Sumarno Reto Prawiros. 2 ... de Beek et al., 2006) until now although the new
antibacterial drugs was applied ... and causing BBBP disruption (Boje et al., 2003
).
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 – 6718, ISSN (Print): 2319 – 670X www.ijpsi.org Volume 2 Issue 3 ‖ March 2013 ‖ PP.01-05
Adrenocorticotrophin Hormone4-10 synthetic inhibit ProstaglandinE2 and IL-1β levels in LPS-induce meningitis Erny1, Sumarno Reto Prawiros2, HMS Chandra K3, M Istiadjid ES4, Darto Saharso5 1
Post Graduate Study Faculty of Medicine Brawijaya University Malang Indonesia/ Department of Pediatric, Faculty of Medicine, Wijaya Kusuma University, Surabaya, Indonesia 2 Laboratory of Microbiology Medical Faculty of Brawijaya University Malang Indonesia 3 Department of Pediatric, Faculty of Medicine, Brawijaya University, Malang, Indonesia 4 Department of Neurosurgery, Faculty of Medicine, Brawijaya University, Malang, Indonesia 5 Department of Pediatric, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
ABSTRACT: Bacterial meningitis is still a health problem throughout the world, despite being applied to the newest generation of anti-infective drugs. Intracerebral inflammation is need a lot of attention due to bacterial products released during bacterial lysis could trigger a cascade of inflammatory. Anti-inflammatory drug is a logical reasoning to improve the outcome of disease. ACTH 4-10 synthetic is identified as neuropeptide, identically with aMSH exogen because α-MSH shares the first 13 amino acids sequence with ACTH4-10 and receptor was used to have a series of functions anti-inflammatory effects. Purpose of this study is to determine the effect of administration ACTH4-10 synthetic on levels of PGE2 and IL-1b as proinflammatory mediators in LPS-induced meningitis in animals. Research methods, experimental studies in wistar rats, the control group with LPS intrasisternal and intranasal placebo (n = 18), the experimental group with LPS and ACTH4-10 intranasally (n = 18). The variables are PGE2 and IL-1b levels from CSF were analyzed statistically. The results showed that the levels of IL-1b and PGE2 significantly different between the control group and the experimental group (p
