Dietary Curcuma longa protects myocardium against isoproterenol induced hemodynamic, biochemical and histopathological alternations in rats. Mohanty IR*. +.
International Journal of Applied Research in Natural Products Vol. 1(4), pp. 19-28, Dec 2008-Jan 2009 Available online http://www.healthy-synergies.com ©2008 Healthy Synergies Publications
Original Article
Dietary Curcuma longa protects myocardium against isoproterenol induced hemodynamic, biochemical and histopathological alternations in rats Mohanty IR*+, Arya DS, Gupta SK Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India Summary: The present study was designed to investigate whether Curcuma longa (Cl), a natural herb, would attenuate the acute myocardial infarction in isoproterenol (ISP)-treated rat model via maintaining cardiac function and activities of endogenous antioxidant enzymes. Haemodynamic parameters {systolic, diastolic and mean arterial pressure (SAP, DAP, MAP), heart rate (HR), left ventricular end-diastolic pressure (LVEDP), left ventricular (LV) peak positive (+) dP/dt (rate of pressure development) and negative (-) dP/dt (rate of pressure decline)}were recorded. Cardiac marker enzyme: Creatinine phosphokinase(CPK) and antioxidative parameters: Glutathione (GSH), Thiobarbituric acid reactive substances (TBARS), Catalase (CAT), Glutathione peroxidase (GSHPx and Superoxide dismutase (SOD) of heart tissues were measured. Histopathological examination of heart tissues was also performed. Induction of rats with ISP (85 mg/kg) on 29th and 30th day, s.c. resulted in significant cardiac necrosis, decline in cardiac function, antioxidant status and elevation in lipid peroxidation. Oral administration of Cl (50, 100 and 200 mg/kg, respectively) to healthy experimental animals (i.e. animals without any myocardial pathologic challenge viz. ISP) for 30 days significantly enhanced the basal myocardial levels of GSHPx (p
