1.51 1.78 8.47 3.44

8.67E-02 5.26E-01 4.27E-01 2.32E-02 1.61E-02 2.62E-05 2.37E-05 5.36E-03 3.71E-01 4.43E-03 1.82E-02 1.50E-02 5.02E-04

1.44 1.36 15.15 0.97 2.19 4.15 5.52 2.21 2.01 0.78 1.43 2.40 1.89

1.81E-01 4.22E-02 7.79E-02 7.49E-01 1.16E-01 1.01E-01 1.01E-01 1.21E-01 1.73E-01 7.27E-03 1.25E-01 6.61E-02 8.01E-02

0.63 0.64 0.97 0.96 1.53 1.97 2.26 1.11 1.05 1.61 1.02 0.15 0.33

4.41E-02 8.11E-02 6.98E-01 6.96E-01 2.65E-03 1.65E-02 8.68E-03 8.30E-02 8.41E-01 3.30E-02 8.42E-01 4.17E-05 6.18E-04

MSMEG_0746 carbon-monoxide dehydrogenase, large subunit MSMEG_0747 carbon monoxide dehydrogenase F protein MSMEG_0748 ATPase associated with various cellular activities, AAA_5 MSMEG_0749 carbon monoxide dehydrogenase subunit G (CoxG) family protein MSMEG_0750 membrane protein MSMEG_0751 conserved hypothetical protein MSMEG_0752 fructose-bisphosphate aldolase, class II MSMEG_0753 conserved hypothetical protein MSMEG_0754 conserved hypothetical protein MSMEG_0755 cobalt-zinc-cadmium resistance protein MSMEG_0756 peptidase, M50B family protein MSMEG_0757 hypothetical protein MSMEG_0758 conserved hypothetical protein MSMEG_0759 adenylosuccinate synthetase MSMEG_0760 thioesterase family protein MSMEG_0761 conserved domain protein MSMEG_0762 cytochrome P450 FAS1 MSMEG_0763 antibiotic transporter MSMEG_0764 Na+/H+ antiporter MSMEG_0765 zinc finger, UBP-type MSMEG_0766 phosphoribosylglycinamide formyltransferase 2 MSMEG_0767 hypothetical protein MSMEG_0768 conserved hypothetical protein MSMEG_0769 O-succinylhomoserine sulfhydrylase MSMEG_0770 hypothetical protein MSMEG_0771 hypothetical oxidoreductase YqjQ MSMEG_0772 phytase MSMEG_0773 acetyltransferase MSMEG_0774 flavin-dependent oxidoreductase; this gene contains a frame shift which is not the result of sequencing error MSMEG_0775 metallo-beta-lactamase superfamily protein MSMEG_0776 conserved hypothetical protein MSMEG_0777 F420-dependent glucose-6-phosphate dehydrogenase MSMEG_0778 putative transcriptional regulator

fbaA

purA

purT metZ

6.92 5.77

5.79E-03 1.14E-02

2.10 1.89

6.51E-02 1.29E-01

0.21 0.53

2.40E-06 7.52E-03

2.32

1.30E-02

3.10

9.54E-02

0.85

1.76E-01

1.98 0.76 1.22 1.40 0.89 1.05 3.31 0.60 0.81 0.65 1.05 0.67 2.61 2.92 0.83 0.46 1.03 0.74 0.48 0.61 0.51 0.43 1.68 1.18 3.12


1.65 0.95 2.86 1.29 0.84 0.98 0.75 0.93 5.38 1.14 0.78 1.37 0.65 0.70 1.25 1.21 1.09 0.99 1.41 1.02 1.11 1.15 0.84 1.09 1.70


0.92 1.11 0.97 0.83 0.55 4.95 0.76 0.84 2.01 1.34 1.10 21.39 0.91 0.81 1.32 1.05 0.79 1.96 2.08 2.07 2.24 2.06 0.81 1.21 1.20


3.54 1.34 1.05

1.02E-02 4.67E-02 5.69E-01

1.40 0.96 1.15

2.95E-01 6.33E-01 2.28E-01

0.89 0.50 5.13

1.71E-01 7.90E-04 2.98E-02

0.95 0.93

3.25E-01 2.70E-01

0.97 1.05

7.48E-01 4.88E-02

0.73 1.03

7.47E-03 7.36E-01


short-chain dehydrogenase/reductase SDR phosphotransferase enzyme family protein amino acid permease aminotransferase class-III phosphate acetyltransferase acetate kinase conserved hypothetical protein serine/threonine protein kinase Bacterial extracellular solute-binding protein, family protein 3 putative conserved membrane protein thiamine-phosphate pyrophosphorylase hydrolase, NUDIX family protein glycine oxidase ThiO thiamine biosynthesis protein ThiS thiazole biosynthesis protein ThiG conserved hypothetical protein ABC transporter ATP-binding protein ABC transporter integral membrane subunit conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein hydrolase leupeptin-inactivating enzyme 1 possible chalcone synthase Pks10 isoprenylcysteine carboxyl methyltransferase putative pyrimidine permease RutG oxidoreductase

pta ackA

thiE thiO thiS thiG

0.18 1.01 0.22 0.36 0.89 0.68 0.75 1.91

7.98E-05 9.17E-01 1.07E-04 1.07E-02 1.95E-01 8.33E-03 4.57E-02 2.10E-02

0.92 0.92 0.98 1.55 1.22 1.34 1.40 0.85

5.57E-01 2.05E-01 7.62E-01 1.88E-01 5.62E-02 1.08E-01 3.38E-01 3.65E-02

0.81 1.07 1.00 1.10 2.98 2.32 1.01 3.93

8.60E-02 8.42E-01 9.77E-01 4.82E-01 1.94E-03 1.49E-01 9.40E-01 1.46E-04

1.57 1.96 0.48 1.07 1.19 1.21 1.01 0.55 0.80 0.96

6.17E-02 6.81E-03 5.85E-04 2.43E-01 3.09E-02 5.52E-03 8.35E-01 9.63E-04 1.18E-01 3.44E-01

0.70 0.85 0.87 0.80 0.66 0.65 0.78 0.95 0.78 1.01

9.48E-03 2.77E-02 2.20E-01 9.14E-02 1.90E-02 4.62E-03 1.64E-02 5.76E-01 9.72E-02 9.16E-01

5.10 2.85 0.75 0.99 1.17 0.85 1.03 1.28 1.95 1.11

1.76E-02 2.39E-02 2.01E-01 9.65E-01 2.98E-01 3.20E-01 8.69E-01 1.43E-01 9.60E-03 5.39E-01

0.85

6.80E-02

1.22

3.92E-02

1.26

1.56E-01

1.27 1.14 1.18 0.90 1.92 0.95 1.13 0.62 0.68 0.38 1.74 1.19 0.74 1.11

4.64E-01 4.50E-01 2.37E-02 1.11E-01 5.12E-02 5.96E-01 2.16E-01 6.92E-04 5.70E-02 9.23E-04 2.73E-01 2.21E-01 5.79E-03 5.50E-01

0.96 0.99 0.74 0.79 0.61 1.10 1.09 1.07 0.95 1.13 1.20 2.18 0.86 1.31

6.06E-01 8.95E-01 3.21E-03 6.38E-02 4.37E-02 4.36E-01 3.56E-01 5.90E-01 8.32E-01 1.78E-01 2.83E-01 2.92E-01 1.54E-01 2.03E-01

0.94 1.24 0.33 1.15 1.44 0.94 1.23 1.11 1.29 2.01 1.01 1.09 0.89 0.98

6.97E-01 5.36E-01 1.31E-04 5.36E-01 1.97E-01 6.89E-01 3.49E-01 1.77E-01 6.13E-03 2.24E-02 9.48E-01 5.82E-01 6.47E-01 8.01E-01


amino acid transporter conserved hypothetical protein membrane protein transcriptional regulator, TetR family protein flavin-binding monooxygenase LysR-family protein transcriptional regulator transporter, major facilitator family protein N-carbamoyl-L-amino acid amidohydrolase conserved hypothetical protein glutamyl-tRNA(Gln) amidotransferase subunit A cytochrome P450 conserved hypothetical protein conserved hypothetical protein phosphomethylpyrimidine kinase thiamine biosynthesis protein ThiC major facilitator superfamily protein MFS_1 immunogenic protein MPT63 exodeoxyribonuclease III acetyltransferase, gnat family protein short chain dehydrogenase peptide deformylase conserved hypothetical protein tuberculin related peptide copper/zinc superoxide dismutase carboxylate-amine ligase hypothetical protein AsnC-family protein transcriptional regulator ATP-dependent protease La (LON) domain subfamily protein hypothetical protein hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative hypothetical protein multisubunit Na+/H+ antiporter, G subunit multiple resistance and pH regulation protein F multisubunit Na+/H+ antiporter

thiD thiC xth def sodC

1.18 1.53 1.08 1.66 2.93 1.17 1.80 1.09 11.59 1.30 5.76 0.66 0.65 0.60 0.81 1.09 2.52 0.47 0.47 1.26 0.44 0.86 0.59 0.43 0.30 0.74 0.63

2.93E-01 2.64E-02 4.75E-01 4.44E-04 4.60E-04 5.62E-01 1.14E-02 6.50E-01 6.16E-02 1.98E-01 3.95E-02 2.74E-03 1.01E-03 2.88E-03 7.90E-02 8.09E-01 6.71E-03 5.59E-03 5.97E-03 2.39E-01 1.59E-04 2.53E-01 1.83E-03 1.91E-06 2.19E-05 3.62E-01 9.49E-06

0.94 0.91 0.79 0.96 0.71 1.11 0.85 0.95 0.56 0.95 0.65 0.97 0.85 0.63 0.72 1.91 0.83 0.92 1.15 1.34 1.05 1.12 0.96 0.83 1.29 1.08 0.90


1.10 1.93 1.45 0.99 1.02 0.94 1.31 0.94 0.92 1.00 0.59 1.29 0.56 0.48 0.52 1.18 0.36 1.26 1.36 1.23 1.13 1.27 1.58 1.22 2.46 1.38 1.38


1.68 0.42

7.83E-03 1.19E-05

0.88 1.13

3.01E-01 1.87E-01

0.96 0.47

7.14E-01 3.39E-05

0.72 0.73 0.71 0.63 0.61

5.99E-03 1.74E-03 8.06E-05 4.29E-06 1.79E-04

1.01 1.20 0.80 0.93 0.86

7.97E-01 2.01E-01 3.17E-02 5.61E-01 5.10E-02

0.47 0.46 0.92 0.80 1.19

1.62E-04 1.54E-02 3.79E-01 2.57E-01 2.99E-01

MSMEG_0846 NADH-ubiquinone oxidoreductase/multisubunit na+/h+ antiporter, d subunit MSMEG_0847 NADH-ubiquinone/plastoquinone oxidoreductase chain 4l family protein MSMEG_0848 NADH ubiquinone oxidoreductase subunit 5 MSMEG_0849 oxygenase MSMEG_0850 conserved hypothetical protein MSMEG_0851 Citrate transporter MSMEG_0852 CBS domain protein MSMEG_0853 conserved hypothetical protein MSMEG_0854 two-component system sensor kinase MSMEG_0855 conserved hypothetical protein MSMEG_0856 DNA-binding response regulator, LuxR family protein MSMEG_0857 conserved hypothetical protein MSMEG_0858 cell division control protein Cdc48 MSMEG_0859 transcriptional regulator, TetR family protein MSMEG_0860 CDP-diacylglycerol--serine Ophosphatidyltransferase psd MSMEG_0861 phosphatidylserine decarboxylase MSMEG_0862 molybdopterin biosynthesis protein MoeA MSMEG_0863 short chain dehydrogenase MSMEG_0864 bacterial membrane flanked domain family MSMEG_0865 bacterial membrane flanked domain family MSMEG_0866 DNA or RNA helicase of superfamily protein II MSMEG_0867 hydrolase MSMEG_0868 hypothetical protein MSMEG_0869 hypothetical protein MSMEG_0870 oxidoreductase MSMEG_0871 putative aldehyde or xanthine dehydrogenase, molybdopterin binding subunit protein MSMEG_0872 twin-arginine translocation pathway signal MSMEG_0873 hypothetical protein MSMEG_0874 transcriptional regulator, GntR family protein MSMEG_0875 putative sialic acid transporter MSMEG_0876 short chain dehydrogenase MSMEG_0877 dihydrodipicolinate synthase MSMEG_0878 transcriptional regulator

0.46

2.78E-07

0.70

4.25E-02

1.66

1.20E-01

0.60 0.65 0.94 1.08 6.63 1.77 3.03 3.82 1.14

6.05E-05 2.95E-03 4.07E-01 4.93E-01 3.87E-01 2.67E-02 3.24E-03 3.40E-03 3.34E-01

0.88 0.95 1.15 1.29 1.04 1.03 1.37 0.89 0.80

1.96E-01 6.18E-01 4.17E-01 2.79E-01 3.34E-01 8.87E-01 3.58E-01 2.16E-01 9.27E-02

1.19 1.08 1.07 0.91 1.04 1.09 1.40 1.04 1.03

9.76E-02 4.19E-01 5.00E-01 4.48E-01 6.69E-01 3.62E-01 6.80E-02 7.88E-01 6.02E-01

3.17 0.48 0.70 0.93

4.96E-04 2.85E-03 5.52E-03 4.64E-01

0.96 0.80 1.11 0.77

6.71E-01 2.12E-02 2.43E-01 1.30E-02

1.13 0.93 2.16 1.33

1.02E-01 4.66E-01 8.70E-02 1.29E-01

0.67 0.64 0.59 0.75 0.56 1.06 0.79 0.80 1.22 1.01 2.27

2.08E-04 6.65E-04 8.25E-05 2.41E-03 1.52E-05 6.28E-01 2.31E-02 8.40E-03 1.60E-01 8.88E-01 2.46E-01

0.83 1.04 0.85 0.94 0.90 0.93 0.79 0.93 1.19 1.15 1.02

8.61E-02 6.72E-01 8.64E-02 2.59E-01 2.84E-01 5.43E-01 1.31E-01 4.86E-01 1.65E-01 3.15E-01 8.80E-01

1.26 1.57 0.83 0.57 0.95 1.00 2.20 1.18 1.05 1.00 1.06

1.29E-01 1.82E-02 1.76E-01 2.98E-03 6.73E-01 9.63E-01 3.77E-02 1.35E-01 3.01E-01 9.38E-01 3.57E-01

2.54 1.77 1.12 0.77 1.49 0.83 1.20 1.51

3.88E-01 2.35E-01 2.09E-01 1.83E-02 1.36E-03 7.31E-02 1.49E-01 3.34E-02

0.89 0.89 1.05 0.96 0.64 0.84 0.70 0.75

5.78E-01 4.05E-01 6.13E-01 5.25E-01 1.63E-04 3.45E-01 5.13E-03 1.64E-01

1.15 1.01 1.00 1.44 1.57 0.58 1.38 0.77

2.17E-02 3.92E-02 8.69E-01 2.39E-01 4.26E-01 8.34E-03 1.59E-01 5.40E-02


hypothetical protein chaperonin GroL conserved hypothetical protein conserved hypothetical protein amidohydrolase family protein glyoxalase family protein conserved hypothetical protein serine/threonine-protein kinase PknD conserved hypothetical protein conserved hypothetical protein succinic semialdehyde dehydrogenase HD domain protein polyphosphate kinase 2 conserved hypothetical protein hypothetical protein dihydrodipicolinate reductase bacterial regulatory protein, GntR family protein integral membrane transport protein conserved hypothetical protein tagatose-1,6-bisphosphate aldolase GatY prolyl oligopeptidase family protein eptc-inducible aldehyde dehydrogenase conserved hypothetical protein cyclopropane-fatty-acyl-phospholipid synthase 1 dihydrolipoamide dehydrogenase probable conserved membrane protein 4-carboxymuconolactone decarboxylase domain protein DNA-binding protein conserved hypothetical protein hypothetical protein acyl-ACP thioesterase superfamily protein hypothetical protein isocitrate lyase 3-hydroxybutyryl-CoA dehydrogenase methoxy mycolic acid synthase 1 conserved hypothetical protein polyphosphate kinase 2 superfamily protein

groL

lpdA pcaC

aceA

0.85 0.62 0.57 2.04 1.65 0.91 2.22 2.08 1.47 0.85 1.63 0.78 0.67 0.61 1.23 1.79 1.23 1.25 1.27 1.22 0.64 2.83 1.45 0.94 0.45 0.27

2.19E-01 7.12E-04 7.99E-04 7.14E-05 3.16E-03 5.92E-01 4.33E-02 6.93E-04 2.77E-03 7.99E-02 1.47E-02 1.69E-03 4.40E-02 1.83E-03 3.18E-02 7.57E-03 5.37E-04 1.89E-02 2.27E-02 2.12E-02 1.18E-04 3.24E-03 2.32E-02 3.47E-01 5.17E-04 4.02E-06

0.76 0.84 0.87 1.09 0.91 0.92 0.90 1.19 0.74 1.09 0.89 0.90 0.96 0.84 1.01 1.07 0.77 0.85 0.80 0.84 0.81 1.07 0.90 1.19 1.14 1.06


0.99 0.41 1.19 0.42 0.87 1.37 1.03 0.82 1.15 1.91 0.16 1.08 0.95 1.08 1.08 0.50 0.92 0.97 1.39 1.41 1.60 0.20 0.30 1.20 0.71 1.55


1.22 0.53 0.83 0.86 1.07 0.99 0.25 0.50 0.83 0.73 1.15

2.47E-02 2.40E-05 2.87E-01 6.78E-02 3.22E-01 9.03E-01 4.75E-05 1.00E-03 2.40E-03 3.84E-02 2.02E-01

0.78 0.93 1.00 1.09 0.89 1.11 1.36 0.80 0.74 1.06 0.67

1.35E-02 2.06E-02 9.71E-01 2.71E-01 4.15E-01 5.82E-01 3.54E-01 5.02E-03 6.65E-02 2.86E-01 7.15E-02

0.73 0.98 1.01 0.95 1.01 1.53 1.29 0.78 0.85 1.00 1.81

6.56E-02 8.70E-01 6.62E-01 5.06E-01 9.48E-01 4.43E-01 1.26E-01 4.84E-01 1.99E-01 9.14E-01 6.90E-02


transcriptional regulator, TetR family protein conserved hypothetical protein transcriptional regulator, XRE family protein heparin-binding hemagglutinin conserved hypothetical protein conserved hypothetical protein deoxyribose-phosphate aldolase conserved hypothetical protein hydrolase, carbon-nitrogen family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein UDP-N-acetylenolpyruvoylglucosamine ErfK/YbiS/YcfS/YnhG family protein serine 3-dehydrogenase hypothetical protein ROK family protein conserved hypothetical protein conserved hypothetical protein 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase sensor histidine kinase SenX3 DNA-binding response regulator RegX3 conserved hypothetical protein Ppx/GppA phosphatase family protein conserved hypothetical protein AP endonuclease, family protein 2 conserved hypothetical protein pyrroline-5-carboxylate reductase DNA binding domain, excisionase family protein conserved domain protein NAD dependent epimerase/dehydratase family protein acyltransferase conserved hypothetical protein HAD-superfamily protein subfamily protein IB hydrolase, TIGR01490 hypothetical protein

deoC

murB

senX3 regX3

proC

2.11 1.53 1.84 1.78 1.43 0.72 0.66 0.50 1.19 0.83 1.02 0.68 0.30 0.76 0.79 1.26 0.69 1.28 0.87


0.89 0.93 0.80 0.93 0.94 0.92 0.81 0.81 0.71 1.22 0.87 1.16 0.97 0.77 0.96 0.82 1.70 1.15 0.81


0.82 0.90 1.36 1.91 0.77 1.29 1.94 1.20 1.43 1.10 1.49 1.05 1.23 1.32 1.36 0.98 12.21 1.65 1.63


0.60 1.50 1.41 0.84 1.00 0.78 0.25 0.36 0.35 1.38 0.80

6.08E-04 4.80E-02 8.29E-03 3.43E-03 9.53E-01 1.70E-03 3.61E-06 8.77E-05 9.08E-05 1.21E-03 1.41E-02

1.03 1.00 0.89 0.87 0.90 0.80 1.00 1.02 0.98 0.64 0.86

6.91E-01 9.46E-01 1.67E-01 8.53E-02 4.57E-02 1.57E-02 9.23E-01 7.60E-01 8.20E-01 1.49E-02 6.24E-02

0.82 2.04 1.84 1.56 1.23 1.47 3.24 1.76 2.00 0.71 1.31

3.63E-01 6.57E-03 4.29E-03 5.77E-04 1.72E-01 1.29E-02 4.68E-04 7.35E-02 2.34E-01 4.18E-02 4.27E-01

0.97 1.15 0.56

3.54E-01 4.22E-01 7.20E-05

0.97 0.81 1.05

4.49E-01 3.60E-02 6.12E-01

0.83 0.94 1.39

9.39E-03 6.95E-01 6.35E-02

0.85 0.80

3.03E-02 2.28E-01

0.83 1.28

3.33E-03 1.77E-01

2.06 3.30

9.47E-03 3.85E-01


glutaredoxin 2 glutamyl-tRNA reductase porphobilinogen deaminase uroporphyrinogen-III synthase hypothetical protein delta-aminolevulinic acid dehydratase hypothetical protein hypothetical protein putative conserved transmembrane protein putative transmembrane protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error TetR-family protein transcriptional regulator hypothetical protein pyridoxamine 5'-phosphate oxidase family porin conserved hypothetical protein conserved hypothetical protein cytochrome P450 glutamate-1-semialdehyde-2,1-aminomutase phosphoglycerate mutase family protein conserved hypothetical protein cytochrome C biogenesis protein transmembrane region conserved membrane protein cytochrome c-type biogenesis protein CcsB conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein aminotransferase, class V superfamily protein keratin associated protein signal transduction histidine kinase two-component system regulator immunogenic protein two-component system response regulator trap transporter, 4tm/12tm fusion protein sugar transporter family protein

hemA hemC hemD hemB

hemL

ccsB

0.57 1.08 0.49 0.49 0.99 0.46 0.37 0.96 0.78 0.66

9.69E-05 1.18E-01 3.82E-04 2.06E-04 8.85E-01 3.51E-06 1.16E-06 6.84E-01 1.11E-02 7.66E-04

0.99 1.03 0.87 0.86 0.96 0.81 0.99 0.78 0.92 1.02

8.18E-01 6.16E-01 2.99E-02 5.07E-02 8.62E-01 5.50E-02 8.53E-01 4.71E-03 4.26E-01 3.83E-01

1.73 2.03 2.58 2.34 1.50 3.75 4.45 1.86 1.19 1.23

1.58E-02 1.14E-03 1.08E-02 2.96E-02 3.35E-01 1.67E-02 2.09E-02 7.24E-02 3.87E-01 4.69E-01

5.71 2.64 1.22 1.00 0.61 1.24 1.66 2.52 0.44 0.30 0.35

1.91E-03 8.34E-04 3.29E-01 9.85E-01 2.12E-04 1.98E-01 2.01E-02 8.70E-03 4.72E-05 1.28E-06 3.22E-06

0.33 0.48 1.40 1.06 1.14 0.80 0.63 0.97 0.84 0.85 1.11

1.08E-03 3.12E-03 1.73E-03 5.36E-01 1.91E-01 3.95E-02 5.18E-03 7.85E-01 1.66E-01 4.11E-02 5.23E-01

0.61 1.07 0.82 0.71 0.70 1.06 0.88 0.39 4.55 6.06 5.73

7.60E-02 7.90E-01 2.31E-01 1.07E-03 3.12E-02 5.12E-01 2.19E-01 3.36E-03 1.35E-02 2.06E-02 9.17E-03

0.41 0.60 0.41 1.04 3.43 1.07 0.42 0.81 1.91 1.80 2.14 1.32 1.66 0.32

5.75E-05 3.80E-04 1.55E-04 6.26E-01 2.85E-03 4.37E-01 4.35E-05 4.46E-02 1.91E-01 9.12E-02 3.52E-03 1.66E-02 3.53E-03 3.62E-05

0.99 1.05 0.85 0.92 0.74 0.90 0.92 0.79 1.59 0.94 1.23 0.84 1.14 1.02

9.33E-01 3.46E-01 5.06E-02 3.24E-01 1.87E-02 2.70E-01 2.35E-01 7.40E-03 2.78E-01 6.29E-01 1.49E-01 1.97E-01 3.74E-01 8.83E-01

8.66 4.03 2.03 1.45 1.26 1.65 2.46 1.54 2.08 1.15 0.45 0.57 0.65 1.87

3.74E-02 2.30E-02 4.30E-02 3.06E-03 4.57E-02 1.41E-02 1.15E-01 3.01E-01 3.96E-01 3.86E-01 8.53E-04 8.17E-03 8.59E-02 1.74E-01

MSMEG_0986 MSMEG_0987 MSMEG_0988 MSMEG_0989 MSMEG_0990 MSMEG_0991 MSMEG_0992 MSMEG_0993 MSMEG_0994 MSMEG_0995 MSMEG_0996 MSMEG_0997 MSMEG_0998 MSMEG_0999 MSMEG_1000 MSMEG_1001 MSMEG_1004

MSMEG_1060 MSMEG_1061 MSMEG_1062 MSMEG_1063 MSMEG_1064 MSMEG_1065 MSMEG_1066 MSMEG_1067 MSMEG_1068 MSMEG_1069 MSMEG_1070 MSMEG_1071 MSMEG_1072 MSMEG_1073 MSMEG_1074 MSMEG_1075

RemM protein hypothetical protein 1,4-dihydroxy-2-naphthoate octaprenyltransferase conserved hypothetical protein methylthioadenosine phosphorylase NAD-dependent epimerase/dehydratase 2-nitropropane dioxygenase, NPD histidine kinase DNA-binding response regulator ResD glycosyl transferase, family protein 2 conserved hypothetical protein conserved hypothetical protein oxidoreductase, molybdopterin binding integral membrane protein hypothetical protein acetyltransferase, gnat family protein, putative This is the transposed copy of the gene fragment that was disrupted by an IS1096 element elsewhere in the chromosome.; conserved hypothetical protein, interruption-N; identified by similarity to OMNI:NTL02MT01721 putative Lsr2 protein phosphohydrolase O-succinylbenzoic acid--CoA ligase conserved hypothetical protein phosphate/sulphate permease conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein regulatory protein amino acid permease-associated region 3-oxoacyl-[acyl-carrier-protein] reductase 3-oxoacyl-[acyl-carrier-protein] reductase agmatinase oxidoreductase, short-chain dehydrogenase/reductase family protein polysaccharide deacetylase naphthoate synthase

0.76 2.79 0.95 1.19 1.13 1.01 1.40 1.40 1.23 3.95 3.58 1.88 1.38 0.92 1.70 0.76

3.49E-04 1.98E-03 8.01E-01 2.18E-01 3.27E-01 6.97E-01 9.50E-02 9.63E-04 2.78E-02 2.89E-04 1.75E-02 2.20E-02 1.95E-01 4.65E-01 2.04E-02 3.54E-02

0.93 0.71 0.77 0.78 0.94 1.28 0.96 1.07 0.79 0.65 0.87 1.59 0.96 0.80 0.98 1.29


0.54 0.66 1.13 1.10 1.52 1.31 1.22 0.74 0.96 1.04 1.44 1.26 1.07 0.84 1.00 1.33


speB

0.99 1.72 1.21 0.93 1.06 1.17 0.76 1.05 1.65 1.09 1.18 1.73 1.47 1.14

9.66E-01 6.51E-04 1.19E-01 1.88E-01 5.55E-01 1.34E-01 6.68E-03 7.49E-01 4.73E-04 4.33E-01 2.38E-01 2.77E-02 1.38E-02 3.37E-01

1.06 0.71 0.89 0.88 0.88 0.71 0.86 0.86 0.84 0.89 0.88 1.02 1.02 1.02

7.10E-01 1.09E-02 1.14E-01 3.27E-01 3.18E-01 1.48E-02 2.01E-02 4.52E-02 1.93E-02 1.17E-01 6.66E-02 8.27E-01 7.92E-01 7.86E-01

0.88 0.84 0.47 2.05 1.96 2.53 3.04 3.33 1.08 1.83 1.22 1.11 0.96 1.02

7.26E-01 1.18E-01 2.48E-05 2.46E-02 1.68E-02 9.40E-03 4.83E-03 1.99E-03 2.95E-01 6.30E-02 4.36E-01 3.20E-01 4.20E-01 8.71E-01

menB

0.54 0.92 0.76

1.09E-03 2.09E-01 1.38E-01

0.96 1.00 0.96

4.62E-01 9.62E-01 6.41E-01

0.97 1.10 1.33

8.75E-01 7.48E-01 5.19E-02

menA mtaP

resD

MSMEG_1076 MSMEG_1077 MSMEG_1078 MSMEG_1079 MSMEG_1080 MSMEG_1081 MSMEG_1082 MSMEG_1083 MSMEG_1084 MSMEG_1085 MSMEG_1086 MSMEG_1087

MSMEG_1087

MSMEG_1088 MSMEG_1089 MSMEG_1090 MSMEG_1091 MSMEG_1092 MSMEG_1093 MSMEG_1094 MSMEG_1095 MSMEG_1096 MSMEG_1097 MSMEG_1098 MSMEG_1099 MSMEG_1100 MSMEG_1101 MSMEG_1102

conserved hypothetical protein conserved hypothetical protein hydrolase hypothetical protein large subunit of N,N-dimethylformamidase hypothetical protein putative response regulator hypothetical protein peptide/opine/nickel uptake family protein ABC transporter, periplasmic substrate-binding protein, putative dipeptide transport system permease protein DppB ABC transporter permease protein oligopeptide ABC transporter ATP-binding protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00005 oligopeptide ABC transporter ATP-binding protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00005 glutamyl-tRNA(Gln)/aspartyl-tRNA(Asn) gatA amidotransferase, A subunit hypothetical protein amidase urease accessory protein UreE 1 urease accessory protein UreF urease gamma/beta subunit ureC urease, alpha subunit ureG urease accessory protein UreG urease accessory protein UreD, putative glycosyl transferase, group 2 family protein acyl-CoA synthase hypothetical protein dgpf protein hypothetical protein twin-arginine translocation pathway signal

1.24 1.40 1.14 0.97 0.96 1.13 0.17 0.84

6.61E-01 1.66E-03 5.64E-01 7.90E-01 6.06E-01 1.77E-01 7.44E-05 1.85E-01

3.17 0.82 1.03 1.49 1.05 1.01 0.91 1.11

4.86E-02 1.59E-01 8.96E-01 2.24E-01 8.04E-01 9.37E-01 6.72E-01 3.93E-01

0.48 1.33 1.17 1.67 1.23 0.88 1.11 0.91

1.67E-02 4.65E-02 4.00E-01 3.90E-01 3.49E-01 5.33E-01 5.30E-01 5.18E-01

0.98

9.02E-01

1.10

3.86E-01

1.45

3.74E-01

1.10 1.01

5.27E-01 9.71E-01

1.06 1.00

5.97E-01 9.95E-01

0.93 0.82

6.55E-01 9.11E-02

1.41

3.88E-01

0.81

2.92E-01

1.04

2.35E-01

0.94

8.16E-01

1.16

4.14E-01

2.33

4.04E-01

1.72 1.57 1.46 1.17 1.08 1.37 1.34 1.10 1.01 1.09 1.74 1.15 2.25 2.26 0.94


1.08 0.99 0.74 1.11 1.08 0.88 0.96 0.99 1.47 2.22 0.95 0.99 0.87 0.62 1.17


0.79 0.61 0.38 0.99 0.99 1.01 1.09 1.06 1.06 0.33 0.75 0.96 0.93 1.05 0.86


MSMEG_1103 O-succinylbenzoate synthase MSMEG_1104 hypothetical protein MSMEG_1105 phthiodiolone ketoreductase; this gene contains a frame shift which is not the result of sequencing error MSMEG_1105 phthiodiolone ketoreductase; this gene contains a frame shift which is not the result of sequencing error MSMEG_1106 transcriptional regulator, AraC family protein MSMEG_1107 isonitrile hydratase, putative MSMEG_1108 hydrolase, alpha/beta fold family protein MSMEG_1109 2-oxoglutarate decarboxylase MSMEG_1110 probable conserved transmembrane protein MSMEG_1111 conserved hypothetical protein MSMEG_1112 aconitate hydratase, putative MSMEG_1113 glycosyl transferase MSMEG_1114 short chain dehydrogenase MSMEG_1115 menaquinone biosynthesis methyltransferase UbiE MSMEG_1116 gamma-glutamylisopropylamide synthetase MSMEG_1117 transcriptional regulator MSMEG_1118 amino acid permease MSMEG_1119 glutamine amidotransferase, class I MSMEG_1120 nitrilase/cyanide hydratase and apolipoprotein Nacyltransferase MSMEG_1121 conserved hypothetical protein MSMEG_1122 hypothetical protein MSMEG_1123 cobalamin synthesis protein MSMEG_1124 putative ferredoxin FdxA MSMEG_1125 regulatory protein, ArsR MSMEG_1126 hypothetical protein MSMEG_1127 probable conserved transmembrane protein MSMEG_1128 conserved hypothetical protein MSMEG_1129 D-amino-acid dehydrogenase MSMEG_1130 hypothetical protein MSMEG_1131 tryptophan-rich sensory protein MSMEG_1132 FAD binding domain, putative

0.90 9.11

1.74E-01 1.04E-01

0.90 0.47

4.65E-01 2.57E-02

1.46 1.21

1.34E-01 5.90E-01

9.14

3.82E-02

0.56

2.97E-02

1.60

1.35E-01

1.02 2.20 1.55 0.57 0.81 0.43 0.97 1.58 1.23 3.94

8.53E-01 1.91E-02 1.37E-02 7.61E-05 4.68E-02 1.65E-04 6.23E-01 2.34E-01 1.62E-01 1.82E-03

1.00 1.29 1.20 0.91 0.79 1.15 0.91 2.40 1.03 0.70

9.71E-01 4.13E-01 6.24E-01 2.79E-02 1.12E-02 1.62E-01 6.75E-01 2.14E-02 8.95E-01 6.55E-02

0.95 0.91 1.02 0.87 1.53 1.07 1.15 0.55 0.98 0.84

8.84E-01 5.30E-01 9.26E-01 4.49E-01 2.49E-04 5.12E-01 5.39E-01 5.88E-02 7.31E-01 4.09E-01

0.54 1.34 1.31 0.60 1.16

6.28E-04 4.80E-02 1.16E-02 1.15E-02 5.82E-01

1.19 0.92 0.83 1.09 0.72

4.84E-01 1.86E-01 1.78E-02 3.55E-01 1.03E-01

1.19 0.90 0.87 1.10 1.51

1.37E-01 1.22E-01 9.27E-02 4.97E-01 3.59E-01

0.79 0.46 0.87 0.72 1.85 1.13 3.03 1.80 4.71 1.51 1.57 0.88 1.09

5.34E-03 1.47E-05 3.98E-02 2.01E-02 3.12E-02 7.94E-02 2.57E-01 1.23E-03 1.06E-03 1.62E-01 2.25E-01 7.30E-01 6.45E-01

1.95 1.22 0.81 1.23 0.88 1.32 0.88 1.10 0.69 1.00 0.96 1.24 0.91

2.58E-01 1.01E-01 7.44E-02 3.16E-01 1.90E-01 2.88E-01 1.81E-02 5.66E-01 2.56E-02 9.96E-01 3.50E-01 1.42E-01 2.76E-01

1.01 11.63 0.89 1.20 1.42 1.09 1.03 1.73 0.97 1.13 1.44 14.60 1.19

8.79E-01 3.74E-01 2.00E-01 5.10E-01 2.60E-01 3.99E-01 8.80E-01 4.00E-01 7.12E-01 4.84E-01 1.24E-01 3.56E-01 2.25E-01

MSMEG_1133 bifunctional short chain isoprenyl diphosphate synthase MSMEG_1134 putative protease HtpX MSMEG_1135 hypothetical protein MSMEG_1136 conserved hypothetical protein MSMEG_1137 amino acid permease-associated region MSMEG_1138 alcohol dehydrogenase 1 MSMEG_1139 transcription regulator MSMEG_1140 glycerol-3-phosphate dehydrogenase 2 [NAD(P)+] (NAD(P)H-dependent glycerol-3phosphate dehydrogenase 2) MSMEG_1141 ABC-transporter integral membrane protein MSMEG_1142 ABC-transporter integral membrane protein MSMEG_1143 mce related protein MSMEG_1144 virulence factor Mce family protein MSMEG_1145 virulence factor Mce family protein MSMEG_1146 virulence factor Mce family protein MSMEG_1147 mce related protein MSMEG_1148 mce related protein MSMEG_1149 conserved hypothetical protein MSMEG_1150 conserved hypothetical protein MSMEG_1151 DNA-binding protein MSMEG_1152 citrate-proton symporter MSMEG_1153 FAD dependent oxidoreductase MSMEG_1154 formyl-coenzyme A transferase MSMEG_1155 carnitinyl-CoA dehydratase MSMEG_1156 dihydrodipicolinate synthetase MSMEG_1157 short chain dehydrogenase MSMEG_1158 5-oxovalerate dehydrogenase MSMEG_1159 ABC transporter component A MSMEG_1160 ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component MSMEG_1161 taurine transport system permease protein TauC MSMEG_1162 nitrilotriacetate monooxygenase component A MSMEG_1163 hypothetical protein MSMEG_1164 putative transporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error

0.75 1.13 1.16 0.99 1.17 2.33 1.48

7.68E-04 1.38E-01 1.38E-01 9.03E-01 5.05E-01 1.18E-02 1.74E-01

0.67 1.50 1.44 1.05 0.94 0.86 0.91

8.50E-03 1.22E-01 3.14E-01 4.79E-01 4.84E-01 1.88E-01 1.45E-01

1.21 1.14 1.01 0.41 1.07 0.97 1.10

4.49E-01 2.13E-01 9.10E-01 4.81E-04 7.80E-01 6.38E-01 2.79E-01

2.19 1.39 1.05 1.22 1.09 0.95 1.24 0.98 1.06 1.12 1.10 0.53 1.10 0.63 0.57 0.46 0.43 0.63 1.43 0.99


1.08 0.89 1.12 0.97 0.91 1.01 1.10 0.92 1.04 0.92 0.88 1.09 0.73 1.31 1.03 1.86 1.01 1.38 0.97 1.35


0.40 0.84 0.85 0.68 0.64 0.78 0.88 0.61 0.84 0.71 0.89 1.09 0.63 0.97 1.08 1.00 0.89 1.03 1.38 0.96


1.14 1.48 1.43 1.42

3.49E-01 2.59E-01 3.46E-01 2.50E-01

1.04 0.99 1.36 1.28

5.13E-01 8.86E-01 8.89E-02 2.32E-01

2.18 0.98 1.03 1.00

1.97E-01 5.72E-01 5.15E-01 7.36E-01

1.91

1.14E-01

1.30

1.26E-02

1.08

7.71E-02

MSMEG_1164 putative transporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_1164 putative transporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_1165 conserved hypothetical protein MSMEG_1167 cytochrome P450 MSMEG_1168 putative transcriptional regulator MSMEG_1169 integral membrane transport protein MSMEG_1170 conserved domain protein MSMEG_1171 Low molecular weight phosphotyrosine protein phosphatase MSMEG_1172 arsenical-resistance protein MSMEG_1173 transcriptional regulator, ArsR family protein MSMEG_1174 cadmium inducible protein cadi MSMEG_1175 putative transcriptional regulatory protein MSMEG_1176 hypothetical protein MSMEG_1177 cytosine/purines/uracil/thiamine/allantoin permease family protein MSMEG_1178 transcriptional regulator MSMEG_1179 urocanate hydratase MSMEG_1180 N-carbamoyl-L-amino acid hydrolase MSMEG_1181 formiminoglutamate deiminase MSMEG_1182 imidazolonepropionase MSMEG_1183 histidine ammonia-lyase MSMEG_1184 serine esterase, cutinase family protein MSMEG_1185 transcriptional regulator, AsnC family protein MSMEG_1186 putative permease MSMEG_1187 N-acyl-D-aspartate deacylase MSMEG_1188 conserved hypothetical protein MSMEG_1189 conserved hypothetical protein MSMEG_1190 serine/threonine-protein kinase PknD MSMEG_1191 hypothetical protein MSMEG_1192 M23 peptidase domain protein MSMEG_1193 TROVE domain protein MSMEG_1194 hypothetical protein MSMEG_1195 conserved hypothetical protein

arsB

hutU hutF hutI hutH

0.89

2.25E-01

0.89

2.59E-01

1.77

1.69E-01

1.08 1.32 6.21 1.49 0.96 1.00

4.84E-01 1.98E-02 5.89E-04 3.75E-02 6.68E-01 9.80E-01

1.03 0.96 0.92 0.95 1.16 1.30

6.39E-01 6.42E-01 5.68E-01 4.45E-01 9.31E-02 1.89E-01

1.02 1.34 0.85 1.12 3.05 1.06

3.97E-01 6.09E-02 7.11E-01 3.72E-01 3.50E-02 2.43E-01

0.83 0.58 1.04 2.76 1.06 0.39

2.20E-01 8.68E-03 5.90E-01 2.17E-05 5.43E-01 1.10E-03

1.06 1.01 0.91 0.90 0.78 1.05

4.81E-01 8.26E-01 4.18E-02 3.61E-01 1.47E-02 5.27E-01

1.10 0.87 0.81 0.63 1.17 1.11

4.86E-01 1.02E-01 5.31E-02 1.68E-02 4.20E-01 3.26E-01

0.91 0.90 1.01 0.88 1.01 0.97 0.94 1.64 0.86 1.32 2.98 1.31 1.52 1.67 0.45 2.28 1.63 1.60 1.21


1.18 1.29 1.07 0.96 0.98 0.86 0.96 1.43 1.16 0.91 0.98 0.88 0.77 1.15 1.04 0.88 1.64 1.20 0.78


1.13 1.19 1.51 1.02 1.22 0.98 1.20 0.10 1.08 0.93 1.47 1.67 0.73 0.96 0.99 0.97 1.02 0.50 1.63



SNF2 domain protein transcriptional regulator, LuxR family protein hypothetical protein conserved hypothetical protein serine/threonine-protein kinase PknD hypothetical protein hypothetical protein methoxy mycolic acid synthase 1 3-oxoacyl-[acyl-carrier-protein] synthase 2 cyclopropane-fatty-acyl-phospholipid synthase 1 hypothetical protein glycosyltransferase, group I glycosyltransferase, group I glycosidase conserved hypothetical protein Fatty acid desaturase hypothetical protein cytochrome P450 monooxygenase oxidoreductase serine/threonine-protein kinase PknE, putative ABC-type transport system periplasmic substratebinding protein MSMEG_1217 ABC-type transport system ATP-binding protein I MSMEG_1218 ABC-type transport system ATP-binding protein II MSMEG_1219 ABC-type transport system permease protein II MSMEG_1220 ABC-type transport system permease protein I MSMEG_1221 rifampin ADP-ribosyl transferase MSMEG_1222 ISMsm6, transposase MSMEG_1223 hypothetical protein MSMEG_1224 rifampin ADP-ribosyl transferase MSMEG_1225 conserved hypothetical protein MSMEG_1226 sulfatase-modifying factor 1 MSMEG_1227 transcriptional regulator, GntR family protein MSMEG_1228 sulfatase MSMEG_1229 DNA gyrase, B subunit MSMEG_1230 hypothetical protein

gyrB

1.79 1.56 1.45 0.67 1.48 0.66 3.53 7.31 2.87 6.40 2.11 2.49 1.56 1.89 0.74 1.49 14.66 1.90 1.17 1.10


1.74 1.21 1.10 1.12 0.74 0.89 1.55 0.80 0.95 0.83 1.02 0.84 0.82 0.97 0.99 0.76 2.67 1.03 0.97 0.99


1.13 1.15 1.14 1.20 0.87 1.07 0.53 0.57 1.09 0.51 0.89 1.09 1.16 1.38 0.97 0.82 0.15 0.84 1.01 1.11


2.19

2.43E-02

1.31

1.01E-01

0.25

8.92E-06

1.31

3.63E-01

1.20

9.89E-02

0.82

4.53E-01

1.43 1.19 1.89 1.27 1.32 2.22 1.27 0.92 0.48 0.38 0.61 1.05 1.71

2.54E-02 3.14E-01 1.54E-02 2.67E-01 3.81E-01 9.07E-04 1.28E-01 7.53E-01 4.88E-04 5.40E-05 9.80E-03 5.74E-01 2.74E-01

1.33 1.11 1.09 1.19 1.12 0.72 1.01 0.79 1.06 1.06 1.08 1.09 1.37

7.45E-02 1.78E-01 1.74E-01 3.32E-01 3.22E-01 1.06E-02 5.53E-01 8.14E-02 6.15E-01 5.54E-01 6.85E-01 1.54E-02 1.19E-01

0.68 0.85 0.28 0.97 1.03 0.97 0.71 1.99 1.36 2.67 0.98 1.00 3.03

1.00E-01 2.10E-01 1.47E-05 3.21E-01 8.23E-01 6.85E-01 5.81E-02 1.50E-01 4.84E-01 3.93E-02 5.13E-01 9.65E-01 3.96E-01

MSMEG_1231 inner membrane protein YidH MSMEG_1232 ABC transporter substrate-binding protein MSMEG_1233 ABC transporter permease protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_1234 taurine import ATP-binding protein TauB MSMEG_1235 sulfate permease MSMEG_1236 Mpr protein MSMEG_1237 hypothetical protein MSMEG_1238 type III restriction enzyme, res subunit MSMEG_1240 conserved hypothetical protein MSMEG_1241 conserved hypothetical protein MSMEG_1242 cysteine desulfurase IscS MSMEG_1243 conserved hypothetical protein MSMEG_1244 conserved hypothetical protein MSMEG_1245 phosphoadenosine phosphosulfate reductase MSMEG_1246 conserved hypothetical protein MSMEG_1247 conserved hypothetical protein MSMEG_1248 hypothetical protein MSMEG_1249 ISMsm7, transposase orfB MSMEG_1250 ISMsm7, transposase orfA MSMEG_1251 conserved hypothetical protein MSMEG_1252 conserved hypothetical protein MSMEG_1253 conserved hypothetical protein MSMEG_1254 DEAD/DEAH box helicase MSMEG_1255 UvrD/Rep helicase MSMEG_1256 hypothetical protein MSMEG_1259 hypothetical protein MSMEG_1260 hypothetical protein MSMEG_1261 hypothetical protein MSMEG_1262 conserved hypothetical protein MSMEG_1263 conserved hypothetical protein MSMEG_1264 prophage Lp1 protein 5 MSMEG_1265 conserved hypothetical protein MSMEG_1266 ankyrin-repeat containing protein

iscS

1.43 1.05

1.43E-01 8.87E-01

1.01 1.16

7.93E-01 2.98E-01

0.43 1.11

4.33E-03 4.54E-01

1.67 0.94 2.73 1.89 1.94 1.17 1.21 1.37 0.61 0.77 0.60 0.77 0.51 0.29 0.40 0.51 0.57 0.97 1.34 1.45 1.35 0.55 0.65 1.20 0.49 0.58 0.39 2.57 1.41 0.38 1.26

2.16E-01 4.52E-01 2.78E-01 2.21E-02 9.08E-02 2.55E-01 3.02E-02 4.01E-01 8.31E-03 2.16E-01 7.16E-03 2.28E-02 6.98E-04 6.70E-05 2.67E-04 2.64E-03 3.51E-03 8.13E-01 3.48E-02 2.09E-02 7.55E-03 1.07E-04 2.58E-03 5.42E-01 6.87E-05 4.06E-04 6.75E-04 8.13E-02 2.74E-01 9.29E-04 5.42E-01

0.96 0.97 0.94 0.94 0.87 0.83 0.95 1.06 1.05 1.04 1.07 1.20 1.49 1.45 1.35 1.20 1.20 1.04 0.95 1.13 1.11 1.21 1.03 0.62 1.05 1.10 1.55 0.73 0.78 1.13 1.06


1.07 0.89 3.73 1.06 1.55 0.50 1.29 1.14 1.29 1.32 1.40 0.81 0.90 0.89 0.96 0.98 1.11 1.03 0.60 0.32 0.26 0.47 0.98 1.62 0.66 0.62 1.72 1.03 0.96 0.61 1.13


MSMEG_1267 putative ribosylglycohydrolase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00782 MSMEG_1268 nudix hydrolase MSMEG_1269 Ser/Thr protein phosphatase family protein MSMEG_1270 hypothetical protein MSMEG_1271 hypothetical protein MSMEG_1272 putative ribosylglycohydrolase MSMEG_1273 conserved hypothetical protein MSMEG_1274 gluconolactonase MSMEG_1275 HNH nuclease, putative MSMEG_1276 hypothetical protein MSMEG_1277 hypothetical protein MSMEG_1278 death-on-curing protein MSMEG_1279 conserved hypothetical protein MSMEG_1280 hypothetical cytosolic protein MSMEG_1281 conserved hypothetical protein MSMEG_1282 hypothetical cytosolic protein MSMEG_1283 probable ribbon-helix-helix transcription factor, family protein MSMEG_1284 PIN domain protein MSMEG_1285 tetratricopeptide repeat family protein MSMEG_1286 sulfatase family protein MSMEG_1287 cyclase/dehydrase superfamily protein MSMEG_1288 conserved hypothetical protein MSMEG_1289 conserved hypothetical protein ilvD MSMEG_1290 dihydroxy-acid dehydratase MSMEG_1291 putative oxidoreductase MSMEG_1292 FAD binding domain in molybdopterin dehydrogenase protein MSMEG_1293 xanthine/uracil permeases family protein MSMEG_1294 allantoicase MSMEG_1295 transthyretin MSMEG_1296 uricase MSMEG_1297 hydroxydechloroatrazine ethylaminohydrolase MSMEG_1298 guanine deaminase

0.92 1.54 0.97 0.74 1.10 0.98 0.59 2.43 1.13 1.07 0.99 0.71 0.88 1.01 1.41 1.43


1.25 0.60 0.91 1.13 1.21 0.77 1.12 0.94 1.04 1.01 0.74 0.92 0.72 0.92 0.99 0.86


1.00 1.19 1.35 1.25 1.39 1.03 0.95 1.52 0.88 1.73 1.16 1.03 1.37 1.08 2.45 0.84


1.15 1.16 0.82 2.84 3.29 1.05 1.03 1.08 1.23

2.87E-01 1.40E-01 1.82E-02 2.12E-03 2.68E-04 8.40E-01 8.18E-01 4.53E-01 2.97E-02

0.84 0.90 0.95 0.83 0.81 1.34 0.97 1.06 0.80

3.38E-02 1.51E-01 3.87E-01 1.94E-02 4.04E-02 2.89E-01 8.13E-01 4.40E-01 7.64E-02

0.74 0.89 0.97 0.28 0.31 0.94 1.03 1.21 2.60

3.90E-03 1.84E-01 8.70E-01 9.37E-06 6.19E-05 3.65E-01 7.76E-01 4.19E-01 1.53E-02

1.07 0.45 0.48 0.52 0.67 0.66 0.86

3.74E-01 2.05E-03 1.51E-03 6.45E-04 1.97E-02 1.40E-02 4.46E-01

0.83 1.29 1.43 1.16 1.32 1.27 0.98

9.24E-02 4.05E-01 1.21E-01 2.90E-01 1.19E-01 3.62E-01 9.27E-01

1.71 0.65 0.90 0.73 0.79 1.01 1.00

6.02E-02 2.20E-02 2.74E-01 2.31E-01 3.44E-02 9.70E-01 7.30E-01

MSMEG_1299 oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_1300 hypothetical protein MSMEG_1301 NanT3 MSMEG_1302 alkylphosphonate uptake protein MSMEG_1303 putative transcriptional regulator MSMEG_1304 rhizopine catabolism protein MSMEG_1305 TetR family protein regulatory protein MSMEG_1306 aldehyde dehydrogenase (NAD) family protein MSMEG_1307 EthD protein MSMEG_1308 peptidase S15 MSMEG_1309 conserved hypothetical protein MSMEG_1311 oligopeptide transporter, OPT family protein MSMEG_1312 hypothetical protein MSMEG_1313 secreted protein MSMEG_1314 hypothetical protein MSMEG_1315 transporter, small conductance mechanosensitive ion channel (MscS) family protein MSMEG_1316 peptide chain release factor 3 MSMEG_1317 transcriptional regulator MSMEG_1318 polysaccharide deacetylase family protein MSMEG_1319 Asp/Glu racemase MSMEG_1320 major facilitator superfamily protein MFS_1 MSMEG_1321 5-carboxymethyl-2-hydroxymuconate deltaisomerase MSMEG_1322 ErfK/YbiS/YcfS/YnhG family protein MSMEG_1323 hypothetical protein MSMEG_1324 hypothetical protein MSMEG_1325 exodeoxyribonuclease V, alpha subunit MSMEG_1326 hypothetical protein MSMEG_1327 exodeoxyribonuclease V, beta subunit MSMEG_1328 exodeoxyribonuclease V, gamma subunit MSMEG_1329 major facilitator superfamily protein MFS_1, putative MSMEG_1330 MarR-family protein transcriptional regulator MSMEG_1331 enoyl-CoA hydratase MSMEG_1332 conserved hypothetical protein MSMEG_1333 conserved hypothetical protein

prfC

recD recB recC

1.05 3.75 1.59 0.92 2.24 1.17 1.03 1.69 2.44 2.74 1.19 2.06 2.25 0.72 1.42


0.82 1.05 1.21 0.91 1.79 1.15 0.97 0.94 0.87 0.96 0.91 0.96 0.85 1.34 0.91


0.84 0.56 0.91 0.93 1.00 1.13 1.01 0.72 0.95 1.18 1.08 0.67 0.96 1.11 1.88


0.82 0.64 1.03 0.58 0.70 0.36

3.74E-01 2.88E-04 8.18E-01 1.29E-02 3.37E-02 1.30E-03

1.80 0.75 0.76 0.86 1.05 1.29

1.03E-01 2.29E-03 8.39E-02 2.20E-01 5.49E-01 1.03E-01

0.75 2.12 1.37 0.98 1.39 1.10

5.85E-02 1.25E-01 6.04E-02 7.86E-01 3.61E-01 4.05E-01

1.31 0.53 0.86 1.14 0.83 1.46 1.06 0.81

1.15E-01 3.78E-03 3.35E-01 2.69E-01 1.07E-01 5.22E-02 7.26E-01 2.42E-01

1.31 0.80 0.95 1.35 1.52 0.82 0.96 1.00

3.86E-01 5.14E-02 5.20E-01 4.27E-01 3.27E-01 7.25E-02 5.67E-01 9.66E-01

1.82 1.63 1.14 1.16 1.22 1.03 1.62 1.86

1.75E-01 5.36E-03 4.46E-01 5.11E-01 1.48E-01 8.90E-01 1.51E-01 9.67E-02

0.88 0.83 0.74 1.37 3.19

1.15E-01 1.67E-02 1.87E-02 6.98E-03 5.21E-02

0.90 0.93 0.99 0.90 0.63

4.20E-01 3.63E-01 9.48E-01 6.64E-02 1.19E-01

1.50 1.10 1.32 0.59 1.14

2.43E-01 5.32E-01 8.60E-02 1.85E-02 6.98E-01

MSMEG_1334 metallo-beta-lactamase family protein MSMEG_1335 transcriptional regulator, BadM/Rrf2 family protein MSMEG_1336 flavohemoprotein, putative MSMEG_1339 ribosomal protein L33 MSMEG_1340 conserved hypothetical protein MSMEG_1341 MaoC family protein MSMEG_1342 conserved hypothetical protein MSMEG_1344 translocase MSMEG_1345 transcription antitermination protein NusG MSMEG_1346 ribosomal protein L11 MSMEG_1347 ribosomal protein L1 MSMEG_1348 RNA polymerase ECF-subfamily protein sigma factor MSMEG_1349 dgpf domain family protein MSMEG_1350 cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_1351 cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_1352 hydrolase, alpha/beta fold family protein MSMEG_1353 ABC1 family protein MSMEG_1354 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_1355 transcriptional regulator, TetR family protein MSMEG_1356 conserved hypothetical protein MSMEG_1357 conserved hypothetical protein MSMEG_1358 conserved hypothetical protein MSMEG_1359 DeoR-family protein transcriptional regulator MSMEG_1360 endonuclease/exonuclease/phosphatase MSMEG_1361 alpha-mannosidase MSMEG_1362 conserved hypothetical protein MSMEG_1363 glucokinase MSMEG_1364 50S ribosomal protein L10 MSMEG_1365 ribosomal protein L7/L12 MSMEG_1366 ABC transporter, ATP-binding protein MSMEG_1367 DNA-directed RNA polymerase, beta subunit MSMEG_1368 DNA-directed RNA polymerase, beta' subunit MSMEG_1369 LacI-family protein transcriptional regulator MSMEG_1370 2-deoxy-scyllo-inosamine dehydrogenase

rpmG

rplK rplA

rplL rpoB rpoC

0.48

2.11E-04

0.93

1.56E-01

1.01

7.41E-01

1.00 0.50 0.49 0.44 0.40 0.45 0.84 0.64 0.61 0.54

9.91E-01 3.58E-03 5.83E-04 5.42E-05 4.97E-05 3.66E-06 7.81E-02 1.44E-04 9.44E-05 4.71E-04

1.15 0.97 0.97 0.94 0.98 0.91 1.09 0.77 0.84 0.81

2.37E-01 7.87E-01 8.20E-01 5.82E-01 7.23E-01 3.42E-01 5.85E-01 3.49E-02 7.51E-02 5.01E-02

1.41 1.33 1.12 1.20 1.22 1.21 1.31 1.04 1.89 1.02

1.36E-01 3.03E-02 5.21E-01 3.69E-01 2.75E-01 1.88E-01 5.96E-02 5.35E-01 3.99E-02 7.58E-01

1.97 0.41 0.68 0.95 1.22 1.84

2.85E-01 2.32E-04 3.36E-04 5.11E-01 6.16E-03 4.78E-03

1.06 1.35 0.95 0.76 0.74 0.80

2.37E-01 2.75E-01 1.26E-01 4.44E-03 1.30E-02 1.64E-02

1.68 1.79 0.76 0.46 1.18 1.06

3.82E-01 3.89E-01 8.52E-02 6.46E-04 1.90E-01 5.92E-01

6.86 1.46 1.47 1.57 2.04 1.03 1.27 1.69 1.43 0.87 0.65 0.90 1.38 1.33 0.96 0.82 3.67


0.87 0.91 0.82 0.97 1.79 1.14 0.87 1.21 1.14 0.95 0.95 0.70 0.82 0.88 0.86 0.79 0.77


0.07 0.64 0.97 0.79 0.76 1.02 1.27 0.93 0.78 1.09 0.72 0.47 0.22 1.82 4.44 1.61 0.69


MSMEG_1371 conserved hypothetical protein MSMEG_1372 ABC transporter ATP-binding protein MSMEG_1373 ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components MSMEG_1374 ribose ABC transporter, periplasmic binding protein MSMEG_1375 tagatose-1,6-bisphosphate aldolase GatY MSMEG_1376 putative xylulose kinase MSMEG_1377 DeoR-family protein transcriptional regulator MSMEG_1378 1-phosphofructokinase MSMEG_1379 conserved hypothetical protein MSMEG_1380 transcriptional regulator MSMEG_1381 MmpS5 protein MSMEG_1382 MmpL5 protein MSMEG_1383 endonuclease IV MSMEG_1384 conserved hypothetical protein MSMEG_1385 PAP2 superfamily protein MSMEG_1386 hypothetical protein MSMEG_1387 putative acyl-CoA dehydrogenase MSMEG_1388 enoyl-CoA hydratase MSMEG_1389 conserved hypothetical protein MSMEG_1390 enoyl-CoA hydratase MSMEG_1391 transcriptional regulator, LysR family protein MSMEG_1392 alcohol dehydrogenase, class IV MSMEG_1393 conserved hypothetical protein MSMEG_1394 probable conserved transmembrane protein MSMEG_1395 lipoprotein, putative MSMEG_1396 LprB protein MSMEG_1397 transcriptional regulator, TetR family protein MSMEG_1398 ribosomal protein S12 MSMEG_1399 ribosomal protein S7 MSMEG_1400 elongation factor G; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00009; match to protein family HMM TIGR00231

rpsL rpsG

2.93 3.93

4.55E-03 1.31E-03

0.71 0.80

4.18E-02 1.79E-01

1.12 0.33

3.76E-02 1.17E-02

3.68

3.25E-04

0.92

3.62E-01

0.06

1.38E-07

3.36 1.22 1.18 1.20 1.16 1.38 1.08 0.51 0.68 0.88 1.12 0.97 8.23 1.78 1.98 1.44 2.15 0.60 1.06 0.68 0.58 1.01 0.60 0.58 0.51 0.34


0.82 0.89 0.94 0.85 0.86 1.22 0.96 0.88 0.94 0.98 0.83 0.74 0.41 0.98 1.12 0.83 0.94 1.06 1.64 0.96 1.09 0.96 1.00 1.13 1.04 0.89


0.14 1.04 1.00 1.16 1.68 0.69 1.01 1.05 6.72 0.95 3.75 1.13 0.92 1.11 1.57 2.56 1.45 1.97 1.50 0.82 0.72 0.84 1.48 1.26 1.04 1.09


0.36

5.32E-07

1.21

8.31E-02

0.79

4.49E-02

MSMEG_1400 elongation factor G; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00009; match to protein family HMM TIGR00231 tuf MSMEG_1401 translation elongation factor Tu MSMEG_1402 hypothetical protein MSMEG_1403 cutinase superfamily protein MSMEG_1406 conserved hypothetical protein MSMEG_1407 Na(+)/H(+) antiporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_1407 Na(+)/H(+) antiporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_1408 arginine/ornithine antiporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_1408 arginine/ornithine antiporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_1408 arginine/ornithine antiporter; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error arcA MSMEG_1409 arginine deiminase MSMEG_1410 carveol dehydrogenase MSMEG_1411 universal stress protein family protein MSMEG_1412 amino acid permease rocD MSMEG_1413 ornithine--oxo-acid transaminase MSMEG_1414 Amidinotransferase MSMEG_1415 AsnC-family protein transcriptional regulator MSMEG_1416 Pyridine nucleotide-disulphide oxidoreductase MSMEG_1417 glyoxalase family protein MSMEG_1418 RNA polymerase ECF-type sigma factor MSMEG_1419 conserved hypothetical protein MSMEG_1420 probable transcriptional regulatory protein MSMEG_1421 hypothetical protein MSMEG_1422 conserved hypothetical protein MSMEG_1423 radical SAM domain protein MSMEG_1424 FMN-dependent dehydrogenase

0.32 0.76 0.50 0.89 0.87

5.37E-06 3.50E-03 3.41E-04 1.75E-01 6.27E-01

0.92 0.95 0.80 0.71 0.92

2.98E-01 5.96E-01 5.85E-02 8.16E-02 7.05E-01

1.11 0.77 0.75 1.28 1.08

3.29E-01 3.19E-04 7.87E-02 1.17E-01 5.76E-01

1.54

4.29E-02

1.28

8.39E-02

1.13

1.12E-01

0.91

4.05E-01

1.05

3.64E-01

0.98

8.49E-01

1.14

2.33E-02

0.86

1.07E-01

1.26

1.66E-02

0.87

8.85E-02

2.04

2.80E-01

1.12

1.48E-01

1.01 1.21 1.52 2.19 1.79 2.09 1.70 0.82 0.46 1.36 1.20 0.99 0.82 1.19 1.12 1.03 1.23


1.09 1.46 0.86 1.25 1.09 1.33 1.31 1.32 1.09 1.25 1.33 1.10 0.90 1.26 1.33 1.62 1.23


0.92 1.10 0.41 0.93 0.74 0.64 0.69 0.91 0.87 0.65 0.69 0.86 1.10 0.42 0.32 0.57 0.42


MSMEG_1425 MSMEG_1426 MSMEG_1427 MSMEG_1428 MSMEG_1429 MSMEG_1430 MSMEG_1431 MSMEG_1432 MSMEG_1433 MSMEG_1434 MSMEG_1435 MSMEG_1436 MSMEG_1437 MSMEG_1438 MSMEG_1439 MSMEG_1440 MSMEG_1441 MSMEG_1442 MSMEG_1443 MSMEG_1444 MSMEG_1445 MSMEG_1446 MSMEG_1447 MSMEG_1448 MSMEG_1449

MSMEG_1450 MSMEG_1451 MSMEG_1452 MSMEG_1453 MSMEG_1454 MSMEG_1455 MSMEG_1456 MSMEG_1457 MSMEG_1458 MSMEG_1459

creatininase subfamily protein probable membrane sugar transferase transmembrane efflux protein glucose-methanol-choline oxidoreductase cytochrome P450-terp transcriptional regulator, TetR family protein cytochrome P450-terp acetylcholinesterase thioesterase conserved hypothetical protein ribosomal protein S10 ribosomal protein L3 ribosomal protein L4/L1 family protein ribosomal protein L23 ribosomal protein L2 ribosomal protein S19 50S ribosomal protein L22 ribosomal protein S3 ribosomal protein L16 ribosomal protein L29 30S ribosomal protein S17 NTP pyrophosphohydrolase transcriptional regulator, MerR family protein integral membrane transporter fasciclin domain protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02469 hypothetical protein arylsulfatase sulfatase-modifying factor 1 Citrate transporter hypothetical protein putative multidrug resistance protein hypothetical protein conserved hypothetical protein tena/thi-4 family protein Rieske [2Fe-2S] domain protein

rpsJ rplC rplD rplW rplB rpsS rpsC rplP rpmC

2.33 2.06 2.57 0.68 1.43 0.76 0.91 0.60 1.00 0.54 0.74 0.42 0.58 0.37 0.45 0.43 0.36 0.44 0.45 0.40 0.43 0.29 0.61 0.57

9.72E-03 1.30E-02 5.21E-02 5.15E-03 6.89E-02 7.80E-02 2.25E-01 3.84E-03 9.73E-01 3.64E-06 1.43E-04 6.05E-05 6.23E-05 4.06E-06 1.22E-04 8.24E-05 7.43E-05 2.26E-05 6.98E-05 5.45E-05 2.41E-04 3.41E-06 1.13E-02 3.15E-02

1.33 0.94 1.09 0.89 0.84 0.91 1.14 1.06 1.02 1.11 0.81 0.87 0.78 0.78 0.98 1.00 0.96 0.82 0.90 0.97 0.87 1.00 1.09 0.92


0.49 0.61 0.99 1.46 0.55 0.88 1.09 0.99 1.06 0.97 0.65 0.66 0.67 0.34 0.60 0.78 0.97 0.85 0.55 0.47 0.61 0.98 1.62 1.43


1.56 1.24 0.99 1.04 1.45 0.97 1.03 1.27 0.84 1.44 0.92

1.37E-01 8.14E-02 8.99E-01 8.15E-01 3.50E-03 7.08E-01 8.20E-01 2.00E-01 1.34E-01 2.65E-01 9.16E-03

0.96 1.18 1.40 1.09 0.92 1.14 1.73 1.01 1.22 0.92 0.87

6.53E-01 4.82E-01 1.48E-02 2.83E-01 5.26E-01 4.40E-01 4.40E-01 9.07E-01 1.70E-01 5.14E-01 2.40E-01

1.13 0.96 1.01 1.06 1.13 1.33 0.98 0.88 0.95 0.99 0.91

6.51E-01 6.06E-01 8.88E-01 6.81E-01 4.91E-01 3.99E-01 8.60E-01 4.28E-01 2.49E-01 4.55E-01 4.84E-01


Pyridine nucleotide-disulphide oxidoreductase 5-oxovalerate dehydrogenase ferredoxin gamma-glutamyltranspeptidase translation initiation inhibitor ribosomal protein L14 ribosomal protein L24 50S ribosomal protein L5 ribosomal protein S14p/S29e ribosomal protein S8 50S ribosomal protein L6 ribosomal protein L18 ribosomal protein S5 ribosomal protein L30 ribosomal protein L15 conserved hypothetical protein signal peptide peptidase SppA, 67K type major facilitator superfamily protein transporter, LysE family protein methyltransferase, putative, family protein methyltransferase methyltransferase methyltransferase preprotein translocase, SecY subunit adenylate kinase methionine aminopeptidase, type I RNA polymerase sigma-70 factor conserved hypothetical protein acetolactate synthase conserved hypothetical protein 3-oxoacyl-ACP synthase III histidinol-phosphate aminotransferase 2 transcriptional regulator, MarR family protein sensor histidine kinase sensor histidine kinase transcriptional regulatory protein DegU HAD-superfamily protein hydrolase subfamily protein IA, variant 3, putative

rplN rplX rpsN rpsH rplR rpsE rpmD rplO sppA

map

0.99 1.20 1.01 1.55 0.97 0.51 0.70 0.35 0.44 0.53 0.64 0.55 0.57 0.54 0.64 1.36 0.65 0.47 0.59 0.77 0.75 1.00 1.06 0.43 0.51 0.45 4.40 3.91 1.49 1.98 1.99 1.69 1.09 1.81 1.36 1.54

9.51E-01 5.72E-01 9.30E-01 3.36E-01 7.80E-01 1.04E-05 6.15E-03 1.65E-06 1.59E-05 5.82E-05 3.39E-04 4.08E-05 3.28E-05 7.73E-05 4.51E-04 1.51E-02 1.30E-04 2.09E-02 6.79E-03 6.66E-02 5.23E-02 9.82E-01 5.85E-01 1.95E-05 1.55E-05 4.69E-08 5.69E-05 9.01E-05 7.06E-02 7.13E-02 9.04E-02 1.65E-01 3.46E-01 2.89E-02 3.07E-02 6.81E-02

1.31 1.24 1.17 1.09 1.07 0.95 0.78 0.97 0.94 0.93 0.91 0.79 0.89 0.87 0.88 0.76 1.03 1.06 0.92 0.79 0.82 1.01 0.80 0.85 0.76 0.67 0.97 0.91 0.95 0.95 1.03 0.87 0.82 1.20 0.98 0.89


1.00 1.06 1.10 1.44 1.02 0.83 0.73 0.57 0.65 0.75 0.68 0.78 0.64 0.75 0.69 1.25 0.94 0.84 1.08 0.88 1.40 1.27 0.81 1.46 1.30 1.14 0.59 0.59 0.86 1.80 1.06 0.94 0.82 0.83 1.35 1.46


24.55

4.69E-03

0.91

5.38E-01

0.20

1.53E-04


3-hydroxyisobutyrate dehydrogenase acyl-CoA dehydrogenase family protein member methylmalonate-semialdehyde dehydrogenase oxygenase TetR family protein transcriptional regulatory protein methyltransferase, putative, family protein ABC transporter, ATP-binding protein probable antibiotic-transport integral membrane leucine and valine rich protein abc transporter probable antibiotic-transport integral membrane leucine and alanine and valine rich protein abc transporter integral membrane protein transcriptional regulator, TetR family protein D-aminopeptidase amino acid permease-associated region TetR-family protein transcriptional regulator dTDP-4-dehydrorhamnose 3,5-epimerase putative oxidoreductase dTDP-glucose 4,6-dehydratase conserved hypothetical protein conserved hypothetical protein two-component sensor histidine kinase thioredoxin reductase spfh domain/band 7 family protein, putative hypothetical protein translation initiation factor IF-1 ribosomal protein L36 ribosomal protein S13p/S18e ribosomal protein S11 ribosomal protein S4 DNA-directed RNA polymerase, alpha subunit 50S ribosomal protein L17 probable cutinase tRNA pseudouridine synthase A cutinase serine esterase, cutinase family protein

mmsB mmsA

rfbB

infA rpmJ rpsM rpsK rpsD rpoA truA

1.76 3.24 3.28 0.90

6.72E-04 5.17E-03 1.88E-04 3.90E-01

1.17 0.84 0.87 1.18

5.90E-02 2.42E-01 9.87E-02 5.24E-01

0.63 0.37 0.33 0.88

5.39E-02 5.84E-04 2.17E-04 2.96E-01

1.48 6.44 5.14

2.61E-01 8.27E-03 8.09E-03

0.87 1.42 1.22

1.76E-01 2.60E-01 4.72E-01

1.11 0.86 1.03

2.13E-01 4.69E-01 8.38E-01

3.80

9.21E-03

1.11

6.61E-01

1.23

4.67E-01

4.00 0.99 1.02 0.89 1.20 1.08 0.61 0.96 0.84 1.24 1.36 1.63 1.28 1.03 0.86 0.70 0.50 0.84 0.94 0.84 0.56 0.33 1.52 0.89 1.13 0.86


1.08 1.47 1.19 0.99 0.95 2.56 1.35 1.28 1.39 1.00 1.25 1.63 1.26 1.13 0.91 0.96 1.02 0.85 0.78 0.78 0.94 1.16 1.04 1.02 0.86 0.84


1.08 1.00 1.24 1.04 1.08 1.26 0.87 1.45 0.67 1.27 1.35 1.37 1.99 0.39 0.49 2.21 2.07 0.73 1.31 0.78 1.81 1.47 1.06 1.43 1.06 0.94


MSMEG_1530 MSMEG_1531 MSMEG_1532 MSMEG_1533 MSMEG_1534 MSMEG_1535 MSMEG_1536 MSMEG_1537 MSMEG_1538 MSMEG_1539 MSMEG_1540 MSMEG_1541 MSMEG_1542 MSMEG_1543 MSMEG_1544 MSMEG_1545 MSMEG_1546 MSMEG_1547 MSMEG_1548 MSMEG_1549 MSMEG_1550 MSMEG_1551 MSMEG_1552 MSMEG_1553 MSMEG_1554 MSMEG_1555

MSMEG_1556 MSMEG_1557 MSMEG_1558 MSMEG_1559 MSMEG_1560

integral membrane protein conserved hypothetical protein antibiotic biosynthesis monooxygenase subtilase family protein probable conserved membrane protein conserved hypothetical protein ftsk/spoiiie family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein ATP-dependent RNA helicase hypothetical protein transcriptional regulator eptc-inducible aldehyde dehydrogenase PduO protein conserved hypothetical protein coenzyme B12-dependent glycerol dehydrogenase small subunit glycerol dehydratase large subunit propanediol utilization: dehydratase, medium subunit glycerol dehydratase reactivation factor large subunit; this gene contains a frame shift which is not the result of sequencing error PduH protein hypothetical protein ethanolamine permease ethanolamine ammonia-lyase, large subunit ethanolamine ammonia-lyase, light chain conserved hypothetical protein, authentic frameshift; this gene contains a frame shift which is not the result of sequencing error; identified by similarity to RF:NP_854757.1 ribosomal protein L13 ribosomal protein S9 conserved hypothetical protein phosphoglucosamine mutase conserved hypothetical protein

eat eutB eutC

rplM rpsI glmM

0.73 0.66 1.05 2.56 1.07 1.26 1.24 1.39 1.65 2.12 0.55 1.45 2.25 2.43 1.56 1.21


1.42 1.02 0.89 1.05 1.57 1.16 0.89 1.03 1.04 1.05 1.15 1.17 0.74 0.84 0.82 0.91


2.61 1.45 1.61 0.87 0.88 1.05 1.05 0.77 0.87 0.66 1.74 1.18 0.97 0.10 0.71 1.34


3.09 2.74

2.60E-03 2.11E-03

0.76 0.68

1.72E-02 1.82E-02

0.21 0.25

8.04E-05 3.12E-05

2.11

1.27E-03

0.73

1.34E-02

0.28

8.01E-05

1.14 0.70 1.42 1.98 2.09 1.99

3.72E-01 1.64E-02 4.27E-01 4.98E-04 1.67E-04 4.25E-03

0.86 1.00 0.60 0.80 0.97 1.04

6.51E-02 9.69E-01 1.84E-02 3.11E-02 7.92E-01 7.99E-01

0.86 0.91 1.23 0.71 1.45 1.50

3.82E-01 1.36E-01 1.76E-01 1.74E-01 1.98E-01 1.42E-01

1.10 0.52 0.82 1.99 1.20 0.97

3.61E-01 1.44E-04 4.59E-03 1.09E-02 5.77E-03 8.57E-01

1.13 1.06 0.96 0.98 0.77 0.98

2.25E-01 5.95E-01 6.99E-01 9.18E-01 3.42E-02 8.66E-01

0.99 0.88 0.67 0.49 1.11 0.97

9.44E-01 1.10E-01 1.59E-02 1.56E-02 5.23E-02 6.20E-01

MSMEG_1561 LysR-family protein trancsriptional regulator MSMEG_1562 conserved hypothetical alanine and proline rich protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_1562 conserved hypothetical alanine and proline rich protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_1563 short-chain dehydrogenase/reductase SDR MSMEG_1564 lignostilbene-alpha,beta-dioxygenase MSMEG_1565 transcriptional regulator, TetR family protein MSMEG_1566 oxidoreductase MSMEG_1567 conserved hypothetical protein MSMEG_1568 glucosamine--fructose-6-phosphate aminotransferase, isomerizing MSMEG_1569 hypothetical protein MSMEG_1570 carboxylesterase MSMEG_1571 integral membrane protein MSMEG_1572 transcriptional regulator, GntR family protein MSMEG_1573 carbohydrate kinase family protein MSMEG_1574 glutamate decarboxylase MSMEG_1575 alanine racemase MSMEG_1576 alpha/beta hydrolase fold MSMEG_1577 conserved hypothetical protein MSMEG_1578 peptidase M22, glycoprotease MSMEG_1579 ribosomal-protein-alanine acetyltransferase MSMEG_1580 O-sialoglycoprotein endopeptidase MSMEG_1581 conserved hypothetical protein MSMEG_1582 chaperonin GroS MSMEG_1583 chaperonin GroL MSMEG_1584 hypothetical protein MSMEG_1585 cupin domain protein MSMEG_1586 beta-lactamase MSMEG_1587 alpha/beta hydrolase fold MSMEG_1588 conserved hypothetical protein MSMEG_1589 hypothetical protein MSMEG_1590 hypothetical protein MSMEG_1591 TnpC protein MSMEG_1591 TnpC protein

glmS

alr

rimI groS groL

2.01

1.54E-02

0.81

7.91E-02

1.24

2.57E-01

1.46

1.86E-01

0.87

1.24E-01

0.83

3.79E-02

0.86 2.08 1.53 1.04 1.81 0.53

2.84E-01 5.02E-02 3.45E-02 5.51E-01 3.72E-03 3.33E-04

1.12 0.86 1.66 1.03 1.08 0.95

4.74E-01 3.04E-01 1.52E-01 7.32E-01 3.74E-01 2.33E-01

1.20 1.24 0.92 0.90 2.33 1.05

3.45E-01 1.51E-01 2.42E-01 7.05E-01 9.49E-02 8.23E-01

0.66 0.62 1.34 1.23 1.09 1.27 0.84 0.65 0.67 0.52 0.72 0.70 0.63 0.44 0.95 0.77 0.49 1.81 1.89 1.14 2.32 0.94 1.08 1.94 1.45


0.84 1.22 0.76 1.11 1.13 0.77 0.78 1.02 0.94 0.93 0.96 1.10 0.96 1.57 0.60 0.74 0.93 1.08 1.60 1.54 1.47 2.42 0.97 0.76 0.83


1.76 0.91 1.42 1.01 0.98 2.58 0.96 3.55 3.88 2.96 3.21 2.21 2.70 1.89 0.45 0.49 0.79 0.85 0.98 1.31 0.68 1.31 1.08 1.59 1.26


MSMEG_1592 MSMEG_1593 MSMEG_1594 MSMEG_1595 MSMEG_1596 MSMEG_1597 MSMEG_1598 MSMEG_1599 MSMEG_1600 MSMEG_1601 MSMEG_1602 MSMEG_1603 MSMEG_1604 MSMEG_1605 MSMEG_1606 MSMEG_1607 MSMEG_1608 MSMEG_1609

MSMEG_1610 MSMEG_1611 MSMEG_1612 MSMEG_1613 MSMEG_1614 MSMEG_1615 MSMEG_1616 MSMEG_1617 MSMEG_1618

hypothetical protein hypothetical protein enoyl-CoA hydratase putative oxidoreductase transcriptional regulator Transcription factor WhiB conserved hypothetical protein RNA polymerase sigma-70 factor conserved hypothetical protein conserved hypothetical protein inosine-5'-monophosphate dehydrogenase IMP dehydrogenase family protein FAD dependent oxidoreductase phosphate transport system regulatory protein PhoU benzoylformate decarboxylase putative tautomerase glycosyl transferase beta-phosphoglucomutase hydrolase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR02009 glutamine-hydrolyzing GMP synthase transcriptional regulator, TetR family protein, putative extracellular solute-binding protein, family protein 3 ABC polar amino acid transporter, inner membrane subunit glutamine transport ATP-binding protein GlnQ gamma-glutamyltranspeptidase hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative kumamolisin hypothetical protein

guaB

phoU

ggt

1.71 1.98 2.05 1.32 0.95 0.59 0.42 1.63 1.03 1.72 1.33 0.83 1.00

6.49E-03 3.92E-01 1.89E-04 3.31E-01 5.66E-01 5.53E-02 5.63E-03 1.14E-03 6.31E-01 6.27E-03 5.99E-04 1.09E-01 9.87E-01

1.15 1.99 0.96 2.83 0.92 1.22 1.09 0.80 0.78 1.18 0.89 0.73 1.36

2.39E-01 1.06E-01 5.29E-01 6.10E-02 5.52E-01 4.03E-01 5.40E-01 4.89E-02 3.21E-02 2.04E-01 1.74E-01 9.98E-03 4.25E-02

0.53 0.90 0.88 1.00 0.90 1.89 1.20 2.42 1.69 1.32 1.24 1.47 2.12

1.00E-03 2.98E-01 3.56E-01 8.61E-01 2.31E-01 4.15E-01 2.34E-01 1.58E-02 1.05E-01 8.46E-03 5.90E-02 7.92E-03 1.20E-02

1.40 1.78 0.58 1.03

3.98E-01 3.68E-01 1.28E-02 7.99E-01

2.14 4.84 1.01 1.70

2.59E-03 3.82E-01 6.05E-01 3.88E-02

0.67 1.38 1.15 1.05

1.35E-01 1.14E-01 2.12E-01 4.78E-01

1.44 0.64

2.86E-02 4.17E-05

1.61 0.73

8.88E-02 2.49E-02

0.86 2.09

2.95E-01 6.39E-03

0.33

3.87E-04

1.02

6.55E-01

2.60

5.86E-02

0.72

8.63E-02

1.30

3.25E-01

1.06

7.12E-01

1.22 0.98 1.92

4.35E-01 7.75E-01 3.60E-01

0.81 0.85 1.15

4.15E-02 3.51E-01 6.51E-01

0.97 1.15 1.25

5.14E-01 3.17E-01 3.89E-01

1.06 1.20 0.93

5.81E-01 1.98E-01 3.82E-01

2.13 1.04 0.95

1.75E-01 7.89E-01 5.53E-01

0.86 0.21 0.28

1.80E-01 4.36E-07 2.17E-05

MSMEG_1619 hypothetical protein MSMEG_1620 conserved hypothetical protein MSMEG_1621 pyrimidine-specific ribonucleoside hydrolase RihA MSMEG_1622 putative DNA repair polymerase MSMEG_1623 short chain dehydrogenase MSMEG_1624 universal stress protein family protein MSMEG_1625 amino acid transporter, putative MSMEG_1626 putative DNA-binding protein MSMEG_1627 hypothetical protein MSMEG_1628 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_1629 hypothetical protein MSMEG_1630 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase MSMEG_1631 DNA-binding protein MSMEG_1632 hypothetical protein MSMEG_1633 DNA polymerase III, alpha subunit, putative MSMEG_1634 probable forkhead-associated protein MSMEG_1635 nitroreductase family protein MSMEG_1636 RNA methyltransferase, TrmH family protein, group 2 MSMEG_1637 periplasmic sensor signal transduction histidine kinase MSMEG_1638 Roadblock/LC7 domain protein MSMEG_1639 conserved hypothetical protein MSMEG_1640 ATP/GTP-binding protein MSMEG_1641 conserved hypothetical protein MSMEG_1642 ABC transporter, ATP-binding protein MSMEG_1643 hypothetical protein MSMEG_1644 hypothetical protein MSMEG_1645 NADH:flavin oxidoreductase/nadh oxidase MSMEG_1646 ribosomal RNA adenine dimethylase family protein MSMEG_1647 tetrahydrofolate dehydrogenase/cyclohydrolase FolD MSMEG_1648 putative transcriptional regulator MSMEG_1649 FAD dependent oxidoreductase

2.18 1.90

3.87E-01 1.65E-01

2.66 2.63

7.18E-02 1.34E-01

1.07 1.40

5.37E-01 2.40E-01

0.93 1.95 2.09 3.56 3.21 2.26 0.93

2.38E-01 1.42E-01 3.12E-03 3.53E-02 6.93E-02 4.29E-02 4.45E-01

0.93 1.67 0.90 1.50 1.34 0.98 0.80

1.34E-01 1.56E-01 2.98E-01 2.46E-02 1.47E-01 8.22E-01 3.31E-02

1.44 2.25 1.03 0.40 0.73 0.82 1.61

6.55E-02 2.69E-01 8.04E-01 1.58E-02 1.19E-01 3.07E-01 2.03E-01

1.07 0.83

7.48E-01 3.16E-03

1.28 0.76

2.46E-01 1.10E-01

1.01 0.43

9.78E-01 5.21E-03

1.39 1.44 0.65 0.95 0.34 0.55

3.28E-01 2.21E-03 7.16E-03 6.90E-01 8.61E-06 6.82E-06

1.14 1.04 0.89 1.77 0.88 0.97

4.98E-01 7.86E-01 3.21E-01 3.18E-01 3.83E-01 3.11E-01

1.05 1.16 1.04 1.15 0.74 0.77

5.52E-01 7.30E-02 1.48E-01 3.72E-01 3.10E-01 1.85E-01

0.58

2.17E-03

0.98

7.02E-01

1.27

2.11E-01

2.70 1.90 1.17 1.08 0.30 0.58 0.37 0.75 0.80

1.31E-05 6.95E-04 1.36E-01 2.38E-01 4.06E-07 2.31E-05 6.11E-05 7.61E-03 8.40E-02

0.79 0.67 0.82 0.71 0.84 1.08 0.90 0.99 0.72

3.53E-02 2.21E-02 1.11E-01 1.40E-02 2.02E-01 2.98E-01 2.00E-01 8.85E-01 3.51E-02

0.36 0.49 0.56 0.70 1.08 1.73 1.62 0.90 1.04

7.37E-04 6.96E-04 3.82E-03 1.61E-02 6.50E-01 1.55E-01 1.72E-01 3.35E-01 6.23E-01

1.02

9.13E-01

1.24

1.15E-01

0.99

9.04E-01

0.86 1.31 1.06

4.24E-02 3.31E-01 6.02E-01

0.85 1.82 1.14

8.35E-02 9.30E-02 3.60E-01

1.13 0.90 0.87

2.44E-01 3.09E-01 3.48E-01


methyltransferase type 11 homoserine O-acetyltransferase O-acetylhomoserine sulfhydrylase hypothetical protein isocitrate dehydrogenase, NADP-dependent hydrolase, alpha/beta fold family protein, putative exodeoxyribonuclease III tryptophanyl-tRNA synthetase ribonuclease, putative multidrug resistance protein, SMR family protein oxidoreductase, 2-nitropropane dioxygenase family protein D-alanyl-D-alanine carboxypeptidase taurine-pyruvate aminotransferase transcriptional regulator, AsnC family protein hypothetical protein aldehyde dehydrogenase (NAD) family protein RNA polymerase sigma-70 factor IS110 family transposase, truncation; identified by similarity to OMNI:MT3430 pyridoxamine 5'-phosphate oxidase family succinate dehydrogenase, iron-sulfur protein succinate dehydrogenase, flavoprotein subunit succinate dehydrogenase hydrophobic membrane anchor protein SdhD succinate dehydrogenase, cytochrome b556 subunit cytidine deaminase hypothetical protein pyrimidine-nucleoside phosphorylase adenosine deaminase aspartate ammonia-lyase transcriptional regulator, LysR family protein AmiB conserved hypothetical protein endoribonuclease L-PSP superfamily protein flavin-containing monooxygenase FMO

metX

xth trpS

sdhB sdhA

sdhC cdd add aspA

0.73 0.97 0.76 0.98 0.39 2.78 0.45 0.51 0.55 0.67

7.95E-04 5.62E-01 1.20E-02 7.42E-01 1.08E-05 6.46E-04 3.49E-03 4.90E-04 4.08E-05 4.67E-03

0.87 0.80 0.70 1.17 1.05 0.82 1.07 0.87 1.18 0.95

4.81E-01 2.67E-01 7.80E-02 2.89E-01 6.76E-01 9.43E-02 6.48E-01 6.97E-02 3.57E-01 6.10E-01

0.87 0.76 0.69 1.19 1.58 0.77 1.65 1.60 0.98 1.38

3.58E-01 1.08E-01 1.94E-02 7.30E-02 5.96E-02 1.78E-01 2.60E-01 1.47E-01 8.68E-01 1.56E-02

0.56 1.28 1.18 1.46 1.58 0.99 2.00

7.31E-03 1.21E-01 1.13E-01 2.64E-02 1.46E-02 8.76E-01 7.04E-04

1.16 0.96 0.71 0.87 0.73 0.72 0.89

1.66E-01 7.91E-01 2.41E-02 2.22E-01 4.29E-02 8.14E-03 2.01E-01

3.98 1.36 0.44 0.34 0.80 0.75 1.62

3.20E-01 4.36E-01 1.95E-04 5.40E-05 1.92E-01 6.55E-02 1.21E-03

1.42 1.79 0.27 0.31

7.80E-02 3.94E-02 3.89E-07 1.06E-05

0.77 1.04 0.86 1.05

8.87E-03 6.79E-01 1.13E-01 5.74E-01

0.86 1.00 2.46 2.02

2.97E-01 9.89E-01 1.20E-01 2.10E-02

0.39

2.83E-06

0.92

1.41E-01

2.09

3.75E-02

0.39 0.63 1.10 0.85 1.14 2.32 1.13 2.50 1.49 2.31 2.43

1.55E-05 2.45E-03 5.40E-01 5.58E-03 4.32E-01 2.89E-03 2.35E-01 9.51E-04 1.06E-02 1.55E-03 4.68E-04

0.87 0.92 0.88 0.89 0.76 1.11 0.92 1.61 1.04 1.01 1.06

6.73E-02 6.17E-01 2.00E-01 3.73E-01 2.51E-01 5.13E-01 2.12E-01 9.49E-03 6.27E-01 9.57E-01 5.56E-01

1.79 1.70 1.62 2.48 0.96 0.12 1.20 0.16 0.14 0.41 0.16

6.51E-02 1.95E-01 2.68E-01 4.53E-03 4.45E-01 6.83E-06 1.74E-01 9.11E-05 1.95E-05 2.62E-02 4.13E-05

MSMEG_1683 cytosine/purine/uracil/thiamine/allantoin permease family protein MSMEG_1684 conserved hypothetical protein MSMEG_1685 hypothetical protein MSMEG_1686 NPL/P60-family protein secreted protein MSMEG_1687 hypothetical protein MSMEG_1688 cupin domain protein MSMEG_1689 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_1690 putative ECF sigma factor RpoE1 MSMEG_1691 transcriptional regulatory protein MSMEG_1692 ECF-family protein RNA polymerase sigma MSMEG_1693 succinate dehydrogenase [ubiquinone] flavoprotein subunit MSMEG_1694 uracil phosphoribosyltransferase MSMEG_1695 phosphoglucomutase/phosphomannomutase MSMEG_1696 regulatory protein, MarR MSMEG_1697 hypothetical protein MSMEG_1698 putative ammonia monooxygenase superfamily protein MSMEG_1699 pentachlorophenol 4-monooxygenase MSMEG_1700 TetR-family protein transcriptional regulator MSMEG_1701 purine nucleotide phosphorylase MSMEG_1702 amidohydrolase MSMEG_1703 amidohydrolase MSMEG_1704 ABC transporter MSMEG_1705 D-xylose transport ATP-binding protein XylG MSMEG_1706 xylose transport system permease protein XylH MSMEG_1707 phosphatase YfbT MSMEG_1708 ribose operon repressor, putative MSMEG_1709 inner membrane ABC transporter permease protein YjfF MSMEG_1710 ribose transport system permease protein RbsC MSMEG_1711 ATP binding protein of ABC transporter MSMEG_1712 ABC transporter periplasmic-binding protein YtfQ MSMEG_1713 L-ribulokinase MSMEG_1714 L-ribulose-5-phosphate 4-epimerase UlaF MSMEG_1715 L-arabinose isomerase

upp

araB araA

2.45 0.40 1.18 1.08 1.12 1.62 1.04 1.28 1.20 1.13

1.28E-04 5.92E-07 4.25E-01 3.37E-01 6.75E-02 4.24E-02 4.72E-01 5.51E-02 1.03E-01 3.19E-01

1.23 1.15 0.98 1.02 1.28 1.02 1.05 1.03 1.06 1.11

1.14E-01 4.32E-02 7.59E-01 7.74E-01 2.34E-01 8.01E-01 5.42E-01 4.45E-01 6.27E-01 4.99E-02

0.14 0.73 1.15 1.14 0.87 1.17 1.33 1.47 1.16 1.02

1.76E-08 6.65E-02 3.37E-01 5.06E-01 1.84E-01 5.10E-01 8.98E-02 3.84E-01 3.48E-01 8.73E-01

1.28 0.64 1.28 0.90 1.41

7.19E-02 5.73E-03 1.87E-01 5.08E-01 3.43E-01

1.32 1.05 1.10 1.90 1.42

1.36E-01 6.01E-01 3.14E-01 2.65E-01 1.23E-01

1.02 0.85 0.85 0.97 1.03

7.89E-01 1.26E-01 1.61E-01 4.75E-01 1.59E-01

0.69 1.43 0.84 0.67 1.67 1.10 1.07 1.11 0.74 0.60 0.68

3.97E-02 1.88E-01 1.44E-01 1.51E-02 1.95E-04 5.40E-01 8.22E-01 7.22E-01 2.93E-01 1.05E-02 4.99E-02

18.97 1.66 5.09 0.82 1.51 1.14 1.05 1.20 1.23 1.07 1.06

2.00E-01 1.70E-01 1.35E-01 4.10E-02 9.89E-02 5.31E-01 8.13E-01 4.75E-01 4.90E-01 6.63E-01 6.53E-01

1.85 1.06 1.02 0.94 2.34 2.13 0.27 0.15 0.53 0.94 1.17

4.15E-01 7.46E-01 9.06E-01 2.90E-01 9.87E-03 2.19E-02 2.74E-03 2.90E-06 8.00E-03 2.97E-01 3.40E-01

1.03 0.62 0.80

8.59E-01 9.26E-03 1.62E-01

0.97 1.17 0.92

7.87E-01 3.87E-01 4.61E-01

0.70 0.63 0.09

1.15E-01 5.16E-02 8.41E-06

0.99 0.40 0.54 0.40

9.47E-01 4.93E-03 2.97E-02 3.71E-03

0.86 1.03 1.16 0.97

3.75E-01 8.68E-01 3.79E-01 8.92E-01

0.12 0.86 0.56 1.04

2.86E-05 1.11E-01 2.02E-02 6.39E-01

MSMEG_1716 IS3 family protein element, transposase orfA MSMEG_1717 ISMsm8, transposase MSMEG_1718 This gene is disrupted by an IS element.; IS3 family element, transposase orfB, interruption-N; identified by similarity to GP:15619023 MSMEG_1719 This gene is disrupted by an IS element.; IS3 family element, transposase orfB, interruption-C; identified by similarity to GP:15619023 MSMEG_1721 IS1137, transposase orfB MSMEG_1722 hypothetical protein MSMEG_1723 hypothetical protein MSMEG_1724 conserved hypothetical protein MSMEG_1729 This gene is disrupted by an ISMsm1 element.; ISMsm5, transposase, interruption-N; identified by similarity to GB:CAD18826.1 MSMEG_1731 IS6120, transposase MSMEG_1731 IS6120, transposase MSMEG_1731 IS6120, transposase MSMEG_1732 Transposase IS116/IS110/IS902 family protein MSMEG_1733 conserved hypothetical protein MSMEG_1734 conserved hypothetical protein MSMEG_1735 dihydrolipoamide dehydrogenase MSMEG_1736 glycerol-3-phosphate dehydrogenase 2 MSMEG_1737 RNA pseudouridine synthase family protein MSMEG_1738 probable conserved transmembrane protein MSMEG_1739 enoyl-CoA hydratase/isomerase family protein MSMEG_1740 dehydrogenase/reductase SDR family protein member 4 MSMEG_1741 TetR-family protein transcriptional regulator MSMEG_1742 oxidoreductase MSMEG_1743 Fatty acid desaturase MSMEG_1744 hypothetical protein MSMEG_1745 transcriptional regulator MSMEG_1746 6-hydroxy-D-nicotine oxidase MSMEG_1747 RNA polymerase sigma-70 factor MSMEG_1749 putative monooxygenase MSMEG_1750 hypothetical protein MSMEG_1750 hypothetical protein

0.22 0.77

2.47E-06 2.32E-01

1.47 1.05

7.11E-02 7.52E-01

1.04 0.94

5.13E-01 4.30E-01

0.71

3.10E-03

1.00

9.93E-01

0.88

3.74E-01

0.79 0.62 0.75 0.76 1.42

3.19E-01 2.20E-03 5.04E-02 2.69E-02 8.65E-03

1.62 2.07 1.38 1.09 1.23

1.66E-01 1.02E-01 6.75E-03 4.89E-01 1.45E-01

1.01 1.41 0.78 1.41 0.39

9.65E-01 2.88E-01 1.90E-01 3.49E-01 1.70E-04

0.95 0.88 1.26 0.76 1.18 1.00 0.53 0.51 1.16 0.43 3.16 0.47

1.15E-01 8.71E-03 3.27E-02 3.77E-02 5.21E-01 9.86E-01 5.36E-04 1.92E-04 1.01E-01 2.99E-04 1.73E-01 2.15E-06

0.92 0.77 0.88 1.11 1.50 1.13 1.11 0.97 0.97 1.05 0.52 1.16

2.79E-01 1.99E-02 1.03E-01 1.42E-01 3.43E-01 2.72E-01 9.54E-02 8.20E-01 5.83E-01 5.81E-01 1.33E-02 3.32E-01

0.48 1.52 13.61 1.01 1.01 1.17 0.72 0.87 1.11 1.24 28.81 1.41

2.21E-05 2.23E-01 3.47E-01 9.21E-01 9.39E-01 4.51E-01 5.87E-03 3.16E-01 5.50E-01 7.15E-02 1.10E-01 1.64E-01

0.71 0.51 0.53 0.45 0.73 0.81 0.98 1.01 4.18 0.82 1.15

4.63E-02 1.04E-04 1.86E-02 3.81E-03 4.28E-02 5.89E-02 8.95E-01 9.73E-01 6.31E-03 3.76E-02 4.39E-01

0.94 1.40 0.95 1.12 1.89 1.22 1.16 1.00 1.55 0.91 1.04

4.97E-01 1.54E-01 6.73E-01 1.72E-01 2.82E-01 1.96E-01 1.53E-01 9.79E-01 2.78E-01 2.63E-01 6.77E-01

0.92 1.05 1.28 0.98 1.40 1.07 3.79 0.98 0.68 1.14 1.08

8.06E-01 6.49E-01 3.70E-01 3.71E-01 3.65E-01 1.73E-01 3.64E-01 9.31E-01 1.26E-01 2.95E-01 5.46E-01


norsolorinic acid reductase hypothetical protein mtnN MTA/SAH nucleosidase conserved hypothetical protein anti-sigm factor, ChrR endonuclease VIII and dna n-glycosylase with an ap lyase activity DEAD/DEAH box helicase hypothetical protein hypothetical protein short-chain dehydrogenase/reductase SDR integral membrane protein piperideine-6-carboxylic acid dehydrogenase leucine-responsive regulatory protein L-lysine-epsilon aminotransferase restriction endonuclease family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein UsfY protein conserved hypothetical protein methylase, putative conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein cytochrome P450 monooxygenase ribonuclease Z UsfY protein conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein oxidoreductase, short chain dehydrogenase/reductase family protein hypothetical protein type I topoisomerase hypothetical protein stas domain, putative

1.05 1.12 0.47 0.67 2.91

7.01E-01 3.93E-01 5.43E-04 3.51E-03 1.11E-02

1.46 1.54 1.08 1.14 0.67

2.08E-01 1.58E-01 4.52E-01 2.88E-01 8.57E-03

1.16 1.08 1.31 1.15 0.89

2.34E-01 3.61E-01 7.43E-02 6.45E-01 9.87E-02

1.99 2.20 1.28 3.89 1.05 1.34 0.66 1.12 0.64 0.67 1.51 1.10 1.02 0.66 1.59 1.96 1.32 2.32 3.95 1.01 1.99 1.78 1.29 1.15 1.11 1.00


0.94 1.01 2.14 1.76 0.80 1.11 1.79 0.92 2.35 0.93 2.17 2.27 3.23 2.14 3.09 2.81 1.97 1.71 1.90 1.67 1.08 2.36 1.58 1.20 1.38 1.30


1.39 1.89 0.59 0.76 0.93 0.91 0.80 0.86 0.81 0.87 0.54 0.60 0.73 0.63 0.68 0.25 0.28 0.27 0.43 0.70 1.42 0.27 0.97 1.43 1.11 1.00


2.19 1.18 2.42 1.23 5.30

2.97E-01 6.80E-01 2.36E-01 1.99E-01 1.04E-03

2.38 2.62 1.72 1.44 1.44

4.87E-02 3.80E-02 1.86E-01 2.30E-01 1.05E-01

0.34 0.58 1.09 1.10 0.45

3.10E-03 2.21E-01 6.59E-01 3.12E-01 1.00E-03

MSMEG_1787 MSMEG_1788 MSMEG_1789 MSMEG_1790 MSMEG_1791 MSMEG_1792 MSMEG_1793 MSMEG_1794 MSMEG_1795 MSMEG_1796 MSMEG_1797 MSMEG_1798 MSMEG_1799 MSMEG_1800 MSMEG_1801 MSMEG_1802 MSMEG_1803 MSMEG_1804 MSMEG_1805 MSMEG_1806 MSMEG_1807 MSMEG_1808 MSMEG_1809 MSMEG_1810 MSMEG_1811 MSMEG_1812 MSMEG_1813 MSMEG_1814 MSMEG_1815 MSMEG_1816

MSMEG_1816

RsbW protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein UsfY protein conserved hypothetical protein membrane protein dehydrogenase 2-deoxy-scyllo-inosamine dehydrogenase membrane protein salicylate esterase major facilitator superfamily protein transcriptional regulator hypothetical protein hypothetical protein ChaB protein RsbW protein RNA polymerase sigma-F factor conserved hypothetical protein conserved hypothetical protein acetyl-/propionyl-coenzyme A carboxylase alpha chain Fe-S metabolism associated SufE putative thiosulfate sulfurtransferase hypothetical protein maf septum formation protein Maf conserved hypothetical protein propionyl-CoA carboxylase beta chain hypothetical protein hypothetical protein hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error; identified by Glimmer2; putative hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error; identified by Glimmer2; putative

1.17 3.02 3.14 3.37 5.88 1.39 1.01 1.37 1.39 1.39 1.59 1.16 1.01 1.04 1.20 1.61 1.20 0.56 0.24 1.05


1.36 3.54 2.74 2.95 1.14 1.40 0.95 1.48 0.91 0.71 0.98 0.90 0.75 1.07 1.41 2.04 1.23 1.11 0.68 1.08


0.70 0.25 0.20 0.15 0.60 0.92 0.88 0.73 1.26 1.54 1.11 0.93 0.82 1.01 1.03 0.39 0.51 0.77 3.56 1.56


0.45 0.64 0.94 2.56 0.14 0.30 0.36 1.03 0.96

4.27E-04 5.57E-04 1.40E-01 8.17E-03 5.88E-08 4.66E-06 2.22E-05 6.98E-01 7.75E-01

0.76 0.89 1.05 0.79 1.04 0.79 0.92 0.96 1.00

6.45E-02 1.57E-01 2.67E-01 2.68E-01 8.24E-01 1.44E-01 3.89E-01 7.38E-01 9.23E-01

2.00 1.58 1.48 0.17 4.21 3.03 2.48 1.40 1.04

9.12E-02 1.18E-03 4.49E-03 4.15E-06 6.25E-02 7.00E-02 2.51E-02 4.34E-01 5.10E-01

1.32

2.19E-01

0.84

3.01E-01

1.09

5.63E-02

0.95

6.78E-01

1.24

3.18E-01

0.94

4.66E-01

MSMEG_1817 probable conserved transmembrane protein MSMEG_1818 Bacterial membrane flanked domain protein MSMEG_1819 phosphoribosylaminoimidazole carboxylase, ATPase subunit MSMEG_1820 phosphoribosylaminoimidazole carboxylase, catalytic subunit MSMEG_1821 acyl-CoA dehydrogenase MSMEG_1822 biotin-[acetyl-CoA-carboxylase] ligase MSMEG_1823 conserved hypothetical protein MSMEG_1824 transcriptional regulator, LytR family protein MSMEG_1825 dTDP-4-dehydrorhamnose reductase MSMEG_1826 dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase MSMEG_1827 hydrolase, nudix family protein, putative MSMEG_1828 Nucleotidyl transferase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00132; match to protein family HMM PF00483 MSMEG_1829 F420-0:gamma-glutamyl ligase MSMEG_1830 lppg:fo 2-phospho-l-lactate transferase MSMEG_1831 Transcription factor WhiB MSMEG_1832 conserved hypothetical protein MSMEG_1833 conserved hypothetical protein MSMEG_1834 phosphomannomutase/phosphoglucomutase MSMEG_1835 TobH protein MSMEG_1836 mannose-6-phosphate isomerase, class I MSMEG_1837 secreted protein MSMEG_1838 cationic amino acid transporter MSMEG_1839 alkane 1-monooxygenase MSMEG_1840 rubredoxin MSMEG_1841 rubredoxin MSMEG_1842 transcriptional regulator, TetR family protein

0.56 0.61

1.48E-05 1.44E-02

1.11 1.16

1.55E-01 2.16E-02

1.19 1.04

3.19E-01 1.50E-01

purK

0.63

2.42E-04

0.87

1.89E-02

1.75

4.63E-02

purE

0.65 0.98 0.53 0.88 0.67 0.67

1.27E-03 9.14E-01 6.10E-04 1.56E-01 7.90E-03 2.47E-04

0.80 1.17 1.05 1.39 1.13 1.06

3.72E-02 3.32E-01 6.16E-01 8.55E-02 2.52E-01 1.16E-01

1.76 3.49 3.96 0.99 1.53 1.73

1.83E-02 9.25E-03 3.09E-02 9.21E-01 7.53E-02 9.23E-03

0.38 0.54

2.67E-05 1.74E-03

1.08 1.02

3.67E-01 8.48E-01

2.08 0.95

2.77E-02 4.38E-01

0.29 0.76 0.80 1.74 0.62 1.02 0.81 1.09 0.84 0.87 1.49 1.45 1.70 1.60 0.85


0.83 0.93 0.94 0.63 1.12 0.86 0.80 0.81 0.77 0.98 1.19 0.86 0.98 0.87 1.06


2.06 1.51 1.02 1.46 1.12 0.84 0.68 1.33 1.50 0.47 0.32 0.76 0.89 0.70 1.04


rfbD

cofD

manA

MSMEG_1843 adenosylhomocysteinase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00670; match to protein family HMM PF02254; match to protein family HMM PF02826; match to protein family HMM PF05221; match to protein family HMM TIGR00936 MSMEG_1843 adenosylhomocysteinase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00670; match to protein family HMM PF02254; match to protein family HMM PF02826; match to protein family HMM PF05221; match to protein family HMM TIGR00936 MSMEG_1844 conserved hypothetical protein MSMEG_1845 YghA protein MSMEG_1846 polysulphide reductase, NrfD MSMEG_1847 4Fe-4S ferredoxin, iron-sulfur binding protein MSMEG_1848 formate dehydrogenase-O, major subunit; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00384; match to protein family HMM PF04879 MSMEG_1848 formate dehydrogenase-O, major subunit; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00384; match to protein family HMM PF04879 MSMEG_1849 selenocysteine-specific translation elongation factor MSMEG_1850 L-seryl-tRNA selenium transferase MSMEG_1852 selenide, water dikinase

ahcY

0.55

7.94E-05

1.12

3.28E-01

1.29

3.32E-01

ahcY

0.48 1.16 0.79 1.18 1.05

9.07E-05 1.90E-01 3.60E-01 5.55E-01 5.99E-01

0.95 1.09 0.80 1.08 1.46

5.76E-01 5.51E-01 1.68E-01 3.52E-01 5.32E-02

1.08 1.46 1.49 1.15 1.15

7.32E-01 4.33E-01 4.15E-02 4.66E-01 4.03E-01

1.16

2.99E-01

0.87

3.27E-02

1.14

2.07E-01

1.00

9.70E-01

1.34

3.00E-01

0.89

2.98E-01

0.74 0.82 1.37

1.25E-03 1.63E-02 3.06E-01

1.05 1.12 0.75

6.78E-01 8.74E-02 5.58E-03

1.62 1.11 0.98

6.69E-02 1.62E-02 9.34E-01

selB selA selD

MSMEG_1853 Na+/H+ antiporter NhaA; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF06965 MSMEG_1853 Na+/H+ antiporter NhaA; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF06965 MSMEG_1854 valosin containing protein-1 MSMEG_1855 tetratricopeptide repeat protein, putative MSMEG_1856 hypothetical protein MSMEG_1859 hypothetical protein MSMEG_1860 hypothetical protein MSMEG_1861 hypothetical protein MSMEG_1862 transposase MSMEG_1862 transposase MSMEG_1863 putative transposase MSMEG_1863 putative transposase MSMEG_1864 transposase MSMEG_1866 transposase B MSMEG_1867 transposase MSMEG_1868 hypothetical protein MSMEG_1869 hypothetical protein MSMEG_1870 conserved hypothetical protein MSMEG_1871 conserved hypothetical protein MSMEG_1872 conserved hypothetical protein MSMEG_1873 thymidylate kinase mtrA MSMEG_1874 DNA-binding response regulator MtrA MSMEG_1875 sensor histidine kinase MtrB MSMEG_1876 LpqB protein MSMEG_1877 conserved hypothetical protein MSMEG_1878 S30AE family protein MSMEG_1879 hypothetical protein MSMEG_1880 hypothetical alanine arginine proline rich protein secA MSMEG_1881 preprotein translocase, SecA subunit MSMEG_1882 acyltransferase, ws/dgat/mgat subfamily protein MSMEG_1883 glycine betaine transporter OpuD MSMEG_1884 conserved hypothetical protein

1.19

2.11E-01

1.22

2.10E-02

0.90

7.90E-02

0.97 0.89 1.03 0.84 0.91 1.17 0.39 0.40 0.55 0.62 0.52 1.12 0.64 0.59 0.58 0.82 0.78 0.57 0.59 0.39 0.98 1.47 0.67 1.36 2.75 1.20 1.21 1.05 0.89 1.67 0.48


0.91 1.34 1.04 1.17 1.21 1.32 1.43 1.21 0.89 1.26 1.06 1.21 1.30 0.98 1.08 1.13 1.21 1.19 1.28 1.22 1.11 2.08 1.22 1.07 1.21 1.35 1.80 0.84 0.97 0.76 0.78


1.10 0.72 0.89 0.93 1.11 1.12 1.21 1.86 0.98 0.76 0.93 1.00 1.11 0.79 0.38 0.72 0.91 0.81 0.53 1.18 1.22 1.84 2.46 3.57 1.95 1.09 0.92 0.93 1.08 0.73 1.10



2Fe-2S iron-sulfur cluster binding domain protein Fatty acid desaturase hypothetical protein methyltransferase putative ribosome small subunit-dependent GTPase RsgA 3-phosphoshikimate 1-carboxyvinyltransferase conserved hypothetical protein transferase UbiE/COQ5 methyltransferase short chain dehydrogenase HTH-type transcriptional regulator AlsR beta-ketothiolase 3-oxoadipate enol-lactonase succinyl-CoA:3-ketoacid-coenzyme A transferase 1, precursor succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B D-alanyl-D-alanine carboxypeptidase family protein D-alanyl-D-alanine carboxypeptidase family protein DNA-binding HTH domain containing protein, putative transcriptional regulator caib/baif family protein acyl-CoA dehydrogenase acyl-CoA dehydrogenase protein toluate 1,2-dioxygenase electron transfer component toluate 1,2-dioxygenase beta subunit benzoate 1,2-dioxygenase alpha subunit putative HTH-type transcriptional regulator YnfL muconate cycloisomerase catechol 1,2-dioxygenase muconolactone delta-isomerase 1 YbaK/ebsC protein RNA polymerase sigma-70 factor, family protein

aroA

pcaD

catA ybaK

0.58 0.54 2.98 1.37

1.63E-02 2.53E-02 4.17E-04 5.77E-02

1.31 2.09 0.58 0.72

5.82E-01 9.96E-03 1.36E-02 1.55E-02

0.96 0.29 0.72 1.64

8.96E-01 2.43E-04 1.21E-01 1.24E-01

0.62 0.64 1.46 0.64 1.39 1.51 0.95 3.22 2.56

1.94E-03 5.24E-04 7.23E-04 4.44E-02 1.57E-02 8.66E-03 5.86E-01 3.24E-02 3.50E-02

1.13 1.00 1.01 0.89 0.75 1.04 1.29 0.84 0.82

6.46E-03 9.62E-01 9.05E-01 9.47E-02 3.26E-02 6.90E-01 3.55E-01 4.19E-01 6.87E-02

1.37 1.68 1.31 1.28 0.92 0.48 0.97 1.14 0.83

4.30E-01 3.33E-02 2.69E-01 2.41E-02 6.15E-01 4.12E-04 2.61E-01 3.22E-01 1.94E-01

3.90

1.45E-02

0.75

1.71E-04

0.81

3.00E-01

3.26

2.19E-02

0.66

3.38E-03

1.04

3.19E-01

0.70

1.26E-02

0.81

1.83E-02

1.27

2.81E-01

0.77

5.30E-02

1.05

6.34E-01

0.93

5.46E-01

1.38 1.25 3.40 4.95 3.59

1.01E-04 1.60E-03 8.21E-04 1.32E-02 1.24E-02

1.23 0.86 0.71 0.77 0.82

4.18E-02 2.37E-01 6.00E-03 7.65E-02 1.05E-01

1.48 1.06 1.00 0.92 1.01

9.98E-02 5.00E-01 9.65E-01 4.85E-01 9.25E-01

5.86 5.14 4.99 2.56 3.01 2.94 2.02 0.46 1.85

1.40E-01 5.26E-02 4.56E-02 1.31E-02 1.37E-02 6.26E-04 1.01E-03 1.61E-03 9.56E-04

1.22 1.59 1.31 0.91 0.71 0.98 1.02 1.30 1.11

7.77E-02 8.89E-02 1.00E-02 4.60E-01 7.16E-03 8.99E-01 7.94E-01 2.56E-01 2.83E-01

0.59 0.31 1.14 0.88 1.04 0.25 0.72 1.59 0.63

1.48E-02 2.27E-03 8.15E-01 1.43E-01 8.77E-01 1.64E-04 1.74E-01 1.44E-01 1.89E-02


anti-sigma factor, family protein hypothetical protein conserved domain protein sensor histidine kinase Transcription factor WhiB diacylglycerol kinase, catalytic region SEC-C motif domain protein 3-dehydroquinate dehydratase, type II membrane protein N-acetyltransferase Ats1 isochorismate synthase DhbC phosphoglycerate mutase family protein cobyrinic Acid a,c-diamide synthase regulatory protein conserved hypothetical protein DEAD/DEAH box helicase conserved hypothetical protein MmpS3 protein hypothetical protein ATP-binding protein TetR-family protein transcriptional regulator conserved hypothetical protein molybdopterin biosynthesis protein MoeB conserved hypothetical protein 6-O-methylguanine DNA methyltransferase, DNA binding domain subfamily protein hydrolase, alpha/beta fold family protein helicase, UvrD/Rep family protein integral membrane protein ATP-dependent DNA helicase membrane protein ion channel membrane protein NADH pyrophosphatase conserved hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved domain protein

aroQ

1.10 1.24 0.43 0.65 0.59 0.33 0.68 0.46 0.51 0.65 0.45 0.86 1.18 1.67 0.49 2.00 1.05 1.49 0.93 1.21 1.00 1.13 1.35 0.71


0.96 0.72 1.45 2.22 0.62 0.98 1.04 1.33 1.47 0.97 1.09 0.77 0.89 1.03 1.06 0.97 0.81 0.74 0.84 0.86 0.81 0.75 1.11 2.46


1.79 1.73 0.83 1.13 8.33 2.48 1.78 1.62 1.42 2.99 1.27 2.03 0.69 1.65 3.13 1.15 0.91 1.27 0.93 1.03 0.96 0.97 1.19 1.13


1.24 2.65 0.98 1.38 0.61 1.77 0.50 0.56 1.18 1.30 0.94 2.50 1.49

1.80E-01 3.30E-01 9.09E-01 8.95E-02 6.83E-02 3.46E-03 2.36E-05 2.24E-04 1.67E-01 2.23E-01 3.02E-01 3.34E-01 5.00E-01

1.07 1.46 1.63 0.95 1.33 1.01 1.10 1.03 0.92 0.97 1.50 1.64 2.30

3.39E-01 5.00E-01 2.24E-01 3.60E-01 3.03E-01 9.45E-01 7.05E-02 5.11E-01 6.00E-01 8.95E-01 1.05E-01 4.59E-02 5.65E-02

1.64 1.15 2.94 1.69 2.19 0.72 1.52 1.12 1.69 0.94 1.05 1.17 0.90

1.02E-01 4.46E-01 7.16E-02 5.07E-02 4.15E-02 8.61E-04 5.62E-02 4.91E-01 5.99E-02 4.59E-01 2.75E-01 6.12E-01 5.53E-01


ATP-dependent DNA helicase transcription factor WhiB ABC1 family protein conserved hypothetical protein hypothetical protein conserved hypothetical protein PDZ domain family protein putative membrane protein hypothetical protein conserved hypothetical protein hypothetical protein putative transcriptional regulatory protein mitomycin radical oxidase hypothetical protein TetR-family protein transcriptional regulator putative oxidoreductase MerR-family protein transcriptional regulator sigma factor propane monooxygenase hydroxylase large subunit methane monooxygenase component C propane monooxygenase hydroxylase small subunit; this gene contains a frame shift which is not the result of sequencing error propane monooxygenase hydroxylase small subunit; this gene contains a frame shift which is not the result of sequencing error propane monooxygenase coupling protein amidohydrolase 2 conserved hypothetical protein alcohol dehydrogenase groL chaperonin GroL antibiotic biosynthesis monooxygenase monooxygenase conserved hypothetical protein acyl-CoA synthase major facilitator family protein transporter haloacetate dehalogenase H-1

0.73 0.78 0.94 0.40 0.61 1.21 0.50 1.05 1.20 1.06 1.00 0.70 0.81 6.06 0.84 0.84 1.91 13.23


0.94 1.65 0.78 1.18 1.47 0.96 1.18 0.82 1.05 1.12 1.05 1.02 1.10 0.60 1.03 1.21 0.76 1.10


1.49 1.54 0.59 1.39 0.99 1.44 0.93 0.58 0.74 0.65 0.86 1.14 1.19 8.28 1.55 1.43 1.42 0.87


50.66 30.92

3.66E-02 2.32E-02

1.17 1.92

3.27E-01 1.26E-01

0.08 0.07

3.09E-06 4.55E-06

22.81

1.05E-02

1.62

6.75E-02

0.04

2.51E-07

40.06 24.98 37.86 20.54 17.87 20.61 17.86 1.92 1.90 1.08 3.10 9.82

4.09E-02 2.67E-02 2.13E-02 2.07E-02 1.93E-02 1.28E-02 3.64E-02 8.93E-03 1.18E-03 7.80E-01 7.71E-02 4.61E-03

1.45 1.57 1.72 1.22 1.30 1.21 1.50 0.81 0.76 1.17 2.07 0.80

7.56E-02 2.82E-01 1.19E-01 1.74E-01 2.16E-01 2.99E-01 1.14E-01 7.13E-02 4.18E-02 2.67E-01 4.48E-01 1.50E-01

0.07 0.04 0.03 0.07 0.08 0.07 0.14 0.57 0.54 0.88 1.40 0.90

6.17E-06 3.52E-07 4.84E-08 7.48E-06 1.39E-05 4.57E-06 7.17E-05 4.47E-03 1.89E-03 3.60E-01 1.78E-01 1.45E-01


transcriptional regulator, LysR family protein tartrate dehydrogenase conserved hypothetical protein conserved hypothetical protein phenoxybenzoate dioxygenase beta subunit conserved hypothetical protein isovaleryl-CoA dehydrogenase L-carnitine dehydratase/bile acid-inducible protein F MaoC like domain protein HpcH/HpaI aldolase transcriptional regulator MdcY family protein N5,N10- methylenetetrahydromethanopterin reductase-related protein N-acyl-D-glutamate amidohydrolase hydrolase, alpha/beta fold family protein hypothetical protein conserved hypothetical protein sugar transporter arabinose-proton symporter sugar phosphate isomerase/epimerase 2,3-dihydroxybiphenyl 1,2-dioxygenase putative HpcE protein hypothetical protein regulatory protein GntR, HTH:GntR, Cstress responsive A/B Barrel Domain superfamily protein transcriptional regulator, LacI family protein hisD histidinol dehydrogenase oxidoreductase, short chain dehydrogenase/reductase family protein molybdenum import ATP-binding protein ModC modB molybdate ABC transporter, permease protein molybdate ABC transporter, periplasmic modA molybdate-binding protein transcriptional regulator, MerR family protein

3.36 11.95 1.38 1.05 0.82 1.32 0.87

3.39E-03 2.29E-03 3.33E-01 8.62E-01 3.59E-01 2.10E-01 3.85E-01

0.79 0.59 0.71 0.73 0.77 0.83 1.07

3.76E-02 3.41E-02 1.97E-01 1.04E-01 5.55E-02 5.70E-01 3.10E-01

1.20 0.92 2.36 1.03 1.05 1.03 0.97

4.58E-01 8.18E-01 1.28E-01 5.85E-01 5.62E-01 5.33E-01 2.58E-01

0.96 0.76 0.69 0.82

7.90E-01 4.47E-02 9.32E-03 2.27E-02

1.12 1.14 1.18 0.97

7.06E-01 3.92E-02 1.00E-01 6.60E-01

1.04 1.00 0.96 0.57

6.58E-01 9.06E-01 4.65E-01 2.18E-03

1.48 1.25 1.17 0.72 1.41 1.03 1.13 1.24 3.57 3.51 1.09 1.41

3.05E-03 6.27E-02 3.02E-01 7.30E-02 3.17E-01 8.75E-01 3.64E-01 2.11E-01 5.96E-03 5.78E-03 7.78E-01 3.43E-02

0.92 1.26 1.12 0.71 1.22 1.07 1.04 1.09 0.90 0.78 1.08 0.92

2.11E-01 4.32E-02 3.86E-01 2.27E-02 4.60E-01 5.59E-01 6.70E-01 3.65E-01 4.55E-01 1.33E-01 5.13E-01 2.21E-01

0.74 0.56 0.65 4.41 0.78 1.23 0.92 1.05 0.73 0.83 0.94 1.03

1.08E-02 2.99E-03 4.32E-04 5.11E-02 7.72E-02 4.18E-01 2.93E-01 5.30E-01 1.55E-01 4.25E-01 4.40E-01 7.53E-01

0.30 0.95 0.76

2.10E-04 7.66E-01 1.78E-01

0.87 1.04 1.53

4.39E-01 7.62E-01 2.21E-01

2.10 1.10 0.97

1.49E-01 4.00E-01 4.35E-01

1.20 0.28 0.10

4.32E-01 1.50E-03 8.87E-07

1.20 2.16 3.49

3.52E-01 5.00E-02 6.45E-03

0.99 3.94 3.59

3.12E-01 1.16E-02 1.80E-02

0.29 0.27

4.28E-05 6.86E-06

1.93 2.25

1.73E-02 2.99E-03

1.57 1.83

3.46E-02 3.94E-03

MSMEG_2018 cytochrome P450 107B1; this gene contains a frame shift which is not the result of sequencing error MSMEG_2019 short-chain dehydrogenase/reductase SDR MSMEG_2020 hyi family protein, authentic frameshift; this gene contains a frame shift which is not the result of sequencing error; identified by similarity to RF:NP_457306.1 MSMEG_2021 lipopolysaccharide biosynthesis acyltransferase, M MSMEG_2022 GntT protein, putative MSMEG_2023 CAIB/BAIF family protein MSMEG_2024 hydroxymethylglutaryl-CoA lyase MSMEG_2025 putative IclR family protein transcriptional regulator MSMEG_2026 short chain dehydrogenase MSMEG_2027 conserved hypothetical protein TIGR00026 MSMEG_2028 chloramphenicol resistance protein MSMEG_2029 3-ketoacyl-ACP/CoA redutase MSMEG_2030 transcriptional regulator, TetR family protein MSMEG_2031 hypothetical protein MSMEG_2032 conserved hypothetical protein MSMEG_2033 oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_2034 aryl-alcohol dehydrogenase MSMEG_2035 amine oxidase [flavin-containing] B MSMEG_2036 hydrolase, alpha/beta fold family protein MSMEG_2037 conserved hypothetical protein MSMEG_2038 monooxygenase, flavin-binding family protein MSMEG_2039 putative transcriptional regulator MSMEG_2040 hypothetical protein MSMEG_2041 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2042 phosphotransferase enzyme family protein MSMEG_2043 transcriptional regulator, TetR family protein MSMEG_2044 integral membrane transport protein MSMEG_2045 monoxygenase

1.01 0.59

8.99E-01 5.24E-05

1.29 0.89

3.72E-01 7.69E-02

1.20 1.08

3.90E-01 6.74E-01

0.79

4.35E-03

1.07

5.98E-01

0.83

2.22E-01

0.57 1.79 1.63 1.79

1.00E-03 1.42E-01 1.44E-01 4.95E-02

1.05 0.82 0.95 1.09

4.16E-01 7.14E-02 6.03E-01 4.35E-01

1.16 0.98 1.17 0.92

3.42E-01 8.76E-01 1.90E-01 1.49E-01

0.98 0.58 2.84 0.90 0.92 1.29 1.33 1.54

8.24E-01 2.00E-04 5.92E-03 3.85E-01 6.60E-01 6.81E-02 2.27E-01 7.71E-03

1.24 0.89 1.41 1.49 1.07 0.95 1.09 0.84

2.67E-01 2.34E-01 3.75E-01 7.20E-02 6.38E-01 6.84E-01 5.03E-01 1.27E-01

0.75 1.30 0.59 1.06 0.98 1.44 1.17 1.50

7.41E-02 1.44E-03 5.26E-02 1.94E-01 3.75E-01 1.24E-01 3.48E-01 7.63E-02

0.51 1.27 0.95 1.60 0.41 1.00 1.43 0.89

4.32E-04 2.80E-01 7.53E-01 6.06E-02 1.72E-04 9.82E-01 3.43E-02 7.14E-02

1.05 0.92 1.39 1.01 1.04 1.27 0.87 1.25

5.26E-01 4.90E-01 6.67E-02 9.68E-01 7.36E-01 8.37E-02 3.34E-01 2.85E-01

3.38 0.99 0.64 0.98 1.00 0.58 0.98 1.81

1.47E-02 7.28E-01 1.74E-02 8.95E-01 9.86E-01 7.51E-06 8.25E-01 4.02E-01

1.03 1.18 1.06 0.63 0.50

7.32E-01 5.02E-03 8.53E-01 2.05E-02 1.18E-05

0.97 1.01 2.08 1.36 1.30

7.28E-01 8.42E-01 1.87E-01 4.06E-01 2.86E-01

0.55 0.53 1.81 5.28 2.37

3.22E-02 2.07E-02 2.31E-01 1.00E-02 2.85E-03


GlcNAc-PI de-N-acetylase family protein probable enoyl-CoA hydratase alcohol dehydrogenase putative transcriptional regulator, TetR family protein NADH-quinone oxidoreductase, N subunit NADH-quinone oxidoreductase, M subunit NADH-quinone oxidoreductase, L subunit NADH-quinone oxidoreductase, k subunit NADH dehydrogenase subunit j NADH-quinone oxidoreductase, I subunit NADH-quinone oxidoreductase, H subunit NADH-quinone oxidoreductase, G subunit NADH-quinone oxidoreductase, F subunit NADH-quinone oxidoreductase chain e NADH-quinone oxidoreducatase, D subunit NADH-quinone oxidoreductase chain c NADH-quinone oxidoreductase, B subunit NADH-quinone oxidoreductase, a subunit two-component system response regulator YceI like family protein conserved hypothetical protein methyltransferase type 12 hypothetical protein phosphotransferase enzyme family protein acyl-CoA dehydrogenase family protein transcriptional regulator, TetR family protein 3-hydroxy-3-methylglutaryl-CoA lyase CAIB/BAIF family protein conserved hypothetical protein homogentisate 1,2-dioxygenase conserved hypothetical protein acyl-CoA dehydrogenase, C- domain protein antigen 85-C alcohol dehydrogenase putative acyl-CoA dehydrogenase putative acyl-CoA dehydrogenase hypothetical protein

nuoN nuoM nuoL nuoK nuoI nuoH nuoG nuoF nuoD nuoB nuoA

hmgA

0.64 0.80 0.95

2.80E-02 9.60E-02 4.50E-01

1.07 1.61 0.91

1.43E-01 3.45E-01 1.70E-01

2.13 0.81 1.31

9.88E-02 1.10E-01 3.08E-01

1.24 3.39 4.27 3.46 4.95 4.47 2.36 6.08 5.15 19.12 4.18 4.90 3.14 7.69 6.64 3.97 1.57 1.28 1.31 1.22 1.22 1.52 1.50 1.40 0.89 0.66 1.33 1.08 0.83 2.47 1.08 1.33 1.43 1.22

1.72E-01 6.76E-02 2.18E-02 3.07E-02 1.88E-02 9.87E-02 1.57E-01 1.03E-01 3.28E-02 3.96E-02 3.31E-02 1.09E-01 5.33E-02 4.44E-02 7.99E-02 3.26E-03 3.25E-02 1.88E-01 5.52E-02 4.27E-02 7.85E-02 1.80E-02 1.77E-01 6.06E-02 4.65E-02 3.47E-03 2.43E-03 4.15E-01 1.13E-01 9.30E-04 5.65E-01 1.38E-01 8.36E-02 2.80E-01

1.22 0.97 0.99 0.84 0.85 0.86 1.04 1.02 1.01 0.77 1.10 0.68 1.06 0.76 0.91 0.76 1.02 0.91 1.13 0.87 0.79 0.84 1.16 0.72 0.94 0.97 0.94 1.20 0.98 0.73 0.72 0.71 0.77 0.44


0.93 0.45 0.19 0.50 0.12 0.19 0.73 0.24 0.10 0.10 0.22 0.50 0.16 0.16 0.75 0.59 0.95 1.43 1.09 1.93 1.88 1.11 1.10 1.60 1.14 0.64 0.48 1.36 1.06 0.60 1.88 2.87 2.20 1.03


MSMEG_2083 inositol monophosphatase MSMEG_2084 conserved hypothetical protein MSMEG_2085 NADPH-ferredoxin reductase fpra; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF07992 MSMEG_2086 peptide chain release factor 2 MSMEG_2087 transporter, small conductance mechanosensitive ion channel (MscS) family protein MSMEG_2088 hypothetical proline-rich protein MSMEG_2089 cell division ATP-binding protein FtsE MSMEG_2090 putative cell division protein FtsX MSMEG_2091 SsrA-binding protein MSMEG_2092 D-aminopeptidase MSMEG_2094 56kDa selenium binding protein MSMEG_2095 serine esterase, cutinase family protein MSMEG_2096 integral membrane protein MSMEG_2097 Acyl-coenzyme A:6-aminopenicillanic acid acyltransferase MSMEG_2098 fumarylacetoacetate hydrolase family protein MSMEG_2099 ABC transporter, substrate binding protein [nitrate/sulfonate], putative MSMEG_2100 peptidase family protein M20/M25/M40 MSMEG_2101 taurine ABC transporter, permease protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00528 MSMEG_2102 nitrate transport ATP-binding protein NrtD MSMEG_2103 5,10-methylenetetrahydromethanopterin MSMEG_2104 GntR-family protein transcriptional regulator MSMEG_2105 ATP dependent DNA ligase MSMEG_2106 putative transcriptional regulator MSMEG_2107 conserved hypothetical protein MSMEG_2108 conserved hypothetical protein MSMEG_2109 conserved hypothetical protein MSMEG_2110 conserved hypothetical protein MSMEG_2111 chorismate mutase MSMEG_2112 secreted protein

hisN

prfB

ftsE smpB

0.55 1.15

1.49E-04 1.43E-01

1.26 0.90

5.29E-01 1.71E-01

1.37 1.82

3.13E-01 8.23E-03

1.89 0.70

3.90E-04 3.08E-03

0.90 1.08

7.98E-02 3.17E-01

0.82 1.50

8.62E-02 8.10E-02

0.62 0.70 0.54 0.47 0.52 1.23 1.23 1.69 1.00

1.03E-03 1.24E-03 4.12E-04 1.89E-04 1.29E-04 3.66E-02 1.78E-01 4.40E-03 9.78E-01

0.81 0.78 0.73 0.95 0.96 1.08 0.94 1.08 1.07

5.36E-02 1.28E-02 6.00E-03 4.68E-01 6.60E-01 2.05E-01 4.26E-01 3.23E-01 3.15E-01

1.95 2.40 1.58 1.34 1.50 0.31 1.08 0.46 0.73

4.50E-02 3.09E-02 9.18E-02 1.87E-01 3.61E-01 5.22E-06 4.33E-01 1.11E-05 2.58E-02

1.48 0.81

4.49E-01 4.62E-01

1.28 1.07

4.27E-02 4.83E-01

0.91 1.38

2.15E-01 3.90E-01

0.77 0.63

4.11E-01 5.75E-03

1.73 1.28

2.22E-01 2.94E-01

1.29 1.00

4.58E-01 9.19E-01

0.93 0.78 1.64 1.15 1.25 0.96 0.98 1.27 1.13 1.26 1.18 1.13

2.48E-01 3.70E-02 2.36E-01 4.14E-01 5.37E-02 6.48E-01 8.20E-01 8.81E-02 2.88E-01 6.03E-03 4.46E-02 5.85E-01

1.06 0.97 0.90 0.97 1.08 0.94 1.16 1.13 0.91 0.77 0.87 1.88

5.97E-01 7.95E-01 8.78E-02 7.80E-01 5.20E-01 3.38E-01 1.71E-01 2.79E-01 1.20E-01 2.41E-02 3.08E-01 6.17E-02

2.79 1.00 1.09 0.95 0.91 1.33 0.49 1.05 0.80 0.52 0.51 0.40

3.57E-01 9.91E-01 3.23E-01 4.04E-03 3.45E-01 3.38E-01 3.65E-03 6.46E-01 1.89E-01 1.64E-03 1.41E-02 9.75E-04


hypothetical protein glucose-6-phosphate isomerase, putative conserved hypothetical protein PTS system, glucose-specific IIBC component beta-glucoside-specific EII permease nagB glucosamine-6-phosphate isomerase nagA N-acetylglucosamine-6-phosphate deacetylase tetratricopeptide repeat family protein multiphosphoryl transfer protein (MTP) dihydroxyacetone kinase, L subunit dhaK dihydroxyacetone kinase, DhaK subunit glycerol uptake facilitator, MIP channel glycerol operon regulatory protein hypothetical protein conserved hypothetical protein malonyl CoA decarboxylase hypothetical protein putative acyl-CoA dehydrogenase acyl-CoA synthase acyl carrier protein Acp conserved hypothetical protein, putative crcB CrcB protein putative CrcB protein phosphoglucomutase, alpha-D-glucose phosphatepgm specific permease of the major facilitator superfamily protein hypothetical protein Fic protein family protein gp35 protein gp36 protein hypothetical protein conserved hypothetical protein conserved domain protein gp15 protein gp16 protein; this gene contains a frame shift which is not the result of sequencing error HNH endonuclease domain protein

0.74 0.53 1.31 0.47 0.54 0.38 0.38 0.93 0.55 0.69 0.69 0.51 0.62 0.82 1.54 0.85 1.38 0.43 0.24 0.60 0.89 0.98 1.11


1.43 1.04 2.18 1.12 1.19 1.02 1.01 1.12 3.27 3.41 3.26 8.08 1.09 1.09 1.01 0.99 1.01 1.10 1.16 0.96 1.11 0.92 1.01


1.24 1.19 0.48 0.33 0.39 0.60 0.92 1.21 0.91 0.83 0.46 1.06 1.00 1.09 1.09 1.30 1.13 2.96 3.28 2.13 1.56 1.11 1.16


1.00

9.90E-01

0.98

7.89E-01

0.72

8.68E-03

0.44 0.92 0.82 1.46 1.67 1.57 2.45 1.31 1.19

7.53E-05 5.98E-01 1.33E-01 1.92E-02 5.31E-02 9.69E-03 4.26E-04 1.06E-01 3.23E-01

1.07 0.98 1.05 1.25 0.87 0.89 1.03 0.88 1.15

4.35E-01 7.50E-01 5.13E-01 3.74E-01 1.94E-01 2.68E-01 7.69E-01 9.59E-02 4.43E-01

1.74 1.03 1.02 1.24 0.88 1.15 0.64 1.77 1.11

3.34E-01 6.27E-01 8.92E-01 2.56E-01 2.18E-01 3.11E-01 2.81E-03 3.94E-01 6.30E-01

1.16 2.04

1.12E-01 2.36E-02

1.16 0.95

6.28E-01 6.97E-01

0.88 1.05

3.64E-01 3.70E-01

MSMEG_2149 MSMEG_2150 MSMEG_2150 MSMEG_2151 MSMEG_2151 MSMEG_2152 MSMEG_2153 MSMEG_2154 MSMEG_2155 MSMEG_2156 MSMEG_2157 MSMEG_2158 MSMEG_2159 MSMEG_2160 MSMEG_2161 MSMEG_2161 MSMEG_2161 MSMEG_2162 MSMEG_2163 MSMEG_2164 MSMEG_2165 MSMEG_2166 MSMEG_2167 MSMEG_2168 MSMEG_2169 MSMEG_2170 MSMEG_2171

hypothetical protein putative transposition helper protein putative transposition helper protein transposase IstA protein, putative transposase IstA protein, putative hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative transcriptional regulator, TetR family protein conserved hypothetical protein trans-2-enoyl-CoA reductase conserved hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein hypothetical protein FadD9 protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error FadD9 protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error FadD9 protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MmcJ protein aldehyde dehydrogenase transcriptional regulator, putative transketolase, N- subunit transketoloase, C half aminopeptidase, putative hypothetical protein acetyl-CoA carboxylase, carboxyl transferase, accD beta subunit 3-hydroxyisobutyrate dehydrogenase family protein L-carnitine dehydratase/bile acid-inducible protein F

2.52 1.37 0.89 0.70 0.90

3.33E-03 1.38E-01 5.93E-01 2.13E-02 5.81E-01

1.02 1.60 1.21 2.44 1.58

9.12E-01 6.95E-02 5.26E-01 6.27E-02 1.75E-01

0.78 0.97 1.29 0.88 0.99

1.28E-01 3.82E-01 3.87E-01 2.50E-01 2.64E-01

1.49 1.30 1.08 1.10 1.42 2.06 0.93 2.89 1.60

1.83E-01 4.94E-02 7.35E-01 4.27E-01 3.19E-02 6.46E-02 6.80E-01 1.96E-02 4.01E-02

1.70 1.50 1.48 0.89 1.00 0.68 1.00 0.66 1.62

9.40E-02 2.05E-01 1.54E-01 9.38E-02 9.82E-01 1.86E-03 9.93E-01 1.12E-02 1.39E-02

2.59 0.83 1.48 1.46 1.04 1.09 0.98 0.90 1.01

3.22E-01 2.01E-01 4.23E-01 4.36E-01 2.84E-01 6.27E-01 5.09E-01 1.77E-01 9.27E-01

1.95

7.61E-03

0.86

6.53E-02

1.33

5.07E-02

1.53

3.33E-02

1.29

9.96E-02

3.61

1.95E-01

0.92 0.46 0.75 0.56 1.26 1.17 1.18 0.87

3.21E-01 2.02E-03 3.55E-03 2.50E-05 1.90E-01 3.87E-01 1.80E-01 2.67E-01

1.04 1.02 0.93 0.83 0.95 0.90 1.43 1.16

7.10E-01 7.82E-01 4.46E-01 2.45E-02 7.48E-01 2.71E-01 2.83E-01 1.49E-01

1.01 0.83 1.03 2.43 1.08 0.94 1.00 1.17

9.06E-01 1.37E-01 8.28E-01 4.25E-02 4.59E-02 6.24E-01 9.67E-01 4.76E-01

1.72

1.43E-01

1.10

6.93E-01

18.25

5.77E-02

0.91

7.93E-02

0.90

1.88E-01

2.17

1.11E-01

3.31

1.06E-01

0.86

2.39E-01

34.20

4.86E-02


dicarboxylate-carrier protein GntR-family protein transcriptional regulator superfamily protein I DNA or RNA helicase nitrilotriacetate monooxygenase component A conserved hypothetical protein fmnh2-utilizing oxygenase integral membrane protein transcriptional regulatory protein RemK protein cell filamentation protein transcriptional regulator conserved hypothetical protein amino acid permease conserved hypothetical protein conserved hypothetical protein urea amidolyase integral membrane protein allophanate hydrolase acyl-CoA dehydrogenase domain protein acyl-CoA dehydrogenase family protein conserved hypothetical protein transcriptional regulator, TetR family protein MerR-family protein transcriptional regulator transcriptional regulator, TetR family protein sensory box/response regulator hypothetical protein ThiF family protein conserved hypothetical protein formyltetrahydrofolate deformylase ZbpA protein dimethylaniline monooxygenase [N-oxideforming] 5 alpha/beta hydrolase carveol dehydrogenase ((+)-trans-carveol dehydrogenase) putative acyl-CoA dehydrogenase 3-oxoacyl-(acyl-carrier-protein) reductase beta-ketothiolase

atzF

purU

fabG

5.88 1.43 0.71 3.53 0.87 5.18 1.23 1.68 1.45 0.99 0.69 1.86 1.03 0.80 0.94 0.83 0.82 0.73 2.07 1.69 1.97 1.20 32.00 7.06 1.24 0.92 1.38 3.09 0.46 1.02

4.75E-02 1.76E-02 5.43E-04 1.04E-02 1.16E-01 1.54E-02 2.63E-01 4.87E-03 2.17E-01 9.33E-01 1.58E-03 7.62E-02 9.37E-01 4.41E-02 6.84E-01 5.69E-02 2.39E-01 3.99E-03 1.53E-01 2.53E-01 9.77E-03 5.83E-02 3.23E-02 2.79E-01 4.76E-02 5.04E-01 4.46E-02 5.57E-05 4.36E-04 7.23E-01

0.99 0.84 0.85 1.06 0.94 1.34 1.66 0.98 1.18 1.19 0.94 0.97 1.25 1.01 1.17 0.80 1.69 0.74 1.16 1.41 0.82 0.86 4.51 0.98 1.02 1.01 1.13 1.00 1.04 0.99


0.08 1.59 1.57 0.84 2.47 0.85 0.97 1.84 1.08 0.99 3.06 1.02 0.97 0.80 0.83 1.60 1.14 1.03 1.04 1.20 0.77 1.24 2.12 1.57 7.43 2.40 1.60 0.27 1.66 0.68


0.49 0.90

5.36E-05 4.96E-01

1.16 1.08

1.85E-01 3.93E-01

0.42 2.03

7.65E-03 3.80E-01

1.28 1.54 1.33 0.78

8.57E-02 3.97E-01 1.04E-01 3.73E-02

0.85 0.74 0.74 0.71

1.83E-02 8.73E-02 5.42E-03 6.38E-03

1.04 1.24 1.91 2.34

7.88E-01 1.31E-01 2.68E-01 2.24E-01

MSMEG_2208 acyl-CoA dehydrogenase MSMEG_2209 transcriptional regulator, GntR family protein MSMEG_2210 CaiB/BaiF family protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2210 CaiB/BaiF family protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2211 DNA-binding protein MSMEG_2212 short chain dehydrogenase MSMEG_2213 O-methyltransferase MSMEG_2214 alcohol dehydrogenase B; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_2215 AMP-binding enzyme MSMEG_2216 AMP-binding enzyme MSMEG_2217 AMP-dependent synthetase and ligase MSMEG_2218 enoyl-CoA hydratase/isomerase family protein MSMEG_2219 enoyl-CoA hydratase/isomerase family protein MSMEG_2220 enoyl-CoA hydratase/isomerase MSMEG_2222 hypothetical protein MSMEG_2222 hypothetical protein MSMEG_2223 enoyl-CoA hydratase/isomerase family protein MSMEG_2224 acetyl-CoA C-acyltransferase MSMEG_2225 transcriptional regulator, TetR family protein MSMEG_2226 hypothetical protein MSMEG_2227 carnitinyl-CoA dehydratase MSMEG_2228 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_2229 enoyl-CoA hydratase MSMEG_2230 amidohydrolase family protein MSMEG_2231 AMP-binding enzyme MSMEG_2232 amidohydrolase family protein MSMEG_2233 acyl-CoA dehydrogenase, C- domain protein MSMEG_2234 acyl-CoA dehydrogenase, middle domain protein MSMEG_2235 amidohydrolase family protein MSMEG_2236 putative thiolase MSMEG_2237 anaerobic dehydrogenase, typically

0.80 0.90

2.49E-02 3.96E-01

0.70 0.99

1.38E-03 9.42E-01

2.05 2.21

1.19E-01 2.24E-01

0.94

1.92E-01

0.94

2.28E-01

2.49

2.30E-01

1.19 2.29 1.00 1.15

2.44E-01 1.48E-02 9.75E-01 1.60E-01

1.04 0.89 1.09 1.24

2.99E-01 3.09E-01 3.75E-01 1.74E-01

1.17 1.39 0.93 1.20

2.99E-01 1.30E-01 3.30E-01 3.01E-01

1.43 1.10 1.03 1.79 1.49 0.84 1.39 1.57 1.03 0.90 0.91 1.05 1.41 0.94

7.55E-02 4.28E-01 8.61E-01 1.22E-01 2.78E-01 1.02E-02 3.28E-01 7.28E-02 8.33E-01 1.30E-01 6.21E-01 1.94E-01 4.04E-04 5.90E-01

1.03 1.03 1.13 1.11 1.04 0.96 0.98 1.12 0.94 1.30 1.01 1.01 0.93 1.00

8.23E-01 8.69E-01 3.31E-01 4.29E-01 6.27E-01 5.76E-01 7.05E-01 4.84E-01 7.11E-01 3.52E-01 8.48E-01 8.33E-01 4.38E-01 9.93E-01

1.48 1.01 1.10 1.01 1.00 1.20 1.02 1.13 1.01 1.62 1.37 0.99 0.94 1.06

1.98E-01 8.06E-01 2.98E-01 5.01E-01 9.51E-01 2.82E-01 8.90E-01 4.70E-02 7.07E-01 2.41E-01 2.01E-01 9.46E-01 4.66E-01 3.16E-01

0.78 1.75 1.02 1.11 0.84 1.47 0.93 1.34 1.07 1.48

2.31E-02 1.59E-01 8.29E-01 4.19E-01 6.27E-02 3.93E-01 5.94E-01 1.51E-01 2.04E-01 1.97E-01

1.14 1.34 1.02 0.88 1.21 1.27 1.20 1.02 0.96 1.22

4.18E-01 2.78E-02 8.11E-01 3.18E-01 3.70E-01 3.61E-01 2.89E-01 8.93E-01 4.72E-01 1.32E-01

1.14 1.02 1.16 1.23 1.29 1.02 1.05 3.37 1.02 1.13

1.64E-01 8.68E-01 6.64E-01 3.53E-01 2.75E-01 2.24E-01 3.29E-01 2.39E-01 8.74E-01 3.51E-01

MSMEG_2238 MSMEG_2239 MSMEG_2240 MSMEG_2241 MSMEG_2242 MSMEG_2243 MSMEG_2244 MSMEG_2245 MSMEG_2246 MSMEG_2247 MSMEG_2248 MSMEG_2249 MSMEG_2250 MSMEG_2251 MSMEG_2252 MSMEG_2253 MSMEG_2254 MSMEG_2255 MSMEG_2256 MSMEG_2257 MSMEG_2258 MSMEG_2259 MSMEG_2260 MSMEG_2261 MSMEG_2262 MSMEG_2263 MSMEG_2264 MSMEG_2265 MSMEG_2266 MSMEG_2267 MSMEG_2268 MSMEG_2269 MSMEG_2270 MSMEG_2271 MSMEG_2271 MSMEG_2272 MSMEG_2273 MSMEG_2274

aldehyde dehydrogenase (NAD) family protein transcriptional regulator, TetR family protein cytochrome P450 medium chain acyl-CoA synthetase coniferyl aldehyde dehydrogenase isochorismatase family protein Rieske [2Fe-2S] domain protein bile-acid 7-alpha dehydratase conserved hypothetical protein dihydrokaempferol 4-reductase two-component system sensor kinase conserved hypothetical protein hypothetical protein nitrate/nitrite response regulator protein flavin-type hydroxylase hypothetical protein oxalate decarboxylase OxdC, putative Carboxyl transferase domain protein conserved hypothetical protein cytochrome P450-terp conserved hypothetical protein carbon starvation protein A putative transcriptional regulator hypothetical protein hydrogenase-2, small subunit hydrogenase-2, large subunit peptidase M52, hydrogen uptake protein hypothetical protein hypothetical protein tetratricopeptide repeat domain protein conserved hypothetical protein NHL repeat protein hypothetical protein hydrogenase accessory protein HypB hydrogenase accessory protein HypB hydrogenase nickel insertion protein HypA [NiFe] hydrogenase maturation protein HypF hydrogenase assembly chaperone HypC/HupF

hybA hybC

hypB hypB hypA hypF hypC

1.32 0.99 1.02 0.85 1.00 0.90 2.15 1.69 1.38 0.88 1.15 0.66 1.24 1.88 0.53 1.15 1.39 0.97 0.94 1.11 1.30 1.27 1.32 6.08 5.41 5.43 2.27 1.07 2.57 3.35 2.90 2.60 3.65 1.52 1.31 1.88 2.04 1.78

3.12E-03 8.84E-01 7.26E-01 3.37E-01 9.90E-01 3.17E-01 3.51E-01 5.67E-05 1.03E-01 3.87E-02 5.32E-01 2.27E-04 2.10E-01 1.55E-02 1.47E-03 5.89E-02 3.05E-02 6.81E-01 7.11E-01 6.91E-01 9.10E-02 2.41E-01 2.16E-01 6.11E-03 3.37E-03 4.76E-03 1.87E-02 7.63E-02 1.70E-03 3.80E-03 9.19E-03 2.97E-03 3.67E-03 2.12E-03 1.36E-02 4.36E-03 6.06E-03 5.94E-03

1.24 1.10 1.07 0.98 1.16 0.94 1.17 0.90 1.01 1.54 0.92 1.35 1.22 0.90 1.22 1.39 1.33 1.41 1.30 1.12 1.16 1.02 1.72 4.30 4.09 3.68 3.55 0.90 3.88 3.44 3.43 3.61 4.05 2.21 2.76 2.04 2.06 3.05


1.22 1.05 1.00 0.78 0.87 0.94 1.30 0.76 0.88 0.87 0.90 2.08 1.34 0.82 1.12 1.07 2.55 1.03 1.02 1.03 0.21 0.21 1.03 4.12 5.69 6.18 4.39 1.00 6.54 5.20 9.97 16.20 14.90 2.31 1.56 1.83 2.96 2.48


MSMEG_2275 MSMEG_2276 MSMEG_2277 MSMEG_2278 MSMEG_2279 MSMEG_2280 MSMEG_2281

MSMEG_2284

MSMEG_2285 MSMEG_2286 MSMEG_2286 MSMEG_2287 MSMEG_2287 MSMEG_2288 MSMEG_2288 MSMEG_2289 MSMEG_2289 MSMEG_2290 MSMEG_2290 MSMEG_2291 MSMEG_2291 MSMEG_2292 MSMEG_2292 MSMEG_2293 MSMEG_2293 MSMEG_2294 MSMEG_2294 MSMEG_2295 MSMEG_2295 MSMEG_2296 MSMEG_2297 MSMEG_2297

hydrogenase expression/formation protein HypD hydrogenase expression/formation protein HypE DNA ligase I, ATP-dependent membrane-bound oxidoreductase 3-hydroxyacyl-CoA dehydrogenase type-2 pyruvate dehydrogenase This gene is disrupted by an IS1096 element.; conserved hypothetical protein, interruption-C; identified by similarity to GB:BAB49125.1; match to protein family HMM PF01638 This gene is disrupted by an IS1096 element.; conserved hypothetical protein, interruption-N; identified by similarity to OMNI:NTL02MT01721 methyltransferase type 11 aminoglycoside phosphotransferase aminoglycoside phosphotransferase transport protein transport protein conserved hypothetical protein conserved hypothetical protein cytochrome p450 cytochrome p450 transcriptional regulator, TetR family protein transcriptional regulator, TetR family protein short chain dehydrogenase short chain dehydrogenase alkaline phosphatase alkaline phosphatase conserved hypothetical protein conserved hypothetical protein DNA polymerase IV DNA polymerase IV transcriptional regulator, TetR family protein transcriptional regulator, TetR family protein secreted protein glutaredoxin glutaredoxin

hypD hypE dnl1

dinB dinB

1.81 1.95 1.33 1.83 0.60 0.97

1.15E-03 1.64E-03 1.21E-01 4.58E-02 1.52E-02 8.95E-01

1.99 1.71 1.00 0.81 1.12 1.10

4.41E-02 5.19E-03 9.83E-01 3.63E-02 3.44E-01 4.27E-01

5.24 1.95 1.12 0.82 0.98 0.65

8.66E-02 1.13E-01 3.03E-01 2.57E-01 3.25E-01 1.92E-03

1.02

8.65E-01

1.16

3.28E-01

1.03

5.79E-01

3.83 4.43 1.27 1.10 0.28 0.42 1.59 1.40 4.21 3.51 1.38 0.93 0.87 1.07 0.66 0.83 0.58 0.72 1.31 1.07 1.16 0.93 1.42 0.38 0.43


0.61 0.94 0.79 0.96 1.45 0.98 1.19 0.98 0.77 0.87 1.09 0.97 0.79 0.88 1.41 0.95 0.88 1.15 0.92 1.01 0.87 0.99 4.49 1.86 2.34


1.18 0.50 0.70 0.95 1.34 1.12 1.50 1.08 0.17 0.25 0.70 0.98 1.39 1.08 1.23 1.14 1.09 0.95 1.69 1.43 2.01 1.25 1.05 2.46 1.97


MSMEG_2298 protein NrdI; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF07972 MSMEG_2298 protein NrdI; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF07972 MSMEG_2299 ribonucleoside-diphosphate reductase, alpha subunit MSMEG_2299 ribonucleoside-diphosphate reductase, alpha subunit MSMEG_2300 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2300 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2300 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2301 glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_2301 glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_2302 conserved hypothetical protein MSMEG_2303 integral membrane transporter MSMEG_2303 integral membrane transporter MSMEG_2304 hypothetical protein MSMEG_2305 TetR-family protein transcriptional regulator MSMEG_2306 putative acetyltransferase MSMEG_2307 conserved hypothetical protein MSMEG_2307 conserved hypothetical protein MSMEG_2308 geranylgeranyl reductase MSMEG_2309 probable transcriptional regulatory protein MSMEG_2309 probable transcriptional regulatory protein MSMEG_2310 monooxygenase MSMEG_2310 monooxygenase

0.35

4.26E-03

1.76

9.64E-02

3.02

1.29E-01

0.39

6.04E-03

2.59

1.56E-01

1.37

3.07E-01

0.30

1.75E-03

2.81

1.56E-01

1.43

2.84E-01

0.41

3.66E-03

2.19

1.76E-01

8.71

2.93E-01

1.26

1.87E-02

1.57

1.37E-01

0.84

1.07E-01

0.67

1.61E-01

1.09

2.62E-01

1.24

1.83E-01

2.39

2.50E-01

1.03

6.81E-01

1.06

5.36E-01

0.93

8.78E-03

0.86

1.47E-01

0.66

5.98E-02

0.79 1.00 2.26 2.76 2.38 0.88 0.91 0.47 0.67 1.14 0.58 0.65 1.40 1.14

1.49E-02 9.36E-01 8.64E-04 1.01E-03 3.39E-04 4.15E-01 5.18E-01 6.22E-05 1.70E-02 3.11E-02 6.76E-04 1.78E-03 2.13E-03 3.43E-01

1.03 1.93 0.82 0.90 0.78 1.03 0.90 1.46 1.04 0.78 1.16 1.07 0.68 0.76

3.51E-01 2.35E-01 1.96E-01 4.26E-01 8.89E-02 8.21E-01 3.53E-01 3.29E-01 9.06E-01 1.29E-01 1.15E-01 4.82E-01 4.11E-03 3.26E-02

0.99 1.00 0.17 0.23 0.31 1.00 1.15 0.90 1.04 0.67 1.18 0.95 4.05 3.48

9.52E-01 9.63E-01 6.96E-05 9.71E-05 4.47E-04 9.96E-01 1.71E-01 1.46E-01 3.90E-01 8.34E-03 9.78E-02 4.79E-01 7.90E-05 1.68E-04

MSMEG_2311 MSMEG_2311 MSMEG_2312 MSMEG_2313 MSMEG_2313 MSMEG_2314 MSMEG_2314 MSMEG_2315 MSMEG_2315 MSMEG_2316 MSMEG_2316 MSMEG_2316 MSMEG_2317 MSMEG_2317 MSMEG_2318 MSMEG_2318 MSMEG_2319 MSMEG_2319 MSMEG_2320

MSMEG_2320

MSMEG_2321 MSMEG_2321

conserved hypothetical protein conserved hypothetical protein hypothetical protein ribonucleoside-diphosphate reductase, beta subunit ribonucleoside-diphosphate reductase, beta subunit putative esterase family protein putative esterase family protein conserved hypothetical protein conserved hypothetical protein monooxygenase, NtaA/SnaA/SoxA family; this gene contains a frame shift which is not the result of sequencing error monooxygenase, NtaA/SnaA/SoxA family; this gene contains a frame shift which is not the result of sequencing error monooxygenase, NtaA/SnaA/SoxA family; this gene contains a frame shift which is not the result of sequencing error alcohol dehydrogenase, zinc-containing alcohol dehydrogenase, zinc-containing GTP cyclohydrolase II GTP cyclohydrolase II Periplasmic binding protein Periplasmic binding protein cytochrome c oxidase, subunit I; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00115; match to protein family HMM TIGR02891 cytochrome c oxidase, subunit I; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00115; match to protein family HMM TIGR02891 phosphoserine phosphatase phosphoserine phosphatase

0.66 0.74 0.50

1.01E-03 3.47E-03 1.80E-02

0.88 1.04 1.50

2.00E-01 6.55E-01 1.65E-01

4.05 2.76 0.87

4.10E-02 1.62E-01 2.57E-01

0.40

1.09E-03

1.53

4.47E-02

2.01

3.65E-02

0.49 0.66 0.76 1.45 1.11

3.43E-03 6.90E-03 3.95E-02 1.23E-02 2.59E-01

2.20 0.78 0.86 0.86 1.03

1.09E-01 8.14E-02 2.10E-01 3.92E-02 4.98E-01

1.13 3.03 4.21 1.48 1.33

2.94E-01 5.51E-03 7.46E-03 3.86E-02 8.15E-02

0.33

8.67E-05

8.49

1.78E-01

2.10

1.09E-02

0.59

5.09E-03

16.04

1.82E-01

3.25

1.75E-02

0.85 0.64 0.61 0.50 0.64 0.39 0.42

3.35E-01 2.38E-04 2.77E-04 5.69E-06 2.59E-04 5.33E-06 2.37E-05

4.79 1.07 0.97 0.88 0.98 0.90 1.05

2.64E-01 5.47E-01 7.19E-01 1.81E-01 8.45E-01 3.26E-01 5.56E-01

1.24 0.77 1.20 1.66 0.92 2.23 1.40

2.82E-01 7.18E-03 2.10E-01 8.99E-02 5.23E-01 5.76E-02 1.43E-01

ctaD

0.34

3.53E-07

0.82

6.51E-02

4.11

3.43E-04

ctaD serB serB

0.50 0.28 0.29

7.90E-05 5.89E-06 6.81E-06

0.99 1.06 1.00

8.58E-01 2.72E-01 9.27E-01

2.94 8.94 6.17

6.77E-03 2.01E-02 2.30E-02

MSMEG_2322 MSMEG_2322 MSMEG_2323 MSMEG_2324 MSMEG_2325 MSMEG_2325 MSMEG_2326 MSMEG_2326 MSMEG_2327 MSMEG_2327 MSMEG_2328 MSMEG_2328 MSMEG_2329 MSMEG_2329 MSMEG_2330 MSMEG_2330 MSMEG_2331 MSMEG_2331 MSMEG_2332 MSMEG_2332 MSMEG_2333 MSMEG_2334 MSMEG_2335 MSMEG_2336 MSMEG_2336 MSMEG_2337 MSMEG_2337 MSMEG_2340 MSMEG_2341 MSMEG_2342 MSMEG_2343 MSMEG_2344

hypothetical protein hypothetical protein GntR-family protein transcriptional regulator hypothetical protein integral membrane protein integral membrane protein ABC-type molybdenum transport system, ATPase component ABC-type molybdenum transport system, ATPase component nudix hydrolase nudix hydrolase probable enoyl-CoA hydratase probable enoyl-CoA hydratase methyltransferase, UbiE/COQ5 family protein methyltransferase, UbiE/COQ5 family protein SAM-dependent methyltransferase SAM-dependent methyltransferase immunogenic protein MPB64/MPT64 immunogenic protein MPB64/MPT64 amino acid carrier protein amino acid carrier protein conserved hypothetical protein hypothetical protein hexapeptide transferase family protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error isopentenyl-diphosphate delta-isomerase, type 2 fni isopentenyl-diphosphate delta-isomerase, type 2 fni hypothetical protein conserved hypothetical protein putative glycosyltransferase methylesterase dehydrogenase

0.91 1.04 1.33 0.99 1.24 0.95

1.67E-01 5.53E-01 2.82E-01 9.25E-01 6.00E-02 4.78E-01

0.76 0.86 1.10 0.97 1.25 0.92

2.60E-02 1.39E-01 3.99E-01 8.15E-01 1.54E-01 1.86E-01

0.89 1.12 1.29 1.20 1.26 1.03

1.32E-01 3.38E-01 1.60E-01 3.11E-01 1.19E-01 8.98E-01

0.51

9.04E-04

0.77

8.99E-02

1.91

1.67E-01

0.69 0.52 0.56 0.57 0.67 0.61 0.74 0.36 0.49 1.23 1.04 0.68 0.74 0.52 0.75 0.48


0.97 1.09 0.97 1.12 0.93 0.81 0.87 0.72 1.07 0.93 0.84 1.38 1.23 0.80 1.17 1.15


1.11 1.55 1.14 1.18 1.03 0.65 0.74 0.75 1.58 0.55 0.68 0.16 0.24 1.46 1.03 0.86


1.79

8.93E-02

1.27

9.81E-03

0.72

1.26E-02

1.57 1.88 1.57 1.05 1.02 1.08 1.45 1.59

1.85E-01 1.04E-01 1.52E-01 4.81E-01 9.09E-01 3.72E-01 5.24E-01 3.30E-01

0.96 1.99 1.70 1.02 1.16 1.01 1.92 2.62

6.62E-01 2.92E-02 4.85E-02 9.23E-01 1.96E-01 8.44E-01 1.67E-02 1.45E-02

0.94 0.40 0.52 0.98 1.19 1.08 0.63 0.53

1.69E-01 4.38E-04 6.05E-03 3.99E-01 2.13E-01 3.25E-01 1.21E-01 5.86E-02

MSMEG_2345 lycopene cyclase; this gene contains a frame shift which is not the result of sequencing error MSMEG_2346 phytoene synthase MSMEG_2347 phytoene dehydrogenase MSMEG_2348 glycosyl transferase, group 1 family protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00534 MSMEG_2348 glycosyl transferase, group 1 family protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00534 MSMEG_2349 glycosyl hydrolase, family protein 57 MSMEG_2350 conserved hypothetical protein MSMEG_2351 electron transfer flavoprotein, beta subunit MSMEG_2352 electron transfer flavoprotein, alpha subunit MSMEG_2353 secreted protein MSMEG_2354 oxidoreductase MSMEG_2355 conserved hypothetical protein MSMEG_2356 acyltransferase MSMEG_2357 cysteine desulfurase MSMEG_2358 tRNA (5-methylaminomethyl-2-thiouridylate)methyltransferase MSMEG_2359 methionine synthase, vitamin-B12 independent MSMEG_2360 4-coumarate:CoA ligase MSMEG_2361 phosphoribosylglycinamide formyltransferase MSMEG_2362 DNA ligase, NAD-dependent MSMEG_2363 amino acid-binding ACT MSMEG_2364 glutamyl-tRNA(Gln) amidotransferase, C subunit MSMEG_2365 glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_2366 6-phosphofructokinase 1; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00365; match to protein family HMM TIGR02483 MSMEG_2367 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

etfB etfA

trmU

ligA gatC

1.32 1.88 1.63

4.02E-01 3.19E-01 9.84E-02

2.80 2.93 1.51

3.81E-02 1.92E-02 8.83E-02

0.58 0.46 0.50

5.00E-02 3.08E-03 4.75E-04

0.38

2.77E-05

0.80

5.24E-02

1.53

1.33E-02

0.51 0.44 0.71 0.62 0.56 2.46 1.85 0.69 1.04 1.44

1.59E-03 6.19E-05 6.11E-04 2.75E-04 7.13E-04 5.91E-04 1.62E-02 9.81E-03 5.09E-01 4.52E-02

1.16 1.01 0.95 0.94 0.73 0.87 0.97 1.24 4.46 0.82

3.72E-01 8.87E-01 6.84E-01 3.06E-01 5.67E-03 6.48E-02 7.39E-01 2.82E-01 3.90E-01 4.19E-02

1.00 1.61 0.96 1.49 0.91 1.11 1.25 1.58 1.27 2.38

9.80E-01 1.72E-01 5.15E-01 3.41E-02 5.71E-01 5.36E-01 3.16E-01 3.65E-01 2.32E-01 4.03E-02

1.35 0.74 1.03 0.93 0.93 0.53 0.46 0.33

4.49E-02 4.20E-03 5.74E-02 4.40E-02 5.79E-01 2.63E-05 1.10E-04 1.56E-05

0.76 1.02 0.91 1.00 0.77 1.02 0.91 0.94

4.20E-02 8.92E-01 1.85E-01 9.52E-01 7.99E-03 8.85E-01 1.76E-01 6.34E-01

1.96 2.03 1.46 1.17 1.18 1.08 1.57 1.33

7.26E-02 9.72E-03 3.75E-02 3.65E-01 3.75E-01 5.70E-01 1.49E-01 2.53E-01

0.97

7.23E-01

0.85

1.06E-01

1.29

1.86E-03

0.71

7.50E-04

0.99

8.53E-01

2.05

6.19E-03

MSMEG_2368 transcriptional regulator, TetR family protein domain protein, putative MSMEG_2369 LppZ protein MSMEG_2370 DoxX subfamily protein, putative MSMEG_2371 Low molecular weight protein antigen 6 MSMEG_2372 acetolactate synthase, large subunit, biosynthetic type MSMEG_2373 acetolactate synthase, small subunit MSMEG_2374 ketol-acid reductoisomerase MSMEG_2375 NAD(P)H:quinone oxidoreductase, type IV MSMEG_2376 conserved hypothetical protein MSMEG_2377 P49 protein MSMEG_2378 D-3-phosphoglycerate dehydrogenase MSMEG_2379 3-isopropylmalate dehydrogenase MSMEG_2380 sugar transporter family protein MSMEG_2381 conserved hypothetical protein MSMEG_2382 5-carboxymethyl-2-hydroxymuconate deltaisomerase MSMEG_2383 glutamyl-tRNA synthetase MSMEG_2386 transcriptional regulator, IclR family protein MSMEG_2387 3-isopropylmalate dehydratase, large subunit MSMEG_2388 3-isopropylmalate dehydratase, small subunit MSMEG_2389 DNA-binding protein HU MSMEG_2390 hydrolase, NUDIX family protein MSMEG_2391 polyphosphate kinase MSMEG_2392 conserved hypothetical protein MSMEG_2393 NAD-dependent glycerol-3-phosphate dehydrogenase MSMEG_2394 putative cystathionine gamma-synthase MSMEG_2395 D-alanine--D-alanine ligase MSMEG_2396 conserved hypothetical protein MSMEG_2397 transcriptional regulatory protein, AsnC family protein MSMEG_2398 thiamine-monophosphate kinase MSMEG_2399 uracil-DNA glycosylase MSMEG_2400 ribosomal protein L28 MSMEG_2401 hypothetical protein MSMEG_2402 dihydroxyacetone kinase

ilvB ilvN ilvC wrbA serA leuB

gltX leuC leuD hup ppk gpsA

thiL ung rpmB

1.49 1.10 1.52 0.61

1.82E-02 6.87E-03 4.68E-03 6.99E-04

0.82 0.86 0.84 0.76

1.37E-02 8.02E-02 1.45E-01 5.65E-02

0.76 1.02 1.49 2.35

1.96E-03 8.52E-01 2.72E-01 2.41E-03

0.52 0.77 0.46 1.02 0.92 1.08 0.43 0.45 0.60 0.56

1.36E-03 2.06E-02 3.51E-04 8.68E-01 8.48E-01 6.32E-01 3.62E-05 6.38E-05 4.78E-04 4.82E-03

0.96 0.76 0.96 1.36 1.76 1.02 1.20 1.14 0.95 1.07

5.89E-01 5.80E-02 5.39E-01 1.70E-01 7.89E-02 9.51E-01 7.37E-02 1.38E-01 8.49E-01 4.00E-01

1.30 0.96 1.67 0.51 0.64 0.95 1.41 1.60 1.49 1.53

3.80E-03 5.83E-01 1.27E-01 1.87E-02 9.60E-02 4.03E-01 1.07E-01 5.98E-02 2.98E-01 2.02E-02

0.38 0.37 0.60 0.81 0.60 2.29 0.55 0.79 0.50

2.44E-04 3.95E-06 5.01E-03 8.93E-03 2.15E-05 1.45E-04 2.44E-03 9.90E-02 5.50E-04

0.97 1.11 1.03 0.72 0.83 0.88 1.81 1.09 1.07

6.44E-01 4.91E-02 7.85E-01 5.11E-03 1.68E-02 1.28E-01 2.26E-01 5.19E-01 5.94E-01

2.39 1.48 1.00 1.03 1.01 0.54 1.72 1.43 1.30

2.21E-01 6.36E-02 8.46E-01 7.60E-01 9.57E-01 3.51E-02 6.18E-03 2.02E-02 9.29E-02

0.36 0.41 0.49 1.40

3.51E-05 9.44E-05 3.30E-04 4.64E-02

1.38 1.12 0.93 1.03

2.04E-01 5.78E-01 1.51E-01 8.54E-01

3.13 1.98 1.73 1.61

2.59E-02 3.38E-03 2.02E-01 4.13E-03

0.62 0.80 0.54 1.07 0.94 0.80

1.44E-04 1.60E-01 6.35E-05 2.02E-01 5.00E-01 4.58E-02

0.87 0.81 1.05 0.65 1.04 1.20

1.67E-01 1.68E-01 6.69E-01 1.76E-02 7.48E-01 1.13E-01

1.53 1.80 1.46 0.56 1.27 2.64

1.61E-01 2.02E-01 1.24E-01 1.54E-03 2.84E-01 2.55E-01


ATP-dependent DNA helicase RecG extracellular deoxyribonuclease MarR-family protein transcriptional regulator transcriptional regulator, TetR family protein, putative morphine 6-dehydrogenase 2,5-diketo-D-gluconic acid reductase A alpha/beta hydrolase fold family protein putative serine-threonine protein kinase conserved integral membrane protein pyruvate carboxylase putative methyltransferase pantetheine-phosphate adenylyltransferase hemerythrin HHE cation binding region conserved hypothetical protein conserved hypothetical protein ribonuclease III formamidopyrimidine-DNA glycosylase hypothetical protein conserved hypothetical protein acylphosphatase chromosome segregation protein SMC signal recognition particle-docking protein FtsY ammonium transporter nitrogen regulatory protein P-II protein-P-II uridylyltransferase DNA-binding protein aldo/keto reductase signal recognition particle protein amidohydrolase 3 D-alanyl-D-alanine carboxypeptidase D-alanyl-D-alanine carboxypeptidase conserved hypothetical protein 30S ribosomal protein S16 conserved hypothetical protein 16S rRNA processing protein RimM tRNA (guanine-N1)-methyltransferase LppW protein

recG

pyc coaD

rnc mutM

smc ftsY amt glnD ffh

rimM trmD

0.84 0.54 1.69

1.37E-01 1.11E-03 7.11E-03

0.96 1.13 0.98

5.88E-01 2.14E-01 5.54E-01

1.03 0.97 0.78

5.99E-01 8.31E-01 2.31E-01

1.11 0.98 0.95 0.72 0.71 0.64 0.92 0.33 0.86 1.41 1.44 0.86 1.17 0.43 1.73 0.72 2.07 0.85 0.56 0.12 0.12 0.23 2.77 1.97 0.84 0.51 0.91 0.50 0.57 0.61 0.57 0.18 0.36 0.72


1.10 0.84 0.93 0.99 0.77 0.82 0.72 1.03 1.16 2.42 0.90 0.84 0.97 0.97 0.88 1.16 0.83 1.19 1.10 3.66 2.47 1.51 0.79 1.11 0.58 1.02 0.84 0.97 0.85 1.02 0.54 0.79 1.37 1.12


1.04 0.94 1.33 0.67 0.96 1.73 2.35 2.11 1.20 0.23 1.28 1.44 1.65 3.32 0.59 1.06 0.80 2.69 1.17 0.41 0.42 0.95 0.98 1.12 1.18 1.62 1.20 0.82 1.10 1.49 0.99 1.57 1.68 1.25



ribosomal protein L19 signal peptidase I ribonuclease HII conserved hypothetical protein dienelactone hydrolase family protein conserved hypothetical protein conserved hypothetical protein regulatory protein hypothetical protein methylmalonate-semialdehyde dehydrogenase adenosylmethionine--8-amino-7-oxononanoate transaminase HAD-superfamily protein hydrolase, subfamily protein IIA hypothetical protein transcriptional regulator, GntR family protein translation initiation inhibitor carbon monoxide dehydrogenase subunit G (CoxG) superfamily protein 5,10-methylenetetrahydromethanopterin hypothetical protein hypothetical protein transporter ATPase transporter permease 1 transporter permease 2, putative carbon-monoxide dehydrogenase nicotine dehydrogenase chain A [2Fe-2S] binding domain protein adenine deaminase glutaryl-CoA dehydrogenase transketolase, central region L-carnitine dehydratase/bile acid-inducible protein F AMP-dependent synthetase and ligase acyl-CoA thioesterase pyruvate dehydrogenase alpha subunit AsnC-family protein transcriptional regulator

rplS lepB

mmsA

0.77 0.47 1.11 1.20 1.56 1.91 1.96 2.03 2.01 2.27

1.71E-03 8.78E-05 7.89E-02 1.86E-02 1.33E-03 1.01E-01 5.28E-04 2.82E-03 2.34E-02 2.07E-03

0.78 0.90 0.88 0.94 0.79 0.89 0.85 0.79 0.72 0.86

1.26E-02 4.50E-01 1.16E-01 5.02E-01 2.13E-02 3.68E-01 1.52E-01 2.35E-01 5.43E-02 8.91E-02

0.90 1.51 2.67 1.48 0.73 1.30 0.81 1.76 3.27 0.97

5.04E-01 4.03E-02 1.01E-03 9.59E-02 1.65E-02 1.39E-01 1.79E-01 7.45E-02 3.47E-01 7.38E-01

1.59

1.95E-03

1.10

5.11E-01

1.25

8.61E-02

0.93 0.74 1.18 0.97

4.83E-01 1.51E-02 3.34E-01 6.62E-01

1.07 0.80 0.87 0.90

3.30E-01 2.30E-01 2.91E-01 5.30E-01

3.45 1.26 1.31 1.49

2.72E-01 4.14E-02 3.60E-02 8.54E-02

1.05 2.28 1.74 1.56 1.66 2.02 1.11 0.96 1.38 1.14 1.15 0.99 1.32

4.10E-01 1.01E-03 1.04E-02 5.65E-03 1.61E-03 2.53E-01 3.96E-01 5.11E-01 7.76E-02 2.02E-01 6.72E-01 8.12E-01 1.62E-01

0.89 0.79 0.79 0.79 0.72 0.76 0.82 0.92 0.87 1.02 0.97 0.94 0.71

3.33E-01 2.26E-01 2.82E-01 1.10E-01 5.99E-03 4.33E-03 1.12E-01 3.82E-01 4.99E-01 7.75E-01 7.93E-01 4.31E-01 1.47E-02

1.22 1.01 1.08 0.91 1.02 1.13 1.52 1.68 1.93 1.56 1.20 2.25 1.40

4.41E-01 9.08E-01 4.91E-01 5.50E-01 8.21E-01 4.07E-01 4.59E-02 9.61E-03 1.04E-02 4.43E-02 3.40E-02 2.91E-02 1.91E-01

0.43 0.51 0.44 3.27 0.95

2.25E-05 9.33E-05 1.35E-02 4.16E-03 7.08E-01

1.31 0.94 1.16 0.91 0.81

3.46E-02 5.00E-01 4.94E-01 6.64E-01 1.84E-01

1.39 1.10 1.20 1.33 1.94

1.92E-01 3.95E-01 1.30E-01 1.89E-01 2.49E-01

MSMEG_2473 sugar transporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_2473 sugar transporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_2474 probable cutinase Cut3 MSMEG_2475 putative oxidoreductase YdbC MSMEG_2476 MarR family protein transcriptional regulatory protein MSMEG_2477 cyclopentanol dehydrogenase MSMEG_2478 fumarylacetoacetate hydrolase family protein MSMEG_2479 hypothetical protein MSMEG_2480 transcriptional regulator, GntR family protein, putative MSMEG_2481 conserved hypothetical protein MSMEG_2482 hypothetical protein MSMEG_2483 transcriptional regulator, IclR family protein MSMEG_2484 conserved hypothetical protein MSMEG_2485 monooxygenase, FAD-binding MSMEG_2486 major facilitator superfamily protein MSMEG_2487 4-aminobutyrate aminotransferase MSMEG_2488 [NADP+] succinate-semialdehyde dehydrogenase MSMEG_2489 transcriptional regulator, GntR family protein, putative MSMEG_2490 decarboxylase MSMEG_2491 acetylornithine deacetylase MSMEG_2492 D-lactate dehydrogenase MSMEG_2493 aminotransferase, class I and II family protein MSMEG_2494 Xaa-Pro aminopeptidase MSMEG_2495 decarboxylase MSMEG_2496 NAD-binding protein MSMEG_2497 amidase family protein MSMEG_2498 conserved hypothetical protein MSMEG_2499 ABC transporter, membrane spanning protein, putative MSMEG_2500 conserved hypothetical protein MSMEG_2501 ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit MSMEG_2502 transporter ATPase

1.24

2.24E-01

1.22

2.99E-02

1.33

1.10E-01

0.98 1.01 0.49

9.24E-01 9.31E-01 2.17E-02

0.95 1.06 1.01

8.56E-02 6.64E-01 9.33E-01

1.02 0.95 0.99

7.13E-01 2.47E-01 9.14E-01

0.89 0.84 1.27 1.18

2.87E-01 2.16E-01 1.66E-02 6.47E-01

0.84 1.01 0.93 1.05

1.12E-01 9.61E-01 4.35E-01 6.11E-01

1.10 1.35 1.68 0.85

4.07E-01 4.97E-01 2.21E-02 2.58E-01

0.84 0.73 1.42 1.35 1.26 1.31 2.77 1.94 0.87

1.46E-01 7.36E-03 4.35E-02 7.54E-02 5.35E-02 4.35E-01 3.18E-02 1.85E-02 1.68E-01

1.00 1.03 0.98 1.07 0.88 0.96 0.74 1.01 0.69

9.90E-01 7.27E-01 6.20E-01 5.05E-01 6.07E-02 4.87E-01 1.50E-01 9.33E-01 1.32E-02

0.80 0.82 0.91 0.89 2.02 1.24 1.32 0.95 1.33

5.52E-02 1.36E-01 3.59E-01 2.02E-01 2.31E-02 1.38E-01 3.12E-01 1.65E-01 2.78E-01

1.31 1.27 1.23 0.85 0.94 0.98 1.20 0.89 1.06 0.71

1.74E-02 2.11E-02 2.52E-01 3.17E-02 6.35E-01 8.47E-01 8.37E-02 1.83E-01 8.97E-01 1.11E-03

0.90 0.84 1.03 1.20 1.16 1.27 1.11 1.05 1.40 0.94

3.18E-01 1.30E-01 5.75E-01 8.78E-02 2.78E-01 8.88E-02 3.93E-01 3.03E-01 4.96E-01 5.11E-01

1.11 1.46 1.25 2.21 1.17 1.08 1.37 1.34 1.40 0.95

4.22E-01 2.96E-02 1.19E-01 2.00E-01 5.58E-01 7.46E-01 3.42E-01 3.42E-01 5.72E-01 7.76E-01

1.06 0.39

4.31E-01 2.67E-04

1.06 0.79

9.18E-02 3.15E-01

0.85 1.26

3.99E-01 1.85E-01

1.31 0.95

1.47E-02 2.61E-01

0.95 0.89

6.87E-01 4.77E-02

0.95 0.74

6.98E-01 1.08E-01

MSMEG_2503 MSMEG_2504 MSMEG_2505 MSMEG_2506 MSMEG_2507 MSMEG_2508 MSMEG_2509 MSMEG_2510

MSMEG_2510


hypothetical protein 3-isopropylmalate dehydratase small subunit 3-isopropylmalate dehydratase large subunit carboxyvinyl-carboxyphosphonate phosphorylmutase IclR-family protein transcriptional regulator conserved hypothetical protein Mg-chelatase subunits D/I family protein, ComM subfamily protein smf family protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02481 smf family protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02481 siderophore utilization protein lactate 2-monooxygenase hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error xerC tyrosine recombinase XerC putative oxidoreductase hydrolase, alpha/beta fold family protein, putative peptidase M23B rpsB ribosomal protein S2 tsf translation elongation factor Ts amidase efflux ABC transporter, permease protein efflux ABC transporter, permease protein, ABC transporter, ATP-binding protein amino acid permease superfamily protein copper methylamine oxidase

0.94 1.07 0.97

1.36E-01 4.39E-01 8.05E-01

0.96 0.82 1.06

3.86E-01 8.23E-02 2.89E-01

0.80 0.78 0.87

2.30E-01 7.44E-02 3.73E-01

1.34 2.02 1.11

1.41E-01 5.44E-03 2.57E-01

0.99 0.94 1.15

9.29E-01 6.68E-01 2.24E-01

0.65 0.79 1.07

4.70E-02 1.25E-01 3.07E-01

1.30

2.15E-01

1.08

5.18E-01

0.91

4.09E-01

1.29

1.57E-01

1.93

1.87E-01

1.97

2.94E-01

1.03 0.75 0.48 13.27

7.30E-01 2.43E-02 5.23E-05 5.19E-02

1.19 0.80 1.14 0.25

2.74E-01 5.29E-02 2.58E-01 1.27E-02

0.95 0.76 1.20 0.69

2.99E-01 2.87E-01 1.41E-01 2.31E-01

2.27

7.75E-02

0.85

2.15E-01

1.44

3.90E-01

1.60 1.36 0.79 0.74 1.45 0.43 0.29 0.54 1.13 0.27 0.10 0.32 0.15

3.21E-01 5.38E-01 6.22E-02 1.47E-01 2.61E-02 5.65E-06 9.64E-08 1.49E-02 6.22E-01 1.88E-03 9.02E-06 1.86E-02 5.03E-05

1.03 0.97 0.78 0.91 1.19 1.10 1.09 0.98 1.47 0.85 1.12 5.21 3.60

8.64E-01 7.09E-01 3.88E-02 1.46E-01 1.40E-01 3.07E-01 2.71E-01 8.97E-01 2.53E-02 2.92E-01 5.99E-01 2.94E-01 3.41E-01

1.01 1.80 1.47 1.53 1.38 1.44 1.73 3.48 0.30 0.99 0.72 0.75 0.65

9.22E-01 4.52E-02 2.68E-01 7.95E-02 1.57E-01 2.80E-02 4.00E-03 1.65E-01 4.51E-03 9.76E-01 1.29E-01 2.29E-01 1.08E-01


hypothetical protein glycerate kinase glyoxylate reductase 4-carboxymuconolactone decarboxylase domain protein GntR family protein transcriptional regulator dehydroquinase dehydratase, type II hypothetical protein putative carboxylesterase protein dehydrogenase/reductase SDR family protein member 10 3-oxoacyl-[acyl-carrier-protein] reductase transporter protein MarR-family protein transcriptional regulator thiopurine S-methyltransferase (tpmt) superfamily protein uridylate kinase ribosome recycling factor integral membrane protein DUF6 phosphatidate cytidylyltransferase transcriptional regulator, LysR family protein radical SAM enzyme, Cfr family protein transcriptional Regulator, GntR family protein transcriptional regulator 3-oxoacyl-[acyl-carrier-protein] reductase major facilitator superfamily protein glyoxylate reductase hypothetical protein aldehyde dehydrogenase (NAD) family protein transcriptional regulator, TetR family protein phosphotransferase enzyme family protein hypothetical protein beta-glucosidase transcriptional regulator, TetR family protein NikQ protein conserved domain protein conserved hypothetical protein gluconolactonase

pcaC aroQ

pyrH frr cdsA

2.03 0.82 0.63

1.43E-02 1.32E-02 8.25E-05

1.41 0.82 0.98

4.14E-01 5.69E-02 6.81E-01

1.05 0.94 1.06

7.79E-01 6.74E-01 6.56E-01

0.64 0.76 1.23 0.98 0.90

6.08E-05 2.49E-02 6.26E-03 8.60E-01 1.39E-01

1.07 1.33 0.78 0.95 1.01

3.03E-01 2.79E-01 2.07E-02 5.23E-01 9.52E-01

1.29 0.96 0.47 0.78 0.65

7.97E-02 5.28E-01 2.09E-04 2.25E-01 3.12E-02

0.68 0.93 0.78 0.54

9.96E-04 2.94E-01 3.80E-02 1.69E-03

0.97 0.91 0.93 1.03

6.05E-01 1.46E-01 2.52E-01 6.23E-01

0.70 0.52 0.66 1.23

8.52E-02 4.80E-02 5.72E-02 2.64E-01

1.66 0.68 0.68 0.76 0.54 0.99 1.09 0.58 1.66 1.20 1.48 1.46 1.05 0.93 1.30 0.60 0.96 1.61 0.98 2.30 1.22 1.20 1.06


1.01 0.85 0.91 1.86 0.96 0.86 0.80 1.08 1.13 0.96 0.98 0.99 0.93 0.85 0.91 1.25 1.17 0.83 1.28 1.20 1.07 1.38 1.14


0.46 1.31 1.23 1.16 1.94 0.95 1.28 1.09 1.29 0.87 1.10 1.33 1.01 1.03 1.08 1.03 1.08 1.27 1.10 1.67 0.97 1.60 1.17


MSMEG_2562 conserved hypothetical protein MSMEG_2563 cytochrome P450 superfamily protein MSMEG_2564 oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_2565 4-hydroxy-2-oxovalerate aldolase MSMEG_2566 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase MSMEG_2567 probable monooxygenase MSMEG_2568 LipW protein MSMEG_2569 oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_2570 xanthine/uracil permease MSMEG_2571 cupin 2, conserved barrel MSMEG_2572 conserved hypothetical protein MSMEG_2573 conserved hypothetical protein MSMEG_2574 conserved hypothetical protein MSMEG_2575 conserved hypothetical protein MSMEG_2576 deoxyribodipyrimidine photo-lyase MSMEG_2577 hypothetical protein MSMEG_2578 1-deoxy-D-xylulose 5-phosphate reductoisomerase MSMEG_2579 zinc metalloprotease MSMEG_2580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase MSMEG_2581 acetyltransferase MSMEG_2582 conserved hypothetical protein MSMEG_2583 putative transcriptional regulator MSMEG_2584 penicillin-binding protein, putative MSMEG_2585 conserved hypothetical protein MSMEG_2586 conserved hypothetical protein, putative MSMEG_2587 methionine aminopeptidase, type I MSMEG_2588 cobyric acid synthase CobQ MSMEG_2589 conserved hypothetical protein MSMEG_2590 AraC-family protein transcriptional regulator MSMEG_2591 hypothetical protein MSMEG_2592 conserved hypothetical protein MSMEG_2593 gnat-family protein acetyltransferase MSMEG_2594 asparagine synthase (glutamine-hydrolyzing)

1.21 1.67

4.95E-01 6.35E-03

1.40 0.85

1.82E-01 1.77E-01

1.35 1.40

3.80E-01 1.66E-01

1.01 1.21

8.86E-01 6.05E-01

1.14 1.02

2.36E-01 7.57E-01

1.13 0.82

1.97E-01 1.89E-01

0.95 1.18 1.12

2.82E-01 2.92E-01 1.59E-01

0.88 1.04 0.95

9.14E-02 7.42E-01 4.80E-01

0.98 1.26 1.29

8.78E-01 5.25E-01 4.39E-01

0.55 0.63 0.91 1.29 1.30 1.17 0.69 1.49 1.02

2.91E-02 1.58E-01 1.73E-01 1.98E-02 1.95E-01 2.21E-01 4.24E-03 2.84E-02 6.69E-01

1.15 0.85 0.98 0.98 1.16 0.97 0.69 1.15 0.98

5.70E-01 1.89E-01 6.08E-01 7.41E-01 9.10E-03 8.36E-01 3.99E-02 3.28E-01 8.06E-01

1.09 1.18 0.96 1.02 0.94 1.03 1.55 1.39 1.47

3.96E-01 5.73E-01 8.40E-01 8.28E-01 3.81E-01 7.84E-01 2.57E-02 1.78E-01 1.81E-01

dxr

1.22 0.87

1.74E-02 6.35E-03

0.84 0.81

3.78E-02 2.49E-02

2.09 1.87

7.29E-04 9.19E-02

ispG

1.28 1.75 2.13 1.31 1.16 0.88 0.78 1.31 0.62 0.95 2.54 2.80 3.28 1.48 2.07


0.79 0.74 0.69 0.97 1.14 0.82 1.13 0.76 0.87 1.24 1.03 0.80 0.77 1.19 0.89


1.64 0.96 1.27 1.13 3.47 1.82 0.79 0.94 2.27 0.97 1.66 1.60 0.20 1.08 0.68


map cobQ

asnB


gamma-glutamylisopropylamide synthetase peptidase C26 aldehyde dehydrogenase short chain dehydrogenase GntR-family protein transcriptional regulator regulatory protein protocatechuate 3,4-dioxygenase, beta subunit protocatechuate 3,4-dioxygenase, alpha subunit 3-carboxy-cis,cis-muconate cycloisomerase 4-carboxymuconolactone decarboxylase transcriptional regulator, GntR family protein ArsR-family protein transcriptional regulator cobalamin biosynthesis protein CbiM cobalt transport protein CbiM cobalt ABC transporter, permease protein CbiQ cobalt transport protein ATP-binding subunit pyridine nucleotide-disulphide oxidoreductase family protein conserved hypothetical protein malate:quinone-oxidoreductase ElaA protein chelatase cob(I)alamin adenosyltransferase cobyrinic Acid a,c-diamide synthase uroporphyrin-III C-methyltransferase efflux protein hypothetical protein prolyl-tRNA synthetase conserved hypothetical alanine rich protein Tat (twin-arginine translocation) pathway signal sequence domain protein conserved hypothetical protein transcription termination factor NusA conserved hypothetical protein hypothetical protein translation initiation factor IF-2 ribosome-binding factor A DHH family protein

pcaH pcaG pcaB pcaC cbiM cbiQ

mqo cobO cobB cobA proS

nusA infB rbfA

2.49 1.96 1.48 1.93 1.29 1.37 6.68 6.22 4.07 3.92 1.00 1.33 0.70 0.86 0.89 0.86


1.06 0.91 0.83 0.77 0.80 0.94 0.69 0.75 0.79 0.75 0.97 0.89 1.50 1.68 1.87 1.59


2.12 3.44 2.52 2.34 2.96 1.70 0.10 0.19 0.20 0.42 1.19 0.96 0.91 0.75 1.35 1.55


1.12 0.79 0.77 0.43 0.43 0.51 0.41 0.47 1.74 1.01 0.60 0.78

1.52E-01 3.68E-03 1.58E-03 1.08E-06 3.74E-06 4.41E-04 4.96E-06 2.27E-04 8.85E-03 8.66E-01 1.21E-04 2.96E-02

0.91 0.96 0.92 1.01 1.06 1.10 1.19 1.00 0.57 0.75 0.95 0.94

2.74E-01 3.33E-01 1.32E-02 8.72E-01 4.78E-01 4.52E-01 7.98E-03 9.00E-01 4.22E-03 2.78E-02 4.80E-01 7.47E-01

1.67 2.84 3.67 6.50 7.27 7.26 12.77 2.32 1.15 0.95 1.35 0.92

9.32E-03 5.74E-03 1.73E-04 4.22E-04 5.78E-04 1.40E-02 3.05E-02 1.47E-01 2.57E-01 6.13E-01 1.36E-01 2.92E-01

0.64 1.20 1.10 1.53 1.55 1.15 0.83 0.74

2.88E-02 1.50E-02 6.87E-02 1.30E-03 1.49E-01 1.39E-02 1.00E-02 7.35E-03

1.00 0.99 0.94 0.80 1.05 0.67 0.67 0.84

9.72E-01 9.27E-01 2.37E-01 2.83E-02 7.10E-01 1.52E-03 2.31E-03 2.29E-01

1.23 1.74 2.02 0.55 1.40 1.23 1.51 2.23

8.13E-02 1.21E-04 1.23E-02 1.51E-02 1.55E-01 6.30E-03 2.06E-02 1.59E-02


MATE efflux family protein SAM-dependent methyltransferase ABC transporter ATP-binding protein conserved hypothetical protein ABC transporter permease protein regulatory protein, LacI oxidoreductase, Gfo/Idh/MocA family protein conserved hypothetical protein integral membrane protein 3-dehydroshikimate dehydratase enoyl-CoA hydratase conserved hypothetical protein conserved hypothetical protein putative hydrolase conserved hypothetical protein metallophosphoesterase Sfp-type phosphopantetheinyl transferase tRNA pseudouridine synthase B acyl-CoA dehydrogenase alkanesulfonate monooxygenase family protein iron repressor protein riboflavin biosynthesis protein RibF ribosomal protein S15 LppU protein guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase peptidase, M16 family protein beta-lactamase alanine dehydrogenase transcriptional regulator, AsnC family protein domain of unknown function (306) family protein hypothetical protein conserved hypothetical protein dihydrodipicolinate reductase conserved hypothetical protein multimeric flavodoxin WrbA HpcH/HpaI aldolase/citrate lyase family protein, putative

truB

ribF rpsO gpsI ald

dapB

0.83 2.22 3.54 2.97 4.11 0.93 1.14 1.41 0.42 1.23 0.42 2.11 1.25 0.91 0.98 0.53 0.46 0.37 0.34 0.42 1.07 0.70 0.94 0.47


0.94 0.72 0.72 0.73 0.72 1.16 1.04 1.28 0.81 0.90 0.91 0.96 0.75 0.74 1.18 1.16 0.83 1.20 1.96 3.74 0.92 1.06 0.79 0.94


1.77 1.21 0.76 0.13 0.42 1.71 0.95 1.31 1.05 1.11 1.48 1.29 0.91 2.41 0.41 1.80 2.63 3.01 14.22 10.56 1.11 1.30 0.48 1.03


0.86 0.18 0.30 3.97 1.20 0.85 1.50 3.21 0.67 0.39 0.46

9.61E-03 2.05E-07 7.95E-05 1.88E-02 2.07E-01 6.84E-03 4.60E-02 1.92E-01 3.52E-04 4.18E-03 8.55E-05

0.93 1.13 0.92 0.79 0.72 1.11 1.02 0.78 1.12 1.02 1.14

5.35E-01 2.02E-01 7.34E-01 9.60E-02 1.94E-02 2.27E-01 7.23E-01 1.58E-01 2.05E-01 8.64E-01 1.39E-01

1.17 2.46 1.26 9.49 1.97 1.19 1.12 1.87 1.09 7.17 2.19

1.89E-01 1.03E-02 2.44E-01 1.88E-01 1.35E-01 1.57E-02 1.86E-01 2.88E-01 4.72E-01 3.08E-01 2.79E-02

0.64

4.37E-05

1.05

4.48E-01

1.65

3.11E-03

MSMEG_2668 MSMEG_2669 MSMEG_2670 MSMEG_2671 MSMEG_2672 MSMEG_2673

MSMEG_2674

MSMEG_2675 MSMEG_2676 MSMEG_2676 MSMEG_2677 MSMEG_2678 MSMEG_2679 MSMEG_2680 MSMEG_2681 MSMEG_2682 MSMEG_2683 MSMEG_2684 MSMEG_2685 MSMEG_2686 MSMEG_2687 MSMEG_2688 MSMEG_2689 MSMEG_2690 MSMEG_2691 MSMEG_2692 MSMEG_2693 MSMEG_2694 MSMEG_2695 MSMEG_2696

conserved hypothetical protein hydrolase thymidylate synthase dihydrofolate reductase acyl-CoA synthase similar at the nucleotide level to IS1137 in the IS Finder database. This gene is disrupted by an IS element.; IS1137, transposase orfB, interruptionC similar at the nucleotide level to IS1137 in the IS Finder database. This gene is disrupted by an IS element.; IS1137, transposase orfB, interruptionN ISMsm8, transposase IS1137, transposase orfA IS1137, transposase orfA conserved large membrane protein hypothetical protein conserved hypothetical protein amino acid transporter proline imino-peptidase transcriptional regulator thymidylate synthase, flavin-dependent dihydrodipicolinate synthase metallo-beta-lactamase superfamily protein conserved hypothetical protein carveol dehydrogenase antibiotic biosynthesis monooxygenase domain protein hypothetical protein DNA translocase FtsK acetyltransferase, gnat family protein CDP-diacylglycerol--glycerol-3-phosphate 3phosphatidyltransferase competence-damaged protein transcriptional regulator, XRE family protein 35 kDa protein putative conserved membrane alanine rich protein

thyA folA

thyX dapA

pgsA

0.70 1.08 0.97 0.55 1.04

2.48E-03 2.34E-01 2.86E-01 3.85E-04 4.32E-01

0.94 1.06 1.05 1.01 1.19

5.43E-01 5.03E-01 5.06E-01 9.40E-01 2.72E-02

1.50 1.27 0.95 1.10 0.85

3.72E-02 2.10E-01 1.03E-01 7.24E-01 6.02E-02

0.75

2.38E-02

1.21

1.75E-01

1.86

1.80E-01

0.60 0.89 0.24 0.30 0.99 0.91 0.56 0.78 0.83 0.84 0.45 0.71 0.51 0.90 0.96


1.21 1.14 5.01 3.82 1.26 1.56 0.96 0.96 0.91 1.01 1.02 0.91 1.07 0.95 1.01


0.94 0.99 1.44 3.70 1.15 0.95 1.74 0.96 0.90 1.11 1.89 2.43 3.37 2.32 1.91


0.97 1.04 0.93 0.69

7.74E-01 8.17E-01 7.66E-01 1.16E-02

0.77 1.01 1.18 0.97

7.09E-02 9.09E-01 3.37E-01 7.97E-01

1.41 1.01 1.45 1.26

2.22E-01 7.47E-01 4.10E-01 1.37E-01

0.73 0.53 2.60 0.62 0.96

1.12E-02 4.08E-04 1.45E-03 2.77E-03 6.15E-01

1.02 0.90 1.10 1.29 1.03

6.89E-01 1.50E-01 1.68E-01 9.78E-02 8.56E-01

1.21 1.58 0.83 0.85 0.73

2.75E-01 5.14E-02 1.20E-01 6.69E-02 1.03E-02

MSMEG_2697 MSMEG_2698 MSMEG_2699 MSMEG_2700 MSMEG_2701 MSMEG_2702 MSMEG_2703 MSMEG_2704


conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein hydrogenase expression/formation protein HypD hydrogenase assembly chaperone HypC/HupF transposase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01548 hydrogenase expression/formation protein HypE phosphoheptose isomerase hypothetical protein hypothetical protein hypothetical protein hypothetical protein [NiFe] hydrogenase maturation protein HypF hydrogenase assembly chaperone HypC/HupF peptidase M52, hydrogen uptake protein hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein iron-sulfur cluster-binding protein, Rieske family protein, putative hydrogen:quinone oxidoreductase NADH ubiquinone oxidoreductase, 20 kda subunit hydrogenase accessory protein HypB hydrogenase nickel insertion protein HypA protein RecA regulatory protein RecX glutamate transporter permease protein GluD glutamate permease glutamate binding protein glutamate transport ATP-binding protein GluA tRNA-I(6)A37 thiotransferase enzyme MiaB

hypD hypC

hypE gmhA

hypF hypC

hypB hypA recA

miaB

0.84 1.17 0.43 1.09 3.08 3.59 6.99

5.46E-01 1.15E-01 1.12E-03 1.65E-01 1.76E-02 5.12E-03 3.83E-02

1.21 1.07 2.30 1.32 0.89 1.41 1.47

1.84E-01 1.22E-01 7.59E-02 1.52E-01 5.41E-01 2.68E-01 1.01E-01

0.71 0.56 1.09 1.30 1.70 2.38 3.48

2.46E-02 4.06E-04 6.93E-01 1.24E-01 1.46E-03 1.43E-02 2.84E-02

2.40 4.91 13.42 1.50 6.75 1.26 3.95 7.02 15.08 14.46 13.04 3.77 6.19 3.98

9.31E-04 2.10E-02 3.07E-02 1.26E-03 2.08E-02 1.39E-01 9.14E-02 5.85E-02 3.82E-02 1.06E-03 2.54E-02 1.21E-01 9.73E-02 3.06E-02

0.94 1.22 1.50 0.93 1.19 1.17 1.66 1.57 1.55 1.36 1.34 1.40 1.23 1.17

5.62E-01 3.04E-01 2.04E-01 6.94E-02 4.93E-01 2.55E-01 1.56E-01 2.22E-01 2.04E-01 3.74E-01 2.38E-01 3.75E-02 3.01E-01 3.93E-01

1.01 3.73 5.59 0.98 3.06 0.97 5.15 11.23 12.09 8.87 5.78 1.17 1.89 1.43

7.35E-01 1.40E-01 1.23E-04 9.05E-01 5.54E-02 5.57E-01 4.46E-02 1.37E-01 1.56E-02 2.94E-02 1.77E-02 3.38E-01 2.08E-02 2.77E-01

15.35 18.22

1.22E-02 7.22E-04

0.92 1.09

5.32E-01 7.42E-01

3.47 6.61

1.43E-02 1.07E-02

27.79 7.94 1.45 1.18 0.71 0.44 0.60 0.62 0.56 0.43

2.53E-03 4.32E-02 4.57E-03 3.39E-01 5.42E-02 3.49E-06 2.25E-03 3.10E-04 2.74E-04 4.43E-05

1.24 0.96 1.19 0.66 0.75 0.95 1.03 1.11 1.15 1.05

3.31E-01 8.08E-01 2.43E-01 1.18E-02 1.13E-01 5.42E-01 8.02E-01 2.31E-01 4.37E-03 2.39E-01

3.09 1.01 0.82 1.95 3.29 0.45 0.32 0.27 0.34 1.82

6.98E-02 8.96E-01 1.08E-01 1.58E-01 2.05E-02 4.12E-03 3.91E-04 2.62E-04 2.03E-04 2.18E-02

MSMEG_2730 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2730 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2731 ATPase involved in DNA repair MSMEG_2732 conserved hypothetical protein MSMEG_2733 conserved hypothetical protein MSMEG_2734 tRNA delta(2)-isopentenylpyrophosphate transferase MSMEG_2735 diaminopimelate epimerase MSMEG_2736 GTP-binding protein MSMEG_2737 ppe family protein MSMEG_2738 biotin sulfoxide reductase MSMEG_2739 conserved hypothetical protein MSMEG_2740 LexA repressor MSMEG_2741 hypothetical protein MSMEG_2742 DNA-damage-inducible protein MSMEG_2743 transcriptional regulator, NrdR family protein MSMEG_2744 thymidylate synthase MSMEG_2745 hydrolase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00561 MSMEG_2746 conserved hypothetical alanine and leucine rich protein MSMEG_2747 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2747 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2748 soluble pyridine nucleotide transhydrogenase MSMEG_2749 conserved hypothetical protein MSMEG_2750 iron-dependent repressor IdeR MSMEG_2751 hypothetical protein MSMEG_2752 sigma factor SigB MSMEG_2753 conserved hypothetical protein

miaA dapF

lexA nrdR

sthA

0.48

3.27E-04

0.83

1.39E-01

2.05

2.99E-02

0.63 1.13 0.59 0.62

3.93E-03 1.76E-01 1.12E-03 7.32E-03

1.12 1.02 0.91 0.93

3.81E-01 7.79E-01 4.50E-01 3.94E-01

1.23 0.65 1.04 1.18

6.24E-02 3.57E-02 6.43E-01 1.26E-01

0.56 1.16 1.40 2.55 1.08 1.05 2.00 1.69 1.65 1.13 3.16

6.02E-03 1.53E-01 2.33E-02 1.60E-02 4.06E-01 5.89E-01 7.40E-05 2.71E-01 1.50E-01 7.81E-02 3.36E-04

1.04 0.77 0.88 1.08 1.12 1.10 1.00 1.20 0.88 0.77 0.93

5.57E-01 8.01E-02 1.80E-01 4.53E-01 1.82E-01 2.74E-01 8.94E-01 5.12E-01 6.16E-03 1.07E-02 1.91E-01

1.47 1.25 1.52 0.47 1.43 0.78 2.39 3.36 3.60 2.88 0.87

4.19E-01 3.13E-01 4.86E-02 6.13E-02 2.54E-02 1.50E-02 5.14E-02 2.52E-01 1.18E-01 9.25E-02 4.35E-02

0.87

2.78E-02

1.10

2.49E-01

1.66

2.60E-01

1.32

1.25E-01

1.21

1.44E-01

1.13

4.56E-01

2.09

6.79E-03

0.65

2.45E-02

0.73

4.40E-02

1.32 1.00 1.16 2.10 0.50 1.81 2.23

4.86E-02 9.87E-01 2.82E-01 2.38E-04 6.61E-03 1.22E-03 8.21E-05

1.20 2.23 1.17 1.20 3.85 1.43 1.02

1.52E-01 1.15E-02 3.27E-01 8.48E-02 1.18E-01 1.21E-01 8.52E-01

1.15 0.72 0.97 1.19 1.23 1.72 1.13

1.01E-01 7.48E-02 5.95E-01 7.96E-03 3.58E-01 2.14E-02 5.34E-01


conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein glutathione S-transferase domain protein sigma factor MysA hypothetical protein polyphosphate glucokinase putative secreted alanine rich protein inositol-1-monophosphatase conserved hypothetical protein probable conserved alanine rich transmembrane protein deoxyuridine 5'-triphosphate nucleotidohydrolase conserved hypothetical protein conserved hypothetical protein OB-fold nucleic acid binding domain protein TrkB protein probable conserved integral membrane alanine and leucine rich protein TrkA protein amino acid permease hypothetical RNA methyltransferase diguanylate cyclase (ggdef) domain protein Na+/H+ antiporter NhaA 1-deoxy-D-xylulose-5-phosphate synthase alpha/beta hydrolase fold ribonuclease D ribonuclease D conserved hypothetical protein uroporphyrinogen decarboxylase protoporphyrinogen oxidase conserved hypothetical protein hypothetical protein methionine-R-sulfoxide reductase putative conserved integral membrane protein hydrolase, alpha/beta fold family protein putative riboflavin biosynthesis protein RibD ATP/GTP-binding integral membrane protein

nhaA dxs

hemE hemG msrB

2.10 0.84 1.30 2.98 1.37 1.17 0.86 0.88 0.80 2.10

1.35E-02 4.93E-02 1.14E-01 5.85E-03 2.97E-02 5.07E-01 1.64E-01 1.15E-01 5.12E-02 1.10E-02

0.87 1.53 1.06 0.61 0.70 0.77 0.89 0.87 0.93 0.99

2.18E-01 1.89E-02 6.68E-01 5.23E-03 2.22E-02 2.39E-01 2.77E-01 1.87E-01 6.41E-01 9.53E-01

0.91 2.42 3.52 6.87 1.30 5.63 0.63 0.83 0.91 1.10

6.59E-01 4.77E-03 1.36E-03 4.28E-03 3.36E-01 1.36E-01 5.19E-03 1.42E-01 5.01E-01 3.80E-01

0.69 0.80 0.68 1.48 1.62 0.95

1.05E-03 3.11E-02 1.74E-03 8.63E-04 3.25E-03 2.93E-01

0.95 1.40 1.16 0.99 0.80 0.94

6.97E-01 5.37E-02 1.70E-01 8.64E-01 7.64E-05 5.74E-01

1.02 2.41 2.36 1.65 3.26 1.30

7.61E-01 5.12E-03 1.20E-02 2.49E-01 4.50E-02 1.75E-01

1.02 0.86 1.83 1.08 2.43 1.24 1.16 0.67 0.61 0.82 0.81 0.82 0.79 0.66 1.24 2.20 0.47 0.67 1.18 0.42


0.93 0.90 0.79 0.80 0.73 0.84 0.86 0.85 1.20 0.94 1.06 1.03 1.01 1.01 0.98 0.86 0.91 1.06 0.81 0.94


3.76 1.58 1.46 2.97 0.92 1.48 1.13 1.34 5.10 2.78 2.06 1.37 1.30 2.55 1.27 0.85 0.80 0.96 0.98 2.99


MSMEG_2789 MSMEG_2790 MSMEG_2791 MSMEG_2792 MSMEG_2793 MSMEG_2794 MSMEG_2795 MSMEG_2796 MSMEG_2797 MSMEG_2798 MSMEG_2799 MSMEG_2800 MSMEG_2801 MSMEG_2802 MSMEG_2802 MSMEG_2803 MSMEG_2804 MSMEG_2805 MSMEG_2805 MSMEG_2805 MSMEG_2806 MSMEG_2807 MSMEG_2808 MSMEG_2809 MSMEG_2810 MSMEG_2811 MSMEG_2812 MSMEG_2813 MSMEG_2814

acetyltransferase, GNAT family protein conserved hypothetical protein pyridoxamine 5'-phosphate oxidase family Clp amino terminal domain protein sensor-type histidine kinase PrrB transcriptional regulator, GntR family protein transmembrane transport protein integral membrane protein LysR-family protein transcriptional regulator hypothetical protein phospho-2-dehydro-3-deoxyheptonate aldolase NADPH-dependent fmn reductase hypothetical protein hypothetical protein hypothetical protein hypothetical protein two-component system sensor kinase ISMsm5, transposase ISMsm5, transposase ISMsm5, transposase two-component system response regulator two-component system response regulator short-chain dehydrogenase/reductase SDR conserved hypothetical protein major facilitator superfamily protein hydride transferase 1 C-5 sterol desaturase sensor kinase two component system response regulator; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00072 MSMEG_2815 putative tape-measure protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error

0.87 1.11 2.82 0.88 0.49 1.58 0.76 1.35 1.01 0.80 0.27 0.52 1.19 0.82 1.07 0.83 0.87 1.10 0.93 1.04 1.01 0.97 0.85 1.05 0.95 2.13 0.96 1.23

2.73E-03 3.70E-01 1.04E-02 4.01E-03 3.50E-03 4.64E-01 4.89E-02 1.71E-01 9.30E-01 4.42E-01 2.02E-04 1.46E-04 8.14E-02 1.82E-01 6.09E-01 8.23E-02 1.24E-01 3.24E-02 2.89E-01 3.81E-01 8.81E-01 5.52E-01 6.04E-01 8.23E-01 6.38E-01 2.69E-02 6.99E-01 2.80E-01

0.87 0.89 0.65 1.14 1.04 0.96 0.91 0.92 0.84 0.60 0.89 1.06 1.07 0.93 0.97 0.86 1.15 1.08 0.95 0.98 0.98 1.13 1.28 1.34 1.02 1.00 1.05 0.88


1.00 0.29 0.69 0.97 1.43 1.00 1.09 1.84 1.15 1.05 1.61 0.84 1.11 0.66 1.37 0.77 0.79 0.47 0.57 0.66 1.04 1.47 1.02 1.08 1.31 1.06 1.02 1.22


1.98

1.47E-02

1.06

5.66E-01

1.51

6.00E-02

0.39

1.58E-04

2.01

4.41E-04

2.00

1.15E-02

MSMEG_2815 putative tape-measure protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_2816 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2817 ABC efflux pump, fused inner membrane and ATPase subunits MSMEG_2818 ISMsm1, transposase orfB MSMEG_2818 ISMsm1, transposase orfB MSMEG_2819 ISMsm1, transposase orfA MSMEG_2819 ISMsm1, transposase orfA MSMEG_2820 hypothetical protein MSMEG_2822 transposase, truncation MSMEG_2823 This gene is disrupted by an IS1549 element.; IS1549, transposase, interruption-N; identified by similarity to GP:2935133; match to protein family HMM PF01609 MSMEG_2823 This gene is disrupted by an IS1549 element.; IS1549, transposase, interruption-N; identified by similarity to GP:2935133; match to protein family HMM PF01609 MSMEG_2824 IS1549, transposase MSMEG_2824 IS1549, transposase MSMEG_2824 IS1549, transposase MSMEG_2824 IS1549, transposase MSMEG_2826 hypothetical protein MSMEG_2827 hypothetical protein MSMEG_2830 ISMsm4, transposase MSMEG_2830 ISMsm4, transposase MSMEG_2831 hypothetical protein MSMEG_2832 hypothetical protein MSMEG_2837 nitrate reductase NarB MSMEG_2838 conserved hypothetical protein MSMEG_2839 transcriptional accessory protein MSMEG_2840 conserved hypothetical protein MSMEG_2841 putative monooxygenase

0.91

4.18E-01

1.40

1.56E-01

1.27

9.41E-02

0.81

8.23E-02

1.06

5.82E-01

1.04

7.56E-01

0.94 0.58 0.90 1.45 0.95 0.88 0.67

6.29E-01 6.81E-04 3.05E-01 3.06E-01 7.70E-01 3.58E-02 3.15E-03

1.09 1.58 1.14 1.39 1.12 1.41 0.69

2.37E-01 1.25E-01 4.34E-01 2.28E-02 1.88E-01 2.31E-02 1.73E-02

1.37 1.17 1.00 1.09 0.90 3.23 0.85

3.87E-02 3.34E-01 9.67E-01 4.39E-01 5.07E-01 4.71E-01 4.29E-01

2.18

5.78E-02

1.50

4.03E-02

0.65

5.64E-02

2.02 0.75 1.45 0.91 1.11 1.51 1.04 0.82 1.08 1.41 2.43 1.40 1.08 0.33 1.22 1.11


1.35 1.45 0.69 1.07 0.88 1.57 1.06 1.52 1.11 0.93 0.90 1.49 1.50 1.34 0.92 1.39


0.84 1.69 2.15 1.07 1.00 0.31 1.10 0.68 1.06 1.38 0.89 0.95 0.87 1.31 1.12 1.75



nitrilotriacetate monooxygenase component A nitrilotriacetate monooxygenase component A ABC transporter, ATP-binding protein ABC transporter permease protein ABC transporter permease protein bacterial extracellular solute-binding protein, family protein 5 transmembrane efflux protein transcriptional regulatory protein mycobacterial family protein 11 protein conserved hypothetical protein 3-oxoacyl-[acyl-carrier-protein] reductase conserved hypothetical protein conserved hypothetical protein virulence factor Mce family protein virulence factor Mce family protein virulence factor Mce family protein virulence factor mce family protein virulence factor Mce family protein virulence factor mce family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein thioesterase family protein 3-ketosteroid dehydrogenase transcriptional regulator, PadR family protein 3-ketosteroid-delta-1-dehydrogenase oxygenase KshA conserved hypothetical protein short-chain dehydrogenase/reductase SDR 3-ketosteroid-delta4 conserved hypothetical protein esterase oxidoreductase, short chain dehydrogenase/reductase family protein conserved hypothetical protein

ssuD ssuD

1.55 1.33 1.34 1.24 0.94

4.16E-01 1.81E-01 2.99E-01 1.88E-01 5.78E-01

1.06 1.68 1.16 1.12 1.14

2.58E-01 3.76E-01 1.64E-01 4.99E-01 5.35E-01

1.50 1.09 1.37 0.92 1.03

3.90E-01 3.55E-01 3.40E-01 1.79E-01 8.48E-01

2.63 1.14 1.78 2.25 0.92 0.98 0.81 0.97 1.28 1.11 1.31 0.98 1.21 1.46 1.12 1.02 1.22 1.12 0.90 0.77 1.11 0.65 1.74 1.10 1.05 1.23 1.39 1.64 1.12

1.33E-01 3.73E-01 5.35E-02 2.09E-02 1.72E-01 8.97E-01 1.68E-02 6.51E-01 2.38E-01 4.59E-01 2.43E-01 8.68E-01 2.30E-01 1.95E-01 1.78E-01 6.04E-01 5.19E-02 5.33E-01 6.33E-01 2.00E-01 5.79E-01 1.57E-03 3.06E-01 5.67E-01 7.39E-01 2.77E-01 3.90E-01 1.13E-01 2.72E-01

1.17 0.93 0.84 0.99 1.28 1.11 1.51 1.19 1.18 1.24 1.07 1.32 1.16 1.40 1.15 1.48 0.87 1.23 1.17 1.24 1.21 1.13 0.91 1.01 1.25 1.92 1.37 0.86 1.14


1.00 1.00 1.01 0.88 1.07 1.26 4.30 1.01 1.01 1.65 1.17 1.89 1.07 0.88 1.49 2.21 1.00 1.09 1.10 1.27 1.02 1.07 1.03 0.91 1.76 0.99 1.32 0.94 0.98


0.95 1.07

6.05E-01 3.97E-01

0.96 1.07

7.73E-01 3.35E-01

2.07 0.93

3.92E-01 5.12E-01


putative acyl-CoA dehydrogenase acyl-CoA dehydrogenase enoyl-CoA hydratase aldehyde dehydrogenase 5-exo-alcohol dehydrogenase feruloyl-CoA synthetase cyclohexanone monooxygenase short-chain dehydrogenase/reductase SDR stress responsive A/B Barrel Domain family protein conserved hypothetical protein lipase NADH:flavin oxidoreductase/nadh oxidase putative transcriptional regulator biphenyl-2,3-diol 1,2-dioxygenase 1 pigment production hydroxylase oxidoreductase, NAD/FAD-binding steroid monooxygenase short chain oxidoreductase conserved hypothetical protein conserved hypothetical protein transcriptional regulator, TetR family protein oxidoreductase, short chain dehydrogenase/reductase family protein 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase conserved hypothetical protein hydrolase, putative transposase; this gene contains a frame shift which is not the result of sequencing error transposase; this gene contains a frame shift which is not the result of sequencing error transposase; this gene contains a frame shift which is not the result of sequencing error MmcI protein transcriptional regulator conserved hypothetical protein hypothetical oxidoreductase YeiQ

0.77 0.83 0.78 0.75 1.39 0.85 1.18 1.52

3.08E-02 2.27E-01 8.49E-02 4.03E-02 3.31E-01 4.22E-01 1.80E-01 4.62E-01

1.07 1.10 0.94 1.14 1.28 1.27 1.01 1.01

4.52E-01 5.47E-01 1.92E-01 5.55E-01 4.43E-01 2.53E-01 9.41E-01 8.87E-01

1.18 1.04 1.07 1.09 1.08 1.07 0.94 1.11

4.23E-01 5.56E-01 2.54E-01 4.16E-01 2.25E-01 1.88E-01 2.55E-01 5.10E-01

1.18 0.94 1.18 0.96 1.01 1.10 1.40 1.40 0.85 0.44 1.06 1.33 0.54

3.76E-01 6.07E-01 1.69E-01 8.09E-01 9.00E-01 2.06E-01 1.81E-01 1.27E-01 1.68E-01 1.63E-04 2.83E-01 4.18E-02 8.06E-03

0.98 1.15 1.20 1.13 1.13 1.18 1.02 1.45 1.07 1.01 0.68 1.04 1.04

8.68E-01 3.32E-01 3.95E-01 6.30E-02 4.40E-01 1.17E-01 7.96E-01 1.82E-01 5.98E-01 8.11E-01 4.27E-02 8.26E-01 6.47E-01

0.99 1.09 1.47 1.35 1.07 1.22 0.96 0.96 1.06 1.03 3.23 1.10 1.14

4.82E-01 3.66E-01 1.31E-01 3.10E-01 3.56E-01 2.78E-01 3.51E-01 3.83E-01 6.26E-01 8.19E-01 3.03E-01 6.53E-01 4.88E-01

0.44

5.09E-05

1.13

1.19E-01

1.32

4.19E-01

0.31 0.41 0.73

1.07E-05 4.93E-06 3.58E-02

1.06 1.14 1.30

7.25E-01 4.28E-01 2.84E-01

1.27 2.46 1.67

3.04E-01 3.61E-01 7.26E-02

1.47

5.84E-03

1.58

1.41E-01

1.23

1.31E-01

1.32

4.44E-02

1.37

2.53E-01

1.65

1.46E-01

1.01 2.10 1.84 1.12 1.06

7.62E-01 3.92E-02 2.25E-03 2.38E-01 6.93E-01

1.15 0.82 1.13 2.03 0.99

5.46E-01 1.31E-03 4.35E-01 1.60E-01 8.69E-01

1.09 1.57 1.30 1.03 1.00

3.75E-01 2.99E-01 1.62E-01 5.06E-01 9.87E-01


2-Keto-3-deoxy-gluconate kinase starvation-sensing protein RspA transcriptional regulator, GntR family protein integral membrane transport protein inner membrane metabolite transport protein YdfJ hydrolase L-idonate 5-dehydrogenase sensor histidine kinase DNA-binding response regulator, PhoP family protein hypothetical protein short-chain dehydrogenase/reductase SDR 2-dehydropantoate 2-reductase aldo/keto reductase NADPH-flavin oxidoreductase conserved hypothetical protein dehydrogenase/reductase SDR family protein member 1 permease binding-protein component permease membrane component glycine betaine/carnitine/choline transport ATPbinding protein opuCA ABC transporter, permease protein OpuCB conserved hypothetical protein thioesterase family protein conserved hypothetical protein TIGR02611 thrS threonyl-tRNA synthetase HIT family protein hydrolase phosphatidylinositol synthase lipid A biosynthesis lauroyl acyltransferase phosphatidylinositol alpha-mannosyltransferase hydrolase, nudix family protein pyridoxine biosynthesis protein tesB acyl-CoA thioesterase II glutamine amidotransferase subunit PdxT conserved hypothetical protein NAD dependent epimerase/dehydratase family protein

1.06 1.22 1.18 1.06 0.95 1.00 1.03 1.81

7.31E-01 1.56E-01 1.15E-01 7.45E-01 4.36E-01 9.88E-01 8.69E-01 2.30E-02

1.37 0.96 0.99 1.20 2.00 1.15 1.01 1.08

1.89E-01 7.95E-01 6.12E-01 3.10E-01 1.79E-01 1.11E-01 4.19E-01 4.89E-01

0.99 1.01 0.75 0.91 1.27 0.79 1.39 0.92

8.03E-01 8.84E-01 7.83E-02 4.44E-01 5.34E-01 1.18E-01 2.01E-01 3.96E-01

3.56 2.43 1.25 1.40 1.44 1.24 1.17

1.95E-01 1.47E-02 4.13E-01 1.21E-01 2.74E-02 2.97E-01 9.17E-02

0.96 0.85 1.07 0.97 3.31 1.87 1.04

5.77E-01 1.54E-01 4.88E-01 8.18E-01 6.76E-03 5.10E-02 3.85E-01

1.23 1.29 1.12 1.10 1.64 1.18 0.84

1.77E-01 2.67E-02 5.38E-01 1.06E-01 3.62E-02 1.71E-01 4.24E-02

0.44 1.32 0.90

1.88E-04 4.73E-01 6.71E-01

1.20 2.34 1.64

2.34E-01 2.58E-02 4.84E-02

1.14 0.66 1.13

5.17E-01 4.43E-02 6.18E-01

1.70 1.39 1.23 0.95 0.62 0.88 0.57 0.70 0.90 0.76 0.60 0.48 0.26 0.33 0.53


2.57 2.07 0.97 0.90 1.15 1.06 0.97 0.79 0.99 1.04 1.12 0.97 1.16 1.02 0.88


0.57 0.57 1.16 1.44 0.94 1.38 1.85 1.67 1.79 3.04 2.40 1.28 1.30 1.22 1.67


2.56

4.94E-02

1.00

9.90E-01

1.15

1.14E-01

MSMEG_2942 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein MSMEG_2943 crossover junction endodeoxyribonuclease RuvC MSMEG_2944 holliday junction DNA helicase RuvA MSMEG_2945 holliday junction DNA helicase RuvB MSMEG_2946 transmembrane protein MSMEG_2947 polyketide cyclase MSMEG_2948 6-oxocamphor hydrolase MSMEG_2949 carbon-monoxide dehydrogenase MSMEG_2950 carbon monoxide dehydrogenase, medium chain MSMEG_2951 [2Fe-2S] binding domain protein MSMEG_2952 transport gene MSMEG_2953 ethyl tert-butyl ether degradation EthD MSMEG_2954 LacI-family protein transcriptional regulator MSMEG_2955 conserved hypothetical protein MSMEG_2956 NAD dependent epimerase/dehydratase family protein MSMEG_2957 conserved hypothetical protein MSMEG_2958 conserved hypothetical protein MSMEG_2959 4-aminobutyrate transaminase MSMEG_2960 preprotein translocase, YajC subunit MSMEG_2961 protein-export membrane protein SecD MSMEG_2962 protein-export membrane protein SecF MSMEG_2963 bacterial extracellular solute-binding protein, family protein 5 MSMEG_2964 adenine phosphoribosyltransferase MSMEG_2965 GTP pyrophosphokinase MSMEG_2966 major facilitator family protein transporter MSMEG_2967 conserved hypothetical protein MSMEG_2968 conserved hypothetical protein MSMEG_2969 NADH:flavin oxidoreductase/nadh oxidase MSMEG_2970 polysaccharide deacetylase MSMEG_2971 regulatory protein MSMEG_2972 permease, cytosine/purines, uracil, thiamine, allantoin family protein MSMEG_2972 permease, cytosine/purines, uracil, thiamine, allantoin family protein MSMEG_2973 peptidyl-prolyl cis-trans isomerase

ruvC ruvA ruvB

gabT yajC secD

relA

1.53 0.91 0.66 0.97 0.88 2.47 1.99 1.66 1.92 1.07 0.87 1.28 1.01 0.70

1.57E-02 5.78E-01 1.49E-02 5.73E-01 2.15E-01 7.87E-03 6.74E-03 4.95E-03 6.19E-02 7.86E-01 4.44E-01 9.17E-02 9.55E-01 9.73E-04

1.10 0.98 0.90 0.92 0.90 0.84 0.91 1.06 1.20 2.60 1.27 1.25 1.10 1.35

5.05E-01 8.74E-01 2.79E-01 4.72E-01 1.72E-01 1.77E-01 4.49E-01 7.18E-01 3.58E-01 2.68E-01 3.24E-01 2.16E-01 5.04E-01 1.58E-01

0.99 3.71 4.10 1.87 1.92 0.62 1.09 1.05 1.34 0.94 1.05 0.80 0.82 1.55

8.98E-01 2.31E-02 2.51E-02 1.26E-01 9.10E-03 5.21E-02 5.97E-01 3.03E-01 4.38E-01 2.54E-01 2.03E-01 4.58E-02 4.14E-04 1.52E-01

0.84 1.34 2.48 1.99 1.04 0.63 0.55

2.89E-01 1.47E-02 1.60E-01 3.72E-03 3.74E-01 6.15E-04 6.88E-05

3.74 1.40 2.57 1.25 0.95 0.81 0.70

1.31E-01 1.15E-01 7.65E-02 6.11E-02 4.75E-01 4.21E-02 1.04E-02

1.04 0.95 0.51 0.32 1.16 0.96 1.55

8.22E-01 7.15E-01 5.80E-03 7.41E-07 1.97E-02 4.90E-01 6.49E-02

0.45 0.43 1.63 0.99 1.01 0.94 1.56 1.23 1.06

3.96E-04 3.45E-04 2.15E-02 9.12E-01 8.85E-01 4.26E-01 1.92E-01 1.04E-01 7.77E-01

1.13 1.01 1.07 3.03 4.27 1.39 1.28 1.41 6.04

5.02E-01 8.93E-01 3.66E-01 1.39E-01 7.76E-02 1.94E-01 2.37E-02 2.42E-01 9.81E-02

2.46 1.92 2.77 1.16 1.06 1.12 1.14 1.07 0.94

1.09E-01 4.13E-02 1.92E-02 4.47E-01 7.39E-01 1.59E-01 3.90E-01 3.75E-01 3.97E-01

1.21

2.91E-01

1.89

2.79E-02

1.06

2.84E-01

0.86 0.42

3.80E-01 1.27E-03

1.18 1.20

2.19E-01 1.02E-01

0.96 1.77

2.94E-01 1.14E-02

MSMEG_2974 peptidyl-prolyl cis-trans isomerase, cyclophilintype MSMEG_2975 metallo-beta-lactamase family protein hisS MSMEG_2976 histidyl-tRNA synthetase MSMEG_2977 hypothetical protein MSMEG_2978 ABC transporter ATP-binding protein MSMEG_2979 ABC transporter ATP-binding protein MSMEG_2980 putative membrane protein MSMEG_2981 branched-chain amino acid ABC-type transport system, permease component MSMEG_2982 putative periplasmic binding protein MSMEG_2983 conserved hypothetical protein MSMEG_2984 putative hydrolase MSMEG_2985 fumarate hydratase class I, anaerobic MSMEG_2986 amidohydrolase, AtzE family protein MSMEG_2987 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_2988 carbon-nitrogen hydrolase family protein MSMEG_2989 LacI family protein transcriptional regulator MSMEG_2990 Fe-S protein, radical SAM family protein MSMEG_2991 permease of the major facilitator superfamily protein MSMEG_2992 putative acyl-CoA dehydrogenase MSMEG_2993 acyl-CoA dehydrogenase, C- domain protein MSMEG_2994 amidohydrolase family protein MSMEG_2995 transcriptional regulator, TetR family protein MSMEG_2996 conserved hypothetical protein MSMEG_2997 conserved hypothetical protein MSMEG_2998 conserved hypothetical protein MSMEG_2998 conserved hypothetical protein MSMEG_2999 conserved protein MSMEG_3000 metallopeptidase, zinc binding MSMEG_3001 conserved hypothetical protein MSMEG_3002 para-nitrobenzyl esterase aspS MSMEG_3003 aspartyl-tRNA synthetase MSMEG_3004 conserved hypothetical protein TIGR00026 MSMEG_3005 hydroxyacyl-CoA dehydrogenase

0.50 1.22 0.94 0.31 0.18 0.17 0.15

1.09E-03 8.56E-02 7.51E-01 1.53E-04 1.78E-04 1.45E-04 8.35E-05

0.95 0.90 0.79 1.19 2.06 2.39 4.13

4.86E-01 7.26E-02 1.01E-02 1.63E-01 3.21E-01 2.68E-01 3.44E-01

0.68 2.07 2.45 1.03 0.83 0.82 0.90

3.93E-02 1.10E-02 1.54E-03 5.16E-01 1.95E-01 1.47E-01 7.36E-01

0.12 0.11 0.75 0.75 1.95 0.89

8.45E-06 3.83E-06 9.12E-03 5.16E-02 5.57E-02 4.58E-01

1.58 2.67 0.77 1.31 1.41 1.11

1.78E-01 2.96E-01 1.88E-02 3.66E-01 2.92E-01 6.23E-01

0.95 0.59 1.07 1.21 1.00 1.05

7.60E-01 8.26E-02 5.32E-01 5.77E-01 9.43E-01 2.90E-01

1.37 1.16 1.02 1.08

6.74E-02 3.03E-01 7.55E-01 4.97E-01

1.57 1.64 0.77 0.93

5.04E-02 1.84E-01 6.68E-03 2.51E-01

1.09 1.52 0.88 1.07

6.67E-01 2.76E-01 2.30E-01 6.50E-02

0.93 2.05 1.13 1.57 5.29 3.56 1.94 1.51 1.25 0.77 1.13 0.87 1.43 0.51 1.95 4.41


1.38 2.35 1.83 1.80 1.47 1.04 1.03 1.29 0.94 1.67 1.34 1.94 1.05 0.86 0.80 2.27


1.02 1.00 1.00 0.95 0.68 0.87 1.47 1.60 0.92 1.65 1.27 1.95 1.16 1.38 1.81 1.39



Fe-dependent alcohol dehydrogenase succinate-semialdehyde dehydrogenase putative sigma 54 type regulator 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase acetyl-hydrolase steroid monooxygenase acetyl-CoA acetyltransferases putative transcriptional regulator family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein transglutaminase domain protein conserved hypothetical protein conserved hypothetical protein AAA ATPase, central region transglycosylase associated protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein alanyl-tRNA synthetase conserved hypothetical protein conserved hypothetical protein shikimate-5-dehydrogenase peptidase, A24 (type IV prepilin peptidase) family protein chorismate synthase shikimate kinase conserved hypothetical protein 3-dehydroquinate synthase metallopeptidase, M24 family protein translation elongation factor P transcription antitermination factor NusB

alaS aroE aroC aroB efp nusB

6.29 5.40 4.51

7.64E-03 1.20E-03 3.30E-03

2.05 2.82 1.17

1.32E-01 9.87E-02 1.05E-01

1.21 3.33 0.67

2.29E-01 1.61E-02 4.22E-03

1.04 1.43 1.25 1.33 1.26 6.17 0.61 1.15 0.74 0.75 0.72 0.57 0.81 2.66

7.05E-01 4.94E-01 3.51E-02 3.43E-01 1.36E-01 8.52E-04 1.59E-02 7.37E-01 8.88E-03 5.21E-03 3.40E-02 1.26E-02 1.24E-01 2.84E-01

7.32 1.06 1.14 20.96 0.92 0.95 0.96 1.35 1.08 0.76 1.02 0.76 1.03 2.53

1.45E-01 3.55E-01 3.97E-01 8.21E-02 2.58E-01 6.03E-01 8.35E-01 2.03E-01 3.83E-01 6.86E-02 8.47E-01 4.60E-02 5.49E-01 4.05E-02

1.23 1.05 1.31 1.84 1.09 1.02 3.93 1.05 3.73 1.77 1.40 1.88 1.69 0.48

5.34E-01 6.20E-01 2.81E-01 3.83E-01 2.61E-01 8.48E-01 1.96E-02 7.85E-01 1.21E-01 1.73E-01 1.32E-01 2.29E-01 1.18E-02 9.62E-04

4.52 1.05 0.60 0.70 0.50 0.41

1.55E-03 7.31E-01 2.03E-04 4.75E-04 6.69E-05 5.49E-06

0.98 0.84 1.12 0.93 0.93 0.85

8.90E-01 1.70E-01 7.68E-03 4.73E-02 3.78E-01 5.08E-03

0.78 2.22 1.82 2.58 2.67 3.29

1.37E-01 2.93E-02 7.78E-03 1.60E-02 1.04E-02 8.69E-02

0.82 0.74 0.94 0.83 0.68 0.71 0.52 0.31

2.94E-01 3.07E-04 1.16E-01 3.59E-03 1.80E-01 1.25E-02 1.32E-04 1.32E-05

1.07 1.01 0.91 1.03 1.05 1.08 1.01 0.96

5.07E-01 9.05E-01 1.68E-02 7.73E-01 7.78E-01 9.06E-02 8.42E-01 5.03E-01

1.16 2.03 1.86 0.20 2.08 1.52 0.80 1.28

5.67E-01 1.31E-02 2.43E-02 6.63E-06 1.67E-01 2.73E-02 1.99E-02 2.36E-02

MSMEG_3037 regulatory protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00196 MSMEG_3038 hypothetical protein MSMEG_3039 monooxygenase MSMEG_3040 beta-lactamase MSMEG_3041 thiopurine S-methyltransferase (tpmt) superfamily protein MSMEG_3042 PyrR bifunctional protein MSMEG_3043 aspartate carbamoyltransferase MSMEG_3044 dihydroorotase MSMEG_3045 integral membrane protein MSMEG_3046 carbamoyl-phosphate synthase, small subunit MSMEG_3047 carbamoyl-phosphate synthase, large subunit MSMEG_3048 orotidine 5'-phosphate decarboxylase MSMEG_3049 hypothetical protein MSMEG_3050 integration host factor MSMEG_3051 guanylate kinase MSMEG_3052 hypothetical protein MSMEG_3053 DNA-directed RNA polymerase, omega subunit MSMEG_3054 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase MSMEG_3055 S-adenosylmethionine synthetase MSMEG_3056 ABC transporter ATP-binding protein MSMEG_3057 ABC-type metal ion transport system, permease component MSMEG_3058 lipoprotein, nlpa family protein MSMEG_3058 lipoprotein, nlpa family protein MSMEG_3059 esterase MSMEG_3060 conserved hypothetical protein MSMEG_3061 primosomal protein N' MSMEG_3062 conserved hypothetical protein MSMEG_3063 LemA protein MSMEG_3064 methionyl-tRNA formyltransferase MSMEG_3065 ribosomal RNA small subunit methyltransferase B

2.13 0.85 1.20 0.56

9.30E-03 4.04E-03 1.90E-01 3.27E-03

1.24 0.82 1.22 0.87

3.57E-02 9.88E-02 2.09E-01 3.56E-02

1.47 0.91 0.51 0.89

1.20E-01 3.30E-01 1.08E-02 4.82E-01

2.55 0.68 0.51 0.45 0.44 0.42 0.33 0.26 1.18 1.06 1.03 1.11 1.32

2.22E-02 9.40E-03 6.58E-05 3.70E-04 7.13E-05 6.53E-05 4.52E-05 2.96E-05 5.49E-01 5.24E-01 6.70E-01 3.64E-01 6.30E-04

0.99 0.97 1.03 0.99 1.22 1.31 1.47 0.82 1.06 0.72 0.90 0.98 0.80

9.48E-01 5.94E-01 8.35E-01 9.75E-01 3.19E-01 2.01E-01 2.82E-01 1.23E-01 6.62E-01 1.24E-01 2.56E-01 9.11E-01 2.41E-03

1.20 1.96 2.76 3.13 2.67 1.56 1.75 2.74 1.22 0.91 0.67 1.24 1.51

3.67E-01 3.75E-02 2.69E-03 8.88E-04 1.78E-01 1.60E-03 2.73E-02 2.03E-02 4.35E-01 6.56E-01 1.11E-02 1.12E-01 5.33E-04

0.96 0.57 0.58

5.24E-01 2.99E-05 2.52E-03

0.92 1.25 1.78

1.85E-01 1.55E-01 1.81E-01

1.62 1.69 2.64

5.38E-02 3.50E-02 8.24E-03

fmt

0.35 0.33 0.36 0.63 1.01 0.67 1.00 1.25 1.33

2.46E-04 8.71E-05 1.68E-04 6.16E-04 8.61E-01 5.87E-04 9.69E-01 1.06E-01 6.36E-01

1.39 1.28 1.13 0.98 0.87 0.92 1.09 0.87 0.97

3.49E-01 3.24E-01 5.61E-01 8.45E-01 5.71E-02 1.61E-02 6.16E-01 1.15E-01 1.25E-01

1.91 1.49 1.16 1.33 1.17 1.42 1.29 0.98 2.18

3.78E-02 2.16E-01 4.54E-01 1.12E-01 2.53E-01 3.71E-01 2.10E-01 8.80E-01 1.11E-01

sun

0.54

4.47E-04

0.88

3.13E-02

2.00

7.00E-04

pyrB carA carB pyrF

rpoZ coaBC metK

priA


ribulose-phosphate 3-epimerase riboflavin biosynthesis protein RibD hypothetical protein aminoglycosides/tetracycline-transport integral membrane protein LprG protein riboflavin synthase, alpha subunit riboflavin biosynthesis protein ribAB 6,7-dimethyl-8-ribityllumazine synthase conserved hypothetical protein acetyltransferase, GNAT family protein gamma-glutamyltransferase hypothetical protein excinuclease ABC, C subunit conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein soul heme-binding protein nucleoside-diphosphate sugar epimerase glyceraldehyde-3-phosphate dehydrogenase, type phosphoglycerate kinase triosephosphate isomerase preprotein translocase, SecG subunit O-methyltransferase; this gene contains a premature stop which is not the result of sequencing error O-methyltransferase; this gene contains a premature stop which is not the result of sequencing error deoxyribose-phosphate aldolase ribose transport system permease protein RbsC ribose transport ATP-binding protein RbsA transcriptional regulator, sugar-binding family protein putative sugar kinase protein oxidoreductase, zinc-binding dehydrogenase family protein D-ribose-binding periplasmic protein

rpe ribD

ribE ribE ggt uvrC

gap pgk tpiA secG

deoC

0.73 1.75 1.84

1.35E-02 4.33E-01 1.42E-02

0.83 0.87 0.56

1.79E-03 7.47E-03 4.43E-03

1.23 1.96 3.27

1.25E-01 1.02E-01 1.53E-03

0.49 0.70 0.42 0.73 0.64 0.47 1.27 1.61 1.05 1.24 1.26 1.04 0.75 0.89 1.12 0.38 0.32 0.35 0.50


1.04 1.05 0.97 0.89 0.88 0.90 1.04 1.20 1.44 0.81 0.85 0.75 0.86 1.14 1.28 0.98 1.04 0.99 0.83


1.55 1.56 3.88 2.04 4.09 4.51 1.56 1.22 0.97 6.52 3.61 3.67 2.65 1.69 1.11 1.14 1.58 1.93 2.27


1.74

1.06E-02

1.09

1.12E-01

1.17

1.37E-01

1.10 1.34 1.00 1.24

5.98E-01 3.09E-01 9.80E-01 2.27E-01

0.89 0.86 0.97 0.97

3.19E-01 1.08E-01 7.44E-01 6.85E-01

1.09 0.98 0.75 0.98

2.61E-01 6.09E-01 1.67E-01 6.34E-01

0.97 1.64

4.01E-01 3.88E-01

1.34 0.98

9.23E-02 8.58E-01

1.04 0.95

1.66E-01 6.96E-01

1.07 1.63

8.66E-02 2.53E-03

1.05 0.87

5.87E-01 2.68E-01

0.55 0.78

3.20E-02 2.67E-01


hypothetical protein phosphoenolpyruvate carboxylase conserved hypothetical protein 6-phosphogluconolactonase OpcA protein glucose-6-phosphate 1-dehydrogenase transaldolase transketolase hypothetical protein protoheme IX farnesyltransferase quinone oxidoreductase conserved hypothetical protein ABC transporter, ATPase subunit binding-protein-dependent transport systems inner membrane component binding-protein-dependent transport systems inner membrane component extracellular solute-binding protein, family protein 1 estradiol 17-beta-dehydrogenase 8 carbohydrate kinase, fggy conserved hypothetical protein regulatory protein, DeoR inositol-1-monophosphatase cytochrome aa3 controlling protein ABC transporter efflux protein, DrrB family protein ABC transporter, ATP-binding subunit conserved hypothetical protein DNA-binding protein FeS assembly protein SufB FeS assembly protein SufD FeS assembly ATPase SufC cysteine desulfurase SUF system FeS assembly protein, NifU family protein conserved protein, DUF59 hypothetical protein

ppc pgl opcA zwf tal tkt cyoE

sufB sufD sufC

1.48 0.61 0.74 0.71 0.68 0.59 0.93 0.88 0.83 0.44 1.01 0.62 0.86

7.30E-02 1.16E-03 8.93E-02 1.32E-03 5.25E-04 1.35E-04 3.83E-01 1.39E-01 3.30E-01 5.58E-06 8.94E-01 1.22E-03 6.28E-02

1.06 0.95 1.21 1.04 1.13 1.12 1.16 0.81 1.20 0.80 0.77 0.90 1.00

8.14E-01 6.08E-01 2.95E-02 6.80E-01 2.50E-01 1.71E-01 4.05E-02 1.61E-02 5.22E-02 7.02E-02 2.39E-02 2.19E-01 9.84E-01

1.57 1.49 0.85 0.89 1.04 1.10 0.89 0.64 1.51 3.69 1.39 1.28 1.03

2.67E-01 2.96E-03 1.74E-01 8.21E-02 7.47E-01 1.90E-01 3.14E-01 6.75E-04 1.65E-01 2.73E-02 2.92E-02 3.73E-01 7.07E-01

0.94

6.70E-01

1.17

7.79E-02

1.28

1.78E-01

1.09

4.79E-01

1.11

5.03E-01

0.99

8.05E-01

0.89 0.70 1.44 0.71 0.78 1.42 0.33

2.61E-01 5.43E-03 1.91E-02 5.15E-02 8.35E-02 3.33E-01 1.39E-04

0.94 0.87 1.09 1.17 1.20 1.03 1.03

2.88E-01 3.84E-02 2.36E-01 3.88E-01 3.20E-01 8.68E-01 8.69E-01

0.84 1.30 1.01 0.93 0.86 1.52 11.96

1.98E-01 1.81E-01 6.73E-01 2.53E-01 3.44E-01 3.31E-01 9.60E-03

0.59 0.50 0.63 1.38 1.18 1.23 1.03 0.89

9.56E-03 3.61E-04 1.97E-03 1.47E-03 1.05E-01 8.89E-02 6.80E-01 3.52E-01

1.36 1.01 0.94 0.55 0.70 0.60 0.52 0.58

4.82E-01 8.42E-01 5.67E-01 1.74E-04 7.20E-03 1.87E-03 4.30E-04 2.96E-04

1.36 1.77 1.95 0.77 0.79 0.82 0.77 1.40

4.55E-02 4.61E-02 3.15E-01 2.49E-02 1.67E-02 8.76E-03 9.48E-03 6.84E-03

0.85 0.93 0.76

5.34E-02 1.12E-01 2.99E-02

0.61 0.66 1.15

3.42E-04 4.44E-04 3.60E-01

1.17 0.93 1.08

1.36E-01 2.29E-01 4.38E-01


putative HTH-type transcriptional regulator hypothetical protein AMP-binding protein DNA-binding protein hypothetical protein cytochrome P450 107B1 hypothetical protein heme peroxidase superfamily protein oxidoreductase thioredoxin enoyl-CoA hydratase/isomerase ABC transporter ATP-binding protein, possibly in EF-3 subfamily protein conserved domain protein HTH-type transcriptional repressor AcnR aconitate hydratase 1 putative membrane protein secreted cell wall-associated hydrolase invasin 1 ATPase, MoxR family protein conserved hypothetical protein conserved hypothetical protein 3-oxoacyl-(acyl-carrier-protein) reductase [NADH] enoyl-[acyl-carrier-protein] reductase ferrochelatase conserved hypothetical protein membrane protein implicated in regulation of membrane protease activity band 7 protein conserved hypothetical protein conserved hypothetical protein methylmalonyl-CoA mutase, small subunit methylmalonyl-CoA mutase large subunit LAO/AO transport system ATPase conserved hypothetical protein beta-lactamase gp55 protein hypothetical protein

trx

acnA

moxR fabG hemH

mutA

1.10 0.95 0.87 1.54 1.29 1.72 1.29 1.35 2.70 2.50 0.52

1.73E-01 7.16E-01 2.41E-01 2.24E-02 3.42E-01 2.50E-02 2.10E-01 2.31E-01 2.34E-03 5.59E-03 2.92E-03

1.08 1.21 1.30 1.09 1.20 1.19 1.02 1.00 2.01 1.02 7.49

2.30E-01 2.98E-01 1.08E-01 3.03E-01 2.94E-01 5.46E-01 7.80E-01 9.81E-01 2.09E-01 8.95E-01 7.68E-02

0.96 1.05 1.02 1.19 0.94 0.81 1.05 0.87 0.90 0.57 1.55

8.60E-01 8.40E-01 1.86E-01 1.63E-01 3.69E-01 3.74E-01 5.90E-01 3.45E-01 2.18E-01 6.86E-05 9.83E-02

0.56 3.72 0.66 0.90 0.66 0.94 0.68 1.00 0.65 0.46 0.38 0.36 0.25 1.35

3.00E-04 3.04E-02 9.55E-04 2.06E-02 9.01E-02 6.54E-01 2.00E-02 9.96E-01 5.76E-04 2.85E-06 2.06E-07 2.14E-05 3.38E-07 5.02E-03

3.05 3.38 1.14 1.46 1.42 1.03 1.19 0.85 1.00 1.12 1.11 0.95 1.02 0.93

1.37E-01 8.48E-02 3.29E-01 1.55E-01 2.28E-01 8.31E-01 5.13E-01 9.99E-02 9.63E-01 2.76E-01 2.78E-01 5.32E-01 8.72E-01 4.40E-01

4.43 0.46 1.90 1.48 1.00 0.70 1.11 1.28 1.70 1.42 1.66 2.29 2.46 0.92

7.33E-03 2.03E-02 4.58E-04 1.01E-03 9.91E-01 4.60E-02 6.89E-01 3.18E-01 3.00E-03 3.73E-03 6.22E-02 1.45E-03 1.21E-02 6.51E-01

1.58 1.21 0.95 0.82 0.49 0.40 0.39 0.19 4.60 1.17 1.76

3.87E-03 1.94E-03 6.11E-01 5.83E-03 5.15E-03 1.35E-04 6.77E-06 1.57E-05 9.01E-04 3.03E-01 2.26E-02

1.01 1.04 1.10 0.83 1.10 1.07 1.17 1.18 0.81 0.92 1.29

9.35E-01 5.35E-01 3.33E-01 5.99E-02 3.41E-01 4.54E-01 2.75E-01 1.06E-01 8.93E-03 4.38E-01 9.85E-03

0.76 0.49 1.10 1.42 0.99 0.81 1.12 0.99 0.22 0.32 0.22

9.17E-02 3.54E-04 3.37E-01 1.33E-01 9.59E-01 1.53E-01 6.69E-01 8.92E-01 7.08E-04 2.49E-04 2.54E-05

MSMEG_3168 phenolpthIocerol synthesis type-i polyketide synthase ppse ileS MSMEG_3169 isoleucyl-tRNA synthetase MSMEG_3170 conserved domain protein MSMEG_3171 conserved hypothetical protein MSMEG_3172 DNA polymerase IV 1 MSMEG_3173 L-asparaginase MSMEG_3174 lipoprotein signal peptidase MSMEG_3175 ribosomal large subunit pseudouridine synthase D MSMEG_3176 RarD protein MSMEG_3177 probable transcriptional regulatory protein, putative MSMEG_3178 DNA polymerase III alpha subunit MSMEG_3179 pyridoxamine 5'-phosphate oxidase family MSMEG_3180 transcriptional regulator, MerR family protein MSMEG_3181 conserved hypothetical protein MSMEG_3182 hypothetical protein MSMEG_3183 threonine dehydratase MSMEG_3184 malto-oligosyltrehalose trehalohydrolase MSMEG_3185 putative maltooligosyl trehalose synthase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00128 MSMEG_3185 putative maltooligosyl trehalose synthase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00128 MSMEG_3186 glycogen debranching enzyme GlgX MSMEG_3187 putative acyltransferase domain protein MSMEG_3188 adenosylmethionine-8-amino-7-oxononanoate transaminase MSMEG_3189 8-amino-7-oxononanoate synthase MSMEG_3190 dethiobiotin synthase MSMEG_3191 conserved hypothetical protein MSMEG_3192 conserved hypothetical protein, putative MSMEG_3193 transcriptional regulator, TetR family protein MSMEG_3194 biotin synthase

0.97 0.33 1.07 7.90 0.87 0.75 0.94

6.81E-01 4.36E-06 4.53E-01 1.15E-04 2.34E-02 4.12E-02 3.10E-01

1.10 1.12 1.09 0.75 0.98 1.00 0.81

4.85E-01 1.58E-01 6.34E-01 9.09E-02 8.46E-01 9.50E-01 3.79E-02

0.90 1.74 1.99 0.75 1.77 2.05 1.74

2.50E-01 7.84E-03 8.06E-02 4.49E-02 9.94E-02 2.27E-02 2.56E-02

rarD

0.62 0.48

5.30E-04 1.17E-05

1.01 0.93

7.76E-01 5.17E-01

2.56 2.43

5.32E-02 1.40E-02

ilvA treZ

0.89 0.91 1.15 1.92 2.18 1.09 1.23 0.88

4.33E-01 1.59E-01 4.05E-01 3.90E-06 1.86E-04 6.41E-01 8.92E-02 3.15E-01

1.34 0.99 1.26 1.18 0.87 1.23 1.15 1.31

1.33E-01 8.54E-01 1.54E-02 1.19E-01 5.11E-02 3.21E-01 6.15E-02 4.92E-02

1.34 1.59 0.97 0.36 1.23 1.15 1.53 1.03

3.23E-01 1.07E-01 4.49E-01 2.16E-04 1.08E-01 2.22E-01 8.93E-02 8.41E-01

0.65

1.11E-02

1.55

1.83E-02

1.39

3.75E-01

0.74 0.73 0.88

5.48E-02 9.64E-03 7.74E-02

1.33 1.54 0.92

6.22E-02 6.86E-02 3.38E-01

1.05 0.84 1.41

8.40E-01 5.13E-01 1.05E-03

0.47 0.41 0.87 1.45 2.05 0.66 0.49

2.59E-05 8.56E-04 4.09E-01 1.75E-01 1.96E-03 4.45E-04 6.00E-03

1.12 1.19 1.30 1.13 0.95 0.94 1.16

5.90E-01 3.46E-01 9.56E-02 1.72E-01 1.18E-01 6.44E-01 2.27E-01

1.23 1.10 1.36 1.37 1.01 1.06 1.23

2.17E-01 3.45E-01 1.23E-01 3.37E-01 9.37E-01 7.19E-01 3.38E-01

glgX bioA bioF bioD

bioB


conserved hypothetical protein conserved hypothetical protein lipase hydrolase, NUDIX family protein quinolinate synthetase complex, A subunit L-aspartate oxidase nicotinate-nucleotide pyrophosphorylase hypothetical protein transporter, LysE family protein conserved hypothetical protein histidinol dehydrogenase histidinol-phosphate aminotransferase imidazoleglycerol-phosphate dehydratase imidazole glycerol phosphate synthase, glutamine amidotransferase subunit bifunctional HisA/TrpF protein inositol monophosphate phosphatase imidazoleglycerol phosphate synthase, cyclase subunit phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase conserved hypothetical protein hypothetical protein ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA peroxiredoxin Q anthranilate synthase component I trp region conserved hypothetical membrane protein indole-3-glycerol phosphate synthase tryptophan synthase, beta subunit tryptophan synthase, alpha subunit prolipoprotein diacylglyceryl transferase TM2 domain protein conserved hypothetical protein ferredoxin-dependent glutamate synthase 1 glutamate synthase, NADH/nadph, small subunit

0.76 0.91 1.21 0.62 0.66 0.71 0.94 1.24 0.81 1.84 1.00 0.94 0.96

5.13E-04 1.51E-01 8.32E-02 4.94E-03 1.19E-02 2.13E-03 5.89E-01 5.11E-01 4.75E-02 9.98E-06 9.85E-01 7.84E-01 5.28E-01

0.83 0.88 0.60 1.01 1.11 1.09 1.10 1.04 1.06 0.73 0.99 0.80 0.89

6.40E-02 2.57E-01 8.44E-03 9.02E-01 3.29E-01 5.65E-01 4.09E-01 6.70E-01 6.64E-01 2.25E-02 8.45E-01 2.89E-03 2.98E-01

1.49 1.50 0.71 1.30 0.71 1.11 1.06 1.03 0.98 0.71 1.15 1.35 1.72

1.33E-01 2.50E-02 8.19E-02 1.16E-01 8.84E-03 2.54E-01 7.98E-01 7.94E-01 5.79E-01 1.24E-01 4.68E-01 7.18E-03 1.36E-01

hisH

0.73 0.71 0.46

1.17E-02 3.88E-02 8.33E-05

0.98 0.74 0.94

5.72E-01 4.29E-02 2.49E-01

2.61 1.92 2.16

2.46E-04 1.01E-02 2.22E-02

hisF

0.58

5.10E-04

0.93

3.82E-01

2.11

1.03E-01

hisIE

0.52 0.65 0.62

1.05E-04 1.37E-02 3.63E-03

1.00 1.00 0.92

9.36E-01 9.85E-01 5.87E-01

1.83 1.18 1.99

5.07E-03 7.37E-02 2.74E-01

0.84 0.64 0.62

3.33E-02 1.56E-03 5.67E-04

0.83 1.06 0.86

1.38E-01 6.24E-01 4.44E-02

1.03 1.52 1.61

8.71E-01 9.95E-02 3.70E-04

0.47 0.85 0.58 0.55 0.39 1.71 1.40 0.50 0.87

8.76E-05 1.38E-01 2.81E-03 2.26E-04 2.40E-06 6.60E-03 7.45E-02 1.65E-02 4.40E-01

1.06 0.74 0.92 0.84 1.13 0.85 0.69 1.15 1.01

6.51E-01 3.14E-03 3.90E-01 3.86E-02 2.78E-01 9.24E-02 2.02E-02 4.67E-01 9.45E-01

1.26 1.34 1.98 2.63 2.34 0.97 1.23 1.06 1.87

1.87E-01 3.54E-03 9.70E-04 7.90E-03 6.52E-03 9.07E-01 5.68E-01 8.48E-01 1.90E-01

nadA nadB nadC

hisD hisC hisB

trpE trpC trpB trpA

MSMEG_3227 MSMEG_3228 MSMEG_3229 MSMEG_3230

MSMEG_3231 MSMEG_3232 MSMEG_3233 MSMEG_3234 MSMEG_3235 MSMEG_3236 MSMEG_3237 MSMEG_3238 MSMEG_3239 MSMEG_3240 MSMEG_3241 MSMEG_3242 MSMEG_3243


pyk pyruvate kinase acyl-CoA thioesterase II conserved hypothetical protein ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00005; match to protein family HMM TIGR02868 ABC transporter, CydDC cysteine exporter (CydDC-E) family protein, permease/ATPcydD binding protein CydD cydB cytochrome D ubiquinol oxidase, subunit II cytochrome D ubiquinol oxidase subunit 1 integral membrane protein ABC-type amino acid transport system, secreted component ABC-type amino acid transport system, permease component ATP-binding protein 3-mercaptopyruvate sulfurtransferase two-component system sensor kinase DNA-binding response regulator, LuxR family protein conserved hypothetical protein starvation-inducible DNA-binding protein or fine tangled pili major subunit adenylate cyclase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00211 hypothetical protein response regulator branched-chain amino acid ABC transporter substrate-binding protein ABC transporter branched chain amino acid transport permease

0.87 0.44 2.12

6.40E-02 1.65E-04 6.95E-03

1.08 1.25 0.91

5.21E-01 3.39E-02 4.04E-01

0.86 2.07 5.20

2.46E-01 8.44E-02 1.41E-03

0.52

1.12E-02

1.01

9.29E-01

93.33

2.36E-02

0.52 0.23 0.34 1.80

2.20E-02 4.15E-06 2.26E-05 3.26E-03

1.08 1.03 0.90 0.84

5.85E-01 6.99E-01 2.51E-01 6.18E-02

62.22 159.29 48.86 0.59

5.79E-03 2.89E-02 6.01E-02 1.68E-03

0.57

1.71E-05

1.10

2.83E-01

0.31

3.55E-04

0.67 0.63 1.04 1.26

4.48E-04 3.38E-03 6.96E-01 2.07E-02

1.03 0.89 0.65 0.96

2.31E-01 2.27E-01 1.24E-02 5.29E-01

0.26 0.41 1.30 1.63

8.89E-06 1.26E-04 2.29E-02 1.63E-03

1.17 0.96

2.94E-01 4.27E-01

0.93 1.02

4.66E-01 7.43E-01

1.34 1.17

7.96E-03 3.80E-01

1.39

1.86E-01

20.89

1.25E-01

0.64

3.58E-02

1.24 2.28 1.11

2.98E-01 3.15E-04 2.14E-01

1.12 4.74 1.35

4.90E-01 8.27E-02 9.36E-02

1.27 1.57 1.43

4.42E-01 5.45E-02 8.95E-02

0.43

1.66E-05

1.43

5.13E-02

0.52

7.68E-03

0.25

1.23E-06

1.18

5.17E-01

0.65

1.39E-01

MSMEG_3249 branched-chain amino acid ABC transporter, permease protein MSMEG_3250 ABC transporter, ATP-binding protein MSMEG_3251 branched-chain amino acid ABC transporter ATPbinding protein MSMEG_3252 membrane protein MSMEG_3253 conserved hypothetical protein MSMEG_3254 RDD family protein, putative MSMEG_3255 DoxX subfamily protein, putative MSMEG_3256 mucin-associated surface protein xylB MSMEG_3257 xylulokinase MSMEG_3258 hypothetical protein MSMEG_3259 acyl-CoA dehydrogenase MSMEG_3260 LysR-family protein transcriptional regulator MSMEG_3261 conserved hypothetical protein MSMEG_3262 L-xylulose reductase MSMEG_3263 xylulose kinase MSMEG_3264 transcriptional regulator MSMEG_3265 arabitol-phosphate dehydrogenase MSMEG_3266 maltose/maltodextrin-binding protein MSMEG_3267 transporter MSMEG_3268 ABC transporter, permease protein MSMEG_3269 putative sugar ABC transporter ATP-binding protein MSMEG_3270 SN-glycerol-3-phosphate ABC transporter, ATPbinding protein MSMEG_3271 dihydroxyacetone kinase MSMEG_3272 ribose 5-phosphate isomerase MSMEG_3273 glutamyl aminopeptidase, M42 family protein MSMEG_3274 MerR-family protein transcriptional regulator MSMEG_3275 RNA polymerase sigma factor, sigma-70 family protein MSMEG_3276 integral membrane protein MSMEG_3277 polyamine ABC transporter integral membrane protein MSMEG_3278 conserved hypothetical protein MSMEG_3279 polyamine ABC transporter permease protein MSMEG_3280 polyamine-binding lipoprotein

0.24 0.34

6.63E-07 1.90E-06

1.39 1.25

2.09E-01 3.03E-01

0.76 0.73

4.07E-01 2.87E-01

0.31 0.83 0.74 2.36 2.67 0.51 0.81 0.72 0.67 1.71 0.84 1.53 0.91 1.84 1.21 1.63 1.30 1.17


1.23 1.24 1.09 1.81 3.57 1.27 0.91 0.83 0.96 1.13 0.87 0.77 0.99 1.00 1.44 1.30 1.19 1.08


0.56 1.43 3.29 0.64 0.34 1.26 1.01 3.77 2.55 1.17 1.18 1.22 1.76 1.08 0.88 1.06 1.20 1.11


1.19

2.07E-01

1.31

2.41E-01

1.21

1.70E-01

1.27 1.15 0.83 1.03 1.74

1.76E-01 3.77E-01 2.51E-03 8.47E-01 1.39E-01

1.15 1.17 0.94 1.50 1.09

3.14E-01 3.11E-01 4.21E-01 1.49E-01 4.45E-01

0.98 1.38 1.30 1.07 1.29

8.04E-01 8.89E-02 1.92E-02 6.94E-01 2.13E-01

2.04 0.58

3.28E-01 5.70E-03

6.35 2.42

1.53E-01 1.67E-01

0.99 1.01

4.35E-01 2.78E-01

0.47 1.68 0.52 0.55

5.29E-06 1.23E-02 2.91E-04 1.71E-04

1.22 0.88 1.83 1.12

3.17E-01 1.40E-01 2.18E-01 2.00E-01

0.38 0.75 0.67 0.28

6.57E-04 1.82E-02 5.59E-02 4.78E-05

MSMEG_3281 spermidine/putrescine ABC transporter ATPbinding subunit MSMEG_3282 hypothetical protein MSMEG_3283 membrane transport protein MSMEG_3284 transcriptional regulator, MarR family protein MSMEG_3285 3-isopropylmalate dehydrogenase MSMEG_3286 methyltransferase MSMEG_3287 hydrolase, alpha/beta fold family protein MSMEG_3288 LysM domain protein MSMEG_3289 gp61 protein MSMEG_3290 regulatory protein MSMEG_3291 hypothetical protein MSMEG_3292 DNA-binding protein MSMEG_3293 hypothetical protein MSMEG_3294 hypothetical protein MSMEG_3295 hypothetical protein MSMEG_3296 ECF-family protein sigma factor H MSMEG_3297 transcriptional regulator, CadC MSMEG_3298 response regulator receiver domain protein MSMEG_3299 putative oxidoreductase; this gene contains a frame shift which is not the result of sequencing error MSMEG_3300 oxidoreductase, Gfo/Idh/MocA family protein MSMEG_3301 conserved hypothetical protein MSMEG_3302 short-chain dehydrogenase/reductase SDR MSMEG_3303 carboxylic ester hydrolase MSMEG_3304 succinate semialdehyde dehydrogenase MSMEG_3305 integral membrane protein DUF6 MSMEG_3306 zinc-binding alcohol dehydrogenase MSMEG_3307 methyltransferase FkbM; this gene contains a frame shift which is not the result of sequencing error MSMEG_3307 methyltransferase FkbM; this gene contains a frame shift which is not the result of sequencing error MSMEG_3308 universal stress protein family protein, putative MSMEG_3309 conserved hypothetical protein MSMEG_3310 integral membrane protein

0.76 1.17 0.99 1.03 0.85 0.93 1.07 12.40 1.17 1.50 1.05 0.87 1.29 1.05 0.89 1.01 0.73 0.37


1.07 1.86 0.89 0.89 0.89 0.97 1.09 0.69 1.67 1.37 1.20 1.23 0.87 1.28 1.10 0.99 0.97 1.31


0.32 1.00 1.48 0.93 1.60 1.79 1.08 1.13 0.60 1.56 1.01 0.88 0.91 12.45 1.36 1.04 0.38 0.69


0.35 0.53 0.55 0.64 0.82 1.15 1.10 0.81

5.08E-05 1.39E-02 2.15E-02 2.48E-02 1.59E-01 6.17E-01 2.81E-01 1.63E-01

1.65 1.19 0.96 1.05 1.02 2.54 1.41 1.21

5.79E-02 9.10E-02 7.63E-01 8.19E-01 8.41E-01 5.84E-02 3.13E-01 3.64E-01

0.77 0.80 0.84 0.85 1.10 2.21 1.07 1.28

2.66E-01 1.39E-01 1.47E-01 3.15E-01 5.33E-01 3.59E-01 2.66E-01 3.73E-01

1.83

6.76E-02

0.85

1.81E-01

1.53

1.41E-02

1.30 0.66 0.60 1.42

2.50E-01 8.31E-03 1.63E-04 2.87E-01

1.09 1.26 1.10 1.18

1.92E-01 3.24E-02 2.02E-01 1.02E-01

0.98 1.13 0.80 1.12

7.51E-01 8.09E-01 3.80E-01 1.28E-01

MSMEG_3311 acyl carrier protein MSMEG_3312 hemerythrin HHE cation binding domain subfamily protein, putative MSMEG_3313 xylose repressor, putative MSMEG_3314 transport protein MSMEG_3315 hypothetical protein MSMEG_3316 transporter, major facilitator family protein MSMEG_3317 dihydrodipicolinate reductase, N-terminus dapB domain protein MSMEG_3318 oxidoreductase MSMEG_3319 repressor protein MSMEG_3320 LysR-family transcriptional regulator; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00126 MSMEG_3321 ATP/GTP-binding protein MSMEG_3322 hypothetical protein MSMEG_3323 conserved hypothetical protein MSMEG_3324 hypothetical protein MSMEG_3325 conserved hypothetical protein MSMEG_3326 carboxylate-amine ligase MSMEG_3327 hypothetical protein MSMEG_3328 hypothetical protein MSMEG_3329 hypothetical protein MSMEG_3330 conserved domain protein MSMEG_3331 hypothetical protein MSMEG_3332 transcriptional regulator, TetR family protein MSMEG_3333 putative fatty acid desaturase, authentic frameshift; this gene contains a frame shift which is not the result of sequencing error MSMEG_3334 hypothetical protein MSMEG_3335 transcriptional regulator, IclR family protein, putative MSMEG_3336 hydrolase MSMEG_3337 hypothetical protein MSMEG_3338 oxidoreductase, FAD/FMN-binding MSMEG_3339 hypothetical protein MSMEG_3340 hypothetical protein

1.71

1.80E-01

2.30

2.15E-02

0.52

6.15E-02

1.17 1.07 1.06 3.24 0.88

3.50E-01 3.74E-01 5.90E-01 2.97E-03 5.92E-01

1.26 1.02 1.17 0.80 1.13

7.81E-02 6.18E-01 3.88E-01 1.02E-01 1.37E-01

1.19 1.49 1.02 1.14 0.93

1.74E-01 5.38E-02 6.21E-01 5.16E-02 2.69E-01

2.74 0.85 1.14

4.06E-02 1.15E-01 5.21E-01

0.86 1.03 0.87

1.95E-01 6.63E-01 1.71E-01

0.87 1.12 1.12

4.50E-01 1.62E-01 1.46E-01

0.57 2.78 1.47 0.96 1.67 4.36 4.35 5.70 3.35 3.83 17.48 22.44 1.37

6.31E-03 5.77E-03 3.24E-01 5.62E-01 6.13E-02 1.50E-02 5.72E-03 5.36E-03 3.86E-03 1.05E-02 8.27E-03 1.01E-02 9.55E-02

1.09 0.84 0.94 0.99 1.22 0.76 0.82 0.74 0.69 0.73 0.83 0.69 0.83

5.10E-01 2.47E-01 5.04E-01 7.57E-01 4.45E-02 6.74E-02 3.68E-01 5.95E-02 3.12E-02 1.28E-01 3.88E-01 5.59E-02 8.43E-02

2.28 1.47 1.35 1.78 1.04 1.09 3.07 1.81 1.56 1.22 1.47 1.48 0.98

5.87E-02 2.99E-01 3.30E-01 4.94E-02 5.80E-01 2.02E-01 1.49E-03 4.72E-02 4.24E-02 2.43E-01 1.10E-01 2.01E-01 9.38E-01

1.18 1.55

5.87E-03 9.53E-02

1.08 0.99

5.20E-01 8.73E-01

2.34 1.11

5.81E-02 4.79E-01

1.56 0.67 0.92 1.32 1.16 1.87

5.57E-02 6.06E-03 3.11E-01 4.06E-02 4.63E-01 1.02E-01

0.83 0.91 1.02 1.04 0.97 0.90

2.03E-02 6.03E-02 8.20E-01 7.84E-01 7.94E-01 7.11E-02

0.97 1.00 0.92 1.07 1.05 1.00

9.04E-01 9.86E-01 3.09E-01 8.03E-01 6.26E-01 6.56E-01


Transposase IS116/IS110/IS902 family protein hypothetical protein hypothetical protein hypothetical protein transcriptional regulator, GntR family protein putative hydroxyacid aldolase nitrilase/cyanide hydratase and apolipoprotein Nacyltransferase bacterial extracellular solute-binding protein, family protein 7 trap dicarboxylate transporter, dctq subunit, putative TRAP transporter, DctM-like membrane protein hypothetical protein hypothetical protein hypothetical protein TetR family protein transcriptional regulatory protein conserved hypothetical protein conserved hypothetical protein TIGR00026 metal-dependent phosphohydrolase, HD subdomain YaeQ protein cis-3-chloroacrylic acid dehalogenase, putative transcriptional regulator, putative conserved hypothetical protein enoyl-CoA hydratase regulatory protein, TetR RhtB family protein transporter transcriptional regulator, AraC family protein isonitrile hydratase, putative short-chain dehydrogenase/reductase SDR hypothetical protein putative transport protein hypothetical protein

0.84 1.58 1.45 2.21 1.01 0.97

1.27E-01 7.61E-02 8.03E-02 2.77E-02 9.34E-01 7.14E-01

1.55 1.04 0.83 0.92 0.96 1.03

1.61E-01 8.17E-01 2.87E-01 6.36E-01 5.99E-01 4.17E-01

0.96 0.59 1.04 0.87 1.03 0.99

7.85E-01 1.93E-02 8.02E-01 1.63E-01 7.95E-01 9.30E-01

0.65

1.26E-01

1.07

3.13E-01

0.88

1.23E-01

0.56

3.11E-02

1.18

2.35E-01

4.17

3.72E-01

0.66 0.50 0.81 1.86 1.53

8.54E-03 7.27E-04 3.55E-01 3.91E-03 2.35E-03

1.02 1.11 1.82 0.69 0.83

9.08E-01 5.08E-01 1.52E-01 3.21E-03 1.18E-01

1.07 1.04 1.01 1.30 0.93

6.91E-01 2.37E-01 7.86E-01 2.98E-01 4.22E-01

1.24 0.92 1.69

1.33E-01 5.99E-01 8.21E-02

1.24 1.13 1.01

7.70E-02 3.76E-01 9.62E-01

1.33 0.93 0.84

2.28E-01 2.41E-01 1.78E-01

0.44 0.48 0.60 0.83 1.33 1.53 0.46 0.28 0.56 1.02 0.95 1.08 1.09 1.09

2.36E-03 5.29E-05 1.79E-02 6.93E-02 2.20E-01 4.13E-02 6.27E-04 1.26E-05 4.50E-02 8.32E-01 1.94E-01 5.52E-01 7.16E-01 2.21E-01

1.17 1.04 0.92 1.04 1.16 1.46 1.00 0.91 1.55 0.89 1.05 1.60 1.48 1.05

7.32E-02 2.51E-01 2.01E-01 5.73E-01 4.37E-01 1.34E-01 9.99E-01 1.70E-01 2.69E-01 1.91E-01 3.90E-01 1.74E-02 2.54E-01 5.46E-01

0.84 1.13 1.46 0.98 0.74 0.98 1.18 1.22 1.11 1.11 1.15 1.42 1.04 1.04

4.06E-01 4.70E-01 2.35E-01 9.27E-01 1.74E-01 7.74E-01 4.72E-01 5.44E-02 4.16E-01 4.41E-01 9.71E-02 1.81E-01 7.48E-01 5.13E-01

MSMEG_3371 short-chain dehydrogenase/reductase SDR; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error; identified by match to protein family HMM PF00106 MSMEG_3372 transcriptional regulator, ArsR family protein MSMEG_3373 major facilitator superfamily protein MFS_1 MSMEG_3374 conserved hypothetical protein MSMEG_3375 alcohol dehydrogenase MSMEG_3376 beta-lactamase MSMEG_3377 hypothetical protein MSMEG_3378 beta-lactamase MSMEG_3379 2-deoxy-D-gluconate 3-dehydrogenase MSMEG_3380 pyridoxamine 5'-phosphate oxidase-related, FMNbinding MSMEG_3381 acyl carrier protein phosphodiesterase MSMEG_3382 transcriptional regulator, ArsR family protein MSMEG_3383 hypothetical protein MSMEG_3384 isoflavone reductase MSMEG_3385 hypothetical protein MSMEG_3386 shikimate transporter MSMEG_3387 aldehyde dehydrogenase (NAD) family protein MSMEG_3388 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase MSMEG_3389 putative acetolactate synthase MSMEG_3390 enoyl-CoA hydratase MSMEG_3391 L-carnitine dehydratase/bile acid-inducible protein F MSMEG_3392 acyl-CoA dehydrogenase domain protein MSMEG_3393 putative acyl-CoA dehydrogenase MSMEG_3394 cupin domain protein MSMEG_3395 short chain dehydrogenase MSMEG_3396 transcriptional regulator, IclR family protein MSMEG_3397 acetylornithine deacetylase MSMEG_3398 integral membrane transport protein MSMEG_3399 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error

0.86 2.46 0.87 2.18 0.54 1.54 0.86 0.83 0.64

6.73E-02 2.44E-04 3.56E-01 6.42E-02 1.80E-03 2.51E-03 7.21E-02 1.06E-01 4.62E-02

1.06 0.96 1.26 1.19 1.19 0.96 1.34 2.34 1.20

4.01E-01 5.99E-01 5.14E-01 3.68E-01 2.13E-01 6.24E-01 5.13E-01 9.41E-02 2.86E-01

0.83 0.94 1.15 0.74 1.18 1.08 1.36 1.03 1.01

5.66E-02 5.62E-01 3.06E-01 2.07E-01 4.20E-01 2.69E-01 2.86E-01 7.52E-02 9.17E-01

1.44 0.52 0.84 1.49 1.50 1.14 1.72 1.59

2.84E-02 9.51E-05 2.08E-01 6.57E-04 1.52E-02 6.69E-01 5.93E-02 1.39E-01

1.18 1.68 1.00 1.56 2.35 2.02 4.16 5.46

3.50E-01 6.62E-02 9.86E-01 1.66E-01 1.66E-01 2.46E-01 1.32E-01 1.84E-01

0.73 0.86 1.13 1.24 0.92 0.84 1.11 0.95

5.06E-02 4.04E-01 4.73E-01 4.61E-01 1.87E-01 1.79E-01 3.51E-01 5.00E-01

1.16 2.16 1.42

5.16E-01 2.51E-02 7.50E-02

4.54 1.00 0.89

1.75E-01 9.89E-01 1.81E-01

0.81 0.95 0.79

1.21E-01 2.78E-01 4.00E-02

1.50 1.50 1.82 2.20 2.26 0.84 0.98 0.94

4.79E-02 4.40E-04 4.59E-03 2.77E-04 1.10E-03 2.13E-02 9.06E-01 7.18E-01

1.42 1.03 0.91 1.10 0.90 1.15 1.30 1.39

4.06E-02 7.38E-01 1.86E-01 6.12E-02 1.43E-01 2.07E-01 1.65E-01 9.20E-02

0.87 1.07 0.37 0.32 0.38 1.38 0.88 1.06

1.47E-01 4.73E-01 3.25E-03 1.31E-04 1.34E-05 1.85E-01 2.20E-01 2.66E-01

0.41

1.81E-03

1.28

2.53E-02

0.60

2.04E-02

MSMEG_3399 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_3400 glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_3401 LamB/YcsF family protein MSMEG_3402 cytosine permease, putative MSMEG_3403 formamidase MSMEG_3404 HNH endonuclease domain protein MSMEG_3405 methylenomycin A resistance protein MSMEG_3406 putative transcriptional regulator, TetR family protein MSMEG_3407 epoxide hydrolase MSMEG_3408 conserved hypothetical protein MSMEG_3409 oxidoreductase MSMEG_3410 transcriptional regulator, TetR family protein MSMEG_3411 MOSC domain protein MSMEG_3412 polysaccharide deacetylase family protein MSMEG_3413 MerR-family transcriptional regulator; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00376 MSMEG_3413 MerR-family transcriptional regulator; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00376 MSMEG_3414 conserved hypothetical protein MSMEG_3415 MarR-family protein regulatory protein MSMEG_3416 protein of unknown function DUF6, transmembrane, putative MSMEG_3417 conserved hypothetical protein MSMEG_3418 conserved hypothetical protein MSMEG_3419 hypothetical protein MSMEG_3420 gluconate 5-dehydrogenase MSMEG_3421 inner membrane metabolite transport protein YdfJ MSMEG_3422 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding MSMEG_3423 probable IclR family protein regulator MSMEG_3424 transcriptional regulator, MerR family protein

0.65 0.43 0.26 0.23 0.43 0.51 0.69

7.41E-03 8.84E-03 2.78E-04 4.89E-05 6.38E-03 1.41E-03 9.57E-03

0.99 1.04 0.96 1.15 0.95 0.91 5.30

9.62E-01 7.16E-01 8.19E-01 5.96E-01 7.71E-01 1.40E-01 1.56E-01

2.26 1.07 0.89 0.90 1.01 0.96 1.15

4.47E-01 6.80E-01 4.58E-01 3.12E-01 7.36E-01 2.40E-01 4.32E-01

1.15 1.35 1.43 1.03 1.43 1.09 0.96

6.40E-01 9.45E-02 2.95E-02 7.17E-01 1.41E-01 5.41E-02 3.96E-01

1.08 2.45 0.92 4.47 7.71 0.76 1.60

6.55E-01 1.09E-01 4.86E-01 1.05E-01 1.21E-01 5.13E-02 1.10E-01

1.15 0.98 1.74 1.19 0.96 1.08 1.07

4.89E-01 7.61E-01 4.51E-03 3.79E-01 4.56E-01 7.52E-02 4.67E-01

2.89

1.00E-03

0.75

1.21E-01

0.84

1.20E-03

1.81 0.92 0.84

1.19E-02 7.90E-01 1.09E-01

0.81 2.50 1.19

2.36E-01 2.20E-01 8.10E-02

1.17 1.28 0.90

1.83E-01 4.13E-01 3.11E-01

1.19 1.09 1.44 2.47 1.00 1.19

3.12E-01 6.21E-01 2.84E-01 2.06E-01 9.77E-01 1.04E-01

1.29 1.33 2.01 1.75 1.47 1.33

3.47E-01 2.15E-02 1.20E-01 4.70E-02 9.88E-02 2.34E-01

1.32 0.79 0.89 1.02 0.85 0.79

2.64E-01 1.73E-01 6.03E-01 9.26E-01 2.33E-01 1.60E-01

1.09 1.90 0.82

4.16E-01 4.33E-01 3.22E-01

0.94 0.86 1.11

2.90E-01 3.45E-02 3.74E-01

0.83 1.16 8.03

9.89E-02 4.93E-01 3.09E-01


TetR-family protein transcriptional regulator short chain dehydrogenase metal dependent hydrolase conserved hypothetical protein O-acyl transferase SAM-dependent methyltransferase choline dehydrogenase choline dehydrogenase peptidyl-prolyl cis-trans isomerase, fkbp-type domain protein conserved hypothetical protein conserved hypothetical protein putative esterase family protein hypothetical protein hypothetical protein L-serine ammonia-lyase hypothetical protein cyclohexadienyl dehydratase hypothetical protein choline dehydrogenase 5,10-methylenetetrahydromethanopterin hypothetical protein two-component system response regulator two-component system sensor kinase DNA-binding protein haloacid dehalogenase, type II short-chain dehydrogenase/reductase TetR family protein transcriptional regulator hypothetical protein hypothetical protein heat shock protein 15 hydroxylaminobenzene mutase DoxD family protein/pyridine nucleotidedisulfide oxidoreductase conserved hypothetical protein conserved hypothetical protein ferric uptake regulation protein catalase/peroxidase HPI

sdaA

dehII

hslR

katG

1.62 1.82 1.40 1.32 2.04 0.50 1.09 1.16

3.01E-02 1.02E-01 1.50E-01 5.16E-02 9.92E-04 9.74E-04 3.31E-01 3.60E-01

1.45 1.25 1.00 1.11 1.05 0.85 2.80 7.38

2.81E-01 3.71E-01 9.70E-01 4.05E-01 6.24E-01 2.31E-01 8.13E-02 1.19E-01

1.18 0.83 1.20 1.49 0.27 1.07 1.15 1.03

1.97E-01 3.94E-01 3.96E-01 2.20E-01 3.87E-06 8.13E-01 4.97E-01 5.03E-01

0.35 0.91 0.76 1.63 1.19 1.91 1.41 1.48 1.33 1.33 1.09 2.00 1.76 1.76 1.19 1.93 2.40 1.10 1.33 1.19 1.73 1.59 1.37


1.02 0.80 0.80 2.11 3.84 2.63 0.91 1.27 1.17 1.72 12.62 1.37 1.29 6.74 1.31 1.02 1.50 0.82 2.32 0.63 0.66 0.70 1.03


1.72 0.68 0.98 0.62 0.92 0.62 0.89 1.06 1.16 0.76 1.01 0.87 1.58 1.29 0.99 0.84 2.95 0.83 0.92 1.21 0.72 0.90 1.03


1.02 1.01 1.01 8.12 5.89

7.94E-01 9.57E-01 8.89E-01 1.01E-03 2.70E-03

0.96 0.96 1.07 1.62 1.14

6.18E-01 5.22E-01 1.83E-01 2.83E-02 3.80E-01

0.87 0.95 2.27 0.47 0.69

2.41E-01 2.84E-01 1.17E-01 7.69E-04 1.56E-01


oxidoreductase putative esterase alcohol dehydrogenase acyl-CoA synthase hypothetical protein conserved hypothetical protein AMP-binding enzyme TetR family protein transcriptional regulator NAD-dependent epimerase/dehydratase GTP cyclohydrolase conserved hypothetical protein uracil phosphoribosyltransferase probable conserved integral membrane protein conserved hypothetical protein peptidase, M48 family protein possible inv protein tena/thi-4 family protein thiol peroxidase streptomycin 6-kinase (Streptidine kinase) (Streptomycin6-phosphotransferase) (APH(6)) O-succinylbenzoate synthase hypothetical protein mosc domain protein cupin domain protein putative ECF sigma factor RpoE1 catalase KatA metal-dependent phosphohydrolase transcriptional regulator, AraC family protein conserved hypothetical protein, putative putative membrane acyltransferase conserved hypothetical protein phosphodiesterase putative secreted protein putative secreted protein MmpS5 protein MmpL4 protein transcriptional regulator, ArsR family protein hypothetical protein

upp

katA

1.77 1.65 2.22 0.60 1.09 0.89 1.27 0.64 1.41 2.07 1.50 1.58 1.35 0.94 1.15 1.96 0.83 1.20


1.16 1.05 0.92 0.77 1.44 0.90 1.00 0.99 36.64 8.96 9.02 7.25 9.94 0.94 0.93 0.69 2.14 0.93


1.35 0.79 0.47 5.13 0.97 1.21 1.10 1.25 1.02 1.06 1.01 1.11 1.03 1.07 1.26 2.27 0.85 0.71


0.76 1.18 1.64 0.58 0.93 1.49 1.16 1.82 0.93 1.74 0.70 1.45 0.83 1.05 1.79 0.90 0.66 1.20 6.14


3.26 1.00 1.10 1.59 1.38 1.02 0.94 0.92 1.71 0.72 0.83 0.79 2.59 0.84 0.79 0.83 0.92 1.21 0.87


2.38 1.13 0.89 0.83 1.18 0.90 1.09 1.28 1.15 1.08 4.42 0.70 1.96 0.62 0.38 1.37 2.17 0.86 0.99




conserved hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein probable membrane protein 6-aminohexanoate-cyclic-dimer hydrolase putative amino acid decarboxylase, Pyridoxaldependent protein fructose-bisphosphate aldolase class-I hydrolase, alpha/beta hydrolase fold family protein conserved hypothetical protein hydroxylase competence damage-inducible protein A enhanced intracellular survival protein hypothetical protein 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01113 HAD-superfamily protein subfamily protein IB hydrolase conserved hypothetical protein oxidoreductase, 2-nitropropane dioxygenase family protein TetR-family protein transcriptional regulator molybdopterin oxidoreductase dopamine receptor D4 probable membrane protein linalool 8-monooxygenase transcriptional regulator, XRE family protein conserved hypothetical protein putative HTH-type transcriptional regulator ErfK/YbiS/YcfS/YnhG family protein fatty acid hydroxylase

0.49 0.43 1.70 1.81 0.61 0.19 0.49

3.98E-03 6.54E-05 5.08E-05 4.63E-02 7.50E-04 2.41E-07 1.89E-04

0.70 0.94 0.89 1.09 0.91 1.64 1.13

2.98E-03 5.23E-01 4.05E-01 3.93E-01 5.74E-01 9.04E-03 6.20E-02

0.75 1.91 0.72 2.58 1.06 0.39 0.95

1.50E-03 1.53E-01 2.90E-04 1.97E-01 8.59E-01 1.18E-03 5.42E-01

0.68 0.83

4.16E-02 1.65E-02

1.10 0.78

5.87E-02 2.36E-02

1.39 0.43

1.11E-02 1.21E-04

0.86 1.16 5.99 0.55 0.74 1.16

4.36E-02 2.72E-01 2.78E-02 3.85E-03 2.30E-02 9.02E-02

0.91 0.99 0.42 0.88 0.92 1.14

5.92E-01 8.85E-01 3.22E-02 1.20E-01 4.54E-01 3.43E-01

0.96 0.96 0.86 1.72 1.82 1.16

8.54E-01 6.49E-01 5.47E-01 3.54E-01 1.17E-01 8.42E-02

1.20

2.94E-01

1.09

4.24E-01

0.77

1.35E-01

1.48

3.26E-02

1.38

7.53E-02

0.82

1.44E-01

1.05 1.92

2.51E-01 7.32E-02

0.85 1.49

1.34E-02 7.72E-02

1.06 1.20

4.28E-01 4.60E-01

1.03 2.14 1.63 1.91 1.60 3.56 1.98 0.97 1.21 1.21 0.74

5.90E-01 5.91E-04 4.66E-03 9.37E-03 4.36E-02 1.58E-02 1.50E-03 8.68E-01 2.44E-02 1.12E-01 5.59E-02

1.10 0.82 0.86 1.15 1.09 1.25 0.83 11.30 1.56 0.57 0.90

4.41E-01 1.06E-01 1.41E-02 1.06E-01 3.98E-01 4.51E-01 1.06E-01 2.56E-01 1.69E-01 3.55E-03 7.98E-02

0.86 0.69 0.80 0.49 1.16 0.84 1.11 1.08 0.85 1.34 1.19

5.20E-01 2.06E-02 1.48E-01 5.05E-04 5.00E-01 9.25E-02 5.05E-01 5.98E-01 1.20E-01 2.54E-01 6.71E-01


conserved hypothetical protein conserved hypothetical protein serine/threonine dehydratase family protein Di-/tripeptide transporter 4-hydroxybenzoyl-CoA thioesterase agmatinase sugar transport protein hypothetical protein cyclopropane-fatty-acyl-phospholipid synthase 1 hypothetical protein conserved hypothetical protein cytochrome C biogenesis protein transmembrane region conserved hypothetical protein soluble secreted antigen MPT53 conserved hypothetical protein hypothetical protein conserved hypothetical protein ectoine/hydroxyectoine ABC transporter solutebinding protein ectoine/hydroxyectoine ABC transporter, permease protein EhuC ectoine/hydroxyectoine ABC transporter, permease protein EhuD ectoine/hydroxyectoine ABC transporter, ATPbinding protein linalool 8-monooxygenase conserved hypothetical protein dihydropyrimidinase N5,N10-methylenetetrahydromethanopterin reductase hydrolase integral membrane transporter amino acid permease-associated region carboxymethylenebutenolidase short chain dehydrogenase conserved hypothetical protein glutamine synthetase, catalytic domain

1.27 0.37 0.66 1.10 0.73 1.72 1.32 1.00 1.46 1.07 5.68

2.99E-01 3.64E-07 6.43E-03 1.47E-01 8.48E-03 4.78E-02 3.28E-01 9.75E-01 1.22E-02 6.40E-02 5.34E-04

1.19 0.89 1.15 1.70 0.98 1.13 1.78 1.13 0.78 0.61 1.07

4.64E-01 9.95E-02 1.38E-01 3.70E-01 6.72E-01 2.12E-01 5.19E-02 5.07E-01 1.65E-02 4.03E-02 6.93E-01

1.13 4.89 1.26 2.02 1.04 0.74 0.62 0.84 0.62 2.23 1.07

1.34E-01 1.72E-02 1.98E-01 3.65E-01 8.61E-01 1.47E-01 3.56E-02 1.88E-01 2.19E-03 3.56E-02 6.56E-01

1.11 4.91 2.60 2.06 1.71 0.90

5.95E-01 3.12E-03 1.65E-01 5.02E-03 4.11E-03 3.12E-01

1.87 0.94 1.60 0.48 0.45 1.01

6.68E-02 7.39E-01 7.14E-02 1.52E-03 1.15E-03 8.33E-01

0.98 1.25 0.75 2.46 3.96 1.47

7.12E-01 7.30E-02 3.12E-01 1.06E-02 8.48E-03 2.31E-01

ehuB

1.33

1.26E-01

1.04

7.58E-01

1.04

3.83E-01

ehuC

1.41

1.66E-01

0.98

5.95E-01

0.94

2.39E-01

ehuD

1.50

1.57E-01

1.23

3.28E-01

1.10

2.71E-02

ehuA hydA

1.52 1.36 0.81 1.70

3.20E-01 5.13E-02 2.26E-02 1.04E-01

1.05 0.96 1.00 0.90

5.81E-01 6.12E-01 9.64E-01 1.06E-01

1.01 1.44 1.03 1.04

1.64E-01 5.80E-02 8.45E-01 6.96E-01

glnA

2.87 3.32 2.02 1.09 3.86 3.45 1.89 2.54

1.32E-01 2.10E-02 1.50E-01 5.07E-01 2.47E-03 1.80E-02 1.29E-02 1.01E-02

0.75 0.69 0.69 1.10 1.40 1.17 1.19 0.80

1.30E-01 3.18E-02 3.29E-02 4.21E-01 1.30E-01 2.32E-01 3.46E-01 1.33E-01

1.18 0.95 0.98 1.27 0.60 0.72 0.89 0.88

6.01E-01 3.38E-01 5.52E-01 2.16E-02 6.16E-04 7.51E-02 3.56E-01 1.84E-01

speB

MSMEG_3562 4-carboxymuconolactone decarboxylase domain pcaC protein MSMEG_3563 drug transporter bfr MSMEG_3564 bacterioferritin MSMEG_3565 hypothetical protein MSMEG_3566 FadD16 protein MSMEG_3567 enoyl-CoA hydratase MSMEG_3568 conserved hypothetical protein MSMEG_3569 conserved hypothetical protein MSMEG_3570 conserved hypothetical protein MSMEG_3571 thioesterase family protein MSMEG_3572 transcriptional regulator, TetR family protein MSMEG_3573 integral membrane protein, putative MSMEG_3574 TPR domain protein MSMEG_3575 cytidine/deoxycytidylate deaminase, zinc-binding region MSMEG_3576 alpha-amylase 3 MSMEG_3577 calpastatin MSMEG_3578 putative cyclase MSMEG_3579 probable conserved transmembrane protein MSMEG_3580 antigen 85-C MSMEG_3581 FabG protein lon MSMEG_3582 ATP-dependent protease La MSMEG_3583 monooxygenase MSMEG_3584 membrane protein, MmpL family protein MSMEG_3585 MmpS2 protein MSMEG_3586 major facilitator family protein transporter MSMEG_3587 D-serine/D-alanine/glycine transporter MSMEG_3588 hypothetical protein MSMEG_3589 conserved hypothetical protein MSMEG_3590 conserved hypothetical protein MSMEG_3591 conserved hypothetical protein MSMEG_3592 hypothetical protein MSMEG_3593 conserved hypothetical protein MSMEG_3594 anthranilate dioxygenase reductase MSMEG_3595 conserved hypothetical protein MSMEG_3596 ATPase MSMEG_3596 ATPase

4.42 0.89 3.15 2.10 0.71 0.66 0.75 0.39 1.08 1.57 0.72 0.82 1.83

5.13E-04 3.64E-01 1.47E-03 7.00E-02 1.70E-03 7.06E-03 5.24E-02 1.79E-04 2.91E-01 2.16E-02 1.39E-02 9.61E-02 1.90E-03

0.97 1.12 1.19 0.90 1.03 1.02 0.96 0.90 0.98 1.05 0.94 1.15 0.80

7.22E-01 4.82E-01 3.53E-01 8.53E-02 7.67E-01 8.58E-01 7.06E-01 3.68E-01 8.74E-01 4.82E-01 6.95E-01 5.34E-01 4.61E-02

0.44 0.98 1.09 2.03 0.46 1.72 0.85 1.52 2.15 0.96 3.42 1.04 0.68

3.07E-04 8.74E-01 7.89E-01 3.43E-01 4.61E-04 8.80E-02 1.48E-01 1.69E-01 3.38E-02 5.95E-01 2.51E-01 5.55E-01 4.67E-03

1.24 0.98 3.70 1.16 1.28 0.96 2.83 7.33 3.88 1.15 1.06 1.45 0.96 1.11 1.45 1.15 1.15 0.54 0.49 2.83 1.13 0.69 1.13


1.04 1.01 1.27 1.24 0.80 0.60 1.43 3.83 5.87 1.15 1.42 1.14 3.22 2.35 2.69 2.20 1.96 1.98 2.80 1.02 1.00 1.45 1.11


1.52 1.40 0.63 0.73 0.92 1.06 0.85 0.93 1.07 0.76 1.04 3.98 1.03 1.01 0.92 0.89 0.92 1.66 1.19 1.37 1.42 1.61 2.19


MSMEG_3598 periplasmic sugar-binding proteins MSMEG_3599 sugar-binding transcriptional regulator, LacI family protein MSMEG_3600 hypothetical protein MSMEG_3601 ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components MSMEG_3602 ribose transport ATP-binding protein RbsA MSMEG_3603 oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_3604 sorbitol utilization protein SOU2 MSMEG_3605 sorbitol dehydrogenase MSMEG_3606 transcriptional regulator MSMEG_3607 short chain dehydrogenase MSMEG_3608 acetyl-CoA acetyltransferase MSMEG_3609 hydride transferase 1 MSMEG_3610 conserved hypothetical protein MSMEG_3611 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase MSMEG_3612 probable conserved integral membrane protein MSMEG_3613 conserved hypothetical protein MSMEG_3614 hypothetical protein MSMEG_3615 zinc-binding alcohol dehydrogenase family protein MSMEG_3616 integral membrane protein MSMEG_3617 hypothetical protein MSMEG_3618 alanine and proline-rich secreted protein apa MSMEG_3619 short chain dehydrogenase MSMEG_3620 conserved hypothetical protein MSMEG_3621 NADH dehydrogenase MSMEG_3622 conserved hypothetical protein MSMEG_3623 urease accessory protein UreG MSMEG_3624 urease accessory protein uref MSMEG_3625 urease, alpha subunit MSMEG_3626 urease, beta subunit MSMEG_3627 urease, gamma subunit MSMEG_3628 ComA operon protein 2 MSMEG_3629 conserved hypothetical protein MSMEG_3630 transcriptional repressor, CopY family protein

xfp

ndh ureG ureC ureB ureA

1.38

2.84E-04

0.98

8.89E-01

2.61

4.61E-01

1.74 0.81

9.61E-04 5.04E-04

0.96 0.89

6.86E-01 1.36E-02

0.48 0.89

3.96E-05 1.84E-01

1.33 1.17

5.81E-02 1.86E-01

0.94 1.03

6.52E-01 7.19E-01

1.26 1.04

5.44E-01 7.07E-01

1.25 1.72 1.78 1.62 1.10 0.51 1.03 0.96

2.00E-02 6.04E-03 4.91E-04 4.66E-02 5.62E-01 1.81E-03 7.15E-01 7.15E-01

0.98 0.89 0.88 1.08 1.13 1.06 0.84 1.35

8.79E-01 3.41E-01 2.40E-01 2.14E-01 2.88E-01 2.67E-01 1.33E-02 9.49E-02

1.35 0.92 0.63 0.76 0.92 2.11 0.80 1.47

3.53E-01 2.89E-01 5.99E-03 1.08E-01 5.00E-01 1.37E-01 1.32E-01 1.80E-01

1.23 1.38 0.85 0.99

1.94E-01 2.27E-02 9.95E-02 7.61E-01

1.34 0.63 0.92 1.05

3.45E-02 1.31E-02 4.90E-01 4.33E-01

0.56 0.97 0.98 0.89

1.06E-01 8.65E-01 8.46E-01 5.79E-02

5.28 6.65 9.46 1.11 0.98 1.02 0.89 0.47 0.48 0.34 0.53 0.40 0.43 0.52 0.60 0.81


0.55 0.66 0.97 0.92 1.10 1.05 2.02 0.98 0.96 1.00 0.92 1.04 0.99 0.96 1.34 0.93


2.17 2.29 2.26 0.72 1.43 0.89 2.23 1.37 0.83 1.02 0.74 1.26 0.99 2.82 1.84 4.82


MSMEG_3631 integral membrane protein MSMEG_3632 6-phosphogluconate dehydrogenase, decarboxylating MSMEG_3633 ferric cations import ATP-binding protein FbpC MSMEG_3634 IMP dehydrogenase family protein MSMEG_3635 iron(III)-transport system permease protein SfuB MSMEG_3636 ferric iron-binding periplasmic protein of ABC transporter MSMEG_3637 CBS domain protein MSMEG_3638 CBS domain protein MSMEG_3639 conserved hypothetical protein MSMEG_3640 malate synthase G MSMEG_3641 conserved hypothetical protein MSMEG_3642 glycine dehydrogenase MSMEG_3643 hypothetical protein MSMEG_3644 transcriptional regulator, MerR family protein MSMEG_3645 conserved hypothetical protein MSMEG_3646 transcriptional regulator, MerR family protein MSMEG_3647 forkhead-associated protein MSMEG_3648 glycine cleavage system H protein MSMEG_3649 conserved hypothetical protein MSMEG_3650 integral membrane protein MSMEG_3651 membrane associated protein MSMEG_3652 CDP-diacylglycerol-glycerol-3-phosphate MSMEG_3653 hypothetical protein MSMEG_3654 ATPase SecA2 MSMEG_3655 ABC transporter, permease/ATP-binding protein MSMEG_3656 ABC transporter, permease/ATP-binding protein MSMEG_3657 succinate dehydrogenase MSMEG_3658 conserved hypothetical protein MSMEG_3659 TetR-family protein transcriptional regulator MSMEG_3660 conserved hypothetical protein TIGR00026 MSMEG_3661 conserved hypothetical protein MSMEG_3662 mannose-binding lectin MSMEG_3663 oxidoreductase MSMEG_3664 transporter, monovalent cation:proton antiporter-2 (CPA2) family protein MSMEG_3665 TrkA domain protein

gnd

glcB gcvP

gcvH

1.00

9.72E-01

1.03

7.49E-01

4.37

2.58E-03

1.12 0.52 0.95 0.89

2.50E-02 5.12E-03 4.38E-01 2.00E-03

0.99 1.07 0.78 0.91

9.36E-01 5.04E-02 4.80E-02 1.40E-01

2.28 1.83 3.31 1.74

1.68E-03 8.22E-02 1.37E-03 4.59E-03

0.92 2.14 2.38 0.88 0.92 0.68 0.46 1.06 2.14 2.20 0.47 0.72 0.76 0.77 1.03 1.00 0.92 0.95 0.80 0.80 0.64 1.10 1.88 0.99 0.77 0.92 0.33 0.44


0.92 0.68 0.90 0.86 1.01 1.08 0.97 0.99 0.83 1.10 0.97 0.90 0.82 0.94 1.19 1.07 1.23 1.14 0.94 1.17 1.09 0.84 0.98 1.15 1.20 0.98 1.45 1.40


0.98 2.35 3.93 2.04 2.33 3.59 5.65 1.68 1.18 1.61 0.93 0.71 0.60 1.33 1.34 1.63 1.14 1.03 1.21 0.69 1.14 1.10 3.60 0.97 1.15 0.50 0.64 1.11


1.72 1.41

8.29E-02 9.34E-02

1.05 0.83

5.72E-01 1.71E-01

0.93 0.78

9.05E-02 4.49E-02



C-5 sterol desaturase para-nitrobenzyl esterase acyl-CoA dehydrogenase conserved hypothetical protein transporter, small multidrug resistance (SMR) family protein integral membrane protein transporter, small multidrug resistance (SMR) family protein malQ 4-alpha-glucanotransferase hypothetical protein metal-dependent hydrolase phenoxybenzoate dioxygenase beta subunit serine/threonine protein kinase hypothetical protein phosphohydrolase hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein nuclear transport factor 2 (NTF2) domain family protein conserved hypothetical protein conserved hypothetical protein medium chain acyl-CoA synthetase conserved hypothetical protein sodium:solute symporter transcriptional regulatory protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF08220 galT galactose-1-phosphate uridylyltransferase galK galactokinase cytochrome P450 monooxygenase feruloyl-CoA synthetase conserved hypothetical protein hypothetical protein conserved hypothetical protein

0.90 1.54 0.99 1.33

1.13E-01 3.18E-02 3.69E-01 3.91E-01

1.20 0.88 5.14 3.61

1.09E-01 1.31E-02 1.87E-01 1.46E-01

1.67 1.28 1.12 1.05

7.27E-02 1.70E-01 5.96E-01 2.25E-01

0.78 0.91

8.40E-02 1.92E-01

1.48 0.90

3.72E-01 3.86E-01

0.91 3.18

1.47E-01 3.06E-04

0.77 0.77 1.58 3.00 1.60 1.31 1.07 1.24 1.63 0.85 0.81 0.93

2.60E-02 1.27E-01 7.94E-03 1.12E-03 2.02E-04 3.09E-02 3.99E-01 3.86E-01 7.58E-02 9.63E-03 1.20E-01 3.49E-01

0.98 1.30 0.85 0.73 0.85 0.87 0.72 1.04 1.23 0.71 1.28 0.79

7.74E-01 4.52E-02 2.83E-01 2.39E-02 1.17E-01 3.66E-01 1.45E-02 7.31E-01 2.28E-01 8.77E-03 2.27E-01 5.52E-02

2.95 0.87 0.67 1.68 1.75 0.51 3.42 1.83 2.04 1.33 2.84 1.00

1.62E-01 2.41E-01 3.80E-03 5.67E-02 9.65E-02 5.12E-04 5.17E-03 2.85E-01 1.95E-01 1.07E-01 1.59E-01 9.88E-01

1.27 5.37 2.16 1.20 1.21 0.67

6.49E-02 1.19E-03 1.22E-03 4.83E-02 2.08E-01 6.46E-03

0.88 0.84 0.79 0.74 1.13 1.28

8.13E-02 2.38E-01 6.46E-02 4.07E-02 3.64E-01 8.56E-02

1.00 1.07 0.75 0.97 0.49 0.42

9.69E-01 4.22E-01 1.20E-01 6.68E-01 5.40E-04 3.58E-04

0.69 0.87 0.74 1.31 1.15 1.92 1.32 1.34

1.50E-02 2.04E-01 2.83E-01 1.02E-01 1.85E-01 5.82E-02 2.10E-01 9.00E-02

0.88 1.10 1.08 1.01 1.02 0.95 1.03 1.00

2.38E-01 6.66E-01 2.84E-01 8.77E-01 8.19E-01 7.54E-01 6.72E-01 9.47E-01

0.56 0.93 1.10 1.01 1.44 1.14 1.37 0.96

8.14E-03 1.28E-01 1.49E-01 6.34E-01 2.29E-01 4.38E-01 3.35E-01 5.96E-01


peroxidase conserved hypothetical protein hypothetical protein hypothetical protein 3-alpha-hydroxysteroid dehydrogenase major facilitator superfamily protein MFS_1 isocitrate lyase conserved hypothetical protein catalase conserved hypothetical protein cytochrome b561 family protein hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein linear gramicidin synthetase subunit C hypothetical protein short-chain dehydrogenase/reductase SDR; this gene contains a frame shift which is not the result of sequencing error short-chain dehydrogenase/reductase SDR; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein sodium/calcium exchanger protein recombination activating protein 1 coenzyme PQQ biosynthesis protein E bifunctional coenzyme PQQ synthesis protein C/D coenzyme PQQ biosynthesis protein C coenzyme PQQ biosynthesis protein B coenzyme PQQ biosynthesis protein A alcohol dehydrogenase hypothetical protein hypothetical protein catalase/peroxidase HPI helix-turn-helix, Fis-type, putative dipeptidase 2

aceA

pqqE pqqC pqqB pqqA

katG

0.97 0.97 0.68 1.19 0.39 0.25 3.75 3.71 0.60 0.82 0.83 6.49 1.10 0.69 1.34 1.07 0.86


1.23 1.09 0.61 1.25 1.00 0.86 1.31 1.11 0.80 1.69 0.88 1.34 1.01 1.16 0.94 1.10 1.10


1.12 0.97 0.89 2.06 1.01 1.12 0.20 0.93 0.41 1.13 0.57 0.95 1.14 0.99 0.87 0.84 1.15


2.44

8.61E-03

1.44

1.42E-02

0.70

5.90E-02

1.18 2.23 1.21 1.31 1.14

2.56E-01 4.45E-03 2.65E-01 3.18E-01 5.80E-01

1.06 0.80 0.75 1.00 0.88

6.14E-01 5.10E-03 8.65E-03 1.00E+00 1.11E-01

1.53 1.47 0.88 1.07 1.24

3.84E-01 5.98E-02 6.63E-01 1.15E-01 2.04E-01

1.10 1.26 1.15 1.46 1.82 1.73 1.09 2.69 5.03 1.71

5.88E-01 1.85E-01 1.39E-01 1.05E-02 9.04E-03 9.18E-02 3.14E-01 4.70E-02 2.54E-03 3.04E-01

1.04 0.82 3.06 0.62 0.81 0.91 1.05 0.90 0.92 1.25

6.93E-01 9.26E-02 3.55E-01 4.36E-02 7.83E-02 3.59E-01 6.58E-01 1.74E-01 5.44E-01 1.88E-01

0.95 1.30 1.42 1.06 2.19 1.18 0.98 1.09 0.71 9.56

2.05E-01 1.75E-01 3.56E-01 1.35E-01 2.69E-01 1.17E-01 7.68E-01 2.79E-01 8.70E-02 3.19E-01

MSMEG_3732 MSMEG_3733 MSMEG_3735 MSMEG_3736 MSMEG_3737 MSMEG_3738 MSMEG_3739 MSMEG_3740 MSMEG_3741 MSMEG_3742 MSMEG_3743 MSMEG_3744 MSMEG_3745 MSMEG_3746 MSMEG_3747 MSMEG_3748 MSMEG_3749 MSMEG_3749 MSMEG_3750 MSMEG_3751 MSMEG_3752 MSMEG_3753 MSMEG_3754 MSMEG_3758 MSMEG_3759 MSMEG_3760 MSMEG_3761 MSMEG_3762

hypothetical protein conserved hypothetical protein YtnM protein hypothetical protein integral membrane protein GTP-binding protein EngA cmk cytidylate kinase ribosomal large subunit pseudouridine synthase B rluB transcriptional regulator scpA segregation and condensation protein A soj SpoOJ regulator protein xerD tyrosine recombinase XerD MutT/nudix family protein pyrG CTP synthase conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error thiamin pyrophosphokinase, catalytic domain protein DNA repair protein RecN; this gene contains a frame shift which is not the result of sequencing error DNA repair protein RecN; this gene contains a frame shift which is not the result of sequencing error inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NADkinase) hemolysin A conserved hypothetical protein hydrolase TPR-repeat-containing protein tyrS tyrosyl-tRNA synthetase 3-methyladenine DNA glycosylase conserved hypothetical protein putative Clp protease subunit ABC transporter ATP-binding protein

0.99 1.12 0.53 0.84 0.44 1.02 1.20

9.07E-01 9.00E-02 4.00E-03 1.85E-03 3.85E-04 7.05E-01 2.70E-02

1.11 0.79 1.08 1.06 0.85 0.74 0.82

4.81E-01 3.42E-02 6.80E-01 8.13E-01 1.32E-01 3.80E-03 4.56E-02

1.00 2.62 6.23 4.66 1.70 4.33 3.84

9.48E-01 8.18E-04 6.69E-03 2.17E-03 2.72E-02 2.35E-02 1.08E-02

1.33 1.25 0.58 0.92 0.60 0.57 0.74

1.20E-02 5.29E-03 1.01E-02 2.30E-01 2.22E-03 7.74E-04 2.24E-03

0.83 0.74 1.20 0.92 1.33 1.06 0.93

3.55E-02 3.35E-02 6.83E-02 3.51E-01 2.82E-01 6.46E-01 3.19E-01

3.90 3.00 2.61 5.55 4.64 4.96 1.94

7.85E-04 4.44E-03 1.53E-02 2.06E-01 1.39E-01 5.50E-03 1.69E-02

0.92

7.87E-01

1.00

9.77E-01

1.55

5.62E-01

1.04

8.66E-01

0.80

2.45E-01

1.57

1.86E-01

0.73

4.16E-03

0.86

1.42E-01

3.17

5.13E-04

0.91

3.55E-02

0.89

2.46E-01

4.64

5.26E-03

0.74 0.76 1.12 0.57 0.39 0.53 0.67 1.13 1.02 2.04

6.48E-03 1.05E-03 2.71E-02 4.16E-05 5.72E-03 3.13E-05 1.06E-01 1.43E-01 9.19E-01 2.15E-02

0.85 0.96 0.81 0.70 1.03 1.09 1.17 1.05 0.83 0.70

4.15E-02 5.84E-01 1.50E-01 1.32E-02 8.37E-01 1.15E-01 3.69E-01 4.89E-01 4.38E-02 1.44E-01

3.25 2.36 1.77 1.10 0.98 1.24 1.18 1.19 0.91 1.21

3.94E-04 5.13E-03 6.29E-02 4.56E-01 6.71E-01 1.09E-01 3.20E-01 4.52E-01 4.58E-01 2.25E-01

MSMEG_3763 ABC transporter efflux protein, DrrB family protein MSMEG_3764 conserved hypothetical protein MSMEG_3765 transcriptional regulator MSMEG_3766 hypothetical protein MSMEG_3767 acyl-CoA synthase MSMEG_3768 macrolide-transport ATP-binding protein abc transporter MSMEG_3769 argininosuccinate lyase MSMEG_3770 argininosuccinate synthase MSMEG_3771 arginine repressor MSMEG_3772 ornithine carbamoyltransferase MSMEG_3773 acetylornithine aminotransferase MSMEG_3774 acetylglutamate kinase MSMEG_3775 arginine biosynthesis bifunctional protein ArgJ MSMEG_3776 N-acetyl-gamma-glutamyl-phosphate reductase MSMEG_3777 phenylalanyl-tRNA synthetase, beta subunit MSMEG_3778 phenylalanyl-tRNA synthetase, alpha subunit MSMEG_3779 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_3780 adenylate and Guanylate cyclase catalytic domain protein MSMEG_3781 conserved hypothetical protein MSMEG_3782 endoribonuclease L-PSP, putative MSMEG_3783 acyl-CoA dehydrogenase MSMEG_3784 transcriptional regulator, IclR family protein MSMEG_3785 PfkB-family protein carbohydrate kinase MSMEG_3786 D-amino acid deaminase MSMEG_3787 D-aminoacylase MSMEG_3788 2-dehydro-3-deoxyphosphogluconate aldolase/4hydroxy-2-oxoglutarate aldolase MSMEG_3789 inner membrane permease YgbN MSMEG_3790 RNA methyltransferase, TrmH family protein MSMEG_3791 ribosomal protein L20 MSMEG_3792 ribosomal protein L35 MSMEG_3793 translation initiation factor IF-3 MSMEG_3794 hypothetical protein

argH argG argR argF argD argB argJ argC pheT pheS

eda rplT rpmI infC

2.03 0.92 1.10 1.24 0.77

6.68E-03 2.09E-01 3.78E-01 4.00E-03 1.52E-02

0.50 0.95 0.62 0.85 0.85

2.64E-02 4.85E-01 1.37E-02 1.67E-01 1.98E-01

1.58 1.06 1.04 0.67 1.27

2.40E-01 3.87E-01 6.53E-01 1.86E-05 1.85E-01

0.68 0.54 0.80 0.62 0.62 0.78 0.84 1.04 1.16 0.38 0.42

2.27E-02 1.40E-03 2.14E-01 3.98E-03 9.73E-03 8.29E-02 1.95E-01 6.50E-01 2.63E-01 7.57E-05 2.97E-05

0.95 0.89 0.80 0.86 0.86 0.85 0.83 0.77 0.66 1.04 0.97

5.23E-01 5.71E-01 2.96E-01 4.07E-01 4.71E-01 4.11E-01 4.15E-01 2.15E-01 7.74E-02 5.61E-01 8.06E-01

1.71 1.06 0.88 2.01 1.39 1.34 0.98 1.15 1.21 1.11 1.45

6.06E-02 7.22E-01 1.73E-01 4.68E-02 6.23E-02 1.77E-01 8.74E-01 3.95E-01 5.36E-01 6.07E-01 3.52E-01

0.58

6.89E-04

0.92

2.90E-01

1.28

4.37E-01

0.93 5.78 0.92 1.06 0.82 1.43 1.22 0.95

2.68E-01 6.48E-03 2.72E-01 4.84E-01 3.43E-02 4.54E-02 2.29E-01 5.35E-01

0.94 0.69 1.04 0.90 1.01 0.97 1.02 1.15

5.63E-01 2.07E-02 5.98E-01 3.80E-01 8.65E-01 5.56E-01 4.63E-01 2.80E-01

8.16 0.71 0.95 0.94 1.01 1.18 0.92 0.99

3.60E-01 1.83E-01 5.76E-01 5.02E-01 7.27E-01 4.29E-01 5.63E-01 8.41E-01

0.83 0.92 0.34 0.68 1.09 1.90 1.86

9.54E-03 1.34E-01 2.02E-06 4.68E-05 1.31E-01 4.51E-03 3.86E-03

1.05 1.55 1.18 0.66 1.02 0.82 0.74

6.92E-01 3.09E-01 3.44E-01 1.18E-02 7.40E-01 9.66E-02 5.02E-02

1.29 1.19 2.05 0.76 1.07 0.88 1.05

1.33E-01 5.00E-01 7.12E-02 1.74E-02 5.01E-01 2.86E-01 5.50E-01


conserved hypothetical protein lysyl-tRNA synthetase putative esterase family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein tetratricopeptide repeat family protein lipoprotein LpqH conserved hypothetical protein oxidoreductase, short chain dehydrogenase/reductase family protein conserved hypothetical protein TetR-type regulator excinuclease ABC, A subunit conserved hypothetical protein hydrolase universal stress protein family protein, putative acyl-CoA thioesterase NAD-dependent epimerase/dehydratase possible drug efflux membrane protein excinuclease ABC, B subunit conserved hypothetical protein thermolabile glutaminase conserved hypothetical protein hypothetical protein amino acid permease regulatory protein GntR, HTH 3-oxoacyl-[acyl-carrier-protein] reductase conserved hypothetical protein 3-oxoacyl-[acyl-carrier-protein] reductase hypothetical protein glutamine synthetase glutamine synthetase esterase 3-oxoacyl-[acyl-carrier-protein] reductase

uvrA

uvrB

0.83 0.59 1.37 1.11 2.02 1.23 0.88 1.12 0.86 1.60

3.93E-02 1.39E-02 2.19E-02 3.94E-01 4.58E-03 3.23E-02 3.83E-01 2.56E-01 2.02E-02 3.31E-02

0.94 0.93 0.78 0.89 0.88 1.19 0.82 0.94 1.15 0.79

4.42E-01 4.05E-01 4.90E-02 4.08E-02 2.13E-01 2.51E-01 2.55E-01 2.29E-01 3.53E-01 9.36E-02

1.03 0.84 0.67 1.37 1.08 0.98 1.13 1.23 1.30 1.15

7.32E-01 1.61E-01 7.23E-02 1.56E-02 6.93E-01 8.93E-01 3.75E-01 8.37E-02 1.39E-01 4.83E-01

1.14 1.30 1.46 1.12 1.39 0.55 0.38 0.38 1.31 0.81 2.11 1.45 1.06 2.16 1.08 1.85 0.88 1.37 0.89 0.96 0.88 1.81 1.25 0.92 0.93


1.09 1.01 0.99 0.88 0.91 1.09 0.86 0.98 2.63 1.05 0.89 0.90 1.20 1.05 1.08 0.83 0.91 1.12 1.00 0.92 0.94 1.08 0.89 1.17 0.98


1.03 1.89 1.05 2.03 1.07 1.31 6.45 1.13 1.12 1.81 0.87 1.01 0.97 0.72 1.00 1.22 0.97 0.95 1.01 1.17 1.18 0.52 0.96 0.93 0.90


MSMEG_3831 dephospho-CoA kinase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01121; match to protein family HMM TIGR00152 MSMEG_3832 4-hydroxyacetophenone monooxygenase MSMEG_3833 30S ribosomal protein S1 MSMEG_3834 putative TetR-family protein transcriptional regulator MSMEG_3835 YesF protein MSMEG_3836 conserved hypothetical protein MSMEG_3837 conserved hypothetical protein MSMEG_3838 integral membrane protein MSMEG_3839 DNA polymerase I MSMEG_3840 LysR-family protein transcriptional regulator MSMEG_3841 monooxygenase, FAD-binding MSMEG_3842 putative esterase MSMEG_3843 conserved hypothetical protein MSMEG_3844 lipid-transfer protein MSMEG_3845 conserved domain protein MSMEG_3846 phosphotransferase enzyme family protein MSMEG_3847 copper methylamine oxidase MSMEG_3848 para-nitrobenzyl esterase MSMEG_3849 hypothetical protein MSMEG_3850 alkanesulfonate monooxygenase family protein MSMEG_3851 LppI protein MSMEG_3852 aliphatic sulfonate binding protein MSMEG_3853 putative aliphatic sulfonates transport ATPbinding protein SsuB MSMEG_3854 putative aliphatic sulfonates transport permease protein SsuC MSMEG_3855 hypothetical protein MSMEG_3856 transcriptional regulator, CadC MSMEG_3857 conserved hypothetical protein MSMEG_3858 conserved hypothetical protein MSMEG_3859 glycosyl transferase, group 2 family protein MSMEG_3860 polyprenol-monophosphomannose synthase Ppm1

0.25 1.20 0.87

4.19E-06 5.01E-01 2.80E-02

1.07 1.18 0.79

7.26E-01 3.21E-01 1.35E-02

0.78 1.04 0.49

2.46E-01 3.57E-01 1.99E-06

1.23 1.34 1.29 0.58 1.20 0.61 1.12 1.89 1.06 0.77 0.79 0.52 1.86 2.05 1.06 0.90 0.99 1.02 1.70


0.88 0.72 0.73 0.74 0.91 0.95 0.92 0.92 1.17 0.91 0.92 1.12 1.12 1.11 0.81 1.06 2.68 0.67 1.86


1.12 1.41 1.27 2.10 0.77 1.52 2.81 1.02 1.63 1.00 0.94 0.98 0.31 0.86 0.82 0.98 2.01 1.48 1.05


1.24

3.31E-01

2.93

2.66E-01

1.86

3.06E-01

1.23 1.18 1.48 0.95 1.51 0.91

1.75E-01 1.18E-01 8.55E-02 4.24E-01 5.38E-04 3.48E-02

1.64 1.08 0.97 1.48 1.26 0.71

2.81E-01 4.67E-01 7.65E-01 6.74E-02 1.02E-01 9.13E-03

1.38 0.48 2.88 0.82 1.40 1.99

4.17E-02 3.05E-03 3.24E-02 2.66E-01 2.85E-02 1.27E-03

0.63

1.87E-03

1.12

2.63E-01

4.84

1.64E-02


amidohydrolase 3 FxsA cytoplasmic membrane protein pyridoxamine 5'-phosphate oxidase family cobaltochelatase, CobN subunit hypothetical protein conserved hypothetical protein ATPase family protein associated with various cellular activities (AAA) conserved hypothetical protein conserved hypothetical protein alpha-ketoglutarate-dependent taurine precorrin-3B synthase precorrin-8X methylmutase cobalamin biosynthesis protein cobIJ transcriptional regulator, TetR family protein precorrin-6x reductase phosphotransferase enzyme family protein, putative precorrin-4 C11-methyltransferase precorrin-6Y C5,15-methyltransferase (decarboxylating) short chain dehydrogenase nitrilase/cyanide hydratase and apolipoprotein Nacyltransferase proline dipeptidase glyoxalase family protein 5'-3' exonuclease conserved hypothetical protein DEAD/DEAH box helicase twin arginine-targeting protein translocase TatC twin arginine-targeting protein translocase, TatA/E family protein conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error

1.09 2.27 1.05 0.83 1.41 1.62

1.37E-01 4.07E-03 3.38E-01 2.71E-01 9.42E-02 6.08E-02

1.22 0.83 0.89 0.96 0.81 0.93

3.30E-01 2.15E-02 9.03E-02 2.68E-01 5.53E-02 6.55E-01

2.17 0.79 1.07 2.53 1.38 1.45

3.40E-03 1.07E-01 3.00E-01 3.57E-02 3.11E-01 1.07E-01

cobK

2.26 2.71 2.27 1.01 1.65 0.47 0.54 2.21 0.59

3.73E-02 3.98E-04 2.81E-02 7.86E-01 1.78E-03 1.74E-04 1.45E-05 4.37E-03 8.55E-03

0.96 1.02 1.35 7.97 0.75 0.94 1.19 0.95 0.94

7.69E-01 8.56E-01 1.42E-01 2.44E-01 8.21E-03 5.37E-01 5.67E-01 7.96E-01 7.31E-01

1.49 3.05 1.29 1.74 4.40 1.58 1.70 0.80 1.34

9.91E-02 1.28E-01 3.06E-01 1.79E-01 1.93E-01 1.99E-02 1.28E-01 4.67E-01 8.61E-02

cobM

2.26 0.53

1.42E-02 2.05E-04

0.72 0.86

9.58E-02 2.38E-01

0.97 1.36

8.06E-01 4.83E-02

0.75 0.67

2.96E-02 2.26E-03

0.85 0.73

1.16E-02 2.92E-03

1.66 1.10

8.29E-02 6.61E-01

0.83 1.20 2.24 0.82 1.15 0.60 0.91

2.33E-02 3.67E-02 2.18E-03 4.94E-03 1.68E-02 5.72E-03 2.22E-01

0.98 0.85 0.79 0.83 0.81 1.03 0.81

8.41E-01 1.70E-01 5.54E-02 1.56E-01 1.18E-01 5.38E-01 8.68E-02

1.41 0.93 0.79 1.13 1.28 6.26 2.56

4.88E-03 4.72E-01 7.09E-03 5.63E-01 9.82E-02 1.69E-02 6.88E-04

2.93 0.76

1.05E-03 1.53E-02

0.75 0.86

6.77E-02 2.52E-01

1.14 1.92

5.47E-01 8.89E-04

0.73

3.69E-02

0.90

3.77E-01

2.12

8.62E-04

cobN

cobG

cobL

tatC tatA

MSMEG_3889 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_3890 proteasome component MSMEG_3891 hydrolase MSMEG_3892 hypothetical protein MSMEG_3893 hypothetical protein MSMEG_3894 proteasome alpha subunit MSMEG_3895 proteasome beta subunit MSMEG_3896 conserved hypothetical protein MSMEG_3897 proteasome component thpD MSMEG_3898 ectoine hydroxylase ectC MSMEG_3899 ectoine synthase MSMEG_3900 diaminobutyrate--2-oxoglutarate aminotransferase ectB ectA MSMEG_3901 L-2,4-diaminobutyric acid acetyltransferase MSMEG_3902 ATPase, AAA family protein MSMEG_3903 Low molecular weight antigen MTB12 MSMEG_3904 LppK protein MSMEG_3905 conserved hypothetical protein MSMEG_3906 tRNA (adenine-N(1)-)-methyltransferase MSMEG_3907 RecB family protein exonuclease MSMEG_3908 conserved hypothetical protein MSMEG_3909 conserved hypothetical protein MSMEG_3910 conserved hypothetical protein MSMEG_3911 oxidoreductase MSMEG_3912 acetoacetyl-CoA reductase MSMEG_3913 short chain dehydrogenase; this gene contains a frame shift which is not the result of sequencing error MSMEG_3914 beta-lactamase MSMEG_3915 NAD-dependent alcohol dehydrogenase MSMEG_3916 hypothetical protein MSMEG_3917 hypothetical protein MSMEG_3918 hypothetical protein MSMEG_3919 hypothetical protein MSMEG_3920 hypothetical protein MSMEG_3921 hypothetical protein MSMEG_3922 hypothetical protein

0.94 1.65 1.76 0.65 0.72 0.80 0.96 1.93 1.80 3.19 5.86 8.96 11.20 1.29 0.61 0.41 0.53 1.06 0.93 0.48 1.23 0.92 1.18 1.18


1.05 0.91 1.15 1.21 1.10 1.04 0.84 0.77 1.89 0.64 0.82 0.71 0.64 0.63 0.75 0.90 0.88 1.18 0.92 1.02 0.99 0.98 1.18 1.18


1.72 0.66 0.33 1.01 0.96 0.98 1.13 0.85 1.90 1.74 1.80 1.44 1.57 2.02 0.93 1.18 1.23 2.39 2.12 2.39 1.41 0.82 1.08 1.06


1.55 2.60 1.27 2.15 0.98 2.12 2.17 1.88 1.67 1.88

1.42E-01 1.10E-01 1.11E-01 8.04E-03 8.45E-01 9.94E-04 1.40E-03 2.65E-03 2.77E-01 1.02E-03

1.00 1.26 1.15 0.91 1.11 0.90 1.04 1.04 1.20 1.03

9.77E-01 4.39E-01 4.66E-01 6.40E-01 4.35E-02 2.68E-01 4.71E-01 7.36E-01 7.44E-02 5.80E-01

1.07 0.93 3.36 1.69 1.42 0.65 1.01 1.00 1.23 0.99

5.75E-01 4.23E-01 2.38E-01 3.84E-02 2.99E-02 9.85E-03 9.78E-01 9.84E-01 5.44E-01 5.87E-01


conserved hypothetical protein peptide synthetase ScpsB, putative AttM/AiiB family protein cation-transporting ATPase Pma1 peptidase M52, hydrogen uptake protein [NiFe] hydrogenase, alpha subunit, putative [NiFe] hydrogenase, delta subunit, putative [NiFe] hydrogenase, gamma subunit, putative [NiFe] hydrogenase, beta subunit, putative 14 kDa antigen conserved hypothetical protein phosphoenolpyruvate synthase conserved hypothetical protein universal stress protein family protein conserved hypothetical protein hypothetical protein universal stress protein family protein universal stress protein family protein GAF family protein conserved hypothetical protein conserved hypothetical protein two component transcriptional regulatory protein devr universal stress protein family protein probable conserved transmembrane protein 6-phosphofructokinase isozyme 2 acyltransferase, ws/dgat/mgat subfamily protein acyltransferase, ws/dgat/mgat subfamily protein hypothetical protein universal stress protein family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein trehalose 6-phosphate phosphorylase conserved hypothetical protein alkylhydroperoxidase AhpD conserved 13e12 repeat family protein

0.61 0.93 1.67 1.11 1.44 2.57 1.01 1.19 1.03 2.04 1.60 1.60 1.53 1.17 1.67 1.46 1.36 1.18 2.47 2.70 1.87

1.99E-03 5.79E-01 4.01E-01 7.98E-02 7.40E-02 1.35E-03 9.38E-01 8.42E-02 8.16E-01 8.89E-02 8.70E-02 3.13E-01 8.53E-02 4.42E-01 1.95E-01 3.09E-01 3.48E-02 2.41E-01 3.00E-02 3.47E-02 1.55E-01

0.93 0.91 0.92 4.70 5.19 2.20 8.20 10.00 16.74 48.74 9.88 13.83 11.26 3.58 8.83 1.37 10.86 12.02 0.99 11.94 8.09


1.14 1.11 0.97 15.13 18.65 7.58 26.95 28.04 67.26 57.70 10.07 22.71 8.08 9.85 18.94 0.94 9.21 24.01 1.51 11.87 10.04


1.04 1.76 1.50 1.50 1.28 1.50 2.04 1.91 1.18 1.36 1.19 1.27 1.61 0.44 1.34


4.18 8.79 11.97 1.90 3.17 6.19 25.78 11.62 4.31 16.15 5.76 2.28 5.68 1.70 0.94


3.41 17.76 15.34 3.06 4.85 2.17 25.30 4.65 4.73 10.94 7.29 1.77 3.37 1.65 1.02


MSMEG_3958 glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_3959 transcriptional regulator MSMEG_3960 transcriptional regulator MSMEG_3961 transcriptional regulator MSMEG_3962 lactate 2-monooxygenase MSMEG_3963 hypothetical protein MSMEG_3964 pyruvate dehydrogenase MSMEG_3965 hypothetical protein MSMEG_3966 hypothetical protein MSMEG_3967 TonB-dependent receptor MSMEG_3968 hypothetical protein MSMEG_3969 hypothetical protein MSMEG_3970 glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_3971 hypothetical protein MSMEG_3972 transcriptional regulator, LysR family protein MSMEG_3973 N-methylhydantoinase MSMEG_3974 hydantoin utilization protein A; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF05378 MSMEG_3975 regulatory protein, putative MSMEG_3976 DNA-binding protein MSMEG_3977 conserved hypothetical protein MSMEG_3978 beta-lactamase MSMEG_3979 alpha/beta hydrolase; this gene contains a frame shift which is not the result of sequencing error MSMEG_3980 transcriptional regulator, GntR family protein MSMEG_3981 L-carnitine dehydratase/bile acid-inducible protein F MSMEG_3982 acyl-CoA dehydrogenase MSMEG_3983 L-carnitine dehydratase/bile acid-inducible protein F; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02515

3.94 1.22 0.99 1.06 1.44 1.06 0.97 1.16 1.37 1.25 1.70 2.40 1.11 1.04 1.48 3.17


0.68 1.69 1.28 0.73 0.69 1.13 0.93 1.13 0.89 1.02 1.29 0.84 0.94 2.39 1.46 0.98


0.83 1.06 1.06 0.94 0.16 1.07 0.60 0.26 0.23 1.08 1.34 1.18 0.93 0.97 1.07 0.54


3.65 1.07 0.91 0.98 0.57

3.94E-02 3.97E-01 3.63E-01 8.87E-01 1.45E-03

1.23 1.68 1.04 8.76 7.43

3.48E-01 9.73E-02 5.93E-01 9.23E-02 7.96E-02

0.25 0.94 0.93 1.50 0.90

4.37E-04 3.44E-01 1.64E-01 4.79E-01 5.43E-01

0.65 1.22

2.15E-01 1.84E-01

1.12 0.93

3.77E-01 2.36E-01

1.27 0.70

5.19E-02 4.67E-02

1.80 2.02

1.14E-02 2.10E-02

0.96 1.03

9.99E-04 7.84E-01

1.03 0.87

8.24E-01 3.33E-01

2.13

2.12E-03

0.93

3.32E-01

0.48

8.47E-04

MSMEG_3983 L-carnitine dehydratase/bile acid-inducible protein F; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02515 MSMEG_3984 Transposase IS116/IS110/IS902 family protein MSMEG_3984 Transposase IS116/IS110/IS902 family protein MSMEG_3985 integral membrane transport protein MSMEG_3986 acetyl-coenzyme A synthetase MSMEG_3987 FAD dependent oxidoreductase MSMEG_3988 transcriptional regulator, AsnC family protein MSMEG_3989 peptidase M20D, amidohydrolase MSMEG_3990 putative transporter MSMEG_3991 cyclase MSMEG_3992 integral membrane transport protein MSMEG_3993 Asp/Glu racemase MSMEG_3994 short chain dehydrogenase MSMEG_3995 N-carbamoyl-L-amino acid amidohydrolase hydA MSMEG_3996 dihydropyrimidinase MSMEG_3997 regulatory protein MSMEG_3998 MmsAB operon regulatory protein MSMEG_3999 ABC transporter periplasmic-binding protein YphF MSMEG_4000 hypothetical ABC transporter ATP-binding protein YphE MSMEG_4001 ribose transport system permease protein RbsC MSMEG_4002 oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_4003 conserved hypothetical protein MSMEG_4004 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4005 calcium-binding protein MSMEG_4006 transcriptional regulator, CdaR, putative MSMEG_4007 oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_4008 oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_4009 vanillate O-demethylase oxidoreductase MSMEG_4010 glyoxalase family protein MSMEG_4011 putative pyrimidine permease RutG

1.59 0.79 0.98 1.48 1.77 1.25 1.01 0.89 1.07 1.35 1.07 0.59 0.54 0.67 0.65 0.42 0.71


1.00 1.43 1.17 1.53 1.88 1.40 1.29 1.40 1.55 1.06 1.03 1.08 1.27 1.04 1.10 0.92 1.30


0.80 1.41 0.91 0.97 1.07 1.09 1.24 1.03 1.80 0.83 1.33 1.08 0.94 1.08 1.41 0.89 0.95


1.41

7.02E-02

1.46

1.08E-01

7.36

3.75E-01

0.88 0.94

9.90E-02 5.14E-01

1.18 1.17

1.94E-01 3.05E-01

1.33 1.27

2.48E-01 2.06E-01

1.16 1.10 0.83 0.83 0.80

1.62E-01 1.64E-01 1.52E-01 1.53E-01 2.74E-01

1.08 1.32 1.38 1.28 1.36

5.06E-01 2.76E-03 2.40E-01 7.11E-02 2.91E-01

0.64 1.07 1.07 1.04 1.14

9.81E-02 5.34E-01 5.02E-01 4.24E-01 4.24E-01

0.94

4.97E-01

1.01

9.36E-01

1.00

9.89E-01

0.94 0.73 0.74 0.75

8.63E-01 7.23E-02 8.94E-02 1.13E-01

1.36 1.07 1.19 1.27

6.53E-02 4.21E-01 1.80E-01 2.17E-01

0.90 0.90 1.05 0.97

1.72E-01 2.32E-01 4.42E-01 4.78E-01


dihydropyrimidinase oxidoreductase N-carbamoyl-L-amino acid amidohydrolase hypothetical protein conserved hypothetical protein BmyD protein nucleotidyltransferase domain protein AMP-dependent synthetase and ligase enoyl-CoA hydratase/isomerase family protein hypothetical protein TetR-family protein transcriptional regulator oxidoreductase transcriptional regulator, TetR family protein transcriptional regulator, LysR family protein hypothetical protein zinc-containing alcohol dehydrogenase superfamily protein hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein zinc-binding alcohol dehydrogenase TetR-family protein transcriptional regulator NAD dependent epimerase/dehydratase family protein citrate synthase crotonobetaine/carnitine-CoA ligase hypothetical protein vanillin dehydrogenase aryl-alcohol dehydrogenase nitroreductase hydroxyquinol 1,2-dioxygenase transcriptional regulator, GntR family protein amidohydrolase 2 GAF domain protein muconolactone delta-isomerase L-carnitine dehydratase/bile acid-inducible protein F

hydA

1.08 2.46 1.56 1.08 1.58 0.81 1.09 1.10 1.15 0.96 0.72 3.28 1.27 0.95 2.01


1.11 1.28 1.01 1.13 0.96 1.09 1.10 0.99 1.12 1.31 1.05 0.77 0.98 1.27 0.83


0.93 1.07 0.71 1.05 0.81 1.13 1.42 0.90 1.12 1.94 3.33 0.87 1.24 1.04 1.30


3.56 0.90 0.95 2.09 1.44 1.81 0.61

1.67E-02 4.72E-01 5.66E-01 1.08E-02 5.40E-02 3.07E-03 1.13E-02

0.88 1.24 1.15 2.35 1.06 2.35 1.56

5.95E-01 3.18E-01 3.24E-01 9.86E-02 8.30E-01 1.74E-01 4.34E-02

1.32 1.01 0.95 1.01 0.91 1.09 1.04

2.22E-01 8.18E-01 3.44E-01 7.60E-01 2.97E-01 2.61E-01 4.29E-01

0.57 0.89 1.08 1.19 1.25 1.08 1.78 0.83 0.58 0.64 1.08 0.90

5.27E-04 3.91E-01 6.69E-01 4.06E-01 1.44E-01 6.20E-01 2.98E-01 4.83E-02 1.59E-04 8.03E-02 7.25E-01 5.67E-01

1.29 1.29 0.91 1.38 0.91 1.09 0.97 1.60 0.94 0.83 1.27 1.13

1.89E-01 1.51E-01 6.02E-01 4.63E-02 6.18E-03 6.94E-02 6.79E-01 1.30E-01 5.27E-01 1.20E-01 4.49E-01 2.57E-01

1.20 1.03 1.08 0.80 1.63 1.34 1.30 1.08 2.10 1.46 2.94 0.96

3.61E-01 4.75E-01 3.80E-01 1.57E-01 1.67E-01 2.35E-01 4.31E-01 6.86E-01 1.40E-01 2.62E-01 1.91E-01 3.15E-01

1.19

2.25E-01

1.22

1.28E-01

1.13

3.48E-01

MSMEG_4047 MSMEG_4048 MSMEG_4049 MSMEG_4050 MSMEG_4051 MSMEG_4052 MSMEG_4053 MSMEG_4054 MSMEG_4055 MSMEG_4056 MSMEG_4057 MSMEG_4058 MSMEG_4059 MSMEG_4060

MSMEG_4060


MSMEG_4072

dihydropteroate synthase cyclase sugar transporter, permease protein hypothetical protein hypothetical protein hypothetical protein transcriptional regulatory protein hypothetical protein short-chain dehydrogenase/reductase SDR conserved secreted protein transcriptional regulator, GntR family protein major facilitator superfamily protein haloacid dehalogenase, type II aspartate aminotransferase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00155 aspartate aminotransferase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00155 translation initiation inhibitor glutamyl-tRNA(Gln) amidotransferase subunit A amidohydrolase family protein zinc-binding alcohol dehydrogenase feruloyl-CoA synthetase conserved hypothetical protein zinc-containing alcohol dehydrogenase superfamily protein hypothetical protein hypothetical protein transcriptional regulator, TetR family protein, putative conserved hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error ISMsm5, transposase

1.34 1.55 1.41 0.71 1.41 0.99 0.57 0.86 0.85 0.87 1.53 1.07 0.77

8.60E-02 1.67E-01 6.37E-03 2.82E-03 1.34E-01 9.40E-01 1.54E-03 3.11E-01 8.21E-03 3.72E-01 1.02E-01 6.66E-01 1.99E-01

1.34 1.06 1.76 1.23 1.32 2.13 1.97 1.26 1.01 1.06 0.82 1.13 0.96

2.39E-01 6.66E-01 8.30E-02 2.90E-01 2.16E-01 1.99E-01 1.25E-01 2.04E-01 8.81E-01 7.08E-01 3.00E-02 2.38E-01 8.10E-01

1.06 1.44 1.42 1.05 1.00 1.34 2.42 1.89 1.16 1.17 1.39 1.12 1.23

2.68E-01 4.43E-01 4.64E-01 1.38E-01 8.91E-01 2.77E-01 1.36E-01 8.31E-02 3.69E-01 3.89E-01 4.36E-01 9.21E-02 4.79E-01

0.66

2.37E-02

0.85

2.56E-02

0.95

4.31E-01

0.90 1.11 0.83 2.41 1.13 0.93 0.89

4.96E-01 4.81E-01 8.78E-02 7.89E-02 9.49E-02 6.40E-01 5.27E-01

1.35 0.99 1.00 1.35 1.42 1.11 1.02

1.24E-01 9.68E-01 9.86E-01 3.97E-01 3.81E-01 2.24E-01 7.12E-01

1.14 1.00 1.06 0.87 1.05 1.17 1.02

4.54E-01 8.91E-01 5.35E-01 5.35E-01 4.36E-01 3.57E-01 6.65E-01

1.12 1.09 1.28

1.12E-01 6.95E-01 2.66E-01

0.89 0.92 1.15

1.11E-01 3.61E-01 3.02E-01

0.71 0.96 1.10

3.45E-02 6.24E-01 5.99E-01

1.03

6.70E-01

1.05

6.56E-01

3.80

3.38E-01

0.73 0.81

6.78E-02 4.16E-02

1.30 0.98

1.35E-01 8.29E-01

1.06 0.81

2.42E-01 5.16E-03

MSMEG_4073 DNA-binding protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_4074 peroxisomal trans-2-enoyl-CoA reductase MSMEG_4075 CoA-binding protein MSMEG_4076 butyryl-CoA dehydrogenase MSMEG_4077 enoyl-CoA hydratase MSMEG_4078 hypothetical metabolite transport protein YaaU MSMEG_4079 putative hydrolase MSMEG_4080 fmnh2-utilizing oxygenase; this gene contains a frame shift which is not the result of sequencing error MSMEG_4082 monoxygenase MSMEG_4083 putative monooxygenase MSMEG_4084 putative acyl-CoA dehydrogenase MSMEG_4085 nitrilotriacetate monooxygenase component A ssuD MSMEG_4086 nitrilotriacetate monooxygenase component A MSMEG_4087 major facilitator superfamily protein MSMEG_4090 putative IclR family protein transcriptional regulator ssuD MSMEG_4091 nitrilotriacetate monooxygenase component A MSMEG_4092 alkanal monooxygenase MSMEG_4093 oxidoreductase, aldo/keto reductase family MSMEG_4094 acyl-CoA dehydrogenase MSMEG_4095 putative monooxygenase ssuD MSMEG_4096 nitrilotriacetate monooxygenase component A MSMEG_4097 acyl-CoA dehydrogenase domain protein MSMEG_4098 ABC transporter ATP-binding protein MSMEG_4099 ABC transporter permease protein MSMEG_4100 ABC transporter permease protein MSMEG_4101 ABC-type transporter, substrate binding protein MSMEG_4102 conserved hypothetical protein MSMEG_4103 alkanesulfonate monooxygenase MSMEG_4104 transporter, major facilitator family protein MSMEG_4105 transposase subunit MSMEG_4105 transposase subunit MSMEG_4106 transposase MSMEG_4106 transposase MSMEG_4107 phosphoglycerate mutase, putative

0.98 1.54 1.02 1.83 1.41 1.41 0.66

7.90E-01 5.02E-02 8.98E-01 1.85E-02 3.39E-01 1.94E-01 4.72E-03

1.18 1.10 1.19 1.26 1.76 1.10 1.06

3.98E-01 5.82E-01 1.14E-01 2.02E-01 2.14E-01 6.57E-01 6.12E-01

1.38 1.40 0.91 0.77 1.01 0.96 1.94

8.83E-02 2.92E-01 6.46E-01 7.59E-02 4.99E-01 8.40E-01 2.10E-02

0.84 0.35 0.37 0.54 0.22 1.29 0.24

7.14E-02 4.24E-05 2.64E-04 1.96E-03 4.44E-06 7.84E-01 5.50E-06

1.05 5.03 3.76 4.85 7.69 6.15 8.13

6.30E-01 2.34E-01 2.27E-01 2.29E-01 2.72E-01 2.39E-01 1.98E-01

1.18 1.47 1.37 1.02 0.76 0.94 1.10

2.51E-01 3.11E-01 2.57E-01 3.82E-01 2.52E-01 6.65E-01 4.66E-01

0.98 1.12 1.36 1.48 1.05 2.31 1.00 0.97 1.15 1.06 0.68 0.93 1.08 1.24 1.23 0.51 0.89 0.69 0.98 0.66


0.93 0.96 0.80 0.75 0.94 1.14 1.13 1.22 1.12 1.06 1.28 1.13 1.02 1.07 1.38 1.11 0.95 1.35 1.02 1.13


0.83 1.03 1.06 0.99 6.00 1.48 1.02 1.03 1.07 1.03 1.16 1.00 1.00 0.97 0.97 1.49 0.92 0.74 1.03 0.99



pntB NAD(P) transhydrogenase, beta subunit pntA NAD(P) transhydrogenase, alpha subunit 3-hydroxyacyl-CoA dehydrogenase alpha-methylacyl-CoA racemase cyclohexanecarboxylate-CoA ligase acyl-CoA dehydrogenase menB naphthoate synthase 3-hydroxybutyryl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase 2-deoxy-D-gluconate 3-dehydrogenase acyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydratase CAIB/BAIF family protein GntR-family protein transcriptional regulator major facilitator family protein transporter 3-hydroxyisobutyrate dehydrogenase conserved hypothetical protein oxidoreductase, short chain dehydrogenase/reductase family protein hydrolase, isochorismatase family protein TnpC protein conserved hypothetical protein hypothetical protein polysaccharide deacetylase family protein hypothetical protein transposase TnpC protein; this gene contains a frame shift which is not the result of sequencing error TnpC protein; this gene contains a frame shift which is not the result of sequencing error possible lysine decarboxylase superfamily protein dTDP-glucose 4,6-dehydratase hypothetical protein aliphatic nitrilase major facilitator superfamily MFS_1; this gene contains a frame shift which is not the result of sequencing error GntR-family protein transcriptional regulator

0.89 0.90 1.01 1.08 1.62 1.34 1.38 1.38 1.73 1.76 1.08 1.36 2.17 2.07 3.81 2.56 1.86


0.95 1.03 0.88 1.03 0.90 0.81 0.96 0.77 0.71 0.87 1.07 0.90 0.87 0.68 0.73 0.70 0.61


1.03 1.13 0.92 0.67 0.74 0.91 0.65 0.60 0.53 0.72 0.80 0.88 0.92 2.24 0.41 1.02 1.12


1.94 4.46 0.36 0.63 0.50 0.84 0.74 0.54

6.84E-03 3.12E-04 2.06E-05 1.23E-02 3.52E-04 1.82E-01 3.83E-01 2.35E-04

0.55 0.39 1.08 0.78 0.94 1.08 1.08 0.98

7.25E-03 1.89E-03 4.28E-01 1.04E-01 5.01E-01 6.32E-01 4.09E-01 7.21E-01

1.05 0.59 1.72 0.73 0.89 0.99 1.22 1.03

7.74E-01 3.98E-02 3.42E-01 2.10E-01 3.79E-01 3.10E-01 4.79E-01 7.24E-01

0.61

4.24E-03

0.75

1.82E-02

0.88

1.09E-01

1.18 1.21 1.03 1.19 1.47

4.15E-01 2.04E-01 7.57E-01 3.01E-01 5.07E-02

1.08 1.03 1.01 0.99 1.46

5.04E-01 4.12E-01 8.62E-01 9.65E-01 2.43E-03

1.06 1.18 2.06 1.05 1.04

2.29E-01 1.99E-01 4.30E-01 7.29E-01 3.88E-01

1.47 0.77

4.66E-01 3.91E-02

1.47 1.32

1.50E-01 3.27E-01

1.34 1.19

3.22E-01 2.16E-01

MSMEG_4141 conserved hypothetical protein MSMEG_4142 transcriptional repressor, TetR family protein, putative MSMEG_4143 conserved hypothetical protein MSMEG_4144 transcriptional regulator, LysR family protein MSMEG_4145 cupin 2 protein MSMEG_4146 quinone oxidoreductase MSMEG_4147 major facilitator superfamily protein MFS_1, putative MSMEG_4148 lipase MSMEG_4149 acetaldehyde dehydrogenase MSMEG_4150 4-hydroxy-2-oxovalerate aldolase MSMEG_4151 conserved domain protein MSMEG_4152 phenoxybenzoate dioxygenase beta subunit MSMEG_4153 cytochrome P450 MSMEG_4154 transposase, Mutator family protein MSMEG_4155 transposase A MSMEG_4156 putative transposase MSMEG_4157 putative transposase MSMEG_4158 putative transposase MSMEG_4160 hypothetical protein MSMEG_4161 hypothetical protein MSMEG_4162 conserved hypothetical protein MSMEG_4163 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4164 3-hydroxybutyryl-CoA dehydratase MSMEG_4165 [NAD+] benzaldehyde dehydrogenase MSMEG_4166 acyl-CoA dehydrogenase MSMEG_4167 alcohol dehydrogenase B MSMEG_4168 propionate CoA-transferase MSMEG_4169 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4170 ribose transport ATP-binding protein RbsA MSMEG_4171 ribose transport system permease protein RbsC MSMEG_4172 D-ribose-binding periplasmic protein RbsB MSMEG_4173 MaoC family protein MSMEG_4174 transcriptional regulator, IclR family protein MSMEG_4175 transcriptional regulator, ArsR family protein MSMEG_4176 conserved hypothetical protein

2.71

3.58E-02

1.12

6.86E-01

0.72

1.20E-01

0.55 0.93 0.93 0.76 1.13

1.23E-04 5.54E-01 4.49E-01 3.62E-02 4.09E-01

0.97 1.55 1.61 0.66 1.21

5.30E-01 1.68E-01 5.46E-02 7.59E-03 2.71E-01

1.19 0.72 0.50 1.11 1.05

3.47E-01 3.47E-01 1.05E-05 5.84E-01 1.40E-01

0.89 4.49 1.94 2.58 1.43 1.07 1.16 1.36 0.83 1.18 0.83 0.91 1.23 1.45 0.89 1.17 0.96 1.05 1.36 1.13 1.09 1.32 1.63 1.14 2.07 1.26 2.09 0.95 1.26


1.29 0.62 1.00 0.90 1.00 1.23 1.12 1.11 1.57 1.25 1.47 1.19 1.04 0.89 0.89 1.13 0.97 1.02 0.96 1.09 1.06 1.20 2.33 1.03 1.03 1.22 0.81 0.95 1.18


1.33 1.16 1.01 1.07 1.09 1.35 1.16 1.03 1.30 0.98 1.00 0.98 0.95 1.07 1.02 1.35 0.80 1.44 0.65 0.80 0.77 1.08 0.83 0.79 0.63 0.68 0.79 0.92 0.78


MSMEG_4177 mercuric reductase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992 MSMEG_4178 flavodoxin/nitric oxide synthase MSMEG_4179 probable conserved integral membrane protein MSMEG_4180 ATP phosphoribosyltransferase MSMEG_4181 phosphoribosyl-ATP pyrophosphohydrolase MSMEG_4182 arabinose-proton symporter MSMEG_4183 phosphoglycolate phosphatase, chromosomal MSMEG_4184 dtdp-glucose-46-dehydratase MSMEG_4185 methionine synthase MSMEG_4186 conserved hypothetical protein MSMEG_4187 conserved hypothetical protein MSMEG_4188 short chain dehydrogenase MSMEG_4189 cysteinyl-tRNA synthetase MSMEG_4190 inositol monophosphatase family protein MSMEG_4191 conserved hypothetical protein MSMEG_4192 conserved hypothetical protein MSMEG_4193 phosphoglycerate mutase family protein MSMEG_4194 undecaprenol kinase, putative MSMEG_4195 conserved hypothetical protein MSMEG_4196 LppL protein MSMEG_4197 conserved hypothetical protein MSMEG_4198 dihydroorotate oxidase MSMEG_4199 conserved hypothetical protein MSMEG_4200 peptidase M20 MSMEG_4202 conserved hypothetical protein MSMEG_4203 peptidase S8 and S53, subtilisin, kexin, sedolisin MSMEG_4204 catalase MSMEG_4205 putative transcriptional regulator MSMEG_4206 Molybdopterin oxidoreductase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00384

hisG

metH

cysS

pyrD

1.28 1.58 1.12 0.85 0.57 1.17 0.58 1.69 0.65 1.43 1.74 2.15 1.10 0.96 0.81 1.32 0.66 0.65 2.21 1.04 1.46 0.56 1.00 0.87 1.35


1.21 0.80 1.07 1.11 1.07 1.29 0.82 0.88 2.07 0.97 0.76 0.81 1.07 1.04 0.88 0.65 1.03 1.09 1.31 0.99 0.89 1.07 0.74 0.81 1.21


0.66 0.51 0.65 1.60 2.24 0.94 3.65 0.81 3.11 0.86 0.76 0.69 1.24 2.40 1.84 1.18 1.39 2.02 0.73 1.62 1.48 1.22 0.65 1.28 0.59


1.40 8.69 9.37

2.29E-01 2.53E-02 2.19E-02

0.98 0.35 0.49

7.92E-01 1.88E-02 3.42E-02

0.64 0.67 0.70

1.86E-01 1.49E-01 1.65E-01

4.16

1.14E-02

1.12

5.20E-01

0.54

3.60E-02

MSMEG_4206 Molybdopterin oxidoreductase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00384 MSMEG_4207 universal stress protein family protein MSMEG_4208 integral membrane protein MSMEG_4209 integral membrane protein MSMEG_4210 secreted protein MSMEG_4211 two component system histidine kinase MSMEG_4212 transcriptional regulatory protein CitT MSMEG_4213 cytochrome P450 hydroxylase MSMEG_4214 glutamine amidotransferase MSMEG_4215 phosphoribosyltransferase MSMEG_4216 conserved hypothetical protein MSMEG_4217 DivIVA protein MSMEG_4218 possible conserved transmembrane protein MSMEG_4219 conserved hypothetical protein MSMEG_4220 conserved hypothetical protein MSMEG_4221 conserved hypothetical protein MSMEG_4222 cell division protein FtsZ MSMEG_4223 hypothetical protein MSMEG_4224 hypothetical protein MSMEG_4225 putative Cell division protein FtsQ MSMEG_4226 UDP-N-acetylmuramate--alanine ligase MSMEG_4227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase MSMEG_4228 cell division protein FtsW MSMEG_4229 UDP-N-acetylmuramoylalanine--D-glutamate ligase MSMEG_4230 phospho-N-acetylmuramoyl-pentapeptidetransferase MSMEG_4231 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-Dalanine ligase MSMEG_4232 UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6diaminopimelate ligase MSMEG_4233 Penicillin binding protein transpeptidase domain protein MSMEG_4234 conserved hypothetical protein

murC

2.26 21.74 15.01 20.51 23.34 6.89 3.56 3.24 0.61 2.83 0.39 0.74 0.48 0.74 0.71 0.96 1.09 0.70 0.86 0.61 0.48


0.89 0.95 1.18 0.75 1.19 0.96 0.65 0.49 0.96 0.91 1.05 1.15 1.08 1.10 0.89 0.81 0.76 0.81 0.92 1.07 0.93


0.98 0.04 0.06 0.06 0.02 0.08 0.71 1.14 3.30 2.03 0.50 0.35 1.40 0.86 1.90 1.44 0.99 1.20 1.05 1.65 4.37


murG ftsW

0.54 0.85

5.10E-03 4.25E-01

0.90 1.10

4.30E-01 7.52E-01

5.45 2.73

6.37E-02 1.04E-01

murD

0.71

1.46E-01

0.87

5.33E-01

2.72

1.28E-01

mraY

0.43

8.12E-04

0.83

1.05E-01

2.99

3.28E-02

0.47

6.68E-04

0.81

1.87E-02

2.27

3.03E-03

0.53

5.56E-04

0.77

1.56E-02

4.90

9.83E-02

0.53 0.75

2.03E-02 2.27E-01

0.76 1.03

1.59E-01 9.31E-01

2.31 1.67

1.23E-01 2.83E-01

ftsZ


S-adenosyl-methyltransferase MraW MraZ protein probable conserved transmembrane protein conserved hypothetical protein LppM protein polyprenyl synthetase possible conserved integral membrane protein transcriptional regulatory protein serine/threonine-protein kinase PK-1 3-deoxy-7-phosphoheptulonate synthase conserved hypothetical protein probable conserved integral membrane protein probable conserved integral membrane protein 1-acylglycerol-3-phosphate O-acyltransferase conserved hypothetical protein putative membrane transport ATPase cyclase/dehydrase conserved hypothetical protein glycosyl transferase, group 1 family protein AMP-binding enzyme conserved hypothetical protein NLP/P60 family protein conserved hypothetical protein anthranilate phosphoribosyltransferase DNA polymerase III, epsilon subunit cytochrome c oxidase subunit 3 ubiquinol-cytochrome c reductase cytochrome c subunit ubiquinol-cytochrome c reductase iron-sulfur subunit ubiquinol-cytochrome c reductase cytochrome b subunit conserved hypothetical protein MmpS3 protein hypothetical protein probable cytochrome c oxidase polypeptide 4 cytochrome c oxidase subunit 2 asparagine synthase (glutamine-hydrolyzing)

mraW mraZ

trpD

asnB

0.76 0.82 2.52 0.79 0.90 0.67 0.64 1.55 1.11 0.76 0.58 1.34 1.11 1.18 0.76 0.76 0.82 1.06 0.94 0.71 0.55 0.82 1.31 0.47 0.94 0.40


0.91 0.93 1.02 0.86 1.05 0.92 0.85 0.55 0.88 1.03 0.88 0.91 1.04 0.91 0.87 0.68 0.87 0.76 0.78 0.87 1.23 0.87 0.81 0.98 0.97 1.18


1.68 2.15 1.08 1.06 1.23 1.22 1.73 1.53 2.52 0.93 1.11 1.71 1.72 0.90 2.35 4.09 2.23 0.87 2.62 0.84 1.42 0.93 1.63 1.72 1.29 5.74


0.42

5.04E-06

0.84

1.13E-03

2.79

8.29E-03

0.35

1.05E-05

0.94

3.14E-01

5.98

5.86E-04

0.38 0.53 0.99 0.81 0.34 0.32 0.30

1.45E-05 4.11E-04 8.53E-01 5.51E-02 9.95E-06 2.96E-06 2.54E-04

0.94 0.91 0.93 0.71 0.92 0.93 0.92

4.75E-01 1.49E-01 5.30E-01 8.05E-02 2.21E-01 2.92E-01 6.47E-01

6.13 1.55 1.41 4.52 2.55 2.66 1.44

2.63E-02 1.59E-02 7.78E-02 3.04E-01 1.81E-02 1.44E-02 2.07E-01


adenosine kinase conserved hypothetical protein HesB/YadR/YfhF family protein integral membrane protein Cobinamide kinase nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase branched-chain amino acid aminotransferase cobalamin 5'-phosphate synthase glycine cleavage system T protein adenylate and Guanylate cyclase catalytic domain protein short chain dehydrogenase cytosol aminopeptidase conserved hypothetical protein 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase conserved hypothetical protein lipoyltransferase lipoic acid synthetase integral membrane protein integral membrane protein amidohydrolase glutamine synthetase, type I D-tyrosyl-tRNA(Tyr) deacylase integral membrane protein glutamate-ammonia-ligase adenylyltransferase glutamine synthetase, type I hydrolase, alpha/beta fold family protein protease acyltransferase, ws/dgat/mgat subfamily protein 3-methyl-2-oxobutanoate hydroxymethyltransferase enoyl-CoA hydratase/isomerase transcription regulator AmtR acyl-CoA synthase adenylate cyclase, putative methyltransferase

cobU

0.63 1.21 3.19 0.76 0.31

3.54E-04 4.03E-03 3.56E-04 2.32E-03 2.13E-05

1.18 0.67 0.67 0.86 1.32

2.02E-02 3.63E-03 1.94E-03 8.14E-04 7.13E-02

1.28 0.64 0.51 1.20 1.78

2.42E-01 8.39E-02 1.10E-03 2.07E-01 2.81E-02

ilvE cobS gcvT

0.48 1.83 0.68 0.88

2.04E-03 1.85E-03 4.02E-02 1.65E-01

0.94 1.33 1.09 0.88

5.85E-01 8.08E-02 5.53E-01 1.17E-01

1.77 1.12 1.19 0.42

5.33E-03 1.47E-01 3.90E-01 2.05E-05

2.14 1.93 0.49 1.37

2.11E-03 7.60E-03 6.55E-05 2.05E-03

1.04 0.65 0.80 0.66

5.62E-01 3.49E-03 2.54E-04 3.27E-03

1.76 1.72 0.74 1.06

4.29E-01 1.73E-01 4.81E-02 1.07E-01

0.76 0.51 1.00 1.22 1.14 1.23 0.68 0.59 0.43 0.55 0.47 0.71 0.50 0.50 1.39


0.95 0.92 0.90 0.90 0.94 0.73 1.01 1.15 0.88 0.99 0.95 0.81 1.05 0.89 0.82


1.37 2.98 1.95 1.52 1.83 1.30 1.61 0.42 1.26 1.03 1.83 0.54 0.88 1.60 0.47


0.08 0.70 0.59 1.04 0.93 1.51

9.05E-07 1.88E-02 8.34E-04 4.40E-01 6.11E-01 8.43E-02

2.69 1.08 1.06 0.65 0.88 0.96

1.94E-01 5.72E-01 6.86E-01 1.98E-03 4.77E-01 7.03E-01

8.79 1.18 2.87 3.32 1.40 0.92

6.40E-02 1.04E-01 5.53E-02 7.43E-04 1.04E-01 3.27E-01

sucB lipB lipA

glnA dtd glnA

panB


regulatory protein phosphoglycerate mutase conserved hypothetical protein conserved hypothetical protein 5'-nucleotidase Low molecular weight protein-tyrosinephosphatase cobD cobalamin biosynthesis protein CobD conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error glyoxalase/bleomycin resistance protein/dioxygenase hypothetical protein RNA polymerase sigma factor, sigma-70 family protein methylated-DNA--protein-cysteine methyltransferase conserved hypothetical protein hypothetical protein alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen conserved hypothetical protein conserved hypothetical protein pyruvate dehydrogenase E1 component conserved hypothetical protein malonyl CoA-acyl carrier protein transacylase acpP acyl carrier protein 3-oxoacyl-[acyl-carrier-protein] synthase 1 3-oxoacyl-[acyl-carrier-protein] synthase 2 propionyl-CoA carboxylase beta chain short chain dehydrogenase putative transcriptional regulator glycerol-3-phosphate dehydrogenase 1 transcriptional regulator, TetR family protein flavoprotein conserved hypothetical protein

0.71 0.71 0.56 0.63 0.99

1.43E-02 3.39E-03 1.07E-03 3.22E-04 9.55E-01

1.45 0.97 0.84 0.82 0.83

9.51E-02 5.13E-01 7.36E-03 1.30E-01 1.40E-01

0.69 1.06 1.50 1.14 2.29

9.00E-02 7.26E-01 1.26E-01 5.14E-01 4.82E-03

1.08 0.53 0.99

5.08E-01 2.65E-03 9.07E-01

0.66 1.10 0.82

3.73E-02 3.82E-01 1.15E-01

2.26 1.34 2.72

1.43E-02 3.63E-01 1.02E-02

0.50

3.53E-04

0.81

3.92E-02

1.67

6.62E-02

0.64 0.64

1.59E-04 4.63E-04

0.80 0.83

7.28E-02 1.56E-02

1.41 1.05

4.74E-02 8.02E-01

1.25

1.10E-01

0.87

2.15E-01

1.02

8.27E-01

1.58 1.53 0.94

2.73E-02 9.33E-02 5.75E-01

0.87 0.85 0.85

4.42E-01 2.38E-01 3.47E-02

1.24 1.24 1.02

2.76E-01 1.30E-01 8.10E-01

0.42 1.06 0.70 0.69 1.57 0.80 0.43 0.64 0.48 0.75 3.93 1.15 0.94 1.48 1.17 1.10


0.92 0.99 0.92 1.01 0.70 1.03 0.80 0.94 1.28 0.98 0.89 1.00 1.11 1.17 1.52 1.20


1.29 0.80 1.40 0.88 1.02 2.56 3.80 2.96 3.61 2.44 0.46 1.36 1.43 0.98 1.20 0.98



conserved hypothetical protein beta-lactamase possible transcriptional regulatory protein tetratricopeptide repeat family protein NAD/mycothiol-dependent formaldehyde dehydrogenase hypothetical protein metallo-beta-lactamase family protein hypothetical protein putative monooxygenase conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein acetolactate synthase large subunit conserved hypothetical proline rich protein dapB dihydrodipicolinate reductase hypothetical oxidoreductase YjgI putative secreted protein conserved hypothetical protein dipeptide-binding protein of ABC transport system peptide ABC transporter, permease protein inner membrane ABC transporter permease protein YddQ ABC transporter, ATP-binding protein D-beta-hydroxybutyrate dehydrogenase hypothetical protein conserved hypothetical protein conserved hypothetical protein universal stress protein family protein conserved hypothetical protein hypothetical protein conserved hypothetical protein serine/threonine-protein kinase PknD formamidase putative regulatory protein, FmdB family protein hypothetical protein regulatory protein

1.08 0.55 1.59 1.92

7.37E-01 1.41E-04 1.15E-04 1.42E-01

0.98 0.92 0.98 0.97

9.58E-01 2.71E-01 6.67E-01 6.80E-01

1.66 1.11 1.18 1.00

3.09E-01 5.64E-01 1.98E-01 9.68E-01

0.93 1.09 0.65 1.07 0.43 0.83 1.09 0.96 1.88 1.10 1.58 3.62 1.05 0.96

2.21E-01 3.16E-01 3.46E-03 3.87E-01 8.96E-03 2.38E-01 2.60E-01 6.70E-01 2.21E-02 3.19E-01 3.64E-02 1.15E-02 6.67E-01 5.74E-01

0.83 1.13 0.92 1.00 1.82 1.19 0.88 0.93 0.68 0.90 0.89 0.55 1.57 0.90

3.29E-02 1.10E-01 4.55E-01 9.95E-01 1.77E-01 3.67E-01 4.28E-01 2.37E-01 5.01E-03 1.18E-01 5.15E-01 2.30E-02 1.40E-02 4.02E-02

0.57 3.44 0.71 0.84 0.90 1.15 1.24 1.03 0.93 0.89 0.76 0.90 0.42 0.45

1.58E-05 3.65E-01 1.46E-02 1.57E-01 4.69E-01 3.80E-01 8.55E-02 4.96E-01 7.27E-01 2.05E-01 1.56E-01 2.94E-01 1.09E-02 6.52E-06

1.03 0.82

7.21E-01 1.75E-01

1.25 1.19

1.45E-01 1.91E-01

0.59 1.10

2.89E-02 7.41E-01

0.97 0.72 0.57 1.05 1.29 4.84 1.37 3.22 1.19 0.77 0.93 1.61 1.92 0.94 0.89


1.23 1.53 1.03 1.08 0.67 1.03 0.83 0.73 1.00 1.42 0.91 0.88 0.88 0.94 0.95


1.07 0.94 1.50 1.01 1.00 0.89 1.09 1.20 2.07 0.96 1.20 0.25 0.21 1.11 1.81



vanillate O-demethylase oxidoreductase capreomycidine hydroxylase polysaccharide deacetylase, putative speB agmatinase 3-oxoacyl-[acyl carrier protein] reductase 3-oxoacyl-[acyl-carrier-protein] reductase amino acid permease family protein, putative two-component system response regulator isochorismatase hydrolase ABC transporter, permease/ATP-binding protein amidase dehydrogenase/reductase SDR family protein member 10 MmpL5 protein Penicillin binding protein transpeptidase domain protein ABC transporter oligopeptide binding protein ABC transporter permease protein ABC transporter permease protein ABC transporter ATP-binding protein monooxygenase, NtaA/SnaA/SoxA family hypothetical protein acyl-CoA dehydrogenase-family protein organophopsphate acid anhydrase carboxyvinyl-carboxyphosphonate phosphorylmutase LysR family protein transcriptional regulatory protein excalibur domain family protein isochorismatase hydrolase transcriptional regulator, MerR family protein conserved hypothetical protein conserved hypothetical protein alcohol dehydrogenase, zinc-containing phosphonoacetaldehyde hydrolase hypothetical protein putative ECF sigma factor RpoE1 UsfY protein

1.09 1.20 1.15 1.63 1.05 1.08 1.12 1.16 2.16 1.35 0.75

6.85E-01 2.46E-01 6.30E-01 3.18E-01 6.13E-01 2.07E-01 3.40E-01 1.61E-01 4.45E-02 3.01E-01 1.75E-02

1.02 1.04 0.98 0.94 1.10 1.09 1.09 0.93 0.73 0.95 1.25

9.29E-01 6.79E-01 8.84E-01 1.23E-01 3.95E-01 2.61E-01 4.12E-01 5.37E-01 9.88E-03 4.84E-01 3.22E-01

0.98 1.25 0.89 1.13 1.28 0.90 1.04 1.13 1.17 1.28 0.55

5.76E-01 3.16E-01 5.25E-01 4.45E-01 3.10E-01 1.06E-01 7.05E-01 5.12E-01 6.72E-01 4.19E-01 9.08E-04

0.95 0.60

6.56E-01 1.31E-03

1.18 0.89

4.17E-01 2.62E-01

1.13 1.20

8.68E-01 3.48E-01

3.49 1.05 1.20 0.98 1.35 0.92 1.01 1.18 1.91

6.50E-04 3.06E-01 1.59E-01 8.48E-01 3.50E-01 4.82E-01 9.25E-01 2.60E-01 4.57E-02

0.88 2.57 1.32 1.25 1.51 1.77 1.38 3.36 0.77

9.11E-02 8.26E-02 2.52E-01 5.50E-01 2.18E-01 1.67E-01 1.27E-01 3.08E-01 3.23E-02

1.20 1.36 1.19 0.78 1.05 0.82 1.03 1.03 1.88

1.60E-01 1.31E-01 4.34E-01 3.65E-01 3.02E-01 1.19E-01 4.86E-01 6.08E-01 9.94E-02

1.44

8.51E-02

0.85

2.88E-01

1.13

4.17E-01

0.75 1.13 1.03 3.28 1.10 0.48 0.75 0.84 0.88 1.72 1.11

4.40E-02 3.66E-01 8.28E-01 8.17E-02 6.65E-01 1.36E-03 4.10E-04 6.62E-03 5.00E-01 2.77E-02 2.48E-01

0.96 0.99 1.97 1.02 0.90 1.00 0.80 0.96 0.88 1.21 1.25

4.85E-01 8.91E-01 1.35E-01 9.05E-01 2.42E-01 9.82E-01 4.03E-03 1.96E-01 1.58E-01 2.23E-01 3.67E-01

1.70 1.04 4.95 0.85 5.04 1.96 1.82 1.58 1.97 1.93 1.03

1.41E-01 6.73E-01 3.50E-02 2.07E-01 1.74E-01 1.88E-01 2.27E-03 4.96E-02 6.04E-02 3.34E-01 5.89E-01


conserved hypothetical protein integral membrane protein hypothetical protein hypothetical protein oxidoreductase FAD-binding region oxidoreductase, molybdopterin binding hypothetical protein conserved hypothetical protein transaldolase hypothetical protein methionine-S-sulfoxide reductase methionine-R-sulfoxide reductase glucose-1-dehydrogenase cupin 2, conserved barrel conserved hypothetical protein oxidoreductase oxidoreductase endoribonuclease L-PSP putative oxidoreductase secreted protein transmembrane efflux pump conserved hypothetical protein hypothetical protein transcriptional regulator putative regulatory protein hypothetical protein dehydrogenase Cof protein dimethylmenaquinone methyltransferase transketolase cytochrome c oxidase, subunit I hypothetical protein acetyltransferase glucose-1-dehydrogenase cupin domain protein zinc-binding oxidoreductase hypothetical protein hypothetical protein

tal msrA msrB

ctaD

1.31 1.16 1.19 1.03 4.44 0.96 0.76 1.04 1.06 2.25 1.87 1.05 1.06 1.17 1.36 0.81 1.54 0.90 1.05 1.05 1.19 1.58 0.94 1.34 4.46 1.11 1.20 1.20 1.01 1.17 1.28 1.22 1.00 1.08 1.52 1.98 1.12 1.04


1.07 0.88 0.93 0.95 1.40 0.93 1.20 1.26 0.94 1.05 0.93 1.04 1.17 1.40 1.42 1.04 1.14 1.08 1.12 1.06 1.05 1.12 1.31 1.10 0.87 1.04 1.26 1.07 1.82 2.22 1.16 1.09 0.93 1.30 1.21 1.17 0.96 1.17


1.05 0.88 1.16 1.76 0.33 1.16 1.12 1.19 1.01 2.46 1.01 0.94 1.48 0.80 1.24 1.10 0.90 1.00 0.96 1.02 1.07 1.16 0.98 1.00 4.44 0.94 0.95 1.12 0.90 1.02 0.87 1.75 0.83 1.03 0.98 0.88 1.56 1.03


MSMEG_4445 hypothetical protein MSMEG_4446 dihydrolipoamide dehydrogenase; this gene contains a premature stop which is not the result of sequencing error; identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM lpdA TIGR01350 MSMEG_4447 conserved hypothetical protein MSMEG_4448 transcriptional modulator of MazE MSMEG_4449 putative transcriptional regulator MSMEG_4450 alpha/beta hydrolase MSMEG_4451 probable monooxygenase MSMEG_4453 conserved hypothetical protein ltaE MSMEG_4454 L-threonine aldolase, low-specificity MSMEG_4455 beta-lactamase MSMEG_4456 conserved hypothetical protein MSMEG_4457 regulatory protein, AsnC/Lrp MSMEG_4458 transmembrane transport protein speB MSMEG_4459 agmatinase MSMEG_4460 acetolactate synthase MSMEG_4460 acetolactate synthase MSMEG_4461 conserved hypothetical integral membrane protein MSMEG_4462 sodium:solute symporter MSMEG_4463 CalR5 protein MSMEG_4464 modulator of DNA gyrase MSMEG_4465 cutinase MSMEG_4466 ABC transporter, permease protein UspA MSMEG_4467 ABC transporter, permease protein UspE MSMEG_4468 Bacterial extracellular solute-binding protein UspC MSMEG_4469 cobalt transport protein MSMEG_4470 ABC transporter MSMEG_4471 MarR-family protein transcriptional regulator MSMEG_4472 multidrug-efflux transporter protein MSMEG_4473 Integral membrane protein MSMEG_4474 acyl-CoA oxidase MSMEG_4475 LppP protein

1.36

6.80E-02

1.38

4.09E-02

1.15

5.02E-01

3.20 1.03 0.66 0.82 0.67 0.59 0.99 1.29 1.89 3.70 1.92 1.39 1.66 1.34 1.21 0.75 1.11 0.67 0.86 3.53 1.04 2.29


0.70 0.86 0.90 0.91 1.10 0.83 1.43 0.82 1.03 1.19 1.42 0.99 0.94 1.12 0.95 1.52 1.11 1.04 1.35 1.79 1.33 1.00


1.22 1.07 1.14 1.31 0.95 1.01 0.95 0.88 1.22 0.59 1.54 0.97 0.89 1.15 0.91 1.06 0.92 1.05 0.91 1.18 0.94 1.03


1.02 1.16 0.91 0.97 0.78 1.06 1.23 0.70

8.47E-01 2.10E-01 1.83E-01 8.01E-01 1.10E-02 5.27E-01 1.57E-02 1.38E-03

1.13 0.70 0.80 0.81 0.82 1.00 0.97 0.90

3.98E-01 1.37E-03 1.46E-01 3.96E-02 1.88E-01 9.86E-01 7.02E-01 2.07E-01

1.63 9.00 3.96 1.18 1.51 1.30 0.78 2.17

2.33E-01 2.99E-01 5.48E-02 1.16E-01 2.64E-02 9.48E-02 5.94E-02 9.78E-03

MSMEG_4476 hypothetical protein MSMEG_4477 hydrolase, alpha/beta hydrolase fold family protein MSMEG_4479 conserved hypothetical protein MSMEG_4480 conserved hypothetical protein MSMEG_4481 hypothetical protein MSMEG_4482 DNA primase MSMEG_4483 deoxyguanosinetriphosphate triphosphohydrolase MSMEG_4484 putative conserved transmembrane protein MSMEG_4485 glycyl-tRNA synthetase MSMEG_4486 transcriptional regulator, ArsR family protein MSMEG_4487 ferric uptake regulation protein MSMEG_4488 hydrolase, nudix family protein MSMEG_4489 conserved hypothetical protein MSMEG_4490 undecaprenyl diphosphate synthase MSMEG_4491 DNA repair protein RecO MSMEG_4492 amidase MSMEG_4493 GTP-binding protein Era MSMEG_4494 conserved hypothetical protein MSMEG_4495 CBS domain protein MSMEG_4496 conserved hypothetical protein MSMEG_4497 PhoH family protein MSMEG_4498 hypothetical protein MSMEG_4499 hypothetical protein MSMEG_4500 hypothetical protein MSMEG_4501 sodium:dicarboxylate symporter MSMEG_4502 conserved hypothetical protein MSMEG_4503 hypothetical protein MSMEG_4504 chaperone protein DnaJ MSMEG_4505 heat-inducible transcription repressor HrcA MSMEG_4506 hypothetical protein MSMEG_4507 conserved hypothetical protein MSMEG_4508 conserved domain protein MSMEG_4509 MbtG protein MSMEG_4510 peptide synthetase mbtf MSMEG_4511 linear gramicidin synthetase subunit B MSMEG_4512 polyketide synthetase mbtd MSMEG_4513 polyketide synthase

glyS

uppS recO era

dnaJ hrcA

1.58

1.06E-02

0.84

6.64E-02

0.87

1.34E-02

3.12 1.48 1.94 0.94 0.68 0.63 0.95 0.44 1.69 1.46 0.53 0.47 0.64 0.68 1.07 0.57 0.50 0.51 0.86 1.00 1.15 1.11 0.86 0.20 1.07 1.29 0.89 1.47 0.58 2.36 0.68 0.22 0.39 0.35 1.15 0.49


0.98 0.70 0.73 1.06 1.10 1.29 1.06 1.09 0.80 0.74 1.21 1.32 1.22 1.08 0.80 1.81 1.51 2.67 1.30 1.38 0.82 4.76 1.20 1.08 1.09 1.12 0.80 0.99 0.95 0.69 1.20 1.33 1.27 0.99 1.12 1.16


2.96 1.21 0.53 1.69 2.71 1.61 0.78 1.20 0.67 0.68 1.42 1.75 1.40 1.37 2.65 3.05 2.19 3.42 2.67 1.67 1.24 2.98 1.47 0.78 9.68 1.07 1.51 1.17 1.71 0.63 1.00 2.82 2.26 3.31 1.43 1.85



Thioesterase domain protein putative non-ribosomal peptide synthetase 2,3-dihydroxybenzoate-AMP ligase TetR-type transcriptional regulator of sulfur metabolism conserved hypothetical protein NrtC protein sulfate/thiosulfate import ATP-binding protein CysA Tat (twin-arginine translocation) pathway signal sequence ISMsm2, transposase ISMsm2, transposase binding-protein-dependent transport systems inner membrane component anthranilate synthase component I putative oxygen-independent coproporphyrinogen III oxidase hypothetical protein ferredoxin sulfite reductase phosphoadenosine phosphosulfate reductase secreted protein cysA sulfate ABC transporter, ATP-binding protein sulfate ABC transporter, permease protein CysW cysW sulfate ABC transporter, permease protein CysT cysT sulfate-binding protein putative conserved membrane protein glycoside hydrolase conserved hypothetical protein major membrane protein I cysteine desulphurase, SufS alkanesulfonate monooxygenase acetyltransferase, gnat family protein ABC transporter, ATP-binding protein oligopeptide transport integral membrane protein ABC transporter system integral membrane protein

0.55 0.46 0.47

1.23E-03 1.51E-02 9.06E-04

1.19 1.43 0.94

3.79E-02 3.66E-01 6.39E-01

1.71 1.78 1.39

3.60E-01 2.64E-01 3.51E-01

1.28 1.34 1.51

4.52E-01 1.47E-01 1.87E-01

0.97 2.02 1.29

8.27E-01 2.88E-01 2.36E-01

2.56 1.15 1.33

3.82E-01 6.29E-01 4.81E-01

1.09

4.72E-01

1.56

2.09E-01

1.27

5.03E-01

1.30 1.10 0.93

1.74E-01 1.46E-01 3.77E-01

1.04 0.88 0.98

7.33E-01 5.31E-02 5.22E-01

1.02 0.62 0.78

1.18E-01 2.14E-02 7.20E-02

1.07 0.32

3.63E-01 2.26E-04

1.13 1.26

5.28E-01 1.66E-01

1.09 1.97

3.26E-01 3.76E-01

1.70 0.92 0.82 0.77 0.53 0.73 0.33 0.24 0.28 0.60 1.00 0.73 1.34 1.24 1.04 1.03 1.04 0.92


0.94 1.00 1.02 1.19 1.07 1.27 1.65 1.36 1.81 0.76 0.80 2.46 1.02 1.14 1.69 1.88 1.25 1.12


1.04 0.96 5.39 5.74 5.86 1.16 3.81 4.02 3.05 1.03 0.76 11.82 0.28 0.57 1.11 0.97 1.45 1.27


1.14

5.41E-01

1.38

1.14E-01

0.99

6.37E-01

MSMEG_4544 methyltransferase small domain superfamily protein MSMEG_4545 bacterial extracellular solute-binding protein, family protein 5 MSMEG_4546 oxidoreductase; this gene contains a frame shift which is not the result of sequencing error MSMEG_4547 acyl-CoA dehydrogenase family protein MSMEG_4548 acetyltransferase, gnat family protein MSMEG_4549 amino acid permease-associated region, putative MSMEG_4551 monoxygenase ssuD MSMEG_4552 nitrilotriacetate monooxygenase component A MSMEG_4553 GAF domain, putative MSMEG_4554 probable serine/threonine-protein kinase PknH, putative MSMEG_4555 LppR protein lepA MSMEG_4556 GTP-binding protein LepA MSMEG_4557 ABC transporter, ATP-binding protein MSMEG_4558 conserved hypothetical protein MSMEG_4559 ABC transporter, membrane spanning protein MSMEG_4560 periplasmic binding protein MSMEG_4561 ABC Fe3+-siderophores transporter, periplasmic binding protein MSMEG_4562 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_4563 puromycin N-acetyltransferase MSMEG_4564 CBS domain protein MSMEG_4565 oxidoreductase MSMEG_4566 conserved 13e12 repeat family protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_4566 conserved 13e12 repeat family protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_4567 conserved hypothetical protein MSMEG_4568 ribonuclease Z MSMEG_4569 conserved hypothetical protein MSMEG_4570 conserved hypothetical protein

0.79

3.15E-01

0.95

6.39E-01

1.19

1.14E-01

1.29

1.07E-01

1.15

2.28E-01

0.95

3.24E-01

2.52 1.03 0.92 1.28 1.03 1.00 1.22

2.83E-02 9.02E-01 5.48E-01 2.28E-01 6.49E-01 9.56E-01 1.05E-01

2.10 1.04 1.45 1.46 1.17 1.53 1.00

2.10E-01 7.48E-01 2.61E-01 1.21E-01 1.67E-01 7.70E-02 9.83E-01

0.90 1.12 1.01 2.36 1.01 1.24 0.53

1.77E-01 1.86E-01 1.62E-01 3.49E-01 7.81E-01 4.20E-01 5.82E-03

2.07 1.11 0.67 0.27 2.39 0.33 0.31

1.95E-02 5.87E-01 1.23E-03 1.94E-05 7.38E-04 4.05E-05 1.30E-05

1.09 1.42 0.83 0.93 0.82 0.85 1.01

4.56E-01 3.74E-01 2.38E-01 5.71E-01 9.30E-02 9.76E-02 9.08E-01

1.05 0.94 1.19 3.14 1.00 1.76 2.26

4.03E-01 2.43E-01 3.56E-02 1.68E-01 9.82E-01 1.13E-01 9.21E-02

0.35

4.65E-05

0.85

1.62E-01

2.32

2.30E-01

1.54 0.75 1.14 1.56

1.23E-01 1.56E-02 1.48E-01 6.98E-02

1.47 1.04 0.92 1.12

3.01E-01 5.35E-01 3.96E-01 3.51E-01

0.93 1.02 0.51 0.93

4.74E-01 8.85E-01 9.04E-04 1.71E-01

1.41

2.79E-02

1.27

1.93E-01

1.86

1.72E-01

1.21 0.57 2.68 0.68 0.55

1.98E-01 4.42E-06 7.80E-02 7.14E-03 2.02E-03

1.05 1.12 1.05 0.90 0.96

6.82E-01 3.76E-01 5.11E-01 1.08E-02 7.67E-01

1.16 0.82 0.23 1.01 0.60

4.83E-01 1.59E-01 3.92E-04 9.40E-01 6.01E-03


ribosomal protein S20 DNA polymerase III, delta subunit competence protein DNA-binding protein hypothetical protein SpfH domain protein DegV family protein conserved hypothetical protein phosphoglycerate mutase family protein conserved domain protein nicotinate (nicotinamide) nucleotide adenylyltransferase conserved hypothetical protein conserved hypothetical protein ATPase associated with various cellular activities gamma-glutamyl phosphate reductase ribokinase ABC nitrate/sulfonate/bicarbonate family protein transporter, periplasmic ligand binding protein putative aliphatic sulfonates transport ATPbinding protein SsuB ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit rhodanese domain protein/cystathionine betalyase nitrilotriacetate monooxygenase component A hypothetical protein acyl-CoA dehydrogenase family protein acyl-CoA dehydrogenase hypothetical protein probable serine/threonine-protein kinase PknH, putative hypothetical protein putative conserved lipoprotein lpph putative conserved lipoprotein lpph hypothetical protein hypothetical protein transcriptional regulator, AraC family protein

rpsT

1.47 0.82 1.06 1.01 2.10 7.95 0.50 0.45 0.60 0.59

1.41E-03 1.97E-01 6.26E-01 9.09E-01 8.88E-03 1.17E-02 2.16E-02 1.33E-04 1.21E-03 7.69E-04

0.76 1.01 1.38 1.01 0.88 0.84 1.47 1.20 0.91 0.99

1.94E-02 8.57E-01 2.05E-01 9.58E-01 4.82E-01 5.41E-01 4.54E-02 3.28E-01 3.43E-01 8.49E-01

0.76 1.23 1.06 0.89 2.33 2.15 1.32 1.56 2.30 2.11

1.21E-03 3.52E-01 6.86E-01 4.09E-01 1.05E-01 2.19E-01 3.96E-01 1.54E-01 1.94E-02 1.91E-03

nadD

0.66 1.31 0.89 0.97 1.14 1.31

1.20E-03 9.42E-02 2.00E-01 7.41E-01 5.80E-02 5.71E-02

1.05 0.84 0.99 0.82 0.93 0.95

3.67E-01 9.44E-02 8.78E-01 9.21E-03 5.69E-01 7.54E-01

1.35 0.93 1.11 0.84 0.84 1.24

1.36E-03 2.82E-01 2.89E-01 9.02E-02 1.07E-01 2.39E-01

1.46

6.65E-02

2.67

2.80E-01

2.97

9.44E-02

1.62

9.39E-02

2.46

2.16E-01

1.29

3.44E-01

1.43

4.44E-03

2.38

3.23E-01

1.82

1.88E-01

1.45 1.83 1.68 1.53 0.73 1.92

1.04E-01 6.67E-02 2.45E-02 6.83E-02 1.60E-02 5.24E-02

2.80 2.42 1.08 2.92 2.97 0.91

2.67E-01 2.96E-01 4.95E-01 1.88E-01 3.04E-01 4.84E-01

2.06 1.44 3.59 1.32 1.05 1.01

6.84E-02 1.75E-01 2.28E-01 1.45E-01 2.09E-01 9.09E-01

0.71 0.72 0.68 0.92 1.24 1.19 4.63

3.28E-03 2.38E-03 1.07E-02 1.03E-01 6.37E-02 3.07E-01 3.17E-01

1.34 1.23 1.25 1.14 1.32 0.84 1.06

2.59E-02 1.26E-01 5.53E-03 1.44E-01 1.89E-01 8.76E-02 5.19E-01

0.71 0.70 1.67 0.75 1.19 0.93 0.95

6.66E-02 6.56E-02 9.55E-02 2.82E-02 2.12E-01 6.62E-01 7.02E-01

proA rbsK

ssuD

lppH lppH

MSMEG_4602 hypothetical protein MSMEG_4603 integral membrane protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01925 MSMEG_4604 hypothetical protein MSMEG_4605 ankyrin; this gene contains a premature stop which is not the result of sequencing error MSMEG_4605 ankyrin; this gene contains a premature stop which is not the result of sequencing error MSMEG_4606 hypothetical protein MSMEG_4606 hypothetical protein MSMEG_4607 hypothetical protein MSMEG_4609 transcriptional regulator LysR family protein MSMEG_4610 IgiC, putative MSMEG_4611 carrier protein MSMEG_4612 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF04978 MSMEG_4612 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF04978 MSMEG_4613 hypothetical protein MSMEG_4614 GAF family protein MSMEG_4615 replicative DNA helicase; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_4615 replicative DNA helicase; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_4616 acyl-CoA dehydrogenase family protein; this gene contains a frame shift which is not the result of sequencing error nadE MSMEG_4617 glutamine-dependent NAD+ synthetase MSMEG_4618 isochorismatase family protein MSMEG_4619 putative cytochrome P450 126

1.39

5.59E-02

0.98

8.41E-01

1.14

2.52E-01

0.74 0.57

3.30E-02 5.71E-02

1.10 1.10

3.17E-01 1.12E-01

1.48 3.80

1.11E-01 2.26E-01

0.62

5.32E-03

1.20

5.34E-02

3.22

7.44E-03

0.95 1.67 1.11 1.30 0.98 1.86 1.54

4.73E-01 8.71E-02 3.42E-01 9.43E-02 9.05E-01 3.68E-02 7.14E-03

0.99 1.11 0.92 1.19 1.08 0.97 0.94

9.13E-01 1.94E-01 3.66E-01 1.58E-01 1.45E-01 6.75E-01 6.89E-01

2.21 2.00 1.01 0.79 0.94 0.70 0.99

1.35E-02 1.77E-01 9.13E-01 2.20E-01 3.51E-01 3.95E-02 9.55E-01

0.58

2.45E-03

1.24

1.21E-02

0.97

2.80E-01

0.72 1.34 0.74

8.42E-03 3.13E-02 1.78E-03

1.01 1.12 1.09

8.41E-01 1.95E-01 4.58E-01

1.50 1.32 0.94

3.61E-01 2.10E-01 7.65E-01

0.88

1.01E-01

1.38

6.25E-03

1.46

1.24E-01

2.37

1.85E-01

1.09

8.51E-02

0.98

9.41E-01

1.20 1.04 1.34 1.51

1.86E-01 6.48E-01 3.52E-01 2.92E-02

1.21 0.66 2.00 1.02

4.59E-03 2.77E-03 5.67E-02 8.98E-01

1.00 2.19 0.87 1.17

9.07E-01 1.46E-01 5.40E-01 4.51E-01


MSMEG_4630 MSMEG_4631 MSMEG_4632 MSMEG_4633 MSMEG_4634 MSMEG_4635 MSMEG_4636 MSMEG_4637 MSMEG_4638 MSMEG_4639 MSMEG_4640 MSMEG_4641 MSMEG_4642 MSMEG_4643 MSMEG_4644 MSMEG_4645 MSMEG_4646 MSMEG_4647 MSMEG_4648 MSMEG_4649 MSMEG_4650 MSMEG_4651

NAD-dependent deacetylase 1 glutamate 5-kinase transcriptional regulator, TetR family protein GTP-binding protein Obg/CgtA ribosomal protein L27 ribosomal protein L21 ribonuclease, Rne/Rng family protein nucleoside diphosphate kinase conserved hypothetical protein FolC bifunctional protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499 valyl-tRNA synthetase conserved hypothetical protein saccharopine dehydrogenase peptidase S9, prolyl oligopeptidase hypothetical protein ammonium transporter family protein hypothetical protein conserved hypothetical protein vanillate O-demethylase oxidoreductase conserved hypothetical protein secreted protein salicylate hydroxylase hypothetical protein resuscitation-promoting factor molybdopterin-guanine dinucleotide biosynthesis protein A alpha oxoglutarate ferredoxin oxidoreductase, beta subunit pyruvate synthase carbohydrate kinase, PfkB, putative DNA-binding protein phytanoyl-CoA dioxygenase hypothetical oxidoreductase YisS AP endonuclease, family protein 2

proB rpmA rplU

folC valS

orB

1.91 0.75 1.27 0.95 1.02 0.97 0.82 0.41 0.39

5.69E-03 6.71E-03 3.64E-02 6.97E-01 3.04E-01 6.36E-01 6.38E-04 1.14E-04 2.85E-04

0.82 0.76 1.58 0.73 0.83 0.77 0.86 0.81 0.92

1.13E-01 7.05E-02 4.29E-01 3.77E-03 2.42E-01 7.99E-02 5.05E-02 7.97E-02 3.35E-01

1.36 0.92 2.14 1.01 0.62 0.72 1.24 0.57 2.06

2.56E-02 5.02E-01 3.60E-01 9.21E-01 2.62E-02 1.01E-02 1.90E-01 2.48E-03 2.90E-03

0.85 0.53 1.27 0.85 0.97 0.85 0.10 0.48 0.35 0.24 0.29 1.46 0.81 1.12 0.79


1.30 1.13 0.79 0.86 0.99 1.34 2.52 1.59 1.73 1.33 1.30 0.93 0.83 1.11 1.26


1.54 2.42 1.28 1.50 0.95 1.22 0.60 1.04 1.02 1.02 1.67 0.74 1.03 1.17 1.19


1.46

4.62E-03

1.18

2.84E-01

0.83

1.83E-01

1.35 1.69 0.58 1.31 2.23 2.70 2.51

3.11E-02 4.36E-03 6.51E-04 4.33E-01 7.90E-03 6.68E-04 1.07E-02

0.91 0.76 0.81 1.41 1.32 1.06 1.38

1.53E-01 5.30E-02 1.50E-01 1.01E-01 2.61E-01 6.60E-01 2.40E-01

4.13 3.57 2.83 0.95 0.88 0.62 0.92

2.05E-02 2.86E-03 6.10E-03 5.85E-01 1.89E-01 1.08E-02 3.18E-01

MSMEG_4652 D-oliose 4-ketoreductase MSMEG_4653 AP endonuclease, family protein 2 superfamily protein MSMEG_4654 aldo/keto reductase MSMEG_4655 transcriptional regulator, AraC family protein MSMEG_4656 sugar ABC transporter ATP-binding protein MSMEG_4657 ABC transporter membrane protein MSMEG_4658 sugar ABC transporter substrate-binding protein MSMEG_4659 GntR-family protein transcriptional regulator MSMEG_4660 hypothetical protein MSMEG_4661 sugar kinase, ribokinase family protein MSMEG_4662 deoxyribose-phosphate aldolase superfamily protein MSMEG_4663 protein IolB MSMEG_4664 IolD protein MSMEG_4665 IolE protein MSMEG_4666 myo-inositol 2-dehydrogenase MSMEG_4667 transcriptional regulator, LysR family protein MSMEG_4668 oxidoreductase alpha (molybdopterin) subunit MSMEG_4669 formate dehydrogenase family protein accessory protein FdhD MSMEG_4670 N-glycosylation MSMEG_4671 ATP-dependent Clp protease, ATP-binding subunit ClpX MSMEG_4672 Clp protease MSMEG_4673 Clp protease MSMEG_4674 trigger factor MSMEG_4677 hypothetical protein MSMEG_4678 hypothetical protein MSMEG_4679 hypothetical protein MSMEG_4680 carboxylesterase, putative MSMEG_4681 conserved hypothetical protein MSMEG_4682 Na+/H+ antiporter MSMEG_4683 putative formamidopyrimidine-DNA glycosylase MSMEG_4684 ribose 5-phosphate isomerase MSMEG_4685 oxidoreductase MSMEG_4686 putative oxidoreductase YdbC MSMEG_4687 cytosine deaminase

2.23

3.66E-03

0.74

7.44E-02

0.92

1.58E-01

2.32 4.47 1.36 3.61 4.53 3.49 2.27 1.33 3.35

1.47E-02 1.81E-02 3.10E-02 4.14E-03 2.76E-03 1.71E-03 1.47E-03 5.73E-02 2.12E-03

0.73 0.60 1.16 1.10 0.80 0.97 0.77 1.06 0.87

6.38E-02 1.29E-02 4.02E-01 5.13E-01 1.45E-01 7.78E-01 1.58E-02 6.28E-01 3.38E-01

1.48 0.95 0.86 0.17 0.09 0.11 0.79 1.11 0.87

1.85E-01 6.61E-01 1.63E-01 3.83E-05 8.59E-08 4.57E-06 2.96E-02 3.65E-01 3.86E-01

4.50 5.97 4.24 4.19 2.85 1.77 1.93

1.79E-03 2.29E-03 2.05E-03 1.53E-03 2.71E-02 3.38E-03 8.32E-03

0.81 0.76 0.68 0.76 0.71 0.96 0.80

1.61E-01 9.01E-02 2.16E-02 6.90E-02 6.60E-02 4.65E-01 6.87E-02

1.93 0.84 0.73 0.76 1.15 1.20 0.74

4.83E-01 2.42E-01 7.42E-03 6.74E-02 3.79E-01 5.08E-01 4.11E-02

fdhD

1.08 1.26

3.70E-01 3.53E-01

1.11 1.22

4.32E-01 1.64E-01

1.08 0.89

6.40E-01 2.66E-01

clpX clpP clpP tig

2.43 1.17 1.20 0.63 0.72 0.74 0.59 1.22 1.93 0.76 0.82 0.70 0.70 0.77 0.89


0.92 0.73 0.88 0.82 1.21 1.12 1.12 0.69 0.82 0.96 1.29 1.06 0.91 0.69 0.99


1.03 0.82 0.87 1.18 1.10 0.56 0.94 0.94 1.06 0.54 1.49 0.77 0.67 0.87 0.36


lipP


conserved hypothetical protein, putative conserved hypothetical protein pepN aminopeptidase N HNH nuclease conserved hypothetical protein conserved hypothetical protein HNH endonuclease family protein protozoan/cyanobacterial globin family protein alpha-amylase family protein conserved hypothetical protein conserved hypothetical protein NAD-glutamate dehydrogenase ABC-transporter protein, ATP binding component


single-strand binding protein ABC-type transporter, permease components glycerol-3-phosphate acyltransferase acyltransferase family protein acyltransferase, ws/dgat/mgat subfamily protein non-heme bromoperoxidase BPO-A2 putative methyltransferase enoyl-CoA hydratase dihydrolipoamide acetyltransferase pyruvate dehydrogenase E1 component subunit beta pyruvate dehydrogenase E1 component, alpha subunit HpcH/HpaI aldolase/citrate lyase family protein MoaC domain protein acyl-CoA dehydrogenase acetyl-/propionyl-coenzyme A carboxylase alpha chain Carboxyl transferase domain protein transcriptional regulator, TetR family protein peptidase S9, prolyl oligopeptidase conserved hypothetical protein permease of the major facilitator superfamily protein


2.28 1.71 0.41 0.54 0.30 0.39 3.20 1.70 0.95 0.28 0.61 0.76

3.01E-02 1.70E-02 1.25E-05 1.33E-02 4.23E-07 1.29E-05 2.98E-06 8.38E-04 6.48E-01 9.10E-04 6.83E-03 5.72E-03

0.75 0.68 0.99 0.92 0.89 0.87 0.87 0.91 0.90 1.21 0.81 0.91

7.22E-02 6.57E-02 8.68E-01 4.53E-01 3.68E-01 1.47E-02 2.06E-01 3.40E-01 7.24E-02 1.22E-01 1.02E-01 2.12E-01

0.41 0.44 0.87 1.22 0.73 0.64 0.53 0.90 1.72 1.44 1.48 1.59

9.10E-04 3.62E-03 2.94E-02 2.25E-01 3.92E-02 2.24E-02 9.37E-04 6.28E-01 4.72E-02 2.04E-01 1.27E-01 9.11E-02

0.72 1.05 0.67 0.80 0.98 1.27 0.81 1.01 0.60 8.15

7.18E-03 7.74E-01 2.97E-04 2.77E-03 8.21E-01 1.51E-01 4.46E-01 9.17E-01 5.50E-05 5.62E-02

1.14 6.42 0.83 0.92 0.89 0.92 1.19 0.80 0.85 1.08

2.75E-01 1.39E-01 8.42E-03 1.04E-01 1.47E-01 1.40E-01 1.19E-01 1.32E-02 8.55E-02 7.79E-01

1.19 1.25 3.55 1.02 1.45 1.77 1.02 1.85 1.38 1.39

5.06E-02 4.36E-01 1.09E-02 4.99E-01 3.02E-01 1.38E-01 7.58E-01 1.69E-01 2.19E-02 2.23E-02

11.36

2.73E-02

0.89

6.71E-01

1.06

5.88E-01

5.39 1.25 1.39 1.64

2.72E-03 2.79E-02 1.35E-02 9.96E-04

1.19 0.94 1.02 0.97

3.55E-01 3.96E-01 7.07E-01 4.65E-01

0.58 1.65 1.88 1.61

1.00E-03 7.24E-02 9.84E-02 2.15E-01

1.44 1.05 1.58 0.73 1.51

3.92E-03 4.81E-01 1.31E-01 2.66E-02 7.23E-03

0.92 2.31 1.00 0.86 0.80

3.99E-01 1.18E-01 9.74E-01 1.39E-02 1.21E-01

2.04 1.06 1.11 1.25 1.61

1.80E-01 5.62E-01 7.37E-01 2.96E-01 2.45E-02

0.66

2.15E-02

0.75

4.36E-02

1.14

5.59E-01


short-chain dehydrogenase conserved hypothetical protein oligoribonuclease carbamoyl-phosphate synthase small chain mycocerosic acid synthase condensation domain protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein acyl-CoA synthase glycosyl transferase, group 2 family protein, putative putative membrane protein hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein conserved hypothetical protein Glycosyltransferase family protein 28 MmpL protein clavaldehyde dehydrogenase conserved hypothetical protein conserved hypothetical protein ErfK/YbiS/YcfS/YnhG family protein hypothetical protein hypothetical protein hypothetical protein ornithine carbamoyltransferase hypothetical protein conserved hypothetical protein antioxidant, AhpC/TSA family protein K+-dependent Na+/Ca+ exchanger relatedpeptidase M20 holo-(acyl-carrier-protein) synthase fatty acid synthase hypothetical protein hypothetical protein

acpS

0.56 0.59 0.72 1.13 0.66 0.57 0.50 0.77 0.47 0.65

3.81E-04 3.23E-04 4.05E-03 3.56E-01 1.53E-01 3.70E-02 6.95E-04 7.16E-03 9.47E-03 1.44E-02

0.84 0.69 0.99 1.07 1.15 0.97 1.05 0.70 1.04 0.93

9.29E-02 4.63E-03 8.94E-01 3.22E-01 4.95E-01 7.83E-01 6.96E-01 1.04E-03 5.59E-01 5.46E-01

1.02 0.55 0.84 1.04 1.00 1.12 1.05 0.87 1.02 2.74

8.88E-01 5.03E-03 9.10E-02 5.84E-01 9.77E-01 7.05E-01 2.23E-01 7.30E-02 2.11E-01 5.79E-03

1.11 0.58 0.43 0.55 0.74 1.54 1.04 1.17 1.46 1.47 0.78 2.75 2.14 1.01 1.05 4.76 0.60 0.55 2.03 0.60 0.86 0.26 0.53 0.26 0.34 1.47 1.19


1.06 0.81 0.82 0.85 1.03 0.99 0.98 0.66 0.80 0.64 0.81 1.01 1.13 0.96 1.08 1.18 1.29 1.29 1.02 0.97 0.82 1.15 0.85 1.08 0.69 1.32 0.89


1.13 1.75 1.73 1.22 3.46 1.20 1.41 1.16 1.07 1.49 0.40 0.38 0.47 1.61 2.18 0.66 1.06 0.95 1.23 1.27 1.07 1.89 1.23 1.83 1.51 1.34 1.04


MSMEG_4760 conserved hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_4761 ABC transporter ATP-binding protein MSMEG_4762 ABC transporter binding protein MSMEG_4763 ABC transporter permease protein MSMEG_4764 ABC transporter permease protein MSMEG_4765 transcriptional regulator, MerR family protein ltrA MSMEG_4766 low temperature requirement protein LtrA MSMEG_4767 major facilitator superfamily protein permease MSMEG_4768 transcriptional regulator MSMEG_4769 conserved hypothetical protein MSMEG_4770 conserved hypothetical protein MSMEG_4771 conserved hypothetical protein MSMEG_4772 acyl-CoA synthase MSMEG_4773 amidohydrolase family protein MSMEG_4774 AMP-dependent synthetase and ligase MSMEG_4775 enoyl-CoA hydratase/isomerase family protein MSMEG_4776 glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_4777 conserved hypothetical protein MSMEG_4778 putative thiolase MSMEG_4779 probable regulatory protein MSMEG_4780 cytochrome p450 MSMEG_4781 conserved hypothetical protein MSMEG_4781 conserved hypothetical protein MSMEG_4782 conserved hypothetical protein MSMEG_4783 conserved hypothetical protein MSMEG_4784 conserved hypothetical protein MSMEG_4785 mce-family protein mce1f MSMEG_4786 virulence factor mce family protein MSMEG_4787 virulence factor mce family protein MSMEG_4788 virulence factor mce family protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_4789 hypothetical protein

1.39 0.66 0.60 0.65 2.55 1.20 0.81 0.37 6.10 7.18 0.96 1.07 1.71 3.07 2.27 0.95


1.16 0.96 0.90 0.91 0.94 1.10 0.91 0.98 0.37 0.85 0.88 0.90 0.91 0.67 0.86 0.87


1.11 1.45 0.89 0.90 0.92 1.35 1.80 9.11 0.92 0.92 1.43 0.95 1.51 0.56 1.00 0.89


1.65 1.97 1.99 0.71 17.52 8.03 9.18 4.76 4.43 6.52 1.36 0.88 1.17

3.66E-02 1.25E-02 1.92E-01 2.32E-03 1.98E-02 3.50E-04 9.21E-04 1.01E-02 8.82E-03 8.33E-03 3.64E-02 2.03E-01 5.96E-01

1.27 0.74 0.86 0.94 0.53 0.48 0.57 0.57 0.71 0.52 1.00 1.49 1.63

2.60E-01 1.12E-02 6.23E-02 6.00E-01 3.45E-02 1.62E-02 2.75E-02 2.19E-02 2.03E-02 2.93E-02 9.28E-01 1.77E-01 5.35E-02

1.09 0.72 0.79 0.93 0.17 0.22 0.75 0.77 0.94 0.87 0.94 0.96 1.06

3.53E-01 1.63E-02 2.02E-01 2.44E-01 2.49E-05 2.20E-05 8.90E-02 9.57E-02 3.64E-01 1.49E-01 2.75E-01 1.43E-01 3.45E-01

0.71 1.09

5.72E-02 1.74E-01

0.86 1.01

4.11E-01 8.81E-01

0.86 0.91

1.05E-01 7.44E-01


IS1096, tnpR protein IS1096, tnpR protein virulence factor mce family protein virulence factor Mce family protein virulence factor ABC-transporter integral membrane protein conserved hypothetical protein hypothetical protein L-carnitine dehydratase/bile acid-inducible protein F aldehyde dehydrogenase (NAD) family protein 3-oxoacyl-(acyl-carrier-protein) reductase, carveol dehydrogenase conserved domain protein cytochrome P450 superfamily protein conserved hypothetical protein acyl-CoA dehydrogenase putative acyl-CoA dehydrogenase amidohydrolase family protein amidohydrolase family protein Rieske [2Fe-2S] domain, putative conserved hypothetical protein conserved hypothetical protein respiratory-chain NADH dehydrogenase domain, 51 kda subunit conserved domain protein conserved hypothetical protein conserved hypothetical protein 6-phosphogluconate dehydrogenase, NADbinding 6-phosphogluconate dehydrogenase, NADbinding putative cytochrome P450 123 conserved domain protein conserved hypothetical protein conserved hypothetical protein conserved domain protein cytochrome p450

1.47 0.86 3.84 3.11 1.75 1.10 1.39 3.54

8.75E-02 2.10E-01 8.84E-03 1.53E-02 3.25E-02 5.95E-01 8.59E-02 2.13E-02

0.65 1.03 0.93 0.62 0.96 0.86 0.77 0.89

4.70E-02 5.42E-01 7.55E-01 1.05E-02 5.84E-01 2.06E-01 5.71E-02 4.03E-01

0.64 1.63 0.99 0.96 1.10 0.89 0.79 0.96

5.83E-03 1.42E-02 6.20E-01 3.03E-01 7.33E-01 5.13E-01 5.16E-01 7.49E-01

1.92 3.27 1.18 2.77 2.59 1.89 2.35 1.85 1.29 1.56 2.20 1.38 1.80 1.44

1.32E-01 8.84E-04 4.30E-01 2.66E-02 1.79E-02 9.10E-02 2.02E-02 1.03E-01 3.06E-01 1.26E-01 1.42E-02 3.42E-02 2.64E-02 1.61E-01

1.10 0.91 1.15 0.91 0.72 0.79 0.88 1.01 1.08 0.81 1.06 0.95 0.88 0.88

6.28E-01 2.63E-01 3.59E-01 3.79E-01 5.31E-02 3.21E-03 6.04E-01 8.45E-01 2.92E-01 1.27E-02 3.67E-01 5.35E-01 1.88E-01 4.16E-01

1.00 1.18 1.03 1.14 1.28 1.13 0.62 1.18 0.80 2.72 0.94 0.99 1.77 1.41

9.48E-01 1.30E-01 6.12E-01 6.04E-01 5.46E-01 6.04E-01 1.39E-02 3.21E-01 4.21E-02 3.88E-01 4.48E-01 6.82E-01 3.26E-01 2.10E-01

1.35 1.52 1.94 1.67

1.27E-01 5.73E-02 1.04E-01 8.50E-02

0.96 0.89 0.96 0.91

4.38E-01 5.44E-01 5.38E-01 4.81E-01

1.39 1.12 1.14 1.00

2.26E-01 2.12E-01 1.91E-01 9.90E-01

1.17

2.13E-01

1.05

2.92E-01

1.33

1.82E-01

1.24 1.59 2.02 2.53 3.19 2.41 1.89

3.73E-01 1.59E-01 1.55E-02 2.76E-01 1.33E-02 5.15E-02 3.28E-04

1.25 0.89 1.09 1.13 0.95 1.01 1.06

5.48E-01 2.83E-01 6.29E-01 1.61E-01 8.89E-01 8.70E-01 7.39E-01

1.18 1.13 1.54 1.18 0.97 0.93 1.01

3.10E-01 5.87E-01 4.15E-01 1.61E-01 2.38E-01 3.73E-01 9.56E-01

MSMEG_4824 hypothetical protein MSMEG_4825 transcriptional repressor, TetR family protein, putative MSMEG_4826 putative acyl-CoA dehydrogenase MSMEG_4827 aminoglycoside phosphotransferase MSMEG_4828 alcohol dehydrogenase, zinc-binding MSMEG_4829 cytochrome P450 MSMEG_4830 conserved hypothetical protein MSMEG_4831 transcriptional regulator, TetR family protein MSMEG_4832 acyl-CoA dehydrogenase MSMEG_4833 putative acyl-CoA dehydrogenase MSMEG_4834 L-carnitine dehydratase/bile acid-inducible protein F MSMEG_4835 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4836 FadE12_1 MSMEG_4837 amidohydrolase 2 MSMEG_4838 hypothetical protein MSMEG_4839 carboxymuconolactone decarboxylase MSMEG_4840 Rieske [2Fe-2S] domain protein MSMEG_4841 conserved hypothetical protein MSMEG_4842 amidohydrolase MSMEG_4843 conserved hypothetical protein MSMEG_4844 acyl-CoA dehydrogenase MSMEG_4845 putative acyl-CoA dehydrogenase MSMEG_4846 probable enoyl-CoA hydratase MSMEG_4847 transcriptional regulator, TetR family protein MSMEG_4848 hypothetical protein MSMEG_4849 carveol dehydrogenase MSMEG_4850 short-chain dehydrogenase/reductase SDR MSMEG_4851 caib/baif family protein MSMEG_4852 enoyl-CoA hydratase, putative MSMEG_4853 peptidase, M24 family protein MSMEG_4854 peptidase, M24 family protein MSMEG_4855 amidohydrolase family protein MSMEG_4856 cytochrome P450 MSMEG_4857 conserved domain protein MSMEG_4858 transcriptional regulator, TetR family protein

1.35

1.08E-01

1.04

7.42E-01

0.85

2.55E-01

1.41 1.31 1.45 0.81 2.50 3.14 2.02 1.41 1.49

1.44E-01 4.61E-02 1.53E-02 1.55E-01 2.70E-02 8.17E-03 3.18E-02 7.47E-03 1.01E-03

0.96 0.93 0.72 1.05 0.77 1.07 0.91 0.93 0.80

7.82E-01 4.41E-01 2.45E-02 7.87E-01 2.41E-02 6.31E-01 6.05E-01 6.53E-01 5.70E-02

1.02 0.66 1.09 1.14 0.67 0.24 0.31 1.09 1.16

8.96E-01 2.55E-02 8.63E-01 4.26E-01 4.52E-02 6.59E-06 1.14E-03 3.66E-01 1.81E-01

1.05 1.37 2.33 2.00 1.04 1.44 2.01 1.50 2.39 1.77 2.60 1.16 1.08 1.17 0.70 4.37 2.73 0.84 0.70 2.09 1.09 1.29 1.41 1.15 0.94


0.83 0.95 0.60 0.77 1.17 0.90 0.68 1.12 0.87 1.05 1.03 0.85 0.90 0.87 1.25 0.87 0.83 1.04 0.95 1.47 0.92 1.03 0.98 1.31 1.02


1.64 1.04 1.15 0.87 1.72 1.05 0.86 0.95 1.02 1.42 1.00 1.37 1.03 0.81 1.38 0.31 1.02 1.03 1.08 0.35 0.82 1.23 0.86 0.92 1.12


MSMEG_4859 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_4860 hydrolase, alpha/beta fold family protein, putative MSMEG_4861 cyclase MSMEG_4862 3-alpha-hydroxysteroid dehydrogenase MSMEG_4863 conserved hypothetical protein MSMEG_4864 3-ketosteroid dehydrogenase MSMEG_4865 metapyrocatechase 1 MSMEG_4866 3-(3-hydroxy-phenyl)propionate hydroxylase MSMEG_4867 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase MSMEG_4868 transcriptional regulator, IclR family protein, Cdomain protein MSMEG_4869 LAO/AO transport system ATPase MSMEG_4870 FAD binding domain, putative MSMEG_4871 3-hydroxyacyl-CoA dehydrogenase type-2 MSMEG_4872 short chain dehydrogenase MSMEG_4873 enoyl-CoA hydratase/isomerase MSMEG_4874 putative acyl-CoA dehydrogenase MSMEG_4875 putative acyl-CoA dehydrogenase MSMEG_4876 acyl-CoA synthase MSMEG_4877 CaiB/BaiF family protein MSMEG_4878 2Fe-2S iron-sulfur cluster binding domain protein MSMEG_4879 conserved hypothetical protein MSMEG_4880 methylmalonyl-CoA mutase C-terminal domain protein MSMEG_4881 methylmalonyl-CoA mutase, N-terminus of large subunit MSMEG_4882 short chain dehydrogenase MSMEG_4883 AMP-dependent synthetase and ligase MSMEG_4884 conserved hypothetical protein MSMEG_4885 conserved hypothetical protein MSMEG_4886 major facilitator family protein transporter MSMEG_4887 cytochrome P450 MSMEG_4888 periplasmic binding proteins and sugar binding domain of the LacI family protein, putative MSMEG_4889 integral membrane transport protein ahpD MSMEG_4890 alkylhydroperoxidase, AhpD family protein

1.41 3.64 3.04 1.42 1.43 1.33 0.85 1.29

2.98E-03 3.42E-01 3.64E-01 3.19E-01 2.81E-03 1.53E-01 9.49E-02 1.32E-01

0.95 1.18 1.10 1.08 1.00 0.91 0.94 0.94

4.90E-01 4.41E-01 6.27E-01 2.27E-01 9.76E-01 3.74E-01 1.32E-01 4.38E-01

0.98 1.08 0.98 1.47 1.22 0.96 1.14 1.13

6.60E-01 4.32E-01 4.42E-01 3.56E-01 5.58E-01 3.55E-01 1.61E-01 9.51E-02

1.26

1.51E-01

0.97

5.45E-01

1.06

5.31E-01

1.85 1.39 0.95 2.04 0.90 1.38 1.19 1.14 1.03 1.88 1.29 1.66

1.68E-01 4.88E-02 4.75E-01 1.03E-01 3.01E-01 2.80E-02 1.41E-01 4.40E-01 8.19E-01 9.91E-02 2.71E-01 2.91E-02

1.28 0.96 1.56 1.25 1.99 0.99 1.00 1.11 0.99 0.94 1.10 0.88

1.02E-01 7.99E-01 3.77E-01 4.98E-01 2.08E-01 9.37E-01 1.00E+00 7.20E-01 8.68E-01 2.76E-01 2.14E-01 2.52E-01

0.94 0.79 1.14 1.02 0.98 0.95 1.38 0.99 1.09 1.02 0.99 1.10

3.15E-01 2.10E-01 3.57E-01 4.86E-01 8.89E-01 6.32E-01 4.03E-01 8.97E-01 3.65E-01 8.46E-01 9.55E-01 1.90E-01

0.87

9.48E-02

1.16

7.01E-02

1.09

4.92E-01

2.44 1.59 1.13 1.56 1.04 1.21 1.36

2.02E-01 2.17E-01 4.81E-01 5.42E-02 8.99E-01 2.72E-01 4.36E-01

2.08 1.02 1.62 1.03 1.13 1.08 0.98

2.76E-01 7.46E-01 3.06E-01 7.33E-01 1.73E-01 5.42E-01 8.06E-01

1.12 0.92 1.79 1.04 0.98 0.95 0.99

5.01E-01 1.69E-01 3.84E-01 2.18E-01 3.17E-01 1.88E-01 7.78E-01

1.54 1.01 0.16

1.37E-02 9.56E-01 1.06E-07

0.93 1.22 0.80

5.08E-01 2.38E-01 3.01E-01

1.18 0.95 16.32

4.73E-01 5.02E-01 3.21E-02


alkylhydroperoxide reductase conserved hypothetical protein Putative neutral zinc metallopeptidase conserved hypothetical protein hypothetical protein non-ribosomal peptide synthetase conserved hypothetical protein non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein Pks14 protein ribonuclease PH metal-dependent hydrolase of the beta-lactamase superfamily protein III glutamate racemase rhomboid family protein cysteine synthase B ThiS family protein Mov34/MPN/PAD-1 family protein endo-type 6-aminohexanoate oligomer hydrolase conserved hypothetical protein ATP-dependent Clp protease adaptor protein ClpS

rdgB rph murI cysM

pncB putative nicotinate phosphoribosyltransferase putative helicase LpqM protein virginiamycin B hydrolase alpha-glucan phosphorylase family protein alpha-amylase family protein tetratricopeptide repeat domain protein glgB 1,4-alpha-glucan branching enzyme conserved hypothetical protein acetyl-CoA acetyltransferase mce methylmalonyl-CoA epimerase conserved hypothetical protein conserved hypothetical protein adenylate cyclase, family protein 3 transcriptional regulator, Ada family protein/DNA3-methyladenine glycosylase II

0.10 0.79 0.99 0.91 1.11 0.73 0.50

1.93E-07 3.06E-01 9.21E-01 2.71E-01 6.05E-01 4.16E-02 2.33E-04

0.63 0.81 0.86 1.03 0.99 0.81 1.03

2.27E-02 6.17E-02 1.92E-02 8.83E-01 9.45E-01 1.33E-01 6.29E-01

26.67 2.39 1.37 1.69 1.09 3.67 9.08

1.40E-02 3.70E-01 6.73E-02 2.53E-01 3.74E-01 1.58E-02 6.25E-03

0.34 0.67 0.74

3.48E-06 4.19E-03 2.75E-03

0.98 0.81 0.85

8.21E-01 7.53E-02 7.76E-02

1.66 6.77 1.86

1.20E-01 2.29E-03 5.26E-03

1.20 1.01 1.27 1.00 1.05 0.98 1.01 0.98

5.93E-02 9.18E-01 1.50E-01 9.32E-01 3.13E-01 6.74E-01 6.96E-01 8.70E-01

0.79 0.88 0.72 0.85 0.77 1.10 0.86 0.80

1.74E-02 1.53E-01 1.02E-02 9.16E-03 1.21E-02 2.31E-01 4.33E-02 6.27E-04

2.27 4.08 1.13 1.92 1.32 2.35 2.70 1.57

5.94E-03 7.75E-02 1.78E-01 1.42E-03 2.02E-03 1.36E-02 2.53E-02 1.30E-01

1.60 0.79 1.04 1.76 0.59 1.02 1.04 0.79 0.93 0.22 0.40 0.60 0.58 0.58 0.75


0.80 0.87 0.98 0.94 0.90 0.82 1.35 0.87 1.16 0.96 0.90 1.21 0.94 0.81 0.82


1.44 2.45 1.30 0.80 0.99 0.55 0.75 2.62 0.62 25.98 3.61 3.53 0.93 1.18 1.03


2.10

9.72E-04

0.96

5.59E-01

0.80

9.42E-02


IS1096, tnpA protein IS1096, tnpA protein IS1096, tnpR protein methylated-DNA--protein-cysteine methyltransferase UDP-N-acetylglucosamine 1carboxyvinyltransferase conserved hypothetical protein ATP:cob(I)alamin adenosyltransferase ATP synthase F1, epsilon subunit ATP synthase F1, beta subunit ATP synthase F1, gamma subunit ATP synthase F1, alpha subunit ATP synthase delta chain bacteriophage lysis protein ATP synthase F0, C subunit ATP synthase F0, A subunit conserved hypothetical protein hypothetical protein glycosyl trasferase Sua5/YciO/YrdC/YwlC family protein modification methylase, HemK family protein peptide chain release factor 1 ribosomal protein L31 acyl-CoA synthase putative transcriptional regulator transcription termination factor Rho homoserine kinase threonine synthase homoserine dehydrogenase diaminopimelate decarboxylase arginyl-tRNA synthetase hypothetical protein RemO protein peptide synthetase ScpsB, putative transcriptional regulator, TetR family protein hypothetical protein CalU12 protein

murA atpC atpD atpG atpA atpE atpB

prfA rpmE rho thrB thrC lysA argS

1.16 0.99 1.02

4.33E-01 9.26E-01 8.58E-01

0.78 0.73 0.92

2.18E-02 2.27E-02 2.15E-01

1.87 1.32 1.41

5.82E-02 1.55E-01 1.39E-02

2.33

3.95E-01

1.17

1.66E-01

0.92

3.33E-01

0.96 0.36 1.23 0.49 0.40 0.37 0.71 0.63 1.02 0.56 0.52 0.59 0.63 0.36 0.61 0.70 0.56 1.72 1.19 1.33 0.57 0.31 0.29 0.34 0.24 0.34 4.50 0.98 1.01 0.84 1.73 0.62

8.40E-01 1.24E-04 3.27E-01 4.05E-03 7.20E-04 8.65E-04 2.89E-02 1.77E-03 9.24E-01 7.73E-03 5.58E-03 1.17E-02 2.61E-02 6.82E-05 3.81E-05 4.12E-02 8.16E-04 1.84E-02 4.19E-01 4.31E-02 1.83E-04 4.95E-06 7.02E-06 2.64E-05 4.53E-06 2.85E-05 1.19E-02 8.41E-01 7.97E-01 1.00E-01 4.42E-03 6.18E-04

0.89 0.88 0.93 0.93 0.92 1.16 0.83 1.01 0.90 1.09 0.96 0.89 0.95 1.30 1.21 1.37 1.18 1.07 2.19 0.88 1.43 1.37 1.65 1.85 3.55 3.69 2.84 1.08 1.09 0.96 0.94 1.02


0.87 2.78 0.91 2.85 3.04 2.52 1.58 1.55 1.90 3.05 1.77 2.40 2.50 1.36 2.00 3.07 1.49 0.85 0.97 1.10 0.88 2.28 0.90 1.43 1.93 1.31 1.57 0.96 1.47 1.44 0.57 1.33



conserved hypothetical protein two-component system sensor kinase two-component system response regulator hypothetical protein oxidoreductase acetyltransferase glyoxalase/bleomycin resistance protein/dioxygenase rrf2 family protein (putative transcriptional regulator) flavin-nucleotide-binding protein isochorismatase hydrolase 3'(2'),5'-bisphosphate nucleotidase, putative sulfate adenylytransferase, large subunit/adenylylsulfate kinase sulfate adenylyltransferase, small subunit major facilitator superfamily protein MFS_1 phosphotransferase enzyme family protein, putative conserved hypothetical protein transcriptional regulator, TetR family protein conserved hypothetical protein, putative carbonic anhydrase glycosyl transferase, family protein 39 glycosyl transferase integral membrane protein sensor histidine kinase DNA-binding response regulator hypothetical protein hypothetical protein hypothetical protein flagella membrane glycoprotein 1B, putative oligopeptide transport system permease protein AppB ABC transporter, permease protein OppC ABC transporter, ATP-binding protein OppD hydrolase, alpha/beta fold family protein

cysNC cysD

oppC oppD

0.57 3.01 2.26 3.18 1.14 1.32

4.13E-03 2.40E-03 1.31E-02 3.80E-03 7.02E-03 1.71E-02

0.92 0.54 0.62 0.61 1.06 1.17

3.95E-01 1.50E-02 7.02E-03 4.81E-02 3.84E-01 4.40E-01

2.19 2.73 2.37 1.77 1.20 1.26

5.61E-02 2.33E-01 2.23E-01 3.31E-01 1.08E-01 2.79E-02

3.61

3.30E-03

0.81

6.77E-02

0.82

1.23E-01

0.86 0.66 1.18 0.59

3.75E-02 2.40E-03 2.46E-01 4.31E-05

0.78 1.00 0.95 0.97

1.83E-02 9.61E-01 3.24E-01 3.08E-01

1.23 0.46 0.29 1.40

9.31E-02 6.71E-03 1.83E-04 5.85E-02

0.44 0.57 0.71

3.02E-03 8.86E-04 5.02E-02

0.86 0.90 0.91

7.05E-02 1.60E-01 3.38E-01

1.09 1.61 1.13

2.16E-01 8.83E-02 3.22E-01

1.22 1.45 0.87 1.38 1.46 1.26 0.98 1.05 1.10 2.26 4.52 1.56 3.98 1.00

4.81E-02 2.00E-01 1.77E-01 5.51E-02 8.80E-03 2.83E-01 7.82E-01 7.30E-01 1.61E-01 1.34E-03 2.77E-04 1.99E-03 3.65E-03 9.62E-01

1.44 1.05 1.04 1.11 1.45 1.15 1.31 1.10 1.02 0.73 0.75 0.54 1.04 1.31

2.34E-01 5.04E-01 5.59E-01 2.44E-01 2.58E-01 3.26E-01 2.56E-01 5.11E-01 7.16E-01 2.09E-03 1.54E-01 4.67E-03 7.95E-01 6.21E-01

1.09 1.01 1.05 0.90 1.88 1.05 1.28 0.96 3.32 80.88 0.50 1.70 0.24 0.91

1.23E-01 7.89E-01 2.95E-01 1.82E-01 2.19E-01 1.66E-01 5.28E-01 2.65E-01 1.03E-01 3.62E-01 1.41E-03 1.36E-01 3.90E-05 4.60E-01

0.76 0.44 0.59 1.31

1.67E-02 7.32E-04 1.30E-02 5.29E-02

0.86 0.96 1.12 1.00

1.36E-01 7.67E-01 1.24E-01 9.97E-01

2.30 3.18 1.32 1.83

3.79E-02 4.22E-02 1.67E-01 5.94E-02

MSMEG_4999 bacterial extracellular solute-binding protein, family protein 5 MSMEG_5000 transcriptional regulator, LysR family protein MSMEG_5001 pesticide degrading monooxygenase MSMEG_5002 conserved hypothetical protein MSMEG_5003 O-methyltransferase, family protein 3 MSMEG_5004 DNA repair exonuclease MSMEG_5005 LprC protein MSMEG_5006 phosphohistidine phosphatase MSMEG_5007 LprB protein MSMEG_5008 ABC transporter, ATP-binding protein MSMEG_5009 ABC transporter MSMEG_5010 conserved hypothetical protein MSMEG_5011 hypothetical protein MSMEG_5012 trans-sialidase, putative MSMEG_5013 conserved hypothetical protein MSMEG_5014 copper-translocating P-type ATPase MSMEG_5015 secreted protein MSMEG_5016 conserved domain protein MSMEG_5017 lipoprotein MSMEG_5018 Adenylate and Guanylate cyclase catalytic domain protein MSMEG_5019 regulatory protein MSMEG_5020 acetoin(diacetyl) reductase MSMEG_5021 alcohol dehydrogenase, zinc-containing MSMEG_5022 flavin-containing monooxygenase FMO MSMEG_5023 chitooligosaccharide deacetylase MSMEG_5024 T/U mismatch-specific DNA glycosylase MSMEG_5025 putative transcriptional regulator MSMEG_5026 conserved hypothetical protein MSMEG_5027 glyoxalase family protein MSMEG_5028 HIT family protein MSMEG_5029 alkanal monooxygenase alpha chain MSMEG_5030 conserved hypothetical protein TIGR00026 MSMEG_5031 uracil-DNA glycosylase superfamily protein MSMEG_5032 putative transcriptional regulator MSMEG_5033 Tap protein; this gene contains a frame shift which is not the result of sequencing error

1.03 1.29 0.99 0.84 1.34 0.72 0.83 1.09 0.98 0.80 0.72 3.61 2.49 0.97 1.10 0.86 1.14 1.44 0.85


0.87 0.92 1.59 1.01 0.88 1.04 0.81 0.83 0.96 0.90 0.98 0.66 0.90 1.13 0.87 0.79 0.97 0.77 0.90


0.81 1.14 2.26 1.97 1.59 2.74 1.20 1.23 1.02 1.22 1.03 1.94 1.36 1.00 1.17 2.15 1.40 0.89 0.84


1.00 2.24 0.88 0.94 1.08 0.82 0.81 1.19 0.94 1.66 1.81 3.40 0.95 2.06 1.25


1.22 1.32 1.66 1.77 1.45 0.86 1.38 1.55 1.06 0.86 0.88 1.01 0.87 0.82 1.37


2.19 7.25 2.26 1.32 0.43 1.05 1.19 1.51 2.07 1.34 1.19 0.71 0.86 1.07 1.37


1.49

1.22E-01

1.22

1.29E-02

0.90

1.66E-01

MSMEG_5033 Tap protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_5034 hypothetical protein MSMEG_5035 conserved hypothetical protein MSMEG_5036 rhomboid family protein MSMEG_5037 oxidoreductase, FAD-binding MSMEG_5038 putative cytochrome P450 123 MSMEG_5039 Siderophore-interacting protein MSMEG_5040 transcriptional regulator, TetR family protein MSMEG_5041 probable acyltransferase MSMEG_5042 ATP-dependent rna helicase, dead/deah box family protein MSMEG_5043 LprE protein MSMEG_5044 ATPase MSMEG_5045 D-2-hydroxyglutarate dehydrogenase MSMEG_5046 drug transporter MSMEG_5047 drug resistance transporter Bcr/CflA subfamily protein MSMEG_5048 conserved hypothetical protein MSMEG_5049 2-oxoglutarate dehydrogenase, E1 component MSMEG_5050 methionine aminopeptidase, type I MSMEG_5051 major facilitator superfamily protein MSMEG_5052 DNA-binding protein MSMEG_5053 short chain alcohol dehydrogenase MSMEG_5054 ABC transporter, quaternary amine uptake transporter (QAT) family protein, substratebinding protein MSMEG_5055 NAD-dependent malic enzyme MSMEG_5056 magnesium and cobalt transport protein CorA MSMEG_5057 conserved hypothetical protein MSMEG_5058 ABC transporter, ATP-binding protein SugC MSMEG_5059 ABC transporter, permease protein SugB MSMEG_5060 ABC transporter, permease protein SugA MSMEG_5061 Bacterial extracellular solute-binding protein MSMEG_5062 conserved hypothetical protein MSMEG_5063 integral membrane protein MSMEG_5064 malyl-CoA lyase MSMEG_5065 Mg/Co/Ni transporter MgtE

sucA map

corA

0.98 1.72 1.38 0.44 0.80 1.26 1.11 1.05 0.92

8.54E-01 7.59E-02 2.62E-01 6.38E-04 5.57E-03 6.53E-03 4.49E-01 9.04E-01 7.18E-01

0.93 0.86 1.14 3.68 1.05 0.91 1.29 1.08 1.04

6.51E-01 2.61E-01 3.20E-01 3.33E-01 3.53E-01 2.48E-01 2.95E-01 7.01E-01 6.80E-01

1.19 0.89 1.14 1.50 1.13 0.98 16.74 0.96 1.84

1.72E-01 3.22E-01 4.05E-01 3.05E-01 1.69E-02 9.44E-01 3.43E-01 5.44E-01 4.55E-02

1.07 0.95 0.79 0.84 1.15

1.47E-01 8.28E-01 1.83E-01 1.97E-02 7.75E-02

1.05 0.99 0.88 1.07 1.10

4.26E-01 8.92E-01 1.72E-01 7.74E-01 6.31E-01

2.05 1.51 1.42 1.36 1.87

7.54E-02 1.77E-01 1.46E-01 1.22E-01 2.61E-02

0.84 2.10 0.76 2.34 0.41 1.26 1.24

2.08E-01 4.40E-03 6.41E-03 5.34E-03 1.26E-03 3.76E-02 1.14E-02

1.57 1.41 1.18 0.95 6.32 0.64 0.72

1.33E-01 1.25E-01 7.17E-02 4.72E-01 2.05E-01 5.02E-03 2.70E-02

1.08 6.34 1.51 0.22 11.65 0.67 1.09

7.52E-01 2.89E-02 3.40E-04 2.67E-06 8.07E-04 1.67E-03 3.17E-01

0.55 0.67 1.60 0.69 1.37 1.90 1.41 2.06 1.06 0.71 0.55 0.74

1.01E-03 6.43E-03 9.60E-02 1.14E-02 9.26E-03 2.46E-03 4.55E-04 2.65E-05 3.49E-01 1.17E-02 4.62E-03 3.42E-03

1.95 1.19 0.93 1.90 1.24 1.03 1.13 0.84 1.86 0.88 3.30 1.22

9.40E-02 4.65E-01 6.62E-01 6.03E-02 3.45E-02 4.86E-01 1.15E-01 3.88E-02 1.16E-01 3.25E-01 9.37E-02 3.04E-01

1.07 0.48 0.97 0.67 0.48 0.42 0.74 0.39 0.52 1.69 1.39 1.66

5.18E-01 1.46E-03 2.30E-01 5.41E-02 6.98E-03 5.87E-03 4.02E-01 8.75E-04 3.00E-04 4.60E-02 3.58E-01 1.70E-02

MSMEG_5066 MSMEG_5067 MSMEG_5068 MSMEG_5069 MSMEG_5070 MSMEG_5071 MSMEG_5072 MSMEG_5073 MSMEG_5074 MSMEG_5075 MSMEG_5076 MSMEG_5077 MSMEG_5078 MSMEG_5079 MSMEG_5080 MSMEG_5081 MSMEG_5082 MSMEG_5083 MSMEG_5084 MSMEG_5085 MSMEG_5086 MSMEG_5087 MSMEG_5088 MSMEG_5089 MSMEG_5090 MSMEG_5091 MSMEG_5092 MSMEG_5095

MSMEG_5097 MSMEG_5098 MSMEG_5099 MSMEG_5100 MSMEG_5100

integral membrane protein secreted protein Mrp protein sec-independent translocase Trypsin conserved hypothetical protein extracytoplasmic function alternative sigma factor O-methyltransferase, family protein 3 probable transcriptional regulatory protein ABC transporter ATP-binding protein ABC transporter membrane-spanning protein probable conserved integral membrane protein glgC glucose-1-phosphate adenylyltransferase conserved hypothetical protein glycogen synthase conserved hypothetical protein tag DNA-3-methyladenine glycosylase I conserved hypothetical protein glycosyl transferase, group 2 family protein folP dihydropteroate synthase very-long-chain acyl-CoA synthetase conserved hypothetical protein tetratricopeptide repeat family protein conserved hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein This gene is disrupted by an IS1096 element.; ISMsm1, transposase orfB, truncation; identified by similarity to GP:16551202; match to protein family HMM PF00665 hypothetical protein hypothetical protein conserved hypothetical protein pyruvate ferredoxin/flavodoxin oxidoreductase family protein pyruvate ferredoxin/flavodoxin oxidoreductase family protein

0.70 0.89 0.86 0.90 1.10 1.91 3.20 0.89 0.98 1.18 1.12 1.27 1.13 0.79 1.01 1.44 0.68 0.69 0.47 1.05 0.56 0.77 0.90 1.05 0.84 0.80 0.80


1.34 1.21 1.12 3.19 3.16 2.12 0.59 0.82 1.09 1.29 1.09 0.90 1.32 1.05 0.88 0.69 0.94 1.05 1.23 1.05 1.12 0.82 1.14 1.51 1.26 0.80 1.10


1.01 0.34 0.92 2.58 2.86 3.27 1.74 2.41 1.21 1.50 1.39 2.15 0.38 1.41 1.26 1.21 1.48 1.18 0.74 1.42 1.95 1.58 1.00 0.65 0.67 1.16 0.85


0.78 1.87 1.31 0.64

1.19E-01 4.18E-01 3.69E-01 8.52E-03

1.07 0.81 1.25 0.93

6.82E-01 9.67E-02 1.50E-01 2.34E-01

1.13 2.42 1.30 1.18

5.40E-01 1.27E-01 4.19E-01 4.66E-01

0.64

1.18E-03

1.34

5.49E-02

0.88

1.10E-01

0.82

8.80E-02

0.96

5.74E-01

0.98

8.34E-01



MSMEG_5124 MSMEG_5125 MSMEG_5126 MSMEG_5127 MSMEG_5128 MSMEG_5129

hypothetical protein ABC transporter ATP-binding protein dapE succinyl-diaminopimelate desuccinylase tetrahydropicolinate succinylase hypothetical protein HNH endonuclease secreted protein conserved hypothetical protein conserved hypothetical protein sulfatase; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error conserved hypothetical protein hypothetical protein conserved hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error acyl-CoA synthase hypothetical protein conserved hypothetical protein proline dehydrogenase nudix hydrolase pruA 1-pyrroline-5-carboxylate dehydrogenase conserved hypothetical protein aminotransferase, classes I and II ferredoxin acyl-CoA dehydrogenase, C- domain protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF08028 2,4-dienoyl-coA reductase YceI like family protein FO synthase hypothetical protein conserved hypothetical protein N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxyalpha- D-Glucopyranoside Deacetylase MshB

1.29 1.17 0.98 0.37 1.29 1.29 3.33 2.23 5.23

8.05E-02 5.49E-01 8.47E-01 1.72E-05 1.99E-01 1.06E-01 1.72E-02 3.08E-03 7.38E-03

1.12 1.44 0.88 1.11 1.30 1.69 0.87 1.27 0.92

4.86E-01 4.98E-02 1.79E-01 5.72E-01 6.71E-02 1.44E-01 2.05E-01 4.15E-02 2.45E-01

0.85 1.09 0.90 1.10 0.78 1.44 1.29 0.80 1.00

3.83E-01 5.23E-01 1.98E-01 6.93E-01 2.43E-01 4.59E-01 1.24E-01 1.32E-01 9.64E-01

1.11 2.19 1.59

3.92E-01 1.55E-03 3.14E-03

1.24 1.01 0.99

2.02E-01 8.84E-01 8.65E-01

1.44 0.31 0.94

1.85E-01 4.50E-04 8.86E-01

0.65 0.70 1.95 2.16 4.15 1.25 8.69 1.20 0.59 0.71

1.59E-05 2.67E-03 1.32E-02 1.95E-02 2.82E-02 1.88E-02 1.38E-02 6.08E-02 3.37E-03 2.91E-03

1.13 1.06 0.78 0.86 1.36 0.83 1.61 1.03 1.18 1.13

1.83E-01 6.10E-01 5.52E-02 1.70E-01 3.11E-01 5.16E-02 1.87E-01 7.31E-01 2.13E-01 1.30E-01

1.86 1.42 0.81 1.11 3.47 0.73 3.19 1.26 3.56 2.56

1.65E-02 3.53E-02 2.62E-01 9.92E-02 2.48E-01 3.82E-03 2.64E-01 3.04E-01 4.57E-02 1.26E-04

1.09 1.40 2.04 0.65 1.07 0.54

4.29E-01 5.12E-01 6.53E-02 2.48E-03 2.34E-01 2.53E-03

1.51 0.91 4.89 1.24 1.19 0.73

1.92E-01 3.80E-01 1.13E-01 2.81E-01 3.03E-01 2.50E-02

0.81 1.42 1.13 1.40 7.32 0.92

1.03E-01 5.26E-02 3.24E-01 1.20E-02 3.99E-01 3.47E-01

0.47

2.88E-04

0.82

1.54E-01

1.69

3.79E-02

MSMEG_5130 bacterial extracellular solute-binding protein, family protein 5 MSMEG_5131 hypothetical protein MSMEG_5132 GTP-binding protein TypA/BipA MSMEG_5133 hypothetical protein MSMEG_5134 hypothetical protein MSMEG_5135 hypothetical protein MSMEG_5136 helix-turn-helix motif MSMEG_5137 respiratory nitrate reductase, gamma subunit MSMEG_5138 nitrate reductase molybdenum cofactor assembly chaperone MSMEG_5139 nitrate reductase, beta subunit MSMEG_5140 nitrate reductase, alpha subunit MSMEG_5141 nitrate/nitrite transporter protein MSMEG_5142 beta-glucosidase A MSMEG_5143 HTH-type transcriptional regulator DegA MSMEG_5144 xylosidase/arabinosidase MSMEG_5145 extracellular solute-binding protein, family protein 1 MSMEG_5146 binding protein dependent transport protein MSMEG_5147 sugar ABC-transporter integral membrane protein MSMEG_5148 CTP pyrophosphohydrolase MSMEG_5149 conserved transmembrane protein MSMEG_5150 putative pterin-4-alpha-carbinolamine MSMEG_5152 hypothetical protein MSMEG_5152 hypothetical protein MSMEG_5153 conserved hypothetical protein MSMEG_5154 conserved hypothetical protein MSMEG_5155 nitroreductase MSMEG_5156 base excision DNA repair protein, HhH-GPD family protein MSMEG_5157 hypothetical protein MSMEG_5158 sensor histidine kinase MSMEG_5159 DNA-binding response regulator, putative MSMEG_5160 putative integral membrane protein MSMEG_5161 transmembrane transport protein MSMEG_5162 cinnamoyl ester hydrolase

typA

narI narJ narH

0.60 4.17 0.52 0.83 0.86 5.06 3.24 1.82

4.22E-03 2.50E-04 3.01E-05 9.00E-02 2.90E-01 3.36E-04 1.09E-02 4.19E-03

1.15 0.97 0.85 0.80 0.81 0.89 5.81 0.94

4.13E-01 8.90E-01 4.27E-02 4.50E-03 3.61E-02 2.15E-01 1.86E-03 3.84E-01

2.65 0.61 1.78 1.05 1.05 1.38 2.98 0.74

4.37E-02 7.40E-02 1.39E-03 5.02E-01 6.25E-01 5.62E-02 2.25E-02 1.83E-01

1.39 1.48 1.87 3.99 2.30 6.87 1.36

2.27E-01 1.84E-01 8.47E-02 2.52E-01 2.00E-02 3.51E-01 1.47E-02

1.59 1.22 1.14 1.25 0.87 0.85 0.99

1.88E-01 4.88E-02 1.89E-01 2.46E-01 1.85E-01 6.55E-02 9.64E-01

0.86 0.86 0.88 0.88 0.97 0.87 3.73

1.85E-01 2.92E-01 1.66E-01 9.03E-02 7.37E-01 1.84E-01 3.69E-01

0.89 0.96 0.74 0.57 0.90 1.22 2.54 1.60 1.74 1.86 2.06

3.22E-01 8.67E-01 9.63E-02 4.13E-02 2.03E-02 1.41E-02 3.34E-02 1.21E-01 8.38E-02 1.33E-03 9.19E-03

1.03 0.81 0.95 1.19 0.94 1.05 0.50 0.62 0.68 1.24 0.86

8.24E-01 1.34E-02 5.05E-01 5.09E-01 3.80E-01 4.83E-01 3.13E-04 3.62E-03 8.62E-03 1.77E-01 1.92E-01

0.44 0.85 0.85 1.00 3.32 0.63 1.84 0.80 1.09 0.99 0.83

6.64E-03 4.47E-02 8.16E-02 8.49E-01 4.41E-02 5.08E-02 2.90E-01 5.17E-01 7.49E-01 9.51E-01 1.71E-01

1.04 1.30 0.93 0.81 0.84 1.11 1.17

6.35E-01 1.78E-01 2.67E-01 5.42E-02 2.81E-01 2.28E-01 3.80E-01

1.06 1.15 1.12 0.97 0.89 1.19 0.76

5.41E-01 2.69E-01 1.42E-01 7.70E-01 4.13E-01 2.72E-01 4.65E-02

1.47 0.72 1.07 1.13 0.99 1.39 0.99

1.31E-02 6.50E-02 2.59E-01 4.00E-01 8.47E-01 3.85E-02 3.54E-01

MSMEG_5163 ABC proline/glycine betaine family protein transporter, periplasmic ligand binding protein MSMEG_5164 zinc-binding alcohol dehydrogenase family protein MSMEG_5165 integral membrane protein MSMEG_5166 Na+/solute symporter MSMEG_5167 major facilitator superfamily protein MFS_1 MSMEG_5168 conserved hypothetical protein MSMEG_5169 conserved hypothetical protein MSMEG_5170 pyridoxamine 5'-phosphate oxidase family MSMEG_5171 conserved hypothetical protein MSMEG_5172 conserved hypothetical protein MSMEG_5173 O-methyltransferase, putative MSMEG_5174 regulatory protein GntR, HTH MSMEG_5175 NAD-dependent deacetylase MSMEG_5176 methyltransferase type 11 MSMEG_5177 regulatory protein, TetR MSMEG_5178 integral membrane protein MSMEG_5179 DoxX subfamily protein, putative MSMEG_5180 conserved hypothetical protein MSMEG_5182 2-Nitropropane dioxygenase MSMEG_5183 3-Hydroxyacyl-CoA dehydrogenase MSMEG_5184 alpha-methylacyl-CoA racemase, putative MSMEG_5185 enoyl-CoA hydratase PaaB MSMEG_5186 HicB family protein MSMEG_5187 tetracycline-resistance determinant TetV MSMEG_5188 caax amino protease family protein MSMEG_5189 oxidoreductase MSMEG_5190 TetR-family protein transcriptional regulator MSMEG_5191 siderophore binding protein MSMEG_5192 aldo/keto reductase MSMEG_5193 transcriptional regulator, AraC family protein MSMEG_5194 integral membrane protein MSMEG_5195 hypothetical protein MSMEG_5196 fasciclin domain protein MSMEG_5197 long-chain specific acyl-CoA dehydrogenase MSMEG_5198 carnitinyl-CoA dehydratase MSMEG_5199 putative acyl-CoA dehydrogenase

1.08

2.60E-02

1.83

4.17E-02

0.99

8.77E-01

4.20 4.98 4.65 2.60 1.07 1.88 2.37 0.97 1.75 1.33 3.51 1.35 2.18 1.35 1.39 2.20 1.82 1.03 1.22 1.40 1.81 1.38 1.19 1.21 1.28 1.31 0.43 0.89 0.66 0.89 0.79 0.44 1.67 1.69 1.87

2.78E-05 4.16E-03 1.77E-03 9.87E-04 4.58E-01 2.37E-03 8.59E-05 5.14E-01 8.26E-04 3.68E-02 5.71E-04 4.78E-02 5.53E-03 4.47E-02 1.13E-01 4.17E-02 1.90E-01 7.91E-01 9.47E-02 5.67E-02 8.44E-03 1.15E-01 2.40E-01 1.76E-01 2.76E-01 7.17E-02 1.97E-05 4.98E-01 5.68E-04 2.33E-01 9.50E-02 5.10E-05 1.53E-03 2.08E-03 2.76E-03

0.64 0.75 0.92 0.92 0.99 0.78 0.72 0.81 0.90 0.75 0.92 0.68 0.82 0.98 0.93 1.29 1.28 1.02 0.78 0.88 0.81 0.78 1.13 1.07 1.02 0.92 0.91 1.06 0.91 0.98 0.93 0.99 1.02 0.95 0.98


1.04 0.49 0.38 0.92 1.11 0.81 0.52 0.99 0.79 0.94 1.35 1.19 0.62 0.94 1.04 1.24 0.63 1.59 1.37 1.80 1.06 1.84 1.11 1.34 1.38 1.04 1.65 1.03 1.03 1.27 0.97 0.61 0.97 1.01 1.18



hypothetical protein regulatory protein GntR, HTH conserved membrane protein DoxX subfamily protein, putative oxidoreductase, short chain dehydrogenase/reductase family protein conserved hypothetical protein regulatory protein conserved hypothetical protein conserved hypothetical protein hydrolase, alpha/beta fold family protein hydrolase aminotransferase class-III conserved hypothetical protein conserved hypothetical protein RNA polymerase sigma-70 factor conserved hypothetical protein glyoxalase family protein hypothetical protein conserved hypothetical protein riboflavin biosynthesis protein RibD C- domain protein esterase/lipase/thioesterase GCN5-related N-acetyltransferase GTP-binding protein YchF conserved hypothetical protein 4-hydroxy-3-methylbut-2-enyl diphosphate reductase conserved hypothetical protein exodeoxyribonuclease VII, large subunit exodeoxyribonuclease VII, small subunit 3-beta hydroxysteroid dehydrogenase/isomerase family protein 3-beta hydroxysteroid dehydrogenase/isomerase family protein hypothetical protein conserved hypothetical protein hypothetical protein

ychF ispH xseA xseB

0.95 1.00 1.17 1.13

4.72E-01 9.94E-01 5.49E-01 5.30E-02

1.01 0.79 0.97 0.94

8.50E-01 1.16E-02 8.24E-01 6.53E-01

1.00 1.38 0.76 0.97

9.20E-01 1.53E-01 1.34E-01 7.68E-01

1.77 0.69 1.21 0.52 0.67 0.50 0.90 0.42 1.64 0.78 0.81 1.17 2.28 3.30 2.35


1.11 1.26 1.25 0.98 1.11 1.13 1.02 0.91 1.21 1.17 0.92 0.85 0.79 0.93 1.00


0.98 0.98 1.46 0.88 0.97 3.87 0.94 2.26 0.96 1.03 1.13 1.20 1.52 2.00 0.87


1.16 0.80 0.46 0.46 0.59

6.99E-02 4.94E-03 4.09E-04 2.37E-04 3.03E-03

1.02 0.86 0.95 0.93 1.06

8.62E-01 4.23E-03 5.40E-01 1.25E-01 3.33E-01

1.34 0.97 1.27 1.80 1.17

9.08E-02 7.37E-01 1.27E-01 1.16E-01 2.88E-01

1.50 0.82 0.44 0.50

4.24E-03 4.02E-02 4.70E-05 7.14E-06

0.84 0.92 0.97 1.00

6.50E-02 2.63E-01 6.08E-01 9.77E-01

1.25 0.81 1.40 1.07

1.67E-01 3.14E-01 2.91E-02 5.92E-01

0.26

1.42E-05

1.52

4.24E-02

1.13

4.45E-01

0.39 3.41 8.48 9.50

6.85E-05 4.43E-02 1.24E-03 1.93E-03

1.18 0.66 0.76 0.63

1.94E-01 1.93E-02 2.07E-01 5.19E-02

0.99 1.97 0.93 0.41

9.59E-01 3.28E-02 6.27E-01 9.67E-03

MSMEG_5232 hypothetical protein MSMEG_5233 RmlD substrate binding domain superfamily protein MSMEG_5234 short-chain dehydrogenase/reductase SDR MSMEG_5235 short chain dehydrogenase family protein MSMEG_5236 dienelactone hydrolase family protein MSMEG_5237 conserved hypothetical protein MSMEG_5238 conserved hypothetical protein MSMEG_5239 fructose-1,6-bisphosphatase, class II MSMEG_5240 fumarate hydratase class II MSMEG_5241 GAF family protein MSMEG_5242 acyltransferase, ws/dgat/mgat subfamily protein MSMEG_5243 helix-turn-helix motif MSMEG_5244 two component transcriptional regulatory protein devr MSMEG_5245 universal stress protein family protein MSMEG_5246 conserved hypothetical protein MSMEG_5247 PhoH family protein MSMEG_5248 acyl-[ACP] desaturase MSMEG_5249 serine hydroxymethyltransferase MSMEG_5250 CalR9 protein MSMEG_5251 hypothetical protein MSMEG_5252 pantothenate kinase MSMEG_5253 conserved hypothetical protein MSMEG_5254 conserved hypothetical protein MSMEG_5255 conserved hypothetical protein MSMEG_5256 undecaprenyl diphosphate synthase MSMEG_5257 channel protein, hemolysin III family protein MSMEG_5258 steroid delta-isomerase MSMEG_5259 conserved hypothetical protein MSMEG_5260 conserved hypothetical protein MSMEG_5261 mycothiol conjugate amidase Mca MSMEG_5262 conserved hypothetical protein MSMEG_5263 transcription elongation factor GreA MSMEG_5264 conserved hypothetical protein MSMEG_5264 conserved hypothetical protein MSMEG_5265 putative cystathionine gamma-synthase MSMEG_5266 RDD family protein

glpX

glyA coaA

uppS

1.09

4.21E-01

1.42

7.31E-02

1.29

5.35E-01

0.72 0.84 1.00 1.00 1.27 0.98 0.97 0.92 1.49 1.41 1.06

1.57E-01 4.07E-01 9.82E-01 9.69E-01 1.82E-01 6.02E-01 6.86E-01 2.10E-01 1.42E-02 1.52E-01 7.06E-01

1.12 1.58 1.05 0.82 1.26 0.89 0.97 0.74 3.21 17.47 19.21

2.52E-01 4.48E-02 5.24E-01 1.23E-02 2.65E-01 8.58E-02 4.79E-01 1.96E-02 4.04E-03 2.73E-02 1.83E-02

0.70 0.48 1.21 1.64 1.17 1.30 0.70 0.56 4.10 24.46 12.08

8.46E-02 5.04E-03 6.67E-01 2.46E-02 5.87E-01 2.73E-01 1.57E-02 8.25E-03 2.27E-03 1.23E-02 1.59E-03

1.95 1.92 1.39 1.05 0.31 0.58 0.81 1.88 0.51 2.43 1.30 2.56 1.19 1.36 0.77 0.82 0.53 0.46 0.60 1.34 0.43 0.36 0.40 1.23


3.33 8.81 10.25 1.04 1.38 1.05 1.08 1.29 0.94 1.45 1.30 0.90 1.18 0.79 1.04 1.09 1.19 1.33 0.83 0.64 0.79 1.00 0.89 1.03


7.78 13.20 17.70 2.19 19.56 1.40 1.08 1.10 1.83 1.47 1.15 1.72 2.29 2.24 0.96 1.22 1.61 1.31 1.32 0.61 1.28 1.02 1.45 0.59



glutaryl-CoA dehydrogenase conserved hypothetical protein hypothetical protein cystathionine beta-synthase esterase conserved exported protein beta-ketoadipyl CoA thiolase phosphoribosylglycinamide formyltransferase 2 permease of the major facilitator superfamily protein enoyl-CoA hydratase probable enoyl-CoA hydratase conserved membrane-spanning protein conserved hypothetical protein cysteine dioxygenase type I superfamily protein LpqV protein transcriptional regulator hydrolase, CocE/NonD family protein patatin phospholipase, patatin family protein dihydrodipicolinate reductase, N-terminus domain protein dehydrogenase putative serine/threonine protein kinase hypothetical protein hypothetical protein acyl-CoA synthase hypothetical protein hypothetical protein hypothetical protein peroxisomal-coenzyme A synthetase hypothetical protein oxalyl-CoA decarboxylase hypothetical protein hypothetical protein short-chain type dehydrogenase/reductase transcriptional regulator aerobic C4-dicarboxylate transport protein

purT

dapB

2.29 0.73 1.10 1.01 6.23 2.51 0.48 0.52

8.99E-03 5.26E-03 3.03E-01 9.28E-01 1.01E-03 2.76E-03 1.67E-04 2.73E-04

0.88 1.17 0.90 1.79 1.15 0.74 0.78 0.93

1.41E-01 2.58E-01 2.63E-01 1.61E-01 2.55E-01 9.39E-03 4.95E-02 5.96E-01

1.19 0.66 1.04 1.69 0.26 1.74 1.67 1.13

2.28E-01 2.69E-02 7.25E-01 5.89E-02 2.17E-04 2.50E-02 4.87E-02 4.66E-01

1.88 0.38 0.74 1.00 1.66 0.75 0.88 1.55 0.82 1.11 0.73

5.85E-03 7.97E-04 6.09E-02 9.83E-01 4.87E-01 7.31E-02 8.51E-02 3.40E-02 5.63E-02 2.56E-01 2.01E-03

1.17 1.18 1.25 1.02 1.42 1.71 0.91 1.16 1.33 1.08 1.11

9.21E-03 1.31E-01 2.25E-01 4.84E-01 3.52E-02 1.05E-01 8.15E-02 2.84E-01 4.10E-01 2.92E-01 2.86E-01

0.71 1.37 1.59 1.02 2.42 5.43 0.73 1.15 1.11 1.11 1.63

1.30E-04 1.65E-01 5.46E-02 3.20E-01 8.30E-02 9.51E-03 3.51E-03 5.15E-01 5.12E-01 3.13E-01 3.97E-02

1.24 1.36 1.18 0.96 1.63 0.94 1.29 1.15 0.78 1.37 1.07 1.21 7.00 2.84 1.78 1.05 11.50


1.12 0.80 2.53 0.90 0.99 1.66 1.41 1.38 2.38 6.75 2.45 2.04 1.26 1.20 6.40 1.27 1.03


0.98 1.37 1.01 1.16 1.27 0.49 1.02 1.13 1.11 1.01 1.46 2.24 2.86 1.03 1.13 1.06 0.13



putP sodium/proline symporter two-component sensor kinase choline dehydrogenase two-component system response regulator TetR-family protein transcriptional regulator conserved hypothetical protein conserved hypothetical protein SAM-dependent methyltransferase conserved hypothetical protein ABC-type multidrug transport system ATPase component hypothetical protein conserved hypothetical protein gp35 protein glutamine ABC transporter, ATP-binding protein conserved hypothetical protein glutamine ABC transporter, permease/substratebinding protein alkylhydroperoxidase AhpD core hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved hypothetical protein SIS domain protein UDP-glucoronosyl and UDP-glucosyl transferase family; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00201; match to protein family HMM PF04101

1.88 1.97 1.10 1.53 1.36 1.77 1.13 2.30 0.92

5.68E-03 1.13E-02 4.27E-01 6.01E-02 5.61E-02 1.17E-02 5.00E-01 7.63E-03 5.28E-01

1.23 1.21 1.03 1.00 0.96 0.67 1.16 0.89 1.46

1.21E-01 1.03E-01 7.69E-01 9.27E-01 7.08E-01 6.54E-03 1.71E-01 1.31E-01 1.24E-01

0.21 0.89 1.34 1.04 1.08 9.30 2.88 1.35 1.02

4.09E-05 2.10E-01 4.57E-01 4.33E-01 6.09E-01 3.39E-02 2.28E-01 1.73E-02 9.17E-01

0.56 1.13 1.01 2.87 1.19 1.25

3.33E-04 3.23E-01 9.61E-01 1.62E-02 3.07E-01 1.21E-01

1.20 1.36 1.36 0.68 1.01 0.94

2.85E-01 4.88E-02 1.01E-01 1.46E-02 8.89E-01 1.21E-01

1.23 1.44 1.10 1.41 1.20 0.84

3.11E-01 4.99E-01 4.71E-01 6.71E-02 1.82E-01 5.37E-01

1.10 2.70 0.94 1.14 2.14 5.19 1.08 0.57 1.11 25.37 1.95 0.75 0.70

6.07E-01 2.50E-02 9.77E-02 4.72E-01 5.70E-02 3.82E-02 6.12E-01 1.57E-04 4.49E-01 6.18E-02 8.36E-04 4.77E-02 1.16E-02

1.03 1.19 0.96 1.42 0.88 2.95 1.08 0.85 1.11 0.27 0.97 1.30 1.17

8.71E-01 3.19E-01 5.57E-01 1.63E-01 4.16E-01 1.26E-01 5.05E-01 8.54E-02 4.20E-01 6.21E-03 7.88E-01 8.30E-03 2.64E-01

0.69 1.07 0.93 1.13 1.02 0.31 0.92 1.06 1.37 0.87 1.15 1.14 0.90

1.05E-01 2.48E-01 2.49E-02 4.16E-01 3.59E-01 3.99E-03 3.57E-01 5.70E-01 2.28E-01 5.86E-01 7.62E-01 4.17E-01 1.49E-01

0.51

1.89E-02

1.13

6.25E-02

0.71

6.22E-02

MSMEG_5331 UDP-glucoronosyl and UDP-glucosyl transferase family; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00201; match to protein family HMM PF04101 MSMEG_5332 transcriptional regulator, TetR family protein MSMEG_5333 hypothetical protein MSMEG_5334 conserved hypothetical protein MSMEG_5335 formamidase MSMEG_5336 amidate substrates transporter protein MSMEG_5337 putative regulatory protein, FmdB family; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM TIGR02605 MSMEG_5338 regulatory protein, MarR MSMEG_5339 nitrile hydratase regulator1 MSMEG_5340 TetR-family protein transcriptional regulator MSMEG_5341 dipeptidyl aminopeptidase/acylaminoacyl peptidase MSMEG_5342 conserved hypothetical protein MSMEG_5343 conserved hypothetical protein MSMEG_5344 hypothetical protein MSMEG_5345 glycosyl hydrolases family protein 16 MSMEG_5346 TetR-family protein transcriptional regulator MSMEG_5347 transporter, major facilitator family protein MSMEG_5348 medium-chain fatty acid-CoA ligase MSMEG_5349 conserved hypothetical protein, putative MSMEG_5350 PPE family protein, putative MSMEG_5351 hypothetical protein MSMEG_5352 conserved hypothetical protein MSMEG_5353 putative methyltransferase MSMEG_5354 O-methyltransferase, family protein 2 MSMEG_5355 hypothetical protein MSMEG_5356 hypothetical protein MSMEG_5357 conserved hypothetical protein MSMEG_5358 acetamidase/Formamidase family protein cynS MSMEG_5359 cyanate hydratase MSMEG_5360 formate/nitrate transporter

0.65 0.70 1.17 1.55 1.04 1.22

3.52E-02 1.57E-01 4.56E-01 9.18E-02 7.49E-01 3.05E-01

1.03 0.95 0.98 0.95 1.18 1.43

4.91E-01 5.37E-01 5.09E-01 7.39E-01 9.97E-02 1.95E-01

0.93 1.36 0.74 1.22 0.81 0.93

2.14E-01 3.62E-01 6.16E-02 4.02E-01 1.38E-01 2.48E-01

1.03 1.38 10.07 0.89

7.97E-01 1.85E-05 1.17E-03 2.33E-02

1.25 0.83 0.92 1.23

1.82E-01 2.20E-02 4.00E-01 1.50E-02

1.04 0.97 0.92 1.49

4.58E-01 7.23E-01 6.38E-01 1.89E-01

1.43 1.68 1.25 4.70 0.78 1.36 1.44 1.32 0.78 1.10 1.35 2.95 1.00 0.69 1.80 0.98 1.23 0.29 1.30 0.79


1.17 1.65 1.53 0.75 0.90 1.69 1.19 1.06 1.10 1.24 1.12 0.95 1.30 1.00 0.70 0.98 1.39 1.74 0.92 1.90


0.90 0.76 2.87 19.60 1.01 0.87 1.62 1.00 0.88 1.01 0.99 1.51 1.23 0.95 5.95 1.22 1.03 0.57 0.36 1.08



hypothetical protein hypothetical protein hypothetical protein amidohydrolase 2 RNA polymerase sigma-70 factor conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error ectoine/hydroxyectoine ABC transporter solutebinding protein ectoine/hydroxyectoine ABC transporter, permease protein EhuC ectoine/hydroxyectoine ABC transporter, permease protein EhuD ectoine/hydroxyectoine ABC transporter, ATPbinding protein sensor protein KdpD nitrilase 2 glutamate--ammonia ligase GntR-family protein transcriptional regulator conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative dehydrogenase/reductase SDR family protein member 4 hypothetical protein metallo-beta-lactamase family protein rhodanese-like domain protein conserved hypothetical protein conserved hypothetical protein LysA protein conserved hypothetical protein hypothetical protein K+-transporting ATPase, A subunit

1.48 0.98 0.75 1.30 1.18 0.98

2.65E-01 9.24E-01 1.68E-01 5.22E-02 5.34E-01 8.75E-01

1.47 1.24 0.89 1.37 1.44 1.07

1.56E-01 3.35E-01 4.28E-01 4.17E-01 9.91E-02 3.82E-01

0.98 1.85 1.90 1.85 1.00 1.17

6.43E-01 2.24E-01 2.13E-01 3.41E-01 9.84E-01 4.69E-01

1.24

8.82E-02

0.99

9.14E-01

0.88

1.92E-01

ehuB

2.44

7.67E-04

0.54

3.04E-02

0.46

1.77E-02

ehuC

1.28

8.22E-02

0.73

4.27E-02

0.98

9.55E-01

ehuD

1.02

8.74E-01

0.73

4.44E-02

0.78

3.27E-01

ehuA

1.24 1.89 0.78 0.65 1.33 0.89 2.78 0.94

9.66E-02 6.80E-03 5.83E-02 8.16E-02 2.57E-02 8.83E-02 5.94E-02 3.85E-01

0.71 1.07 1.03 1.01 0.86 1.18 0.56 1.71

9.38E-02 2.69E-01 9.00E-01 9.22E-01 1.65E-02 4.84E-01 6.24E-02 9.60E-02

0.71 0.94 0.99 1.05 1.35 1.99 0.64 0.92

1.80E-01 8.72E-01 7.75E-01 6.18E-01 2.63E-01 3.77E-01 1.07E-01 3.29E-01

1.56

2.35E-03

1.32

1.33E-01

1.12

3.52E-01

1.06 1.13 1.13 1.08 1.17 1.52 1.46 1.81 1.25 1.41

7.07E-01 3.98E-01 4.73E-01 2.35E-01 2.18E-01 1.16E-02 9.91E-02 2.32E-03 1.58E-01 1.36E-02

1.95 1.66 3.15 1.75 1.13 1.29 0.88 1.63 2.05 3.20

5.50E-02 1.96E-01 8.65E-02 3.64E-01 1.65E-01 1.08E-01 7.25E-02 1.09E-01 1.93E-01 1.13E-01

1.31 1.31 1.02 1.15 1.21 0.95 1.06 0.64 1.16 0.98

3.23E-01 1.93E-01 3.33E-01 4.25E-01 3.83E-01 2.69E-01 3.15E-01 1.82E-04 5.18E-01 6.10E-01

kdpA


K+-transporting ATPase, B subunit potassium-transporting ATPase C chain sensor protein KdpD KDP operon transcriptional regulatory protein KdpE ATP-dependent DNA helicase RecQ ATP-dependent DNA helicase RecQ dehydrogenase conserved hypothetical protein dehydrogenase DhgA cadmium-translocating P-type ATPase propionate--CoA ligase transcriptional regulator, ArsR family protein hypothetical protein integral membrane protein prolipoprotein diacylglyceryl transferase conserved hypothetical protein radical SAM domain protein conserved hypothetical protein immunogenic protein MPT63 exopolyphosphatase septum formation initiator subfamily protein, putative enolase LpqU protein hypothetical protein iron permease FTR1 lipoprotein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF04302 Tat-translocated enzyme hypothetical protein transcriptional regulator, MazG family protein transcription-repair coupling factor transcriptional regulator, TetR family protein UDP-N-acetylglucosamine pyrophosphorylase ribose-phosphate pyrophosphokinase arsenate reductase

kdpB

recQ

cadA

lgt

eno

mfd glmU arsC

1.26 0.96 1.87

2.84E-01 1.29E-01 7.88E-03

1.35 1.13 1.10

6.10E-02 4.56E-01 5.95E-01

1.28 1.14 1.89

3.74E-01 4.91E-01 6.92E-02

1.21 2.09 0.85 1.19 2.51 1.69 1.35 1.49 1.14 2.85 2.30 1.31 1.99 1.13 0.74 1.59 0.45


0.98 4.31 1.00 1.24 3.03 1.38 1.19 0.87 0.92 0.85 0.69 1.39 0.78 0.90 1.22 0.55 1.03


1.09 1.13 1.37 1.00 0.83 0.70 1.00 0.32 0.82 0.92 1.06 1.52 0.85 2.12 1.22 0.30 1.00


0.42 0.35 0.88 0.82 0.31

3.19E-05 4.99E-06 2.69E-01 8.89E-02 9.15E-05

1.05 0.76 1.05 1.27 0.96

5.28E-01 1.93E-02 4.64E-01 4.34E-01 6.96E-01

1.41 0.66 1.82 0.98 0.65

1.98E-01 3.63E-03 5.34E-03 7.40E-01 1.78E-02

0.29 0.58 1.01 0.47 0.46 0.86 0.48 0.58 0.41

5.88E-05 1.29E-03 9.71E-01 7.11E-04 7.71E-05 3.62E-02 5.97E-04 3.14E-04 3.36E-06

1.06 1.09 0.94 0.89 1.02 0.91 0.99 0.94 0.88

6.23E-01 5.29E-01 5.51E-01 4.20E-01 8.78E-01 4.87E-02 9.00E-01 2.81E-01 7.23E-02

0.46 0.60 1.36 3.07 2.78 1.46 1.03 2.00 2.25

1.43E-03 1.36E-02 1.39E-01 6.34E-03 3.29E-02 1.42E-01 7.73E-01 1.88E-02 9.14E-03


LpqT protein LpqT protein retinol dehydrogenase 13 ribosomal protein L25, Ctc-form peptidyl-tRNA hydrolase 4Fe-4S binding domain protein hypothetical protein acyl-CoA synthase 4-diphosphocytidyl-2C-methyl-D-erythritol kinase probable serine/threonine-protein kinase PknB dimethyladenosine transferase resuscitation-promoting factor RpfB deoxyribonuclease methionyl-tRNA synthetase glutamate dehydrogenase dehydrogenase RNA polymerase sigma-70 factor, TIGR02957 family protein conserved hypothetical protein para-aminobenzoate synthase, component I dolichyl-phosphate-mannose-protein mannosyltransferase arginine deiminase conserved hypothetical protein redox-sensitive transcriptional activator SoxR alkylated DNA repair protein conserved hypothetical protein conserved hypothetical protein choloylglycine hydrolase, putative pe family protein MK35 lipoprotein shikimate 5-dehydrogenase cyclic nucleotide-binding protein hypothetical protein conserved hypothetical protein hypothetical protein RarD protein

pth

ispE ksgA metG

pabB arcA soxR

rarD

0.34 0.81 0.76 0.60 0.46 0.96 1.44 1.23

3.66E-05 2.64E-02 2.37E-03 6.63E-04 6.64E-05 6.72E-01 1.57E-02 2.54E-02

0.66 1.14 1.00 0.85 0.85 1.14 0.88 0.71

1.46E-02 3.13E-01 9.74E-01 7.69E-03 6.17E-02 1.79E-01 5.03E-01 6.34E-02

3.25 0.75 0.76 0.68 0.92 1.00 1.82 2.58

5.17E-04 2.90E-01 1.02E-01 1.90E-02 4.71E-01 9.44E-01 8.00E-02 9.11E-03

0.37 0.93 2.05 0.46 0.50 0.40 0.55 4.69

9.13E-05 5.54E-01 1.88E-03 4.87E-04 1.32E-03 1.07E-06 7.18E-04 2.24E-03

0.97 0.98 1.04 1.15 1.33 0.83 0.75 1.22

7.95E-01 7.86E-01 4.77E-01 3.02E-01 3.80E-01 3.07E-02 1.57E-02 2.31E-01

1.43 1.04 0.27 0.70 1.05 1.40 1.35 0.41

3.10E-01 6.52E-01 3.32E-05 1.30E-01 1.18E-01 1.10E-01 1.45E-01 3.82E-03

3.64 0.98 2.00

6.54E-03 8.92E-01 1.65E-02

0.67 1.14 0.80

1.25E-02 4.07E-01 2.67E-01

0.92 1.50 1.59

8.81E-01 2.33E-01 2.68E-01

0.86 1.26 1.16 1.11 1.17 0.67 1.00 0.49 1.73 1.24 2.42 2.01 1.05 1.94 2.14 0.91


1.02 1.02 0.94 0.93 0.81 0.92 1.01 1.71 1.34 1.08 0.81 1.11 1.16 0.82 0.82 1.00


1.17 1.59 1.20 1.20 1.31 0.99 1.14 1.33 0.98 0.86 1.91 2.18 1.53 0.96 0.83 1.65


MSMEG_5463 6-phosphogluconate dehydrogenase, NADbinding MSMEG_5464 integral membrane transport protein MSMEG_5465 transcriptional regulator, AraC family protein MSMEG_5466 oxidoreductase MSMEG_5468 conserved hypothetical protein MSMEG_5469 acetyltransferase, GNAT family protein MSMEG_5470 molybdopterin biosynthesis protein MoeA 1 MSMEG_5471 UTP-glucose-1-phosphate uridylyltransferase MSMEG_5472 5,10-methenyltetrahydrofolate synthetase MSMEG_5473 transporter MSMEG_5474 universal stress protein family protein MSMEG_5475 acetate operon repressor MSMEG_5476 glyoxylate carboligase MSMEG_5477 2-hydroxy-3-oxopropionate reductase MSMEG_5478 hydroxypyruvate isomerase, putative MSMEG_5479 type I antifreeze protein MSMEG_5480 hypothetical protein MSMEG_5481 conserved hypothetical protein MSMEG_5482 large conductance mechanosensitive channel protein MSMEG_5483 porin MSMEG_5484 conserved hypothetical protein MSMEG_5485 molybdopterin biosynthesis protein MSMEG_5486 peptidase S1 and S6, chymotrypsin/Hap MSMEG_5487 sensor histidine kinase MSMEG_5488 DNA-binding response regulator MSMEG_5489 ribosomal protein L32 MSMEG_5490 conserved hypothetical protein MSMEG_5491 putative acyl-CoA dehydrogenase MSMEG_5492 acetyl-CoA carboxylase carboxyltransferase MSMEG_5493 acetyl-/propionyl-coenzyme A carboxylase alpha chain MSMEG_5494 acyl-CoA dehydrogenase fadE12 MSMEG_5495 enoyl-CoA hydratase MSMEG_5496 MscS Mechanosensitive ion channel MSMEG_5497 conserved hypothetical protein MSMEG_5498 conserved hypothetical protein

galU

gcl

mscL

rpmF

2.37 1.53 1.82 1.53 1.54 0.47 0.71 0.88 1.50 1.60 1.29 1.11 2.15 3.23 3.36 0.89 1.25 0.68


0.96 0.94 0.78 1.69 0.96 1.07 0.85 1.05 0.90 1.03 1.28 0.86 0.67 0.67 0.52 0.80 0.85 0.82


1.10 1.35 1.02 1.17 1.03 1.37 15.51 0.73 1.13 0.89 0.87 0.55 0.44 0.16 0.34 1.19 0.64 1.31


0.94 2.04 1.00 1.28 1.98 1.20 1.47 0.83 3.19 2.92 2.76

3.73E-01 1.26E-03 9.82E-01 2.73E-03 6.45E-03 1.17E-01 1.01E-02 1.85E-02 1.92E-03 5.11E-03 3.25E-03

1.99 1.33 0.87 0.60 0.78 0.65 0.79 0.75 0.78 1.15 0.84

3.09E-01 1.95E-01 1.50E-01 3.23E-03 8.93E-02 1.53E-03 2.59E-02 9.35E-02 3.86E-02 7.34E-01 1.61E-01

0.52 0.18 2.06 3.57 15.01 3.96 3.73 0.97 1.17 0.98 0.80

1.14E-02 7.58E-05 1.31E-02 4.81E-03 8.68E-03 1.04E-03 1.35E-04 3.97E-01 3.45E-01 9.37E-01 1.90E-01

2.13 2.23 1.59 1.44 1.02 1.40

5.07E-03 9.27E-03 5.68E-02 1.00E-01 8.72E-01 5.54E-02

0.73 0.89 0.86 0.94 1.22 1.32

1.13E-02 2.90E-01 5.44E-02 3.43E-01 1.54E-01 2.30E-01

0.90 0.83 1.08 1.06 0.99 0.97

4.44E-01 1.12E-01 4.75E-01 4.10E-01 2.86E-01 1.17E-01


conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein conserved secreted protein conserved hypothetical protein hypothetical protein hypothetical protein alkaline phosphatase conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error von Willebrand factor, type A magnesium chelatase serine/threonine-protein kinase PknE hypothetical protein bifunctional purine biosynthesis protein PurH phosphoribosylglycinamide formyltransferase conserved hypothetical protein antigen 34 kDa monooxygenase conserved hypothetical protein acetyl-CoA acetyltransferase transcriptional Regulator, TetR family protein peptidase succinyl-CoA synthetase, alpha subunit succinyl-CoA synthetase, beta subunit peptidoglycan-binding LysM conserved hypothetical protein hypothetical protein hypothetical protein putative aliphatic sulfonates transport permease protein SsuC ABC transporter ATP-binding protein FAD dependent oxidoreductase 4Fe-4S ferredoxin, iron-sulfur binding

purH purN

sucD sucC

2.02 1.05 2.46 0.58 0.75 1.92 1.62 4.98 0.96 1.58 0.98

2.60E-01 5.52E-01 2.69E-01 2.26E-02 7.37E-02 3.83E-03 4.80E-03 3.78E-02 8.31E-01 2.88E-01 8.58E-01

0.91 1.35 0.87 1.06 0.97 1.02 0.74 0.92 1.11 1.17 1.11

5.20E-01 2.14E-01 3.97E-01 6.05E-01 4.72E-01 8.50E-01 2.33E-02 6.59E-01 3.01E-01 1.38E-01 2.02E-02

0.92 1.86 0.97 1.04 1.56 1.25 6.92 0.86 1.03 1.08 0.70

2.98E-01 2.51E-01 4.22E-01 5.85E-01 3.96E-01 9.76E-04 1.56E-03 2.64E-01 3.18E-01 1.81E-01 1.34E-01

1.06 1.30 1.39 0.65 0.45 0.42 0.51 0.58 1.56 1.39 1.10 1.07 2.72 0.80 0.52 0.50 1.45 0.81 1.07 0.98


1.25 0.99 1.02 0.95 1.24 0.95 0.88 0.73 0.59 3.12 1.09 1.07 0.71 1.12 0.91 0.91 1.21 0.83 1.26 7.31


1.07 1.69 0.89 0.87 1.29 1.14 1.66 2.37 1.28 0.93 0.37 1.16 0.80 1.05 0.68 1.02 0.47 0.84 1.19 1.03


1.04 1.00 1.16 0.97

4.62E-01 9.89E-01 7.89E-02 6.10E-01

2.20 1.85 3.01 5.15

8.61E-02 2.83E-01 2.03E-01 1.63E-01

1.00 0.83 1.49 1.06

9.97E-01 3.75E-01 3.48E-01 2.93E-01


MSMEG_5550


ATP-dependent DNA helicase PcrA hypothetical protein chorismate mutase conserved integral membrane protein [NADP+] succinate-semialdehyde dehydrogenase hypothetical protein conserved hypothetical protein glucose-6-phosphate isomerase transcriptional regulator, HTH_3 family protein hypothetical protein oxidoreductase, short chain dehydrogenase/reductase family protein formamidopyrimidine-DNA glycosylase membrane spanning protein conserved hypothetical protein precorrin-6A synthase (deacetylating) conserved hypothetical protein protein-glutamate methylesterase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01339 protein-glutamate methylesterase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01339 stas domain protein conserved hypothetical protein CheR methyltransferase, SAM binding domain protein antar domain protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MFS permease conserved hypothetical protein hypothetical protein metabolite/sugar transport protein hypothetical protein

pcrA

pgi

cobF

cheR

0.61 2.96 0.74 0.82 1.33 3.84 0.49 0.50 0.65 2.30

8.27E-05 1.23E-02 6.21E-03 2.17E-01 7.87E-03 8.14E-03 1.84E-03 4.94E-04 6.31E-02 2.18E-01

0.93 0.60 0.72 0.79 0.78 0.82 1.03 1.03 2.05 2.63

3.36E-01 9.81E-03 4.80E-02 6.87E-02 1.46E-02 7.96E-02 7.47E-01 7.88E-01 1.21E-02 1.00E-02

1.63 1.11 1.40 1.35 0.84 0.68 1.29 0.58 0.32 0.30

1.71E-02 2.18E-01 3.89E-02 2.47E-01 1.81E-03 7.02E-03 7.84E-01 3.14E-03 1.14E-04 3.04E-04

0.67 2.09 0.70 1.19 0.42 17.35

2.53E-04 2.84E-03 7.36E-03 1.19E-01 4.94E-04 8.33E-04

1.15 0.82 1.03 1.05 1.03 0.56

3.67E-01 1.00E-01 6.53E-01 5.17E-01 8.78E-01 2.92E-02

1.15 1.01 1.18 0.92 0.98 3.00

3.64E-01 9.18E-01 3.71E-01 4.44E-01 5.40E-01 3.16E-02

2.50

9.17E-03

1.11

5.91E-01

0.76

6.08E-02

3.87 2.56 2.01

1.00E-02 9.14E-04 8.85E-05

0.90 0.82 1.04

6.70E-01 4.60E-02 4.29E-01

1.14 1.41 1.08

1.03E-01 3.74E-01 4.51E-01

0.66 3.13

9.25E-04 4.00E-04

1.08 0.96

9.31E-02 5.48E-01

1.35 0.66

2.80E-02 1.78E-02

0.80 0.20 1.14 3.04 1.06 0.73

9.74E-03 2.31E-05 3.28E-01 5.40E-03 7.90E-01 1.63E-02

1.19 4.72 1.25 1.85 2.80 1.68

1.03E-01 9.56E-02 1.37E-01 2.03E-01 4.80E-02 1.14E-01

0.63 4.58 0.92 1.04 1.06 1.28

1.11E-02 3.08E-02 7.18E-01 6.12E-01 6.02E-01 3.78E-01


HPP family protein rnhA RNase H AraC-family protein transcriptional regulator NAD(P)H dehydrogenase, quinone family protein conserved hypothetical protein transcriptional regulator transcriptional regulator, TetR family protein clavaldehyde dehydrogenase clavaldehyde dehydrogenase DNA ligase ABC transporter ATP-binding protein sugar ABC transporter permease protein sugar ABC transporter permease protein substrate binding protein repressor D-mannonate oxidoreductase fructokinase hypothetical protein MarR-family protein transcriptional regulator Ku protein conserved hypothetical integral membrane protein hypothetical protein HNH endonuclease short chain dehydrogenase hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein manganese transport protein MntH carboxylate-amine ligase Nfa27300 conserved hypothetical protein conserved hypothetical protein pyruvate dehydrogenase ferredoxin-dependent glutamate synthase MarR-family protein transcriptional regulator oxidoreductase transcriptional regulator, TetR family protein hypothetical protein

1.94 0.63 0.98 1.22 3.61 0.86 1.72 12.30 14.46 1.50 1.57 1.60 1.75 1.94 2.01 1.36 1.58 1.05 1.05 1.64 1.54 16.68 0.84 1.33 1.03 1.53 0.92 0.96 1.39 2.17 1.06 0.97 0.82 0.66 0.91 1.16 1.49 0.92


1.35 1.33 1.35 1.15 0.64 0.95 0.84 0.45 0.46 1.11 1.15 1.42 1.38 1.57 1.37 1.17 1.21 1.35 1.29 0.84 1.04 1.04 1.30 1.11 0.83 1.02 0.59 0.76 0.80 0.98 0.92 0.76 1.04 1.20 0.63 1.27 0.82 1.07


1.04 1.05 1.08 1.32 0.99 1.40 0.79 1.80 1.44 0.99 0.13 0.25 0.21 0.24 0.34 0.46 0.74 1.00 0.96 0.68 1.64 0.91 2.88 1.14 1.36 0.80 0.64 0.50 0.38 0.22 0.38 0.58 0.91 2.11 0.96 0.93 1.71 1.23



conserved hypothetical protein hypothetical protein conserved hypothetical protein transcriptional regulator, ArsR family protein integral membrane protein cytochrome bd ubiquinol oxidase, subunit I cytochrome bd-I oxidase subunit II hypothetical protein acetyl-CoA acetyltransferase carotenoid oxygenase putative transcriptional regulator family protein spore protein amino-acid acetyltransferase probable conserved transmembrane protein conserved hypothetical protein conserved hypothetical protein glyoxalase/bleomycin resistance protein/dioxygenase immunogenic protein MPT63 acyl-CoA dehydrogenase acyl-CoA dehydrogenase domain protein enoyl-CoA hydratase putative acyl-CoA dehydrogenase putative acyl-CoA dehydrogenase L-carnitine dehydratase/bile acid-inducible protein F oxidoreductase, short chain dehydrogenase/reductase family protein cyclododecanone monooxygenase luciferase Rieske [2Fe-2S] domain protein oxidoreductase, short chain dehydrogenase/reductase family protein conserved hypothetical protein transcriptional regulator, GntR family protein AMP-dependent synthetase and ligase oxidoreductase, short chain dehydrogenase/reductase family protein

0.98 0.87 0.81 1.22 1.01 1.24 1.17 1.42 1.23 2.48 1.23 4.42 0.87 0.48 1.42 1.08


0.92 1.18 0.94 1.05 1.48 1.41 2.55 1.86 1.80 0.92 1.27 0.76 1.00 1.04 0.94 1.06


1.03 1.00 2.46 1.02 1.13 1.52 1.16 0.82 1.00 1.22 1.23 1.52 0.89 2.27 0.68 0.91


1.70 0.69 1.65 1.21 1.13 1.43 1.44

1.28E-02 3.45E-01 1.43E-01 3.90E-01 2.96E-01 1.27E-01 2.25E-01

1.01 1.34 1.99 8.80 1.36 1.04 1.52

9.15E-01 1.15E-01 4.05E-01 3.16E-01 1.73E-02 8.50E-01 2.43E-01

0.77 0.80 1.00 1.00 1.03 1.01 1.01

1.89E-01 2.52E-01 9.81E-01 9.47E-01 5.18E-01 9.60E-01 5.95E-01

1.19

3.07E-01

1.14

4.41E-01

0.95

5.95E-01

1.09 1.17 1.82 1.05

2.13E-01 1.71E-01 2.04E-01 2.71E-01

12.95 0.96 1.24 1.77

3.90E-01 6.49E-01 8.27E-02 7.73E-02

1.18 0.97 0.93 1.16

5.10E-01 8.14E-01 2.22E-01 5.89E-01

1.08 0.94 0.92 1.04

3.82E-01 4.70E-01 4.10E-01 6.08E-01

1.95 1.01 1.30 1.28

1.48E-01 9.10E-01 4.76E-02 5.24E-01

1.19 1.11 0.89 1.18

2.92E-01 4.93E-01 3.14E-01 5.54E-01

0.92

3.16E-01

1.14

3.43E-01

0.92

1.40E-01


feruloyl-CoA synthetase conserved hypothetical protein conserved hypothetical protein P-type ATPase - metal cation transport penicillin-binding protein 4 metallo-beta-lactamase family protein enoyl-CoA hydratase amylo-alpha-1,6-glucosidase glycosyl transferase, group 1 family protein acetyl-coenzyme a carboxylase carboxyl transferase conserved hypothetical protein membrane protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error hypothetical protein acyl-CoA synthase AMP-dependent synthetase and ligase transcriptional regulator, LuxR family protein alpha/beta hydrolase fold cytosine/purine/uracil/thiamine/allantoin permease family protein transcriptional regulator, LysR family protein hydrolase, carbon-nitrogen family protein hisD histidinol dehydrogenase transcriptional regulator, LysR family protein epoxide hydrolase ABC transporter, ATP-binding protein ABC transporter ATP-binding protein ABC transporter ATP-binding protein prrA DNA-binding response regulator PrrA sensor-type histidine kinase PrrB binding protein hypothetical protein conserved hypothetical protein

1.08 0.72 0.97 0.45 0.88 0.59 0.88 1.51 1.25

4.97E-01 2.16E-02 7.43E-01 4.84E-04 3.32E-01 2.62E-04 1.90E-01 1.20E-02 1.85E-02

0.99 1.07 1.11 1.26 0.99 0.95 0.70 1.06 0.80

8.09E-01 1.15E-01 1.57E-01 6.87E-02 8.06E-01 5.09E-01 1.04E-02 4.91E-01 1.20E-02

1.57 1.06 1.70 1.11 1.44 1.78 1.16 1.11 0.98

7.79E-02 6.28E-01 2.13E-02 3.94E-01 5.74E-02 1.80E-01 5.73E-02 2.77E-01 5.63E-01

0.97 1.05 0.59 0.55 1.14

6.08E-01 6.46E-01 1.70E-03 4.64E-05 7.34E-01

0.93 1.10 1.32 1.52 0.96

8.08E-02 3.34E-01 6.19E-02 8.09E-03 7.89E-01

1.37 1.10 1.14 1.08 1.54

4.55E-02 2.37E-01 1.75E-01 3.87E-01 1.77E-01

1.62 1.21 3.75 5.21 3.73 0.97

7.78E-03 6.19E-02 3.78E-03 3.04E-03 8.25E-04 7.30E-01

0.76 0.90 1.50 1.50 0.89 1.53

2.93E-04 2.09E-01 2.85E-02 6.47E-02 2.83E-01 1.10E-01

1.67 0.85 0.13 0.12 0.10 1.10

1.19E-01 6.14E-02 9.06E-05 9.30E-06 1.04E-05 2.18E-01

1.05 1.09 0.98 0.89 1.29 0.90 0.81 0.87 0.83 0.74 1.06 0.70 1.36 3.12

7.15E-01 2.60E-01 3.82E-01 3.48E-01 1.78E-01 4.80E-01 1.36E-01 2.11E-01 4.79E-02 1.82E-03 3.16E-01 1.91E-04 2.06E-01 3.41E-03

1.55 1.24 1.56 1.31 1.49 0.86 1.34 1.95 4.74 0.89 0.86 0.84 1.44 0.79

2.85E-01 3.65E-01 1.16E-01 3.55E-01 2.95E-01 1.59E-02 2.58E-01 1.30E-01 1.27E-01 5.49E-02 9.61E-02 1.85E-01 3.30E-01 1.64E-02

3.32 1.02 20.57 1.79 1.01 0.76 1.12 1.87 0.95 1.21 1.61 0.60 0.86 5.93

1.80E-01 6.92E-01 1.08E-01 1.18E-01 8.56E-01 7.09E-02 3.64E-01 7.68E-02 7.37E-01 9.12E-02 2.53E-01 3.50E-05 2.90E-01 4.03E-01


phytoene dehydrogenase putative transcriptional regulator efflux membrane protein YbaK/prolyl-tRNA synthetase associated region citrate synthase I transcriptional regulator membrane transport protein pyridoxamine 5'-phosphate oxidase citrate synthase conserved hypothetical protein glyoxalase/bleomycin resistance protein/dioxygenase putative DNA-binding protein glyoxalase family protein probable ferredoxin/ferredoxin--NADP reductase conserved hypothetical protein methionine aminopeptidase, type I phosphoserine aminotransferase, putative DNA-binding protein conserved hypothetical protein 23s ribosomal RNA methyltransferase regulatory protein, MarR conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein transporter, major facilitator family protein conserved hypothetical protein glutathione S-transferase 'Cold-shock' DNA-binding domain protein integral membrane protein molybdenum cofactor biosynthesis protein A ThiS family protein secreted protein molybdopterin converting factor, subunit 2 molybdenum cofactor synthesis domain protein molybdenum cofactor biosynthesis protein C conserved hypothetical protein

gltA pdxH

map

moaA moaE moaC

1.81 1.45 0.99 0.82 0.40 2.71 0.83 0.87 0.98 0.61

3.09E-02 2.01E-01 9.52E-01 1.47E-01 7.50E-06 8.69E-05 5.40E-01 1.58E-02 5.40E-01 5.54E-04

0.86 1.02 1.45 1.09 0.77 1.28 1.74 1.20 0.91 0.87

1.35E-01 8.64E-01 5.93E-02 6.39E-01 1.58E-01 1.27E-01 2.03E-01 8.82E-02 1.33E-01 4.87E-02

1.13 1.16 1.39 0.98 1.37 1.09 2.79 1.42 1.42 2.37

7.77E-01 3.14E-01 4.47E-01 6.17E-01 2.45E-01 7.57E-01 2.54E-04 5.50E-02 4.21E-03 5.70E-03

0.98 1.03 1.91 3.35 6.08 1.61 0.43 1.39 1.24 0.39 0.61 1.21 1.42 1.20 1.12 2.67 0.77 1.74 0.45 1.48 1.91 2.59 1.05 0.93 0.63 0.65 0.84


0.84 0.89 0.77 0.61 0.65 0.80 1.04 1.02 0.85 1.12 1.22 0.82 0.75 0.69 1.71 0.86 0.87 1.21 1.08 1.07 0.72 0.90 1.09 0.93 0.93 1.30 0.75


0.82 0.59 1.27 3.88 2.86 1.24 0.93 1.31 1.26 4.14 1.06 1.32 0.69 1.72 0.99 6.44 1.37 0.66 0.69 1.84 1.53 0.88 1.99 1.72 1.04 1.99 0.78



conserved hypothetical protein DNA or RNA helicase of superfamily protein II cupin domain protein hypothetical protein conserved hypothetical protein hypothetical protein oxidoreductase, short chain dehydrogenase/reductase family protein LysR-family protein transcriptional regulator major facilitator family protein transporter short-chain dehydrogenase/reductase SDR conserved hypothetical protein hypothetical protein pyridoxamine 5'-phosphate oxidase family transcriptional regulator, TetR family protein oxidoreductase putative 3-hydroxyacyl-CoA dehydrogenase acetyl-CoA acetyltransferase conserved hypothetical protein endoribonuclease L-psp family protein bacterial regulatory protein, MarR family protein PLP-dependent aminotransferases conserved hypothetical protein alc allantoicase polysaccharide deacetylase family protein hydantoin racemase permease for cytosine/purines, uracil, thiamine, allantoin transporter transcriptional regulator, GntR family protein monooxygenase universal stress protein family protein alpha-methylacyl-CoA racemase indole-3-pyruvate decarboxylase cyclase/dehydrase hypothetical protein conserved hypothetical protein putative long-chain fatty-acid--CoA ligase hypothetical protein

0.95 0.88 0.77 0.85 0.75 0.73

4.53E-01 1.95E-02 1.02E-03 9.16E-03 1.65E-02 8.53E-03

0.88 0.80 0.85 0.99 1.26 1.35

2.38E-01 6.33E-02 5.29E-02 7.74E-01 1.20E-01 9.11E-02

1.16 1.14 1.23 0.86 0.69 0.38

3.18E-01 1.06E-01 1.48E-01 4.76E-02 3.25E-02 1.30E-03

1.22 1.26 1.37 1.63 1.46 1.75 1.56 1.18 0.91 2.14 1.65 1.67 0.82 1.28 0.75 0.69 0.72 0.80 0.57


1.33 0.94 0.88 0.67 0.75 0.92 0.79 1.05 0.84 0.83 1.04 4.92 4.30 0.96 0.82 0.96 0.85 0.83 1.19


1.60 0.99 2.60 4.05 0.64 1.80 0.15 1.00 1.02 2.37 1.93 0.62 0.96 1.72 1.77 1.42 1.15 1.34 0.75


0.21 0.76 1.95 1.51 0.57 2.01 1.63 1.18 1.92 1.34 0.85

1.19E-04 2.59E-02 4.04E-03 2.91E-02 2.08E-05 7.43E-02 2.67E-04 3.91E-02 4.70E-03 1.21E-01 8.17E-03

1.15 1.22 1.21 5.66 0.87 0.93 1.10 1.25 0.83 0.98 1.06

2.63E-01 1.66E-01 3.55E-01 1.10E-03 2.45E-01 5.70E-01 3.04E-01 2.82E-01 8.04E-02 5.96E-01 6.29E-01

0.81 0.80 1.26 5.35 0.98 0.95 0.40 1.22 0.93 1.11 0.92

2.99E-01 2.11E-01 3.34E-01 1.73E-02 9.19E-01 7.36E-01 4.82E-04 3.40E-01 2.91E-01 1.50E-01 3.46E-01


conserved hypothetical protein acyltransferase domain protein patatin gas vesicle protein K gas vesicle synthesis protein gas vesicle protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein putative adhesin/hemolysin conserved hypothetical protein serine/threonine specific protein phosphatase gp41 protein pe family protein GntR-family protein regulator cupin domain protein zinc-binding oxidoreductase conserved hypothetical protein putative cyanamide hydratase globin conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein cytospin-A, putative fatty acid desaturase tRNA-dihydrouridine synthase, putative LytR/CpsA/Psr family protein phosphate transport system regulatory protein PhoU transcription regulator alcohol dehydrogenase, zinc-binding phosphate ABC transporter, ATP-binding protein phosphate ABC transporter, permease protein PstA

0.76 1.29 1.67 2.57 0.95 0.90 0.79 0.86 1.16 1.24 1.33 0.84 0.59 1.41 1.01 1.79 4.03 2.35 3.84 1.64 0.45 0.62 1.56 0.91 0.68 1.06 0.73 1.21 0.78 1.09 1.53


0.91 0.82 1.15 1.05 0.98 1.40 1.16 1.06 0.91 0.91 0.81 0.83 1.21 0.95 0.95 1.10 1.00 0.84 0.99 0.88 1.32 1.12 0.58 0.89 0.89 0.76 0.97 1.10 2.01 1.36 0.62


0.75 1.14 1.06 0.65 1.30 0.96 1.24 2.16 0.83 1.40 1.34 0.84 1.07 0.96 1.08 1.07 1.06 1.09 1.06 1.25 1.13 0.77 0.83 0.98 1.54 0.34 0.45 0.94 7.33 4.88 0.96


pstB

2.40 1.37 1.16 2.08

1.02E-03 1.64E-01 7.10E-03 1.75E-01

0.97 0.99 0.98 0.82

7.29E-01 9.22E-01 6.33E-01 1.29E-01

0.58 1.07 1.14 1.74

3.93E-04 6.09E-01 3.52E-01 2.32E-02

pstA

1.17

4.95E-02

0.70

1.10E-02

2.20

5.03E-02

gvpK

phoU

MSMEG_5781 phosphate ABC transporter, permease protein PstC MSMEG_5782 phosphate ABC transporter, phosphate-binding protein PstS MSMEG_5783 acetyltransferase, GNAT family; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00583 MSMEG_5784 transcriptional regulatory protein MSMEG_5785 probable exported protein MSMEG_5786 thiredoxin MSMEG_5787 hypothetical protein MSMEG_5788 integral membrane protein MSMEG_5789 putative thiosulfate sulfurtransferase MSMEG_5790 SseC protein MSMEG_5791 conserved hypothetical protein MSMEG_5792 conserved hypothetical protein MSMEG_5793 hypothetical protein MSMEG_5794 hypothetical protein MSMEG_5795 4-amino-4-deoxychorismate lyase MSMEG_5796 Glycine cleavage T-protein (aminomethyl transferase) MSMEG_5797 conserved hypothetical protein MSMEG_5798 phosphoribosylformylglycinamidine cyclo-ligase MSMEG_5799 nucleoside-diphosphate-sugar epimerase MSMEG_5800 amidophosphoribosyltransferase MSMEG_5801 hydroxylase MSMEG_5802 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5803 hypothetical protein MSMEG_5804 conserved hypothetical protein MSMEG_5805 hypothetical protein MSMEG_5806 hypothetical protein MSMEG_5807 D-methionine transport ATP-binding protein MetN MSMEG_5808 binding-protein-dependent transport systems inner membrane component MSMEG_5809 lipoprotein YaeC, putative

pstC

1.25

1.13E-02

0.83

9.52E-03

1.43

1.78E-02

pstS

0.90

2.70E-01

0.96

7.30E-01

1.01

9.28E-01

0.62 1.31 0.43 0.70 0.87 0.76 0.62 0.61 0.57 0.50 0.46 1.21 1.16

5.93E-04 2.68E-03 4.65E-04 9.68E-04 3.52E-01 2.25E-02 5.34E-04 4.13E-03 8.10E-05 6.53E-05 6.74E-07 6.88E-01 3.88E-02

2.54 0.95 1.05 0.96 0.98 1.84 1.57 1.38 0.97 1.05 0.92 0.64 0.84

1.06E-01 5.39E-01 5.11E-01 5.58E-01 7.73E-01 1.46E-01 1.15E-01 2.64E-01 8.13E-01 4.99E-01 1.09E-02 9.17E-02 1.58E-01

1.56 0.84 1.65 0.98 1.33 2.34 1.85 2.87 1.73 1.61 2.21 1.21 1.10

2.21E-01 1.61E-01 7.86E-02 8.05E-01 3.37E-01 1.44E-01 8.02E-03 1.59E-02 5.35E-03 8.86E-03 2.40E-02 4.68E-01 5.89E-01

1.77 1.74 0.67 1.62 2.04 1.20

1.12E-03 9.82E-05 6.40E-03 4.15E-01 1.28E-03 1.70E-01

0.69 0.71 0.87 1.03 0.70 1.04

2.05E-03 1.83E-02 7.53E-02 6.06E-01 1.70E-02 7.99E-01

0.80 1.89 0.81 1.00 1.49 0.99

5.61E-02 6.39E-02 3.87E-03 9.49E-01 1.05E-01 7.72E-01

0.88 1.01 0.69 0.65 2.46

3.93E-01 9.13E-01 1.98E-02 3.16E-03 9.28E-02

1.06 0.98 0.74 1.13 1.11

3.66E-01 7.97E-01 5.29E-02 1.07E-01 3.63E-01

1.55 0.95 1.49 1.57 5.18

8.35E-02 5.66E-01 1.31E-01 2.50E-01 3.72E-01

0.94

7.53E-01

2.28

2.44E-01

1.09

1.53E-01

1.20 0.98

3.02E-01 8.19E-01

1.67 1.97

4.57E-02 2.52E-01

1.00 1.27

9.74E-01 1.73E-01

purM purF


putative monooxygenase transcriptional regulator, TetR family protein carveol dehydrogenase carveol dehydrogenase 4-carboxymuconolactone decarboxylase domain protein betaine aldehyde dehydrogenase conserved hypothetical protein conserved hypothetical protein virulence factor Mce family protein pyridoxamine 5'-phosphate oxidase family hypothetical protein caax amino protease family protein conserved hypothetical protein conserved membrane-spanning protein phosphoribosylformylglycinamidine synthase II Na+/H+ antiporter pyruvate decarboxylase glyoxalase family protein aspartyl aminopeptidase Dyp-type peroxidase 29 kda antigen Cfp29 phosphoribosylformylglycinamidine synthase I phosphoribosylformylglycinamidine synthase, PurS protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error metallo-beta-lactamase superfamily protein fumarate reductase/succinate dehydrogenase flavoprotein conserved hypothetical protein glutathione peroxidase family protein TetR-family protein transcriptional regulator protease 2 conserved hypothetical protein phosphoribosylaminoimidazolesuccinocarboxamide synthase

1.13 0.85 1.35 1.41

5.52E-01 1.25E-01 6.77E-02 3.85E-01

1.98 1.20 0.76 0.98

3.33E-01 2.87E-01 5.84E-02 7.42E-01

1.17 0.98 1.05 1.12

1.44E-01 2.39E-01 3.70E-01 4.90E-01

purQ

0.88 0.74 0.64 1.04 1.01 1.52 0.99 0.62 1.25 0.82 0.64 0.80 1.14 0.59 0.49 0.96 0.88 0.51


0.87 1.18 0.67 1.04 0.98 1.14 1.00 1.05 0.99 1.09 1.05 0.94 1.32 0.77 0.86 0.96 1.03 0.95


1.01 1.15 0.96 1.36 1.04 0.87 2.00 1.66 1.03 2.16 1.64 0.94 0.69 1.17 1.69 0.56 0.53 0.87


purS

0.67

3.50E-04

0.97

5.74E-01

1.40

8.76E-02

1.40 0.99

9.39E-02 8.88E-01

1.12 1.11

3.18E-01 1.70E-01

0.95 0.65

6.38E-01 7.04E-04

1.02 0.50 0.66 0.94 0.52 0.95

7.12E-01 3.53E-02 3.01E-04 2.60E-01 3.42E-05 3.54E-01

0.87 1.36 0.95 0.90 0.90 1.62

2.19E-01 2.37E-01 5.95E-01 9.88E-03 3.74E-02 1.67E-01

0.57 1.15 0.92 1.89 1.44 0.92

4.42E-02 5.82E-01 6.32E-01 4.13E-01 1.51E-01 2.53E-01

0.54

3.60E-05

1.00

9.70E-01

0.88

3.57E-01

pcaC

purL

purC


conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein putative C4-dicarboxylate transporter NikQ protein adenylosuccinate lyase amino acid permease-associated region conserved hypothetical protein transcriptional regulator, TetR family protein putative esterase superfamily protein phosphoribosylamine--glycine ligase cytochrome P450 transcriptional regulator, TetR family protein conserved hypothetical protein 4-carboxymuconolactone decarboxylase domain protein hypothetical oxidoreductase 3-oxoacyl-[acyl-carrier-protein] reductase aldehyde dehydrogenase (NAD) family protein transcriptional regulator, TetR family protein cytochrome P450 109 short chain dehydrogenase cytochrome P450 51 cytochrome P450 51 conserved hypothetical protein alcohol dehydrogenase B nuclear transport factor 2 (NTF2) domain superfamily protein hypothetical protein putative short chain dehydrogenase sensor histidine kinase PhoR HIT family protein DNA-binding response regulator PhoP conserved hypothetical protein hypothetical protein H-N-H endonuclease F-TflIV conserved hypothetical protein serine esterase, cutinase family protein

purB

purD

pcaC

phoP

1.75 0.76 0.94 0.62 0.78 0.50 1.17 1.64 6.68 1.13 0.38 1.45 0.79 0.70

2.93E-02 5.57E-02 6.23E-01 2.50E-02 6.24E-02 3.89E-05 3.55E-01 3.28E-03 1.34E-02 2.02E-01 2.54E-05 8.93E-02 1.54E-01 2.74E-02

1.12 0.73 1.22 1.12 0.90 0.86 1.12 0.89 1.58 0.70 0.79 0.94 1.04 1.02

8.58E-02 4.29E-02 1.41E-01 2.34E-01 2.92E-01 4.73E-02 1.56E-01 7.95E-02 2.83E-02 4.16E-03 5.82E-02 6.78E-01 5.36E-01 8.98E-01

1.19 0.93 0.87 1.12 1.10 1.34 0.67 1.19 0.08 1.45 2.75 0.94 1.27 0.92

3.33E-01 1.63E-01 3.48E-01 6.02E-01 5.14E-01 4.17E-02 2.36E-02 1.78E-01 4.72E-08 2.33E-01 1.40E-02 5.72E-01 2.46E-01 4.64E-01

0.83 0.94 0.83 0.84 1.74 0.84 1.27 0.93 0.71 1.08 3.82

5.21E-02 7.57E-01 1.01E-01 1.28E-01 2.93E-01 1.18E-01 4.40E-01 5.34E-01 7.07E-02 1.62E-01 5.30E-03

1.05 1.01 1.00 1.15 1.24 0.94 1.02 1.04 1.09 1.11 0.97

6.35E-01 8.42E-01 9.96E-01 2.04E-01 8.77E-02 4.79E-01 6.83E-01 8.40E-01 4.13E-01 3.87E-01 7.82E-01

1.03 1.26 0.82 0.93 1.01 1.00 1.00 0.99 1.79 1.02 0.08

8.19E-01 4.39E-01 1.79E-01 4.56E-01 8.62E-01 9.11E-01 8.64E-01 6.06E-01 4.17E-01 5.67E-01 8.12E-07

3.09 0.98 1.19 0.73 0.70 2.38 1.46 1.02 0.77 1.49 6.13

7.73E-02 8.63E-01 1.94E-01 1.95E-05 7.32E-05 1.89E-03 1.35E-03 8.87E-01 1.72E-01 9.30E-02 2.99E-05

1.26 1.03 1.15 0.79 1.04 0.84 0.90 1.09 0.95 0.72 0.79

4.25E-01 5.68E-01 1.74E-01 4.84E-02 6.14E-01 1.52E-03 2.21E-02 5.57E-01 6.33E-01 2.23E-01 3.94E-02

0.24 8.04 0.72 0.98 0.80 0.22 0.61 0.55 1.20 0.92 1.46

1.17E-04 9.91E-03 1.04E-01 8.88E-01 6.24E-02 3.70E-05 4.25E-04 8.14E-03 4.27E-01 7.97E-01 5.64E-03

MSMEG_5879 D-alanyl-D-alanine dipeptidase MSMEG_5880 nicotine dehydrogenase MSMEG_5881 putative carbon monoxide dehydrogenase subunit G MSMEG_5882 carbon monoxide dehydrogenase medium chain MSMEG_5883 [2Fe-2S] binding domain protein MSMEG_5884 3-hydroxyisobutyrate dehydrogenase family protein MSMEG_5885 short chain dehydrogenase MSMEG_5886 enoyl-CoA hydratase MSMEG_5887 intersectin-EH binding protein Ibp1 MSMEG_5888 conserved hypothetical protein MSMEG_5889 conserved hypothetical protein MSMEG_5890 conserved hypothetical protein MSMEG_5892 alpha,alpha-trehalose-phosphate synthase (UDPforming) MSMEG_5893 conserved hypothetical protein MSMEG_5894 conserved hypothetical protein MSMEG_5895 virulence factor mce family protein MSMEG_5896 virulence factor Mce family protein MSMEG_5897 virulence factor mce family protein MSMEG_5898 virulence factor Mce family protein MSMEG_5899 virulence factor Mce family protein MSMEG_5900 virulence factor Mce family protein MSMEG_5901 TrnB2 protein MSMEG_5902 conserved hypothetical protein MSMEG_5903 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5904 conserved domain protein MSMEG_5905 hypothetical protein MSMEG_5906 putative acyl-CoA dehydrogenase MSMEG_5907 acyl-CoA dehydrogenase MSMEG_5908 acyl-CoA synthase MSMEG_5909 oxidoreductase MSMEG_5910 quinone binding protein MSMEG_5911 AraC family protein transcriptional regulator MSMEG_5912 succinic semialdehyde dehydrogenase MSMEG_5913 dioxygenase

0.77 0.95

2.75E-03 7.51E-01

0.93 1.09

3.54E-01 5.44E-01

0.85 0.97

1.16E-01 5.09E-01

1.42 0.89 0.97

4.53E-01 1.39E-01 7.67E-01

1.16 1.18 1.17

2.77E-01 3.04E-01 3.09E-01

0.89 1.10 1.34

4.31E-01 6.52E-01 3.71E-01

1.99 1.87 0.80 3.59 0.68 0.93 1.21

1.64E-03 7.98E-03 1.25E-01 9.24E-04 9.23E-04 4.85E-01 1.29E-01

0.68 0.58 1.09 0.53 1.36 0.92 0.92

4.06E-03 2.88E-02 3.15E-01 1.84E-02 8.11E-03 6.34E-01 3.52E-01

1.02 0.95 1.47 0.21 1.20 0.37 1.44

8.81E-01 8.12E-01 4.07E-01 1.11E-04 4.52E-01 1.63E-05 3.03E-02

0.94 0.52 0.45 0.55 0.54 0.52 0.55 0.47 0.56 0.50 0.70

3.52E-01 9.31E-05 5.00E-06 1.13E-04 1.11E-03 1.42E-04 2.04E-04 9.32E-05 3.34E-04 4.08E-04 2.93E-02

0.89 1.11 1.16 1.12 1.15 1.29 1.18 1.14 1.05 1.19 0.94

1.07E-01 3.09E-01 3.20E-01 2.41E-01 1.78E-01 5.05E-02 5.62E-02 2.56E-01 5.19E-01 1.65E-01 5.92E-01

1.62 1.04 0.80 0.37 0.57 0.49 0.64 0.78 0.66 0.86 0.61

3.84E-04 8.66E-01 2.32E-01 1.14E-03 6.04E-03 1.94E-02 6.07E-02 8.74E-02 1.05E-01 6.08E-01 1.22E-03

0.95 0.86 1.38 3.26 2.62 1.50 2.02 1.38 2.44 2.23 1.58

1.53E-01 4.88E-02 1.82E-01 2.98E-02 4.77E-02 4.71E-02 3.48E-02 2.97E-03 1.38E-03 8.37E-03 9.95E-02

0.80 1.25 1.13 0.90 0.99 1.14 1.10 0.65 0.73 0.95 0.80

7.29E-06 5.63E-02 5.49E-01 6.86E-01 9.67E-01 5.55E-01 3.46E-01 6.55E-03 1.92E-02 4.63E-01 1.91E-01

1.02 1.57 0.95 0.77 1.05 1.42 1.17 0.61 2.67 1.26 0.91

9.26E-01 1.50E-02 3.48E-01 1.75E-01 7.36E-01 1.70E-01 2.88E-01 2.65E-03 1.93E-02 4.58E-02 6.79E-01


acyl-CoA synthase enoyl-CoA hydratase hypothetical protein conserved hypothetical protein P450 heme-thiolate protein conserved hypothetical protein FMN-dependent monooxygenase conserved hypothetical protein lipid-transfer protein acetyl-CoA acetyltransferase conserved hypothetical protein Rieske [2Fe-2S] domain protein putative secreted protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein short chain dehydrogenase conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein ATP-dependent DNA helicase conserved hypothetical protein 4-hydroxy-2-oxovalerate aldolase hypothetical protein acetaldehyde dehydrogenase 2-keto-4-pentenoate hydratase 3-ketosteroid dehydrogenase AMP-dependent synthetase and ligase putative peroxisomal multifunctional enzyme type 2 glucose-methanol-choline oxidoreductase conserved hypothetical protein hypothetical protein serine O-acetyltransferase glycosyl transferase conserved hypothetical protein

cysE

1.30 1.76 2.35 1.44 1.63 1.24 1.16 1.32 1.19 1.29 1.51 0.94 1.13 0.84 1.06 0.67 0.66 0.78 0.90 0.88 3.06 0.59 0.59 1.39 0.89 1.09 0.74 0.30 1.00


0.94 0.77 0.60 0.95 0.95 0.88 0.94 0.64 0.74 0.68 0.89 0.73 1.16 0.77 0.97 0.82 1.07 1.01 1.08 1.47 0.95 0.96 1.58 0.82 0.96 0.72 0.91 1.06 1.21


0.86 1.12 2.02 1.06 0.89 1.13 1.49 0.58 0.86 1.19 1.89 1.14 0.96 2.25 1.05 1.12 0.95 1.04 1.06 1.23 0.63 2.07 0.52 0.51 0.98 0.44 0.50 0.75 0.93


0.43 1.64 3.72 1.29 1.31 2.77 1.90

1.32E-04 1.54E-01 2.65E-02 2.20E-01 2.63E-01 1.51E-01 6.95E-02

0.82 0.96 0.51 1.00 0.83 0.97 1.09

8.19E-02 2.54E-01 1.03E-03 9.53E-01 7.85E-02 7.48E-01 2.37E-01

0.67 0.93 0.82 1.03 0.67 0.98 0.84

2.24E-01 7.19E-01 1.54E-01 2.54E-03 8.40E-02 6.35E-01 1.36E-01

MSMEG_5950 putative colanic acid biosynthesis acetyltransferase WcaF MSMEG_5951 glycosyl transferase, group 1, putative MSMEG_5952 conserved hypothetical protein, putative MSMEG_5953 hypothetical protein MSMEG_5954 cell surface polysaccharide biosynthesis, putative MSMEG_5955 protein-tyrosine kinase, putative MSMEG_5956 NAD dependent epimerase/dehydratase family protein algD MSMEG_5957 GDP-mannose 6-dehydrogenase AlgD MSMEG_5958 hypothetical protein MSMEG_5959 conserved hypothetical protein MSMEG_5960 O-antigen polymerase, putative MSMEG_5961 glycosyl transferase, group 2 family protein, putative MSMEG_5962 glycosyl transferase, family protein 2 MSMEG_5963 glycosyl transferase, family protein 2 MSMEG_5964 glycosyl transferase, group 1, putative MSMEG_5965 hypothetical protein MSMEG_5966 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5967 glucose-methanol-choline oxidoreductase MSMEG_5968 polysaccharide biosynthesis protein MSMEG_5969 conserved hypothetical protein MSMEG_5970 probable glutamate-1-semialdehyde 2,1aminomutase MSMEG_5971 conserved hypothetical protein MSMEG_5972 hypothetical protein MSMEG_5973 hypothetical protein MSMEG_5974 hypothetical protein MSMEG_5975 methyltransferase type 12, putative MSMEG_5976 epimerase/dehydratase rfbC MSMEG_5977 dTDP-4-dehydrorhamnose 3,5-epimerase MSMEG_5978 GlcNAc-PI de-N-acetylase family protein MSMEG_5979 transferase MSMEG_5980 methyltransferase MSMEG_5981 glycosyl transferase, putative MSMEG_5982 UDP-glucose 6-dehydrogenase

1.77 1.70 1.44 1.12 1.45 1.66

4.47E-02 1.68E-01 2.64E-01 5.15E-01 7.64E-02 9.68E-02

0.88 1.17 0.97 1.14 1.24 0.88

3.08E-01 2.98E-01 6.54E-01 4.43E-02 1.78E-01 2.76E-02

0.87 0.97 0.61 0.89 0.82 0.64

2.08E-01 6.36E-01 3.90E-02 2.85E-01 2.18E-01 8.18E-02

1.24 2.43 1.15 0.86 1.58

1.44E-01 2.07E-01 2.36E-01 9.75E-02 1.73E-01

0.79 0.99 1.05 1.09 1.15

1.58E-01 8.92E-01 6.45E-01 4.00E-01 5.47E-01

0.64 0.58 0.61 0.60 0.86

1.24E-01 1.79E-01 1.23E-01 8.38E-02 4.75E-01

0.75 0.91 1.06 0.99 2.23

6.42E-03 1.94E-01 6.49E-01 6.99E-01 6.61E-03

1.14 1.20 1.00 0.90 1.12

2.80E-01 5.64E-02 9.76E-01 2.80E-01 4.69E-01

0.68 0.74 0.52 0.81 0.66

1.89E-02 1.19E-01 6.17E-02 2.26E-01 8.46E-02

1.06 1.36 1.59 2.03

6.31E-01 1.57E-01 2.67E-01 5.79E-03

1.00 1.18 0.79 0.77

9.99E-01 2.09E-01 1.13E-01 2.07E-01

0.46 0.57 1.53 1.17

3.12E-02 6.83E-02 9.91E-02 4.62E-01

5.79 2.04 1.74 1.38 2.51 1.41 1.38 1.14 1.36 1.63 0.90 0.95 1.55

8.61E-02 2.86E-02 1.14E-02 3.71E-01 4.13E-01 3.58E-02 2.60E-01 2.10E-01 2.68E-01 1.37E-01 4.93E-01 4.23E-01 7.22E-02

0.72 0.75 0.94 0.92 0.99 0.98 0.81 1.13 0.91 0.93 0.90 1.09 1.10

9.50E-02 1.63E-01 5.44E-01 5.64E-01 9.48E-01 8.83E-01 8.59E-02 3.15E-01 2.09E-02 3.04E-01 2.05E-01 6.73E-01 4.57E-01

0.86 0.68 0.82 0.93 1.42 1.22 0.94 0.96 1.07 1.16 1.15 1.07 0.92

1.30E-01 5.13E-02 1.75E-01 4.28E-01 2.93E-01 2.20E-01 2.64E-01 2.51E-01 6.64E-01 3.81E-01 5.18E-01 2.96E-01 2.80E-01

rfbA MSMEG_5983 glucose-1-phosphate thymidylyltransferase MSMEG_5984 undecaprenyl-phosphate galactosephosphotransferase MSMEG_5985 NAD dependent epimerase/dehydratase family protein MSMEG_5986 glucosamine--fructose-6-phosphate glmS aminotransferase, isomerizing MSMEG_5987 two-component regulator MSMEG_5988 hypothetical protein MSMEG_5989 hypothetical protein MSMEG_5990 lipid-transfer protein MSMEG_5991 MaoC like domain, putative MSMEG_5992 conserved hypothetical protein MSMEG_5993 putative acyl-CoA dehydrogenase MSMEG_5994 putative acyl-CoA dehydrogenase MSMEG_5995 P450 heme-thiolate protein MSMEG_5996 acetyl-CoA acetyltransferase MSMEG_5997 conserved hypothetical protein MSMEG_5998 conserved hypothetical protein MSMEG_5999 short chain dehydrogenase MSMEG_6000 short chain dehydrogenase MSMEG_6001 enoyl-CoA hydratase MSMEG_6002 coenzyme A transferase, subunit A MSMEG_6003 coenzyme A transferase, subunit B MSMEG_6004 oxidoreductase, 2-nitropropane dioxygenase family protein MSMEG_6005 conserved hypothetical protein MSMEG_6006 conserved hypothetical protein MSMEG_6007 cation diffusion facilitator family transporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_6007 cation diffusion facilitator family transporter; this gene contains a frame shift which is not the result of sequencing error MSMEG_6008 acetyl-CoA acetyltransferase MSMEG_6009 transcriptional regulator, TetR family protein MSMEG_6010 hypothetical protein MSMEG_6011 short chain dehydrogenase

1.68

5.74E-02

0.66

1.19E-02

1.03

4.91E-02

2.02

6.85E-02

1.61

3.02E-01

0.91

3.61E-01

1.41

3.03E-01

1.18

9.54E-02

1.40

2.51E-01

0.96 1.31 1.58 1.84 2.67 1.82 3.00 3.61 3.24 5.82 1.58 1.91 2.00 0.90 1.25 0.75 0.80 0.98


1.41 1.33 0.99 0.97 0.72 0.92 0.87 0.67 0.83 0.84 0.86 1.01 0.98 0.95 1.02 0.99 0.79 1.06


1.14 0.91 0.53 0.50 1.32 1.31 1.02 0.95 1.19 0.84 0.75 1.06 1.08 0.98 1.07 0.88 0.97 1.02


1.16 1.03 0.42

1.58E-01 7.54E-01 6.94E-06

0.91 0.97 0.97

3.30E-01 3.77E-01 7.64E-01

1.33 1.14 1.36

2.06E-01 6.08E-01 2.84E-01

1.33

3.67E-02

0.82

2.95E-02

1.13

1.23E-01

0.96 1.07 0.85 1.17 0.80

7.51E-01 3.84E-01 2.48E-02 1.14E-01 3.11E-02

1.24 0.86 1.07 0.88 0.88

2.52E-01 4.56E-02 3.83E-03 7.08E-02 1.41E-01

0.94 1.19 1.81 2.24 1.02

6.98E-01 3.12E-01 1.07E-01 3.72E-01 8.33E-01

MSMEG_6012 putative acyl-CoA dehydrogenase MSMEG_6013 probable fatty-acid-coa ligase fadd3 (fatty-acidcoa synthetase); this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM MSMEG_6013 probable fatty-acid-coa ligase fadd3 (fatty-acidcoa synthetase); this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM MSMEG_6014 putative acyl-CoA dehydrogenase MSMEG_6015 putative acyl-CoA dehydrogenase MSMEG_6016 putative acyl-CoA dehydrogenase MSMEG_6017 aminotransferase, class I MSMEG_6018 xylose transport system permease protein XylH MSMEG_6019 ABC-type sugar transport system ATPase component MSMEG_6020 D-xylose-binding periplasmic protein MSMEG_6021 xylose isomerase MSMEG_6022 xylose repressor, ROK-family protein transcriptional regulator MSMEG_6023 transposase MSMEG_6024 acetoacetyl-CoA synthase MSMEG_6025 conserved hypothetical protein MSMEG_6026 3-hydroxybutyrate dehydrogenase MSMEG_6027 major facilitator superfamily protein MFS_1 MSMEG_6028 transcriptional regulator, LysR family protein MSMEG_6029 conserved hypothetical protein MSMEG_6030 cytochrome p450 MSMEG_6031 carveol dehydrogenase MSMEG_6032 transcriptional regulator, TetR family protein MSMEG_6033 hypothetical protein MSMEG_6034 hypothetical protein MSMEG_6035 nitrilotriacetate monooxygenase component B MSMEG_6036 biphenyl-2,3-diol 1,2-dioxygenase MSMEG_6037 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase MSMEG_6038 pigment production hydroxylase MSMEG_6039 oxidoreductase, electron transfer component

0.96

6.44E-01

1.05

6.63E-01

1.06

8.37E-01

fadD

1.69

1.35E-02

0.83

4.87E-02

0.86

2.05E-01

fadD

1.28 1.98 1.74 2.67 0.93 2.92

3.86E-02 4.92E-03 1.48E-02 3.03E-02 3.39E-01 7.40E-04

1.06 0.90 0.90 0.95 0.92 0.99

4.40E-01 5.21E-01 2.35E-01 6.15E-01 1.17E-01 9.04E-01

1.01 0.98 1.67 0.85 2.24 0.13

6.97E-01 7.38E-01 3.18E-01 1.29E-01 1.26E-02 2.85E-06

2.50 2.43 3.17

4.88E-04 5.08E-05 2.67E-03

0.88 0.80 0.73

1.81E-02 7.85E-04 1.04E-03

0.10 0.16 0.32

7.88E-07 2.12E-06 3.97E-02

1.42 1.54 1.91 1.23 3.13 5.32 1.01 1.75 4.04 0.91 1.42 0.15 1.16 1.59 0.98


1.14 1.10 0.70 1.42 0.80 0.52 1.13 0.81 0.64 0.99 0.89 1.01 1.32 0.69 0.90


2.09 1.01 0.73 2.01 0.27 0.61 1.87 1.88 2.94 1.02 1.13 0.50 1.01 1.03 1.22


0.91 1.36 0.70

4.64E-01 5.54E-02 2.36E-02

0.98 0.94 0.85

8.35E-01 5.68E-01 6.75E-02

0.88 0.65 1.85

3.95E-01 3.34E-02 1.59E-01

xylA

MSMEG_6040 MSMEG_6041 MSMEG_6042 MSMEG_6043 MSMEG_6044 MSMEG_6045 MSMEG_6046 MSMEG_6047 MSMEG_6048 MSMEG_6049 MSMEG_6050 MSMEG_6051

MSMEG_6051


conserved hypothetical protein putative acyl-CoA dehydrogenase transcriptional regulator, TetR family protein otsB trehalose-phosphatase periplasmic binding proteins and sugar binding domain of the LacI family protein, putative ABC heavy metal transporter, inner membrane subunit cation ABC transporter, ATP-binding protein, putative cation ABC transporter, periplasmic cationbinding protein, putative cobalamin synthesis protein/P47K secreted protein solute-binding lipoprotein ABC transporter protein, integral membrane subunit; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00950 ABC transporter protein, integral membrane subunit; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00950 ABC transport protein, ATP-binding subunit bluB cob(II)yrinic acid a,c-diamide reductase LamB/YcsF hypothetical protein transposase; this gene contains a frame shift which is not the result of sequencing error transposase; this gene contains a frame shift which is not the result of sequencing error MspD protein cadmium transporting P-type ATPase conserved hypothetical protein permease conserved hypothetical protein Fe uptake system permease Fe uptake system integral membrane protein

0.94 2.17 1.71 0.81

4.89E-01 3.96E-03 5.73E-02 7.38E-02

1.10 0.78 1.66 1.23

2.95E-01 1.27E-02 1.80E-01 3.83E-01

0.72 0.87 0.84 0.92

1.21E-01 2.87E-02 5.46E-02 5.08E-01

0.63

2.10E-03

0.99

8.46E-01

1.88

4.72E-02

1.13

3.86E-01

0.91

5.36E-01

1.18

5.22E-01

1.11

3.61E-01

1.27

4.30E-01

0.88

1.81E-01

0.59 1.10 0.54 1.14

5.60E-03 6.49E-01 1.06E-02 1.52E-01

0.92 2.23 1.09 0.98

2.09E-01 5.59E-02 1.16E-01 8.86E-01

2.78 1.44 1.04 0.99

1.97E-01 4.85E-01 6.02E-01 8.65E-01

0.73

6.67E-02

1.54

1.86E-02

1.70

1.77E-01

1.02 0.94 1.01 1.46 3.41

8.78E-01 5.29E-01 8.66E-01 2.52E-02 2.16E-01

1.01 1.16 0.89 0.83 1.04

8.92E-01 1.75E-01 2.25E-01 8.68E-02 3.83E-01

1.02 1.19 1.15 1.22 0.90

8.87E-01 2.88E-01 2.41E-01 4.39E-02 1.50E-01

1.75

2.16E-03

0.90

1.00E-01

4.34

3.58E-01

1.47 1.23 0.75 0.93 1.01 1.08 0.56 0.45

1.10E-02 4.21E-01 1.54E-03 3.94E-02 7.63E-01 6.14E-01 3.17E-04 5.26E-04

1.44 1.23 1.04 0.91 0.84 0.97 1.16 0.99

1.66E-01 3.24E-01 5.86E-01 1.33E-01 8.63E-02 6.92E-01 2.27E-01 5.95E-01

1.03 0.96 2.29 1.39 1.63 1.19 1.52 2.65

6.72E-01 6.67E-01 8.55E-02 3.28E-01 1.11E-01 2.36E-01 1.36E-01 1.95E-02



lipoprotein ribosomal protein S18 30S ribosomal protein S14 ribosomal protein L33 ribosomal protein L28 CobW/P47K C- domain protein ribosomal protein L31 metallo-beta-lactamase superfamily protein Citrate transporter RNA methyltransferase, TrmH family protein, group 3 cysteinyl-tRNA synthetase 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase transcriptional regulator, CarD family protein LpqE protein DNA repair protein RadA conserved hypothetical protein conserved hypothetical protein carbonic anhydrase base excision DNA repair protein, HhH-GPD family protein AraC-family transcriptional regulator; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00165 hydrolase, alpha/beta hydrolase fold family protein antibiotic biosynthesis monooxygenase domain protein beta-lactamase phosphoglycerate mutase conserved hypothetical protein conserved hypothetical protein negative regulator of genetic competence ClpC/mecB

0.75 1.04 1.00 1.14 0.96 1.06 1.57 1.04 0.56

4.39E-02 7.55E-01 9.91E-01 4.19E-01 6.21E-01 5.76E-01 1.35E-01 6.28E-01 5.88E-03

0.81 1.13 1.07 1.07 1.10 1.17 1.18 1.00 0.96

1.20E-01 1.55E-01 4.84E-01 1.08E-01 3.08E-01 2.37E-01 3.68E-01 9.70E-01 7.90E-01

1.10 1.03 0.92 0.95 1.08 0.94 0.97 0.93 1.03

6.16E-01 2.79E-01 4.22E-01 5.18E-01 3.82E-01 3.28E-01 2.55E-01 4.97E-01 8.52E-01

cysS

0.60 0.60

1.38E-04 2.25E-04

0.81 0.95

3.60E-02 2.47E-01

1.50 1.36

1.61E-02 1.49E-02

ispF

0.22

2.28E-05

1.08

6.95E-01

1.96

5.82E-02

ispD

0.35 0.78 0.39 0.80 1.16 1.26 1.26

7.85E-06 3.27E-02 1.85E-05 1.14E-01 1.84E-02 2.32E-01 1.38E-01

0.83 1.12 0.92 1.25 0.92 1.00 1.12

2.88E-02 2.68E-02 3.25E-01 4.87E-01 3.09E-01 9.69E-01 3.91E-01

1.13 0.58 2.21 1.12 0.70 1.46 1.63

1.26E-01 7.27E-03 2.82E-03 3.17E-01 6.45E-03 1.48E-01 2.69E-04

1.34

5.10E-01

0.69

1.85E-01

1.00

9.52E-01

1.73

5.49E-04

0.87

2.17E-01

0.79

9.33E-02

0.79

3.18E-01

0.99

9.25E-01

1.25

3.46E-01

1.01 0.46 0.33 0.72 1.13

8.53E-01 1.40E-05 2.11E-05 7.39E-03 2.58E-01

0.90 0.95 1.33 1.17 0.86

3.20E-02 6.49E-01 8.17E-02 1.16E-01 1.10E-01

0.97 1.28 0.80 0.90 0.56

3.19E-01 1.66E-01 3.53E-03 6.25E-01 6.08E-03

0.73

4.18E-02

0.95

5.32E-01

1.93

1.43E-03

rpsR rpmG rpmB rpmE

radA


Lsr2 protein hypothetical protein lysS lysyl-tRNA synthetase D-amino acid deaminase Bvg accessory factor family protein panC pantoate--beta-alanine ligase chalcone/stilbene synthase family protein probable conserved transmembrane protein rich in alanine conserved hypothetical protein 2-amino-4-hydroxy-6hydroxymethyldihydropteridine folK pyrophosphokinase folB dihydroneopterin aldolase folP dihydropteroate synthase folE GTP cyclohydrolase I cell division protein epoxide hydrolase limonene 1,2-monooxygenase zinc-binding dehydrogenase LpqG protein hpt hypoxanthine phosphoribosyltransferase tilS tRNA(Ile)-lysidine synthetase conserved hypothetical protein D-alanyl-D-alanine carboxypeptidase/D-alanyl-DdacB alanine-endopeptidase ppa inorganic pyrophosphatase phosphoglycerate dehydrogenase conserved hypothetical protein glucarate dehydratase IclR-family protein transcriptional regulator conserved hypothetical protein peptide transport system ATP-binding protein dipeptide transport ATP-binding protein DppD ABC transporter, membrane spanning protein ABC transporter, membrane spanning protein putative ABC transporter periplasmic oligopeptide-binding protein

1.27 0.99 0.44 0.88 0.43 0.50 0.47

1.21E-01 9.87E-01 4.78E-06 3.03E-01 8.46E-05 7.40E-04 2.19E-04

0.96 0.46 1.01 1.05 0.67 0.69 0.58

5.74E-01 1.51E-02 8.90E-01 6.27E-01 4.41E-04 2.15E-03 3.53E-03

1.25 0.90 1.47 0.98 1.35 0.96 2.95

1.47E-01 3.42E-01 1.19E-02 4.57E-01 1.43E-02 8.56E-01 2.30E-01

1.59 0.43

6.61E-04 1.64E-03

0.81 0.90

3.06E-02 3.28E-01

0.71 1.13

2.88E-02 2.82E-01

0.69 0.63 0.69 0.92 1.08 2.06 1.56 1.04 0.75 1.15 0.59 0.84

9.73E-04 1.75E-03 5.09E-05 9.35E-02 1.53E-01 8.63E-02 5.74E-03 1.54E-01 8.54E-02 7.28E-02 1.33E-03 2.10E-02

0.85 0.88 0.93 0.86 0.89 0.91 0.98 0.87 0.78 0.99 1.05 0.89

1.45E-01 6.75E-02 2.53E-01 1.52E-01 3.73E-01 3.17E-01 6.62E-01 9.64E-03 1.73E-01 7.35E-01 7.13E-01 1.00E-01

1.51 2.10 2.04 2.01 1.06 0.21 0.29 0.57 0.63 0.75 1.57 1.82

3.71E-02 7.15E-02 6.10E-02 1.47E-03 1.98E-01 4.58E-05 6.17E-04 2.36E-03 4.19E-03 6.28E-02 1.70E-01 1.00E-01

0.62 0.34 0.96 0.19 1.02 1.45 0.97 1.75 1.94 3.29 2.73

1.02E-04 3.62E-05 7.52E-01 2.54E-04 8.56E-01 1.26E-01 7.48E-01 1.27E-01 1.22E-01 3.27E-02 2.79E-02

0.89 1.14 10.70 2.65 1.26 1.20 1.02 0.90 0.86 0.83 0.81

4.30E-01 4.00E-01 3.71E-01 3.43E-01 4.35E-01 4.24E-01 8.73E-01 3.36E-01 2.33E-01 2.32E-01 1.15E-02

2.94 0.64 1.03 0.34 1.14 1.03 1.01 1.01 1.07 1.27 1.02

1.50E-01 3.57E-02 8.93E-01 1.01E-03 2.27E-01 6.33E-01 7.12E-01 9.16E-01 5.06E-01 4.97E-01 2.05E-01

2.74

4.08E-02

0.98

7.56E-01

0.93

3.84E-01


transcriptional regulatory protein D-isomer specific 2-hydroxyacid dehydrogenase anti-anti-sigma factor two-component system response regulator conserved hypothetical protein two-component sensor protein magnesium or manganese-dependent protein phosphatase glucarate dehydratase 5-dehydro-4-deoxyglucarate dehydratase NADP-dependent fatty aldehyde dehydrogenase hypothetical protein membrane protein, TerC family protein non-ribosomal peptide synthetase metallopeptidase putative HTH-type transcriptional regulator membrane protein N-acyl-D-glutamate amidohydrolase nucleoside-diphosphate-sugar epimerase conserved hypothetical protein pe family protein hypothetical protein ISMsm3, transposase ISMsm3, transposase conserved hypothetical protein 4-carboxymuconolactone decarboxylase alpha/beta hydrolase fold-1 DNA polymerase III subunit delta adenylate cyclase, family protein 3 topA DNA topoisomerase I conserved hypothetical protein conserved domain protein ATP-dependent rna helicase, dead/deah box family protein conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein

1.07 0.99 0.89 0.93 0.60 1.03

7.82E-01 9.09E-01 3.15E-02 2.01E-01 1.17E-05 7.31E-01

0.86 0.97 1.06 0.82 1.19 0.84

2.56E-01 8.61E-01 4.08E-01 4.89E-02 6.70E-02 5.64E-02

1.24 1.49 1.23 1.23 1.06 1.13

3.43E-01 4.68E-02 1.31E-01 1.56E-01 2.02E-01 5.54E-02

1.21 0.99 1.37 0.94 0.74 1.12 0.60 0.41 4.21 0.76 3.35 0.44 0.82 1.24 1.77 3.29 2.41 1.49 0.98 0.64 0.56 0.68 0.81 0.57 1.64


0.81 1.08 0.95 0.99 2.55 0.85 0.96 1.07 0.90 0.95 0.79 0.82 0.93 1.38 1.23 0.46 0.53 0.88 1.03 1.22 0.94 0.84 0.93 0.83 0.75


1.33 1.16 1.03 1.66 1.35 1.09 3.48 3.11 1.77 0.93 1.01 0.89 1.00 0.61 0.87 1.48 2.13 6.31 0.73 0.69 1.49 1.19 0.68 0.79 0.76


0.70 1.32 1.04 1.81 1.49

1.63E-02 1.07E-01 7.94E-01 1.12E-02 2.88E-01

1.04 0.86 0.95 0.83 1.49

6.63E-01 4.75E-02 5.29E-01 6.53E-03 9.81E-02

1.48 2.51 1.09 1.23 0.85

1.67E-02 2.69E-03 4.17E-01 1.48E-01 2.72E-01

MSMEG_6167 bacterial type II secretion system protein F domain MSMEG_6168 bacterial type II secretion system protein F domain MSMEG_6169 type II/IV secretion system protein MSMEG_6170 hypothetical protein MSMEG_6171 conserved hypothetical protein MSMEG_6172 hypothetical protein MSMEG_6173 morphological differentiation-associated protein MSMEG_6174 transcriptional regulator, IclR family protein MSMEG_6175 2-keto-3-deoxy-galactonokinase MSMEG_6176 2-dehydro-3-deoxy-6-phosphogalactonate MSMEG_6177 galactonate dehydratase MSMEG_6178 D-galactonate transporter MSMEG_6179 acetyl-coenzyme A synthetase MSMEG_6180 secreted protein MSMEG_6181 conserved hypothetical protein MSMEG_6182 conserved hypothetical protein MSMEG_6183 serine protease MSMEG_6184 hydrolase, alpha/beta fold family protein MSMEG_6185 NTP pyrophosphohydrolase MSMEG_6186 conserved hypothetical protein MSMEG_6187 endonuclease III MSMEG_6188 conserved hypothetical protein MSMEG_6189 transcriptional regulator, Crp/Fnr family protein MSMEG_6190 metallo-beta-lactamase family protein MSMEG_6191 translation initiation inhibitor MSMEG_6192 conserved hypothetical protein MSMEG_6193 anion-transporting ATPase MSMEG_6194 beta-lactamase related protein MSMEG_6195 ion-transporting ATPase MSMEG_6196 gaba permease MSMEG_6197 diaminopimelate decarboxylase MSMEG_6198 DNA-binding protein, putative MSMEG_6199 Transcription factor WhiB MSMEG_6200 hypothetical protein MSMEG_6201 Transglycosylase MSMEG_6202 secreted protein

nth

1.23

1.87E-01

1.08

2.88E-01

1.36

4.15E-01

1.21 1.17 0.85 2.17 0.92 1.60 1.21 1.13 1.64 1.86 1.24 1.15 0.98 0.69 1.20 0.85 0.63 0.39 0.56 0.86 1.79 1.02 0.27 0.53 0.60 0.55 0.90 0.51 0.98 0.89 0.55 4.36 1.22 0.98 0.70


1.13 0.96 1.19 1.11 1.01 0.70 0.98 0.89 1.03 1.05 0.86 1.04 0.82 0.88 0.94 0.93 1.06 0.95 1.13 0.99 0.83 0.82 1.05 0.87 0.94 0.98 1.89 0.91 1.32 1.12 1.31 1.12 1.46 0.87 0.93


1.12 1.01 1.17 0.94 1.03 1.45 1.17 1.00 1.06 1.11 0.93 0.34 1.18 1.09 0.81 1.46 1.20 1.66 1.97 0.91 0.94 0.80 1.62 1.00 0.96 1.41 1.22 1.10 1.75 0.96 1.88 0.05 3.07 0.94 1.18


MSMEG_6203 cysteine synthase/cystathionine beta-synthase family protein MSMEG_6205 hypothetical protein MSMEG_6206 serine/threonine protein kinase PksC MSMEG_6207 conserved hypothetical protein MSMEG_6208 palmitoyl-CoA hydrolase MSMEG_6209 conserved hypothetical protein MSMEG_6210 conserved hypothetical protein MSMEG_6211 hypothetical protein MSMEG_6212 hemerythrin HHE cation binding domain subfamily protein, putative MSMEG_6213 Manganese containing catalase MSMEG_6214 GatB/Yqey domain protein MSMEG_6215 conserved hypothetical protein MSMEG_6216 integral membrane protein MSMEG_6217 integral membrane protein MSMEG_6218 secreted protein MSMEG_6219 ATPase family protein associated with various cellular activities (AAA) MSMEG_6220 lipoprotein MSMEG_6221 integral membrane protein MSMEG_6222 integral membrane protein MSMEG_6223 TetR family protein transcriptional repressor LfrR MSMEG_6224 Retinal pigment epithelial membrane protein MSMEG_6225 proton antiporter efflux pump MSMEG_6226 transcriptional regulator, PadR family protein domain protein MSMEG_6227 transcriptional regulator, PadR family protein MSMEG_6228 hypothetical protein glpK MSMEG_6229 glycerol kinase MSMEG_6230 probable acyltransferase MSMEG_6231 conserved hypothetical protein katA MSMEG_6232 catalase KatA MSMEG_6233 conserved hypothetical protein MSMEG_6234 CBS domain pair protein MSMEG_6235 thiopurine S-methyltransferase (tpmt) superfamily protein MSMEG_6236 two-component system, regulatory protein

0.51 11.03 1.14 1.72 0.37 1.41 0.88 1.41

2.78E-03 1.23E-01 5.26E-01 2.77E-03 4.55E-04 2.53E-01 5.42E-01 1.76E-01

1.19 0.23 1.07 0.76 0.95 0.70 1.40 1.99

2.91E-02 6.47E-03 5.22E-01 1.12E-02 6.94E-01 1.48E-02 1.39E-01 2.00E-02

2.09 1.11 2.39 0.85 2.77 33.40 7.52 0.64

1.64E-02 7.62E-01 1.55E-01 9.61E-02 1.43E-01 3.57E-03 3.52E-02 7.04E-02

2.73 1.39 1.32 0.73 1.91 1.20 0.87

1.69E-01 3.35E-01 6.51E-03 1.06E-02 1.21E-02 6.03E-02 2.51E-02

2.92 2.85 1.02 1.10 0.75 0.76 1.07

2.15E-02 4.02E-02 7.31E-01 2.90E-01 1.62E-02 1.45E-02 6.94E-01

0.36 0.44 1.28 13.07 1.57 2.24 3.28

3.63E-04 2.83E-03 4.32E-01 3.78E-01 1.81E-02 1.01E-03 1.09E-03

0.93 0.69 0.64 1.29 0.69 1.47 0.57

4.76E-02 1.30E-02 5.74E-04 4.24E-02 5.69E-03 3.84E-02 1.79E-03

0.81 0.85 0.91 0.87 1.09 1.16 1.30

3.35E-02 1.34E-02 4.53E-01 1.03E-01 6.94E-01 2.09E-01 1.13E-01

1.29 1.57 1.48 0.95 1.51 0.29 1.09

1.77E-02 1.48E-01 4.70E-02 6.67E-01 8.31E-02 1.15E-04 6.62E-01

1.74 1.02 0.45 2.97 0.73 2.28 0.96 1.02 3.40

5.01E-01 8.86E-01 1.25E-04 3.90E-01 6.54E-02 2.31E-04 8.93E-01 8.37E-01 6.95E-04

1.10 0.79 0.99 1.29 1.24 0.84 4.15 1.12 1.10

5.33E-01 1.34E-01 8.82E-01 5.75E-01 3.04E-01 4.01E-01 1.57E-01 3.89E-01 3.94E-01

1.06 4.83 4.42 0.84 1.04 1.02 0.59 0.93 0.34

5.58E-01 1.02E-01 6.12E-02 4.34E-01 2.88E-01 8.00E-01 9.27E-02 6.35E-01 1.27E-05

1.84 2.41

2.04E-02 7.57E-03

0.73 1.05

7.75E-02 7.10E-01

1.25 0.06

1.21E-01 1.36E-07


conserved hypothetical protein putative two-component system sensor kinase 1,3-propanediol dehydrogenase conserved hypothetical protein ATPase associated with various cellular activities, AAA-5 alcohol dehydrogenase, iron-containing response regulator receiver domain protein TetR-family protein transcriptional regulator chloramphenicol resistance protein pyridoxal-phosphate-dependent transferase conserved hypothetical protein conserved hypothetical protein conserved hypothetical protein glutamate--cysteine ligase conserved hypothetical protein conserved hypothetical protein fur family protein transcriptional regulator hypothetical protein conserved hypothetical protein aspartate-semialdehyde dehydrogenase asparate kinase, monofunctional class nitroreductase family protein ammonium transporter glutamine synthetase, type III glutamine amidotransferase, class II FwdC/FmdC family protein glutamate synthase family protein putative oxidoreductase transcriptional regulator thiocyanate hydrolase beta subunit thiocyanate hydrolase gamma subunit putative ScnB protein magnesium transporter hypothetical protein 2-isopropylmalate synthase NAD-glutamate dehydrogenase integral membrane protein

asd amt glnT

mgtE leuA

2.65 3.07 3.50 2.04

1.75E-01 7.66E-03 4.15E-03 2.56E-01

2.03 1.26 1.04 1.91

2.40E-01 9.68E-02 6.55E-01 1.54E-01

0.72 0.05 0.20 0.25

2.44E-01 7.38E-09 4.60E-03 1.61E-02

2.84 2.38 0.65 0.98 1.51 1.14 1.31 1.62 1.49 1.73 0.77 2.85 0.43 2.24 0.37 0.56 0.38 0.62 0.19 0.60 0.60 0.58 0.56 0.79 0.76 1.94 2.05 2.10 0.87 1.00 0.81 1.36 0.80

1.39E-01 4.25E-02 1.70E-02 8.23E-01 1.55E-01 5.91E-02 6.65E-02 2.44E-03 7.29E-04 1.86E-04 4.71E-02 2.66E-03 8.17E-05 5.43E-04 2.46E-04 1.12E-05 3.64E-05 4.95E-04 8.79E-05 6.48E-02 1.41E-01 5.20E-05 5.54E-03 2.25E-01 1.46E-02 1.46E-02 1.86E-02 6.22E-02 4.12E-01 9.90E-01 1.84E-02 1.13E-03 1.20E-01

1.67 2.05 1.32 1.13 4.07 1.89 0.90 0.92 0.87 0.70 0.80 0.80 1.61 0.87 1.01 0.85 0.97 0.97 1.35 1.08 1.10 1.11 0.94 0.92 1.18 1.06 1.19 1.14 0.83 0.68 0.87 0.98 0.96


0.09 0.10 1.16 1.05 1.14 2.48 2.11 1.53 1.37 1.24 2.24 0.43 6.29 2.86 1.62 1.08 1.13 2.04 0.96 1.02 0.96 0.95 1.01 1.02 0.97 0.10 0.14 0.19 0.94 1.15 1.42 1.59 1.06



conserved hypothetical protein DNA polymerase III subunit epsilon mur ligase family protein cobyric acid synthase metallo-beta-lactamase superfamily protein, putative recR recombination protein RecR conserved hypothetical protein N-acetylmuramoyl-L-alanine amidase KanY protein FAD binding domain protein cyclopropane-fatty-acyl-phospholipid synthase DNA polymerase III gamma/tau subunit aspartate transaminase conserved hypothetical protein Trypsin putative DNA-binding protein D-amino-acid dehydrogenase transcription elongation factor GreA transcriptional regulatory protein caib/baif family protein shikimate transporter 5-exo-alcohol dehydrogenase aldehyde dehydrogenase malyl-CoA lyase glyoxylate reductase transcriptional regulator, GntR family protein ligD DNA polymerase LigD, polymerase domain DNA ligase para-nitrobenzyl esterase DNA ligase conserved hypothetical protein gltX glutamyl-tRNA synthetase glutamine-binding periplasmic protein/glutamine transport system permease protein hypothetical protein ABC transporter, ATP-binding protein 4-hydroxybutyrate coenzyme A transferase

0.98 1.25 0.45 0.60

8.73E-01 3.19E-01 4.08E-04 6.16E-04

1.09 1.01 0.78 0.81

4.70E-01 8.98E-01 3.50E-02 5.59E-02

1.06 2.48 1.60 2.30

6.33E-01 1.21E-01 1.77E-02 9.61E-02

2.01 0.66 0.76 1.74 0.55 1.06 0.94 0.47 0.37 0.53 1.16 0.98 4.50 1.09 0.65 0.96 0.98 1.22 1.26 0.98 1.49 1.32 1.61 1.78 1.69 1.00 1.19 0.77


0.75 0.83 0.95 0.78 0.95 0.95 0.81 1.17 0.85 0.90 0.81 0.97 0.80 0.96 0.90 0.88 0.86 0.94 0.91 0.97 0.91 0.87 0.92 0.91 0.89 0.93 1.49 1.25


1.23 1.00 0.92 1.21 1.28 1.18 2.62 0.79 1.99 1.13 1.58 3.06 3.93 2.60 1.02 1.00 0.97 0.62 1.04 0.94 0.98 1.34 1.36 0.95 1.68 1.06 1.06 1.13


1.12 1.07 0.70 0.93

2.40E-02 7.76E-01 1.67E-02 5.54E-01

1.25 1.09 1.25 0.71

2.48E-01 6.80E-01 3.92E-01 5.12E-02

0.89 1.01 0.83 1.44

5.82E-01 7.97E-01 3.67E-01 2.34E-01

MSMEG_6311 MSMEG_6312 MSMEG_6313 MSMEG_6314 MSMEG_6315 MSMEG_6316 MSMEG_6317 MSMEG_6318 MSMEG_6319 MSMEG_6320 MSMEG_6321 MSMEG_6322 MSMEG_6323 MSMEG_6324 MSMEG_6325 MSMEG_6327 MSMEG_6328 MSMEG_6329 MSMEG_6330 MSMEG_6331 MSMEG_6332 MSMEG_6333

lys1 saccharopine dehydrogenase cytochrome P450 107B1 tgt queuine tRNA-ribosyltransferase haloalkane dehalogenase 1 lipoprotein LpqH lipoprotein LpqH lipolytic enzyme, G-D-S-L putative diol dehydratase reactivation protein penicillin-binding protein, transpeptidase diol dehydrase gamma subunit glycerol dehydratase large subunit bifunctional wax ester synthase/acyl-CoA diacylglycerol acyltransferase hypothetical protein peroxidase conserved hypothetical protein cytidine and deoxycytidylate deaminase family protein conserved hypothetical protein conserved hypothetical protein prephenate dehydrogenase ABC transporter, permease protein ProZ amino acid ABC transporter, permease protein amino acid ABC transporter, ATP-binding protein

MSMEG_6334 ABC transporter, quaternary amine uptake transporter (QAT) family protein, substratebinding protein MSMEG_6335 hypothetical protein MSMEG_6336 conserved hypothetical protein MSMEG_6337 Phosphotransferase enzyme family protein MSMEG_6338 phosphoglycerate mutase family protein, putative MSMEG_6339 metallo-beta-lactamase family protein MSMEG_6340 short-chain dehydrogenase/reductase SDR MSMEG_6341 6-phosphogluconate dehydrogenase, NADbinding MSMEG_6342 oxidoreductase MSMEG_6343 conserved hypothetical protein

0.92 2.12 0.58 2.32 0.41 3.53 1.06 1.54 0.64 1.56 1.00

5.02E-01 1.90E-02 3.73E-03 5.16E-02 5.42E-05 2.86E-02 5.95E-01 4.04E-01 6.32E-04 3.20E-01 9.94E-01

0.88 0.64 0.91 1.18 0.77 1.35 1.04 0.97 0.96 0.91 1.13

2.45E-01 3.52E-02 2.82E-01 3.97E-02 1.20E-01 5.92E-02 5.16E-01 5.62E-01 4.13E-01 2.53E-01 2.15E-01

1.07 0.72 1.18 0.69 1.04 0.40 0.46 0.83 0.82 0.63 1.06

4.24E-01 1.07E-01 7.15E-02 7.37E-02 7.89E-01 1.16E-02 3.49E-05 1.14E-01 1.29E-01 1.07E-01 4.91E-01

1.89 24.55 19.76 18.72

3.31E-03 4.42E-02 2.09E-02 3.46E-02

1.16 0.40 0.30 0.29

2.30E-01 9.50E-02 2.66E-02 3.09E-02

0.66 0.89 0.77 1.13

3.39E-01 6.34E-01 2.82E-01 7.29E-01

0.70 1.16 0.89 1.00 2.06 0.85

5.66E-02 4.90E-02 4.60E-02 9.92E-01 1.49E-01 2.68E-02

1.20 0.85 0.82 0.70 1.04 0.96

3.33E-01 4.60E-02 2.84E-02 7.85E-03 6.64E-01 5.79E-01

1.11 0.61 0.49 1.34 0.98 0.95

1.85E-01 9.03E-03 1.74E-04 1.14E-02 7.36E-01 1.54E-01

1.48

2.35E-01

1.40

4.44E-01

1.06

3.69E-01

1.07 1.18 1.24 0.45 0.59 1.52 1.47

6.89E-01 2.26E-01 1.49E-02 2.38E-04 3.44E-03 2.64E-01 2.91E-02

0.98 1.22 0.91 1.05 0.92 1.04 0.89

8.17E-01 3.01E-01 4.32E-01 7.00E-01 1.73E-01 8.03E-01 1.70E-01

1.01 2.11 1.15 1.18 0.92 1.27 1.06

7.78E-01 4.02E-01 2.22E-01 6.08E-01 2.70E-01 2.78E-01 2.35E-01

1.57 1.95 0.88

5.80E-02 5.92E-02 8.71E-02

0.92 0.95 0.92

3.33E-01 4.58E-01 4.37E-01

1.32 0.97 1.44

2.96E-01 3.23E-01 3.27E-02


transcriptional regulator conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hisC histidinol-phosphate aminotransferase conserved hypothetical protein delta3,5-delta2,4-dienoyl-CoA isomerase serine esterase, cutinase family protein hypothetical protein probable transcriptional regulator, AraC family protein, putative hypothetical protein mesocentin trypsin domain protein transcriptional regulator, MarR family protein quinone oxidoreductase cysteine desulfurase family protein conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error conserved hypothetical protein O-antigen export system, ATP-binding protein glycosyl transferase, group 2 family protein DNA-binding protein DNA-binding protein O-antigen export system, permease protein pcaC 4-carboxymuconolactone decarboxylase GntR-family protein regulator membrane protein conserved hypothetical protein panE 2-dehydropantoate 2-reductase transporter, major facilitator family protein transcriptional regulator LacI family protein hypothetical protein senescence marker protein-30 transporter, major facilitator family protein hypothetical protein

1.21 0.26 0.40 1.27 0.67 0.69 0.37 0.50 0.53 0.70

5.84E-02 2.20E-05 4.19E-04 4.10E-01 2.36E-01 3.18E-03 1.03E-04 8.62E-05 1.05E-02 3.06E-01

1.04 1.10 1.15 0.87 1.34 0.94 0.82 0.99 1.97 1.80

6.42E-01 6.16E-01 5.12E-01 2.44E-02 2.81E-01 4.01E-01 1.12E-01 9.01E-01 3.71E-02 1.79E-01

0.98 8.18 3.02 1.15 0.74 1.42 1.70 1.33 0.90 0.65

4.54E-01 5.75E-03 1.54E-01 3.26E-01 1.13E-01 1.64E-02 2.32E-02 1.01E-01 4.15E-01 1.01E-01

1.52 0.97 0.73 0.64 1.14 0.61 0.84

2.55E-02 8.16E-01 1.42E-01 1.76E-02 3.44E-01 3.11E-03 7.21E-02

0.74 1.09 1.01 1.04 1.08 0.91 0.87

1.09E-02 2.34E-01 9.71E-01 2.74E-01 7.19E-01 3.97E-01 1.82E-01

0.63 1.44 1.21 1.27 0.29 1.01 1.80

9.24E-03 1.89E-01 3.12E-01 1.18E-01 3.72E-05 2.37E-01 4.89E-01

0.57 0.70 0.61 0.38 1.86 1.19 0.34 1.03 0.71 0.63 0.69 0.96 1.41 1.32 1.45 1.70 1.41 1.09


1.04 1.01 0.91 0.93 0.91 1.03 1.27 1.06 1.23 0.87 1.06 1.00 1.07 1.22 1.13 0.93 0.87 1.10


1.31 1.19 1.46 2.17 0.56 0.92 2.29 0.98 1.04 2.00 0.80 1.46 0.98 0.94 1.26 0.90 1.26 1.14



conserved hypothetical protein oxidoreductase, FAD-binding transcription regulator FurA katG catalase/peroxidase HPI hypothetical oxidoreductase in MprA 5'region membrane protein probable arabinosyltransferase A probable arabinosyltransferase B probable arabinosyltransferase A transporter, major facilitator family protein propionyl-CoA carboxylase beta chain polyketide synthase acyl-CoA synthase conserved hypothetical protein conserved hypothetical protein antigen 85-C hypothetical protein antigen 85-A antigen 85-C probable conserved transmembrane protein prenyltransferase, UbiA family protein PAP2 superfamily protein bifunctional udp-galactofuranosyl transferase glft glf UDP-galactopyranose mutase Erp protein N-acetylmuramoyl-L-alanine amidase Cof-like hydrolase acyltransferase family protein acyltransferase family protein Rieske 2Fe-2S family protein conserved hypothetical protein conserved hypothetical protein serS seryl-tRNA synthetase conserved hypothetical protein conserved hypothetical protein phosphoglycerate mutase family protein conserved hypothetical protein prephenate dehydratase

0.94 0.59 0.41 0.40 0.36 0.29 0.45 0.48 0.34 0.95 0.30 0.33 0.55 0.71 0.89 0.80 1.05 1.60 1.22 0.56 0.36 0.54 0.49 0.51 2.02 1.10 0.77 0.55 0.78 0.74 0.42 0.45 0.43 0.89 0.46 1.25 1.84 1.39


1.09 1.06 2.43 2.46 0.88 1.10 1.09 1.54 1.50 1.09 0.76 0.76 0.84 0.87 0.91 0.85 0.89 0.64 0.66 1.00 1.04 0.98 0.97 1.29 0.72 1.15 0.92 1.21 0.93 1.01 1.05 0.92 0.99 0.87 1.01 0.90 0.83 1.03


1.18 0.70 0.99 0.08 1.78 1.29 1.60 1.10 1.09 1.31 3.81 3.25 2.51 1.72 2.24 0.34 0.73 1.10 1.40 1.62 2.82 1.77 1.33 1.20 1.34 1.29 1.50 1.48 1.02 1.08 1.20 0.91 1.03 0.88 0.96 1.06 1.17 0.90



conserved hypothetical protein abortive infection protein transcriptional regulator ferritin family protein Glycerophosphoryl diester phosphodiesterase family protein probable conserved transmembrane protein rhodanese-like domain protein conserved hypothetical protein [Mn] superoxide dismutase conserved hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein conserved hypothetical protein hypothetical protein conserved hypothetical protein hypothetical protein copper resistance protein CopC copper resistance protein D hypothetical protein regulator of ribonuclease activity A monooxygenase, flavin-binding family protein transcriptional regulator, TetR family protein integral membrane protein dinP DNA polymerase IV YiaAB two helix domain protein PHP domain protein hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein hypothetical protein transcriptional regulator, ArsR family protein [NADP+] succinate-semialdehyde dehydrogenase sulfate permease conserved hypothetical protein conserved hypothetical protein

0.66 0.62 0.78 0.95

2.92E-02 2.10E-02 7.63E-02 6.19E-01

0.97 0.93 0.88 1.06

8.04E-01 2.01E-01 1.56E-01 7.48E-01

1.16 1.35 1.12 14.24

4.28E-01 3.97E-01 3.95E-01 1.53E-01

1.17 1.20 1.14 3.64 0.94 2.96 1.09 0.92 1.92 1.00 1.32 0.67 0.63 0.59 0.74 0.94 0.46 1.83 1.75 1.21 2.35 1.05 1.87 0.81 0.93 0.65 0.49 0.44 0.57 1.10 1.12 1.14 0.90


0.77 0.92 0.88 0.97 1.17 0.77 2.19 1.17 0.53 0.91 1.03 0.82 0.92 1.04 0.96 0.77 0.84 0.52 0.73 1.09 1.00 1.17 0.99 1.10 1.26 1.19 1.51 1.07 1.03 1.05 0.63 0.88 1.47


0.68 0.99 1.07 0.05 0.71 0.93 1.55 0.98 0.49 1.18 2.17 3.60 1.04 0.98 1.16 0.90 1.28 4.05 5.54 1.00 1.41 1.69 1.04 0.88 0.53 0.86 0.65 0.94 1.60 0.38 1.21 0.32 1.23


MSMEG_6456 conserved hypothetical protein MSMEG_6457 oxidoreductase molybdopterin binding domain, putative MSMEG_6458 glutamate synthase, small subunit MSMEG_6459 ferredoxin-dependent glutamate synthase 1 MSMEG_6460 hypothetical protein MSMEG_6461 hypothetical protein MSMEG_6464 conserved hypothetical protein MSMEG_6465 chloride channel MSMEG_6466 aquaporin Z MSMEG_6467 starvation-induced DNA protecting protein MSMEG_6468 conserved hypothetical protein MSMEG_6469 conserved hypothetical protein MSMEG_6470 hypothetical protein MSMEG_6471 glycine/D-amino acid oxidase MSMEG_6472 hypothetical protein MSMEG_6473 tetracenomycin polyketide synthesis Omethyltransferase TcmP MSMEG_6474 nucleoside-diphosphate-sugar epimerase MSMEG_6475 conserved hypothetical protein MSMEG_6476 conserved hypothetical protein MSMEG_6477 methionine-S-sulfoxide reductase MSMEG_6478 putative cytochrome P450 135B1 MSMEG_6479 putative transcriptional regulator MSMEG_6480 putative transcriptional regulatory protein MSMEG_6481 conserved hypothetical protein MSMEG_6482 secreted protein MSMEG_6483 methyltransferase type 11 MSMEG_6484 glycosyl transferase MSMEG_6485 ATP binding protein MSMEG_6486 oxidoreductase, FAD/FMN-binding MSMEG_6487 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2, 4dienoate decarboxylase MSMEG_6488 conserved hypothetical protein MSMEG_6489 2,6-dihydroxypyridine hydroxylase MSMEG_6490 major facilitator superfamily protein MSMEG_6491 aldehyde dehydrogenase MSMEG_6492 GAF domain protein, putative

msrA

1.22

3.40E-02

1.40

2.27E-01

2.67

1.04E-01

1.36 0.36 0.37 0.70 1.06 0.67 1.25 1.62 1.86 0.99 11.53 1.12 0.73 7.59

3.20E-04 2.16E-04 9.06E-05 1.15E-02 5.63E-01 1.43E-01 2.24E-01 9.61E-02 3.52E-01 9.49E-01 9.13E-04 3.33E-01 2.56E-01 4.97E-02

1.12 0.83 0.80 1.13 1.04 1.76 1.01 0.90 3.13 1.68 0.79 2.01 0.83 4.08

3.96E-02 1.41E-01 9.01E-02 1.01E-01 5.67E-01 3.44E-01 8.09E-01 8.05E-03 1.14E-02 9.46E-02 1.04E-01 1.21E-01 1.73E-03 3.47E-02

0.74 21.40 0.84 0.79 1.18 1.26 1.16 0.80 0.23 1.20 0.61 1.11 0.76 1.14

1.33E-02 3.74E-01 1.78E-01 3.99E-01 2.25E-01 1.45E-01 1.76E-01 1.19E-01 1.01E-05 4.28E-01 8.60E-02 5.04E-01 5.83E-02 4.92E-02

0.98 0.91 0.98 1.01 1.97 1.25 1.53 1.01 0.42 0.81 0.51 0.72 0.58 0.59

8.48E-01 6.61E-01 8.50E-01 9.04E-01 3.12E-03 3.42E-01 2.51E-01 8.35E-01 4.06E-05 4.39E-03 3.98E-05 5.88E-03 3.20E-04 3.75E-03

1.41 1.01 1.05 0.88 0.74 0.94 0.86 0.98 0.94 1.11 0.91 1.03 1.07 0.95

3.17E-02 9.07E-01 1.97E-01 1.51E-01 1.77E-02 6.27E-01 2.40E-01 6.46E-01 2.58E-01 2.65E-01 1.03E-01 5.68E-01 1.31E-02 5.58E-01

1.10 3.11 0.64 1.07 0.90 7.02 0.98 1.05 1.09 0.90 0.70 1.32 1.64 0.98

6.72E-01 3.63E-01 3.71E-02 6.97E-01 1.35E-01 5.33E-02 8.89E-01 3.46E-01 6.46E-01 3.06E-01 4.61E-02 1.91E-01 8.35E-03 9.42E-01

1.00 0.60 1.47 1.68 1.03 0.92

9.95E-01 7.94E-03 1.59E-01 1.93E-02 8.30E-01 4.67E-01

1.02 0.96 1.16 1.19 1.34 1.40

8.79E-01 7.00E-01 5.54E-01 1.16E-01 2.81E-02 2.29E-01

1.02 0.87 1.01 0.98 1.04 0.80

8.75E-01 3.00E-01 8.60E-01 3.27E-01 4.00E-01 1.50E-01

MSMEG_6493 hypothetical protein MSMEG_6494 ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit, putative MSMEG_6495 ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit, putative MSMEG_6496 nitrate/sulfonate/bicarbonate ABC transporter ATPase subunit MSMEG_6497 hypothetical protein MSMEG_6498 hypothetical protein MSMEG_6499 conserved hypothetical protein MSMEG_6500 conserved hypothetical protein MSMEG_6501 hypothetical protein MSMEG_6502 conserved hypothetical protein MSMEG_6503 transcriptional regulator, TetR family protein MSMEG_6504 conserved hypothetical protein MSMEG_6505 NfnB protein MSMEG_6506 nicotinamidase/pyrazinamidase glgX MSMEG_6507 glycogen debranching enzyme GlgX MSMEG_6508 MarR-family protein transcriptional regulator MSMEG_6509 ABC-type drug export system, ATP-binding protein MSMEG_6510 ABC-type drug export system, membrane protein MSMEG_6511 acyl-CoA dehydrogenase domain protein MSMEG_6512 acyl-CoA dehydrogenase domain protein MSMEG_6513 membrane transport protein MSMEG_6514 trehalose synthase-fused probable maltokinase treS MSMEG_6515 trehalose synthase MSMEG_6516 hypothetical protein MSMEG_6517 hypothetical protein MSMEG_6518 conserved hypothetical protein MSMEG_6519 pyridoxamine 5'-phosphate oxidase family MSMEG_6520 orotate phosphoribosyltransferase MSMEG_6521 sulfate/thiosulfate import ATP-binding protein CysA 2 MSMEG_6522 ABC transporter, inner membrane subunit MSMEG_6523 ABC transporter, membrane spanning protein MSMEG_6524 ABC Polyamine/Opine/Phosphonate transporter, periplasmic ligand binding protein

0.97

5.46E-01

1.07

6.12E-01

1.12

2.47E-01

1.44

2.80E-01

1.12

3.70E-01

0.99

9.32E-01

1.39

9.59E-02

0.95

6.92E-01

1.22

3.76E-01

1.48 0.74 2.07 2.90 1.22 1.13 0.34 1.47 0.31 0.96 1.29 0.79 0.85

1.04E-01 9.76E-03 1.54E-02 3.09E-03 2.48E-01 2.06E-01 4.12E-04 4.61E-01 1.40E-05 5.23E-01 8.55E-04 2.42E-02 1.83E-01

0.97 0.91 2.23 1.06 1.39 1.36 1.02 1.32 1.19 1.11 0.82 0.97 0.79

8.14E-01 5.45E-01 8.69E-02 1.86E-01 2.55E-01 1.12E-01 8.89E-01 5.18E-02 2.51E-01 2.29E-01 3.55E-02 6.95E-01 8.34E-02

1.07 1.47 2.27 0.36 0.46 0.82 1.92 0.87 1.05 1.01 0.87 1.21 3.32

5.69E-01 3.15E-01 2.13E-01 1.08E-05 1.62E-03 2.98E-01 6.10E-02 1.53E-01 1.75E-02 7.14E-01 5.13E-01 4.67E-02 1.02E-01

0.92 0.91 1.02 1.05 0.72 0.95 0.76 0.90 1.16 1.22 0.58 0.96

1.64E-01 6.12E-01 8.38E-01 5.40E-01 2.98E-01 4.50E-01 1.59E-02 4.82E-01 1.72E-01 6.64E-02 4.91E-04 5.37E-01

1.01 0.92 0.96 1.02 1.29 0.94 1.24 0.59 1.04 0.85 1.07 0.70

8.94E-01 3.67E-01 6.85E-01 8.99E-01 4.85E-02 5.34E-01 1.30E-01 8.76E-04 7.53E-01 2.54E-01 7.08E-01 1.99E-02

3.71 2.93 4.04 4.27 1.18 0.88 0.79 0.99 1.08 0.57 1.04 0.95

1.30E-02 2.73E-02 2.18E-03 1.66E-02 4.87E-02 2.56E-01 4.73E-02 6.38E-01 2.19E-01 2.36E-02 6.50E-01 5.55E-01

0.80 0.54 0.64

5.89E-02 1.09E-06 2.65E-02

1.02 1.17 1.05

7.72E-01 9.05E-02 6.01E-01

0.55 0.70 0.59

2.18E-02 7.47E-02 2.35E-02

0.85

5.95E-02

1.14

1.79E-01

0.22

1.83E-05

MSMEG_6525 MSMEG_6526 MSMEG_6527 MSMEG_6528 MSMEG_6529 MSMEG_6530 MSMEG_6531 MSMEG_6532 MSMEG_6533 MSMEG_6534 MSMEG_6535 MSMEG_6536 MSMEG_6537 MSMEG_6538 MSMEG_6539 MSMEG_6540 MSMEG_6541 MSMEG_6542 MSMEG_6543

MSMEG_6543


hypothetical protein pyridoxamine 5'-phosphate oxidase family transcriptional regulator, TetR family protein conserved hypothetical protein conserved hypothetical protein cytochrome c oxidase subunit III family protein conserved hypothetical protein transcriptional regulatory protein conserved hypothetical protein hypothetical protein translation elongation factor EF-G carboxymuconolactone decarboxylase transcriptional regulator, TetR family protein 3-oxoacyl-(acyl-carrier-protein) reductase, conserved hypothetical protein virulence factor Mce family protein anti-sigma factor antagonist B12 binding domain protein GAF domain protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01590 GAF domain protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF01590 transport-associated, putative phosphoglycerate mutase family protein transcriptional regulatory protein amidohydrolase 2 Rieske iron-sulfur protein conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein conserved hypothetical protein ABC transporter ATP-binding protein

1.08 1.53 1.18 1.09 1.45 2.31 0.68 2.06 1.19 1.19 25.45 0.75 0.81 0.49 0.68 0.51 0.82 0.90


0.87 0.87 1.14 0.99 0.98 1.03 1.63 0.81 1.03 1.22 1.26 1.15 1.17 0.95 0.95 0.89 1.40 1.21


0.71 1.07 1.05 0.95 0.91 0.96 1.95 1.23 1.16 3.24 0.08 1.03 1.14 0.98 1.44 3.82 0.76 1.24


0.67

5.21E-03

1.13

3.68E-02

3.35

8.57E-02

0.92 0.95 1.11 0.86 1.82 1.39 1.52 1.34 3.88 1.68 1.19 0.56

1.20E-01 4.24E-01 5.25E-01 1.49E-01 3.10E-02 7.64E-02 1.59E-01 1.49E-01 1.97E-01 1.56E-01 2.08E-01 2.61E-03

1.01 0.74 1.39 1.11 0.91 1.01 1.37 1.46 1.24 1.14 1.14 1.25

8.86E-01 8.42E-03 3.53E-02 4.00E-01 5.59E-01 9.15E-01 1.16E-01 9.03E-02 2.40E-01 2.05E-01 2.01E-01 1.90E-01

6.51 1.63 1.29 1.13 1.07 0.96 0.99 0.75 1.01 1.18 1.16 0.64

1.97E-01 6.33E-02 1.49E-01 8.21E-02 6.10E-01 3.37E-01 8.05E-01 5.65E-02 7.39E-01 6.61E-01 3.29E-01 1.05E-01

MSMEG_6554 hypothetical ABC transporter ATP-binding protein MSMEG_6555 transcriptional regulator, TetR family protein, putative MSMEG_6556 putative transcriptional regulator MSMEG_6557 dehydrogenase MSMEG_6558 putative enoyl-CoA hydratase MSMEG_6559 hypothetical protein MSMEG_6560 acyl dehydratase MSMEG_6561 nonspecific lipid-transfer protein MSMEG_6562 putative acyl-CoA dehydrogenase MSMEG_6563 dihydrokaempferol 4-reductase MSMEG_6564 transcriptional regulator, TetR family protein MSMEG_6565 conserved hypothetical protein MSMEG_6566 hypothetical protein MSMEG_6567 iron-dependent peroxidase MSMEG_6568 regulatory protein, LuxR, putative MSMEG_6569 conserved hypothetical protein MSMEG_6570 integral membrane protein MSMEG_6571 conserved hypothetical protein MSMEG_6572 methyltransferase MSMEG_6573 conserved hypothetical protein MSMEG_6574 conserved hypothetical protein MSMEG_6575 beta-lactamase MSMEG_6576 pyridoxamine 5'-phosphate oxidase family MSMEG_6577 methylmalonyl-CoA carboxyltransferase 12S subunit MSMEG_6578 hypothetical protein MSMEG_6579 conserved hypothetical protein MSMEG_6580 transcriptional regulator family protein MSMEG_6581 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_6582 pyridine nucleotide-disulphide oxidoreductase domain protein MSMEG_6583 antigen 85-C MSMEG_6584 acyl-CoA dehydrogenase MSMEG_6585 acyl-CoA dehydrogenase MSMEG_6586 alpha/beta hydrolase, putative

0.70

1.24E-01

1.53

2.24E-02

1.01

3.80E-01

0.68 1.04 0.28 1.32 2.01 0.83 0.89 0.98 0.93 0.70 0.68 2.49 0.88 1.00 1.23 1.31 0.97 0.93 2.35 0.74 0.74 3.85


1.52 1.01 1.40 1.00 0.73 1.15 1.46 1.81 2.49 1.00 1.99 4.41 2.23 1.14 1.46 1.63 1.17 1.84 1.08 1.07 0.98 1.66


0.80 1.47 7.35 1.36 2.81 1.16 1.00 0.96 1.30 1.17 0.90 4.63 1.16 1.03 1.01 1.33 1.62 1.00 1.09 1.65 1.48 0.79


1.01 1.07 2.45 1.29

9.32E-01 2.63E-01 6.44E-02 5.39E-02

0.99 1.29 1.25 0.83

7.10E-01 3.46E-01 4.58E-02 4.28E-03

2.02 0.99 0.38 5.81

1.53E-01 6.00E-01 2.24E-02 3.56E-01

0.90

1.33E-01

1.17

1.95E-01

0.73

3.74E-03

1.20 1.06 1.28 1.34 1.02

4.28E-01 8.63E-01 7.80E-02 1.57E-02 5.08E-01

0.97 0.82 0.85 0.88 1.22

6.11E-01 3.74E-01 2.06E-02 3.23E-02 1.33E-01

1.01 1.12 0.49 0.24 1.05

8.44E-01 7.59E-01 9.28E-03 2.96E-04 5.40E-01


hrpA ATP-dependent helicase HrpA fumarylacetoacetate conserved hypothetical protein aminotransferase, class V family protein short-chain dehydrogenase/reductase SDR ATP-binding protein amino acid ABC transporter, permease protein, 3TM region, His/Glu/Gln/Arg/opine secreted protein conserved hypothetical protein hydrolase of the alpha/beta superfamily protein 6,7-dimethyl-8-ribityllumazine synthase regulatory protein, LuxR; this gene contains a frame shift which is not the result of sequencing error regulatory protein, LuxR; this gene contains a frame shift which is not the result of sequencing error transposase hypothetical protein oxidoreductase NADH:flavin oxidoreductase/nadh oxidase transcriptional regulator, TetR family protein transcriptional regulatory protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein protein of unknown function DUF58, putative hypothetical protein moxR ATPase, MoxR family protein conserved hypothetical protein integral membrane protein hypothetical protein S-(hydroxymethyl)glutathione dehydrogenase nudix hydrolase

1.56 0.71 1.29 0.47 0.72 0.82

5.37E-01 1.06E-01 5.28E-02 2.39E-05 2.06E-02 4.21E-02

1.02 0.96 0.97 1.02 0.91 0.87

9.02E-01 7.65E-01 9.20E-02 7.39E-01 2.05E-01 2.33E-01

1.54 0.96 1.00 0.98 1.91 0.68

3.10E-01 8.51E-02 9.70E-01 9.25E-01 2.16E-02 2.50E-02

0.83 1.08 0.39 0.75 0.52

1.69E-02 5.61E-01 4.80E-05 1.20E-02 4.26E-04

0.72 0.80 0.77 0.98 1.12

6.14E-02 1.09E-02 1.47E-02 7.85E-01 3.86E-01

0.52 0.40 0.67 1.40 1.08

1.66E-02 1.14E-03 5.78E-02 4.78E-01 3.58E-01

2.72

1.09E-01

1.16

6.23E-02

1.26

2.88E-01

1.24 1.56 0.87 0.93 0.80 0.85 0.90 1.14 0.92 0.91 0.77 1.82 1.84 1.11 1.58 1.08 3.04 1.99 1.09


0.98 0.94 0.87 1.00 0.82 0.94 0.86 1.11 1.36 1.39 1.26 1.40 0.98 1.45 1.13 1.00 1.97 2.51 1.10


1.01 1.27 1.25 2.44 1.05 1.10 1.73 1.03 0.95 1.06 1.06 1.45 0.90 0.73 1.55 1.18 0.51 0.42 1.42


MSMEG_6618 DEAD/DEAH box helicase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851 MSMEG_6619 conserved hypothetical protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_6620 conserved hypothetical protein MSMEG_6621 bacterial luciferase family protein MSMEG_6622 cytochrome P450 monooxygenase MSMEG_6623 dehydrogenase MSMEG_6624 conserved hypothetical protein MSMEG_6625 glyoxalase family protein MSMEG_6626 short-chain dehydrogenase/reductase SDR MSMEG_6627 nitroreductase family protein MSMEG_6628 transcriptional regulator, TetR family protein MSMEG_6629 malonate decarboxylase, epsilon subunit MSMEG_6630 glyoxalase family protein MSMEG_6631 phosphoribosyl-dephospho-CoA transferase MSMEG_6632 beta subunit of malonate decarboxylase MSMEG_6633 malonate decarboxylase acyl carrier protein MSMEG_6634 triphosphoribosyl-dephospho-CoA synthase MdcB MSMEG_6635 alpha subunit of malonate decarboxylase MSMEG_6636 [Mn] superoxide dismutase MSMEG_6637 hypothetical protein MSMEG_6638 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase MSMEG_6639 transcriptional regulator, GntR family protein, putative MSMEG_6640 hypothetical protein MSMEG_6641 nitrilotriacetate monooxygenase component A MSMEG_6642 caib/baif family protein MSMEG_6643 DNA-binding protein MSMEG_6644 malyl-CoA lyase MSMEG_6645 2-methylcitrate dehydratase 2

0.65

3.03E-04

0.98

7.46E-01

1.81

1.56E-01

0.47 0.69 1.07 1.47 1.13 1.44 1.24 1.13 2.24 1.27 0.76 1.19 0.87 0.60 0.83


0.98 0.84 1.18 1.17 0.98 0.97 1.05 0.87 0.72 0.77 1.07 0.90 1.55 1.38 1.04


2.12 2.14 1.00 1.08 1.15 0.96 1.07 1.60 0.86 0.80 1.16 0.87 1.28 1.12 2.38


mdcB

0.78 0.40 0.70 1.66

5.91E-02 1.19E-04 3.37E-02 5.23E-02

1.09 1.03 0.79 0.57

4.13E-01 7.31E-01 1.57E-01 1.75E-02

0.88 1.18 0.38 1.10

1.59E-01 4.15E-01 2.69E-05 7.13E-01

metE

0.41

4.83E-05

1.61

3.78E-01

0.61

1.77E-01

0.64 0.95 0.84 0.89 0.98 1.02 0.99

3.24E-04 5.52E-01 9.82E-02 6.26E-02 8.43E-01 8.55E-01 8.09E-01

0.87 0.96 0.70 0.97 1.07 1.11 1.05

4.32E-02 3.57E-01 3.93E-02 8.08E-01 4.18E-01 6.93E-01 6.68E-01

0.69 0.85 0.94 0.92 1.26 0.93 1.05

3.24E-02 3.33E-01 3.94E-01 2.73E-01 2.27E-01 6.05E-01 7.33E-01

mdcH mdcG mdcC


methylisocitrate lyase citrate synthase 2 pyruvate carboxylase conserved hypothetical protein hypothetical protein hypothetical protein hypothetical protein hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative hypothetical protein; this gene contains a frame shift which is not the result of sequencing error; identified by Glimmer2; putative TnpC protein conserved hypothetical protein conserved hypothetical protein alpha subunit of malonate decarboxylase alpha/beta hydrolase fold hypothetical protein permease, cytosine/purines, uracil, thiamine, allantoin family protein O-methyltransferase, putative short chain dehydrogenase C5-O-methyltransferase methylenetetrahydrofolate reductase family protein, putative integral membrane protein conserved hypothetical protein conserved hypothetical protein ABC transporter, periplasmic substrate-binding protein, putative ABC transporter, permease protein ABC transporter, permease protein, putative sulfate/thiosulfate import ATP-binding protein CysA type I phosphodiesterase 6-aminohexanoate-cyclic-dimer hydrolase transcriptional regulator, LysR family protein

prpB pyc

0.85 1.28 1.10 0.26 1.42 1.03 1.17

3.30E-01 5.17E-01 6.65E-01 2.26E-05 6.85E-02 8.30E-01 4.73E-02

1.22 1.19 1.43 1.18 0.99 0.94 1.17

9.45E-02 8.56E-02 7.19E-02 2.82E-01 9.34E-01 5.96E-01 5.41E-01

0.95 1.00 1.01 0.90 1.08 1.06 0.96

1.84E-01 4.72E-01 8.52E-01 7.36E-01 5.08E-01 8.47E-01 3.47E-01

1.70

9.77E-02

1.69

2.70E-01

1.10

3.04E-01

0.91 1.07 1.14 1.44 1.09 0.99 1.02

5.67E-01 6.26E-01 6.49E-01 2.82E-01 4.17E-01 9.56E-01 8.74E-01

0.87 1.35 1.34 1.26 1.05 1.72 1.02

3.43E-01 1.31E-01 1.63E-01 1.67E-01 3.74E-01 5.25E-02 3.01E-01

0.93 2.12 3.90 1.25 1.45 0.93 1.28

4.83E-01 1.68E-01 2.51E-01 4.44E-01 3.48E-01 5.03E-01 2.84E-01

0.68 0.78 1.93 1.65

2.69E-01 2.18E-03 3.41E-03 1.31E-01

0.91 0.94 1.14 1.22

4.29E-01 2.24E-01 1.00E-01 1.58E-01

0.87 1.72 1.17 1.52

2.30E-01 3.81E-02 1.85E-01 1.37E-01

1.43 1.21 0.96 1.01

2.94E-01 4.69E-01 8.44E-01 9.51E-01

1.28 1.52 1.04 1.52

1.70E-01 1.48E-01 3.67E-01 5.70E-03

1.14 0.67 0.85 1.05

2.38E-01 9.20E-02 1.92E-01 4.45E-01

1.18 1.22 1.05

6.07E-01 4.05E-01 6.95E-01

0.93 1.12 1.51

3.40E-01 1.73E-01 3.03E-01

0.91 1.00 1.06

3.83E-01 6.69E-01 5.68E-01

1.35 1.05 0.73 1.57

1.24E-01 3.49E-01 8.41E-02 3.49E-01

1.04 1.20 0.99 1.22

5.39E-01 1.75E-01 7.88E-01 3.34E-01

1.01 0.97 0.97 0.84

9.05E-01 5.66E-01 6.51E-01 1.28E-01


hypothetical protein probable conserved transmembrane protein transcriptional regulator, LysR family protein conserved hypothetical protein metallo-beta-lactamase family protein integral membrane protein hypothetical protein RNA polymerase sigma-70 factor, putative probable peroxiredoxin, putative agarase gabT 4-aminobutyrate transaminase glutaryl-CoA dehydrogenase aldehyde dehydrogenase, thermostable regulatory protein CAIB/BAIF family protein glutamine amidotransferase class-I glutamine amidotransferase putative glutamine-binding periplasmic protein glutamine synthetase III conserved domain protein cytochrome P450 hypothetical protein conserved hypothetical protein regulatory protein amino acid permease [NADP+] succinate-semialdehyde dehydrogenase N5,N10- methylenetetrahydromethanopterin reductase-related protein shikimate 5-dehydrogenase regulatory protein hypothetical protein hypothetical protein epoxide hydrolase cyclopentanol dehydrogenase hydrolase, alpha/beta fold family protein 4-hydroxybenzoate transporter maleylacetate reductase hydroxyquinol 1,2-dioxygenase

1.00 1.27 5.20 1.18 1.09 1.34 1.58 1.50 1.15 1.05 0.79 0.62 0.83 1.20 0.74 1.00 1.15 3.08 3.54 2.31 4.85 0.72 0.74 0.95 3.13 3.33


1.96 1.07 1.27 0.91 1.00 0.76 0.84 1.31 1.15 1.33 0.98 0.95 0.93 1.05 0.95 0.91 0.99 0.79 0.71 0.78 0.67 0.72 0.94 0.89 0.71 0.88


1.02 1.54 1.03 0.33 1.04 0.88 1.04 0.98 0.98 0.98 0.39 0.50 0.52 1.67 0.73 1.57 1.08 0.89 0.60 0.88 1.05 3.21 0.94 1.18 0.96 1.05


1.74 3.62 2.10 1.78 0.95 1.23 2.15 1.20 1.26 1.39 1.01

6.85E-02 3.20E-01 3.12E-02 4.21E-01 7.67E-01 1.60E-01 1.02E-01 2.86E-02 1.27E-01 1.65E-01 8.13E-01

1.93 1.12 1.19 1.35 1.14 1.23 1.34 1.33 0.93 1.31 1.22

8.28E-02 2.57E-01 2.18E-01 1.60E-01 1.11E-01 3.31E-01 1.42E-01 9.46E-02 4.47E-01 4.51E-02 2.53E-01

0.99 1.29 1.24 1.17 1.61 1.01 0.87 0.85 0.92 0.94 1.48

7.82E-01 2.14E-01 4.13E-01 2.69E-01 1.95E-01 8.96E-01 1.91E-01 2.06E-01 3.91E-01 3.44E-01 3.41E-01


conserved hypothetical protein AP endonuclease, family protein 2 AP endonuclease, family protein 2 oxidoreductase, Gfo/Idh/MocA family protein transporter, major facilitator family protein epoxide hydrolase epoxide hydrolase hypothetical protein conserved hypothetical protein conserved hypothetical protein ABC-type cobalt transport system ABC transporter, ATP-binding protein ABC transporter, permease protein amino acid permease-associated region conserved hypothetical protein DNA-binding protein putative oxidoreductase YdbC transcriptional regulatory protein integral membrane protein hydrolase, carbon-nitrogen family protein dibenzothiophene desulfurization enzyme A amino acid permease, putative LacI-family protein transcriptional regulator putative membrane protein probable transcriptional regulator YdhC hypothetical protein 1-aminocyclopropane-1-carboxylate deaminase antar domain protein conserved hypothetical protein lactoylglutathione lyase oxidoreductase FAD/NAD transcriptional regulator, GntR family protein oxidoreductase, aldo/keto reductase family oxidoreductase ATPase component of ABC transporters with duplicated ATPase domains MSMEG_6749 conserved hypothetical protein MSMEG_6750 hypothetical protein

1.41 2.33 1.86 1.88 2.19 1.24 1.48 1.49 1.89 0.54 0.40 0.54 0.60 1.13 0.79 1.28 0.86 0.96 1.05 0.59 0.21 0.30 0.92 1.19 0.78 1.99 0.80 0.60 1.01 0.41 0.69 0.62 0.91 3.95


1.16 1.32 1.07 1.15 0.83 1.15 1.04 0.99 0.73 1.06 1.03 0.95 0.70 1.74 1.48 0.96 0.89 0.87 1.32 0.79 0.98 1.04 1.10 0.89 1.18 0.73 0.94 0.95 1.14 0.96 1.10 0.92 0.76 1.45


1.14 1.12 1.06 1.01 0.76 0.99 1.03 1.11 0.58 1.21 1.50 1.52 1.29 0.72 0.85 0.89 1.22 0.71 1.10 1.15 0.76 0.92 0.94 1.22 1.19 1.10 0.56 1.50 1.68 0.98 1.12 0.84 0.80 0.81


0.78 0.50 0.49

6.44E-02 1.23E-04 2.92E-03

0.95 1.08 1.03

5.13E-01 4.56E-01 8.12E-01

1.90 1.39 1.22

1.02E-02 2.42E-01 1.49E-01

MSMEG_6751 hypothetical protein MSMEG_6752 endoglucanase A MSMEG_6753 oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_6754 MaoC like domain protein MSMEG_6755 isoflavone reductase glpK MSMEG_6756 glycerol kinase MSMEG_6757 glycerol operon regulatory protein MSMEG_6758 transport integral membrane protein glpK MSMEG_6759 glycerol kinase MSMEG_6760 conserved hypothetical protein MSMEG_6761 glycerol-3-phosphate dehydrogenase 2 MSMEG_6762 transcriptional regulator MSMEG_6763 oxidoreductase MSMEG_6764 transcriptional regulator, TetR family protein MSMEG_6765 ABC-2 type transporter superfamily protein MSMEG_6766 ABC transporter, ATP-binding protein, NodI family protein MSMEG_6767 mycocerosic acid synthase MSMEG_6768 halogenase MSMEG_6769 transporter, monovalent cation:proton antiporter-2 (CPA2) family protein MSMEG_6770 conserved hypothetical protein MSMEG_6771 conserved hypothetical protein MSMEG_6772 homoserine O-acetyltransferase MSMEG_6773 CaiB/BaiF family protein MSMEG_6774 enoyl-CoA hydratase MSMEG_6775 major facilitator superfamily protein transporter MSMEG_6776 transcriptional regulator, LysR family protein MSMEG_6777 probable enoyl-CoA hydratase MSMEG_6778 hypothetical protein MSMEG_6779 conserved hypothetical protein, putative MSMEG_6780 phenazine biosynthesis protein PhzF MSMEG_6781 hypothetical protein MSMEG_6782 hypothetical protein MSMEG_6783 integral membrane protein MSMEG_6784 beta-lactamase tpiA MSMEG_6785 triosephosphate isomerase

1.87 0.42

1.32E-01 4.32E-05

1.56 0.87

8.70E-02 2.70E-01

0.93 0.82

4.45E-01 1.99E-01

3.03 0.48 2.42 0.84 2.27 2.18 2.25 0.81 1.92 0.79 1.25 0.94 1.18

3.58E-02 5.24E-04 6.89E-03 2.43E-02 1.94E-03 2.84E-03 2.93E-02 1.74E-01 4.05E-03 1.15E-01 5.91E-02 9.03E-02 3.82E-01

1.00 1.04 1.10 1.12 0.84 0.71 0.99 0.90 0.86 0.87 1.06 2.03 1.24

9.78E-01 8.57E-01 6.93E-01 2.66E-01 1.85E-01 2.09E-02 9.14E-01 6.76E-01 4.34E-04 1.14E-01 4.63E-01 1.00E-01 4.59E-01

0.64 0.78 0.55 1.50 0.55 0.24 0.35 1.02 0.23 6.07 1.71 1.26 1.12

8.97E-02 1.95E-01 1.43E-02 9.44E-02 2.18E-03 1.92E-03 1.13E-02 7.69E-01 3.34E-03 1.03E-01 1.80E-01 3.29E-01 3.32E-01

0.69 1.02 0.89

1.60E-02 7.15E-01 5.19E-01

1.29 1.39 1.79

7.41E-02 1.21E-01 6.31E-02

1.13 0.75 0.97

2.05E-01 9.73E-02 9.05E-01

0.81 1.65 1.13 4.29 2.29 2.44 5.95 4.36 2.54 2.08 1.82 1.50 1.36 1.15 0.82 1.05 1.04


1.10 1.82 1.67 0.63 0.54 0.94 0.73 0.80 0.67 0.59 1.02 0.90 1.20 1.27 0.96 1.05 1.55


1.04 0.90 0.99 0.41 0.90 1.03 1.28 2.05 1.76 1.36 1.59 1.44 0.99 1.17 1.92 1.25 1.62


MSMEG_6786 MSMEG_6787 MSMEG_6788 MSMEG_6789 MSMEG_6790 MSMEG_6791 MSMEG_6792 MSMEG_6793 MSMEG_6794 MSMEG_6795 MSMEG_6796 MSMEG_6797 MSMEG_6798 MSMEG_6799




conserved hypothetical protein ribose 5-phosphate isomerase dihydroxyacetone kinase transcriptional regulator, GntR family protein AP endonuclease, family protein 2 3-hydroxybutyryl-CoA dehydrogenase inner membrane permease YgbN hypothetical protein DNA-binding protein enoyl-CoA hydratase/isomerase family protein hypothetical protein carboxymuconolactone decarboxylase rbsR ribose operon repressor aldo/keto reductase; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00248 phosphoribulokinase/uridine kinase kinase, pfkB family protein ABC transporter ATP-binding protein ribose transport system permease protein RbsC sugar ABC transporter substrate-binding protein beta-lactamase uvrA excinuclease ABC, A subunit transcriptional regulator, TetR family protein hypothetical protein cbbQ CbbQ protein nitric oxide reductase activase protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00092 conserved hypothetical protein major facilitator superfamily; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00083 amidohydrolase 2 helix-turn-helix, Fis-type

1.37 1.30 1.14 0.81 2.34 2.68 2.03 1.09 2.00 1.24 0.76 1.68 0.94

2.16E-01 7.92E-02 1.66E-01 4.06E-02 1.67E-02 5.49E-02 1.10E-01 3.54E-01 2.87E-02 3.94E-01 3.83E-01 6.86E-04 5.01E-01

1.12 1.15 1.41 1.12 1.17 1.14 0.88 1.25 1.50 1.04 0.96 0.75 1.80

3.58E-02 1.88E-01 3.40E-02 3.71E-01 3.00E-01 3.08E-01 2.47E-01 1.63E-01 2.40E-01 8.87E-01 6.16E-01 1.74E-02 1.44E-01

0.96 1.18 1.76 0.92 0.22 0.12 1.88 0.80 1.03 1.12 1.08 0.70 0.89

3.92E-01 4.02E-01 1.54E-01 3.36E-01 2.83E-03 4.79E-05 5.92E-01 4.25E-01 4.11E-01 5.28E-01 1.23E-01 7.11E-03 8.95E-02

1.24 1.22 1.32 1.33 1.47 1.95 1.33 1.17 1.49 1.52 1.13

2.47E-01 3.31E-02 2.47E-02 9.77E-02 5.53E-02 1.22E-02 1.56E-01 2.55E-01 8.32E-02 3.57E-01 2.04E-01

1.18 1.56 1.52 1.22 1.02 1.17 0.81 2.12 1.25 1.14 1.00

7.37E-02 1.99E-01 2.02E-01 3.85E-01 8.90E-01 3.20E-01 2.51E-02 1.21E-01 2.99E-01 5.44E-01 9.77E-01

0.93 0.78 0.77 0.55 0.30 0.29 1.25 1.06 0.90 0.96 1.04

6.57E-01 3.44E-02 1.40E-01 4.05E-03 2.28E-04 9.08E-05 9.28E-02 6.53E-01 6.72E-01 5.99E-02 7.92E-01

0.96 2.91

8.45E-01 2.18E-03

1.05 2.09

5.43E-01 1.64E-01

1.06 0.93

3.12E-01 6.90E-01

0.97 1.02 1.03

8.75E-01 8.81E-01 4.10E-01

8.55 4.31 1.06

1.32E-01 1.10E-01 5.60E-01

1.02 0.96 1.30

6.12E-01 5.16E-01 1.86E-01

MSMEG_6815 secreted protein MSMEG_6816 molybdopterin oxidoreductase MSMEG_6817 RNA polymerase sigma factor, sigma-70 family protein MSMEG_6818 dehydrogenase MSMEG_6819 conserved domain protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_6819 conserved domain protein; this gene contains a frame shift which is not the result of sequencing error MSMEG_6820 acid phosphatase SurE MSMEG_6821 NLP/P60 family protein MSMEG_6822 beta-lactamase MSMEG_6823 short-chain dehydrogenase/reductase SDR MSMEG_6824 MarR-family protein regulatory protein MSMEG_6825 caax amino protease family protein, putative MSMEG_6826 L-lactate permease MSMEG_6827 hypothetical protein MSMEG_6828 transcriptional regulator MSMEG_6829 transcriptional regulatory protein MSMEG_6830 conserved hypothetical protein MSMEG_6831 hydrolase, alpha/beta hydrolase fold family protein MSMEG_6832 conserved hypothetical protein MSMEG_6833 alcohol dehydrogenase MSMEG_6834 alcohol dehydrogenase MSMEG_6835 Fatty acid desaturase MSMEG_6836 putative oxidoreductase MSMEG_6837 haloalkane dehalogenase MSMEG_6838 putative esterase MSMEG_6839 transcriptional regulator, AraC family protein MSMEG_6840 LysR-family protein transcriptional regulator MSMEG_6841 hypothetical protein MSMEG_6842 2,2-dialkylglycine decarboxylase MSMEG_6843 NAD-dependent epimerase/dehydratase MSMEG_6844 trap-t family protein transporter, dctp MSMEG_6845 trap dicarboxylate transporter, dctm subunit

surE

1.20 0.34

3.75E-01 1.77E-02

1.11 5.65

4.72E-01 2.58E-01

1.28 0.65

4.54E-01 2.95E-01

2.15 1.52

7.51E-04 1.15E-02

3.70 3.55

1.05E-01 1.21E-01

0.65 0.66

1.35E-01 1.36E-01

0.84

4.31E-02

0.88

7.18E-02

1.15

1.90E-01

1.18 1.22 0.66 0.84 1.42 0.82 1.61 7.97 1.10 1.07 1.41 0.91

1.86E-01 3.66E-01 8.96E-04 2.31E-01 5.56E-03 8.25E-02 1.52E-01 1.82E-03 4.15E-01 7.71E-01 2.84E-03 2.03E-01

1.52 1.11 5.65 1.41 4.66 0.95 0.79 0.79 1.12 0.93 0.80 0.96

1.37E-01 2.80E-01 9.16E-02 8.97E-02 8.17E-02 6.03E-01 1.15E-01 1.05E-01 5.88E-01 6.22E-01 8.57E-03 4.94E-01

1.00 1.45 17.26 1.56 0.49 1.03 1.01 0.18 1.11 1.08 0.90 1.21

9.17E-01 2.77E-01 3.61E-01 4.34E-02 9.91E-04 8.02E-01 3.75E-01 6.96E-04 2.74E-01 2.96E-01 2.15E-01 3.90E-01

5.43 1.45 1.59 2.33 1.16 1.21 2.08 1.81 1.47 0.98 1.24 1.17 2.24 1.12 1.91


0.90 1.05 1.91 1.44 1.00 1.06 0.79 1.64 1.40 0.98 1.22 1.11 0.73 1.53 1.25


1.20 0.85 1.21 1.92 1.11 2.84 1.07 0.95 1.05 1.18 1.17 0.88 0.68 1.02 0.96


MSMEG_6846 MSMEG_6847 MSMEG_6848 MSMEG_6849 MSMEG_6850 MSMEG_6851 MSMEG_6852 MSMEG_6853 MSMEG_6854 MSMEG_6855 MSMEG_6856 MSMEG_6857 MSMEG_6858 MSMEG_6859 MSMEG_6860 MSMEG_6861 MSMEG_6862 MSMEG_6863 MSMEG_6864 MSMEG_6865 MSMEG_6866 MSMEG_6867 MSMEG_6868

MSMEG_6868


putative C4 decarboxylate transport protein conserved hypothetical protein putative oxidoreductase LysR-family protein transcriptional regulator alpha/beta hydrolase phosphatidylethanolamine-binding protein putative carboxylesterase/lipase 3-isopropylmalate dehydratase small subunit 3-isopropylmalate dehydratase large subunit carboxyvinyl-carboxyphosphonate phosphorylmutase MmgE/PrpD family protein putative transcription regulator epoxide hydrolase 1 oxidoreductase conserved hypothetical protein cupin domain protein putative transcription regulator class II aldolase/adducin domain protein putative transcription regulator ABC transporter solute binding lipoprotein dipeptide transport system permease protein DppB oligopeptide ABC transporter integral membrane protein oligopeptide ABC transporter ATP-binding protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00005 oligopeptide ABC transporter ATP-binding protein; this gene contains a frame shift which is not the result of sequencing error; identified by match to protein family HMM PF00005 regulatory protein creatinine amidohydrolase isomerase beta-lactamase

0.78 2.96 3.55 1.38 1.87 1.25 1.52 1.08 1.23

3.87E-03 4.19E-02 6.78E-04 1.65E-01 3.25E-02 3.93E-01 1.74E-02 4.28E-01 1.93E-01

1.05 1.13 0.91 0.94 0.81 1.08 0.99 11.98 2.86

7.06E-01 5.15E-01 4.89E-01 2.76E-01 1.19E-01 2.54E-01 8.02E-01 3.70E-01 2.84E-01

1.13 1.71 1.12 1.53 0.74 1.03 1.00 1.24 1.12

4.20E-01 1.18E-01 4.90E-01 1.68E-01 1.82E-01 3.86E-01 9.25E-01 3.33E-01 4.63E-01

1.18 1.03 1.35 2.40 3.01 3.88 1.23 1.26 1.42 1.07 1.71

4.99E-01 6.19E-01 1.13E-01 1.74E-01 3.74E-03 1.18E-03 9.79E-02 1.50E-02 3.19E-03 5.94E-01 5.04E-03

1.56 2.02 1.12 1.62 1.59 0.71 1.26 0.96 0.97 0.91 0.85

2.61E-01 2.32E-01 4.97E-01 3.53E-01 2.26E-01 9.57E-04 2.74E-01 6.33E-01 6.62E-01 1.21E-01 8.46E-02

0.92 0.96 1.55 1.15 1.06 1.55 0.97 0.93 0.83 0.92 1.06

5.14E-01 6.07E-01 2.54E-01 4.56E-01 2.46E-01 3.69E-01 7.17E-01 5.44E-01 1.83E-01 4.95E-01 4.65E-01

1.52

1.28E-03

0.82

9.35E-02

1.02

8.59E-01

1.53

7.25E-02

0.82

1.59E-03

1.00

9.63E-01

2.20

2.21E-02

0.74

2.07E-02

1.24

1.93E-01

1.27 1.64 1.29 1.12 1.06

1.24E-01 4.56E-02 4.83E-02 2.48E-01 6.03E-01

0.88 0.87 0.86 1.06 0.98

4.02E-02 1.67E-01 6.34E-02 3.27E-01 7.17E-01

0.99 1.11 0.98 1.15 1.02

9.29E-01 3.25E-01 7.93E-01 5.00E-01 5.60E-01

MSMEG_6873 enoyl-CoA hydratase/isomerase; this gene contains a frame shift which is not the result of sequencing error MSMEG_6873 enoyl-CoA hydratase/isomerase; this gene contains a frame shift which is not the result of sequencing error MSMEG_6874 aldehyde dehydrogenase MSMEG_6875 endoribonuclease L-PSP family protein MSMEG_6876 branched chain amino acid transport ATP-binding protein MSMEG_6877 branched-chain amino acid transport system ATPbinding protein MSMEG_6878 inner-membrane translocator MSMEG_6879 integral membrane protein of the ABC-type Nat permease for neutral amino acids NatD MSMEG_6880 hydrophobic amino acid ABC transporter, putative MSMEG_6881 transcriptional regulator, GntR family protein MSMEG_6882 LysR-family protein transcriptional regulator MSMEG_6883 hypothetical protein; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error; identified by Glimmer2; putative MSMEG_6884 NADP oxidoreductase, coenzyme f420dependent:6-phosphogluconate dehydrogenase, nad-binding, putative MSMEG_6885 MmcI protein MSMEG_6886 transcriptional regulator MSMEG_6887 amidohydrolase family protein MSMEG_6888 transposase subunit MSMEG_6889 transposase MSMEG_6890 antibiotic biosynthesis monooxygenase domain protein MSMEG_6891 ribonuclease H; this region contains one or more premature stops and/or frameshifts which are not the result of sequencing error MSMEG_6892 replicative DNA helicase MSMEG_6893 hypothetical protein

0.40

4.91E-07

1.46

9.26E-02

0.93

1.36E-01

0.69 0.30 0.72

2.92E-02 1.41E-04 1.14E-02

1.21 0.94 0.93

2.48E-01 5.81E-01 4.83E-01

1.17 1.06 1.02

4.01E-01 5.41E-01 7.24E-01

0.65

5.12E-02

1.01

8.69E-01

0.78

1.53E-01

0.54 0.24

4.35E-02 3.11E-05

1.14 1.17

1.86E-01 5.93E-01

1.22 1.02

3.96E-01 7.72E-01

0.34

3.14E-04

0.98

8.00E-01

0.90

2.19E-01

0.15 0.47 1.69

1.96E-05 4.03E-03 8.09E-02

1.13 1.04 0.82

3.62E-01 8.13E-01 1.76E-01

0.79 0.75 1.34

1.39E-01 1.35E-01 1.51E-01

1.53

1.79E-03

1.06

5.90E-01

1.21

3.12E-01

1.70 1.37 1.66 1.10 0.70 1.95

8.44E-02 4.49E-03 9.30E-03 3.15E-01 1.05E-03 3.38E-01

1.11 0.91 0.89 1.34 0.80 1.05

4.39E-01 2.31E-01 8.60E-02 1.23E-01 4.23E-02 6.06E-01

0.89 0.45 1.04 1.08 0.98 0.88

3.97E-01 4.03E-04 7.45E-01 4.01E-01 5.22E-01 1.71E-01

1.39

6.96E-02

1.14

3.76E-01

2.03

2.09E-01

1.17 0.71 0.95

3.26E-01 2.39E-03 8.58E-01

0.99 1.02 1.11

9.10E-01 8.34E-01 3.52E-01

1.10 1.67 1.18

5.55E-01 2.35E-02 5.37E-01

MSMEG_6894 MSMEG_6895 MSMEG_6896 MSMEG_6897 MSMEG_6898 MSMEG_6899 MSMEG_6900 MSMEG_6901 MSMEG_6902 MSMEG_6903 MSMEG_6904 MSMEG_6906 MSMEG_6907 MSMEG_6908 MSMEG_6909

rplI ribosomal protein L9 rpsR ribosomal protein S18 single-stranded DNA-binding protein rpsF ribosomal protein S6 hypothetical protein conserved hypothetical protein penicillin-binding protein 1 conserved hypothetical protein putative membrane protein transcriptional regulator, PadR family protein myo-inositol-1-phosphate synthase putative hydrolase MmcI protein putative HTH-type transcriptional regulator amino acid ABC transporter, permease protein, 3TM region, His/Glu/Gln/Arg/opine family protein


ABC transporter, ATP-binding protein GluA putative transcriptional regulatory protein conserved hypothetical protein short chain dehydrogenase leucyl-tRNA synthetase proline-rich 28 kDa antigen hypothetical protein conserved hypothetical protein transporter, major facilitator family protein conserved hypothetical protein conserved hypothetical protein tRNA adenylyltransferase MutT/nudix family protein conserved hypothetical protein integral membrane protein MviN, putative hypothetical protein RNA polymerase sigma-70 factor conserved hypothetical protein thioredoxin-disulfide reductase thioredoxin N-acetylmuramoyl-L-alanine amidase

leuS

trxB trx

0.27 0.44 0.54 0.40 1.04 0.50 0.52 1.28 0.60 1.30 0.90 0.71 1.85 1.16

5.53E-07 1.17E-05 4.46E-04 2.65E-04 8.38E-01 2.65E-03 1.38E-04 1.00E-02 7.75E-02 6.59E-03 1.03E-01 2.20E-03 6.64E-02 1.41E-01

0.79 0.82 0.91 0.89 1.00 1.02 0.88 0.87 1.20 1.03 0.84 0.80 0.82 0.95

1.08E-01 3.39E-02 2.38E-01 3.41E-01 9.84E-01 5.92E-01 1.90E-01 1.36E-01 1.50E-01 8.89E-01 4.53E-01 1.45E-02 1.68E-01 2.60E-01

0.88 0.39 0.86 0.80 1.57 1.37 2.21 1.31 0.86 0.54 0.73 0.89 0.71 0.97

2.93E-01 1.61E-05 4.42E-02 4.93E-02 1.50E-01 1.46E-01 1.38E-02 2.40E-01 1.62E-01 6.08E-03 1.72E-02 2.18E-01 2.17E-03 5.80E-01

1.15 1.13 1.50 1.27 0.61 0.43 1.78 0.92 2.13 0.84 0.90 1.17 0.27 0.69 0.68 0.56 1.26 1.07 0.73 1.06 2.39 1.10


1.01 0.96 0.88 1.00 0.87 1.09 0.70 0.72 0.80 0.86 0.88 1.16 0.99 0.80 0.90 1.29 1.05 1.40 0.93 1.30 0.80 0.87


0.90 2.46 0.51 1.36 2.58 2.57 0.97 1.25 0.96 3.41 1.53 1.06 1.83 1.77 1.49 1.09 1.31 0.81 1.17 1.50 0.90 1.10



conserved hypothetical protein ParB-like partition proteins Soj family protein methyltransferase GidB R3H domain-containing protein membrane protein OxaA conserved hypothetical protein, putative ribonuclease P protein component ribosomal protein L34 chromosomal replication initiator protein DnaA

gidB

rnpA rpmH dnaA

1.71 1.25 0.74 1.10 0.69 0.59 0.57 1.32 1.08 0.98

3.06E-05 5.81E-03 2.47E-02 1.96E-01 1.49E-03 1.92E-04 2.00E-04 7.67E-03 1.84E-01 6.98E-01

0.68 0.84 1.12 1.06 0.93 0.85 0.86 0.91 0.89 0.90

2.77E-02 1.57E-02 1.68E-01 4.65E-01 4.26E-01 4.94E-02 2.17E-02 3.13E-01 1.52E-01 2.71E-01

1.47 1.05 1.39 1.62 1.29 1.02 0.81 0.79 0.69 0.52

1.61E-01 5.82E-01 1.11E-02 5.55E-02 2.04E-02 9.16E-01 9.62E-02 1.05E-01 1.22E-01 3.02E-05