Feb 24, 2018 - measurements, plasma levels of osteoprotegerin (OPG), matrix metallopeptidase-9. (MMP-9), fetuin A, adiponectin, interleukins 6 and 1β (IL-6, ...
Nephrology Dialysis Transplantation 31 (Supplement 1): i68–i69, 2016 doi:10.1093/ndt/gfw146.1
DIABETES CLINICAL TO016
COMPARISON OF DIFFERENT MARKERS OF VASCULAR DAMAGE IN TYPE 1 DIABETIC PATIENTS WITH END-STAGE RENAL DISEASE AFTER KIDNEY OR SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION
Jerzy Chudek1, Joanna Badura2, Jacek Ziaja2, Aureliusz Kolonko3, Dorota Kamin´ska4, Aleksander Owczarek5, Adrian Kowalik2, Agata Kujawa-Szewieczek6, Mariusz Kusztal7, Joanna Kluz8, Marian Klinger7, Andrzej Wiecek9 and Lech Cierpka2 1 Medical University of Silesia, Pathophysiology, Katowice, POLAND, 2Medical University of Silesia, General, Vascular and Transplant Surgery, Katowice, POLAND, 3Medical University of Silesia, Dept of Nephrology, Endocrinology and Metabolic Diseases, Katowice, POLAND, 4Wrocław Medical University, Dept of Nephrology and Transplantation Medicine, Wrocław, POLAND, 5Medical University of Silesia, Division of Statistics, Department of Instrumental Analysis, Sosnowiec, POLAND, 6Medical University of Silesia, Dept of Nephrology and Transplantation Medicine, Katowice, POLAND, 7Medical University of Silesia, Dept of Nephrology and Transplantation Medicine, Wrocław, POLAND, 8Wrocław Medical University, Dept. of Angiology, Arterial Hypertension and Diabetology, Wrocław, POLAND, 9 Medical University of Silesia, Dept. Nephrology, Transplantology and Internal Medicine, Katowice, POLAND Introduction and Aims: Simultaneous pancreas-kidney transplantation (SPK) is considered as the optimal treatment for type 1 diabetic patients with end-stage renal disease (ESRD). In comparison to kidney transplantation alone (KTA), the
improvement of blood glucose control after SPK is anticipated to slow the progression of vascular damage, which occurred in the pre-transplant period. The aim of the study was to compare the severity of vascular damage, based on intima-media thickness (IMT) and pulse wave velocity (PWV) measurements and on biochemical markers, in type 1 diabetic patients with ESRD in the follow-up after SPK or KTA. Methods: 39 SPK, 39 diabetic KTA and 52 non-diabetic kidney-transplanted patients (KTx), matched for gender, pre-transplant dialysis vintage (mean 26±21 months), were enrolled into this two-centre study. In all participants, in addition to IMT and PWV measurements, plasma levels of osteoprotegerin (OPG), matrix metallopeptidase-9 (MMP-9), fetuin A, adiponectin, interleukins 6 and 1β (IL-6, IL-1β), tumour necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hs-CRP) were measured. Results: During 50-month mean follow-up period, SPK resulted in long-term normalization of HbA1C (5.5±1.0 vs. 7.9±1.4 in KTA vs. 5.4±0.5% in KTx). As KTA group was 6 years older than SPK, all analyses were performed with the correction for age (applying ANCOVA). Both diabetic groups were characterized by significantly increased IMT (0.66±0.02 in SPK and 0.72±0.02 in KTA vs. 0.56±0.01 mm in KTx group), with a higher values observed in KTA patients ( p
