PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA (CAH) . 2. O.A.Müller\ R.Fink , P.C.Scriba , J.Weil ,F^ Bidlingmaier and D.ffnorr . Medizinische Klinik ...
endocrino logica Supplementum 225
Advance Abstracts of Papers
XII
Acta Endocrinologica Congress Munich June 26-30,1979
PERIODICA • C O P E N H A G E N 1979
Eigentum der M ü n c h e n
GENERAL CONTENTS IV VI
C o n t e n t s in detail Time-Table Poster S e s s i o n s Short C o m m u n i c a t i o n S e s s i o n s - O r a l P r e s e n t a t i o n Symposia Plenary L e c t u r e s Anwards A u t h o r s ' Index
1-353 354-413 414-487 488-493 494-513 515-527
P R O G R A M M E ORGANIZING C O M M I T T E E Chairman:
J . Zander (München)
Secretary:
P. C. S c r i b a ( M ü n c h e n ) F. B i d l i n g m a i e r (München) M. B r e c k w o l d t (Freiburg) O. B u t e n a n d t (München) R. C l a u s ( M ü n c h e n - W e i h e n s t e p h a n ) J . H a m m e r s t e i n (Berlin) K. D. H e p p (München) P. W. J u n g b l u t (Wilhelmshaven) H. Karg ( M ü n c h e n - W e i h e n s t e p h a n ) D. K n o r r ( M ü n c h e n ) R. Landgraf ( M ü n c h e n ) H. M e h n e r t ( M ü n c h e n ) H. M i c k a n ( M ü n c h e n ) E. F. Pfeiffer (Ulm) C. Renate P i c k a r d t ( M ü n c h e n ) D. S c h a m s ( M ü n c h e n - W e i h e n s t e p h a n ) R o s m a r i e V o g e l (München) K. von Werder (München) W.Wuttke (Göttingen) R. Z i e g l e r (Ulm)
III
CONTENTS Abstract numbers
POSTER SESSIONS I, II, III
a n d
Thyroid TSHandTSI Adrenal A C T H and Related Peptides Testis Ovary Pregnancy Puberty G o n a d o t r o p h i ns Prolactin Growth H o r m o n e Pituitary Tumor Oxytocin/ADH Hypothalamus Pineal/Brain Hormones Hormonal Effects on C N S / B e h a v i o u r Comparative E n d o c r i n o l o g y / P h e r o m o n e s Receptors - S e x u a l Steroids Receptors - C o r t i c o s t e r o i d s Receptors - P r o t e o h o r m o n e s Metabolism / Obesity Gastrointestinal H o r m o n e s Parathyrin/Vitamin D/Calcitonin Hypertension
p a g e s
1 - 26 2 7 - 47 4 8 - 56 5 7 - 81 8 2 - 96 97-114 115-120 121-128 129 - 1 5 7 158-187 188-200 201 - 2 0 5 206-218 219-236 237-244 245-253 254-260 261 - 2 8 0 281 - 2 8 6 287-301 302-321 322-325 326-335 336-353
SHORT COMMUNICATION SESSIONS 1-6 - ORAL PRESENTATION SC SC SC SC SC SC
1a 1b 2a 2b 3a 3b
Gonadotrophins Ovary/Placenta Thyroid Hypothalamic H o r m o n e s A C T H and Related Peptides Hypertension
354-358 359-363 364-369 370-373 374-379 380-383
SC SC SC SC SC SC
4a 4b 5a 5b 6a 6b
S t e r o i d s : M e t a b o l i s m , Effect Hypogonadism Prolactin/Growth Hormone Parathyrin Metabolism/Gastrointestinal Hormones Antidiuretic H o r m o n e
384-389 390-393 394-399 400-403 404-408 409-413
IV
SYMPOSIA 1-9
Abstract / numbers
S 1 S2 S3
Neuropeptides Pheromones The Insulin R e c e p t o r
4 1 4 -- 4 1 8 / 4 1 4 - -422 4 1 9 --424 / 4 2 3 --433 4 2 5 --429 / 434--441
S4 S5
P r o g r e s s in T h y r o i d o l o g y " K i d n e y H o r m o n e s " in the R e g u l a t i o n of V a s c u l a r a n d Tubular F u n c t i o n s Sexual Dimorphism
4 3 0 - -434 / 442--449
R e g u l a t i o n of G o n a d o t r o p h i n S e c r e t i o n Hormone Receptor Systems P r o g r e s s in the M a n a g e m e n t of Disorders of C a l c i u m M e t a b o l i s m a n d B o n e Diseases
445-- 4 4 9 / 466--472 450-- 4 5 4 / 473--480
S6 S7 S8 S9
pages
4 3 5 -- 4 3 9 / 450--456 440-- 4 4 4 / 457--465
455-- 4 5 9 / 4 8 1 - - 4 8 7
PLENARY LECTURES B.T. P I C K E R I N G : C e l l u l a r m e c h a n i s m of h o r m o n e synthesis, transport a n d release H. S T U D E R : P a t h o g e n e t i c m e c h a n i s m s resulting in euthyroid a n d hyperthyroid, n o n - i m m u n o g e n i c goiters W. J . IRVINE: I m m u n o l o g y of d i a b e t e s mellitus a n d other e n d o c r i n e d i s e a s e s
FOURTH G E O F F R E Y HARRIS M E M O R I A L L E C T U R E : B. F L E R K O : T h e h y p o p h y s i a l portal circulation to-day AWARDS OF THE G E R M A N SOCIETY FOR E N D O C R I N O L O G Y
V
460 /
488
461 /
489
462 /
491
463 /
492
464-468 / 494-513
S u p p l . 225 (1979)
A c t a e n d o c r . (Kbh.)
49
DIURNAL PLASMA-ACTH-LEVELS IN CORTICOSTEROID TREATED PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA (CAH) . O . A . M ü l l e r \ R.Fink , P . C . S c r i b a , J . W e i l ,F^ B i d l i n g m a i e r and D.ffnorr . M e d i z i n i s c h e K l i n i k I n n e n s t a d t and K i n d e r K l i n i k , U n i v e r s i t a e t Muenchen, FRG.
2
The t h e r a p e u t i c a l c o n t r o l of C A H - p a t i e n t s by measuring a s i n g l e parameter of the s t e r o i d hormones i s c o n t r o v e r s i a l . The measurement of d i f f e r e n t a d r e n a l androgens has not g i v e n the a w a i t e d u s e f u l r e s u l t s ( 1 ) . The same has been seen f o r s i n g l e plasma-ACTH-levels ( 2 ) . T h i s study has measurgd thg plasma-ACTHl e v e l s a t d i f f e r e n t times d u r i n g the day (08 ,12 ,18 ,24 ) t o a s s e s s the t h e r a p e u t i c a l v a l u e o f 2 d i f f e r e n t c o r t i c o s t e r o i d s , c o r ^ j s o l ^F) a n d p r e d n i s o n e ( P ) , u s u a l l y g i v e n 3 times d a i l y (08 ,13 ,21 ). In a d d i t i o n , i n the p a t i e n t s w i t h s a l t l o s s , 9 a - F - c o r t i s o l was g i v e n . The d i u r n a l v a r i a t i o n of plasma-ACTH and 17ct-0H-progesterone (17-OHP) and F was examined i n 20 pat i e n t s , 9 o f which were re-examined a f t e r a l t e r a t i o n o f t h e r a p y . Plasma-ACTH was measured by radioimmunoassay (RIA) a f t e r e x t r a c t i o n ( 3 ) . Plasma s t e r o i d s were measured by RIA a f t e r p r i o r chromatography on Sephadex LH-20 columns ( 4 ) . RESULTS : A C T H - l e v e l s were on the whole g l e v a t e d , w i t h maximal v a l u e s a t 0 8 ° ° , f a l l i n g t o a minimum a t 24 °. There was a s i g n i f i c a n t c o r r e l a t i o n between A C T H - l e v e l s and 17-OHP (n=114) a f t e r a l o g a r i t h m i c t r a n s f o r m a t i o n (r=0.639, p
