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RESEARCH ARTICLE

Diffusion spectrum imaging in white matter microstructure in subjects with type 2 diabetes Qing Zhang, Yawen Xiao, Lin Lin, Jianlin Wu ID* Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China * [email protected]

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OPEN ACCESS Citation: Zhang Q, Xiao Y, Lin L, Wu J (2018) Diffusion spectrum imaging in white matter microstructure in subjects with type 2 diabetes. PLoS ONE 13(11): e0203271. https://doi.org/ 10.1371/journal.pone.0203271 Editor: Huiguang He, Chinese Academy of Sciences, CHINA Received: December 21, 2017 Accepted: August 18, 2018 Published: November 14, 2018 Copyright: © 2018 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The study was supported by the National Natural Science Foundation of China (no. 81371526). Competing interests: The authors have declared that no competing interests exist.

This study aimed to investigate the feasibility and clinical applicability of Diffusion Spectrum Imaging (DSI) for quantitative detection of white matter microstructural integrity. Twentyseven patients with type 2 diabetes mellitus (T2DM; aged 60.6±7.6 years) and 21 healthy controls (HC; aged 56.1±7.8 years) underwent high-resolution T1-weighted imaging and DSI scanning. Cognitive function scores were obtained using such instruments as the Montreal Cognitive Assessment (MoCA). The fasting blood glucose, glycated hemoglobin, and total cholesterol (CHO) of T2DM were measured. The bilateral uncinate fasciculus and superior cingulum bundle were reconstructed by DSI tractography. Statistical analysis was performed using SPSS 21.0 software and P