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Shijia Li1,3,5, Liliana Ramona Demenescu1,3, Bin Zhang1,6, Anna Linda Krause1,4, Coraline Metzger1,4, Martin Walter1-4
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Clinical Affective Neuroimaging Laboratory (CANLAB) Magdeburg, Germany
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1. Bermpohl F, et al. (2006) Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy. Human Brain Mapping 27(8):662-677. 2. Herwig U, et al. (2007) Modulation of anticipatory emotion and perception processing by cognitive control. NeuroImage 37(2):652-662. 3. Menon V & Uddin LQ (2010) Saliency, switching, attention and control: a network model of insula function. Brain Structure and Function 214(5-6):655-667. 4, Eickhoff S, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, Zilles . A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. NeuroImage 25(4), 1325-1335, 2005 (Anatomy toolbox)
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* Fig.2 & 3: Activation clusters are thresholded at p ≤0.05 (FWE. cor.) * MCC: middle cingulate cortex; IPL: inferior parietal lobula; Occipi: occipital gyrus; SPL: superior parietal lobula; V1: primary visual cortex; IFG: inferior frontal gryus; Tha: thalamus; Hip: hippocampus; Parahip: parahippocampal gyrus; FG: fusiform gyrus;
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Contact:
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(Fig. 2C) Viewing expected picture activated stronger inferior frontal and occipital regions than viewing unexpected pictures). (Fig. 2D) Further, expectancy attenuated calcarine-fusiformparahippocampal gyrus response to high vs. low salient pictures than unexpected pictures.
References
1. Expectancy mediate attention through a salience network baseline shift before incoming visual stimuli, and through decrease the fusiform-parahippocapal gyrus activation. 2. The salience network is functional connected with visual areas and plays an important role in top-down control and bottom-up response.
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Figure 3. Psychophysiological interaction (PPI) analysis revealed a functional connectivity between the salience network and calcarinelingual-fusiform areas (Fig. 3) that especially during picture salience detection and expectancy by salience interaction. (Fig. 3A) ACC showed increased coupling with visual areas including calcarine sulcus, lingual gyrus and fusiform gyrus during salience detection. (Fig. 3B) In addition, left AI is functional connected with visual areas in mediating salience by expectancy interaction.
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Figure 1. Salience expectancy task.
Figure 2. Brain activation during different conditions in the task. (Fig. 2A&B) We found strong salience effect in AI and ACC during expectancy cues and pictures display). (Fig. 2B) Salience detection with pictures activated somatosensory areas, occipital areas, ventral prefrontal areas, hippocampus and thalamus.
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56 healthy participants underwent a salience expectancy task (Fig. 1) in a functional magnetic resonance imaging (fMRI) study. 40 International Affective Picture System (IAPS) pictures with high or low salient stimuli were presented in an event-related design. To determine brain areas associated with expectancy of incoming events, half of the pictures were preceded by an expectancy cue and half were without. Psychophysiological analysis (PPI) was conducted to determine neural mechanism of expectancy and salience effect on the functional connectivity of AI, dorsal ACC (dACC), pregenual ACC (pgACC).
Results
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The human recognition of the world has been highly influenced and regulated by attention, which is modulated by both expectancy and stimulus salience. A salience network anchored in anterior insula (AI) and anterior cingulate cortex (ACC) plays a key role in salience detection and attention regulation process (1-3). The study aims to investigate salience and expectancy interaction on neural mechanism especially brain network connectivity of attentional processing.
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Introduction
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1Clinical Affective Neuroimaging Laboratory (CANLAB), Department for Behavioral Neurology, Magdeburg, Germany 2 Leibniz Insitute for Neurobiology, Magdeburg, Germany 3 Department of Neurology, Otto von Guericke University, Magdeburg, Germany 4 Department of Psychiatry and Psychotherapy, Department of Neurology, Otto von Guericke University, Magdeburg, Germany 5 Biological Psychology Lab, Department of Psychology, European Medical School, Carl von Ossietzky University, 26111 Oldenburg, Germany 6 Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China
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Functional connectivity of a salience network involving anterior insula and anterior cingulate cortex during an expectancy task
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