Disclosures References

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Study Of Bladder Carcinoma Grade At First Presentation In Tertiary Hospital. Nadeem M1, Khan JH1, Ahmed N1. 1. Mayo Hospital, Lahore, Pakistan. Methods.
Study Of Bladder Carcinoma Grade At First Presentation In Tertiary Hospital Nadeem M1, Khan JH1, Ahmed N1. 1. Mayo Hospital, Lahore, Pakistan

Background Bladder cancer is one of the most common diseases treated by the urologists. Bladder cancer is the second most common cancer of the genitourinary tract and the second most common cause of death among genitourinary tumors after prostate cancer. Incidence of carcinoma of urinary bladder in Pakistan is 0.7%. It is the fourth most common cancer after prostate, lungs and colorectal cancer accounting for 5.5% of all cancer cases. Male to female ratio of the urinary bladder carcinoma in Pakistan is 3.2:1. This incidence in Pakistan was somewhat similar to that of USA which is 3.3:1 and also similar to Britain which is 2.8:1.

Table 1. Gender, Growth and Grade of bladder tumors Male

Female

53 (88.3%)

7 (11.7%)

Right

Left

23 (38.3%)

26 (43.3%)

There is no uniformly accepted grading system for bladder cancer. The well differentiated tumours are also known as grade I tumours. The moderately differentiated carcinoma may be called as grade II tumours. The poorly differentiated tumours are also named as grade III tumours. In our study the mean age of the patients was 57.1±12.4 years. Which is comparable with the study of Al-Bazzaz who quoted mean age of the patients was 57.9 years. In our study there were 88.3% male and 11.7% female patients. As compared with the study of Al-Bazzaz there were 75% male and 25% female patients, which is comparable with our study. In our study in the bladder growth grading, 18.3% patients had grade I, 68.3% patients had grade II and 13.3% patients had grade III bladder growth. As compared with the study of Schned et al 52.5% patients had grade I, 21.4% had grade II and 26.1% patients had grade III, which is comparable with our study It is concluded from this study that patients with bladder cancer are diagnosed at a relatively early stage and grade. However, the situation can be improved further by adopting proper screening programs and initiating early management

Gender

Aims The grade of urinary bladder cancer is an important factor in determining the prognosis of the disease. .

Methods In this cross sectional study, sixty patients of urinary bladder carcinoma were selected from outdoor department of Urology, Unit II, Mayo Hospital Lahore. The detail procedure was explained to the patients and informed consent was obtained from the patients. All relevant information was recorded in the proforma, the relevant investigations were carried out. Data was collected on predesigned proforma. Detailed history, physical examination and relevant investigations were carried out to stage and grade the disease. All bladder cancer cases were recorded and evaluated. Available investigations and operation notes were studied to evaluate the diagnosed cases for stage and grade of bladder cancer over a period of one year.

Growth

References Large and small

multiple papillary

6 (10.0%)

5 (8.3%)

Grade I

Grade II

Grade III

• Marks, Soloway, Sofer M, Vaidyax. Contemporary management of stage T1 transitional cell carcinoma of the bladder. J Urol 2002; 167:1573-83. • Kazi IJ, Mubarak M, Hashmi A, Hussain M, Naqvi AS, Rizvi HAS. Spectrum of pathological lesions in cystoscopic bladder biopsies - a clinicopathologic study. J Coll Physicians Surg Pakistan 2002; 12:744-7. • Siyal AR, Shaikh SM, Jalbani MH, Jalbani MH, Rathi SL, Chand H. A clinicopathological study of 108 cases of urinary bladder cancer at Chandka Medical College & Hospital, Larkana. J Surg Pak (International) 1999; 4:7-9. • Stein JP, Ginsberg DA, Groosfeld GD, Chatterjee SG, Esring D, Dickinson Mg et al. Effect of P21 waf 1/ Cipl: Expression on tumour, Progression in bladder cancer. J Natl Cancer Inst 1998; 90:1072-79. • Chinegwundoh FI, Kaisary AV. Polymorphism and smoking in bladder carcinogenesis. Br J Urol 1996; 77:672. • Schned RA, Andrew SA, Marsit JC, Kelsey TK, Zens SM, Karagas RM. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scand J Urol Nephrol 2008; 42: 237-42. • Al-Bazzaz PH. Stage of urinary bladder cancer at first presentation. Saudi J Kidney Dis Transplant 2009; 20: 628-31.

11 (18.3%)

41 (68.3%)

8 (13.3%)

Disclosures

Results The mean age of the patients was 57.1±12.4 years. There were 53 (88.3%) male and 7 (11.7%) female patients. In the distribution of patients by cystoscopy finding, there were 26 (43.3%) patients who had bladder growth on left side, 23 (38.3%) patients had bladder growths on right side, 6 (10.0%) patients had bladder growth large and small, 5 (8.3%) patients had multiple papillary growths. In the bladder growth grading, 11 (18.3%) patients had grade I, 41 (68.3%) patients had grade II and 8 (13.3%) patients had grade III bladder growth (Table 1)

Discussion & Conclusion

Grade

There is a nothing to disclose.